Amino acid dipepetide frequency for Salmonella virus VSiA

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
11.149AlaAla: 11.149 ± 1.414
1.055AlaCys: 1.055 ± 0.323
6.554AlaAsp: 6.554 ± 0.609
6.328AlaGlu: 6.328 ± 0.782
3.917AlaPhe: 3.917 ± 0.538
7.382AlaGly: 7.382 ± 0.804
1.883AlaHis: 1.883 ± 0.406
5.047AlaIle: 5.047 ± 0.7
6.026AlaLys: 6.026 ± 0.896
8.437AlaLeu: 8.437 ± 0.824
1.808AlaMet: 1.808 ± 0.558
3.616AlaAsn: 3.616 ± 0.606
3.089AlaPro: 3.089 ± 0.482
3.616AlaGln: 3.616 ± 0.669
5.122AlaArg: 5.122 ± 0.655
6.478AlaSer: 6.478 ± 0.696
6.252AlaThr: 6.252 ± 0.968
6.102AlaVal: 6.102 ± 0.757
1.582AlaTrp: 1.582 ± 0.31
3.164AlaTyr: 3.164 ± 0.529
0.0AlaXaa: 0.0 ± 0.0
Cys
1.205CysAla: 1.205 ± 0.35
0.226CysCys: 0.226 ± 0.125
0.753CysAsp: 0.753 ± 0.204
0.753CysGlu: 0.753 ± 0.234
0.377CysPhe: 0.377 ± 0.174
1.582CysGly: 1.582 ± 0.429
0.527CysHis: 0.527 ± 0.215
0.603CysIle: 0.603 ± 0.212
0.829CysLys: 0.829 ± 0.206
0.904CysLeu: 0.904 ± 0.329
0.0CysMet: 0.0 ± 0.0
0.678CysAsn: 0.678 ± 0.23
0.603CysPro: 0.603 ± 0.208
0.753CysGln: 0.753 ± 0.298
0.904CysArg: 0.904 ± 0.311
0.603CysSer: 0.603 ± 0.191
0.377CysThr: 0.377 ± 0.158
0.377CysVal: 0.377 ± 0.176
0.226CysTrp: 0.226 ± 0.121
0.603CysTyr: 0.603 ± 0.208
0.0CysXaa: 0.0 ± 0.0
Asp
7.081AspAla: 7.081 ± 0.657
0.603AspCys: 0.603 ± 0.255
4.294AspAsp: 4.294 ± 0.803
5.273AspGlu: 5.273 ± 0.962
2.335AspPhe: 2.335 ± 0.382
5.348AspGly: 5.348 ± 0.759
0.753AspHis: 0.753 ± 0.234
4.068AspIle: 4.068 ± 0.451
3.766AspLys: 3.766 ± 0.699
5.122AspLeu: 5.122 ± 0.744
1.507AspMet: 1.507 ± 0.367
2.486AspAsn: 2.486 ± 0.483
1.657AspPro: 1.657 ± 0.322
1.13AspGln: 1.13 ± 0.382
2.637AspArg: 2.637 ± 0.564
3.465AspSer: 3.465 ± 0.498
3.992AspThr: 3.992 ± 0.58
3.766AspVal: 3.766 ± 0.576
0.979AspTrp: 0.979 ± 0.275
2.109AspTyr: 2.109 ± 0.36
0.0AspXaa: 0.0 ± 0.0
Glu
6.102GluAla: 6.102 ± 1.099
0.678GluCys: 0.678 ± 0.205
4.369GluAsp: 4.369 ± 0.663
3.691GluGlu: 3.691 ± 0.657
2.486GluPhe: 2.486 ± 0.407
4.52GluGly: 4.52 ± 0.638
1.055GluHis: 1.055 ± 0.367
2.938GluIle: 2.938 ± 0.37
3.842GluLys: 3.842 ± 0.64
5.951GluLeu: 5.951 ± 0.923
2.637GluMet: 2.637 ± 0.402
2.637GluAsn: 2.637 ± 0.555
2.863GluPro: 2.863 ± 0.38
3.164GluGln: 3.164 ± 0.534
3.239GluArg: 3.239 ± 0.524
3.766GluSer: 3.766 ± 0.463
3.917GluThr: 3.917 ± 0.626
3.917GluVal: 3.917 ± 0.515
0.979GluTrp: 0.979 ± 0.232
2.411GluTyr: 2.411 ± 0.385
0.0GluXaa: 0.0 ± 0.0
Phe
2.561PheAla: 2.561 ± 0.387
0.753PheCys: 0.753 ± 0.28
2.787PheAsp: 2.787 ± 0.58
2.411PheGlu: 2.411 ± 0.396
1.13PhePhe: 1.13 ± 0.254
3.164PheGly: 3.164 ± 0.446
0.979PheHis: 0.979 ± 0.302
2.712PheIle: 2.712 ± 0.436
1.431PheLys: 1.431 ± 0.283
1.883PheLeu: 1.883 ± 0.436
0.678PheMet: 0.678 ± 0.237
1.959PheAsn: 1.959 ± 0.455
1.281PhePro: 1.281 ± 0.395
0.829PheGln: 0.829 ± 0.221
1.657PheArg: 1.657 ± 0.3
2.938PheSer: 2.938 ± 0.576
3.013PheThr: 3.013 ± 0.621
2.863PheVal: 2.863 ± 0.501
0.753PheTrp: 0.753 ± 0.276
0.979PheTyr: 0.979 ± 0.237
0.0PheXaa: 0.0 ± 0.0
Gly
6.78GlyAla: 6.78 ± 0.817
1.356GlyCys: 1.356 ± 0.367
4.294GlyAsp: 4.294 ± 0.509
5.047GlyGlu: 5.047 ± 0.551
3.089GlyPhe: 3.089 ± 0.45
5.8GlyGly: 5.8 ± 0.709
1.13GlyHis: 1.13 ± 0.32
3.465GlyIle: 3.465 ± 0.494
4.444GlyLys: 4.444 ± 0.57
6.026GlyLeu: 6.026 ± 0.764
1.959GlyMet: 1.959 ± 0.404
3.766GlyAsn: 3.766 ± 0.493
2.26GlyPro: 2.26 ± 0.41
2.938GlyGln: 2.938 ± 0.427
4.595GlyArg: 4.595 ± 0.628
4.972GlySer: 4.972 ± 0.645
4.52GlyThr: 4.52 ± 0.574
6.252GlyVal: 6.252 ± 0.775
1.13GlyTrp: 1.13 ± 0.322
2.787GlyTyr: 2.787 ± 0.397
0.0GlyXaa: 0.0 ± 0.0
His
1.431HisAla: 1.431 ± 0.269
0.527HisCys: 0.527 ± 0.18
0.979HisAsp: 0.979 ± 0.271
0.829HisGlu: 0.829 ± 0.261
0.678HisPhe: 0.678 ± 0.243
1.055HisGly: 1.055 ± 0.342
0.753HisHis: 0.753 ± 0.197
1.13HisIle: 1.13 ± 0.326
0.979HisLys: 0.979 ± 0.271
1.281HisLeu: 1.281 ± 0.367
0.226HisMet: 0.226 ± 0.162
0.603HisAsn: 0.603 ± 0.187
1.356HisPro: 1.356 ± 0.363
0.829HisGln: 0.829 ± 0.182
1.13HisArg: 1.13 ± 0.29
1.055HisSer: 1.055 ± 0.243
0.678HisThr: 0.678 ± 0.226
1.205HisVal: 1.205 ± 0.322
0.226HisTrp: 0.226 ± 0.127
0.603HisTyr: 0.603 ± 0.244
0.0HisXaa: 0.0 ± 0.0
Ile
5.424IleAla: 5.424 ± 0.775
0.904IleCys: 0.904 ± 0.208
3.164IleAsp: 3.164 ± 0.591
4.218IleGlu: 4.218 ± 0.452
1.507IlePhe: 1.507 ± 0.447
3.842IleGly: 3.842 ± 0.557
0.226IleHis: 0.226 ± 0.132
2.712IleIle: 2.712 ± 0.425
3.164IleLys: 3.164 ± 0.438
2.712IleLeu: 2.712 ± 0.508
1.205IleMet: 1.205 ± 0.275
2.787IleAsn: 2.787 ± 0.509
2.335IlePro: 2.335 ± 0.405
1.808IleGln: 1.808 ± 0.366
2.637IleArg: 2.637 ± 0.426
3.315IleSer: 3.315 ± 0.537
4.068IleThr: 4.068 ± 0.567
2.863IleVal: 2.863 ± 0.419
0.678IleTrp: 0.678 ± 0.239
1.808IleTyr: 1.808 ± 0.412
0.0IleXaa: 0.0 ± 0.0
Lys
5.424LysAla: 5.424 ± 0.842
0.979LysCys: 0.979 ± 0.335
2.486LysAsp: 2.486 ± 0.427
3.39LysGlu: 3.39 ± 0.721
1.808LysPhe: 1.808 ± 0.346
3.992LysGly: 3.992 ± 0.625
1.582LysHis: 1.582 ± 0.418
2.486LysIle: 2.486 ± 0.408
3.164LysLys: 3.164 ± 0.464
5.198LysLeu: 5.198 ± 0.827
2.26LysMet: 2.26 ± 0.578
2.26LysAsn: 2.26 ± 0.425
3.39LysPro: 3.39 ± 0.58
2.26LysGln: 2.26 ± 0.418
3.39LysArg: 3.39 ± 0.628
2.938LysSer: 2.938 ± 0.507
3.917LysThr: 3.917 ± 0.597
3.239LysVal: 3.239 ± 0.614
0.603LysTrp: 0.603 ± 0.202
2.637LysTyr: 2.637 ± 0.431
0.0LysXaa: 0.0 ± 0.0
Leu
7.608LeuAla: 7.608 ± 0.754
1.055LeuCys: 1.055 ± 0.311
4.746LeuAsp: 4.746 ± 0.535
4.972LeuGlu: 4.972 ± 0.612
2.185LeuPhe: 2.185 ± 0.419
4.67LeuGly: 4.67 ± 0.51
1.13LeuHis: 1.13 ± 0.279
2.712LeuIle: 2.712 ± 0.433
4.67LeuLys: 4.67 ± 0.751
5.876LeuLeu: 5.876 ± 0.684
1.733LeuMet: 1.733 ± 0.313
4.068LeuAsn: 4.068 ± 0.564
3.39LeuPro: 3.39 ± 0.534
2.938LeuGln: 2.938 ± 0.581
5.047LeuArg: 5.047 ± 0.697
4.595LeuSer: 4.595 ± 0.623
4.52LeuThr: 4.52 ± 0.595
5.65LeuVal: 5.65 ± 0.704
0.979LeuTrp: 0.979 ± 0.265
2.411LeuTyr: 2.411 ± 0.395
0.0LeuXaa: 0.0 ± 0.0
Met
3.089MetAla: 3.089 ± 0.435
0.452MetCys: 0.452 ± 0.194
1.356MetAsp: 1.356 ± 0.523
1.356MetGlu: 1.356 ± 0.293
0.904MetPhe: 0.904 ± 0.264
1.205MetGly: 1.205 ± 0.248
0.452MetHis: 0.452 ± 0.215
1.205MetIle: 1.205 ± 0.37
1.582MetLys: 1.582 ± 0.296
1.733MetLeu: 1.733 ± 0.365
0.904MetMet: 0.904 ± 0.268
1.205MetAsn: 1.205 ± 0.338
1.055MetPro: 1.055 ± 0.282
1.055MetGln: 1.055 ± 0.243
1.582MetArg: 1.582 ± 0.368
1.507MetSer: 1.507 ± 0.285
2.109MetThr: 2.109 ± 0.415
1.205MetVal: 1.205 ± 0.338
0.151MetTrp: 0.151 ± 0.094
0.753MetTyr: 0.753 ± 0.285
0.0MetXaa: 0.0 ± 0.0
Asn
3.842AsnAla: 3.842 ± 0.581
0.377AsnCys: 0.377 ± 0.16
3.089AsnAsp: 3.089 ± 0.408
2.486AsnGlu: 2.486 ± 0.432
1.507AsnPhe: 1.507 ± 0.299
4.595AsnGly: 4.595 ± 0.583
1.13AsnHis: 1.13 ± 0.319
2.938AsnIle: 2.938 ± 0.466
2.411AsnLys: 2.411 ± 0.683
2.637AsnLeu: 2.637 ± 0.407
0.979AsnMet: 0.979 ± 0.242
2.637AsnAsn: 2.637 ± 0.544
1.733AsnPro: 1.733 ± 0.405
1.281AsnGln: 1.281 ± 0.358
2.863AsnArg: 2.863 ± 0.523
3.013AsnSer: 3.013 ± 0.63
3.013AsnThr: 3.013 ± 0.541
2.712AsnVal: 2.712 ± 0.453
0.753AsnTrp: 0.753 ± 0.214
1.281AsnTyr: 1.281 ± 0.324
0.0AsnXaa: 0.0 ± 0.0
Pro
3.465ProAla: 3.465 ± 0.569
0.452ProCys: 0.452 ± 0.222
3.013ProAsp: 3.013 ± 0.396
4.67ProGlu: 4.67 ± 0.594
1.657ProPhe: 1.657 ± 0.353
2.486ProGly: 2.486 ± 0.659
0.301ProHis: 0.301 ± 0.161
1.582ProIle: 1.582 ± 0.391
1.959ProLys: 1.959 ± 0.381
3.089ProLeu: 3.089 ± 0.461
0.979ProMet: 0.979 ± 0.316
1.733ProAsn: 1.733 ± 0.52
0.527ProPro: 0.527 ± 0.238
1.431ProGln: 1.431 ± 0.341
2.034ProArg: 2.034 ± 0.37
1.733ProSer: 1.733 ± 0.317
2.26ProThr: 2.26 ± 0.331
3.54ProVal: 3.54 ± 0.53
0.075ProTrp: 0.075 ± 0.076
1.13ProTyr: 1.13 ± 0.342
0.0ProXaa: 0.0 ± 0.0
Gln
4.821GlnAla: 4.821 ± 0.682
0.377GlnCys: 0.377 ± 0.173
1.959GlnAsp: 1.959 ± 0.46
2.26GlnGlu: 2.26 ± 0.43
1.507GlnPhe: 1.507 ± 0.347
2.034GlnGly: 2.034 ± 0.451
0.829GlnHis: 0.829 ± 0.278
2.712GlnIle: 2.712 ± 0.457
2.109GlnLys: 2.109 ± 0.54
2.863GlnLeu: 2.863 ± 0.43
1.431GlnMet: 1.431 ± 0.312
1.657GlnAsn: 1.657 ± 0.466
1.582GlnPro: 1.582 ± 0.359
2.863GlnGln: 2.863 ± 0.854
2.561GlnArg: 2.561 ± 0.48
1.733GlnSer: 1.733 ± 0.395
2.411GlnThr: 2.411 ± 0.473
2.637GlnVal: 2.637 ± 0.488
0.829GlnTrp: 0.829 ± 0.273
1.431GlnTyr: 1.431 ± 0.394
0.0GlnXaa: 0.0 ± 0.0
Arg
4.896ArgAla: 4.896 ± 0.551
0.678ArgCys: 0.678 ± 0.226
3.315ArgAsp: 3.315 ± 0.465
2.863ArgGlu: 2.863 ± 0.429
1.808ArgPhe: 1.808 ± 0.329
4.068ArgGly: 4.068 ± 0.603
0.979ArgHis: 0.979 ± 0.264
3.54ArgIle: 3.54 ± 0.577
4.52ArgLys: 4.52 ± 0.677
4.218ArgLeu: 4.218 ± 0.552
1.507ArgMet: 1.507 ± 0.356
3.089ArgAsn: 3.089 ± 0.515
1.959ArgPro: 1.959 ± 0.509
3.39ArgGln: 3.39 ± 0.526
3.691ArgArg: 3.691 ± 0.668
2.26ArgSer: 2.26 ± 0.384
2.863ArgThr: 2.863 ± 0.441
4.068ArgVal: 4.068 ± 0.596
0.904ArgTrp: 0.904 ± 0.268
1.507ArgTyr: 1.507 ± 0.307
0.0ArgXaa: 0.0 ± 0.0
Ser
6.252SerAla: 6.252 ± 0.914
0.301SerCys: 0.301 ± 0.149
3.766SerAsp: 3.766 ± 0.525
2.938SerGlu: 2.938 ± 0.614
3.239SerPhe: 3.239 ± 0.442
5.574SerGly: 5.574 ± 0.734
0.904SerHis: 0.904 ± 0.31
3.013SerIle: 3.013 ± 0.596
2.938SerLys: 2.938 ± 0.489
4.294SerLeu: 4.294 ± 0.473
1.507SerMet: 1.507 ± 0.353
2.411SerAsn: 2.411 ± 0.471
1.883SerPro: 1.883 ± 0.418
1.959SerGln: 1.959 ± 0.567
3.39SerArg: 3.39 ± 0.437
3.691SerSer: 3.691 ± 0.684
3.917SerThr: 3.917 ± 0.622
4.444SerVal: 4.444 ± 0.802
0.753SerTrp: 0.753 ± 0.235
1.959SerTyr: 1.959 ± 0.333
0.0SerXaa: 0.0 ± 0.0
Thr
6.554ThrAla: 6.554 ± 0.775
0.527ThrCys: 0.527 ± 0.217
3.766ThrAsp: 3.766 ± 0.573
3.616ThrGlu: 3.616 ± 0.497
2.411ThrPhe: 2.411 ± 0.481
6.855ThrGly: 6.855 ± 1.153
0.452ThrHis: 0.452 ± 0.159
3.239ThrIle: 3.239 ± 0.458
2.185ThrLys: 2.185 ± 0.42
5.122ThrLeu: 5.122 ± 0.584
1.205ThrMet: 1.205 ± 0.328
2.185ThrAsn: 2.185 ± 0.504
3.54ThrPro: 3.54 ± 0.58
2.712ThrGln: 2.712 ± 0.429
2.561ThrArg: 2.561 ± 0.459
4.294ThrSer: 4.294 ± 0.653
4.444ThrThr: 4.444 ± 0.702
5.198ThrVal: 5.198 ± 0.694
1.281ThrTrp: 1.281 ± 0.318
2.26ThrTyr: 2.26 ± 0.438
0.0ThrXaa: 0.0 ± 0.0
Val
6.328ValAla: 6.328 ± 0.675
0.904ValCys: 0.904 ± 0.287
4.068ValAsp: 4.068 ± 0.399
4.746ValGlu: 4.746 ± 0.65
1.959ValPhe: 1.959 ± 0.483
4.369ValGly: 4.369 ± 0.566
1.281ValHis: 1.281 ± 0.323
3.766ValIle: 3.766 ± 0.502
4.52ValLys: 4.52 ± 0.59
3.842ValLeu: 3.842 ± 0.505
1.281ValMet: 1.281 ± 0.382
3.616ValAsn: 3.616 ± 0.581
2.034ValPro: 2.034 ± 0.359
2.863ValGln: 2.863 ± 0.389
4.52ValArg: 4.52 ± 0.502
3.917ValSer: 3.917 ± 0.576
5.499ValThr: 5.499 ± 0.792
5.876ValVal: 5.876 ± 0.927
1.13ValTrp: 1.13 ± 0.291
2.486ValTyr: 2.486 ± 0.345
0.0ValXaa: 0.0 ± 0.0
Trp
1.055TrpAla: 1.055 ± 0.387
0.151TrpCys: 0.151 ± 0.104
0.979TrpAsp: 0.979 ± 0.274
0.904TrpGlu: 0.904 ± 0.271
0.753TrpPhe: 0.753 ± 0.256
0.904TrpGly: 0.904 ± 0.347
0.452TrpHis: 0.452 ± 0.205
0.452TrpIle: 0.452 ± 0.194
0.678TrpLys: 0.678 ± 0.22
1.808TrpLeu: 1.808 ± 0.336
0.452TrpMet: 0.452 ± 0.186
0.753TrpAsn: 0.753 ± 0.225
0.301TrpPro: 0.301 ± 0.185
0.904TrpGln: 0.904 ± 0.253
0.904TrpArg: 0.904 ± 0.251
1.055TrpSer: 1.055 ± 0.327
0.527TrpThr: 0.527 ± 0.166
1.205TrpVal: 1.205 ± 0.268
0.301TrpTrp: 0.301 ± 0.137
0.452TrpTyr: 0.452 ± 0.205
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.54TyrAla: 3.54 ± 0.579
0.527TyrCys: 0.527 ± 0.167
2.637TyrAsp: 2.637 ± 0.437
2.411TyrGlu: 2.411 ± 0.438
1.507TyrPhe: 1.507 ± 0.313
3.164TyrGly: 3.164 ± 0.567
0.753TyrHis: 0.753 ± 0.199
1.055TyrIle: 1.055 ± 0.313
2.26TyrLys: 2.26 ± 0.422
1.959TyrLeu: 1.959 ± 0.332
0.527TyrMet: 0.527 ± 0.202
1.13TyrAsn: 1.13 ± 0.23
1.281TyrPro: 1.281 ± 0.35
1.883TyrGln: 1.883 ± 0.551
1.657TyrArg: 1.657 ± 0.33
1.808TyrSer: 1.808 ± 0.401
2.109TyrThr: 2.109 ± 0.51
1.883TyrVal: 1.883 ± 0.446
0.678TyrTrp: 0.678 ± 0.197
1.055TyrTyr: 1.055 ± 0.278
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 73 proteins (13276 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski