Amino acid dipepetide frequency for Glarea lozoyensis (strain ATCC 74030 / MF5533)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	9.251AlaAla: 9.251 ± 0.082	0.885AlaCys: 0.885 ± 0.017	4.117AlaAsp: 4.117 ± 0.043	5.73AlaGlu: 5.73 ± 0.053	3.041AlaPhe: 3.041 ± 0.039	6.13AlaGly: 6.13 ± 0.061	1.606AlaHis: 1.606 ± 0.026	4.616AlaIle: 4.616 ± 0.044	5.171AlaLys: 5.171 ± 0.052	7.45AlaLeu: 7.45 ± 0.063	2.122AlaMet: 2.122 ± 0.028	3.111AlaAsn: 3.111 ± 0.041	4.511AlaPro: 4.511 ± 0.06	3.356AlaGln: 3.356 ± 0.046	4.568AlaArg: 4.568 ± 0.042	6.609AlaSer: 6.609 ± 0.07	5.287AlaThr: 5.287 ± 0.052	5.466AlaVal: 5.466 ± 0.047	1.055AlaTrp: 1.055 ± 0.022	2.129AlaTyr: 2.129 ± 0.031	0.002AlaXaa: 0.002 ± 0.001
Cys	0.781CysAla: 0.781 ± 0.02	0.178CysCys: 0.178 ± 0.01	0.558CysAsp: 0.558 ± 0.014	0.567CysGlu: 0.567 ± 0.016	0.431CysPhe: 0.431 ± 0.014	0.875CysGly: 0.875 ± 0.02	0.252CysHis: 0.252 ± 0.01	0.575CysIle: 0.575 ± 0.014	0.532CysLys: 0.532 ± 0.018	0.958CysLeu: 0.958 ± 0.019	0.239CysMet: 0.239 ± 0.01	0.366CysAsn: 0.366 ± 0.012	0.533CysPro: 0.533 ± 0.016	0.367CysGln: 0.367 ± 0.012	0.482CysArg: 0.482 ± 0.013	0.708CysSer: 0.708 ± 0.017	0.584CysThr: 0.584 ± 0.015	0.695CysVal: 0.695 ± 0.017	0.179CysTrp: 0.179 ± 0.009	0.316CysTyr: 0.316 ± 0.012	0.0CysXaa: 0.0 ± 0.0
Asp	4.81AspAla: 4.81 ± 0.052	0.587AspCys: 0.587 ± 0.015	4.423AspAsp: 4.423 ± 0.063	5.41AspGlu: 5.41 ± 0.062	2.34AspPhe: 2.34 ± 0.032	4.2AspGly: 4.2 ± 0.043	1.137AspHis: 1.137 ± 0.02	3.338AspIle: 3.338 ± 0.037	2.85AspLys: 2.85 ± 0.039	5.158AspLeu: 5.158 ± 0.051	1.421AspMet: 1.421 ± 0.026	2.041AspAsn: 2.041 ± 0.026	3.147AspPro: 3.147 ± 0.035	1.848AspGln: 1.848 ± 0.027	2.76AspArg: 2.76 ± 0.039	3.993AspSer: 3.993 ± 0.044	3.004AspThr: 3.004 ± 0.03	3.999AspVal: 3.999 ± 0.044	0.841AspTrp: 0.841 ± 0.02	1.616AspTyr: 1.616 ± 0.024	0.0AspXaa: 0.0 ± 0.0
Glu	6.061GluAla: 6.061 ± 0.058	0.556GluCys: 0.556 ± 0.016	5.102GluAsp: 5.102 ± 0.065	7.19GluGlu: 7.19 ± 0.105	2.323GluPhe: 2.323 ± 0.027	4.547GluGly: 4.547 ± 0.046	1.387GluHis: 1.387 ± 0.023	3.85GluIle: 3.85 ± 0.042	5.188GluLys: 5.188 ± 0.056	5.562GluLeu: 5.562 ± 0.055	1.857GluMet: 1.857 ± 0.027	2.779GluAsn: 2.779 ± 0.038	2.692GluPro: 2.692 ± 0.055	2.494GluGln: 2.494 ± 0.035	4.133GluArg: 4.133 ± 0.055	4.505GluSer: 4.505 ± 0.051	3.671GluThr: 3.671 ± 0.045	4.47GluVal: 4.47 ± 0.048	0.922GluTrp: 0.922 ± 0.019	1.774GluTyr: 1.774 ± 0.027	0.0GluXaa: 0.0 ± 0.0
Phe	3.046PheAla: 3.046 ± 0.037	0.502PheCys: 0.502 ± 0.014	2.414PheAsp: 2.414 ± 0.033	2.538PheGlu: 2.538 ± 0.034	1.556PhePhe: 1.556 ± 0.027	3.018PheGly: 3.018 ± 0.04	0.79PheHis: 0.79 ± 0.019	1.826PheIle: 1.826 ± 0.027	1.94PheLys: 1.94 ± 0.025	3.115PheLeu: 3.115 ± 0.038	0.831PheMet: 0.831 ± 0.018	1.543PheAsn: 1.543 ± 0.026	1.716PhePro: 1.716 ± 0.023	1.345PheGln: 1.345 ± 0.024	1.755PheArg: 1.755 ± 0.026	2.758PheSer: 2.758 ± 0.036	2.177PheThr: 2.177 ± 0.028	2.416PheVal: 2.416 ± 0.035	0.584PheTrp: 0.584 ± 0.018	1.088PheTyr: 1.088 ± 0.02	0.0PheXaa: 0.0 ± 0.0
Gly	5.537GlyAla: 5.537 ± 0.059	0.797GlyCys: 0.797 ± 0.021	3.922GlyAsp: 3.922 ± 0.045	4.271GlyGlu: 4.271 ± 0.04	2.939GlyPhe: 2.939 ± 0.042	6.742GlyGly: 6.742 ± 0.085	1.523GlyHis: 1.523 ± 0.031	3.849GlyIle: 3.849 ± 0.039	4.5GlyLys: 4.5 ± 0.046	5.956GlyLeu: 5.956 ± 0.047	1.753GlyMet: 1.753 ± 0.028	2.824GlyAsn: 2.824 ± 0.039	3.069GlyPro: 3.069 ± 0.041	2.384GlyGln: 2.384 ± 0.033	3.935GlyArg: 3.935 ± 0.054	5.505GlySer: 5.505 ± 0.051	4.131GlyThr: 4.131 ± 0.045	4.967GlyVal: 4.967 ± 0.046	1.141GlyTrp: 1.141 ± 0.025	2.17GlyTyr: 2.17 ± 0.032	0.001GlyXaa: 0.001 ± 0.001
His	1.537HisAla: 1.537 ± 0.028	0.25HisCys: 0.25 ± 0.01	1.217HisAsp: 1.217 ± 0.021	1.373HisGlu: 1.373 ± 0.025	0.867HisPhe: 0.867 ± 0.017	1.542HisGly: 1.542 ± 0.025	0.667HisHis: 0.667 ± 0.018	1.145HisIle: 1.145 ± 0.019	1.024HisLys: 1.024 ± 0.02	1.937HisLeu: 1.937 ± 0.029	0.485HisMet: 0.485 ± 0.011	0.843HisAsn: 0.843 ± 0.019	1.392HisPro: 1.392 ± 0.023	0.833HisGln: 0.833 ± 0.018	1.185HisArg: 1.185 ± 0.025	1.469HisSer: 1.469 ± 0.024	1.147HisThr: 1.147 ± 0.023	1.293HisVal: 1.293 ± 0.022	0.288HisTrp: 0.288 ± 0.01	0.627HisTyr: 0.627 ± 0.016	0.0HisXaa: 0.0 ± 0.0
Ile	4.495IleAla: 4.495 ± 0.039	0.668IleCys: 0.668 ± 0.018	3.226IleAsp: 3.226 ± 0.035	3.533IleGlu: 3.533 ± 0.038	2.085IlePhe: 2.085 ± 0.029	3.504IleGly: 3.504 ± 0.038	1.242IleHis: 1.242 ± 0.023	2.774IleIle: 2.774 ± 0.032	2.952IleLys: 2.952 ± 0.039	4.578IleLeu: 4.578 ± 0.048	1.189IleMet: 1.189 ± 0.02	2.054IleAsn: 2.054 ± 0.028	3.059IlePro: 3.059 ± 0.035	1.996IleGln: 1.996 ± 0.032	2.701IleArg: 2.701 ± 0.031	3.83IleSer: 3.83 ± 0.036	3.079IleThr: 3.079 ± 0.037	3.369IleVal: 3.369 ± 0.038	0.716IleTrp: 0.716 ± 0.018	1.429IleTyr: 1.429 ± 0.027	0.0IleXaa: 0.0 ± 0.0
Lys	5.435LysAla: 5.435 ± 0.056	0.475LysCys: 0.475 ± 0.015	3.589LysAsp: 3.589 ± 0.042	4.649LysGlu: 4.649 ± 0.054	1.947LysPhe: 1.947 ± 0.029	3.806LysGly: 3.806 ± 0.045	1.268LysHis: 1.268 ± 0.022	3.112LysIle: 3.112 ± 0.034	5.033LysLys: 5.033 ± 0.094	4.773LysLeu: 4.773 ± 0.045	1.445LysMet: 1.445 ± 0.026	2.345LysAsn: 2.345 ± 0.032	3.028LysPro: 3.028 ± 0.046	2.111LysGln: 2.111 ± 0.028	3.764LysArg: 3.764 ± 0.056	4.269LysSer: 4.269 ± 0.052	3.518LysThr: 3.518 ± 0.034	3.676LysVal: 3.676 ± 0.046	0.786LysTrp: 0.786 ± 0.017	1.652LysTyr: 1.652 ± 0.028	0.001LysXaa: 0.001 ± 0.001
Leu	7.331LeuAla: 7.331 ± 0.062	0.918LeuCys: 0.918 ± 0.018	5.007LeuAsp: 5.007 ± 0.05	6.005LeuGlu: 6.005 ± 0.059	3.036LeuPhe: 3.036 ± 0.035	5.745LeuGly: 5.745 ± 0.055	1.863LeuHis: 1.863 ± 0.026	3.996LeuIle: 3.996 ± 0.04	5.028LeuLys: 5.028 ± 0.055	7.239LeuLeu: 7.239 ± 0.073	1.775LeuMet: 1.775 ± 0.026	3.28LeuAsn: 3.28 ± 0.035	4.687LeuPro: 4.687 ± 0.046	3.452LeuGln: 3.452 ± 0.045	5.019LeuArg: 5.019 ± 0.045	6.445LeuSer: 6.445 ± 0.059	4.641LeuThr: 4.641 ± 0.045	5.01LeuVal: 5.01 ± 0.049	1.017LeuTrp: 1.017 ± 0.02	2.098LeuTyr: 2.098 ± 0.03	0.0LeuXaa: 0.0 ± 0.0
Met	2.355MetAla: 2.355 ± 0.029	0.229MetCys: 0.229 ± 0.009	1.429MetAsp: 1.429 ± 0.025	1.544MetGlu: 1.544 ± 0.023	0.835MetPhe: 0.835 ± 0.018	1.671MetGly: 1.671 ± 0.028	0.43MetHis: 0.43 ± 0.012	1.176MetIle: 1.176 ± 0.021	1.362MetLys: 1.362 ± 0.024	1.832MetLeu: 1.832 ± 0.029	0.627MetMet: 0.627 ± 0.016	0.924MetAsn: 0.924 ± 0.019	1.172MetPro: 1.172 ± 0.024	0.849MetGln: 0.849 ± 0.021	1.261MetArg: 1.261 ± 0.023	1.934MetSer: 1.934 ± 0.028	1.342MetThr: 1.342 ± 0.02	1.434MetVal: 1.434 ± 0.022	0.261MetTrp: 0.261 ± 0.009	0.565MetTyr: 0.565 ± 0.013	0.0MetXaa: 0.0 ± 0.0
Asn	3.27AsnAla: 3.27 ± 0.038	0.409AsnCys: 0.409 ± 0.013	2.147AsnAsp: 2.147 ± 0.027	2.358AsnGlu: 2.358 ± 0.033	1.523AsnPhe: 1.523 ± 0.024	3.297AsnGly: 3.297 ± 0.046	0.871AsnHis: 0.871 ± 0.021	2.312AsnIle: 2.312 ± 0.03	1.958AsnLys: 1.958 ± 0.029	3.353AsnLeu: 3.353 ± 0.039	0.93AsnMet: 0.93 ± 0.018	1.667AsnAsn: 1.667 ± 0.033	2.502AsnPro: 2.502 ± 0.034	1.39AsnGln: 1.39 ± 0.025	1.853AsnArg: 1.853 ± 0.027	2.715AsnSer: 2.715 ± 0.036	2.39AsnThr: 2.39 ± 0.035	2.566AsnVal: 2.566 ± 0.034	0.562AsnTrp: 0.562 ± 0.016	1.113AsnTyr: 1.113 ± 0.023	0.0AsnXaa: 0.0 ± 0.0
Pro	4.797ProAla: 4.797 ± 0.056	0.374ProCys: 0.374 ± 0.013	2.863ProAsp: 2.863 ± 0.04	3.966ProGlu: 3.966 ± 0.047	1.814ProPhe: 1.814 ± 0.028	3.594ProGly: 3.594 ± 0.039	1.047ProHis: 1.047 ± 0.021	2.571ProIle: 2.571 ± 0.031	3.143ProLys: 3.143 ± 0.04	3.991ProLeu: 3.991 ± 0.04	0.993ProMet: 0.993 ± 0.021	2.191ProAsn: 2.191 ± 0.032	4.034ProPro: 4.034 ± 0.074	2.046ProGln: 2.046 ± 0.031	2.73ProArg: 2.73 ± 0.038	4.846ProSer: 4.846 ± 0.055	3.671ProThr: 3.671 ± 0.046	3.34ProVal: 3.34 ± 0.048	0.624ProTrp: 0.624 ± 0.014	1.351ProTyr: 1.351 ± 0.027	0.001ProXaa: 0.001 ± 0.0
Gln	3.309GlnAla: 3.309 ± 0.041	0.325GlnCys: 0.325 ± 0.01	2.074GlnAsp: 2.074 ± 0.03	2.552GlnGlu: 2.552 ± 0.037	1.276GlnPhe: 1.276 ± 0.024	2.2GlnGly: 2.2 ± 0.028	0.884GlnHis: 0.884 ± 0.021	2.041GlnIle: 2.041 ± 0.026	2.404GlnLys: 2.404 ± 0.031	3.099GlnLeu: 3.099 ± 0.038	0.962GlnMet: 0.962 ± 0.022	1.665GlnAsn: 1.665 ± 0.028	1.953GlnPro: 1.953 ± 0.034	1.94GlnGln: 1.94 ± 0.052	2.238GlnArg: 2.238 ± 0.028	2.639GlnSer: 2.639 ± 0.039	2.187GlnThr: 2.187 ± 0.032	2.11GlnVal: 2.11 ± 0.026	0.508GlnTrp: 0.508 ± 0.013	1.118GlnTyr: 1.118 ± 0.02	0.001GlnXaa: 0.001 ± 0.001
Arg	4.29ArgAla: 4.29 ± 0.043	0.522ArgCys: 0.522 ± 0.012	3.226ArgAsp: 3.226 ± 0.044	3.989ArgGlu: 3.989 ± 0.056	1.9ArgPhe: 1.9 ± 0.03	3.781ArgGly: 3.781 ± 0.052	1.182ArgHis: 1.182 ± 0.023	2.857ArgIle: 2.857 ± 0.036	3.808ArgLys: 3.808 ± 0.044	4.619ArgLeu: 4.619 ± 0.05	1.305ArgMet: 1.305 ± 0.02	2.178ArgAsn: 2.178 ± 0.029	2.732ArgPro: 2.732 ± 0.037	2.29ArgGln: 2.29 ± 0.034	3.967ArgArg: 3.967 ± 0.051	3.858ArgSer: 3.858 ± 0.047	2.882ArgThr: 2.882 ± 0.035	3.108ArgVal: 3.108 ± 0.033	0.74ArgTrp: 0.74 ± 0.015	1.468ArgTyr: 1.468 ± 0.024	0.001ArgXaa: 0.001 ± 0.001
Ser	6.246SerAla: 6.246 ± 0.056	0.696SerCys: 0.696 ± 0.018	4.119SerAsp: 4.119 ± 0.042	4.504SerGlu: 4.504 ± 0.047	2.706SerPhe: 2.706 ± 0.036	5.399SerGly: 5.399 ± 0.051	1.59SerHis: 1.59 ± 0.026	3.891SerIle: 3.891 ± 0.04	4.491SerLys: 4.491 ± 0.054	6.156SerLeu: 6.156 ± 0.052	1.668SerMet: 1.668 ± 0.024	2.999SerAsn: 2.999 ± 0.038	4.38SerPro: 4.38 ± 0.058	2.833SerGln: 2.833 ± 0.038	4.057SerArg: 4.057 ± 0.044	7.407SerSer: 7.407 ± 0.086	5.112SerThr: 5.112 ± 0.062	4.388SerVal: 4.388 ± 0.044	0.949SerTrp: 0.949 ± 0.02	1.949SerTyr: 1.949 ± 0.03	0.001SerXaa: 0.001 ± 0.001
Thr	5.158ThrAla: 5.158 ± 0.051	0.593ThrCys: 0.593 ± 0.017	2.832ThrAsp: 2.832 ± 0.034	3.391ThrGlu: 3.391 ± 0.037	2.289ThrPhe: 2.289 ± 0.03	4.307ThrGly: 4.307 ± 0.055	1.148ThrHis: 1.148 ± 0.024	3.306ThrIle: 3.306 ± 0.033	3.262ThrLys: 3.262 ± 0.041	4.921ThrLeu: 4.921 ± 0.049	1.177ThrMet: 1.177 ± 0.023	2.17ThrAsn: 2.17 ± 0.03	4.14ThrPro: 4.14 ± 0.059	2.044ThrGln: 2.044 ± 0.028	2.922ThrArg: 2.922 ± 0.035	5.096ThrSer: 5.096 ± 0.057	4.321ThrThr: 4.321 ± 0.06	3.706ThrVal: 3.706 ± 0.044	0.771ThrTrp: 0.771 ± 0.017	1.608ThrTyr: 1.608 ± 0.023	0.0ThrXaa: 0.0 ± 0.0
Val	5.424ValAla: 5.424 ± 0.049	0.724ValCys: 0.724 ± 0.018	4.021ValAsp: 4.021 ± 0.041	4.81ValGlu: 4.81 ± 0.05	2.407ValPhe: 2.407 ± 0.034	4.453ValGly: 4.453 ± 0.042	1.285ValHis: 1.285 ± 0.022	3.128ValIle: 3.128 ± 0.036	3.781ValLys: 3.781 ± 0.038	5.278ValLeu: 5.278 ± 0.051	1.491ValMet: 1.491 ± 0.02	2.397ValAsn: 2.397 ± 0.03	3.4ValPro: 3.4 ± 0.038	2.323ValGln: 2.323 ± 0.033	3.202ValArg: 3.202 ± 0.041	4.269ValSer: 4.269 ± 0.04	3.569ValThr: 3.569 ± 0.041	4.663ValVal: 4.663 ± 0.051	0.815ValTrp: 0.815 ± 0.019	1.688ValTyr: 1.688 ± 0.027	0.001ValXaa: 0.001 ± 0.0
Trp	1.012TrpAla: 1.012 ± 0.023	0.154TrpCys: 0.154 ± 0.007	0.899TrpAsp: 0.899 ± 0.021	0.899TrpGlu: 0.899 ± 0.018	0.49TrpPhe: 0.49 ± 0.012	0.978TrpGly: 0.978 ± 0.024	0.286TrpHis: 0.286 ± 0.01	0.713TrpIle: 0.713 ± 0.017	0.905TrpLys: 0.905 ± 0.019	1.14TrpLeu: 1.14 ± 0.021	0.326TrpMet: 0.326 ± 0.012	0.625TrpAsn: 0.625 ± 0.015	0.498TrpPro: 0.498 ± 0.015	0.527TrpGln: 0.527 ± 0.015	0.786TrpArg: 0.786 ± 0.018	0.902TrpSer: 0.902 ± 0.018	0.814TrpThr: 0.814 ± 0.018	0.825TrpVal: 0.825 ± 0.017	0.243TrpTrp: 0.243 ± 0.01	0.383TrpTyr: 0.383 ± 0.013	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.069TyrAla: 2.069 ± 0.03	0.332TyrCys: 0.332 ± 0.011	1.737TyrAsp: 1.737 ± 0.028	1.782TyrGlu: 1.782 ± 0.028	1.155TyrPhe: 1.155 ± 0.021	2.125TyrGly: 2.125 ± 0.032	0.664TyrHis: 0.664 ± 0.017	1.404TyrIle: 1.404 ± 0.024	1.35TyrLys: 1.35 ± 0.024	2.476TyrLeu: 2.476 ± 0.033	0.637TyrMet: 0.637 ± 0.018	1.182TyrAsn: 1.182 ± 0.019	1.343TyrPro: 1.343 ± 0.022	1.053TyrGln: 1.053 ± 0.019	1.383TyrArg: 1.383 ± 0.025	1.786TyrSer: 1.786 ± 0.03	1.636TyrThr: 1.636 ± 0.027	1.625TyrVal: 1.625 ± 0.025	0.402TyrTrp: 0.402 ± 0.014	0.892TyrTyr: 0.892 ± 0.022	0.001TyrXaa: 0.001 ± 0.001
Xaa	0.001XaaAla: 0.001 ± 0.001	0.0XaaCys: 0.0 ± 0.0	0.001XaaAsp: 0.001 ± 0.001	0.001XaaGlu: 0.001 ± 0.001	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.001XaaPro: 0.001 ± 0.001	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.001XaaSer: 0.001 ± 0.001	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 7926 proteins (2715168 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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