Amino acid dipepetide frequency for Gentian ovary ringspot virus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
2.876AlaAla: 2.876 ± 0.733
1.438AlaCys: 1.438 ± 0.582
3.235AlaAsp: 3.235 ± 0.561
5.392AlaGlu: 5.392 ± 1.57
2.157AlaPhe: 2.157 ± 0.361
3.595AlaGly: 3.595 ± 1.733
0.0AlaHis: 0.0 ± 0.0
3.235AlaIle: 3.235 ± 1.739
3.235AlaLys: 3.235 ± 1.391
4.673AlaLeu: 4.673 ± 2.117
2.516AlaMet: 2.516 ± 0.622
1.078AlaAsn: 1.078 ± 0.797
1.438AlaPro: 1.438 ± 1.294
2.157AlaGln: 2.157 ± 0.549
3.235AlaArg: 3.235 ± 0.791
2.516AlaSer: 2.516 ± 0.689
3.954AlaThr: 3.954 ± 0.968
6.47AlaVal: 6.47 ± 1.644
1.078AlaTrp: 1.078 ± 0.703
1.438AlaTyr: 1.438 ± 0.683
0.0AlaXaa: 0.0 ± 0.0
Cys
1.078CysAla: 1.078 ± 0.478
2.157CysCys: 2.157 ± 0.686
1.438CysAsp: 1.438 ± 0.582
1.438CysGlu: 1.438 ± 0.582
0.719CysPhe: 0.719 ± 0.282
1.797CysGly: 1.797 ± 0.378
0.0CysHis: 0.0 ± 0.0
0.719CysIle: 0.719 ± 0.476
1.438CysLys: 1.438 ± 0.922
3.954CysLeu: 3.954 ± 0.724
0.359CysMet: 0.359 ± 0.443
0.359CysAsn: 0.359 ± 0.228
1.078CysPro: 1.078 ± 0.478
1.078CysGln: 1.078 ± 0.396
0.359CysArg: 0.359 ± 0.228
3.235CysSer: 3.235 ± 1.376
0.719CysThr: 0.719 ± 0.583
2.157CysVal: 2.157 ± 1.015
0.0CysTrp: 0.0 ± 0.0
1.078CysTyr: 1.078 ± 0.716
0.0CysXaa: 0.0 ± 0.0
Asp
4.313AspAla: 4.313 ± 0.954
2.157AspCys: 2.157 ± 0.982
5.032AspAsp: 5.032 ± 0.942
3.595AspGlu: 3.595 ± 0.738
1.438AspPhe: 1.438 ± 0.922
3.235AspGly: 3.235 ± 0.837
0.719AspHis: 0.719 ± 0.338
6.111AspIle: 6.111 ± 1.448
2.876AspLys: 2.876 ± 0.873
9.346AspLeu: 9.346 ± 1.651
1.438AspMet: 1.438 ± 0.675
3.954AspAsn: 3.954 ± 1.095
1.438AspPro: 1.438 ± 0.675
1.797AspGln: 1.797 ± 1.028
2.157AspArg: 2.157 ± 0.536
6.83AspSer: 6.83 ± 1.905
3.954AspThr: 3.954 ± 1.094
5.032AspVal: 5.032 ± 1.109
0.359AspTrp: 0.359 ± 0.542
2.876AspTyr: 2.876 ± 1.077
0.0AspXaa: 0.0 ± 0.0
Glu
3.954GluAla: 3.954 ± 0.438
1.078GluCys: 1.078 ± 0.505
2.516GluAsp: 2.516 ± 0.75
4.313GluGlu: 4.313 ± 1.473
2.876GluPhe: 2.876 ± 1.1
3.235GluGly: 3.235 ± 1.169
1.078GluHis: 1.078 ± 0.547
4.673GluIle: 4.673 ± 1.564
6.83GluLys: 6.83 ± 1.234
5.032GluLeu: 5.032 ± 1.085
0.719GluMet: 0.719 ± 0.338
1.797GluAsn: 1.797 ± 0.791
1.078GluPro: 1.078 ± 0.396
1.078GluGln: 1.078 ± 0.393
6.111GluArg: 6.111 ± 1.071
3.954GluSer: 3.954 ± 0.487
2.157GluThr: 2.157 ± 0.846
3.595GluVal: 3.595 ± 1.137
1.438GluTrp: 1.438 ± 0.53
3.954GluTyr: 3.954 ± 1.121
0.0GluXaa: 0.0 ± 0.0
Phe
1.797PheAla: 1.797 ± 1.152
1.797PheCys: 1.797 ± 0.584
1.797PheAsp: 1.797 ± 0.791
2.876PheGlu: 2.876 ± 1.12
1.797PhePhe: 1.797 ± 1.032
3.235PheGly: 3.235 ± 1.439
0.719PheHis: 0.719 ± 0.457
2.157PheIle: 2.157 ± 0.957
3.954PheLys: 3.954 ± 0.658
4.313PheLeu: 4.313 ± 0.675
0.719PheMet: 0.719 ± 0.338
2.876PheAsn: 2.876 ± 0.545
2.157PhePro: 2.157 ± 0.897
2.157PheGln: 2.157 ± 1.26
1.797PheArg: 1.797 ± 0.392
5.392PheSer: 5.392 ± 1.374
2.157PheThr: 2.157 ± 0.686
2.516PheVal: 2.516 ± 0.908
0.719PheTrp: 0.719 ± 0.457
0.719PheTyr: 0.719 ± 0.631
0.0PheXaa: 0.0 ± 0.0
Gly
1.438GlyAla: 1.438 ± 0.61
2.157GlyCys: 2.157 ± 0.836
5.032GlyAsp: 5.032 ± 1.321
3.235GlyGlu: 3.235 ± 0.816
2.157GlyPhe: 2.157 ± 0.569
5.032GlyGly: 5.032 ± 1.186
0.719GlyHis: 0.719 ± 0.338
3.235GlyIle: 3.235 ± 0.994
7.189GlyLys: 7.189 ± 2.006
5.392GlyLeu: 5.392 ± 1.154
1.438GlyMet: 1.438 ± 0.628
3.235GlyAsn: 3.235 ± 1.007
0.719GlyPro: 0.719 ± 0.462
1.438GlyGln: 1.438 ± 0.564
2.876GlyArg: 2.876 ± 1.051
3.235GlySer: 3.235 ± 2.271
4.313GlyThr: 4.313 ± 1.231
2.516GlyVal: 2.516 ± 1.053
0.0GlyTrp: 0.0 ± 0.0
3.235GlyTyr: 3.235 ± 0.813
0.0GlyXaa: 0.0 ± 0.0
His
0.359HisAla: 0.359 ± 0.489
0.359HisCys: 0.359 ± 0.228
1.078HisAsp: 1.078 ± 0.563
1.078HisGlu: 1.078 ± 0.445
1.078HisPhe: 1.078 ± 0.703
1.078HisGly: 1.078 ± 0.563
0.359HisHis: 0.359 ± 0.501
0.719HisIle: 0.719 ± 0.338
1.438HisLys: 1.438 ± 0.718
0.0HisLeu: 0.0 ± 0.0
0.719HisMet: 0.719 ± 0.457
0.359HisAsn: 0.359 ± 0.326
1.078HisPro: 1.078 ± 0.823
1.078HisGln: 1.078 ± 0.565
0.0HisArg: 0.0 ± 0.0
1.797HisSer: 1.797 ± 1.142
0.719HisThr: 0.719 ± 0.282
1.078HisVal: 1.078 ± 0.51
0.0HisTrp: 0.0 ± 0.0
1.797HisTyr: 1.797 ± 0.683
0.0HisXaa: 0.0 ± 0.0
Ile
2.876IleAla: 2.876 ± 0.748
1.438IleCys: 1.438 ± 0.914
3.235IleAsp: 3.235 ± 0.784
4.673IleGlu: 4.673 ± 1.216
3.954IlePhe: 3.954 ± 1.991
3.235IleGly: 3.235 ± 0.883
2.157IleHis: 2.157 ± 1.115
2.157IleIle: 2.157 ± 1.345
3.595IleLys: 3.595 ± 0.866
3.595IleLeu: 3.595 ± 0.654
0.359IleMet: 0.359 ± 0.501
3.235IleAsn: 3.235 ± 0.743
2.876IlePro: 2.876 ± 1.077
2.157IleGln: 2.157 ± 0.648
3.595IleArg: 3.595 ± 1.355
4.313IleSer: 4.313 ± 1.113
1.078IleThr: 1.078 ± 0.563
3.595IleVal: 3.595 ± 0.934
0.0IleTrp: 0.0 ± 0.0
1.438IleTyr: 1.438 ± 0.693
0.0IleXaa: 0.0 ± 0.0
Lys
4.313LysAla: 4.313 ± 1.283
1.797LysCys: 1.797 ± 0.791
6.47LysAsp: 6.47 ± 1.534
3.954LysGlu: 3.954 ± 0.997
3.954LysPhe: 3.954 ± 1.28
4.313LysGly: 4.313 ± 1.422
0.719LysHis: 0.719 ± 0.583
3.595LysIle: 3.595 ± 0.738
6.111LysLys: 6.111 ± 1.124
8.267LysLeu: 8.267 ± 1.685
1.797LysMet: 1.797 ± 0.645
3.595LysAsn: 3.595 ± 1.342
2.516LysPro: 2.516 ± 0.671
1.797LysGln: 1.797 ± 0.453
6.111LysArg: 6.111 ± 1.08
7.189LysSer: 7.189 ± 2.114
5.032LysThr: 5.032 ± 0.954
5.032LysVal: 5.032 ± 1.341
0.719LysTrp: 0.719 ± 0.282
0.719LysTyr: 0.719 ± 0.338
0.0LysXaa: 0.0 ± 0.0
Leu
3.954LeuAla: 3.954 ± 0.991
1.797LeuCys: 1.797 ± 0.881
5.751LeuAsp: 5.751 ± 1.528
4.673LeuGlu: 4.673 ± 0.656
5.392LeuPhe: 5.392 ± 0.573
3.595LeuGly: 3.595 ± 1.003
1.438LeuHis: 1.438 ± 0.675
6.83LeuIle: 6.83 ± 1.977
6.83LeuLys: 6.83 ± 1.527
10.424LeuLeu: 10.424 ± 2.789
4.313LeuMet: 4.313 ± 1.478
5.392LeuAsn: 5.392 ± 1.61
3.235LeuPro: 3.235 ± 0.569
2.516LeuGln: 2.516 ± 0.863
4.313LeuArg: 4.313 ± 1.295
5.751LeuSer: 5.751 ± 0.92
3.954LeuThr: 3.954 ± 1.283
5.751LeuVal: 5.751 ± 1.358
0.719LeuTrp: 0.719 ± 0.338
2.876LeuTyr: 2.876 ± 0.836
0.0LeuXaa: 0.0 ± 0.0
Met
0.719MetAla: 0.719 ± 0.282
0.359MetCys: 0.359 ± 0.366
3.595MetAsp: 3.595 ± 1.67
1.078MetGlu: 1.078 ± 0.946
0.359MetPhe: 0.359 ± 0.228
1.078MetGly: 1.078 ± 0.445
0.359MetHis: 0.359 ± 0.228
0.719MetIle: 0.719 ± 0.338
3.235MetLys: 3.235 ± 1.049
3.954MetLeu: 3.954 ± 1.217
0.359MetMet: 0.359 ± 0.228
0.719MetAsn: 0.719 ± 0.282
1.078MetPro: 1.078 ± 0.505
0.719MetGln: 0.719 ± 0.457
1.797MetArg: 1.797 ± 0.814
1.797MetSer: 1.797 ± 0.922
2.516MetThr: 2.516 ± 1.057
1.078MetVal: 1.078 ± 0.654
0.0MetTrp: 0.0 ± 0.0
0.719MetTyr: 0.719 ± 0.457
0.0MetXaa: 0.0 ± 0.0
Asn
5.751AsnAla: 5.751 ± 0.663
0.359AsnCys: 0.359 ± 0.326
1.797AsnAsp: 1.797 ± 0.749
3.235AsnGlu: 3.235 ± 0.933
2.876AsnPhe: 2.876 ± 1.719
3.235AsnGly: 3.235 ± 0.837
0.719AsnHis: 0.719 ± 0.282
2.516AsnIle: 2.516 ± 0.912
3.595AsnLys: 3.595 ± 1.128
4.313AsnLeu: 4.313 ± 0.988
2.516AsnMet: 2.516 ± 0.578
3.595AsnAsn: 3.595 ± 1.575
1.078AsnPro: 1.078 ± 0.302
3.235AsnGln: 3.235 ± 1.051
1.078AsnArg: 1.078 ± 0.661
2.876AsnSer: 2.876 ± 0.456
1.438AsnThr: 1.438 ± 0.31
2.876AsnVal: 2.876 ± 1.111
0.719AsnTrp: 0.719 ± 0.462
2.157AsnTyr: 2.157 ± 1.319
0.0AsnXaa: 0.0 ± 0.0
Pro
2.516ProAla: 2.516 ± 1.177
0.719ProCys: 0.719 ± 0.542
1.797ProAsp: 1.797 ± 1.136
3.235ProGlu: 3.235 ± 0.735
0.719ProPhe: 0.719 ± 0.472
2.876ProGly: 2.876 ± 0.56
0.0ProHis: 0.0 ± 0.0
0.359ProIle: 0.359 ± 0.228
5.392ProLys: 5.392 ± 0.915
2.516ProLeu: 2.516 ± 0.694
0.359ProMet: 0.359 ± 0.366
1.797ProAsn: 1.797 ± 0.81
0.359ProPro: 0.359 ± 0.501
1.438ProGln: 1.438 ± 0.482
1.797ProArg: 1.797 ± 0.959
2.876ProSer: 2.876 ± 0.551
2.516ProThr: 2.516 ± 0.918
2.876ProVal: 2.876 ± 0.781
0.359ProTrp: 0.359 ± 0.366
0.719ProTyr: 0.719 ± 0.457
0.0ProXaa: 0.0 ± 0.0
Gln
1.438GlnAla: 1.438 ± 0.671
0.719GlnCys: 0.719 ± 0.282
2.157GlnAsp: 2.157 ± 1.351
2.516GlnGlu: 2.516 ± 0.453
0.719GlnPhe: 0.719 ± 0.433
2.516GlnGly: 2.516 ± 0.861
0.359GlnHis: 0.359 ± 0.366
1.797GlnIle: 1.797 ± 0.415
2.876GlnLys: 2.876 ± 0.604
2.157GlnLeu: 2.157 ± 0.792
0.719GlnMet: 0.719 ± 0.457
1.797GlnAsn: 1.797 ± 0.518
0.359GlnPro: 0.359 ± 0.228
1.438GlnGln: 1.438 ± 0.461
1.438GlnArg: 1.438 ± 0.97
2.157GlnSer: 2.157 ± 0.584
3.595GlnThr: 3.595 ± 0.422
2.516GlnVal: 2.516 ± 0.909
0.359GlnTrp: 0.359 ± 0.366
1.078GlnTyr: 1.078 ± 0.59
0.0GlnXaa: 0.0 ± 0.0
Arg
1.078ArgAla: 1.078 ± 0.646
1.797ArgCys: 1.797 ± 0.932
5.032ArgAsp: 5.032 ± 1.792
2.516ArgGlu: 2.516 ± 0.676
3.595ArgPhe: 3.595 ± 0.604
2.157ArgGly: 2.157 ± 1.371
1.078ArgHis: 1.078 ± 0.393
3.235ArgIle: 3.235 ± 1.233
6.111ArgLys: 6.111 ± 1.024
4.313ArgLeu: 4.313 ± 1.576
1.438ArgMet: 1.438 ± 1.079
2.516ArgAsn: 2.516 ± 1.38
2.157ArgPro: 2.157 ± 0.896
1.078ArgGln: 1.078 ± 1.201
3.235ArgArg: 3.235 ± 1.717
2.516ArgSer: 2.516 ± 1.229
4.313ArgThr: 4.313 ± 0.549
4.313ArgVal: 4.313 ± 0.681
0.719ArgTrp: 0.719 ± 0.733
1.797ArgTyr: 1.797 ± 0.824
0.0ArgXaa: 0.0 ± 0.0
Ser
5.751SerAla: 5.751 ± 1.597
1.438SerCys: 1.438 ± 1.154
6.83SerAsp: 6.83 ± 0.661
4.313SerGlu: 4.313 ± 1.361
3.235SerPhe: 3.235 ± 1.176
4.313SerGly: 4.313 ± 1.213
0.719SerHis: 0.719 ± 0.282
3.595SerIle: 3.595 ± 1.005
5.032SerLys: 5.032 ± 0.938
5.032SerLeu: 5.032 ± 1.06
1.438SerMet: 1.438 ± 0.622
3.235SerAsn: 3.235 ± 0.913
2.876SerPro: 2.876 ± 0.551
1.797SerGln: 1.797 ± 1.279
3.954SerArg: 3.954 ± 1.515
5.751SerSer: 5.751 ± 1.346
3.954SerThr: 3.954 ± 1.245
6.83SerVal: 6.83 ± 1.378
0.359SerTrp: 0.359 ± 0.228
2.876SerTyr: 2.876 ± 0.872
0.0SerXaa: 0.0 ± 0.0
Thr
4.313ThrAla: 4.313 ± 1.158
1.438ThrCys: 1.438 ± 1.124
2.516ThrAsp: 2.516 ± 0.859
2.157ThrGlu: 2.157 ± 0.569
2.876ThrPhe: 2.876 ± 1.149
3.595ThrGly: 3.595 ± 0.915
2.157ThrHis: 2.157 ± 1.106
1.797ThrIle: 1.797 ± 0.455
3.595ThrLys: 3.595 ± 1.297
3.595ThrLeu: 3.595 ± 0.666
2.157ThrMet: 2.157 ± 0.968
2.876ThrAsn: 2.876 ± 0.819
2.157ThrPro: 2.157 ± 0.584
2.876ThrGln: 2.876 ± 1.037
3.595ThrArg: 3.595 ± 0.91
3.954ThrSer: 3.954 ± 1.122
3.954ThrThr: 3.954 ± 1.033
5.032ThrVal: 5.032 ± 0.954
0.719ThrTrp: 0.719 ± 0.338
2.516ThrTyr: 2.516 ± 0.894
0.0ThrXaa: 0.0 ± 0.0
Val
4.313ValAla: 4.313 ± 1.128
0.719ValCys: 0.719 ± 0.433
5.032ValAsp: 5.032 ± 0.665
5.032ValGlu: 5.032 ± 1.837
2.516ValPhe: 2.516 ± 0.763
4.673ValGly: 4.673 ± 1.172
1.438ValHis: 1.438 ± 0.662
3.954ValIle: 3.954 ± 0.998
2.876ValLys: 2.876 ± 1.348
4.313ValLeu: 4.313 ± 0.691
1.438ValMet: 1.438 ± 0.88
3.235ValAsn: 3.235 ± 1.873
4.673ValPro: 4.673 ± 1.078
0.719ValGln: 0.719 ± 0.338
4.673ValArg: 4.673 ± 1.593
6.111ValSer: 6.111 ± 0.795
6.111ValThr: 6.111 ± 1.694
5.032ValVal: 5.032 ± 1.053
1.797ValTrp: 1.797 ± 0.679
1.438ValTyr: 1.438 ± 0.552
0.0ValXaa: 0.0 ± 0.0
Trp
0.0TrpAla: 0.0 ± 0.0
1.078TrpCys: 1.078 ± 0.825
1.078TrpAsp: 1.078 ± 0.396
0.0TrpGlu: 0.0 ± 0.0
0.719TrpPhe: 0.719 ± 0.338
0.0TrpGly: 0.0 ± 0.0
0.359TrpHis: 0.359 ± 0.542
1.438TrpIle: 1.438 ± 0.671
0.719TrpLys: 0.719 ± 0.457
0.719TrpLeu: 0.719 ± 0.282
0.359TrpMet: 0.359 ± 0.351
0.719TrpAsn: 0.719 ± 0.338
0.719TrpPro: 0.719 ± 0.476
0.719TrpGln: 0.719 ± 0.733
0.359TrpArg: 0.359 ± 0.366
0.0TrpSer: 0.0 ± 0.0
0.0TrpThr: 0.0 ± 0.0
0.719TrpVal: 0.719 ± 0.282
0.719TrpTrp: 0.719 ± 0.643
0.719TrpTyr: 0.719 ± 0.457
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.876TyrAla: 2.876 ± 0.782
0.359TyrCys: 0.359 ± 0.228
3.235TyrAsp: 3.235 ± 0.791
2.157TyrGlu: 2.157 ± 0.883
2.516TyrPhe: 2.516 ± 0.568
1.797TyrGly: 1.797 ± 0.814
1.078TyrHis: 1.078 ± 0.563
0.719TyrIle: 0.719 ± 0.282
1.438TyrLys: 1.438 ± 0.31
3.595TyrLeu: 3.595 ± 0.889
0.719TyrMet: 0.719 ± 0.457
3.595TyrAsn: 3.595 ± 1.344
2.157TyrPro: 2.157 ± 0.957
1.438TyrGln: 1.438 ± 0.632
2.516TyrArg: 2.516 ± 0.549
1.078TyrSer: 1.078 ± 0.547
1.438TyrThr: 1.438 ± 0.757
1.078TyrVal: 1.078 ± 0.488
0.359TyrTrp: 0.359 ± 0.366
1.797TyrTyr: 1.797 ± 0.743
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 7 proteins (2783 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski