Amino acid dipepetide frequency for Ectothiorhodospira haloalkaliphila

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	11.17AlaAla: 11.17 ± 0.145	1.168AlaCys: 1.168 ± 0.034	5.696AlaAsp: 5.696 ± 0.08	6.438AlaGlu: 6.438 ± 0.097	3.557AlaPhe: 3.557 ± 0.065	8.767AlaGly: 8.767 ± 0.105	2.583AlaHis: 2.583 ± 0.064	4.605AlaIle: 4.605 ± 0.074	2.233AlaLys: 2.233 ± 0.063	12.612AlaLeu: 12.612 ± 0.156	3.124AlaMet: 3.124 ± 0.063	2.254AlaAsn: 2.254 ± 0.051	4.554AlaPro: 4.554 ± 0.082	4.367AlaGln: 4.367 ± 0.079	9.142AlaArg: 9.142 ± 0.116	5.077AlaSer: 5.077 ± 0.079	4.611AlaThr: 4.611 ± 0.055	7.417AlaVal: 7.417 ± 0.085	1.693AlaTrp: 1.693 ± 0.052	2.221AlaTyr: 2.221 ± 0.051	0.001AlaXaa: 0.001 ± 0.001
Cys	0.849CysAla: 0.849 ± 0.032	0.114CysCys: 0.114 ± 0.012	0.553CysAsp: 0.553 ± 0.027	0.51CysGlu: 0.51 ± 0.023	0.313CysPhe: 0.313 ± 0.019	0.942CysGly: 0.942 ± 0.031	0.368CysHis: 0.368 ± 0.025	0.38CysIle: 0.38 ± 0.019	0.208CysLys: 0.208 ± 0.015	1.078CysLeu: 1.078 ± 0.035	0.215CysMet: 0.215 ± 0.015	0.232CysAsn: 0.232 ± 0.018	0.579CysPro: 0.579 ± 0.03	0.402CysGln: 0.402 ± 0.019	0.783CysArg: 0.783 ± 0.031	0.457CysSer: 0.457 ± 0.021	0.403CysThr: 0.403 ± 0.019	0.625CysVal: 0.625 ± 0.028	0.118CysTrp: 0.118 ± 0.011	0.194CysTyr: 0.194 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	6.023AspAla: 6.023 ± 0.081	0.538AspCys: 0.538 ± 0.027	3.669AspAsp: 3.669 ± 0.068	4.178AspGlu: 4.178 ± 0.071	2.184AspPhe: 2.184 ± 0.049	4.61AspGly: 4.61 ± 0.072	1.68AspHis: 1.68 ± 0.039	2.666AspIle: 2.666 ± 0.055	1.544AspLys: 1.544 ± 0.052	6.727AspLeu: 6.727 ± 0.092	1.568AspMet: 1.568 ± 0.043	1.452AspAsn: 1.452 ± 0.044	3.728AspPro: 3.728 ± 0.057	2.422AspGln: 2.422 ± 0.051	4.605AspArg: 4.605 ± 0.07	2.583AspSer: 2.583 ± 0.058	3.095AspThr: 3.095 ± 0.063	4.046AspVal: 4.046 ± 0.067	1.066AspTrp: 1.066 ± 0.033	1.682AspTyr: 1.682 ± 0.045	0.0AspXaa: 0.0 ± 0.0
Glu	8.04GluAla: 8.04 ± 0.117	0.429GluCys: 0.429 ± 0.02	3.836GluAsp: 3.836 ± 0.075	4.112GluGlu: 4.112 ± 0.086	1.915GluPhe: 1.915 ± 0.049	5.275GluGly: 5.275 ± 0.074	1.76GluHis: 1.76 ± 0.049	2.967GluIle: 2.967 ± 0.067	1.96GluLys: 1.96 ± 0.063	6.425GluLeu: 6.425 ± 0.094	1.705GluMet: 1.705 ± 0.046	1.586GluAsn: 1.586 ± 0.047	3.264GluPro: 3.264 ± 0.082	3.625GluGln: 3.625 ± 0.066	5.984GluArg: 5.984 ± 0.105	3.269GluSer: 3.269 ± 0.06	3.231GluThr: 3.231 ± 0.067	4.691GluVal: 4.691 ± 0.071	0.843GluTrp: 0.843 ± 0.033	1.36GluTyr: 1.36 ± 0.037	0.001GluXaa: 0.001 ± 0.001
Phe	3.176PheAla: 3.176 ± 0.065	0.38PheCys: 0.38 ± 0.021	2.247PheAsp: 2.247 ± 0.045	2.323PheGlu: 2.323 ± 0.058	1.265PhePhe: 1.265 ± 0.044	2.93PheGly: 2.93 ± 0.071	0.893PheHis: 0.893 ± 0.035	1.509PheIle: 1.509 ± 0.052	0.944PheLys: 0.944 ± 0.034	3.306PheLeu: 3.306 ± 0.066	0.889PheMet: 0.889 ± 0.036	1.101PheAsn: 1.101 ± 0.038	1.477PhePro: 1.477 ± 0.044	1.248PheGln: 1.248 ± 0.041	2.28PheArg: 2.28 ± 0.048	2.039PheSer: 2.039 ± 0.048	1.904PheThr: 1.904 ± 0.044	2.369PheVal: 2.369 ± 0.05	0.503PheTrp: 0.503 ± 0.027	0.907PheTyr: 0.907 ± 0.034	0.0PheXaa: 0.0 ± 0.0
Gly	7.256GlyAla: 7.256 ± 0.097	0.975GlyCys: 0.975 ± 0.032	4.702GlyAsp: 4.702 ± 0.058	5.458GlyGlu: 5.458 ± 0.079	3.141GlyPhe: 3.141 ± 0.062	6.47GlyGly: 6.47 ± 0.115	2.262GlyHis: 2.262 ± 0.053	4.06GlyIle: 4.06 ± 0.071	2.529GlyLys: 2.529 ± 0.064	9.465GlyLeu: 9.465 ± 0.12	2.586GlyMet: 2.586 ± 0.059	2.031GlyAsn: 2.031 ± 0.046	3.307GlyPro: 3.307 ± 0.065	3.592GlyGln: 3.592 ± 0.068	6.477GlyArg: 6.477 ± 0.109	4.109GlySer: 4.109 ± 0.065	3.935GlyThr: 3.935 ± 0.07	6.429GlyVal: 6.429 ± 0.098	1.323GlyTrp: 1.323 ± 0.047	2.271GlyTyr: 2.271 ± 0.053	0.001GlyXaa: 0.001 ± 0.001
His	2.52HisAla: 2.52 ± 0.048	0.339HisCys: 0.339 ± 0.02	1.524HisAsp: 1.524 ± 0.045	1.534HisGlu: 1.534 ± 0.042	0.968HisPhe: 0.968 ± 0.036	2.28HisGly: 2.28 ± 0.052	0.927HisHis: 0.927 ± 0.037	1.009HisIle: 1.009 ± 0.03	0.544HisLys: 0.544 ± 0.024	3.076HisLeu: 3.076 ± 0.053	0.606HisMet: 0.606 ± 0.024	0.535HisAsn: 0.535 ± 0.021	1.897HisPro: 1.897 ± 0.047	1.085HisGln: 1.085 ± 0.036	2.074HisArg: 2.074 ± 0.052	1.078HisSer: 1.078 ± 0.036	1.22HisThr: 1.22 ± 0.034	1.823HisVal: 1.823 ± 0.044	0.548HisTrp: 0.548 ± 0.025	0.805HisTyr: 0.805 ± 0.03	0.0HisXaa: 0.0 ± 0.0
Ile	4.472IleAla: 4.472 ± 0.082	0.447IleCys: 0.447 ± 0.023	2.586IleAsp: 2.586 ± 0.053	2.965IleGlu: 2.965 ± 0.067	1.349IlePhe: 1.349 ± 0.042	3.571IleGly: 3.571 ± 0.062	1.375IleHis: 1.375 ± 0.039	2.219IleIle: 2.219 ± 0.064	1.318IleLys: 1.318 ± 0.041	4.674IleLeu: 4.674 ± 0.086	1.008IleMet: 1.008 ± 0.037	1.506IleAsn: 1.506 ± 0.044	2.503IlePro: 2.503 ± 0.048	1.904IleGln: 1.904 ± 0.044	3.648IleArg: 3.648 ± 0.056	2.627IleSer: 2.627 ± 0.055	2.775IleThr: 2.775 ± 0.054	2.732IleVal: 2.732 ± 0.059	0.511IleTrp: 0.511 ± 0.024	1.037IleTyr: 1.037 ± 0.033	0.0IleXaa: 0.0 ± 0.0
Lys	3.273LysAla: 3.273 ± 0.071	0.142LysCys: 0.142 ± 0.013	1.652LysAsp: 1.652 ± 0.05	1.635LysGlu: 1.635 ± 0.051	0.558LysPhe: 0.558 ± 0.028	2.262LysGly: 2.262 ± 0.062	0.626LysHis: 0.626 ± 0.023	1.08LysIle: 1.08 ± 0.038	0.959LysLys: 0.959 ± 0.043	2.453LysLeu: 2.453 ± 0.068	0.559LysMet: 0.559 ± 0.026	0.68LysAsn: 0.68 ± 0.03	1.614LysPro: 1.614 ± 0.046	1.043LysGln: 1.043 ± 0.035	2.079LysArg: 2.079 ± 0.056	1.354LysSer: 1.354 ± 0.04	1.417LysThr: 1.417 ± 0.043	2.041LysVal: 2.041 ± 0.057	0.241LysTrp: 0.241 ± 0.017	0.51LysTyr: 0.51 ± 0.023	0.0LysXaa: 0.0 ± 0.0
Leu	12.363LeuAla: 12.363 ± 0.148	0.997LeuCys: 0.997 ± 0.037	7.042LeuAsp: 7.042 ± 0.098	8.1LeuGlu: 8.1 ± 0.119	3.679LeuPhe: 3.679 ± 0.07	8.973LeuGly: 8.973 ± 0.111	2.499LeuHis: 2.499 ± 0.05	4.967LeuIle: 4.967 ± 0.076	3.47LeuLys: 3.47 ± 0.063	11.345LeuLeu: 11.345 ± 0.184	2.905LeuMet: 2.905 ± 0.06	2.872LeuAsn: 2.872 ± 0.057	6.031LeuPro: 6.031 ± 0.087	3.949LeuGln: 3.949 ± 0.071	8.156LeuArg: 8.156 ± 0.108	6.195LeuSer: 6.195 ± 0.091	5.518LeuThr: 5.518 ± 0.08	7.831LeuVal: 7.831 ± 0.104	1.413LeuTrp: 1.413 ± 0.042	2.194LeuTyr: 2.194 ± 0.053	0.001LeuXaa: 0.001 ± 0.001
Met	3.046MetAla: 3.046 ± 0.055	0.145MetCys: 0.145 ± 0.011	1.736MetAsp: 1.736 ± 0.044	1.776MetGlu: 1.776 ± 0.047	0.594MetPhe: 0.594 ± 0.025	2.236MetGly: 2.236 ± 0.052	0.554MetHis: 0.554 ± 0.025	1.198MetIle: 1.198 ± 0.039	0.924MetLys: 0.924 ± 0.035	2.648MetLeu: 2.648 ± 0.05	0.685MetMet: 0.685 ± 0.028	0.908MetAsn: 0.908 ± 0.03	1.552MetPro: 1.552 ± 0.041	1.05MetGln: 1.05 ± 0.033	1.791MetArg: 1.791 ± 0.051	1.572MetSer: 1.572 ± 0.043	1.57MetThr: 1.57 ± 0.046	1.9MetVal: 1.9 ± 0.054	0.183MetTrp: 0.183 ± 0.014	0.395MetTyr: 0.395 ± 0.02	0.0MetXaa: 0.0 ± 0.0
Asn	2.525AsnAla: 2.525 ± 0.056	0.224AsnCys: 0.224 ± 0.018	1.434AsnAsp: 1.434 ± 0.041	1.415AsnGlu: 1.415 ± 0.044	0.768AsnPhe: 0.768 ± 0.034	1.811AsnGly: 1.811 ± 0.048	0.659AsnHis: 0.659 ± 0.027	1.26AsnIle: 1.26 ± 0.039	0.588AsnLys: 0.588 ± 0.027	2.976AsnLeu: 2.976 ± 0.061	0.6AsnMet: 0.6 ± 0.03	0.637AsnAsn: 0.637 ± 0.027	1.897AsnPro: 1.897 ± 0.047	1.038AsnGln: 1.038 ± 0.036	2.059AsnArg: 2.059 ± 0.06	1.01AsnSer: 1.01 ± 0.046	1.408AsnThr: 1.408 ± 0.042	1.751AsnVal: 1.751 ± 0.054	0.349AsnTrp: 0.349 ± 0.019	0.6AsnTyr: 0.6 ± 0.03	0.0AsnXaa: 0.0 ± 0.0
Pro	5.261ProAla: 5.261 ± 0.087	0.412ProCys: 0.412 ± 0.023	3.914ProAsp: 3.914 ± 0.075	4.66ProGlu: 4.66 ± 0.081	1.704ProPhe: 1.704 ± 0.043	4.936ProGly: 4.936 ± 0.08	1.366ProHis: 1.366 ± 0.041	2.056ProIle: 2.056 ± 0.049	1.17ProLys: 1.17 ± 0.045	5.244ProLeu: 5.244 ± 0.087	1.407ProMet: 1.407 ± 0.036	1.065ProAsn: 1.065 ± 0.035	2.774ProPro: 2.774 ± 0.066	1.835ProGln: 1.835 ± 0.047	3.641ProArg: 3.641 ± 0.065	2.528ProSer: 2.528 ± 0.059	2.318ProThr: 2.318 ± 0.048	4.318ProVal: 4.318 ± 0.075	0.828ProTrp: 0.828 ± 0.032	1.125ProTyr: 1.125 ± 0.034	0.0ProXaa: 0.0 ± 0.0
Gln	5.472GlnAla: 5.472 ± 0.103	0.344GlnCys: 0.344 ± 0.02	2.248GlnAsp: 2.248 ± 0.052	2.573GlnGlu: 2.573 ± 0.055	1.158GlnPhe: 1.158 ± 0.04	3.838GlnGly: 3.838 ± 0.067	0.93GlnHis: 0.93 ± 0.036	1.716GlnIle: 1.716 ± 0.043	0.919GlnLys: 0.919 ± 0.036	3.744GlnLeu: 3.744 ± 0.06	0.952GlnMet: 0.952 ± 0.032	0.851GlnAsn: 0.851 ± 0.031	2.167GlnPro: 2.167 ± 0.058	1.954GlnGln: 1.954 ± 0.052	3.47GlnArg: 3.47 ± 0.07	2.036GlnSer: 2.036 ± 0.054	1.93GlnThr: 1.93 ± 0.048	3.854GlnVal: 3.854 ± 0.066	0.681GlnTrp: 0.681 ± 0.026	0.859GlnTyr: 0.859 ± 0.031	0.0GlnXaa: 0.0 ± 0.0
Arg	7.325ArgAla: 7.325 ± 0.093	0.676ArgCys: 0.676 ± 0.023	4.756ArgAsp: 4.756 ± 0.076	5.844ArgGlu: 5.844 ± 0.095	3.232ArgPhe: 3.232 ± 0.054	5.357ArgGly: 5.357 ± 0.09	2.44ArgHis: 2.44 ± 0.057	4.082ArgIle: 4.082 ± 0.071	2.009ArgLys: 2.009 ± 0.054	9.548ArgLeu: 9.548 ± 0.112	2.207ArgMet: 2.207 ± 0.051	1.88ArgAsn: 1.88 ± 0.044	3.747ArgPro: 3.747 ± 0.074	3.772ArgGln: 3.772 ± 0.08	6.497ArgArg: 6.497 ± 0.098	3.693ArgSer: 3.693 ± 0.071	3.19ArgThr: 3.19 ± 0.072	6.051ArgVal: 6.051 ± 0.095	1.259ArgTrp: 1.259 ± 0.04	2.162ArgTyr: 2.162 ± 0.052	0.002ArgXaa: 0.002 ± 0.001
Ser	4.844SerAla: 4.844 ± 0.082	0.424SerCys: 0.424 ± 0.026	2.825SerAsp: 2.825 ± 0.055	2.955SerGlu: 2.955 ± 0.055	1.704SerPhe: 1.704 ± 0.047	5.008SerGly: 5.008 ± 0.078	1.355SerHis: 1.355 ± 0.04	2.246SerIle: 2.246 ± 0.055	1.107SerLys: 1.107 ± 0.035	5.907SerLeu: 5.907 ± 0.085	1.437SerMet: 1.437 ± 0.042	1.223SerAsn: 1.223 ± 0.048	2.807SerPro: 2.807 ± 0.059	2.042SerGln: 2.042 ± 0.047	4.262SerArg: 4.262 ± 0.066	2.678SerSer: 2.678 ± 0.062	2.529SerThr: 2.529 ± 0.051	3.602SerVal: 3.602 ± 0.067	0.62SerTrp: 0.62 ± 0.028	1.136SerTyr: 1.136 ± 0.038	0.0SerXaa: 0.0 ± 0.0
Thr	4.739ThrAla: 4.739 ± 0.068	0.468ThrCys: 0.468 ± 0.025	2.748ThrAsp: 2.748 ± 0.053	2.632ThrGlu: 2.632 ± 0.061	1.521ThrPhe: 1.521 ± 0.043	4.716ThrGly: 4.716 ± 0.081	1.339ThrHis: 1.339 ± 0.041	1.902ThrIle: 1.902 ± 0.051	0.818ThrLys: 0.818 ± 0.03	6.72ThrLeu: 6.72 ± 0.091	0.944ThrMet: 0.944 ± 0.036	1.023ThrAsn: 1.023 ± 0.036	3.316ThrPro: 3.316 ± 0.057	1.988ThrGln: 1.988 ± 0.045	4.023ThrArg: 4.023 ± 0.064	2.279ThrSer: 2.279 ± 0.055	2.432ThrThr: 2.432 ± 0.058	3.766ThrVal: 3.766 ± 0.069	0.663ThrTrp: 0.663 ± 0.03	1.111ThrTyr: 1.111 ± 0.044	0.002ThrXaa: 0.002 ± 0.002
Val	7.708ValAla: 7.708 ± 0.108	0.716ValCys: 0.716 ± 0.026	4.891ValAsp: 4.891 ± 0.072	5.055ValGlu: 5.055 ± 0.077	2.625ValPhe: 2.625 ± 0.056	5.535ValGly: 5.535 ± 0.088	1.752ValHis: 1.752 ± 0.045	3.854ValIle: 3.854 ± 0.077	2.031ValLys: 2.031 ± 0.058	7.772ValLeu: 7.772 ± 0.116	2.133ValMet: 2.133 ± 0.056	2.188ValAsn: 2.188 ± 0.058	3.403ValPro: 3.403 ± 0.073	2.503ValGln: 2.503 ± 0.053	5.239ValArg: 5.239 ± 0.083	4.212ValSer: 4.212 ± 0.066	3.9ValThr: 3.9 ± 0.071	5.946ValVal: 5.946 ± 0.099	0.851ValTrp: 0.851 ± 0.031	1.52ValTyr: 1.52 ± 0.041	0.0ValXaa: 0.0 ± 0.0
Trp	1.149TrpAla: 1.149 ± 0.039	0.141TrpCys: 0.141 ± 0.011	0.716TrpAsp: 0.716 ± 0.03	0.822TrpGlu: 0.822 ± 0.03	0.543TrpPhe: 0.543 ± 0.024	0.976TrpGly: 0.976 ± 0.034	0.373TrpHis: 0.373 ± 0.023	0.636TrpIle: 0.636 ± 0.027	0.357TrpLys: 0.357 ± 0.019	2.029TrpLeu: 2.029 ± 0.063	0.435TrpMet: 0.435 ± 0.021	0.37TrpAsn: 0.37 ± 0.02	0.702TrpPro: 0.702 ± 0.028	0.778TrpGln: 0.778 ± 0.029	1.236TrpArg: 1.236 ± 0.043	0.791TrpSer: 0.791 ± 0.028	0.615TrpThr: 0.615 ± 0.024	1.09TrpVal: 1.09 ± 0.036	0.267TrpTrp: 0.267 ± 0.019	0.361TrpTyr: 0.361 ± 0.021	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.08TyrAla: 2.08 ± 0.051	0.244TyrCys: 0.244 ± 0.016	1.29TyrAsp: 1.29 ± 0.039	1.292TyrGlu: 1.292 ± 0.035	0.912TyrPhe: 0.912 ± 0.034	1.88TyrGly: 1.88 ± 0.051	0.651TyrHis: 0.651 ± 0.027	0.814TyrIle: 0.814 ± 0.028	0.546TyrLys: 0.546 ± 0.027	2.753TyrLeu: 2.753 ± 0.053	0.497TyrMet: 0.497 ± 0.026	0.615TyrAsn: 0.615 ± 0.021	1.241TyrPro: 1.241 ± 0.037	1.1TyrGln: 1.1 ± 0.031	2.284TyrArg: 2.284 ± 0.051	1.122TyrSer: 1.122 ± 0.04	1.148TyrThr: 1.148 ± 0.032	1.554TyrVal: 1.554 ± 0.037	0.427TyrTrp: 0.427 ± 0.02	0.672TyrTyr: 0.672 ± 0.034	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.001XaaGlu: 0.001 ± 0.001	0.001XaaPhe: 0.001 ± 0.001	0.001XaaGly: 0.001 ± 0.001	0.0XaaHis: 0.0 ± 0.0	0.001XaaIle: 0.001 ± 0.001	0.0XaaLys: 0.0 ± 0.0	0.001XaaLeu: 0.001 ± 0.001	0.0XaaMet: 0.0 ± 0.0	0.001XaaAsn: 0.001 ± 0.001	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.001XaaSer: 0.001 ± 0.001	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.001XaaTyr: 0.001 ± 0.001	0.002XaaXaa: 0.002 ± 0.001

Statistics based on 2964 proteins (929654 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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