Amino acid dipepetide frequency for Aliikangiella sp. M105

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
6.158AlaAla: 6.158 ± 0.074
0.797AlaCys: 0.797 ± 0.025
4.28AlaAsp: 4.28 ± 0.054
5.247AlaGlu: 5.247 ± 0.061
3.108AlaPhe: 3.108 ± 0.039
5.31AlaGly: 5.31 ± 0.083
1.371AlaHis: 1.371 ± 0.028
5.512AlaIle: 5.512 ± 0.062
4.561AlaLys: 4.561 ± 0.063
7.416AlaLeu: 7.416 ± 0.078
1.768AlaMet: 1.768 ± 0.035
3.894AlaAsn: 3.894 ± 0.064
2.421AlaPro: 2.421 ± 0.042
3.167AlaGln: 3.167 ± 0.05
3.233AlaArg: 3.233 ± 0.048
5.261AlaSer: 5.261 ± 0.061
4.246AlaThr: 4.246 ± 0.065
4.913AlaVal: 4.913 ± 0.05
0.808AlaTrp: 0.808 ± 0.024
2.279AlaTyr: 2.279 ± 0.037
0.0AlaXaa: 0.0 ± 0.0
Cys
0.626CysAla: 0.626 ± 0.02
0.132CysCys: 0.132 ± 0.009
0.595CysAsp: 0.595 ± 0.018
0.609CysGlu: 0.609 ± 0.021
0.465CysPhe: 0.465 ± 0.013
0.797CysGly: 0.797 ± 0.025
0.303CysHis: 0.303 ± 0.014
0.524CysIle: 0.524 ± 0.016
0.408CysLys: 0.408 ± 0.015
0.921CysLeu: 0.921 ± 0.027
0.175CysMet: 0.175 ± 0.01
0.408CysAsn: 0.408 ± 0.017
0.387CysPro: 0.387 ± 0.017
0.468CysGln: 0.468 ± 0.019
0.488CysArg: 0.488 ± 0.017
0.75CysSer: 0.75 ± 0.023
0.415CysThr: 0.415 ± 0.018
0.602CysVal: 0.602 ± 0.02
0.122CysTrp: 0.122 ± 0.01
0.323CysTyr: 0.323 ± 0.017
0.0CysXaa: 0.0 ± 0.0
Asp
4.002AspAla: 4.002 ± 0.064
0.571AspCys: 0.571 ± 0.023
3.416AspAsp: 3.416 ± 0.087
3.911AspGlu: 3.911 ± 0.055
2.832AspPhe: 2.832 ± 0.039
4.446AspGly: 4.446 ± 0.133
0.954AspHis: 0.954 ± 0.023
4.035AspIle: 4.035 ± 0.046
3.461AspLys: 3.461 ± 0.048
5.196AspLeu: 5.196 ± 0.059
1.091AspMet: 1.091 ± 0.025
3.172AspAsn: 3.172 ± 0.061
2.134AspPro: 2.134 ± 0.041
2.06AspGln: 2.06 ± 0.039
2.202AspArg: 2.202 ± 0.035
4.264AspSer: 4.264 ± 0.069
2.706AspThr: 2.706 ± 0.056
3.35AspVal: 3.35 ± 0.043
0.919AspTrp: 0.919 ± 0.025
2.312AspTyr: 2.312 ± 0.037
0.0AspXaa: 0.0 ± 0.0
Glu
4.511GluAla: 4.511 ± 0.06
0.493GluCys: 0.493 ± 0.019
3.003GluAsp: 3.003 ± 0.05
3.873GluGlu: 3.873 ± 0.074
2.833GluPhe: 2.833 ± 0.041
3.196GluGly: 3.196 ± 0.04
1.354GluHis: 1.354 ± 0.032
4.616GluIle: 4.616 ± 0.058
4.997GluLys: 4.997 ± 0.071
7.104GluLeu: 7.104 ± 0.092
1.5GluMet: 1.5 ± 0.031
3.712GluAsn: 3.712 ± 0.04
1.968GluPro: 1.968 ± 0.029
3.543GluGln: 3.543 ± 0.059
2.971GluArg: 2.971 ± 0.051
4.657GluSer: 4.657 ± 0.054
3.371GluThr: 3.371 ± 0.043
4.089GluVal: 4.089 ± 0.058
0.715GluTrp: 0.715 ± 0.02
1.988GluTyr: 1.988 ± 0.034
0.0GluXaa: 0.0 ± 0.0
Phe
3.211PheAla: 3.211 ± 0.046
0.501PheCys: 0.501 ± 0.016
3.029PheAsp: 3.029 ± 0.038
3.112PheGlu: 3.112 ± 0.05
1.846PhePhe: 1.846 ± 0.04
3.001PheGly: 3.001 ± 0.044
0.838PheHis: 0.838 ± 0.022
2.801PheIle: 2.801 ± 0.041
2.301PheLys: 2.301 ± 0.036
3.623PheLeu: 3.623 ± 0.051
0.833PheMet: 0.833 ± 0.019
2.434PheAsn: 2.434 ± 0.038
1.5PhePro: 1.5 ± 0.031
1.502PheGln: 1.502 ± 0.029
1.754PheArg: 1.754 ± 0.031
3.98PheSer: 3.98 ± 0.055
2.334PheThr: 2.334 ± 0.044
2.885PheVal: 2.885 ± 0.04
0.577PheTrp: 0.577 ± 0.018
1.548PheTyr: 1.548 ± 0.032
0.0PheXaa: 0.0 ± 0.0
Gly
4.741GlyAla: 4.741 ± 0.058
0.775GlyCys: 0.775 ± 0.025
4.053GlyAsp: 4.053 ± 0.088
4.36GlyGlu: 4.36 ± 0.047
3.14GlyPhe: 3.14 ± 0.047
4.82GlyGly: 4.82 ± 0.084
1.36GlyHis: 1.36 ± 0.027
4.449GlyIle: 4.449 ± 0.057
3.917GlyLys: 3.917 ± 0.054
6.211GlyLeu: 6.211 ± 0.072
1.502GlyMet: 1.502 ± 0.038
3.354GlyAsn: 3.354 ± 0.071
1.568GlyPro: 1.568 ± 0.03
2.525GlyGln: 2.525 ± 0.037
2.824GlyArg: 2.824 ± 0.041
4.515GlySer: 4.515 ± 0.081
3.592GlyThr: 3.592 ± 0.07
4.749GlyVal: 4.749 ± 0.06
0.914GlyTrp: 0.914 ± 0.025
2.552GlyTyr: 2.552 ± 0.043
0.0GlyXaa: 0.0 ± 0.0
His
1.287HisAla: 1.287 ± 0.026
0.299HisCys: 0.299 ± 0.013
0.957HisAsp: 0.957 ± 0.025
1.083HisGlu: 1.083 ± 0.022
1.1HisPhe: 1.1 ± 0.025
1.274HisGly: 1.274 ± 0.026
0.621HisHis: 0.621 ± 0.017
1.251HisIle: 1.251 ± 0.028
1.006HisLys: 1.006 ± 0.025
2.035HisLeu: 2.035 ± 0.038
0.399HisMet: 0.399 ± 0.015
0.863HisAsn: 0.863 ± 0.02
0.985HisPro: 0.985 ± 0.024
1.175HisGln: 1.175 ± 0.028
1.046HisArg: 1.046 ± 0.025
1.496HisSer: 1.496 ± 0.03
0.926HisThr: 0.926 ± 0.022
1.05HisVal: 1.05 ± 0.026
0.353HisTrp: 0.353 ± 0.015
0.877HisTyr: 0.877 ± 0.022
0.0HisXaa: 0.0 ± 0.0
Ile
5.659IleAla: 5.659 ± 0.058
0.659IleCys: 0.659 ± 0.019
4.498IleAsp: 4.498 ± 0.056
5.083IleGlu: 5.083 ± 0.064
2.624IlePhe: 2.624 ± 0.039
4.445IleGly: 4.445 ± 0.053
1.225IleHis: 1.225 ± 0.027
4.001IleIle: 4.001 ± 0.053
3.972IleLys: 3.972 ± 0.05
5.549IleLeu: 5.549 ± 0.067
1.076IleMet: 1.076 ± 0.028
3.782IleAsn: 3.782 ± 0.048
2.647IlePro: 2.647 ± 0.037
2.491IleGln: 2.491 ± 0.038
2.912IleArg: 2.912 ± 0.046
5.48IleSer: 5.48 ± 0.064
3.762IleThr: 3.762 ± 0.058
4.152IleVal: 4.152 ± 0.052
0.741IleTrp: 0.741 ± 0.022
2.012IleTyr: 2.012 ± 0.035
0.0IleXaa: 0.0 ± 0.0
Lys
4.401LysAla: 4.401 ± 0.064
0.362LysCys: 0.362 ± 0.016
2.823LysAsp: 2.823 ± 0.041
3.554LysGlu: 3.554 ± 0.06
1.955LysPhe: 1.955 ± 0.037
3.094LysGly: 3.094 ± 0.046
1.227LysHis: 1.227 ± 0.026
4.2LysIle: 4.2 ± 0.055
4.151LysLys: 4.151 ± 0.065
6.202LysLeu: 6.202 ± 0.07
1.333LysMet: 1.333 ± 0.029
3.364LysAsn: 3.364 ± 0.047
2.449LysPro: 2.449 ± 0.041
3.074LysGln: 3.074 ± 0.05
2.798LysArg: 2.798 ± 0.047
4.194LysSer: 4.194 ± 0.063
3.374LysThr: 3.374 ± 0.047
4.1LysVal: 4.1 ± 0.054
0.574LysTrp: 0.574 ± 0.018
1.65LysTyr: 1.65 ± 0.032
0.0LysXaa: 0.0 ± 0.0
Leu
8.24LeuAla: 8.24 ± 0.077
0.873LeuCys: 0.873 ± 0.026
5.506LeuAsp: 5.506 ± 0.064
6.186LeuGlu: 6.186 ± 0.081
4.297LeuPhe: 4.297 ± 0.051
5.881LeuGly: 5.881 ± 0.071
1.709LeuHis: 1.709 ± 0.032
6.564LeuIle: 6.564 ± 0.066
6.189LeuLys: 6.189 ± 0.074
9.686LeuLeu: 9.686 ± 0.112
2.1LeuMet: 2.1 ± 0.039
5.175LeuAsn: 5.175 ± 0.065
4.168LeuPro: 4.168 ± 0.051
3.606LeuGln: 3.606 ± 0.055
3.972LeuArg: 3.972 ± 0.056
8.437LeuSer: 8.437 ± 0.075
5.954LeuThr: 5.954 ± 0.066
6.533LeuVal: 6.533 ± 0.071
1.066LeuTrp: 1.066 ± 0.027
2.583LeuTyr: 2.583 ± 0.042
0.0LeuXaa: 0.0 ± 0.0
Met
1.78MetAla: 1.78 ± 0.035
0.16MetCys: 0.16 ± 0.009
1.028MetAsp: 1.028 ± 0.026
1.149MetGlu: 1.149 ± 0.028
0.73MetPhe: 0.73 ± 0.017
1.268MetGly: 1.268 ± 0.026
0.376MetHis: 0.376 ± 0.015
1.286MetIle: 1.286 ± 0.029
1.41MetLys: 1.41 ± 0.031
2.14MetLeu: 2.14 ± 0.038
0.527MetMet: 0.527 ± 0.017
1.001MetAsn: 1.001 ± 0.027
0.968MetPro: 0.968 ± 0.024
0.919MetGln: 0.919 ± 0.022
0.944MetArg: 0.944 ± 0.025
1.687MetSer: 1.687 ± 0.033
1.225MetThr: 1.225 ± 0.029
1.412MetVal: 1.412 ± 0.032
0.168MetTrp: 0.168 ± 0.009
0.447MetTyr: 0.447 ± 0.013
0.0MetXaa: 0.0 ± 0.0
Asn
3.695AsnAla: 3.695 ± 0.059
0.523AsnCys: 0.523 ± 0.016
2.892AsnAsp: 2.892 ± 0.058
3.068AsnGlu: 3.068 ± 0.04
2.162AsnPhe: 2.162 ± 0.041
3.728AsnGly: 3.728 ± 0.079
1.083AsnHis: 1.083 ± 0.025
3.466AsnIle: 3.466 ± 0.049
2.84AsnLys: 2.84 ± 0.045
4.927AsnLeu: 4.927 ± 0.059
0.963AsnMet: 0.963 ± 0.024
3.05AsnAsn: 3.05 ± 0.057
2.228AsnPro: 2.228 ± 0.037
2.946AsnGln: 2.946 ± 0.043
2.529AsnArg: 2.529 ± 0.037
3.786AsnSer: 3.786 ± 0.051
2.699AsnThr: 2.699 ± 0.056
2.805AsnVal: 2.805 ± 0.05
0.772AsnTrp: 0.772 ± 0.021
1.901AsnTyr: 1.901 ± 0.039
0.0AsnXaa: 0.0 ± 0.0
Pro
2.767ProAla: 2.767 ± 0.042
0.266ProCys: 0.266 ± 0.011
2.515ProAsp: 2.515 ± 0.043
3.065ProGlu: 3.065 ± 0.045
1.643ProPhe: 1.643 ± 0.027
2.616ProGly: 2.616 ± 0.037
0.726ProHis: 0.726 ± 0.02
2.42ProIle: 2.42 ± 0.032
2.02ProLys: 2.02 ± 0.037
3.514ProLeu: 3.514 ± 0.04
0.739ProMet: 0.739 ± 0.021
1.64ProAsn: 1.64 ± 0.03
1.229ProPro: 1.229 ± 0.029
1.617ProGln: 1.617 ± 0.031
1.257ProArg: 1.257 ± 0.027
2.424ProSer: 2.424 ± 0.046
2.024ProThr: 2.024 ± 0.035
2.906ProVal: 2.906 ± 0.044
0.453ProTrp: 0.453 ± 0.017
1.117ProTyr: 1.117 ± 0.032
0.0ProXaa: 0.0 ± 0.0
Gln
3.509GlnAla: 3.509 ± 0.049
0.402GlnCys: 0.402 ± 0.019
1.932GlnAsp: 1.932 ± 0.031
2.339GlnGlu: 2.339 ± 0.039
1.947GlnPhe: 1.947 ± 0.03
2.562GlnGly: 2.562 ± 0.039
0.965GlnHis: 0.965 ± 0.022
2.869GlnIle: 2.869 ± 0.044
2.618GlnLys: 2.618 ± 0.044
5.438GlnLeu: 5.438 ± 0.07
0.968GlnMet: 0.968 ± 0.022
2.16GlnAsn: 2.16 ± 0.039
1.739GlnPro: 1.739 ± 0.035
2.826GlnGln: 2.826 ± 0.058
2.016GlnArg: 2.016 ± 0.039
3.45GlnSer: 3.45 ± 0.049
2.421GlnThr: 2.421 ± 0.037
3.045GlnVal: 3.045 ± 0.045
0.605GlnTrp: 0.605 ± 0.016
1.361GlnTyr: 1.361 ± 0.032
0.0GlnXaa: 0.0 ± 0.0
Arg
3.019ArgAla: 3.019 ± 0.043
0.409ArgCys: 0.409 ± 0.015
2.228ArgAsp: 2.228 ± 0.038
2.831ArgGlu: 2.831 ± 0.051
2.203ArgPhe: 2.203 ± 0.033
2.454ArgGly: 2.454 ± 0.04
0.998ArgHis: 0.998 ± 0.024
2.952ArgIle: 2.952 ± 0.042
2.718ArgLys: 2.718 ± 0.046
4.924ArgLeu: 4.924 ± 0.073
1.009ArgMet: 1.009 ± 0.026
2.146ArgAsn: 2.146 ± 0.034
1.419ArgPro: 1.419 ± 0.03
2.135ArgGln: 2.135 ± 0.044
2.2ArgArg: 2.2 ± 0.045
2.773ArgSer: 2.773 ± 0.041
2.101ArgThr: 2.101 ± 0.039
2.998ArgVal: 2.998 ± 0.041
0.654ArgTrp: 0.654 ± 0.021
1.764ArgTyr: 1.764 ± 0.032
0.0ArgXaa: 0.0 ± 0.0
Ser
5.612SerAla: 5.612 ± 0.063
0.715SerCys: 0.715 ± 0.021
4.524SerAsp: 4.524 ± 0.077
4.829SerGlu: 4.829 ± 0.065
3.455SerPhe: 3.455 ± 0.052
5.892SerGly: 5.892 ± 0.09
1.589SerHis: 1.589 ± 0.034
5.084SerIle: 5.084 ± 0.058
3.852SerLys: 3.852 ± 0.055
7.629SerLeu: 7.629 ± 0.064
1.502SerMet: 1.502 ± 0.028
3.717SerAsn: 3.717 ± 0.057
2.685SerPro: 2.685 ± 0.042
3.579SerGln: 3.579 ± 0.046
3.21SerArg: 3.21 ± 0.049
5.655SerSer: 5.655 ± 0.086
3.819SerThr: 3.819 ± 0.067
4.909SerVal: 4.909 ± 0.069
0.995SerTrp: 0.995 ± 0.03
2.485SerTyr: 2.485 ± 0.053
0.0SerXaa: 0.0 ± 0.0
Thr
4.259ThrAla: 4.259 ± 0.065
0.447ThrCys: 0.447 ± 0.015
3.102ThrAsp: 3.102 ± 0.07
3.278ThrGlu: 3.278 ± 0.045
2.234ThrPhe: 2.234 ± 0.037
4.057ThrGly: 4.057 ± 0.065
1.16ThrHis: 1.16 ± 0.025
3.771ThrIle: 3.771 ± 0.059
2.535ThrLys: 2.535 ± 0.043
5.388ThrLeu: 5.388 ± 0.063
0.968ThrMet: 0.968 ± 0.022
2.798ThrAsn: 2.798 ± 0.064
2.51ThrPro: 2.51 ± 0.04
2.522ThrGln: 2.522 ± 0.037
2.309ThrArg: 2.309 ± 0.037
3.932ThrSer: 3.932 ± 0.074
3.124ThrThr: 3.124 ± 0.067
3.67ThrVal: 3.67 ± 0.073
0.593ThrTrp: 0.593 ± 0.02
1.69ThrTyr: 1.69 ± 0.041
0.0ThrXaa: 0.0 ± 0.0
Val
5.405ValAla: 5.405 ± 0.058
0.644ValCys: 0.644 ± 0.017
4.157ValAsp: 4.157 ± 0.051
4.555ValGlu: 4.555 ± 0.047
2.717ValPhe: 2.717 ± 0.043
4.29ValGly: 4.29 ± 0.053
1.103ValHis: 1.103 ± 0.023
4.512ValIle: 4.512 ± 0.051
3.884ValLys: 3.884 ± 0.052
5.767ValLeu: 5.767 ± 0.064
1.342ValMet: 1.342 ± 0.03
3.503ValAsn: 3.503 ± 0.047
2.228ValPro: 2.228 ± 0.038
1.993ValGln: 1.993 ± 0.033
2.619ValArg: 2.619 ± 0.039
5.413ValSer: 5.413 ± 0.075
4.107ValThr: 4.107 ± 0.081
4.58ValVal: 4.58 ± 0.062
0.75ValTrp: 0.75 ± 0.02
1.92ValTyr: 1.92 ± 0.033
0.0ValXaa: 0.0 ± 0.0
Trp
0.717TrpAla: 0.717 ± 0.02
0.128TrpCys: 0.128 ± 0.009
0.606TrpAsp: 0.606 ± 0.02
0.64TrpGlu: 0.64 ± 0.022
0.596TrpPhe: 0.596 ± 0.018
0.762TrpGly: 0.762 ± 0.022
0.323TrpHis: 0.323 ± 0.015
0.773TrpIle: 0.773 ± 0.023
0.65TrpLys: 0.65 ± 0.019
1.52TrpLeu: 1.52 ± 0.032
0.286TrpMet: 0.286 ± 0.011
0.595TrpAsn: 0.595 ± 0.022
0.428TrpPro: 0.428 ± 0.016
0.816TrpGln: 0.816 ± 0.021
0.704TrpArg: 0.704 ± 0.021
0.955TrpSer: 0.955 ± 0.024
0.583TrpThr: 0.583 ± 0.021
0.849TrpVal: 0.849 ± 0.023
0.184TrpTrp: 0.184 ± 0.011
0.378TrpTyr: 0.378 ± 0.015
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.151TyrAla: 2.151 ± 0.036
0.36TyrCys: 0.36 ± 0.014
1.889TyrAsp: 1.889 ± 0.048
1.722TyrGlu: 1.722 ± 0.033
1.722TyrPhe: 1.722 ± 0.036
2.028TyrGly: 2.028 ± 0.037
0.797TyrHis: 0.797 ± 0.022
1.686TyrIle: 1.686 ± 0.032
1.389TyrLys: 1.389 ± 0.029
3.535TyrLeu: 3.535 ± 0.047
0.544TyrMet: 0.544 ± 0.018
1.293TyrAsn: 1.293 ± 0.03
1.296TyrPro: 1.296 ± 0.026
2.209TyrGln: 2.209 ± 0.038
1.945TyrArg: 1.945 ± 0.038
2.631TyrSer: 2.631 ± 0.046
1.564TyrThr: 1.564 ± 0.034
1.897TyrVal: 1.897 ± 0.031
0.53TyrTrp: 0.53 ± 0.015
1.203TyrTyr: 1.203 ± 0.034
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 5286 proteins (2022666 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski