Amino acid dipepetide frequency for Wenzhou picorna-like virus 52

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
6.427AlaAla: 6.427 ± 2.179
1.89AlaCys: 1.89 ± 0.299
4.537AlaAsp: 4.537 ± 1.089
5.293AlaGlu: 5.293 ± 0.697
4.159AlaPhe: 4.159 ± 0.796
3.025AlaGly: 3.025 ± 0.494
2.647AlaHis: 2.647 ± 0.696
7.183AlaIle: 7.183 ± 1.69
4.159AlaLys: 4.159 ± 1.49
4.915AlaLeu: 4.915 ± 1.887
3.403AlaMet: 3.403 ± 0.399
2.647AlaAsn: 2.647 ± 0.693
4.159AlaPro: 4.159 ± 1.982
1.512AlaGln: 1.512 ± 0.1
3.403AlaArg: 3.403 ± 0.399
5.293AlaSer: 5.293 ± 4.163
3.781AlaThr: 3.781 ± 1.486
6.049AlaVal: 6.049 ± 1.094
1.134AlaTrp: 1.134 ± 0.099
1.89AlaTyr: 1.89 ± 0.993
0.0AlaXaa: 0.0 ± 0.0
Cys
0.378CysAla: 0.378 ± 0.496
0.756CysCys: 0.756 ± 0.397
0.756CysAsp: 0.756 ± 0.397
0.756CysGlu: 0.756 ± 0.397
1.512CysPhe: 1.512 ± 0.794
1.512CysGly: 1.512 ± 0.794
0.756CysHis: 0.756 ± 0.397
0.378CysIle: 0.378 ± 0.199
0.756CysLys: 0.756 ± 0.397
0.0CysLeu: 0.0 ± 0.0
1.134CysMet: 1.134 ± 0.596
0.756CysAsn: 0.756 ± 0.397
0.756CysPro: 0.756 ± 0.297
0.0CysGln: 0.0 ± 0.0
1.134CysArg: 1.134 ± 1.487
0.756CysSer: 0.756 ± 0.397
1.134CysThr: 1.134 ± 0.596
1.134CysVal: 1.134 ± 0.099
0.378CysTrp: 0.378 ± 0.496
0.756CysTyr: 0.756 ± 0.992
0.0CysXaa: 0.0 ± 0.0
Asp
4.537AspAla: 4.537 ± 0.994
0.378AspCys: 0.378 ± 0.199
3.025AspAsp: 3.025 ± 0.494
3.781AspGlu: 3.781 ± 0.597
3.781AspPhe: 3.781 ± 0.792
2.647AspGly: 2.647 ± 0.693
0.378AspHis: 0.378 ± 0.199
4.537AspIle: 4.537 ± 1.089
2.268AspLys: 2.268 ± 1.192
6.049AspLeu: 6.049 ± 0.4
1.89AspMet: 1.89 ± 1.09
3.025AspAsn: 3.025 ± 0.2
3.403AspPro: 3.403 ± 1.684
1.89AspGln: 1.89 ± 1.09
2.268AspArg: 2.268 ± 0.497
4.537AspSer: 4.537 ± 0.3
3.781AspThr: 3.781 ± 1.486
3.025AspVal: 3.025 ± 0.494
0.0AspTrp: 0.0 ± 0.0
3.025AspTyr: 3.025 ± 0.2
0.0AspXaa: 0.0 ± 0.0
Glu
3.403GluAla: 3.403 ± 0.99
1.512GluCys: 1.512 ± 0.794
4.537GluAsp: 4.537 ± 0.3
7.94GluGlu: 7.94 ± 0.699
1.512GluPhe: 1.512 ± 0.794
1.512GluGly: 1.512 ± 0.1
2.268GluHis: 2.268 ± 1.192
1.134GluIle: 1.134 ± 0.596
4.537GluLys: 4.537 ± 2.383
6.427GluLeu: 6.427 ± 1.987
1.134GluMet: 1.134 ± 0.099
1.512GluAsn: 1.512 ± 0.794
3.781GluPro: 3.781 ± 1.986
1.512GluGln: 1.512 ± 0.1
1.512GluArg: 1.512 ± 0.1
3.403GluSer: 3.403 ± 0.399
7.183GluThr: 7.183 ± 1.69
5.293GluVal: 5.293 ± 0.003
1.512GluTrp: 1.512 ± 0.794
3.025GluTyr: 3.025 ± 0.2
0.0GluXaa: 0.0 ± 0.0
Phe
5.293PheAla: 5.293 ± 0.697
0.0PheCys: 0.0 ± 0.0
2.268PheAsp: 2.268 ± 0.197
3.403PheGlu: 3.403 ± 1.093
3.025PhePhe: 3.025 ± 1.189
4.915PheGly: 4.915 ± 0.196
1.89PheHis: 1.89 ± 0.396
1.512PheIle: 1.512 ± 0.794
1.89PheLys: 1.89 ± 0.993
4.537PheLeu: 4.537 ± 0.394
0.378PheMet: 0.378 ± 0.496
0.756PheAsn: 0.756 ± 0.297
2.268PhePro: 2.268 ± 0.197
1.134PheGln: 1.134 ± 0.099
2.647PheArg: 2.647 ± 0.693
3.403PheSer: 3.403 ± 0.99
3.025PheThr: 3.025 ± 0.894
3.025PheVal: 3.025 ± 0.494
0.756PheTrp: 0.756 ± 0.297
1.134PheTyr: 1.134 ± 0.099
0.0PheXaa: 0.0 ± 0.0
Gly
3.025GlyAla: 3.025 ± 2.577
1.134GlyCys: 1.134 ± 0.793
3.781GlyAsp: 3.781 ± 0.597
1.512GlyGlu: 1.512 ± 0.594
2.647GlyPhe: 2.647 ± 0.696
5.293GlyGly: 5.293 ± 0.697
1.134GlyHis: 1.134 ± 0.596
4.159GlyIle: 4.159 ± 1.982
4.537GlyLys: 4.537 ± 0.994
4.915GlyLeu: 4.915 ± 0.499
1.134GlyMet: 1.134 ± 0.099
3.025GlyAsn: 3.025 ± 1.189
3.025GlyPro: 3.025 ± 0.2
2.268GlyGln: 2.268 ± 0.892
5.671GlyArg: 5.671 ± 1.59
4.915GlySer: 4.915 ± 0.89
5.293GlyThr: 5.293 ± 0.691
4.915GlyVal: 4.915 ± 0.499
0.756GlyTrp: 0.756 ± 0.297
3.025GlyTyr: 3.025 ± 1.189
0.0GlyXaa: 0.0 ± 0.0
His
3.025HisAla: 3.025 ± 0.494
0.756HisCys: 0.756 ± 0.397
0.378HisAsp: 0.378 ± 0.199
1.89HisGlu: 1.89 ± 0.993
1.89HisPhe: 1.89 ± 0.299
2.268HisGly: 2.268 ± 0.197
0.378HisHis: 0.378 ± 0.496
4.537HisIle: 4.537 ± 0.994
0.756HisLys: 0.756 ± 0.297
0.378HisLeu: 0.378 ± 0.199
0.756HisMet: 0.756 ± 0.397
0.756HisAsn: 0.756 ± 0.397
0.756HisPro: 0.756 ± 0.297
0.0HisGln: 0.0 ± 0.0
0.756HisArg: 0.756 ± 0.992
1.89HisSer: 1.89 ± 0.396
0.756HisThr: 0.756 ± 0.297
1.512HisVal: 1.512 ± 0.1
0.378HisTrp: 0.378 ± 0.496
0.756HisTyr: 0.756 ± 0.297
0.0HisXaa: 0.0 ± 0.0
Ile
4.915IleAla: 4.915 ± 0.499
1.134IleCys: 1.134 ± 0.596
4.537IleAsp: 4.537 ± 0.3
3.025IleGlu: 3.025 ± 0.494
2.268IlePhe: 2.268 ± 0.497
4.537IleGly: 4.537 ± 0.394
0.378IleHis: 0.378 ± 0.199
1.89IleIle: 1.89 ± 0.396
1.89IleLys: 1.89 ± 1.09
3.781IleLeu: 3.781 ± 0.597
0.756IleMet: 0.756 ± 0.397
2.268IleAsn: 2.268 ± 0.497
3.025IlePro: 3.025 ± 0.494
0.756IleGln: 0.756 ± 0.397
1.134IleArg: 1.134 ± 0.596
6.427IleSer: 6.427 ± 0.599
4.915IleThr: 4.915 ± 1.193
7.183IleVal: 7.183 ± 0.996
0.756IleTrp: 0.756 ± 0.397
1.512IleTyr: 1.512 ± 0.794
0.0IleXaa: 0.0 ± 0.0
Lys
5.293LysAla: 5.293 ± 1.392
1.134LysCys: 1.134 ± 0.596
2.268LysAsp: 2.268 ± 0.497
4.159LysGlu: 4.159 ± 2.185
3.403LysPhe: 3.403 ± 0.296
1.512LysGly: 1.512 ± 0.594
2.268LysHis: 2.268 ± 0.497
2.647LysIle: 2.647 ± 1.39
2.268LysLys: 2.268 ± 1.192
5.293LysLeu: 5.293 ± 1.392
1.512LysMet: 1.512 ± 0.1
0.756LysAsn: 0.756 ± 0.397
2.268LysPro: 2.268 ± 0.892
3.025LysGln: 3.025 ± 0.894
2.268LysArg: 2.268 ± 0.497
5.293LysSer: 5.293 ± 0.691
3.403LysThr: 3.403 ± 1.093
4.537LysVal: 4.537 ± 2.383
1.89LysTrp: 1.89 ± 0.993
2.647LysTyr: 2.647 ± 0.696
0.0LysXaa: 0.0 ± 0.0
Leu
6.049LeuAla: 6.049 ± 0.4
0.378LeuCys: 0.378 ± 0.199
5.671LeuAsp: 5.671 ± 0.201
4.537LeuGlu: 4.537 ± 1.689
3.781LeuPhe: 3.781 ± 0.792
3.781LeuGly: 3.781 ± 0.597
2.647LeuHis: 2.647 ± 0.693
2.647LeuIle: 2.647 ± 1.39
4.537LeuLys: 4.537 ± 0.994
4.537LeuLeu: 4.537 ± 0.994
0.756LeuMet: 0.756 ± 0.397
2.268LeuAsn: 2.268 ± 0.197
4.537LeuPro: 4.537 ± 0.394
3.403LeuGln: 3.403 ± 1.093
4.915LeuArg: 4.915 ± 0.89
6.427LeuSer: 6.427 ± 1.293
8.318LeuThr: 8.318 ± 3.269
4.159LeuVal: 4.159 ± 1.49
0.756LeuTrp: 0.756 ± 0.297
3.403LeuTyr: 3.403 ± 1.093
0.0LeuXaa: 0.0 ± 0.0
Met
3.403MetAla: 3.403 ± 0.399
1.134MetCys: 1.134 ± 0.099
0.756MetAsp: 0.756 ± 0.397
0.756MetGlu: 0.756 ± 0.397
1.512MetPhe: 1.512 ± 0.794
1.512MetGly: 1.512 ± 0.594
0.0MetHis: 0.0 ± 0.0
0.378MetIle: 0.378 ± 0.199
2.268MetLys: 2.268 ± 0.497
1.512MetLeu: 1.512 ± 1.289
0.756MetMet: 0.756 ± 0.992
1.512MetAsn: 1.512 ± 1.289
1.89MetPro: 1.89 ± 0.396
1.134MetGln: 1.134 ± 0.596
1.134MetArg: 1.134 ± 0.596
3.025MetSer: 3.025 ± 0.2
2.268MetThr: 2.268 ± 1.192
1.89MetVal: 1.89 ± 1.09
1.134MetTrp: 1.134 ± 0.099
0.378MetTyr: 0.378 ± 0.199
0.0MetXaa: 0.0 ± 0.0
Asn
3.781AsnAla: 3.781 ± 1.292
0.378AsnCys: 0.378 ± 0.496
0.756AsnAsp: 0.756 ± 0.397
1.512AsnGlu: 1.512 ± 0.594
2.268AsnPhe: 2.268 ± 1.586
3.403AsnGly: 3.403 ± 0.296
1.512AsnHis: 1.512 ± 0.794
1.512AsnIle: 1.512 ± 0.1
2.647AsnLys: 2.647 ± 0.696
3.403AsnLeu: 3.403 ± 0.99
0.756AsnMet: 0.756 ± 0.397
3.781AsnAsn: 3.781 ± 1.486
2.647AsnPro: 2.647 ± 0.693
1.134AsnGln: 1.134 ± 0.099
0.0AsnArg: 0.0 ± 0.0
3.403AsnSer: 3.403 ± 0.99
2.647AsnThr: 2.647 ± 0.693
3.025AsnVal: 3.025 ± 1.189
0.378AsnTrp: 0.378 ± 0.199
1.89AsnTyr: 1.89 ± 0.299
0.0AsnXaa: 0.0 ± 0.0
Pro
4.915ProAla: 4.915 ± 0.499
0.756ProCys: 0.756 ± 0.297
3.403ProAsp: 3.403 ± 0.99
4.159ProGlu: 4.159 ± 0.101
2.647ProPhe: 2.647 ± 1.387
4.159ProGly: 4.159 ± 0.796
1.512ProHis: 1.512 ± 0.594
2.647ProIle: 2.647 ± 0.696
3.403ProLys: 3.403 ± 0.99
3.403ProLeu: 3.403 ± 1.093
1.134ProMet: 1.134 ± 0.099
0.756ProAsn: 0.756 ± 0.397
1.89ProPro: 1.89 ± 0.396
1.89ProGln: 1.89 ± 0.396
0.378ProArg: 0.378 ± 0.199
3.781ProSer: 3.781 ± 0.097
4.915ProThr: 4.915 ± 2.973
3.403ProVal: 3.403 ± 1.684
0.378ProTrp: 0.378 ± 0.199
1.134ProTyr: 1.134 ± 0.099
0.0ProXaa: 0.0 ± 0.0
Gln
3.781GlnAla: 3.781 ± 0.097
0.756GlnCys: 0.756 ± 0.397
1.89GlnAsp: 1.89 ± 0.396
1.512GlnGlu: 1.512 ± 0.1
1.134GlnPhe: 1.134 ± 0.596
1.89GlnGly: 1.89 ± 0.396
1.134GlnHis: 1.134 ± 0.099
1.512GlnIle: 1.512 ± 0.594
2.268GlnLys: 2.268 ± 0.197
2.647GlnLeu: 2.647 ± 0.696
1.134GlnMet: 1.134 ± 0.793
1.512GlnAsn: 1.512 ± 0.794
0.756GlnPro: 0.756 ± 0.397
1.89GlnGln: 1.89 ± 0.993
1.134GlnArg: 1.134 ± 0.793
2.268GlnSer: 2.268 ± 0.892
1.134GlnThr: 1.134 ± 0.099
0.756GlnVal: 0.756 ± 0.297
0.378GlnTrp: 0.378 ± 0.199
0.0GlnTyr: 0.0 ± 0.0
0.0GlnXaa: 0.0 ± 0.0
Arg
1.89ArgAla: 1.89 ± 1.09
0.378ArgCys: 0.378 ± 0.199
2.268ArgAsp: 2.268 ± 0.197
4.159ArgGlu: 4.159 ± 1.49
2.268ArgPhe: 2.268 ± 0.197
2.268ArgGly: 2.268 ± 0.497
0.378ArgHis: 0.378 ± 0.496
1.134ArgIle: 1.134 ± 0.099
3.781ArgLys: 3.781 ± 1.292
2.268ArgLeu: 2.268 ± 0.892
1.512ArgMet: 1.512 ± 0.1
1.134ArgAsn: 1.134 ± 0.099
1.89ArgPro: 1.89 ± 0.299
0.0ArgGln: 0.0 ± 0.0
1.89ArgArg: 1.89 ± 0.396
3.025ArgSer: 3.025 ± 0.2
1.89ArgThr: 1.89 ± 1.09
3.025ArgVal: 3.025 ± 0.2
0.756ArgTrp: 0.756 ± 0.297
3.025ArgTyr: 3.025 ± 0.2
0.0ArgXaa: 0.0 ± 0.0
Ser
4.915SerAla: 4.915 ± 0.196
1.134SerCys: 1.134 ± 0.793
4.537SerAsp: 4.537 ± 0.3
3.025SerGlu: 3.025 ± 0.894
2.647SerPhe: 2.647 ± 0.693
8.696SerGly: 8.696 ± 3.07
1.134SerHis: 1.134 ± 0.793
4.537SerIle: 4.537 ± 1.689
3.781SerLys: 3.781 ± 1.292
9.83SerLeu: 9.83 ± 1.086
1.89SerMet: 1.89 ± 0.396
1.512SerAsn: 1.512 ± 0.594
4.159SerPro: 4.159 ± 1.287
1.89SerGln: 1.89 ± 1.09
1.512SerArg: 1.512 ± 1.289
3.781SerSer: 3.781 ± 0.597
5.671SerThr: 5.671 ± 0.493
4.159SerVal: 4.159 ± 0.796
0.378SerTrp: 0.378 ± 0.199
2.268SerTyr: 2.268 ± 0.197
0.0SerXaa: 0.0 ± 0.0
Thr
4.915ThrAla: 4.915 ± 0.499
0.378ThrCys: 0.378 ± 0.199
6.049ThrAsp: 6.049 ± 3.072
3.403ThrGlu: 3.403 ± 1.093
0.756ThrPhe: 0.756 ± 0.397
3.781ThrGly: 3.781 ± 1.486
0.756ThrHis: 0.756 ± 0.992
7.561ThrIle: 7.561 ± 0.194
5.671ThrLys: 5.671 ± 0.896
6.427ThrLeu: 6.427 ± 0.599
3.025ThrMet: 3.025 ± 0.494
3.781ThrAsn: 3.781 ± 0.792
6.049ThrPro: 6.049 ± 0.294
3.025ThrGln: 3.025 ± 0.2
1.89ThrArg: 1.89 ± 0.299
2.268ThrSer: 2.268 ± 0.197
3.025ThrThr: 3.025 ± 1.189
6.049ThrVal: 6.049 ± 3.072
0.378ThrTrp: 0.378 ± 0.496
2.647ThrTyr: 2.647 ± 0.001
0.0ThrXaa: 0.0 ± 0.0
Val
3.403ValAla: 3.403 ± 1.093
1.134ValCys: 1.134 ± 0.099
4.915ValAsp: 4.915 ± 0.196
5.671ValGlu: 5.671 ± 0.896
4.537ValPhe: 4.537 ± 0.394
4.915ValGly: 4.915 ± 0.196
2.647ValHis: 2.647 ± 0.693
4.159ValIle: 4.159 ± 0.593
3.781ValLys: 3.781 ± 1.292
4.159ValLeu: 4.159 ± 0.796
2.647ValMet: 2.647 ± 0.282
3.781ValAsn: 3.781 ± 0.792
2.647ValPro: 2.647 ± 0.001
2.647ValGln: 2.647 ± 0.693
3.781ValArg: 3.781 ± 1.292
4.159ValSer: 4.159 ± 0.593
4.537ValThr: 4.537 ± 1.783
4.537ValVal: 4.537 ± 0.3
0.378ValTrp: 0.378 ± 0.496
2.647ValTyr: 2.647 ± 0.693
0.0ValXaa: 0.0 ± 0.0
Trp
0.378TrpAla: 0.378 ± 0.496
0.0TrpCys: 0.0 ± 0.0
0.378TrpAsp: 0.378 ± 0.496
1.512TrpGlu: 1.512 ± 0.794
0.756TrpPhe: 0.756 ± 0.297
1.134TrpGly: 1.134 ± 0.099
0.378TrpHis: 0.378 ± 0.199
0.378TrpIle: 0.378 ± 0.199
1.134TrpLys: 1.134 ± 0.099
0.378TrpLeu: 0.378 ± 0.199
0.756TrpMet: 0.756 ± 0.512
2.268TrpAsn: 2.268 ± 0.892
0.0TrpPro: 0.0 ± 0.0
0.378TrpGln: 0.378 ± 0.496
0.378TrpArg: 0.378 ± 0.496
1.134TrpSer: 1.134 ± 0.596
1.512TrpThr: 1.512 ± 0.794
0.378TrpVal: 0.378 ± 0.496
0.378TrpTrp: 0.378 ± 0.199
0.756TrpTyr: 0.756 ± 0.297
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.781TyrAla: 3.781 ± 0.792
0.378TyrCys: 0.378 ± 0.199
1.512TyrAsp: 1.512 ± 0.594
2.647TyrGlu: 2.647 ± 1.39
0.756TyrPhe: 0.756 ± 0.397
3.403TyrGly: 3.403 ± 0.399
0.378TyrHis: 0.378 ± 0.199
2.647TyrIle: 2.647 ± 0.696
1.512TyrLys: 1.512 ± 0.794
2.647TyrLeu: 2.647 ± 1.387
1.512TyrMet: 1.512 ± 0.794
3.025TyrAsn: 3.025 ± 0.494
0.756TyrPro: 0.756 ± 0.397
0.0TyrGln: 0.0 ± 0.0
1.134TyrArg: 1.134 ± 0.596
2.268TyrSer: 2.268 ± 0.892
2.647TyrThr: 2.647 ± 0.001
3.025TyrVal: 3.025 ± 0.494
1.89TyrTrp: 1.89 ± 0.396
0.756TyrTyr: 0.756 ± 0.297
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2 proteins (2646 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski