Amino acid dipepetide frequency for Streptococcus phage Javan291

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.6AlaAla: 3.6 ± 1.239
0.251AlaCys: 0.251 ± 0.154
4.102AlaAsp: 4.102 ± 0.496
8.371AlaGlu: 8.371 ± 0.833
3.6AlaPhe: 3.6 ± 1.106
5.692AlaGly: 5.692 ± 0.939
0.586AlaHis: 0.586 ± 0.213
5.525AlaIle: 5.525 ± 1.1
5.692AlaLys: 5.692 ± 0.679
8.622AlaLeu: 8.622 ± 1.1
2.595AlaMet: 2.595 ± 0.514
3.432AlaAsn: 3.432 ± 0.465
2.344AlaPro: 2.344 ± 0.629
3.348AlaGln: 3.348 ± 0.634
3.181AlaArg: 3.181 ± 0.509
3.934AlaSer: 3.934 ± 1.038
3.432AlaThr: 3.432 ± 0.506
5.692AlaVal: 5.692 ± 1.053
0.419AlaTrp: 0.419 ± 0.166
1.59AlaTyr: 1.59 ± 0.37
0.0AlaXaa: 0.0 ± 0.0
Cys
0.502CysAla: 0.502 ± 0.201
0.0CysCys: 0.0 ± 0.0
0.335CysAsp: 0.335 ± 0.171
0.502CysGlu: 0.502 ± 0.189
0.419CysPhe: 0.419 ± 0.242
0.084CysGly: 0.084 ± 0.075
0.084CysHis: 0.084 ± 0.081
0.335CysIle: 0.335 ± 0.171
0.167CysLys: 0.167 ± 0.133
0.837CysLeu: 0.837 ± 0.241
0.0CysMet: 0.0 ± 0.0
0.167CysAsn: 0.167 ± 0.143
0.084CysPro: 0.084 ± 0.083
0.335CysGln: 0.335 ± 0.151
0.167CysArg: 0.167 ± 0.097
0.251CysSer: 0.251 ± 0.142
0.335CysThr: 0.335 ± 0.144
0.419CysVal: 0.419 ± 0.218
0.084CysTrp: 0.084 ± 0.094
0.167CysTyr: 0.167 ± 0.142
0.0CysXaa: 0.0 ± 0.0
Asp
2.93AspAla: 2.93 ± 0.462
0.251AspCys: 0.251 ± 0.174
3.851AspAsp: 3.851 ± 0.826
6.446AspGlu: 6.446 ± 0.801
4.186AspPhe: 4.186 ± 0.529
5.023AspGly: 5.023 ± 0.736
0.67AspHis: 0.67 ± 0.274
2.26AspIle: 2.26 ± 0.389
4.604AspLys: 4.604 ± 0.599
5.19AspLeu: 5.19 ± 0.748
1.423AspMet: 1.423 ± 0.333
3.6AspAsn: 3.6 ± 0.612
1.339AspPro: 1.339 ± 0.306
1.507AspGln: 1.507 ± 0.274
2.762AspArg: 2.762 ± 0.484
4.353AspSer: 4.353 ± 0.646
3.014AspThr: 3.014 ± 0.564
3.432AspVal: 3.432 ± 0.62
0.753AspTrp: 0.753 ± 0.205
2.26AspTyr: 2.26 ± 0.546
0.0AspXaa: 0.0 ± 0.0
Glu
5.609GluAla: 5.609 ± 0.635
0.335GluCys: 0.335 ± 0.173
4.52GluAsp: 4.52 ± 0.621
7.45GluGlu: 7.45 ± 1.156
3.181GluPhe: 3.181 ± 0.564
4.353GluGly: 4.353 ± 0.529
1.172GluHis: 1.172 ± 0.36
5.776GluIle: 5.776 ± 0.79
6.613GluLys: 6.613 ± 0.794
7.618GluLeu: 7.618 ± 0.799
3.181GluMet: 3.181 ± 0.54
4.604GluAsn: 4.604 ± 0.613
1.005GluPro: 1.005 ± 0.318
5.274GluGln: 5.274 ± 0.672
4.939GluArg: 4.939 ± 0.702
3.851GluSer: 3.851 ± 0.576
3.014GluThr: 3.014 ± 0.615
6.195GluVal: 6.195 ± 0.896
1.088GluTrp: 1.088 ± 0.333
2.595GluTyr: 2.595 ± 0.56
0.0GluXaa: 0.0 ± 0.0
Phe
2.846PheAla: 2.846 ± 0.382
0.335PheCys: 0.335 ± 0.206
2.846PheAsp: 2.846 ± 0.47
4.52PheGlu: 4.52 ± 0.645
1.256PhePhe: 1.256 ± 0.448
2.762PheGly: 2.762 ± 0.645
0.502PheHis: 0.502 ± 0.286
2.26PheIle: 2.26 ± 0.462
3.181PheLys: 3.181 ± 0.613
2.511PheLeu: 2.511 ± 0.446
0.753PheMet: 0.753 ± 0.257
2.176PheAsn: 2.176 ± 0.479
0.753PhePro: 0.753 ± 0.262
1.842PheGln: 1.842 ± 0.384
1.674PheArg: 1.674 ± 0.489
2.428PheSer: 2.428 ± 0.511
2.595PheThr: 2.595 ± 0.457
2.511PheVal: 2.511 ± 0.468
0.837PheTrp: 0.837 ± 0.3
1.925PheTyr: 1.925 ± 0.411
0.0PheXaa: 0.0 ± 0.0
Gly
4.688GlyAla: 4.688 ± 0.933
0.502GlyCys: 0.502 ± 0.188
3.934GlyAsp: 3.934 ± 0.712
4.939GlyGlu: 4.939 ± 0.82
3.516GlyPhe: 3.516 ± 0.608
3.097GlyGly: 3.097 ± 0.401
1.59GlyHis: 1.59 ± 0.372
6.195GlyIle: 6.195 ± 0.731
4.688GlyLys: 4.688 ± 0.706
5.86GlyLeu: 5.86 ± 0.7
2.26GlyMet: 2.26 ± 0.387
2.846GlyAsn: 2.846 ± 0.401
0.67GlyPro: 0.67 ± 0.304
3.014GlyGln: 3.014 ± 0.589
2.846GlyArg: 2.846 ± 0.514
3.432GlySer: 3.432 ± 0.662
4.52GlyThr: 4.52 ± 0.684
5.441GlyVal: 5.441 ± 0.882
0.586GlyTrp: 0.586 ± 0.196
2.176GlyTyr: 2.176 ± 0.433
0.0GlyXaa: 0.0 ± 0.0
His
0.837HisAla: 0.837 ± 0.234
0.251HisCys: 0.251 ± 0.152
0.586HisAsp: 0.586 ± 0.217
1.005HisGlu: 1.005 ± 0.279
0.67HisPhe: 0.67 ± 0.264
1.256HisGly: 1.256 ± 0.4
0.167HisHis: 0.167 ± 0.12
1.088HisIle: 1.088 ± 0.323
0.502HisLys: 0.502 ± 0.203
1.59HisLeu: 1.59 ± 0.355
0.084HisMet: 0.084 ± 0.082
0.502HisAsn: 0.502 ± 0.195
0.67HisPro: 0.67 ± 0.248
0.502HisGln: 0.502 ± 0.28
0.753HisArg: 0.753 ± 0.339
0.67HisSer: 0.67 ± 0.2
0.753HisThr: 0.753 ± 0.214
1.172HisVal: 1.172 ± 0.32
0.084HisTrp: 0.084 ± 0.078
0.921HisTyr: 0.921 ± 0.276
0.0HisXaa: 0.0 ± 0.0
Ile
5.692IleAla: 5.692 ± 0.659
0.586IleCys: 0.586 ± 0.215
5.525IleAsp: 5.525 ± 0.675
6.613IleGlu: 6.613 ± 0.703
1.005IlePhe: 1.005 ± 0.293
4.604IleGly: 4.604 ± 0.599
1.256IleHis: 1.256 ± 0.297
4.102IleIle: 4.102 ± 0.658
5.274IleLys: 5.274 ± 0.626
4.186IleLeu: 4.186 ± 0.598
0.502IleMet: 0.502 ± 0.192
3.097IleAsn: 3.097 ± 0.527
2.176IlePro: 2.176 ± 0.397
2.176IleGln: 2.176 ± 0.475
2.26IleArg: 2.26 ± 0.295
4.186IleSer: 4.186 ± 0.937
3.851IleThr: 3.851 ± 0.663
5.023IleVal: 5.023 ± 0.647
0.335IleTrp: 0.335 ± 0.192
2.176IleTyr: 2.176 ± 0.438
0.0IleXaa: 0.0 ± 0.0
Lys
6.027LysAla: 6.027 ± 0.838
0.335LysCys: 0.335 ± 0.152
3.767LysAsp: 3.767 ± 0.647
4.855LysGlu: 4.855 ± 0.766
2.344LysPhe: 2.344 ± 0.518
3.516LysGly: 3.516 ± 0.795
1.339LysHis: 1.339 ± 0.391
4.52LysIle: 4.52 ± 0.763
6.027LysLys: 6.027 ± 1.036
6.864LysLeu: 6.864 ± 0.853
2.344LysMet: 2.344 ± 0.483
4.186LysAsn: 4.186 ± 0.592
2.26LysPro: 2.26 ± 0.342
4.353LysGln: 4.353 ± 0.687
4.939LysArg: 4.939 ± 0.795
4.771LysSer: 4.771 ± 0.774
4.102LysThr: 4.102 ± 0.621
6.111LysVal: 6.111 ± 0.598
0.921LysTrp: 0.921 ± 0.265
3.181LysTyr: 3.181 ± 0.593
0.0LysXaa: 0.0 ± 0.0
Leu
8.12LeuAla: 8.12 ± 0.738
0.335LeuCys: 0.335 ± 0.149
6.529LeuAsp: 6.529 ± 0.706
7.366LeuGlu: 7.366 ± 0.806
3.348LeuPhe: 3.348 ± 0.493
5.776LeuGly: 5.776 ± 0.868
1.59LeuHis: 1.59 ± 0.371
4.353LeuIle: 4.353 ± 0.692
6.195LeuLys: 6.195 ± 0.749
5.357LeuLeu: 5.357 ± 0.726
1.005LeuMet: 1.005 ± 0.317
2.93LeuAsn: 2.93 ± 0.562
2.176LeuPro: 2.176 ± 0.56
3.767LeuGln: 3.767 ± 0.482
3.851LeuArg: 3.851 ± 0.61
6.864LeuSer: 6.864 ± 0.687
4.855LeuThr: 4.855 ± 0.6
4.855LeuVal: 4.855 ± 0.709
1.005LeuTrp: 1.005 ± 0.352
3.014LeuTyr: 3.014 ± 0.605
0.0LeuXaa: 0.0 ± 0.0
Met
2.595MetAla: 2.595 ± 0.701
0.084MetCys: 0.084 ± 0.081
1.339MetAsp: 1.339 ± 0.278
1.256MetGlu: 1.256 ± 0.346
0.67MetPhe: 0.67 ± 0.225
1.674MetGly: 1.674 ± 0.369
0.084MetHis: 0.084 ± 0.078
1.507MetIle: 1.507 ± 0.318
2.595MetLys: 2.595 ± 0.466
1.339MetLeu: 1.339 ± 0.381
0.586MetMet: 0.586 ± 0.221
1.507MetAsn: 1.507 ± 0.284
0.753MetPro: 0.753 ± 0.277
1.172MetGln: 1.172 ± 0.313
1.172MetArg: 1.172 ± 0.337
1.256MetSer: 1.256 ± 0.313
2.26MetThr: 2.26 ± 0.502
1.088MetVal: 1.088 ± 0.303
0.586MetTrp: 0.586 ± 0.171
0.502MetTyr: 0.502 ± 0.23
0.0MetXaa: 0.0 ± 0.0
Asn
3.432AsnAla: 3.432 ± 0.74
0.251AsnCys: 0.251 ± 0.133
2.511AsnAsp: 2.511 ± 0.489
3.181AsnGlu: 3.181 ± 0.675
2.009AsnPhe: 2.009 ± 0.342
4.353AsnGly: 4.353 ± 0.674
0.753AsnHis: 0.753 ± 0.19
2.428AsnIle: 2.428 ± 0.387
4.102AsnLys: 4.102 ± 0.613
3.348AsnLeu: 3.348 ± 0.581
0.419AsnMet: 0.419 ± 0.196
1.758AsnAsn: 1.758 ± 0.433
2.26AsnPro: 2.26 ± 0.414
2.762AsnGln: 2.762 ± 0.541
2.679AsnArg: 2.679 ± 0.45
2.679AsnSer: 2.679 ± 0.475
2.511AsnThr: 2.511 ± 0.491
3.181AsnVal: 3.181 ± 0.594
0.921AsnTrp: 0.921 ± 0.316
1.674AsnTyr: 1.674 ± 0.393
0.0AsnXaa: 0.0 ± 0.0
Pro
1.925ProAla: 1.925 ± 0.412
0.084ProCys: 0.084 ± 0.083
1.842ProAsp: 1.842 ± 0.472
1.507ProGlu: 1.507 ± 0.377
1.507ProPhe: 1.507 ± 0.371
1.423ProGly: 1.423 ± 0.385
0.335ProHis: 0.335 ± 0.155
2.176ProIle: 2.176 ± 0.356
2.511ProLys: 2.511 ± 0.445
1.758ProLeu: 1.758 ± 0.384
0.335ProMet: 0.335 ± 0.178
0.837ProAsn: 0.837 ± 0.245
0.67ProPro: 0.67 ± 0.212
1.758ProGln: 1.758 ± 0.363
0.921ProArg: 0.921 ± 0.335
1.758ProSer: 1.758 ± 0.315
1.172ProThr: 1.172 ± 0.23
2.344ProVal: 2.344 ± 0.383
0.251ProTrp: 0.251 ± 0.145
1.172ProTyr: 1.172 ± 0.319
0.0ProXaa: 0.0 ± 0.0
Gln
5.692GlnAla: 5.692 ± 0.817
0.335GlnCys: 0.335 ± 0.14
2.009GlnAsp: 2.009 ± 0.336
3.097GlnGlu: 3.097 ± 0.563
1.758GlnPhe: 1.758 ± 0.373
2.679GlnGly: 2.679 ± 0.577
0.586GlnHis: 0.586 ± 0.272
3.097GlnIle: 3.097 ± 0.435
3.683GlnLys: 3.683 ± 0.65
4.771GlnLeu: 4.771 ± 0.683
1.674GlnMet: 1.674 ± 0.382
2.595GlnAsn: 2.595 ± 0.405
0.753GlnPro: 0.753 ± 0.228
1.758GlnGln: 1.758 ± 0.47
2.428GlnArg: 2.428 ± 0.412
2.344GlnSer: 2.344 ± 0.372
2.762GlnThr: 2.762 ± 0.506
2.595GlnVal: 2.595 ± 0.462
0.251GlnTrp: 0.251 ± 0.156
2.009GlnTyr: 2.009 ± 0.489
0.0GlnXaa: 0.0 ± 0.0
Arg
2.679ArgAla: 2.679 ± 0.565
0.167ArgCys: 0.167 ± 0.122
1.423ArgAsp: 1.423 ± 0.352
4.018ArgGlu: 4.018 ± 0.657
2.428ArgPhe: 2.428 ± 0.439
3.097ArgGly: 3.097 ± 0.744
0.335ArgHis: 0.335 ± 0.156
2.762ArgIle: 2.762 ± 0.445
4.102ArgLys: 4.102 ± 0.771
3.6ArgLeu: 3.6 ± 0.464
1.339ArgMet: 1.339 ± 0.412
2.344ArgAsn: 2.344 ± 0.471
1.59ArgPro: 1.59 ± 0.391
2.762ArgGln: 2.762 ± 0.43
2.428ArgArg: 2.428 ± 0.541
3.014ArgSer: 3.014 ± 0.58
2.093ArgThr: 2.093 ± 0.422
4.102ArgVal: 4.102 ± 0.676
0.67ArgTrp: 0.67 ± 0.25
2.846ArgTyr: 2.846 ± 0.603
0.0ArgXaa: 0.0 ± 0.0
Ser
5.441SerAla: 5.441 ± 1.502
0.251SerCys: 0.251 ± 0.134
4.186SerAsp: 4.186 ± 0.782
3.851SerGlu: 3.851 ± 0.574
2.26SerPhe: 2.26 ± 0.436
4.604SerGly: 4.604 ± 0.594
0.335SerHis: 0.335 ± 0.165
4.688SerIle: 4.688 ± 0.899
4.771SerLys: 4.771 ± 0.548
5.441SerLeu: 5.441 ± 0.732
1.674SerMet: 1.674 ± 0.573
2.344SerAsn: 2.344 ± 0.372
2.009SerPro: 2.009 ± 0.416
2.344SerGln: 2.344 ± 0.461
2.093SerArg: 2.093 ± 0.394
4.353SerSer: 4.353 ± 1.353
2.762SerThr: 2.762 ± 0.556
4.604SerVal: 4.604 ± 0.891
1.088SerTrp: 1.088 ± 0.352
2.93SerTyr: 2.93 ± 0.502
0.0SerXaa: 0.0 ± 0.0
Thr
3.851ThrAla: 3.851 ± 0.775
0.335ThrCys: 0.335 ± 0.209
2.511ThrAsp: 2.511 ± 0.524
3.851ThrGlu: 3.851 ± 0.505
2.679ThrPhe: 2.679 ± 0.459
4.939ThrGly: 4.939 ± 0.813
0.753ThrHis: 0.753 ± 0.317
5.19ThrIle: 5.19 ± 0.733
3.265ThrLys: 3.265 ± 0.54
3.767ThrLeu: 3.767 ± 0.615
1.172ThrMet: 1.172 ± 0.287
2.344ThrAsn: 2.344 ± 0.427
2.093ThrPro: 2.093 ± 0.362
2.679ThrGln: 2.679 ± 0.446
2.176ThrArg: 2.176 ± 0.434
3.014ThrSer: 3.014 ± 0.513
3.683ThrThr: 3.683 ± 0.508
4.353ThrVal: 4.353 ± 0.529
0.753ThrTrp: 0.753 ± 0.267
1.507ThrTyr: 1.507 ± 0.389
0.0ThrXaa: 0.0 ± 0.0
Val
5.357ValAla: 5.357 ± 1.141
0.251ValCys: 0.251 ± 0.143
4.855ValAsp: 4.855 ± 0.667
5.943ValGlu: 5.943 ± 0.695
1.758ValPhe: 1.758 ± 0.495
4.688ValGly: 4.688 ± 0.944
1.005ValHis: 1.005 ± 0.318
4.018ValIle: 4.018 ± 0.627
4.855ValLys: 4.855 ± 0.646
5.357ValLeu: 5.357 ± 0.674
2.093ValMet: 2.093 ± 0.348
3.432ValAsn: 3.432 ± 0.582
1.674ValPro: 1.674 ± 0.43
3.014ValGln: 3.014 ± 0.559
3.432ValArg: 3.432 ± 0.598
5.357ValSer: 5.357 ± 0.965
4.771ValThr: 4.771 ± 0.58
6.278ValVal: 6.278 ± 0.699
0.837ValTrp: 0.837 ± 0.256
2.511ValTyr: 2.511 ± 0.465
0.0ValXaa: 0.0 ± 0.0
Trp
0.67TrpAla: 0.67 ± 0.29
0.0TrpCys: 0.0 ± 0.0
1.005TrpAsp: 1.005 ± 0.304
0.837TrpGlu: 0.837 ± 0.245
0.753TrpPhe: 0.753 ± 0.228
0.921TrpGly: 0.921 ± 0.387
0.167TrpHis: 0.167 ± 0.109
0.586TrpIle: 0.586 ± 0.244
0.921TrpLys: 0.921 ± 0.314
1.507TrpLeu: 1.507 ± 0.425
0.0TrpMet: 0.0 ± 0.0
0.67TrpAsn: 0.67 ± 0.256
0.0TrpPro: 0.0 ± 0.0
1.005TrpGln: 1.005 ± 0.337
1.088TrpArg: 1.088 ± 0.294
0.837TrpSer: 0.837 ± 0.247
0.586TrpThr: 0.586 ± 0.209
0.335TrpVal: 0.335 ± 0.164
0.084TrpTrp: 0.084 ± 0.097
0.335TrpTyr: 0.335 ± 0.149
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.516TyrAla: 3.516 ± 0.498
0.335TyrCys: 0.335 ± 0.186
2.176TyrAsp: 2.176 ± 0.525
2.846TyrGlu: 2.846 ± 0.565
1.172TyrPhe: 1.172 ± 0.345
2.26TyrGly: 2.26 ± 0.446
0.753TyrHis: 0.753 ± 0.375
1.758TyrIle: 1.758 ± 0.343
3.014TyrLys: 3.014 ± 0.529
3.767TyrLeu: 3.767 ± 0.918
0.502TyrMet: 0.502 ± 0.215
1.842TyrAsn: 1.842 ± 0.308
1.005TyrPro: 1.005 ± 0.35
1.507TyrGln: 1.507 ± 0.352
2.009TyrArg: 2.009 ± 0.541
2.679TyrSer: 2.679 ± 0.519
1.842TyrThr: 1.842 ± 0.404
1.758TyrVal: 1.758 ± 0.381
0.753TyrTrp: 0.753 ± 0.244
2.009TyrTyr: 2.009 ± 0.419
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 67 proteins (11947 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski