Amino acid dipepetide frequency for Massilia arenosa

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
18.448AlaAla: 18.448 ± 0.194
1.201AlaCys: 1.201 ± 0.033
6.688AlaAsp: 6.688 ± 0.079
6.491AlaGlu: 6.491 ± 0.075
3.981AlaPhe: 3.981 ± 0.057
10.342AlaGly: 10.342 ± 0.107
2.774AlaHis: 2.774 ± 0.052
5.447AlaIle: 5.447 ± 0.057
4.018AlaLys: 4.018 ± 0.06
13.952AlaLeu: 13.952 ± 0.131
3.255AlaMet: 3.255 ± 0.047
3.362AlaAsn: 3.362 ± 0.054
6.327AlaPro: 6.327 ± 0.079
5.663AlaGln: 5.663 ± 0.071
8.898AlaArg: 8.898 ± 0.091
6.545AlaSer: 6.545 ± 0.077
6.449AlaThr: 6.449 ± 0.078
8.735AlaVal: 8.735 ± 0.08
1.775AlaTrp: 1.775 ± 0.044
2.757AlaTyr: 2.757 ± 0.048
0.0AlaXaa: 0.0 ± 0.0
Cys
1.204CysAla: 1.204 ± 0.03
0.123CysCys: 0.123 ± 0.01
0.466CysAsp: 0.466 ± 0.016
0.449CysGlu: 0.449 ± 0.017
0.282CysPhe: 0.282 ± 0.015
0.89CysGly: 0.89 ± 0.028
0.25CysHis: 0.25 ± 0.014
0.385CysIle: 0.385 ± 0.016
0.229CysLys: 0.229 ± 0.012
0.778CysLeu: 0.778 ± 0.022
0.162CysMet: 0.162 ± 0.01
0.221CysAsn: 0.221 ± 0.011
0.401CysPro: 0.401 ± 0.016
0.237CysGln: 0.237 ± 0.012
0.521CysArg: 0.521 ± 0.022
0.452CysSer: 0.452 ± 0.02
0.457CysThr: 0.457 ± 0.017
0.668CysVal: 0.668 ± 0.021
0.127CysTrp: 0.127 ± 0.009
0.201CysTyr: 0.201 ± 0.012
0.0CysXaa: 0.0 ± 0.0
Asp
6.964AspAla: 6.964 ± 0.08
0.419AspCys: 0.419 ± 0.019
2.87AspAsp: 2.87 ± 0.049
3.287AspGlu: 3.287 ± 0.052
2.126AspPhe: 2.126 ± 0.038
4.98AspGly: 4.98 ± 0.092
1.171AspHis: 1.171 ± 0.03
2.64AspIle: 2.64 ± 0.045
1.992AspLys: 1.992 ± 0.039
5.308AspLeu: 5.308 ± 0.069
1.307AspMet: 1.307 ± 0.029
1.443AspAsn: 1.443 ± 0.03
3.071AspPro: 3.071 ± 0.049
1.965AspGln: 1.965 ± 0.034
3.371AspArg: 3.371 ± 0.044
2.45AspSer: 2.45 ± 0.04
2.792AspThr: 2.792 ± 0.051
4.096AspVal: 4.096 ± 0.054
0.93AspTrp: 0.93 ± 0.027
1.635AspTyr: 1.635 ± 0.039
0.0AspXaa: 0.0 ± 0.0
Glu
6.161GluAla: 6.161 ± 0.077
0.382GluCys: 0.382 ± 0.016
2.35GluAsp: 2.35 ± 0.043
2.825GluGlu: 2.825 ± 0.056
1.832GluPhe: 1.832 ± 0.035
3.621GluGly: 3.621 ± 0.053
1.402GluHis: 1.402 ± 0.03
2.608GluIle: 2.608 ± 0.05
2.064GluLys: 2.064 ± 0.045
5.953GluLeu: 5.953 ± 0.074
1.32GluMet: 1.32 ± 0.032
1.424GluAsn: 1.424 ± 0.035
2.365GluPro: 2.365 ± 0.042
2.794GluGln: 2.794 ± 0.049
4.499GluArg: 4.499 ± 0.067
2.343GluSer: 2.343 ± 0.041
2.667GluThr: 2.667 ± 0.044
3.79GluVal: 3.79 ± 0.057
0.754GluTrp: 0.754 ± 0.023
1.291GluTyr: 1.291 ± 0.029
0.0GluXaa: 0.0 ± 0.0
Phe
4.308PheAla: 4.308 ± 0.056
0.366PheCys: 0.366 ± 0.016
2.504PheAsp: 2.504 ± 0.04
1.922PheGlu: 1.922 ± 0.039
1.355PhePhe: 1.355 ± 0.033
3.431PheGly: 3.431 ± 0.045
0.721PheHis: 0.721 ± 0.022
1.603PheIle: 1.603 ± 0.032
1.255PheLys: 1.255 ± 0.033
2.997PheLeu: 2.997 ± 0.046
0.806PheMet: 0.806 ± 0.024
1.315PheAsn: 1.315 ± 0.034
1.487PhePro: 1.487 ± 0.033
1.076PheGln: 1.076 ± 0.028
1.982PheArg: 1.982 ± 0.039
2.128PheSer: 2.128 ± 0.035
2.2PheThr: 2.2 ± 0.041
2.682PheVal: 2.682 ± 0.045
0.482PheTrp: 0.482 ± 0.02
0.995PheTyr: 0.995 ± 0.028
0.0PheXaa: 0.0 ± 0.0
Gly
9.273GlyAla: 9.273 ± 0.088
0.806GlyCys: 0.806 ± 0.025
4.052GlyAsp: 4.052 ± 0.064
4.076GlyGlu: 4.076 ± 0.053
3.187GlyPhe: 3.187 ± 0.05
6.88GlyGly: 6.88 ± 0.104
1.988GlyHis: 1.988 ± 0.038
3.954GlyIle: 3.954 ± 0.048
3.418GlyLys: 3.418 ± 0.053
8.061GlyLeu: 8.061 ± 0.074
2.379GlyMet: 2.379 ± 0.04
2.255GlyAsn: 2.255 ± 0.056
3.061GlyPro: 3.061 ± 0.045
3.364GlyGln: 3.364 ± 0.045
5.072GlyArg: 5.072 ± 0.059
4.725GlySer: 4.725 ± 0.078
5.001GlyThr: 5.001 ± 0.097
6.218GlyVal: 6.218 ± 0.068
1.325GlyTrp: 1.325 ± 0.033
2.532GlyTyr: 2.532 ± 0.042
0.0GlyXaa: 0.0 ± 0.0
His
2.981HisAla: 2.981 ± 0.051
0.259HisCys: 0.259 ± 0.014
1.251HisAsp: 1.251 ± 0.027
1.229HisGlu: 1.229 ± 0.027
0.97HisPhe: 0.97 ± 0.027
2.166HisGly: 2.166 ± 0.041
0.643HisHis: 0.643 ± 0.024
1.044HisIle: 1.044 ± 0.028
0.634HisLys: 0.634 ± 0.022
2.251HisLeu: 2.251 ± 0.045
0.546HisMet: 0.546 ± 0.019
0.558HisAsn: 0.558 ± 0.021
1.394HisPro: 1.394 ± 0.028
0.747HisGln: 0.747 ± 0.022
1.348HisArg: 1.348 ± 0.03
1.071HisSer: 1.071 ± 0.028
1.198HisThr: 1.198 ± 0.03
1.643HisVal: 1.643 ± 0.029
0.348HisTrp: 0.348 ± 0.017
0.697HisTyr: 0.697 ± 0.026
0.0HisXaa: 0.0 ± 0.0
Ile
6.136IleAla: 6.136 ± 0.074
0.366IleCys: 0.366 ± 0.015
3.205IleAsp: 3.205 ± 0.042
3.047IleGlu: 3.047 ± 0.052
1.307IlePhe: 1.307 ± 0.032
4.291IleGly: 4.291 ± 0.059
0.89IleHis: 0.89 ± 0.028
1.787IleIle: 1.787 ± 0.04
1.632IleLys: 1.632 ± 0.037
3.765IleLeu: 3.765 ± 0.058
0.916IleMet: 0.916 ± 0.023
1.506IleAsn: 1.506 ± 0.033
2.139IlePro: 2.139 ± 0.04
1.184IleGln: 1.184 ± 0.029
2.636IleArg: 2.636 ± 0.037
2.399IleSer: 2.399 ± 0.041
2.558IleThr: 2.558 ± 0.049
3.721IleVal: 3.721 ± 0.047
0.441IleTrp: 0.441 ± 0.016
1.061IleTyr: 1.061 ± 0.028
0.0IleXaa: 0.0 ± 0.0
Lys
4.2LysAla: 4.2 ± 0.063
0.174LysCys: 0.174 ± 0.016
1.945LysAsp: 1.945 ± 0.035
1.733LysGlu: 1.733 ± 0.04
1.078LysPhe: 1.078 ± 0.031
2.377LysGly: 2.377 ± 0.048
0.737LysHis: 0.737 ± 0.024
1.643LysIle: 1.643 ± 0.036
1.508LysLys: 1.508 ± 0.042
3.822LysLeu: 3.822 ± 0.052
0.968LysMet: 0.968 ± 0.032
1.117LysAsn: 1.117 ± 0.03
2.211LysPro: 2.211 ± 0.046
1.362LysGln: 1.362 ± 0.036
2.276LysArg: 2.276 ± 0.045
1.801LysSer: 1.801 ± 0.04
1.951LysThr: 1.951 ± 0.042
2.65LysVal: 2.65 ± 0.045
0.378LysTrp: 0.378 ± 0.017
0.827LysTyr: 0.827 ± 0.026
0.0LysXaa: 0.0 ± 0.0
Leu
14.632LeuAla: 14.632 ± 0.128
0.945LeuCys: 0.945 ± 0.026
6.134LeuAsp: 6.134 ± 0.075
5.07LeuGlu: 5.07 ± 0.073
3.436LeuPhe: 3.436 ± 0.056
7.877LeuGly: 7.877 ± 0.064
2.348LeuHis: 2.348 ± 0.044
4.083LeuIle: 4.083 ± 0.058
3.709LeuLys: 3.709 ± 0.057
10.312LeuLeu: 10.312 ± 0.119
2.304LeuMet: 2.304 ± 0.038
3.021LeuAsn: 3.021 ± 0.048
5.789LeuPro: 5.789 ± 0.071
3.806LeuGln: 3.806 ± 0.048
7.46LeuArg: 7.46 ± 0.088
5.612LeuSer: 5.612 ± 0.067
5.692LeuThr: 5.692 ± 0.067
7.407LeuVal: 7.407 ± 0.081
1.098LeuTrp: 1.098 ± 0.033
2.279LeuTyr: 2.279 ± 0.047
0.0LeuXaa: 0.0 ± 0.0
Met
2.863MetAla: 2.863 ± 0.045
0.189MetCys: 0.189 ± 0.012
1.222MetAsp: 1.222 ± 0.032
1.168MetGlu: 1.168 ± 0.025
0.782MetPhe: 0.782 ± 0.024
1.697MetGly: 1.697 ± 0.035
0.59MetHis: 0.59 ± 0.021
1.043MetIle: 1.043 ± 0.029
1.133MetLys: 1.133 ± 0.034
2.684MetLeu: 2.684 ± 0.048
0.607MetMet: 0.607 ± 0.024
0.937MetAsn: 0.937 ± 0.028
1.457MetPro: 1.457 ± 0.033
1.111MetGln: 1.111 ± 0.029
1.739MetArg: 1.739 ± 0.035
1.559MetSer: 1.559 ± 0.031
1.618MetThr: 1.618 ± 0.036
1.635MetVal: 1.635 ± 0.035
0.252MetTrp: 0.252 ± 0.012
0.532MetTyr: 0.532 ± 0.02
0.0MetXaa: 0.0 ± 0.0
Asn
3.508AsnAla: 3.508 ± 0.053
0.271AsnCys: 0.271 ± 0.015
1.546AsnAsp: 1.546 ± 0.041
1.409AsnGlu: 1.409 ± 0.03
1.1AsnPhe: 1.1 ± 0.03
2.775AsnGly: 2.775 ± 0.054
0.591AsnHis: 0.591 ± 0.021
1.408AsnIle: 1.408 ± 0.035
0.947AsnLys: 0.947 ± 0.025
2.876AsnLeu: 2.876 ± 0.046
0.659AsnMet: 0.659 ± 0.021
0.932AsnAsn: 0.932 ± 0.032
1.892AsnPro: 1.892 ± 0.036
1.009AsnGln: 1.009 ± 0.026
1.793AsnArg: 1.793 ± 0.04
1.411AsnSer: 1.411 ± 0.032
1.57AsnThr: 1.57 ± 0.034
2.363AsnVal: 2.363 ± 0.041
0.436AsnTrp: 0.436 ± 0.019
0.852AsnTyr: 0.852 ± 0.023
0.0AsnXaa: 0.0 ± 0.0
Pro
7.005ProAla: 7.005 ± 0.094
0.321ProCys: 0.321 ± 0.017
3.295ProAsp: 3.295 ± 0.05
3.177ProGlu: 3.177 ± 0.046
1.842ProPhe: 1.842 ± 0.037
4.438ProGly: 4.438 ± 0.06
1.186ProHis: 1.186 ± 0.03
1.829ProIle: 1.829 ± 0.034
1.572ProLys: 1.572 ± 0.033
5.07ProLeu: 5.07 ± 0.053
1.184ProMet: 1.184 ± 0.024
1.474ProAsn: 1.474 ± 0.035
2.675ProPro: 2.675 ± 0.06
2.133ProGln: 2.133 ± 0.038
2.903ProArg: 2.903 ± 0.048
2.664ProSer: 2.664 ± 0.046
2.438ProThr: 2.438 ± 0.037
4.252ProVal: 4.252 ± 0.055
0.644ProTrp: 0.644 ± 0.023
1.199ProTyr: 1.199 ± 0.028
0.0ProXaa: 0.0 ± 0.0
Gln
5.053GlnAla: 5.053 ± 0.065
0.28GlnCys: 0.28 ± 0.014
1.831GlnAsp: 1.831 ± 0.034
1.721GlnGlu: 1.721 ± 0.04
1.382GlnPhe: 1.382 ± 0.026
2.828GlnGly: 2.828 ± 0.046
0.981GlnHis: 0.981 ± 0.025
1.747GlnIle: 1.747 ± 0.04
1.271GlnLys: 1.271 ± 0.032
4.38GlnLeu: 4.38 ± 0.055
1.084GlnMet: 1.084 ± 0.026
1.068GlnAsn: 1.068 ± 0.03
2.276GlnPro: 2.276 ± 0.037
2.043GlnGln: 2.043 ± 0.044
3.196GlnArg: 3.196 ± 0.047
1.924GlnSer: 1.924 ± 0.039
1.871GlnThr: 1.871 ± 0.039
3.063GlnVal: 3.063 ± 0.052
0.519GlnTrp: 0.519 ± 0.018
0.968GlnTyr: 0.968 ± 0.024
0.0GlnXaa: 0.0 ± 0.0
Arg
8.062ArgAla: 8.062 ± 0.088
0.513ArgCys: 0.513 ± 0.021
3.668ArgAsp: 3.668 ± 0.053
3.876ArgGlu: 3.876 ± 0.054
2.674ArgPhe: 2.674 ± 0.048
4.451ArgGly: 4.451 ± 0.058
1.795ArgHis: 1.795 ± 0.037
3.538ArgIle: 3.538 ± 0.052
2.29ArgLys: 2.29 ± 0.043
6.958ArgLeu: 6.958 ± 0.084
2.016ArgMet: 2.016 ± 0.033
1.966ArgAsn: 1.966 ± 0.038
2.95ArgPro: 2.95 ± 0.042
2.801ArgGln: 2.801 ± 0.048
4.674ArgArg: 4.674 ± 0.07
3.322ArgSer: 3.322 ± 0.048
3.626ArgThr: 3.626 ± 0.045
4.797ArgVal: 4.797 ± 0.065
1.037ArgTrp: 1.037 ± 0.028
2.069ArgTyr: 2.069 ± 0.041
0.0ArgXaa: 0.0 ± 0.0
Ser
6.667SerAla: 6.667 ± 0.07
0.423SerCys: 0.423 ± 0.018
2.641SerAsp: 2.641 ± 0.042
2.449SerGlu: 2.449 ± 0.046
2.121SerPhe: 2.121 ± 0.045
5.198SerGly: 5.198 ± 0.077
1.178SerHis: 1.178 ± 0.026
2.475SerIle: 2.475 ± 0.036
1.696SerLys: 1.696 ± 0.034
5.188SerLeu: 5.188 ± 0.059
1.355SerMet: 1.355 ± 0.031
1.544SerAsn: 1.544 ± 0.03
2.547SerPro: 2.547 ± 0.045
1.81SerGln: 1.81 ± 0.039
3.026SerArg: 3.026 ± 0.044
3.075SerSer: 3.075 ± 0.055
3.107SerThr: 3.107 ± 0.048
3.97SerVal: 3.97 ± 0.062
0.756SerTrp: 0.756 ± 0.025
1.468SerTyr: 1.468 ± 0.033
0.0SerXaa: 0.0 ± 0.0
Thr
6.576ThrAla: 6.576 ± 0.089
0.396ThrCys: 0.396 ± 0.019
2.857ThrAsp: 2.857 ± 0.05
2.522ThrGlu: 2.522 ± 0.044
1.953ThrPhe: 1.953 ± 0.04
5.127ThrGly: 5.127 ± 0.075
1.179ThrHis: 1.179 ± 0.032
2.709ThrIle: 2.709 ± 0.045
1.449ThrLys: 1.449 ± 0.039
6.22ThrLeu: 6.22 ± 0.075
1.263ThrMet: 1.263 ± 0.028
1.492ThrAsn: 1.492 ± 0.035
3.336ThrPro: 3.336 ± 0.043
1.884ThrGln: 1.884 ± 0.036
3.458ThrArg: 3.458 ± 0.047
2.921ThrSer: 2.921 ± 0.054
3.032ThrThr: 3.032 ± 0.058
4.663ThrVal: 4.663 ± 0.067
0.834ThrTrp: 0.834 ± 0.026
1.323ThrTyr: 1.323 ± 0.034
0.0ThrXaa: 0.0 ± 0.0
Val
8.972ValAla: 8.972 ± 0.085
0.665ValCys: 0.665 ± 0.02
4.116ValAsp: 4.116 ± 0.055
4.118ValGlu: 4.118 ± 0.058
2.619ValPhe: 2.619 ± 0.042
5.191ValGly: 5.191 ± 0.059
1.61ValHis: 1.61 ± 0.035
3.448ValIle: 3.448 ± 0.046
2.602ValLys: 2.602 ± 0.045
8.074ValLeu: 8.074 ± 0.091
1.762ValMet: 1.762 ± 0.035
2.437ValAsn: 2.437 ± 0.044
4.046ValPro: 4.046 ± 0.057
2.804ValGln: 2.804 ± 0.048
5.243ValArg: 5.243 ± 0.061
4.086ValSer: 4.086 ± 0.047
4.59ValThr: 4.59 ± 0.064
5.867ValVal: 5.867 ± 0.073
0.919ValTrp: 0.919 ± 0.024
1.778ValTyr: 1.778 ± 0.031
0.0ValXaa: 0.0 ± 0.0
Trp
1.137TrpAla: 1.137 ± 0.03
0.153TrpCys: 0.153 ± 0.01
0.712TrpAsp: 0.712 ± 0.022
0.565TrpGlu: 0.565 ± 0.019
0.567TrpPhe: 0.567 ± 0.019
0.864TrpGly: 0.864 ± 0.027
0.354TrpHis: 0.354 ± 0.015
0.64TrpIle: 0.64 ± 0.023
0.495TrpLys: 0.495 ± 0.019
1.754TrpLeu: 1.754 ± 0.041
0.426TrpMet: 0.426 ± 0.019
0.488TrpAsn: 0.488 ± 0.019
0.609TrpPro: 0.609 ± 0.025
0.666TrpGln: 0.666 ± 0.021
1.1TrpArg: 1.1 ± 0.029
0.801TrpSer: 0.801 ± 0.026
0.859TrpThr: 0.859 ± 0.026
0.911TrpVal: 0.911 ± 0.027
0.241TrpTrp: 0.241 ± 0.014
0.376TrpTyr: 0.376 ± 0.019
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.957TyrAla: 2.957 ± 0.045
0.25TyrCys: 0.25 ± 0.013
1.461TyrAsp: 1.461 ± 0.035
1.312TyrGlu: 1.312 ± 0.031
1.021TyrPhe: 1.021 ± 0.028
2.201TyrGly: 2.201 ± 0.043
0.589TyrHis: 0.589 ± 0.02
0.957TyrIle: 0.957 ± 0.027
0.843TyrLys: 0.843 ± 0.025
2.611TyrLeu: 2.611 ± 0.044
0.499TyrMet: 0.499 ± 0.017
0.789TyrAsn: 0.789 ± 0.024
1.268TyrPro: 1.268 ± 0.028
1.025TyrGln: 1.025 ± 0.029
1.888TyrArg: 1.888 ± 0.034
1.41TyrSer: 1.41 ± 0.031
1.521TyrThr: 1.521 ± 0.035
1.815TyrVal: 1.815 ± 0.033
0.421TyrTrp: 0.421 ± 0.018
0.714TyrTyr: 0.714 ± 0.026
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4573 proteins (1509730 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski