Amino acid dipepetide frequency for Desulfobacterium autotrophicum (strain ATCC 43914 / DSM 3382 / HRM2)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	7.364AlaAla: 7.364 ± 0.096	1.245AlaCys: 1.245 ± 0.029	4.266AlaAsp: 4.266 ± 0.05	4.288AlaGlu: 4.288 ± 0.06	3.748AlaPhe: 3.748 ± 0.049	6.758AlaGly: 6.758 ± 0.073	1.574AlaHis: 1.574 ± 0.032	5.389AlaIle: 5.389 ± 0.06	3.962AlaLys: 3.962 ± 0.056	8.98AlaLeu: 8.98 ± 0.085	2.959AlaMet: 2.959 ± 0.044	2.437AlaAsn: 2.437 ± 0.042	2.714AlaPro: 2.714 ± 0.044	2.624AlaGln: 2.624 ± 0.041	4.475AlaArg: 4.475 ± 0.056	4.376AlaSer: 4.376 ± 0.051	3.937AlaThr: 3.937 ± 0.05	6.128AlaVal: 6.128 ± 0.07	0.914AlaTrp: 0.914 ± 0.028	2.125AlaTyr: 2.125 ± 0.041	0.0AlaXaa: 0.0 ± 0.0
Cys	0.92CysAla: 0.92 ± 0.026	0.284CysCys: 0.284 ± 0.017	0.662CysAsp: 0.662 ± 0.021	0.62CysGlu: 0.62 ± 0.021	0.67CysPhe: 0.67 ± 0.02	1.212CysGly: 1.212 ± 0.033	0.476CysHis: 0.476 ± 0.021	0.823CysIle: 0.823 ± 0.024	0.588CysLys: 0.588 ± 0.021	1.335CysLeu: 1.335 ± 0.027	0.338CysMet: 0.338 ± 0.017	0.473CysAsn: 0.473 ± 0.019	0.826CysPro: 0.826 ± 0.029	0.43CysGln: 0.43 ± 0.018	0.822CysArg: 0.822 ± 0.024	0.873CysSer: 0.873 ± 0.025	0.697CysThr: 0.697 ± 0.026	0.778CysVal: 0.778 ± 0.024	0.138CysTrp: 0.138 ± 0.01	0.362CysTyr: 0.362 ± 0.014	0.0CysXaa: 0.0 ± 0.0
Asp	3.999AspAla: 3.999 ± 0.049	0.645AspCys: 0.645 ± 0.021	2.764AspAsp: 2.764 ± 0.054	3.346AspGlu: 3.346 ± 0.048	2.737AspPhe: 2.737 ± 0.047	3.455AspGly: 3.455 ± 0.06	1.332AspHis: 1.332 ± 0.026	4.083AspIle: 4.083 ± 0.055	3.086AspLys: 3.086 ± 0.05	6.389AspLeu: 6.389 ± 0.063	1.516AspMet: 1.516 ± 0.031	2.081AspAsn: 2.081 ± 0.042	3.036AspPro: 3.036 ± 0.048	2.233AspGln: 2.233 ± 0.043	3.31AspArg: 3.31 ± 0.041	2.831AspSer: 2.831 ± 0.043	2.943AspThr: 2.943 ± 0.042	3.133AspVal: 3.133 ± 0.047	0.603AspTrp: 0.603 ± 0.02	1.843AspTyr: 1.843 ± 0.036	0.0AspXaa: 0.0 ± 0.0
Glu	4.753GluAla: 4.753 ± 0.059	0.541GluCys: 0.541 ± 0.016	2.848GluAsp: 2.848 ± 0.045	3.387GluGlu: 3.387 ± 0.056	2.27GluPhe: 2.27 ± 0.037	3.178GluGly: 3.178 ± 0.045	1.158GluHis: 1.158 ± 0.032	5.184GluIle: 5.184 ± 0.059	5.084GluLys: 5.084 ± 0.069	5.399GluLeu: 5.399 ± 0.071	1.859GluMet: 1.859 ± 0.035	3.061GluAsn: 3.061 ± 0.042	2.166GluPro: 2.166 ± 0.041	2.495GluGln: 2.495 ± 0.039	3.51GluArg: 3.51 ± 0.049	3.189GluSer: 3.189 ± 0.048	4.069GluThr: 4.069 ± 0.049	3.409GluVal: 3.409 ± 0.051	0.557GluTrp: 0.557 ± 0.018	1.549GluTyr: 1.549 ± 0.034	0.0GluXaa: 0.0 ± 0.0
Phe	3.225PheAla: 3.225 ± 0.053	0.718PheCys: 0.718 ± 0.022	2.823PheAsp: 2.823 ± 0.044	2.518PheGlu: 2.518 ± 0.044	2.61PhePhe: 2.61 ± 0.051	3.099PheGly: 3.099 ± 0.047	1.011PheHis: 1.011 ± 0.024	3.009PheIle: 3.009 ± 0.043	2.751PheLys: 2.751 ± 0.044	4.57PheLeu: 4.57 ± 0.059	1.323PheMet: 1.323 ± 0.032	1.998PheAsn: 1.998 ± 0.035	1.891PhePro: 1.891 ± 0.041	1.541PheGln: 1.541 ± 0.029	2.008PheArg: 2.008 ± 0.037	3.616PheSer: 3.616 ± 0.044	2.556PheThr: 2.556 ± 0.044	2.908PheVal: 2.908 ± 0.041	0.551PheTrp: 0.551 ± 0.018	1.52PheTyr: 1.52 ± 0.032	0.0PheXaa: 0.0 ± 0.0
Gly	5.504GlyAla: 5.504 ± 0.066	1.214GlyCys: 1.214 ± 0.033	3.499GlyAsp: 3.499 ± 0.047	4.05GlyGlu: 4.05 ± 0.045	3.895GlyPhe: 3.895 ± 0.05	5.22GlyGly: 5.22 ± 0.073	1.506GlyHis: 1.506 ± 0.032	6.087GlyIle: 6.087 ± 0.067	4.818GlyLys: 4.818 ± 0.054	7.289GlyLeu: 7.289 ± 0.071	2.491GlyMet: 2.491 ± 0.042	2.628GlyAsn: 2.628 ± 0.038	2.303GlyPro: 2.303 ± 0.036	2.492GlyGln: 2.492 ± 0.039	3.894GlyArg: 3.894 ± 0.051	4.218GlySer: 4.218 ± 0.058	4.193GlyThr: 4.193 ± 0.057	5.452GlyVal: 5.452 ± 0.059	0.866GlyTrp: 0.866 ± 0.023	2.494GlyTyr: 2.494 ± 0.043	0.0GlyXaa: 0.0 ± 0.0
His	1.458HisAla: 1.458 ± 0.027	0.345HisCys: 0.345 ± 0.015	1.134HisAsp: 1.134 ± 0.028	1.195HisGlu: 1.195 ± 0.028	0.976HisPhe: 0.976 ± 0.025	1.771HisGly: 1.771 ± 0.039	0.578HisHis: 0.578 ± 0.02	1.31HisIle: 1.31 ± 0.029	0.935HisLys: 0.935 ± 0.027	2.2HisLeu: 2.2 ± 0.04	0.528HisMet: 0.528 ± 0.016	0.727HisAsn: 0.727 ± 0.023	1.27HisPro: 1.27 ± 0.03	0.732HisGln: 0.732 ± 0.021	1.173HisArg: 1.173 ± 0.031	1.116HisSer: 1.116 ± 0.027	1.117HisThr: 1.117 ± 0.029	1.247HisVal: 1.247 ± 0.034	0.246HisTrp: 0.246 ± 0.013	0.634HisTyr: 0.634 ± 0.02	0.0HisXaa: 0.0 ± 0.0
Ile	5.574IleAla: 5.574 ± 0.056	0.989IleCys: 0.989 ± 0.027	4.138IleAsp: 4.138 ± 0.053	4.28IleGlu: 4.28 ± 0.057	3.126IlePhe: 3.126 ± 0.044	4.544IleGly: 4.544 ± 0.06	1.596IleHis: 1.596 ± 0.034	4.77IleIle: 4.77 ± 0.064	4.418IleLys: 4.418 ± 0.057	7.09IleLeu: 7.09 ± 0.08	1.784IleMet: 1.784 ± 0.033	3.132IleAsn: 3.132 ± 0.045	3.555IlePro: 3.555 ± 0.051	2.54IleGln: 2.54 ± 0.04	3.537IleArg: 3.537 ± 0.051	4.771IleSer: 4.771 ± 0.059	4.144IleThr: 4.144 ± 0.052	4.581IleVal: 4.581 ± 0.062	0.565IleTrp: 0.565 ± 0.018	1.8IleTyr: 1.8 ± 0.032	0.0IleXaa: 0.0 ± 0.0
Lys	5.005LysAla: 5.005 ± 0.059	0.48LysCys: 0.48 ± 0.017	3.285LysAsp: 3.285 ± 0.048	4.069LysGlu: 4.069 ± 0.058	1.845LysPhe: 1.845 ± 0.031	4.492LysGly: 4.492 ± 0.056	0.958LysHis: 0.958 ± 0.024	4.852LysIle: 4.852 ± 0.067	5.205LysLys: 5.205 ± 0.07	4.408LysLeu: 4.408 ± 0.059	1.622LysMet: 1.622 ± 0.037	3.07LysAsn: 3.07 ± 0.047	2.378LysPro: 2.378 ± 0.04	2.296LysGln: 2.296 ± 0.038	3.302LysArg: 3.302 ± 0.055	3.321LysSer: 3.321 ± 0.047	3.949LysThr: 3.949 ± 0.045	3.48LysVal: 3.48 ± 0.051	0.53LysTrp: 0.53 ± 0.021	1.456LysTyr: 1.456 ± 0.036	0.0LysXaa: 0.0 ± 0.0
Leu	8.76LeuAla: 8.76 ± 0.084	1.397LeuCys: 1.397 ± 0.029	5.846LeuAsp: 5.846 ± 0.055	6.446LeuGlu: 6.446 ± 0.071	4.992LeuPhe: 4.992 ± 0.08	7.418LeuGly: 7.418 ± 0.078	1.654LeuHis: 1.654 ± 0.029	6.177LeuIle: 6.177 ± 0.075	6.684LeuLys: 6.684 ± 0.075	9.039LeuLeu: 9.039 ± 0.098	2.735LeuMet: 2.735 ± 0.049	4.044LeuAsn: 4.044 ± 0.05	4.55LeuPro: 4.55 ± 0.056	2.475LeuGln: 2.475 ± 0.039	4.075LeuArg: 4.075 ± 0.054	6.756LeuSer: 6.756 ± 0.069	5.6LeuThr: 5.6 ± 0.061	7.229LeuVal: 7.229 ± 0.086	0.949LeuTrp: 0.949 ± 0.028	2.57LeuTyr: 2.57 ± 0.039	0.0LeuXaa: 0.0 ± 0.0
Met	3.154MetAla: 3.154 ± 0.045	0.254MetCys: 0.254 ± 0.014	2.137MetAsp: 2.137 ± 0.041	2.149MetGlu: 2.149 ± 0.039	0.911MetPhe: 0.911 ± 0.023	2.718MetGly: 2.718 ± 0.045	0.415MetHis: 0.415 ± 0.015	2.013MetIle: 2.013 ± 0.042	1.801MetLys: 1.801 ± 0.033	2.362MetLeu: 2.362 ± 0.041	0.768MetMet: 0.768 ± 0.025	1.259MetAsn: 1.259 ± 0.026	1.24MetPro: 1.24 ± 0.028	0.758MetGln: 0.758 ± 0.017	1.042MetArg: 1.042 ± 0.025	1.349MetSer: 1.349 ± 0.03	1.818MetThr: 1.818 ± 0.039	2.424MetVal: 2.424 ± 0.036	0.177MetTrp: 0.177 ± 0.011	0.475MetTyr: 0.475 ± 0.017	0.0MetXaa: 0.0 ± 0.0
Asn	2.877AsnAla: 2.877 ± 0.037	0.518AsnCys: 0.518 ± 0.018	1.96AsnAsp: 1.96 ± 0.034	2.017AsnGlu: 2.017 ± 0.038	1.678AsnPhe: 1.678 ± 0.031	2.725AsnGly: 2.725 ± 0.042	1.029AsnHis: 1.029 ± 0.026	2.948AsnIle: 2.948 ± 0.04	2.003AsnLys: 2.003 ± 0.043	4.184AsnLeu: 4.184 ± 0.055	1.009AsnMet: 1.009 ± 0.026	1.645AsnAsn: 1.645 ± 0.031	2.395AsnPro: 2.395 ± 0.039	1.614AsnGln: 1.614 ± 0.03	2.471AsnArg: 2.471 ± 0.042	2.113AsnSer: 2.113 ± 0.037	2.096AsnThr: 2.096 ± 0.037	2.189AsnVal: 2.189 ± 0.039	0.431AsnTrp: 0.431 ± 0.017	1.132AsnTyr: 1.132 ± 0.028	0.0AsnXaa: 0.0 ± 0.0
Pro	3.271ProAla: 3.271 ± 0.046	0.607ProCys: 0.607 ± 0.021	3.214ProAsp: 3.214 ± 0.047	3.612ProGlu: 3.612 ± 0.047	2.181ProPhe: 2.181 ± 0.038	4.225ProGly: 4.225 ± 0.058	0.895ProHis: 0.895 ± 0.023	2.308ProIle: 2.308 ± 0.041	2.014ProLys: 2.014 ± 0.037	4.349ProLeu: 4.349 ± 0.054	1.336ProMet: 1.336 ± 0.03	1.223ProAsn: 1.223 ± 0.029	1.785ProPro: 1.785 ± 0.035	1.351ProGln: 1.351 ± 0.033	1.917ProArg: 1.917 ± 0.035	2.322ProSer: 2.322 ± 0.041	1.853ProThr: 1.853 ± 0.035	3.743ProVal: 3.743 ± 0.053	0.58ProTrp: 0.58 ± 0.02	1.135ProTyr: 1.135 ± 0.03	0.0ProXaa: 0.0 ± 0.0
Gln	3.21GlnAla: 3.21 ± 0.047	0.345GlnCys: 0.345 ± 0.015	1.72GlnAsp: 1.72 ± 0.03	2.322GlnGlu: 2.322 ± 0.046	1.212GlnPhe: 1.212 ± 0.027	2.925GlnGly: 2.925 ± 0.038	0.528GlnHis: 0.528 ± 0.02	2.504GlnIle: 2.504 ± 0.037	2.35GlnLys: 2.35 ± 0.033	2.744GlnLeu: 2.744 ± 0.042	1.045GlnMet: 1.045 ± 0.025	1.351GlnAsn: 1.351 ± 0.034	1.208GlnPro: 1.208 ± 0.031	1.302GlnGln: 1.302 ± 0.027	2.026GlnArg: 2.026 ± 0.044	1.75GlnSer: 1.75 ± 0.036	2.152GlnThr: 2.152 ± 0.038	2.445GlnVal: 2.445 ± 0.038	0.446GlnTrp: 0.446 ± 0.016	0.91GlnTyr: 0.91 ± 0.024	0.0GlnXaa: 0.0 ± 0.0
Arg	3.824ArgAla: 3.824 ± 0.048	0.669ArgCys: 0.669 ± 0.02	2.631ArgAsp: 2.631 ± 0.04	3.308ArgGlu: 3.308 ± 0.049	2.697ArgPhe: 2.697 ± 0.038	3.187ArgGly: 3.187 ± 0.051	1.177ArgHis: 1.177 ± 0.03	4.11ArgIle: 4.11 ± 0.048	2.992ArgLys: 2.992 ± 0.044	5.529ArgLeu: 5.529 ± 0.066	1.591ArgMet: 1.591 ± 0.033	1.899ArgAsn: 1.899 ± 0.038	2.047ArgPro: 2.047 ± 0.038	2.171ArgGln: 2.171 ± 0.04	2.663ArgArg: 2.663 ± 0.049	2.891ArgSer: 2.891 ± 0.045	2.672ArgThr: 2.672 ± 0.042	3.728ArgVal: 3.728 ± 0.043	0.552ArgTrp: 0.552 ± 0.019	1.733ArgTyr: 1.733 ± 0.028	0.0ArgXaa: 0.0 ± 0.0
Ser	4.33SerAla: 4.33 ± 0.049	0.752SerCys: 0.752 ± 0.024	3.158SerAsp: 3.158 ± 0.044	3.015SerGlu: 3.015 ± 0.046	2.924SerPhe: 2.924 ± 0.044	4.972SerGly: 4.972 ± 0.061	1.3SerHis: 1.3 ± 0.029	4.157SerIle: 4.157 ± 0.052	2.998SerLys: 2.998 ± 0.049	6.232SerLeu: 6.232 ± 0.068	1.791SerMet: 1.791 ± 0.032	2.012SerAsn: 2.012 ± 0.039	2.772SerPro: 2.772 ± 0.039	2.05SerGln: 2.05 ± 0.037	3.356SerArg: 3.356 ± 0.048	3.611SerSer: 3.611 ± 0.062	3.096SerThr: 3.096 ± 0.048	3.834SerVal: 3.834 ± 0.048	0.739SerTrp: 0.739 ± 0.022	1.524SerTyr: 1.524 ± 0.032	0.0SerXaa: 0.0 ± 0.0
Thr	4.761ThrAla: 4.761 ± 0.062	0.725ThrCys: 0.725 ± 0.021	3.075ThrAsp: 3.075 ± 0.049	2.57ThrGlu: 2.57 ± 0.046	2.406ThrPhe: 2.406 ± 0.043	5.145ThrGly: 5.145 ± 0.053	1.233ThrHis: 1.233 ± 0.029	4.198ThrIle: 4.198 ± 0.057	2.209ThrLys: 2.209 ± 0.046	6.538ThrLeu: 6.538 ± 0.062	1.559ThrMet: 1.559 ± 0.031	1.754ThrAsn: 1.754 ± 0.035	3.114ThrPro: 3.114 ± 0.048	1.763ThrGln: 1.763 ± 0.033	3.123ThrArg: 3.123 ± 0.048	2.878ThrSer: 2.878 ± 0.046	3.159ThrThr: 3.159 ± 0.047	3.846ThrVal: 3.846 ± 0.049	0.591ThrTrp: 0.591 ± 0.019	1.447ThrTyr: 1.447 ± 0.031	0.0ThrXaa: 0.0 ± 0.0
Val	5.532ValAla: 5.532 ± 0.06	1.042ValCys: 1.042 ± 0.025	4.057ValAsp: 4.057 ± 0.05	4.326ValGlu: 4.326 ± 0.053	3.375ValPhe: 3.375 ± 0.047	4.218ValGly: 4.218 ± 0.06	1.366ValHis: 1.366 ± 0.029	4.613ValIle: 4.613 ± 0.059	4.047ValLys: 4.047 ± 0.051	6.707ValLeu: 6.707 ± 0.071	1.964ValMet: 1.964 ± 0.043	2.661ValAsn: 2.661 ± 0.04	2.898ValPro: 2.898 ± 0.045	2.084ValGln: 2.084 ± 0.036	3.17ValArg: 3.17 ± 0.045	4.369ValSer: 4.369 ± 0.051	3.888ValThr: 3.888 ± 0.053	5.33ValVal: 5.33 ± 0.07	0.689ValTrp: 0.689 ± 0.021	1.807ValTyr: 1.807 ± 0.035	0.0ValXaa: 0.0 ± 0.0
Trp	0.747TrpAla: 0.747 ± 0.025	0.139TrpCys: 0.139 ± 0.01	0.56TrpAsp: 0.56 ± 0.02	0.642TrpGlu: 0.642 ± 0.021	0.529TrpPhe: 0.529 ± 0.021	0.75TrpGly: 0.75 ± 0.023	0.233TrpHis: 0.233 ± 0.012	0.799TrpIle: 0.799 ± 0.023	0.673TrpLys: 0.673 ± 0.024	1.061TrpLeu: 1.061 ± 0.027	0.314TrpMet: 0.314 ± 0.013	0.479TrpAsn: 0.479 ± 0.018	0.428TrpPro: 0.428 ± 0.017	0.508TrpGln: 0.508 ± 0.019	0.506TrpArg: 0.506 ± 0.019	0.547TrpSer: 0.547 ± 0.018	0.531TrpThr: 0.531 ± 0.022	0.704TrpVal: 0.704 ± 0.023	0.133TrpTrp: 0.133 ± 0.011	0.305TrpTyr: 0.305 ± 0.015	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.996TyrAla: 1.996 ± 0.034	0.417TyrCys: 0.417 ± 0.015	1.588TyrAsp: 1.588 ± 0.035	1.505TyrGlu: 1.505 ± 0.034	1.466TyrPhe: 1.466 ± 0.029	2.102TyrGly: 2.102 ± 0.038	0.671TyrHis: 0.671 ± 0.02	1.599TyrIle: 1.599 ± 0.037	1.387TyrLys: 1.387 ± 0.03	2.99TyrLeu: 2.99 ± 0.042	0.692TyrMet: 0.692 ± 0.021	1.1TyrAsn: 1.1 ± 0.026	1.348TyrPro: 1.348 ± 0.032	1.037TyrGln: 1.037 ± 0.024	1.689TyrArg: 1.689 ± 0.031	1.725TyrSer: 1.725 ± 0.035	1.625TyrThr: 1.625 ± 0.036	1.557TyrVal: 1.557 ± 0.033	0.33TyrTrp: 0.33 ± 0.015	0.976TyrTyr: 0.976 ± 0.023	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4846 proteins (1634900 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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