Amino acid dipepetide frequency for Roseivirga pacifica

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.576AlaAla: 5.576 ± 0.089
0.641AlaCys: 0.641 ± 0.023
4.211AlaAsp: 4.211 ± 0.076
4.929AlaGlu: 4.929 ± 0.063
3.818AlaPhe: 3.818 ± 0.052
5.075AlaGly: 5.075 ± 0.085
1.21AlaHis: 1.21 ± 0.03
5.49AlaIle: 5.49 ± 0.064
4.691AlaLys: 4.691 ± 0.063
7.114AlaLeu: 7.114 ± 0.078
1.869AlaMet: 1.869 ± 0.036
3.802AlaAsn: 3.802 ± 0.05
2.367AlaPro: 2.367 ± 0.047
2.991AlaGln: 2.991 ± 0.043
2.412AlaArg: 2.412 ± 0.043
4.545AlaSer: 4.545 ± 0.063
4.099AlaThr: 4.099 ± 0.082
4.538AlaVal: 4.538 ± 0.068
0.765AlaTrp: 0.765 ± 0.027
2.831AlaTyr: 2.831 ± 0.044
0.0AlaXaa: 0.0 ± 0.0
Cys
0.47CysAla: 0.47 ± 0.018
0.081CysCys: 0.081 ± 0.008
0.389CysAsp: 0.389 ± 0.019
0.414CysGlu: 0.414 ± 0.02
0.377CysPhe: 0.377 ± 0.02
0.54CysGly: 0.54 ± 0.023
0.168CysHis: 0.168 ± 0.012
0.467CysIle: 0.467 ± 0.018
0.326CysLys: 0.326 ± 0.015
0.648CysLeu: 0.648 ± 0.024
0.154CysMet: 0.154 ± 0.01
0.316CysAsn: 0.316 ± 0.018
0.305CysPro: 0.305 ± 0.022
0.219CysGln: 0.219 ± 0.014
0.193CysArg: 0.193 ± 0.012
0.5CysSer: 0.5 ± 0.026
0.34CysThr: 0.34 ± 0.017
0.358CysVal: 0.358 ± 0.015
0.072CysTrp: 0.072 ± 0.006
0.255CysTyr: 0.255 ± 0.015
0.0CysXaa: 0.0 ± 0.0
Asp
3.913AspAla: 3.913 ± 0.059
0.34AspCys: 0.34 ± 0.016
3.087AspAsp: 3.087 ± 0.055
4.113AspGlu: 4.113 ± 0.056
3.554AspPhe: 3.554 ± 0.06
4.344AspGly: 4.344 ± 0.105
0.984AspHis: 0.984 ± 0.029
3.873AspIle: 3.873 ± 0.063
3.6AspLys: 3.6 ± 0.061
5.518AspLeu: 5.518 ± 0.076
1.291AspMet: 1.291 ± 0.031
2.826AspAsn: 2.826 ± 0.056
2.106AspPro: 2.106 ± 0.048
2.078AspGln: 2.078 ± 0.044
2.275AspArg: 2.275 ± 0.04
3.126AspSer: 3.126 ± 0.055
2.463AspThr: 2.463 ± 0.042
3.687AspVal: 3.687 ± 0.062
0.86AspTrp: 0.86 ± 0.027
2.65AspTyr: 2.65 ± 0.046
0.0AspXaa: 0.0 ± 0.0
Glu
5.362GluAla: 5.362 ± 0.071
0.298GluCys: 0.298 ± 0.016
3.715GluAsp: 3.715 ± 0.058
5.444GluGlu: 5.444 ± 0.079
3.09GluPhe: 3.09 ± 0.047
4.436GluGly: 4.436 ± 0.053
1.316GluHis: 1.316 ± 0.033
4.766GluIle: 4.766 ± 0.063
5.001GluLys: 5.001 ± 0.072
6.791GluLeu: 6.791 ± 0.076
1.846GluMet: 1.846 ± 0.039
3.797GluAsn: 3.797 ± 0.053
1.991GluPro: 1.991 ± 0.038
2.877GluGln: 2.877 ± 0.046
2.965GluArg: 2.965 ± 0.056
3.728GluSer: 3.728 ± 0.051
3.503GluThr: 3.503 ± 0.052
5.08GluVal: 5.08 ± 0.065
0.766GluTrp: 0.766 ± 0.025
2.402GluTyr: 2.402 ± 0.041
0.0GluXaa: 0.0 ± 0.0
Phe
3.285PheAla: 3.285 ± 0.048
0.37PheCys: 0.37 ± 0.017
3.378PheAsp: 3.378 ± 0.05
3.728PheGlu: 3.728 ± 0.054
2.574PhePhe: 2.574 ± 0.056
3.798PheGly: 3.798 ± 0.058
0.845PheHis: 0.845 ± 0.027
3.251PheIle: 3.251 ± 0.059
3.125PheLys: 3.125 ± 0.052
4.465PheLeu: 4.465 ± 0.072
1.127PheMet: 1.127 ± 0.031
3.002PheAsn: 3.002 ± 0.049
1.674PhePro: 1.674 ± 0.036
1.676PheGln: 1.676 ± 0.036
1.927PheArg: 1.927 ± 0.035
3.8PheSer: 3.8 ± 0.062
3.054PheThr: 3.054 ± 0.052
3.136PheVal: 3.136 ± 0.056
0.571PheTrp: 0.571 ± 0.021
2.059PheTyr: 2.059 ± 0.04
0.0PheXaa: 0.0 ± 0.0
Gly
4.996GlyAla: 4.996 ± 0.088
0.584GlyCys: 0.584 ± 0.033
3.766GlyAsp: 3.766 ± 0.068
4.51GlyGlu: 4.51 ± 0.069
3.683GlyPhe: 3.683 ± 0.058
5.252GlyGly: 5.252 ± 0.097
1.181GlyHis: 1.181 ± 0.031
5.063GlyIle: 5.063 ± 0.067
4.649GlyLys: 4.649 ± 0.064
6.521GlyLeu: 6.521 ± 0.082
1.76GlyMet: 1.76 ± 0.039
3.675GlyAsn: 3.675 ± 0.063
1.66GlyPro: 1.66 ± 0.052
2.528GlyGln: 2.528 ± 0.044
2.602GlyArg: 2.602 ± 0.043
4.347GlySer: 4.347 ± 0.077
4.397GlyThr: 4.397 ± 0.107
4.931GlyVal: 4.931 ± 0.069
0.843GlyTrp: 0.843 ± 0.026
2.939GlyTyr: 2.939 ± 0.054
0.0GlyXaa: 0.0 ± 0.0
His
1.07HisAla: 1.07 ± 0.03
0.147HisCys: 0.147 ± 0.01
0.876HisAsp: 0.876 ± 0.025
1.085HisGlu: 1.085 ± 0.03
1.151HisPhe: 1.151 ± 0.03
1.212HisGly: 1.212 ± 0.032
0.476HisHis: 0.476 ± 0.019
1.274HisIle: 1.274 ± 0.031
1.026HisLys: 1.026 ± 0.027
1.744HisLeu: 1.744 ± 0.037
0.447HisMet: 0.447 ± 0.016
0.861HisAsn: 0.861 ± 0.028
0.874HisPro: 0.874 ± 0.028
0.701HisGln: 0.701 ± 0.017
0.707HisArg: 0.707 ± 0.021
1.042HisSer: 1.042 ± 0.028
0.974HisThr: 0.974 ± 0.027
0.995HisVal: 0.995 ± 0.022
0.265HisTrp: 0.265 ± 0.015
0.846HisTyr: 0.846 ± 0.026
0.0HisXaa: 0.0 ± 0.0
Ile
5.303IleAla: 5.303 ± 0.069
0.522IleCys: 0.522 ± 0.019
4.535IleAsp: 4.535 ± 0.06
5.063IleGlu: 5.063 ± 0.066
3.016IlePhe: 3.016 ± 0.051
5.074IleGly: 5.074 ± 0.068
1.253IleHis: 1.253 ± 0.031
4.421IleIle: 4.421 ± 0.07
4.303IleLys: 4.303 ± 0.063
5.66IleLeu: 5.66 ± 0.074
1.306IleMet: 1.306 ± 0.033
3.794IleAsn: 3.794 ± 0.054
2.87IlePro: 2.87 ± 0.042
2.273IleGln: 2.273 ± 0.047
2.633IleArg: 2.633 ± 0.041
4.926IleSer: 4.926 ± 0.07
4.218IleThr: 4.218 ± 0.078
4.181IleVal: 4.181 ± 0.06
0.68IleTrp: 0.68 ± 0.023
2.406IleTyr: 2.406 ± 0.041
0.0IleXaa: 0.0 ± 0.0
Lys
5.141LysAla: 5.141 ± 0.072
0.274LysCys: 0.274 ± 0.016
3.565LysAsp: 3.565 ± 0.057
5.176LysGlu: 5.176 ± 0.087
2.418LysPhe: 2.418 ± 0.044
4.175LysGly: 4.175 ± 0.058
1.29LysHis: 1.29 ± 0.032
3.926LysIle: 3.926 ± 0.058
4.839LysLys: 4.839 ± 0.078
6.133LysLeu: 6.133 ± 0.067
1.583LysMet: 1.583 ± 0.034
3.256LysAsn: 3.256 ± 0.054
2.45LysPro: 2.45 ± 0.046
2.534LysGln: 2.534 ± 0.05
2.915LysArg: 2.915 ± 0.052
3.935LysSer: 3.935 ± 0.054
3.666LysThr: 3.666 ± 0.059
4.659LysVal: 4.659 ± 0.062
0.761LysTrp: 0.761 ± 0.02
2.451LysTyr: 2.451 ± 0.045
0.0LysXaa: 0.0 ± 0.0
Leu
7.115LeuAla: 7.115 ± 0.087
0.68LeuCys: 0.68 ± 0.025
5.089LeuAsp: 5.089 ± 0.059
6.148LeuGlu: 6.148 ± 0.083
4.644LeuPhe: 4.644 ± 0.073
6.272LeuGly: 6.272 ± 0.076
1.431LeuHis: 1.431 ± 0.032
6.52LeuIle: 6.52 ± 0.079
6.869LeuLys: 6.869 ± 0.101
9.004LeuLeu: 9.004 ± 0.119
2.252LeuMet: 2.252 ± 0.043
5.432LeuAsn: 5.432 ± 0.064
3.716LeuPro: 3.716 ± 0.052
3.075LeuGln: 3.075 ± 0.052
3.619LeuArg: 3.619 ± 0.055
7.069LeuSer: 7.069 ± 0.087
5.395LeuThr: 5.395 ± 0.068
6.221LeuVal: 6.221 ± 0.078
0.92LeuTrp: 0.92 ± 0.034
3.096LeuTyr: 3.096 ± 0.052
0.0LeuXaa: 0.0 ± 0.0
Met
1.993MetAla: 1.993 ± 0.045
0.12MetCys: 0.12 ± 0.01
1.314MetAsp: 1.314 ± 0.03
1.587MetGlu: 1.587 ± 0.034
0.842MetPhe: 0.842 ± 0.026
1.617MetGly: 1.617 ± 0.033
0.457MetHis: 0.457 ± 0.018
1.468MetIle: 1.468 ± 0.035
1.929MetLys: 1.929 ± 0.042
2.208MetLeu: 2.208 ± 0.039
0.61MetMet: 0.61 ± 0.021
1.28MetAsn: 1.28 ± 0.036
1.008MetPro: 1.008 ± 0.026
0.831MetGln: 0.831 ± 0.025
1.074MetArg: 1.074 ± 0.026
1.536MetSer: 1.536 ± 0.037
1.195MetThr: 1.195 ± 0.033
1.579MetVal: 1.579 ± 0.036
0.193MetTrp: 0.193 ± 0.013
0.627MetTyr: 0.627 ± 0.024
0.0MetXaa: 0.0 ± 0.0
Asn
3.809AsnAla: 3.809 ± 0.057
0.338AsnCys: 0.338 ± 0.024
3.005AsnAsp: 3.005 ± 0.063
3.577AsnGlu: 3.577 ± 0.058
2.583AsnPhe: 2.583 ± 0.049
4.297AsnGly: 4.297 ± 0.08
0.949AsnHis: 0.949 ± 0.024
3.568AsnIle: 3.568 ± 0.049
3.129AsnLys: 3.129 ± 0.044
4.776AsnLeu: 4.776 ± 0.062
1.178AsnMet: 1.178 ± 0.029
2.879AsnAsn: 2.879 ± 0.051
2.626AsnPro: 2.626 ± 0.05
2.123AsnGln: 2.123 ± 0.042
2.251AsnArg: 2.251 ± 0.041
3.348AsnSer: 3.348 ± 0.055
3.129AsnThr: 3.129 ± 0.063
3.268AsnVal: 3.268 ± 0.06
0.775AsnTrp: 0.775 ± 0.023
2.376AsnTyr: 2.376 ± 0.037
0.0AsnXaa: 0.0 ± 0.0
Pro
2.572ProAla: 2.572 ± 0.051
0.182ProCys: 0.182 ± 0.012
2.278ProAsp: 2.278 ± 0.043
3.226ProGlu: 3.226 ± 0.05
1.928ProPhe: 1.928 ± 0.039
2.216ProGly: 2.216 ± 0.039
0.651ProHis: 0.651 ± 0.018
2.534ProIle: 2.534 ± 0.043
2.323ProLys: 2.323 ± 0.043
3.062ProLeu: 3.062 ± 0.044
0.806ProMet: 0.806 ± 0.025
2.25ProAsn: 2.25 ± 0.046
0.949ProPro: 0.949 ± 0.03
1.276ProGln: 1.276 ± 0.034
1.118ProArg: 1.118 ± 0.028
2.403ProSer: 2.403 ± 0.046
2.082ProThr: 2.082 ± 0.048
2.544ProVal: 2.544 ± 0.041
0.457ProTrp: 0.457 ± 0.018
1.466ProTyr: 1.466 ± 0.039
0.0ProXaa: 0.0 ± 0.0
Gln
2.678GlnAla: 2.678 ± 0.039
0.155GlnCys: 0.155 ± 0.011
1.645GlnAsp: 1.645 ± 0.038
2.477GlnGlu: 2.477 ± 0.043
1.901GlnPhe: 1.901 ± 0.04
2.087GlnGly: 2.087 ± 0.038
0.68GlnHis: 0.68 ± 0.024
2.497GlnIle: 2.497 ± 0.043
2.466GlnLys: 2.466 ± 0.046
3.815GlnLeu: 3.815 ± 0.061
0.967GlnMet: 0.967 ± 0.028
1.979GlnAsn: 1.979 ± 0.043
1.35GlnPro: 1.35 ± 0.033
1.777GlnGln: 1.777 ± 0.047
1.561GlnArg: 1.561 ± 0.034
2.164GlnSer: 2.164 ± 0.037
2.097GlnThr: 2.097 ± 0.037
2.553GlnVal: 2.553 ± 0.039
0.439GlnTrp: 0.439 ± 0.018
1.37GlnTyr: 1.37 ± 0.032
0.0GlnXaa: 0.0 ± 0.0
Arg
2.552ArgAla: 2.552 ± 0.038
0.188ArgCys: 0.188 ± 0.014
1.95ArgAsp: 1.95 ± 0.039
2.457ArgGlu: 2.457 ± 0.046
2.179ArgPhe: 2.179 ± 0.036
2.36ArgGly: 2.36 ± 0.051
0.639ArgHis: 0.639 ± 0.021
2.939ArgIle: 2.939 ± 0.039
2.86ArgLys: 2.86 ± 0.052
3.837ArgLeu: 3.837 ± 0.057
1.165ArgMet: 1.165 ± 0.029
2.134ArgAsn: 2.134 ± 0.039
1.357ArgPro: 1.357 ± 0.031
1.376ArgGln: 1.376 ± 0.036
1.655ArgArg: 1.655 ± 0.043
2.323ArgSer: 2.323 ± 0.044
2.098ArgThr: 2.098 ± 0.04
2.718ArgVal: 2.718 ± 0.046
0.472ArgTrp: 0.472 ± 0.018
1.635ArgTyr: 1.635 ± 0.037
0.0ArgXaa: 0.0 ± 0.0
Ser
4.55SerAla: 4.55 ± 0.069
0.475SerCys: 0.475 ± 0.017
3.513SerAsp: 3.513 ± 0.058
4.12SerGlu: 4.12 ± 0.053
3.8SerPhe: 3.8 ± 0.056
5.009SerGly: 5.009 ± 0.081
1.072SerHis: 1.072 ± 0.03
4.834SerIle: 4.834 ± 0.071
3.852SerLys: 3.852 ± 0.066
6.349SerLeu: 6.349 ± 0.078
1.386SerMet: 1.386 ± 0.036
3.293SerAsn: 3.293 ± 0.06
2.392SerPro: 2.392 ± 0.044
2.222SerGln: 2.222 ± 0.043
2.369SerArg: 2.369 ± 0.047
4.173SerSer: 4.173 ± 0.067
3.802SerThr: 3.802 ± 0.057
4.162SerVal: 4.162 ± 0.056
0.756SerTrp: 0.756 ± 0.024
2.533SerTyr: 2.533 ± 0.047
0.0SerXaa: 0.0 ± 0.0
Thr
4.359ThrAla: 4.359 ± 0.093
0.332ThrCys: 0.332 ± 0.021
3.457ThrAsp: 3.457 ± 0.061
3.524ThrGlu: 3.524 ± 0.053
3.019ThrPhe: 3.019 ± 0.058
4.232ThrGly: 4.232 ± 0.077
1.01ThrHis: 1.01 ± 0.028
4.213ThrIle: 4.213 ± 0.073
3.077ThrLys: 3.077 ± 0.047
5.543ThrLeu: 5.543 ± 0.066
1.002ThrMet: 1.002 ± 0.028
2.897ThrAsn: 2.897 ± 0.061
2.477ThrPro: 2.477 ± 0.044
1.85ThrGln: 1.85 ± 0.037
1.8ThrArg: 1.8 ± 0.033
3.495ThrSer: 3.495 ± 0.062
3.291ThrThr: 3.291 ± 0.055
4.041ThrVal: 4.041 ± 0.086
0.714ThrTrp: 0.714 ± 0.03
2.374ThrTyr: 2.374 ± 0.052
0.0ThrXaa: 0.0 ± 0.0
Val
4.888ValAla: 4.888 ± 0.071
0.488ValCys: 0.488 ± 0.021
3.918ValAsp: 3.918 ± 0.061
4.369ValGlu: 4.369 ± 0.058
3.432ValPhe: 3.432 ± 0.05
4.374ValGly: 4.374 ± 0.059
1.095ValHis: 1.095 ± 0.03
4.505ValIle: 4.505 ± 0.059
4.061ValLys: 4.061 ± 0.054
6.42ValLeu: 6.42 ± 0.073
1.53ValMet: 1.53 ± 0.035
3.671ValAsn: 3.671 ± 0.054
2.334ValPro: 2.334 ± 0.047
2.081ValGln: 2.081 ± 0.038
2.499ValArg: 2.499 ± 0.049
4.8ValSer: 4.8 ± 0.075
3.996ValThr: 3.996 ± 0.108
4.839ValVal: 4.839 ± 0.075
0.733ValTrp: 0.733 ± 0.022
2.445ValTyr: 2.445 ± 0.043
0.0ValXaa: 0.0 ± 0.0
Trp
0.774TrpAla: 0.774 ± 0.026
0.095TrpCys: 0.095 ± 0.009
0.672TrpAsp: 0.672 ± 0.027
0.77TrpGlu: 0.77 ± 0.022
0.566TrpPhe: 0.566 ± 0.022
0.784TrpGly: 0.784 ± 0.028
0.242TrpHis: 0.242 ± 0.015
0.641TrpIle: 0.641 ± 0.023
0.741TrpLys: 0.741 ± 0.03
1.18TrpLeu: 1.18 ± 0.028
0.34TrpMet: 0.34 ± 0.015
0.705TrpAsn: 0.705 ± 0.025
0.343TrpPro: 0.343 ± 0.016
0.547TrpGln: 0.547 ± 0.024
0.521TrpArg: 0.521 ± 0.021
0.759TrpSer: 0.759 ± 0.027
0.634TrpThr: 0.634 ± 0.026
0.813TrpVal: 0.813 ± 0.028
0.182TrpTrp: 0.182 ± 0.014
0.439TrpTyr: 0.439 ± 0.019
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.567TyrAla: 2.567 ± 0.042
0.281TyrCys: 0.281 ± 0.015
2.324TyrAsp: 2.324 ± 0.044
2.459TyrGlu: 2.459 ± 0.041
2.272TyrPhe: 2.272 ± 0.042
2.73TyrGly: 2.73 ± 0.056
0.824TyrHis: 0.824 ± 0.024
2.184TyrIle: 2.184 ± 0.041
2.28TyrLys: 2.28 ± 0.04
3.778TyrLeu: 3.778 ± 0.055
0.851TyrMet: 0.851 ± 0.027
2.133TyrAsn: 2.133 ± 0.044
1.476TyrPro: 1.476 ± 0.03
1.626TyrGln: 1.626 ± 0.033
1.796TyrArg: 1.796 ± 0.036
2.643TyrSer: 2.643 ± 0.047
2.273TyrThr: 2.273 ± 0.051
2.176TyrVal: 2.176 ± 0.044
0.525TyrTrp: 0.525 ± 0.021
1.804TyrTyr: 1.804 ± 0.04
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4016 proteins (1425172 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski