Amino acid dipepetide frequency for Bythopirellula polymerisocia

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	10.034AlaAla: 10.034 ± 0.102	1.106AlaCys: 1.106 ± 0.027	5.458AlaAsp: 5.458 ± 0.06	6.529AlaGlu: 6.529 ± 0.073	3.223AlaPhe: 3.223 ± 0.046	7.651AlaGly: 7.651 ± 0.086	1.609AlaHis: 1.609 ± 0.03	5.543AlaIle: 5.543 ± 0.065	3.647AlaLys: 3.647 ± 0.058	8.681AlaLeu: 8.681 ± 0.092	2.291AlaMet: 2.291 ± 0.034	3.422AlaAsn: 3.422 ± 0.056	3.576AlaPro: 3.576 ± 0.048	3.356AlaGln: 3.356 ± 0.046	5.004AlaArg: 5.004 ± 0.062	6.026AlaSer: 6.026 ± 0.067	5.607AlaThr: 5.607 ± 0.062	6.706AlaVal: 6.706 ± 0.073	1.367AlaTrp: 1.367 ± 0.035	2.107AlaTyr: 2.107 ± 0.034	0.0AlaXaa: 0.0 ± 0.0
Cys	0.866CysAla: 0.866 ± 0.026	0.306CysCys: 0.306 ± 0.029	0.744CysAsp: 0.744 ± 0.025	0.73CysGlu: 0.73 ± 0.021	0.462CysPhe: 0.462 ± 0.017	1.135CysGly: 1.135 ± 0.039	0.391CysHis: 0.391 ± 0.02	0.525CysIle: 0.525 ± 0.016	0.347CysLys: 0.347 ± 0.015	1.24CysLeu: 1.24 ± 0.027	0.198CysMet: 0.198 ± 0.011	0.344CysAsn: 0.344 ± 0.015	0.627CysPro: 0.627 ± 0.021	0.502CysGln: 0.502 ± 0.019	0.806CysArg: 0.806 ± 0.022	0.744CysSer: 0.744 ± 0.024	0.575CysThr: 0.575 ± 0.018	0.776CysVal: 0.776 ± 0.022	0.19CysTrp: 0.19 ± 0.01	0.338CysTyr: 0.338 ± 0.018	0.0CysXaa: 0.0 ± 0.0
Asp	4.931AspAla: 4.931 ± 0.06	0.652AspCys: 0.652 ± 0.022	3.206AspAsp: 3.206 ± 0.057	3.731AspGlu: 3.731 ± 0.048	2.776AspPhe: 2.776 ± 0.045	5.138AspGly: 5.138 ± 0.08	1.253AspHis: 1.253 ± 0.025	2.688AspIle: 2.688 ± 0.038	1.876AspLys: 1.876 ± 0.035	5.734AspLeu: 5.734 ± 0.068	1.096AspMet: 1.096 ± 0.025	1.904AspAsn: 1.904 ± 0.035	3.381AspPro: 3.381 ± 0.053	2.219AspGln: 2.219 ± 0.038	3.478AspArg: 3.478 ± 0.052	3.785AspSer: 3.785 ± 0.053	2.695AspThr: 2.695 ± 0.045	3.911AspVal: 3.911 ± 0.052	1.125AspTrp: 1.125 ± 0.028	1.722AspTyr: 1.722 ± 0.038	0.0AspXaa: 0.0 ± 0.0
Glu	5.594GluAla: 5.594 ± 0.064	0.574GluCys: 0.574 ± 0.019	2.926GluAsp: 2.926 ± 0.046	4.049GluGlu: 4.049 ± 0.076	2.511GluPhe: 2.511 ± 0.038	3.992GluGly: 3.992 ± 0.054	1.388GluHis: 1.388 ± 0.035	3.761GluIle: 3.761 ± 0.045	2.824GluLys: 2.824 ± 0.043	6.914GluLeu: 6.914 ± 0.078	1.595GluMet: 1.595 ± 0.031	2.284GluAsn: 2.284 ± 0.034	2.919GluPro: 2.919 ± 0.047	3.044GluGln: 3.044 ± 0.044	3.899GluArg: 3.899 ± 0.061	4.109GluSer: 4.109 ± 0.052	3.309GluThr: 3.309 ± 0.046	4.582GluVal: 4.582 ± 0.061	0.865GluTrp: 0.865 ± 0.026	1.586GluTyr: 1.586 ± 0.031	0.0GluXaa: 0.0 ± 0.0
Phe	3.818PheAla: 3.818 ± 0.05	0.548PheCys: 0.548 ± 0.018	2.993PheAsp: 2.993 ± 0.046	2.35PheGlu: 2.35 ± 0.039	1.597PhePhe: 1.597 ± 0.033	3.451PheGly: 3.451 ± 0.05	0.83PheHis: 0.83 ± 0.021	1.63PheIle: 1.63 ± 0.036	1.023PheLys: 1.023 ± 0.026	3.89PheLeu: 3.89 ± 0.05	0.757PheMet: 0.757 ± 0.023	1.475PheAsn: 1.475 ± 0.034	1.723PhePro: 1.723 ± 0.028	1.378PheGln: 1.378 ± 0.029	2.232PheArg: 2.232 ± 0.038	2.781PheSer: 2.781 ± 0.042	2.205PheThr: 2.205 ± 0.039	2.961PheVal: 2.961 ± 0.049	0.593PheTrp: 0.593 ± 0.018	1.069PheTyr: 1.069 ± 0.022	0.001PheXaa: 0.001 ± 0.001
Gly	6.184GlyAla: 6.184 ± 0.068	1.026GlyCys: 1.026 ± 0.035	4.811GlyAsp: 4.811 ± 0.071	4.702GlyGlu: 4.702 ± 0.065	3.21GlyPhe: 3.21 ± 0.048	6.939GlyGly: 6.939 ± 0.128	1.683GlyHis: 1.683 ± 0.033	4.628GlyIle: 4.628 ± 0.055	3.594GlyLys: 3.594 ± 0.05	7.257GlyLeu: 7.257 ± 0.067	2.031GlyMet: 2.031 ± 0.042	3.248GlyAsn: 3.248 ± 0.071	3.142GlyPro: 3.142 ± 0.05	3.033GlyGln: 3.033 ± 0.05	4.343GlyArg: 4.343 ± 0.056	5.52GlySer: 5.52 ± 0.082	5.131GlyThr: 5.131 ± 0.096	5.544GlyVal: 5.544 ± 0.062	1.337GlyTrp: 1.337 ± 0.029	2.27GlyTyr: 2.27 ± 0.038	0.0GlyXaa: 0.0 ± 0.0
His	1.822HisAla: 1.822 ± 0.032	0.327HisCys: 0.327 ± 0.013	1.244HisAsp: 1.244 ± 0.026	1.29HisGlu: 1.29 ± 0.028	1.022HisPhe: 1.022 ± 0.02	1.7HisGly: 1.7 ± 0.036	0.639HisHis: 0.639 ± 0.018	0.939HisIle: 0.939 ± 0.023	0.622HisLys: 0.622 ± 0.019	2.244HisLeu: 2.244 ± 0.04	0.384HisMet: 0.384 ± 0.015	0.694HisAsn: 0.694 ± 0.02	1.288HisPro: 1.288 ± 0.029	0.848HisGln: 0.848 ± 0.023	1.395HisArg: 1.395 ± 0.026	1.334HisSer: 1.334 ± 0.027	1.062HisThr: 1.062 ± 0.023	1.494HisVal: 1.494 ± 0.027	0.427HisTrp: 0.427 ± 0.018	0.665HisTyr: 0.665 ± 0.018	0.0HisXaa: 0.0 ± 0.0
Ile	5.825IleAla: 5.825 ± 0.059	0.715IleCys: 0.715 ± 0.022	3.804IleAsp: 3.804 ± 0.05	3.618IleGlu: 3.618 ± 0.046	1.629IlePhe: 1.629 ± 0.034	4.311IleGly: 4.311 ± 0.06	1.087IleHis: 1.087 ± 0.027	2.109IleIle: 2.109 ± 0.04	1.583IleLys: 1.583 ± 0.033	4.665IleLeu: 4.665 ± 0.059	0.838IleMet: 0.838 ± 0.022	1.891IleAsn: 1.891 ± 0.04	2.702IlePro: 2.702 ± 0.038	1.709IleGln: 1.709 ± 0.031	3.09IleArg: 3.09 ± 0.042	3.462IleSer: 3.462 ± 0.051	2.946IleThr: 2.946 ± 0.048	4.112IleVal: 4.112 ± 0.053	0.685IleTrp: 0.685 ± 0.018	1.361IleTyr: 1.361 ± 0.03	0.0IleXaa: 0.0 ± 0.0
Lys	2.82LysAla: 2.82 ± 0.044	0.376LysCys: 0.376 ± 0.017	1.601LysAsp: 1.601 ± 0.035	2.123LysGlu: 2.123 ± 0.042	1.283LysPhe: 1.283 ± 0.025	2.12LysGly: 2.12 ± 0.036	0.898LysHis: 0.898 ± 0.022	2.041LysIle: 2.041 ± 0.038	1.837LysLys: 1.837 ± 0.056	4.022LysLeu: 4.022 ± 0.054	0.903LysMet: 0.903 ± 0.023	1.362LysAsn: 1.362 ± 0.028	2.059LysPro: 2.059 ± 0.043	1.81LysGln: 1.81 ± 0.036	2.187LysArg: 2.187 ± 0.04	2.5LysSer: 2.5 ± 0.04	1.99LysThr: 1.99 ± 0.035	2.506LysVal: 2.506 ± 0.038	0.558LysTrp: 0.558 ± 0.019	1.043LysTyr: 1.043 ± 0.031	0.0LysXaa: 0.0 ± 0.0
Leu	11.508LeuAla: 11.508 ± 0.093	1.197LeuCys: 1.197 ± 0.03	5.726LeuAsp: 5.726 ± 0.063	6.095LeuGlu: 6.095 ± 0.069	3.736LeuPhe: 3.736 ± 0.047	7.901LeuGly: 7.901 ± 0.076	1.919LeuHis: 1.919 ± 0.037	4.81LeuIle: 4.81 ± 0.06	3.518LeuLys: 3.518 ± 0.042	10.723LeuLeu: 10.723 ± 0.107	2.063LeuMet: 2.063 ± 0.042	3.401LeuAsn: 3.401 ± 0.048	5.386LeuPro: 5.386 ± 0.059	3.568LeuGln: 3.568 ± 0.05	6.112LeuArg: 6.112 ± 0.062	7.04LeuSer: 7.04 ± 0.073	5.891LeuThr: 5.891 ± 0.062	7.815LeuVal: 7.815 ± 0.075	1.321LeuTrp: 1.321 ± 0.03	2.19LeuTyr: 2.19 ± 0.039	0.0LeuXaa: 0.0 ± 0.0
Met	2.162MetAla: 2.162 ± 0.043	0.238MetCys: 0.238 ± 0.011	0.935MetAsp: 0.935 ± 0.023	1.125MetGlu: 1.125 ± 0.026	0.789MetPhe: 0.789 ± 0.021	1.485MetGly: 1.485 ± 0.032	0.466MetHis: 0.466 ± 0.017	1.182MetIle: 1.182 ± 0.025	0.961MetLys: 0.961 ± 0.025	2.392MetLeu: 2.392 ± 0.041	0.506MetMet: 0.506 ± 0.019	0.897MetAsn: 0.897 ± 0.023	1.221MetPro: 1.221 ± 0.026	0.965MetGln: 0.965 ± 0.025	1.331MetArg: 1.331 ± 0.025	1.589MetSer: 1.589 ± 0.032	1.326MetThr: 1.326 ± 0.027	1.504MetVal: 1.504 ± 0.028	0.25MetTrp: 0.25 ± 0.011	0.401MetTyr: 0.401 ± 0.015	0.0MetXaa: 0.0 ± 0.0
Asn	2.908AsnAla: 2.908 ± 0.048	0.439AsnCys: 0.439 ± 0.018	2.011AsnAsp: 2.011 ± 0.04	2.026AsnGlu: 2.026 ± 0.038	1.54AsnPhe: 1.54 ± 0.031	3.188AsnGly: 3.188 ± 0.064	0.821AsnHis: 0.821 ± 0.019	1.773AsnIle: 1.773 ± 0.041	1.015AsnLys: 1.015 ± 0.025	3.712AsnLeu: 3.712 ± 0.05	0.67AsnMet: 0.67 ± 0.02	1.478AsnAsn: 1.478 ± 0.038	2.239AsnPro: 2.239 ± 0.033	1.438AsnGln: 1.438 ± 0.03	2.216AsnArg: 2.216 ± 0.038	2.732AsnSer: 2.732 ± 0.061	1.924AsnThr: 1.924 ± 0.043	2.539AsnVal: 2.539 ± 0.049	0.703AsnTrp: 0.703 ± 0.022	1.162AsnTyr: 1.162 ± 0.031	0.0AsnXaa: 0.0 ± 0.0
Pro	4.632ProAla: 4.632 ± 0.057	0.434ProCys: 0.434 ± 0.017	2.946ProAsp: 2.946 ± 0.048	3.79ProGlu: 3.79 ± 0.054	1.809ProPhe: 1.809 ± 0.035	4.18ProGly: 4.18 ± 0.053	1.084ProHis: 1.084 ± 0.024	2.457ProIle: 2.457 ± 0.043	1.635ProLys: 1.635 ± 0.031	4.861ProLeu: 4.861 ± 0.059	0.97ProMet: 0.97 ± 0.022	1.976ProAsn: 1.976 ± 0.039	2.575ProPro: 2.575 ± 0.045	2.129ProGln: 2.129 ± 0.034	2.553ProArg: 2.553 ± 0.038	3.376ProSer: 3.376 ± 0.045	3.051ProThr: 3.051 ± 0.048	3.491ProVal: 3.491 ± 0.046	0.752ProTrp: 0.752 ± 0.023	1.195ProTyr: 1.195 ± 0.027	0.0ProXaa: 0.0 ± 0.0
Gln	3.877GlnAla: 3.877 ± 0.049	0.387GlnCys: 0.387 ± 0.012	1.735GlnAsp: 1.735 ± 0.033	2.385GlnGlu: 2.385 ± 0.036	1.647GlnPhe: 1.647 ± 0.033	2.677GlnGly: 2.677 ± 0.039	0.899GlnHis: 0.899 ± 0.021	2.337GlnIle: 2.337 ± 0.04	1.368GlnLys: 1.368 ± 0.031	4.854GlnLeu: 4.854 ± 0.051	0.922GlnMet: 0.922 ± 0.024	1.303GlnAsn: 1.303 ± 0.03	2.023GlnPro: 2.023 ± 0.032	2.147GlnGln: 2.147 ± 0.048	2.703GlnArg: 2.703 ± 0.041	2.577GlnSer: 2.577 ± 0.044	2.083GlnThr: 2.083 ± 0.036	2.891GlnVal: 2.891 ± 0.04	0.635GlnTrp: 0.635 ± 0.021	0.977GlnTyr: 0.977 ± 0.022	0.0GlnXaa: 0.0 ± 0.0
Arg	4.421ArgAla: 4.421 ± 0.054	0.657ArgCys: 0.657 ± 0.021	3.26ArgAsp: 3.26 ± 0.047	4.057ArgGlu: 4.057 ± 0.063	2.556ArgPhe: 2.556 ± 0.037	4.003ArgGly: 4.003 ± 0.051	1.373ArgHis: 1.373 ± 0.027	3.491ArgIle: 3.491 ± 0.049	2.36ArgLys: 2.36 ± 0.041	6.316ArgLeu: 6.316 ± 0.069	1.556ArgMet: 1.556 ± 0.032	2.062ArgAsn: 2.062 ± 0.036	2.601ArgPro: 2.601 ± 0.055	2.721ArgGln: 2.721 ± 0.042	4.379ArgArg: 4.379 ± 0.057	3.621ArgSer: 3.621 ± 0.048	3.021ArgThr: 3.021 ± 0.041	4.088ArgVal: 4.088 ± 0.053	1.049ArgTrp: 1.049 ± 0.028	1.718ArgTyr: 1.718 ± 0.032	0.0ArgXaa: 0.0 ± 0.0
Ser	5.955SerAla: 5.955 ± 0.068	0.757SerCys: 0.757 ± 0.024	3.757SerAsp: 3.757 ± 0.055	3.985SerGlu: 3.985 ± 0.053	2.662SerPhe: 2.662 ± 0.042	5.777SerGly: 5.777 ± 0.09	1.44SerHis: 1.44 ± 0.029	3.492SerIle: 3.492 ± 0.049	2.317SerLys: 2.317 ± 0.043	6.921SerLeu: 6.921 ± 0.067	1.421SerMet: 1.421 ± 0.031	2.518SerAsn: 2.518 ± 0.044	3.677SerPro: 3.677 ± 0.051	2.93SerGln: 2.93 ± 0.049	3.805SerArg: 3.805 ± 0.053	4.796SerSer: 4.796 ± 0.063	3.92SerThr: 3.92 ± 0.063	4.466SerVal: 4.466 ± 0.057	0.985SerTrp: 0.985 ± 0.023	1.66SerTyr: 1.66 ± 0.033	0.0SerXaa: 0.0 ± 0.0
Thr	5.19ThrAla: 5.19 ± 0.068	0.624ThrCys: 0.624 ± 0.02	3.054ThrAsp: 3.054 ± 0.041	2.984ThrGlu: 2.984 ± 0.045	2.268ThrPhe: 2.268 ± 0.047	5.019ThrGly: 5.019 ± 0.077	1.159ThrHis: 1.159 ± 0.028	3.39ThrIle: 3.39 ± 0.052	1.872ThrLys: 1.872 ± 0.034	5.928ThrLeu: 5.928 ± 0.08	1.125ThrMet: 1.125 ± 0.028	2.204ThrAsn: 2.204 ± 0.045	3.18ThrPro: 3.18 ± 0.051	1.9ThrGln: 1.9 ± 0.04	2.718ThrArg: 2.718 ± 0.045	3.886ThrSer: 3.886 ± 0.059	3.435ThrThr: 3.435 ± 0.053	4.143ThrVal: 4.143 ± 0.062	0.86ThrTrp: 0.86 ± 0.023	1.447ThrTyr: 1.447 ± 0.034	0.0ThrXaa: 0.0 ± 0.0
Val	7.167ValAla: 7.167 ± 0.062	0.902ValCys: 0.902 ± 0.027	4.545ValAsp: 4.545 ± 0.054	4.766ValGlu: 4.766 ± 0.066	2.784ValPhe: 2.784 ± 0.045	5.702ValGly: 5.702 ± 0.062	1.403ValHis: 1.403 ± 0.029	3.581ValIle: 3.581 ± 0.05	2.257ValLys: 2.257 ± 0.037	7.136ValLeu: 7.136 ± 0.072	1.532ValMet: 1.532 ± 0.033	2.498ValAsn: 2.498 ± 0.047	3.68ValPro: 3.68 ± 0.052	2.411ValGln: 2.411 ± 0.035	4.2ValArg: 4.2 ± 0.054	4.678ValSer: 4.678 ± 0.06	4.178ValThr: 4.178 ± 0.056	5.709ValVal: 5.709 ± 0.065	1.022ValTrp: 1.022 ± 0.025	1.667ValTyr: 1.667 ± 0.034	0.0ValXaa: 0.0 ± 0.0
Trp	1.071TrpAla: 1.071 ± 0.025	0.208TrpCys: 0.208 ± 0.01	0.829TrpAsp: 0.829 ± 0.025	0.765TrpGlu: 0.765 ± 0.023	0.617TrpPhe: 0.617 ± 0.019	1.046TrpGly: 1.046 ± 0.024	0.46TrpHis: 0.46 ± 0.017	0.848TrpIle: 0.848 ± 0.02	0.66TrpLys: 0.66 ± 0.021	1.685TrpLeu: 1.685 ± 0.033	0.391TrpMet: 0.391 ± 0.015	0.696TrpAsn: 0.696 ± 0.022	0.689TrpPro: 0.689 ± 0.019	1.108TrpGln: 1.108 ± 0.031	0.953TrpArg: 0.953 ± 0.024	1.014TrpSer: 1.014 ± 0.026	0.809TrpThr: 0.809 ± 0.023	0.913TrpVal: 0.913 ± 0.022	0.332TrpTrp: 0.332 ± 0.016	0.421TrpTyr: 0.421 ± 0.018	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.157TyrAla: 2.157 ± 0.038	0.374TyrCys: 0.374 ± 0.015	1.714TyrAsp: 1.714 ± 0.034	1.626TyrGlu: 1.626 ± 0.035	1.184TyrPhe: 1.184 ± 0.031	2.22TyrGly: 2.22 ± 0.034	0.639TyrHis: 0.639 ± 0.019	0.916TyrIle: 0.916 ± 0.024	0.722TyrLys: 0.722 ± 0.023	2.746TyrLeu: 2.746 ± 0.042	0.477TyrMet: 0.477 ± 0.018	0.879TyrAsn: 0.879 ± 0.026	1.208TyrPro: 1.208 ± 0.028	1.21TyrGln: 1.21 ± 0.028	1.908TyrArg: 1.908 ± 0.037	1.67TyrSer: 1.67 ± 0.028	1.225TyrThr: 1.225 ± 0.028	1.667TyrVal: 1.667 ± 0.031	0.456TyrTrp: 0.456 ± 0.019	0.86TyrTyr: 0.86 ± 0.025	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.001XaaLys: 0.001 ± 0.001	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 5040 proteins (1770376 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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