Amino acid dipepetide frequency for Kriegella aquimaris

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.65AlaAla: 4.65 ± 0.06
0.551AlaCys: 0.551 ± 0.018
3.644AlaAsp: 3.644 ± 0.047
4.088AlaGlu: 4.088 ± 0.06
3.319AlaPhe: 3.319 ± 0.043
4.335AlaGly: 4.335 ± 0.057
1.227AlaHis: 1.227 ± 0.028
5.302AlaIle: 5.302 ± 0.063
4.49AlaLys: 4.49 ± 0.067
6.63AlaLeu: 6.63 ± 0.072
1.682AlaMet: 1.682 ± 0.035
3.495AlaAsn: 3.495 ± 0.051
2.225AlaPro: 2.225 ± 0.042
2.464AlaGln: 2.464 ± 0.045
2.121AlaArg: 2.121 ± 0.035
4.398AlaSer: 4.398 ± 0.061
3.783AlaThr: 3.783 ± 0.053
4.19AlaVal: 4.19 ± 0.06
0.752AlaTrp: 0.752 ± 0.021
2.634AlaTyr: 2.634 ± 0.037
0.0AlaXaa: 0.0 ± 0.0
Cys
0.489CysAla: 0.489 ± 0.017
0.093CysCys: 0.093 ± 0.008
0.41CysAsp: 0.41 ± 0.018
0.431CysGlu: 0.431 ± 0.017
0.393CysPhe: 0.393 ± 0.016
0.589CysGly: 0.589 ± 0.022
0.219CysHis: 0.219 ± 0.014
0.52CysIle: 0.52 ± 0.019
0.441CysLys: 0.441 ± 0.017
0.63CysLeu: 0.63 ± 0.018
0.151CysMet: 0.151 ± 0.009
0.371CysAsn: 0.371 ± 0.014
0.304CysPro: 0.304 ± 0.015
0.239CysGln: 0.239 ± 0.012
0.231CysArg: 0.231 ± 0.011
0.571CysSer: 0.571 ± 0.023
0.443CysThr: 0.443 ± 0.02
0.41CysVal: 0.41 ± 0.017
0.076CysTrp: 0.076 ± 0.007
0.285CysTyr: 0.285 ± 0.013
0.0CysXaa: 0.0 ± 0.0
Asp
3.999AspAla: 3.999 ± 0.047
0.412AspCys: 0.412 ± 0.017
3.237AspAsp: 3.237 ± 0.047
3.718AspGlu: 3.718 ± 0.047
3.743AspPhe: 3.743 ± 0.046
4.582AspGly: 4.582 ± 0.081
1.083AspHis: 1.083 ± 0.027
4.4AspIle: 4.4 ± 0.057
3.874AspLys: 3.874 ± 0.053
5.232AspLeu: 5.232 ± 0.057
1.277AspMet: 1.277 ± 0.03
3.173AspAsn: 3.173 ± 0.045
2.156AspPro: 2.156 ± 0.043
1.735AspGln: 1.735 ± 0.034
2.168AspArg: 2.168 ± 0.037
3.398AspSer: 3.398 ± 0.047
2.909AspThr: 2.909 ± 0.045
3.578AspVal: 3.578 ± 0.049
0.947AspTrp: 0.947 ± 0.026
2.77AspTyr: 2.77 ± 0.043
0.0AspXaa: 0.0 ± 0.0
Glu
4.307GluAla: 4.307 ± 0.058
0.315GluCys: 0.315 ± 0.013
3.612GluAsp: 3.612 ± 0.05
4.603GluGlu: 4.603 ± 0.07
2.739GluPhe: 2.739 ± 0.043
4.101GluGly: 4.101 ± 0.055
1.212GluHis: 1.212 ± 0.027
5.145GluIle: 5.145 ± 0.053
5.72GluLys: 5.72 ± 0.069
6.108GluLeu: 6.108 ± 0.067
1.675GluMet: 1.675 ± 0.032
4.595GluAsn: 4.595 ± 0.054
1.793GluPro: 1.793 ± 0.032
2.265GluGln: 2.265 ± 0.031
2.746GluArg: 2.746 ± 0.039
3.403GluSer: 3.403 ± 0.045
3.567GluThr: 3.567 ± 0.045
4.362GluVal: 4.362 ± 0.06
0.783GluTrp: 0.783 ± 0.023
2.287GluTyr: 2.287 ± 0.041
0.0GluXaa: 0.0 ± 0.0
Phe
2.939PheAla: 2.939 ± 0.042
0.409PheCys: 0.409 ± 0.014
3.465PheAsp: 3.465 ± 0.042
3.39PheGlu: 3.39 ± 0.048
2.67PhePhe: 2.67 ± 0.045
3.715PheGly: 3.715 ± 0.045
0.833PheHis: 0.833 ± 0.023
3.47PheIle: 3.47 ± 0.049
3.334PheLys: 3.334 ± 0.042
4.694PheLeu: 4.694 ± 0.058
1.149PheMet: 1.149 ± 0.028
2.815PheAsn: 2.815 ± 0.043
1.765PhePro: 1.765 ± 0.032
1.547PheGln: 1.547 ± 0.033
1.814PheArg: 1.814 ± 0.03
3.872PheSer: 3.872 ± 0.056
2.917PheThr: 2.917 ± 0.047
3.005PheVal: 3.005 ± 0.04
0.645PheTrp: 0.645 ± 0.02
2.039PheTyr: 2.039 ± 0.037
0.0PheXaa: 0.0 ± 0.0
Gly
4.644GlyAla: 4.644 ± 0.062
0.628GlyCys: 0.628 ± 0.029
3.873GlyAsp: 3.873 ± 0.053
4.047GlyGlu: 4.047 ± 0.045
3.707GlyPhe: 3.707 ± 0.048
5.026GlyGly: 5.026 ± 0.068
1.373GlyHis: 1.373 ± 0.029
5.511GlyIle: 5.511 ± 0.062
5.159GlyLys: 5.159 ± 0.062
6.316GlyLeu: 6.316 ± 0.065
1.738GlyMet: 1.738 ± 0.037
3.994GlyAsn: 3.994 ± 0.056
1.751GlyPro: 1.751 ± 0.035
2.185GlyGln: 2.185 ± 0.037
2.549GlyArg: 2.549 ± 0.042
4.43GlySer: 4.43 ± 0.064
4.237GlyThr: 4.237 ± 0.066
4.646GlyVal: 4.646 ± 0.061
1.03GlyTrp: 1.03 ± 0.026
3.108GlyTyr: 3.108 ± 0.045
0.0GlyXaa: 0.0 ± 0.0
His
1.098HisAla: 1.098 ± 0.03
0.181HisCys: 0.181 ± 0.009
0.912HisAsp: 0.912 ± 0.025
1.078HisGlu: 1.078 ± 0.026
1.126HisPhe: 1.126 ± 0.025
1.303HisGly: 1.303 ± 0.034
0.509HisHis: 0.509 ± 0.015
1.386HisIle: 1.386 ± 0.032
1.195HisLys: 1.195 ± 0.03
1.879HisLeu: 1.879 ± 0.033
0.396HisMet: 0.396 ± 0.015
0.959HisAsn: 0.959 ± 0.021
0.941HisPro: 0.941 ± 0.027
0.709HisGln: 0.709 ± 0.02
0.762HisArg: 0.762 ± 0.022
1.096HisSer: 1.096 ± 0.023
1.04HisThr: 1.04 ± 0.024
0.979HisVal: 0.979 ± 0.023
0.295HisTrp: 0.295 ± 0.012
0.844HisTyr: 0.844 ± 0.023
0.0HisXaa: 0.0 ± 0.0
Ile
5.408IleAla: 5.408 ± 0.065
0.594IleCys: 0.594 ± 0.02
4.776IleAsp: 4.776 ± 0.06
4.789IleGlu: 4.789 ± 0.056
3.352IlePhe: 3.352 ± 0.049
5.133IleGly: 5.133 ± 0.055
1.264IleHis: 1.264 ± 0.025
5.049IleIle: 5.049 ± 0.068
5.1IleLys: 5.1 ± 0.051
6.531IleLeu: 6.531 ± 0.078
1.348IleMet: 1.348 ± 0.027
4.039IleAsn: 4.039 ± 0.057
3.138IlePro: 3.138 ± 0.045
2.26IleGln: 2.26 ± 0.036
2.754IleArg: 2.754 ± 0.039
5.336IleSer: 5.336 ± 0.065
4.386IleThr: 4.386 ± 0.06
4.532IleVal: 4.532 ± 0.06
0.812IleTrp: 0.812 ± 0.02
2.621IleTyr: 2.621 ± 0.036
0.0IleXaa: 0.0 ± 0.0
Lys
4.632LysAla: 4.632 ± 0.054
0.33LysCys: 0.33 ± 0.015
4.13LysAsp: 4.13 ± 0.053
5.783LysGlu: 5.783 ± 0.065
2.721LysPhe: 2.721 ± 0.041
4.706LysGly: 4.706 ± 0.057
1.222LysHis: 1.222 ± 0.028
5.356LysIle: 5.356 ± 0.071
6.37LysLys: 6.37 ± 0.075
6.031LysLeu: 6.031 ± 0.073
1.886LysMet: 1.886 ± 0.033
4.896LysAsn: 4.896 ± 0.058
2.406LysPro: 2.406 ± 0.037
2.281LysGln: 2.281 ± 0.039
2.901LysArg: 2.901 ± 0.039
4.435LysSer: 4.435 ± 0.047
4.222LysThr: 4.222 ± 0.053
4.448LysVal: 4.448 ± 0.058
0.927LysTrp: 0.927 ± 0.027
2.786LysTyr: 2.786 ± 0.045
0.0LysXaa: 0.0 ± 0.0
Leu
6.158LeuAla: 6.158 ± 0.073
0.689LeuCys: 0.689 ± 0.02
5.201LeuAsp: 5.201 ± 0.061
6.049LeuGlu: 6.049 ± 0.071
4.907LeuPhe: 4.907 ± 0.066
6.324LeuGly: 6.324 ± 0.067
1.611LeuHis: 1.611 ± 0.033
6.221LeuIle: 6.221 ± 0.077
7.235LeuLys: 7.235 ± 0.072
8.888LeuLeu: 8.888 ± 0.104
2.165LeuMet: 2.165 ± 0.041
5.315LeuAsn: 5.315 ± 0.057
3.821LeuPro: 3.821 ± 0.048
3.187LeuGln: 3.187 ± 0.046
3.522LeuArg: 3.522 ± 0.048
6.451LeuSer: 6.451 ± 0.062
5.115LeuThr: 5.115 ± 0.06
5.588LeuVal: 5.588 ± 0.059
1.045LeuTrp: 1.045 ± 0.027
3.207LeuTyr: 3.207 ± 0.05
0.0LeuXaa: 0.0 ± 0.0
Met
1.91MetAla: 1.91 ± 0.035
0.134MetCys: 0.134 ± 0.01
1.321MetAsp: 1.321 ± 0.023
1.552MetGlu: 1.552 ± 0.03
0.845MetPhe: 0.845 ± 0.022
1.814MetGly: 1.814 ± 0.037
0.44MetHis: 0.44 ± 0.017
1.388MetIle: 1.388 ± 0.025
1.991MetLys: 1.991 ± 0.034
2.014MetLeu: 2.014 ± 0.034
0.555MetMet: 0.555 ± 0.019
1.303MetAsn: 1.303 ± 0.029
0.987MetPro: 0.987 ± 0.024
0.838MetGln: 0.838 ± 0.021
0.931MetArg: 0.931 ± 0.023
1.308MetSer: 1.308 ± 0.029
1.23MetThr: 1.23 ± 0.029
1.608MetVal: 1.608 ± 0.032
0.214MetTrp: 0.214 ± 0.012
0.669MetTyr: 0.669 ± 0.019
0.0MetXaa: 0.0 ± 0.0
Asn
3.727AsnAla: 3.727 ± 0.055
0.444AsnCys: 0.444 ± 0.016
3.364AsnAsp: 3.364 ± 0.058
3.43AsnGlu: 3.43 ± 0.054
2.936AsnPhe: 2.936 ± 0.053
4.474AsnGly: 4.474 ± 0.065
1.064AsnHis: 1.064 ± 0.027
4.267AsnIle: 4.267 ± 0.057
3.609AsnLys: 3.609 ± 0.05
5.244AsnLeu: 5.244 ± 0.064
1.265AsnMet: 1.265 ± 0.027
3.352AsnAsn: 3.352 ± 0.064
2.721AsnPro: 2.721 ± 0.042
2.039AsnGln: 2.039 ± 0.037
2.311AsnArg: 2.311 ± 0.039
3.691AsnSer: 3.691 ± 0.057
3.496AsnThr: 3.496 ± 0.055
3.312AsnVal: 3.312 ± 0.05
0.806AsnTrp: 0.806 ± 0.023
2.593AsnTyr: 2.593 ± 0.044
0.0AsnXaa: 0.0 ± 0.0
Pro
2.054ProAla: 2.054 ± 0.043
0.19ProCys: 0.19 ± 0.012
2.495ProAsp: 2.495 ± 0.045
3.217ProGlu: 3.217 ± 0.043
1.911ProPhe: 1.911 ± 0.034
2.277ProGly: 2.277 ± 0.044
0.726ProHis: 0.726 ± 0.019
2.756ProIle: 2.756 ± 0.035
2.647ProLys: 2.647 ± 0.038
3.308ProLeu: 3.308 ± 0.048
0.804ProMet: 0.804 ± 0.023
2.354ProAsn: 2.354 ± 0.044
1.1ProPro: 1.1 ± 0.031
1.215ProGln: 1.215 ± 0.024
1.096ProArg: 1.096 ± 0.025
2.399ProSer: 2.399 ± 0.038
2.076ProThr: 2.076 ± 0.038
2.408ProVal: 2.408 ± 0.037
0.455ProTrp: 0.455 ± 0.016
1.513ProTyr: 1.513 ± 0.034
0.0ProXaa: 0.0 ± 0.0
Gln
1.948GlnAla: 1.948 ± 0.04
0.188GlnCys: 0.188 ± 0.011
1.678GlnAsp: 1.678 ± 0.03
2.247GlnGlu: 2.247 ± 0.034
1.555GlnPhe: 1.555 ± 0.031
2.094GlnGly: 2.094 ± 0.037
0.644GlnHis: 0.644 ± 0.023
2.48GlnIle: 2.48 ± 0.035
2.736GlnLys: 2.736 ± 0.038
3.404GlnLeu: 3.404 ± 0.044
0.876GlnMet: 0.876 ± 0.024
2.122GlnAsn: 2.122 ± 0.035
1.123GlnPro: 1.123 ± 0.025
1.364GlnGln: 1.364 ± 0.031
1.379GlnArg: 1.379 ± 0.028
1.973GlnSer: 1.973 ± 0.031
1.806GlnThr: 1.806 ± 0.033
1.947GlnVal: 1.947 ± 0.034
0.483GlnTrp: 0.483 ± 0.017
1.286GlnTyr: 1.286 ± 0.031
0.0GlnXaa: 0.0 ± 0.0
Arg
2.306ArgAla: 2.306 ± 0.035
0.239ArgCys: 0.239 ± 0.012
1.961ArgAsp: 1.961 ± 0.033
2.269ArgGlu: 2.269 ± 0.037
2.037ArgPhe: 2.037 ± 0.035
2.235ArgGly: 2.235 ± 0.039
0.702ArgHis: 0.702 ± 0.022
2.999ArgIle: 2.999 ± 0.044
2.85ArgLys: 2.85 ± 0.043
3.65ArgLeu: 3.65 ± 0.04
1.017ArgMet: 1.017 ± 0.026
2.318ArgAsn: 2.318 ± 0.039
1.423ArgPro: 1.423 ± 0.03
1.207ArgGln: 1.207 ± 0.024
1.479ArgArg: 1.479 ± 0.03
2.194ArgSer: 2.194 ± 0.037
2.125ArgThr: 2.125 ± 0.036
2.14ArgVal: 2.14 ± 0.037
0.52ArgTrp: 0.52 ± 0.018
1.737ArgTyr: 1.737 ± 0.033
0.0ArgXaa: 0.0 ± 0.0
Ser
3.989SerAla: 3.989 ± 0.055
0.639SerCys: 0.639 ± 0.02
3.753SerAsp: 3.753 ± 0.051
4.271SerGlu: 4.271 ± 0.052
3.556SerPhe: 3.556 ± 0.046
5.013SerGly: 5.013 ± 0.066
1.157SerHis: 1.157 ± 0.027
4.874SerIle: 4.874 ± 0.051
4.562SerLys: 4.562 ± 0.048
5.923SerLeu: 5.923 ± 0.071
1.383SerMet: 1.383 ± 0.03
3.636SerAsn: 3.636 ± 0.057
2.301SerPro: 2.301 ± 0.037
2.067SerGln: 2.067 ± 0.038
2.276SerArg: 2.276 ± 0.039
4.277SerSer: 4.277 ± 0.058
3.538SerThr: 3.538 ± 0.045
4.028SerVal: 4.028 ± 0.053
0.801SerTrp: 0.801 ± 0.023
2.706SerTyr: 2.706 ± 0.044
0.0SerXaa: 0.0 ± 0.0
Thr
3.865ThrAla: 3.865 ± 0.047
0.333ThrCys: 0.333 ± 0.017
3.492ThrAsp: 3.492 ± 0.05
3.51ThrGlu: 3.51 ± 0.048
2.847ThrPhe: 2.847 ± 0.041
4.211ThrGly: 4.211 ± 0.058
1.045ThrHis: 1.045 ± 0.024
4.516ThrIle: 4.516 ± 0.053
3.564ThrLys: 3.564 ± 0.051
5.248ThrLeu: 5.248 ± 0.056
1.11ThrMet: 1.11 ± 0.022
3.017ThrAsn: 3.017 ± 0.05
2.557ThrPro: 2.557 ± 0.042
1.738ThrGln: 1.738 ± 0.033
1.715ThrArg: 1.715 ± 0.032
3.766ThrSer: 3.766 ± 0.048
3.386ThrThr: 3.386 ± 0.058
3.776ThrVal: 3.776 ± 0.057
0.688ThrTrp: 0.688 ± 0.02
2.363ThrTyr: 2.363 ± 0.045
0.0ThrXaa: 0.0 ± 0.0
Val
4.4ValAla: 4.4 ± 0.053
0.528ValCys: 0.528 ± 0.02
3.836ValAsp: 3.836 ± 0.048
3.695ValGlu: 3.695 ± 0.052
3.245ValPhe: 3.245 ± 0.047
4.106ValGly: 4.106 ± 0.06
1.158ValHis: 1.158 ± 0.028
4.343ValIle: 4.343 ± 0.053
4.012ValLys: 4.012 ± 0.052
6.183ValLeu: 6.183 ± 0.062
1.404ValMet: 1.404 ± 0.033
3.308ValAsn: 3.308 ± 0.044
2.489ValPro: 2.489 ± 0.035
1.978ValGln: 1.978 ± 0.033
2.301ValArg: 2.301 ± 0.042
4.391ValSer: 4.391 ± 0.046
3.545ValThr: 3.545 ± 0.059
4.405ValVal: 4.405 ± 0.061
0.713ValTrp: 0.713 ± 0.022
2.3ValTyr: 2.3 ± 0.035
0.0ValXaa: 0.0 ± 0.0
Trp
0.816TrpAla: 0.816 ± 0.023
0.097TrpCys: 0.097 ± 0.008
0.758TrpAsp: 0.758 ± 0.022
0.804TrpGlu: 0.804 ± 0.025
0.647TrpPhe: 0.647 ± 0.018
0.954TrpGly: 0.954 ± 0.026
0.314TrpHis: 0.314 ± 0.014
0.764TrpIle: 0.764 ± 0.022
0.929TrpLys: 0.929 ± 0.023
1.1TrpLeu: 1.1 ± 0.028
0.362TrpMet: 0.362 ± 0.015
0.788TrpAsn: 0.788 ± 0.021
0.432TrpPro: 0.432 ± 0.019
0.518TrpGln: 0.518 ± 0.017
0.538TrpArg: 0.538 ± 0.02
0.793TrpSer: 0.793 ± 0.022
0.651TrpThr: 0.651 ± 0.023
0.775TrpVal: 0.775 ± 0.023
0.196TrpTrp: 0.196 ± 0.012
0.494TrpTyr: 0.494 ± 0.018
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.642TyrAla: 2.642 ± 0.043
0.303TyrCys: 0.303 ± 0.012
2.475TyrAsp: 2.475 ± 0.037
2.365TyrGlu: 2.365 ± 0.039
2.23TyrPhe: 2.23 ± 0.037
2.961TyrGly: 2.961 ± 0.04
0.884TyrHis: 0.884 ± 0.024
2.476TyrIle: 2.476 ± 0.036
2.65TyrLys: 2.65 ± 0.043
3.687TyrLeu: 3.687 ± 0.05
0.807TyrMet: 0.807 ± 0.021
2.292TyrAsn: 2.292 ± 0.041
1.571TyrPro: 1.571 ± 0.03
1.498TyrGln: 1.498 ± 0.032
1.81TyrArg: 1.81 ± 0.039
2.569TyrSer: 2.569 ± 0.043
2.273TyrThr: 2.273 ± 0.038
2.205TyrVal: 2.205 ± 0.033
0.541TyrTrp: 0.541 ± 0.019
1.737TyrTyr: 1.737 ± 0.035
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4956 proteins (1798520 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski