Amino acid dipepetide frequency for Mycetocola lacteus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	18.877AlaAla: 18.877 ± 0.313	0.566AlaCys: 0.566 ± 0.027	7.359AlaAsp: 7.359 ± 0.104	8.492AlaGlu: 8.492 ± 0.11	3.772AlaPhe: 3.772 ± 0.073	12.197AlaGly: 12.197 ± 0.124	2.522AlaHis: 2.522 ± 0.059	6.316AlaIle: 6.316 ± 0.088	2.84AlaLys: 2.84 ± 0.071	14.81AlaLeu: 14.81 ± 0.17	2.375AlaMet: 2.375 ± 0.047	2.658AlaAsn: 2.658 ± 0.105	6.584AlaPro: 6.584 ± 0.122	4.079AlaGln: 4.079 ± 0.07	8.643AlaArg: 8.643 ± 0.138	7.045AlaSer: 7.045 ± 0.111	7.809AlaThr: 7.809 ± 0.155	9.745AlaVal: 9.745 ± 0.111	1.618AlaTrp: 1.618 ± 0.049	2.157AlaTyr: 2.157 ± 0.046	0.0AlaXaa: 0.0 ± 0.0
Cys	0.672CysAla: 0.672 ± 0.029	0.032CysCys: 0.032 ± 0.006	0.25CysAsp: 0.25 ± 0.017	0.242CysGlu: 0.242 ± 0.018	0.139CysPhe: 0.139 ± 0.012	0.518CysGly: 0.518 ± 0.023	0.087CysHis: 0.087 ± 0.009	0.17CysIle: 0.17 ± 0.014	0.07CysLys: 0.07 ± 0.008	0.415CysLeu: 0.415 ± 0.022	0.081CysMet: 0.081 ± 0.011	0.1CysAsn: 0.1 ± 0.011	0.267CysPro: 0.267 ± 0.018	0.113CysGln: 0.113 ± 0.013	0.262CysArg: 0.262 ± 0.015	0.3CysSer: 0.3 ± 0.022	0.375CysThr: 0.375 ± 0.024	0.417CysVal: 0.417 ± 0.021	0.051CysTrp: 0.051 ± 0.007	0.088CysTyr: 0.088 ± 0.009	0.0CysXaa: 0.0 ± 0.0
Asp	7.54AspAla: 7.54 ± 0.101	0.219AspCys: 0.219 ± 0.014	2.497AspAsp: 2.497 ± 0.065	3.366AspGlu: 3.366 ± 0.065	1.758AspPhe: 1.758 ± 0.042	4.917AspGly: 4.917 ± 0.091	1.068AspHis: 1.068 ± 0.031	2.441AspIle: 2.441 ± 0.044	1.098AspLys: 1.098 ± 0.039	5.88AspLeu: 5.88 ± 0.086	0.741AspMet: 0.741 ± 0.027	1.246AspAsn: 1.246 ± 0.044	4.311AspPro: 4.311 ± 0.082	1.685AspGln: 1.685 ± 0.049	3.888AspArg: 3.888 ± 0.073	2.795AspSer: 2.795 ± 0.059	3.38AspThr: 3.38 ± 0.067	4.168AspVal: 4.168 ± 0.065	0.807AspTrp: 0.807 ± 0.032	1.229AspTyr: 1.229 ± 0.042	0.0AspXaa: 0.0 ± 0.0
Glu	6.811GluAla: 6.811 ± 0.092	0.23GluCys: 0.23 ± 0.017	2.785GluAsp: 2.785 ± 0.06	2.732GluGlu: 2.732 ± 0.062	1.873GluPhe: 1.873 ± 0.047	3.831GluGly: 3.831 ± 0.072	1.468GluHis: 1.468 ± 0.044	3.145GluIle: 3.145 ± 0.053	1.517GluLys: 1.517 ± 0.049	6.371GluLeu: 6.371 ± 0.093	0.859GluMet: 0.859 ± 0.03	1.756GluAsn: 1.756 ± 0.039	2.942GluPro: 2.942 ± 0.059	1.966GluGln: 1.966 ± 0.045	5.044GluArg: 5.044 ± 0.088	3.152GluSer: 3.152 ± 0.06	3.375GluThr: 3.375 ± 0.062	4.261GluVal: 4.261 ± 0.075	0.749GluTrp: 0.749 ± 0.027	1.219GluTyr: 1.219 ± 0.039	0.0GluXaa: 0.0 ± 0.0
Phe	4.315PheAla: 4.315 ± 0.075	0.157PheCys: 0.157 ± 0.013	2.232PheAsp: 2.232 ± 0.054	1.792PheGlu: 1.792 ± 0.039	1.122PhePhe: 1.122 ± 0.036	3.56PheGly: 3.56 ± 0.069	0.509PheHis: 0.509 ± 0.025	1.415PheIle: 1.415 ± 0.045	0.493PheLys: 0.493 ± 0.025	2.877PheLeu: 2.877 ± 0.058	0.442PheMet: 0.442 ± 0.022	0.785PheAsn: 0.785 ± 0.026	1.5PhePro: 1.5 ± 0.037	0.816PheGln: 0.816 ± 0.028	1.778PheArg: 1.778 ± 0.042	2.009PheSer: 2.009 ± 0.048	2.431PheThr: 2.431 ± 0.057	2.762PheVal: 2.762 ± 0.06	0.544PheTrp: 0.544 ± 0.025	0.658PheTyr: 0.658 ± 0.029	0.0PheXaa: 0.0 ± 0.0
Gly	10.48GlyAla: 10.48 ± 0.133	0.507GlyCys: 0.507 ± 0.023	4.577GlyAsp: 4.577 ± 0.082	5.102GlyGlu: 5.102 ± 0.088	3.455GlyPhe: 3.455 ± 0.063	7.401GlyGly: 7.401 ± 0.117	1.657GlyHis: 1.657 ± 0.044	5.465GlyIle: 5.465 ± 0.079	2.603GlyLys: 2.603 ± 0.064	9.11GlyLeu: 9.11 ± 0.121	1.745GlyMet: 1.745 ± 0.044	2.249GlyAsn: 2.249 ± 0.064	3.807GlyPro: 3.807 ± 0.068	2.581GlyGln: 2.581 ± 0.061	5.269GlyArg: 5.269 ± 0.081	5.799GlySer: 5.799 ± 0.089	6.711GlyThr: 6.711 ± 0.107	7.408GlyVal: 7.408 ± 0.088	1.507GlyTrp: 1.507 ± 0.044	2.283GlyTyr: 2.283 ± 0.054	0.0GlyXaa: 0.0 ± 0.0
His	2.251HisAla: 2.251 ± 0.054	0.104HisCys: 0.104 ± 0.011	1.08HisAsp: 1.08 ± 0.033	1.113HisGlu: 1.113 ± 0.034	0.568HisPhe: 0.568 ± 0.026	1.876HisGly: 1.876 ± 0.052	0.425HisHis: 0.425 ± 0.022	0.768HisIle: 0.768 ± 0.027	0.278HisLys: 0.278 ± 0.018	1.901HisLeu: 1.901 ± 0.049	0.276HisMet: 0.276 ± 0.017	0.489HisAsn: 0.489 ± 0.023	1.376HisPro: 1.376 ± 0.038	0.5HisGln: 0.5 ± 0.022	1.434HisArg: 1.434 ± 0.043	0.997HisSer: 0.997 ± 0.032	1.351HisThr: 1.351 ± 0.034	1.368HisVal: 1.368 ± 0.042	0.278HisTrp: 0.278 ± 0.017	0.414HisTyr: 0.414 ± 0.019	0.0HisXaa: 0.0 ± 0.0
Ile	7.593IleAla: 7.593 ± 0.103	0.263IleCys: 0.263 ± 0.016	3.174IleAsp: 3.174 ± 0.058	3.12IleGlu: 3.12 ± 0.064	1.462IlePhe: 1.462 ± 0.043	5.089IleGly: 5.089 ± 0.075	0.8IleHis: 0.8 ± 0.032	2.598IleIle: 2.598 ± 0.064	0.948IleLys: 0.948 ± 0.031	5.016IleLeu: 5.016 ± 0.087	0.74IleMet: 0.74 ± 0.027	1.354IleAsn: 1.354 ± 0.041	2.977IlePro: 2.977 ± 0.057	1.243IleGln: 1.243 ± 0.033	3.055IleArg: 3.055 ± 0.055	2.928IleSer: 2.928 ± 0.059	3.775IleThr: 3.775 ± 0.082	4.632IleVal: 4.632 ± 0.075	0.626IleTrp: 0.626 ± 0.024	0.884IleTyr: 0.884 ± 0.032	0.0IleXaa: 0.0 ± 0.0
Lys	2.254LysAla: 2.254 ± 0.058	0.082LysCys: 0.082 ± 0.009	1.238LysAsp: 1.238 ± 0.046	0.924LysGlu: 0.924 ± 0.035	0.651LysPhe: 0.651 ± 0.03	1.346LysGly: 1.346 ± 0.043	0.441LysHis: 0.441 ± 0.023	1.413LysIle: 1.413 ± 0.05	1.015LysLys: 1.015 ± 0.045	2.316LysLeu: 2.316 ± 0.054	0.501LysMet: 0.501 ± 0.021	0.827LysAsn: 0.827 ± 0.036	1.366LysPro: 1.366 ± 0.046	0.684LysGln: 0.684 ± 0.026	1.521LysArg: 1.521 ± 0.04	1.349LysSer: 1.349 ± 0.045	1.689LysThr: 1.689 ± 0.05	1.739LysVal: 1.739 ± 0.05	0.254LysTrp: 0.254 ± 0.019	0.489LysTyr: 0.489 ± 0.028	0.0LysXaa: 0.0 ± 0.0
Leu	14.629LeuAla: 14.629 ± 0.18	0.554LeuCys: 0.554 ± 0.027	6.252LeuAsp: 6.252 ± 0.097	4.956LeuGlu: 4.956 ± 0.08	2.997LeuPhe: 2.997 ± 0.059	10.008LeuGly: 10.008 ± 0.106	1.755LeuHis: 1.755 ± 0.046	5.745LeuIle: 5.745 ± 0.097	1.91LeuLys: 1.91 ± 0.051	10.45LeuLeu: 10.45 ± 0.161	1.593LeuMet: 1.593 ± 0.041	2.516LeuAsn: 2.516 ± 0.059	5.743LeuPro: 5.743 ± 0.078	2.092LeuGln: 2.092 ± 0.048	7.18LeuArg: 7.18 ± 0.099	6.552LeuSer: 6.552 ± 0.077	6.937LeuThr: 6.937 ± 0.098	8.712LeuVal: 8.712 ± 0.111	1.212LeuTrp: 1.212 ± 0.035	1.72LeuTyr: 1.72 ± 0.046	0.0LeuXaa: 0.0 ± 0.0
Met	1.749MetAla: 1.749 ± 0.044	0.078MetCys: 0.078 ± 0.008	0.715MetAsp: 0.715 ± 0.027	0.581MetGlu: 0.581 ± 0.026	0.547MetPhe: 0.547 ± 0.023	1.193MetGly: 1.193 ± 0.038	0.277MetHis: 0.277 ± 0.017	1.029MetIle: 1.029 ± 0.033	0.424MetLys: 0.424 ± 0.022	1.757MetLeu: 1.757 ± 0.042	0.327MetMet: 0.327 ± 0.017	0.561MetAsn: 0.561 ± 0.022	0.948MetPro: 0.948 ± 0.032	0.431MetGln: 0.431 ± 0.02	1.216MetArg: 1.216 ± 0.034	1.557MetSer: 1.557 ± 0.039	1.521MetThr: 1.521 ± 0.042	1.349MetVal: 1.349 ± 0.037	0.173MetTrp: 0.173 ± 0.013	0.272MetTyr: 0.272 ± 0.017	0.0MetXaa: 0.0 ± 0.0
Asn	3.014AsnAla: 3.014 ± 0.089	0.114AsnCys: 0.114 ± 0.011	1.296AsnAsp: 1.296 ± 0.031	1.113AsnGlu: 1.113 ± 0.035	0.845AsnPhe: 0.845 ± 0.029	2.259AsnGly: 2.259 ± 0.063	0.418AsnHis: 0.418 ± 0.021	1.185AsnIle: 1.185 ± 0.035	0.597AsnLys: 0.597 ± 0.027	2.498AsnLeu: 2.498 ± 0.049	0.377AsnMet: 0.377 ± 0.019	0.739AsnAsn: 0.739 ± 0.031	2.086AsnPro: 2.086 ± 0.045	0.763AsnGln: 0.763 ± 0.033	1.581AsnArg: 1.581 ± 0.043	1.281AsnSer: 1.281 ± 0.037	1.767AsnThr: 1.767 ± 0.052	1.977AsnVal: 1.977 ± 0.051	0.41AsnTrp: 0.41 ± 0.02	0.607AsnTyr: 0.607 ± 0.026	0.0AsnXaa: 0.0 ± 0.0
Pro	7.893ProAla: 7.893 ± 0.133	0.165ProCys: 0.165 ± 0.016	3.356ProAsp: 3.356 ± 0.062	4.427ProGlu: 4.427 ± 0.076	1.593ProPhe: 1.593 ± 0.039	5.704ProGly: 5.704 ± 0.098	1.053ProHis: 1.053 ± 0.031	2.555ProIle: 2.555 ± 0.053	1.189ProLys: 1.189 ± 0.037	4.943ProLeu: 4.943 ± 0.073	0.814ProMet: 0.814 ± 0.031	1.352ProAsn: 1.352 ± 0.039	1.994ProPro: 1.994 ± 0.069	1.563ProGln: 1.563 ± 0.042	3.386ProArg: 3.386 ± 0.069	3.162ProSer: 3.162 ± 0.062	3.847ProThr: 3.847 ± 0.076	4.868ProVal: 4.868 ± 0.083	0.758ProTrp: 0.758 ± 0.026	0.94ProTyr: 0.94 ± 0.031	0.0ProXaa: 0.0 ± 0.0
Gln	3.606GlnAla: 3.606 ± 0.076	0.097GlnCys: 0.097 ± 0.011	1.305GlnAsp: 1.305 ± 0.037	1.225GlnGlu: 1.225 ± 0.033	0.772GlnPhe: 0.772 ± 0.027	2.135GlnGly: 2.135 ± 0.045	0.616GlnHis: 0.616 ± 0.025	1.8GlnIle: 1.8 ± 0.04	0.741GlnLys: 0.741 ± 0.026	2.842GlnLeu: 2.842 ± 0.062	0.504GlnMet: 0.504 ± 0.022	0.835GlnAsn: 0.835 ± 0.029	1.516GlnPro: 1.516 ± 0.046	1.012GlnGln: 1.012 ± 0.034	2.173GlnArg: 2.173 ± 0.053	1.602GlnSer: 1.602 ± 0.043	1.718GlnThr: 1.718 ± 0.044	2.291GlnVal: 2.291 ± 0.043	0.377GlnTrp: 0.377 ± 0.023	0.586GlnTyr: 0.586 ± 0.023	0.0GlnXaa: 0.0 ± 0.0
Arg	8.578ArgAla: 8.578 ± 0.117	0.263ArgCys: 0.263 ± 0.017	3.894ArgAsp: 3.894 ± 0.068	4.417ArgGlu: 4.417 ± 0.067	2.478ArgPhe: 2.478 ± 0.056	5.454ArgGly: 5.454 ± 0.089	1.341ArgHis: 1.341 ± 0.037	3.827ArgIle: 3.827 ± 0.072	1.392ArgLys: 1.392 ± 0.039	6.447ArgLeu: 6.447 ± 0.097	1.485ArgMet: 1.485 ± 0.039	1.511ArgAsn: 1.511 ± 0.042	3.244ArgPro: 3.244 ± 0.066	1.748ArgGln: 1.748 ± 0.048	5.349ArgArg: 5.349 ± 0.092	3.661ArgSer: 3.661 ± 0.053	4.143ArgThr: 4.143 ± 0.065	5.96ArgVal: 5.96 ± 0.095	1.049ArgTrp: 1.049 ± 0.034	1.563ArgTyr: 1.563 ± 0.043	0.0ArgXaa: 0.0 ± 0.0
Ser	8.109SerAla: 8.109 ± 0.129	0.282SerCys: 0.282 ± 0.02	3.024SerAsp: 3.024 ± 0.058	2.982SerGlu: 2.982 ± 0.062	1.984SerPhe: 1.984 ± 0.048	6.206SerGly: 6.206 ± 0.096	0.998SerHis: 0.998 ± 0.033	2.969SerIle: 2.969 ± 0.056	1.283SerLys: 1.283 ± 0.037	5.746SerLeu: 5.746 ± 0.075	1.094SerMet: 1.094 ± 0.032	1.291SerAsn: 1.291 ± 0.039	3.469SerPro: 3.469 ± 0.064	1.506SerGln: 1.506 ± 0.037	3.636SerArg: 3.636 ± 0.059	3.552SerSer: 3.552 ± 0.072	4.026SerThr: 4.026 ± 0.064	5.005SerVal: 5.005 ± 0.08	0.894SerTrp: 0.894 ± 0.03	1.145SerTyr: 1.145 ± 0.037	0.0SerXaa: 0.0 ± 0.0
Thr	8.181ThrAla: 8.181 ± 0.155	0.274ThrCys: 0.274 ± 0.019	3.588ThrAsp: 3.588 ± 0.067	3.842ThrGlu: 3.842 ± 0.067	1.986ThrPhe: 1.986 ± 0.047	6.475ThrGly: 6.475 ± 0.104	1.354ThrHis: 1.354 ± 0.038	3.222ThrIle: 3.222 ± 0.074	1.413ThrLys: 1.413 ± 0.049	7.245ThrLeu: 7.245 ± 0.098	0.901ThrMet: 0.901 ± 0.034	1.563ThrAsn: 1.563 ± 0.054	4.774ThrPro: 4.774 ± 0.105	1.756ThrGln: 1.756 ± 0.047	4.227ThrArg: 4.227 ± 0.063	3.756ThrSer: 3.756 ± 0.074	4.11ThrThr: 4.11 ± 0.084	6.132ThrVal: 6.132 ± 0.103	0.924ThrTrp: 0.924 ± 0.031	1.235ThrTyr: 1.235 ± 0.036	0.0ThrXaa: 0.0 ± 0.0
Val	10.154ValAla: 10.154 ± 0.113	0.469ValCys: 0.469 ± 0.02	4.59ValAsp: 4.59 ± 0.08	4.099ValGlu: 4.099 ± 0.072	2.949ValPhe: 2.949 ± 0.059	6.758ValGly: 6.758 ± 0.09	1.51ValHis: 1.51 ± 0.044	4.666ValIle: 4.666 ± 0.075	1.59ValLys: 1.59 ± 0.051	9.118ValLeu: 9.118 ± 0.099	1.332ValMet: 1.332 ± 0.042	2.069ValAsn: 2.069 ± 0.043	4.815ValPro: 4.815 ± 0.075	2.098ValGln: 2.098 ± 0.046	5.435ValArg: 5.435 ± 0.08	5.542ValSer: 5.542 ± 0.075	5.76ValThr: 5.76 ± 0.106	7.184ValVal: 7.184 ± 0.096	1.06ValTrp: 1.06 ± 0.033	1.436ValTyr: 1.436 ± 0.039	0.0ValXaa: 0.0 ± 0.0
Trp	1.488TrpAla: 1.488 ± 0.039	0.089TrpCys: 0.089 ± 0.008	0.718TrpAsp: 0.718 ± 0.027	0.617TrpGlu: 0.617 ± 0.027	0.518TrpPhe: 0.518 ± 0.027	1.05TrpGly: 1.05 ± 0.031	0.279TrpHis: 0.279 ± 0.015	0.864TrpIle: 0.864 ± 0.033	0.346TrpLys: 0.346 ± 0.018	1.531TrpLeu: 1.531 ± 0.048	0.265TrpMet: 0.265 ± 0.018	0.461TrpAsn: 0.461 ± 0.024	0.653TrpPro: 0.653 ± 0.025	0.49TrpGln: 0.49 ± 0.025	1.043TrpArg: 1.043 ± 0.035	0.96TrpSer: 0.96 ± 0.04	0.898TrpThr: 0.898 ± 0.034	1.072TrpVal: 1.072 ± 0.036	0.321TrpTrp: 0.321 ± 0.018	0.274TrpTyr: 0.274 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.273TyrAla: 2.273 ± 0.053	0.103TyrCys: 0.103 ± 0.012	1.105TyrAsp: 1.105 ± 0.033	0.943TyrGlu: 0.943 ± 0.035	0.729TyrPhe: 0.729 ± 0.028	1.742TyrGly: 1.742 ± 0.044	0.27TyrHis: 0.27 ± 0.017	0.685TyrIle: 0.685 ± 0.028	0.353TyrLys: 0.353 ± 0.019	2.239TyrLeu: 2.239 ± 0.055	0.25TyrMet: 0.25 ± 0.015	0.565TyrAsn: 0.565 ± 0.025	1.189TyrPro: 1.189 ± 0.039	0.627TyrGln: 0.627 ± 0.023	1.682TyrArg: 1.682 ± 0.045	1.203TyrSer: 1.203 ± 0.036	1.334TyrThr: 1.334 ± 0.042	1.583TyrVal: 1.583 ± 0.041	0.326TyrTrp: 0.326 ± 0.02	0.438TyrTyr: 0.438 ± 0.021	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3070 proteins (1024074 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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