Amino acid dipepetide frequency for Labedaea rhizosphaerae

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	20.683AlaAla: 20.683 ± 0.15	1.078AlaCys: 1.078 ± 0.02	8.895AlaAsp: 8.895 ± 0.064	8.649AlaGlu: 8.649 ± 0.065	3.506AlaPhe: 3.506 ± 0.038	12.622AlaGly: 12.622 ± 0.091	2.739AlaHis: 2.739 ± 0.033	4.569AlaIle: 4.569 ± 0.045	3.307AlaLys: 3.307 ± 0.048	13.937AlaLeu: 13.937 ± 0.104	2.845AlaMet: 2.845 ± 0.032	2.453AlaAsn: 2.453 ± 0.033	6.238AlaPro: 6.238 ± 0.062	4.011AlaGln: 4.011 ± 0.037	9.127AlaArg: 9.127 ± 0.076	5.868AlaSer: 5.868 ± 0.052	7.751AlaThr: 7.751 ± 0.066	12.452AlaVal: 12.452 ± 0.089	1.873AlaTrp: 1.873 ± 0.031	2.318AlaTyr: 2.318 ± 0.032	0.0AlaXaa: 0.0 ± 0.0
Cys	1.067CysAla: 1.067 ± 0.022	0.096CysCys: 0.096 ± 0.007	0.503CysAsp: 0.503 ± 0.015	0.365CysGlu: 0.365 ± 0.011	0.21CysPhe: 0.21 ± 0.009	0.928CysGly: 0.928 ± 0.021	0.194CysHis: 0.194 ± 0.009	0.168CysIle: 0.168 ± 0.008	0.144CysLys: 0.144 ± 0.008	0.716CysLeu: 0.716 ± 0.018	0.12CysMet: 0.12 ± 0.007	0.129CysAsn: 0.129 ± 0.008	0.478CysPro: 0.478 ± 0.014	0.198CysGln: 0.198 ± 0.008	0.568CysArg: 0.568 ± 0.015	0.455CysSer: 0.455 ± 0.015	0.539CysThr: 0.539 ± 0.017	0.713CysVal: 0.713 ± 0.018	0.145CysTrp: 0.145 ± 0.007	0.172CysTyr: 0.172 ± 0.008	0.0CysXaa: 0.0 ± 0.0
Asp	7.982AspAla: 7.982 ± 0.075	0.434AspCys: 0.434 ± 0.015	4.187AspAsp: 4.187 ± 0.048	4.22AspGlu: 4.22 ± 0.053	1.531AspPhe: 1.531 ± 0.027	6.48AspGly: 6.48 ± 0.061	1.497AspHis: 1.497 ± 0.024	1.825AspIle: 1.825 ± 0.032	1.346AspLys: 1.346 ± 0.028	6.679AspLeu: 6.679 ± 0.058	0.853AspMet: 0.853 ± 0.021	1.145AspAsn: 1.145 ± 0.027	4.639AspPro: 4.639 ± 0.044	2.046AspGln: 2.046 ± 0.033	5.017AspArg: 5.017 ± 0.057	2.457AspSer: 2.457 ± 0.033	3.191AspThr: 3.191 ± 0.033	5.469AspVal: 5.469 ± 0.055	1.049AspTrp: 1.049 ± 0.022	1.278AspTyr: 1.278 ± 0.026	0.0AspXaa: 0.0 ± 0.0
Glu	6.096GluAla: 6.096 ± 0.07	0.374GluCys: 0.374 ± 0.013	2.614GluAsp: 2.614 ± 0.035	2.485GluGlu: 2.485 ± 0.038	1.751GluPhe: 1.751 ± 0.027	3.273GluGly: 3.273 ± 0.042	1.769GluHis: 1.769 ± 0.027	1.994GluIle: 1.994 ± 0.028	1.093GluLys: 1.093 ± 0.025	7.49GluLeu: 7.49 ± 0.073	0.806GluMet: 0.806 ± 0.019	0.921GluAsn: 0.921 ± 0.022	3.435GluPro: 3.435 ± 0.048	2.427GluGln: 2.427 ± 0.033	4.759GluArg: 4.759 ± 0.052	2.436GluSer: 2.436 ± 0.032	2.561GluThr: 2.561 ± 0.035	4.67GluVal: 4.67 ± 0.048	0.749GluTrp: 0.749 ± 0.018	0.972GluTyr: 0.972 ± 0.02	0.0GluXaa: 0.0 ± 0.0
Phe	4.061PheAla: 4.061 ± 0.042	0.28PheCys: 0.28 ± 0.011	2.278PheAsp: 2.278 ± 0.03	1.365PheGlu: 1.365 ± 0.025	0.837PhePhe: 0.837 ± 0.022	3.267PheGly: 3.267 ± 0.044	0.625PheHis: 0.625 ± 0.015	0.706PheIle: 0.706 ± 0.018	0.443PheLys: 0.443 ± 0.014	2.444PheLeu: 2.444 ± 0.035	0.384PheMet: 0.384 ± 0.013	0.538PheAsn: 0.538 ± 0.016	1.357PhePro: 1.357 ± 0.023	0.681PheGln: 0.681 ± 0.016	1.74PheArg: 1.74 ± 0.031	1.357PheSer: 1.357 ± 0.023	2.057PheThr: 2.057 ± 0.028	2.525PheVal: 2.525 ± 0.03	0.424PheTrp: 0.424 ± 0.014	0.582PheTyr: 0.582 ± 0.015	0.0PheXaa: 0.0 ± 0.0
Gly	10.376GlyAla: 10.376 ± 0.079	0.806GlyCys: 0.806 ± 0.018	5.17GlyAsp: 5.17 ± 0.051	4.707GlyGlu: 4.707 ± 0.047	2.966GlyPhe: 2.966 ± 0.037	8.232GlyGly: 8.232 ± 0.094	2.264GlyHis: 2.264 ± 0.033	3.59GlyIle: 3.59 ± 0.041	2.607GlyLys: 2.607 ± 0.037	9.079GlyLeu: 9.079 ± 0.074	2.164GlyMet: 2.164 ± 0.027	1.875GlyAsn: 1.875 ± 0.039	4.705GlyPro: 4.705 ± 0.05	2.798GlyGln: 2.798 ± 0.038	6.513GlyArg: 6.513 ± 0.053	5.047GlySer: 5.047 ± 0.064	6.029GlyThr: 6.029 ± 0.071	7.982GlyVal: 7.982 ± 0.071	1.769GlyTrp: 1.769 ± 0.027	2.358GlyTyr: 2.358 ± 0.031	0.0GlyXaa: 0.0 ± 0.0
His	2.764HisAla: 2.764 ± 0.038	0.21HisCys: 0.21 ± 0.01	1.554HisAsp: 1.554 ± 0.023	1.256HisGlu: 1.256 ± 0.024	0.604HisPhe: 0.604 ± 0.014	2.395HisGly: 2.395 ± 0.028	0.716HisHis: 0.716 ± 0.022	0.613HisIle: 0.613 ± 0.016	0.378HisLys: 0.378 ± 0.012	2.381HisLeu: 2.381 ± 0.034	0.333HisMet: 0.333 ± 0.012	0.437HisAsn: 0.437 ± 0.015	1.684HisPro: 1.684 ± 0.03	0.716HisGln: 0.716 ± 0.02	1.933HisArg: 1.933 ± 0.03	0.988HisSer: 0.988 ± 0.022	1.197HisThr: 1.197 ± 0.023	1.94HisVal: 1.94 ± 0.029	0.401HisTrp: 0.401 ± 0.014	0.503HisTyr: 0.503 ± 0.015	0.0HisXaa: 0.0 ± 0.0
Ile	5.443IleAla: 5.443 ± 0.054	0.268IleCys: 0.268 ± 0.01	2.589IleAsp: 2.589 ± 0.03	2.144IleGlu: 2.144 ± 0.034	0.72IlePhe: 0.72 ± 0.017	3.941IleGly: 3.941 ± 0.044	0.595IleHis: 0.595 ± 0.014	0.936IleIle: 0.936 ± 0.022	0.797IleLys: 0.797 ± 0.021	2.293IleLeu: 2.293 ± 0.036	0.471IleMet: 0.471 ± 0.016	0.793IleAsn: 0.793 ± 0.018	1.804IlePro: 1.804 ± 0.03	0.729IleGln: 0.729 ± 0.016	2.196IleArg: 2.196 ± 0.032	1.72IleSer: 1.72 ± 0.027	2.575IleThr: 2.575 ± 0.035	2.977IleVal: 2.977 ± 0.039	0.381IleTrp: 0.381 ± 0.012	0.594IleTyr: 0.594 ± 0.016	0.0IleXaa: 0.0 ± 0.0
Lys	2.955LysAla: 2.955 ± 0.041	0.107LysCys: 0.107 ± 0.007	1.163LysAsp: 1.163 ± 0.028	0.971LysGlu: 0.971 ± 0.024	0.546LysPhe: 0.546 ± 0.016	1.532LysGly: 1.532 ± 0.028	0.524LysHis: 0.524 ± 0.015	0.94LysIle: 0.94 ± 0.023	0.608LysLys: 0.608 ± 0.021	2.323LysLeu: 2.323 ± 0.037	0.395LysMet: 0.395 ± 0.013	0.452LysAsn: 0.452 ± 0.015	1.614LysPro: 1.614 ± 0.028	0.803LysGln: 0.803 ± 0.017	1.582LysArg: 1.582 ± 0.032	1.127LysSer: 1.127 ± 0.022	1.313LysThr: 1.313 ± 0.027	2.098LysVal: 2.098 ± 0.034	0.283LysTrp: 0.283 ± 0.011	0.424LysTyr: 0.424 ± 0.015	0.0LysXaa: 0.0 ± 0.0
Leu	16.179LeuAla: 16.179 ± 0.104	0.813LeuCys: 0.813 ± 0.021	7.203LeuAsp: 7.203 ± 0.066	4.182LeuGlu: 4.182 ± 0.048	2.644LeuPhe: 2.644 ± 0.037	9.281LeuGly: 9.281 ± 0.07	2.281LeuHis: 2.281 ± 0.027	3.371LeuIle: 3.371 ± 0.049	1.612LeuLys: 1.612 ± 0.03	10.608LeuLeu: 10.608 ± 0.098	1.503LeuMet: 1.503 ± 0.025	1.76LeuAsn: 1.76 ± 0.027	6.27LeuPro: 6.27 ± 0.055	2.18LeuGln: 2.18 ± 0.038	8.654LeuArg: 8.654 ± 0.076	5.269LeuSer: 5.269 ± 0.048	6.771LeuThr: 6.771 ± 0.057	9.861LeuVal: 9.861 ± 0.075	1.282LeuTrp: 1.282 ± 0.025	1.678LeuTyr: 1.678 ± 0.028	0.0LeuXaa: 0.0 ± 0.0
Met	2.366MetAla: 2.366 ± 0.032	0.121MetCys: 0.121 ± 0.007	0.914MetAsp: 0.914 ± 0.017	0.605MetGlu: 0.605 ± 0.017	0.494MetPhe: 0.494 ± 0.014	1.251MetGly: 1.251 ± 0.026	0.378MetHis: 0.378 ± 0.013	0.764MetIle: 0.764 ± 0.019	0.387MetLys: 0.387 ± 0.01	1.845MetLeu: 1.845 ± 0.029	0.268MetMet: 0.268 ± 0.012	0.423MetAsn: 0.423 ± 0.012	1.165MetPro: 1.165 ± 0.023	0.487MetGln: 0.487 ± 0.014	1.525MetArg: 1.525 ± 0.023	1.277MetSer: 1.277 ± 0.022	1.75MetThr: 1.75 ± 0.029	1.492MetVal: 1.492 ± 0.022	0.206MetTrp: 0.206 ± 0.009	0.257MetTyr: 0.257 ± 0.011	0.0MetXaa: 0.0 ± 0.0
Asn	2.489AsnAla: 2.489 ± 0.036	0.165AsnCys: 0.165 ± 0.009	1.056AsnAsp: 1.056 ± 0.021	0.882AsnGlu: 0.882 ± 0.018	0.503AsnPhe: 0.503 ± 0.016	2.158AsnGly: 2.158 ± 0.045	0.443AsnHis: 0.443 ± 0.012	0.603AsnIle: 0.603 ± 0.016	0.427AsnLys: 0.427 ± 0.014	1.815AsnLeu: 1.815 ± 0.028	0.303AsnMet: 0.303 ± 0.011	0.495AsnAsn: 0.495 ± 0.017	1.538AsnPro: 1.538 ± 0.027	0.627AsnGln: 0.627 ± 0.016	1.366AsnArg: 1.366 ± 0.024	0.991AsnSer: 0.991 ± 0.024	1.191AsnThr: 1.191 ± 0.031	1.433AsnVal: 1.433 ± 0.023	0.294AsnTrp: 0.294 ± 0.011	0.482AsnTyr: 0.482 ± 0.014	0.0AsnXaa: 0.0 ± 0.0
Pro	8.008ProAla: 8.008 ± 0.067	0.333ProCys: 0.333 ± 0.012	4.752ProAsp: 4.752 ± 0.046	3.694ProGlu: 3.694 ± 0.047	1.498ProPhe: 1.498 ± 0.028	6.063ProGly: 6.063 ± 0.062	1.192ProHis: 1.192 ± 0.023	1.773ProIle: 1.773 ± 0.028	1.346ProLys: 1.346 ± 0.025	4.846ProLeu: 4.846 ± 0.051	1.127ProMet: 1.127 ± 0.02	1.208ProAsn: 1.208 ± 0.024	3.436ProPro: 3.436 ± 0.062	1.75ProGln: 1.75 ± 0.033	3.518ProArg: 3.518 ± 0.04	3.152ProSer: 3.152 ± 0.041	3.373ProThr: 3.373 ± 0.043	5.669ProVal: 5.669 ± 0.052	0.94ProTrp: 0.94 ± 0.024	1.059ProTyr: 1.059 ± 0.025	0.0ProXaa: 0.0 ± 0.0
Gln	4.096GlnAla: 4.096 ± 0.045	0.208GlnCys: 0.208 ± 0.009	1.478GlnAsp: 1.478 ± 0.025	1.25GlnGlu: 1.25 ± 0.022	0.849GlnPhe: 0.849 ± 0.018	2.168GlnGly: 2.168 ± 0.037	0.758GlnHis: 0.758 ± 0.018	0.985GlnIle: 0.985 ± 0.023	0.532GlnLys: 0.532 ± 0.018	3.449GlnLeu: 3.449 ± 0.044	0.46GlnMet: 0.46 ± 0.015	0.545GlnAsn: 0.545 ± 0.019	1.972GlnPro: 1.972 ± 0.033	1.437GlnGln: 1.437 ± 0.033	2.655GlnArg: 2.655 ± 0.031	1.369GlnSer: 1.369 ± 0.026	1.504GlnThr: 1.504 ± 0.028	2.928GlnVal: 2.928 ± 0.033	0.53GlnTrp: 0.53 ± 0.014	0.592GlnTyr: 0.592 ± 0.015	0.0GlnXaa: 0.0 ± 0.0
Arg	9.144ArgAla: 9.144 ± 0.07	0.628ArgCys: 0.628 ± 0.016	4.263ArgAsp: 4.263 ± 0.051	4.03ArgGlu: 4.03 ± 0.055	2.399ArgPhe: 2.399 ± 0.032	5.401ArgGly: 5.401 ± 0.051	1.867ArgHis: 1.867 ± 0.028	3.016ArgIle: 3.016 ± 0.038	1.899ArgLys: 1.899 ± 0.03	8.255ArgLeu: 8.255 ± 0.071	1.8ArgMet: 1.8 ± 0.03	1.408ArgAsn: 1.408 ± 0.025	4.359ArgPro: 4.359 ± 0.047	2.292ArgGln: 2.292 ± 0.03	6.772ArgArg: 6.772 ± 0.065	3.861ArgSer: 3.861 ± 0.042	4.68ArgThr: 4.68 ± 0.046	5.856ArgVal: 5.856 ± 0.047	1.396ArgTrp: 1.396 ± 0.022	1.831ArgTyr: 1.831 ± 0.029	0.0ArgXaa: 0.0 ± 0.0
Ser	6.612SerAla: 6.612 ± 0.056	0.442SerCys: 0.442 ± 0.015	2.637SerAsp: 2.637 ± 0.035	2.107SerGlu: 2.107 ± 0.029	1.503SerPhe: 1.503 ± 0.028	5.758SerGly: 5.758 ± 0.057	0.916SerHis: 0.916 ± 0.019	1.778SerIle: 1.778 ± 0.024	1.082SerLys: 1.082 ± 0.024	4.703SerLeu: 4.703 ± 0.053	1.221SerMet: 1.221 ± 0.024	0.967SerAsn: 0.967 ± 0.022	2.851SerPro: 2.851 ± 0.037	1.295SerGln: 1.295 ± 0.024	3.262SerArg: 3.262 ± 0.035	2.968SerSer: 2.968 ± 0.045	3.506SerThr: 3.506 ± 0.049	4.511SerVal: 4.511 ± 0.045	0.939SerTrp: 0.939 ± 0.02	1.108SerTyr: 1.108 ± 0.024	0.0SerXaa: 0.0 ± 0.0
Thr	8.403ThrAla: 8.403 ± 0.078	0.441ThrCys: 0.441 ± 0.014	3.772ThrAsp: 3.772 ± 0.042	3.424ThrGlu: 3.424 ± 0.036	1.669ThrPhe: 1.669 ± 0.026	6.557ThrGly: 6.557 ± 0.067	1.181ThrHis: 1.181 ± 0.022	2.234ThrIle: 2.234 ± 0.033	1.463ThrLys: 1.463 ± 0.029	5.509ThrLeu: 5.509 ± 0.046	1.125ThrMet: 1.125 ± 0.022	1.222ThrAsn: 1.222 ± 0.028	3.863ThrPro: 3.863 ± 0.048	1.59ThrGln: 1.59 ± 0.031	3.681ThrArg: 3.681 ± 0.038	3.371ThrSer: 3.371 ± 0.049	4.486ThrThr: 4.486 ± 0.078	6.356ThrVal: 6.356 ± 0.062	0.952ThrTrp: 0.952 ± 0.021	1.327ThrTyr: 1.327 ± 0.027	0.0ThrXaa: 0.0 ± 0.0
Val	12.18ValAla: 12.18 ± 0.093	0.768ValCys: 0.768 ± 0.019	6.149ValAsp: 6.149 ± 0.057	4.779ValGlu: 4.779 ± 0.051	2.565ValPhe: 2.565 ± 0.034	6.766ValGly: 6.766 ± 0.049	2.194ValHis: 2.194 ± 0.033	3.165ValIle: 3.165 ± 0.036	1.67ValLys: 1.67 ± 0.026	10.771ValLeu: 10.771 ± 0.083	1.303ValMet: 1.303 ± 0.025	1.724ValAsn: 1.724 ± 0.028	5.295ValPro: 5.295 ± 0.051	2.291ValGln: 2.291 ± 0.03	7.045ValArg: 7.045 ± 0.058	4.538ValSer: 4.538 ± 0.053	5.886ValThr: 5.886 ± 0.058	9.493ValVal: 9.493 ± 0.088	1.108ValTrp: 1.108 ± 0.021	1.465ValTyr: 1.465 ± 0.028	0.0ValXaa: 0.0 ± 0.0
Trp	1.65TrpAla: 1.65 ± 0.028	0.166TrpCys: 0.166 ± 0.008	0.776TrpAsp: 0.776 ± 0.018	0.583TrpGlu: 0.583 ± 0.015	0.537TrpPhe: 0.537 ± 0.014	1.023TrpGly: 1.023 ± 0.025	0.419TrpHis: 0.419 ± 0.013	0.508TrpIle: 0.508 ± 0.016	0.265TrpLys: 0.265 ± 0.01	2.03TrpLeu: 2.03 ± 0.03	0.272TrpMet: 0.272 ± 0.01	0.338TrpAsn: 0.338 ± 0.013	0.88TrpPro: 0.88 ± 0.02	0.711TrpGln: 0.711 ± 0.017	1.44TrpArg: 1.44 ± 0.026	0.955TrpSer: 0.955 ± 0.022	1.077TrpThr: 1.077 ± 0.024	1.141TrpVal: 1.141 ± 0.024	0.365TrpTrp: 0.365 ± 0.013	0.31TrpTyr: 0.31 ± 0.012	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.367TyrAla: 2.367 ± 0.03	0.172TyrCys: 0.172 ± 0.009	1.372TyrAsp: 1.372 ± 0.035	0.979TyrGlu: 0.979 ± 0.02	0.618TyrPhe: 0.618 ± 0.018	1.94TyrGly: 1.94 ± 0.031	0.452TyrHis: 0.452 ± 0.013	0.429TyrIle: 0.429 ± 0.014	0.355TyrLys: 0.355 ± 0.014	2.233TyrLeu: 2.233 ± 0.031	0.222TyrMet: 0.222 ± 0.009	0.429TyrAsn: 0.429 ± 0.016	1.15TyrPro: 1.15 ± 0.023	0.695TyrGln: 0.695 ± 0.018	1.804TyrArg: 1.804 ± 0.028	0.957TyrSer: 0.957 ± 0.021	1.187TyrThr: 1.187 ± 0.026	1.591TyrVal: 1.591 ± 0.028	0.357TyrTrp: 0.357 ± 0.013	0.451TyrTyr: 0.451 ± 0.015	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 7717 proteins (2529000 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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