Amino acid dipepetide frequency for Ketogulonicigenium robustum

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
19.968AlaAla: 19.968 ± 0.28
0.865AlaCys: 0.865 ± 0.039
7.927AlaAsp: 7.927 ± 0.1
7.188AlaGlu: 7.188 ± 0.112
4.498AlaPhe: 4.498 ± 0.083
11.369AlaGly: 11.369 ± 0.138
2.447AlaHis: 2.447 ± 0.057
6.655AlaIle: 6.655 ± 0.096
3.371AlaLys: 3.371 ± 0.074
15.511AlaLeu: 15.511 ± 0.161
3.977AlaMet: 3.977 ± 0.073
3.01AlaAsn: 3.01 ± 0.061
6.6AlaPro: 6.6 ± 0.126
5.498AlaGln: 5.498 ± 0.115
9.309AlaArg: 9.309 ± 0.131
5.646AlaSer: 5.646 ± 0.089
6.821AlaThr: 6.821 ± 0.105
8.957AlaVal: 8.957 ± 0.127
1.552AlaTrp: 1.552 ± 0.05
2.583AlaTyr: 2.583 ± 0.065
0.0AlaXaa: 0.0 ± 0.0
Cys
0.955CysAla: 0.955 ± 0.038
0.089CysCys: 0.089 ± 0.014
0.467CysAsp: 0.467 ± 0.025
0.271CysGlu: 0.271 ± 0.018
0.263CysPhe: 0.263 ± 0.017
0.779CysGly: 0.779 ± 0.031
0.228CysHis: 0.228 ± 0.018
0.369CysIle: 0.369 ± 0.021
0.151CysLys: 0.151 ± 0.013
0.669CysLeu: 0.669 ± 0.033
0.129CysMet: 0.129 ± 0.013
0.182CysAsn: 0.182 ± 0.015
0.409CysPro: 0.409 ± 0.026
0.216CysGln: 0.216 ± 0.017
0.452CysArg: 0.452 ± 0.025
0.34CysSer: 0.34 ± 0.022
0.417CysThr: 0.417 ± 0.023
0.518CysVal: 0.518 ± 0.022
0.089CysTrp: 0.089 ± 0.011
0.152CysTyr: 0.152 ± 0.014
0.0CysXaa: 0.0 ± 0.0
Asp
7.67AspAla: 7.67 ± 0.108
0.395AspCys: 0.395 ± 0.022
3.435AspAsp: 3.435 ± 0.077
3.159AspGlu: 3.159 ± 0.063
2.334AspPhe: 2.334 ± 0.053
5.455AspGly: 5.455 ± 0.098
1.195AspHis: 1.195 ± 0.04
3.187AspIle: 3.187 ± 0.068
1.499AspLys: 1.499 ± 0.047
6.487AspLeu: 6.487 ± 0.104
1.742AspMet: 1.742 ± 0.046
1.391AspAsn: 1.391 ± 0.043
3.51AspPro: 3.51 ± 0.064
1.933AspGln: 1.933 ± 0.052
3.845AspArg: 3.845 ± 0.088
2.383AspSer: 2.383 ± 0.056
3.021AspThr: 3.021 ± 0.069
4.49AspVal: 4.49 ± 0.078
1.059AspTrp: 1.059 ± 0.035
1.638AspTyr: 1.638 ± 0.047
0.0AspXaa: 0.0 ± 0.0
Glu
6.793GluAla: 6.793 ± 0.106
0.276GluCys: 0.276 ± 0.018
2.696GluAsp: 2.696 ± 0.057
2.549GluGlu: 2.549 ± 0.068
1.514GluPhe: 1.514 ± 0.043
4.276GluGly: 4.276 ± 0.076
0.87GluHis: 0.87 ± 0.036
3.012GluIle: 3.012 ± 0.056
1.692GluLys: 1.692 ± 0.054
4.066GluLeu: 4.066 ± 0.08
1.604GluMet: 1.604 ± 0.043
1.636GluAsn: 1.636 ± 0.05
1.891GluPro: 1.891 ± 0.054
1.677GluGln: 1.677 ± 0.044
3.294GluArg: 3.294 ± 0.078
2.218GluSer: 2.218 ± 0.056
3.1GluThr: 3.1 ± 0.064
4.093GluVal: 4.093 ± 0.083
0.645GluTrp: 0.645 ± 0.031
0.941GluTyr: 0.941 ± 0.036
0.0GluXaa: 0.0 ± 0.0
Phe
4.702PheAla: 4.702 ± 0.088
0.355PheCys: 0.355 ± 0.021
2.742PheAsp: 2.742 ± 0.063
1.768PheGlu: 1.768 ± 0.043
1.345PhePhe: 1.345 ± 0.046
3.681PheGly: 3.681 ± 0.075
0.679PheHis: 0.679 ± 0.03
1.8PheIle: 1.8 ± 0.052
0.839PheLys: 0.839 ± 0.038
3.221PheLeu: 3.221 ± 0.067
0.863PheMet: 0.863 ± 0.036
1.141PheAsn: 1.141 ± 0.038
1.552PhePro: 1.552 ± 0.038
1.082PheGln: 1.082 ± 0.036
2.038PheArg: 2.038 ± 0.05
2.078PheSer: 2.078 ± 0.057
2.296PheThr: 2.296 ± 0.053
2.72PheVal: 2.72 ± 0.06
0.574PheTrp: 0.574 ± 0.03
0.86PheTyr: 0.86 ± 0.041
0.0PheXaa: 0.0 ± 0.0
Gly
10.654GlyAla: 10.654 ± 0.147
0.717GlyCys: 0.717 ± 0.029
4.62GlyAsp: 4.62 ± 0.082
4.129GlyGlu: 4.129 ± 0.077
3.646GlyPhe: 3.646 ± 0.071
7.209GlyGly: 7.209 ± 0.118
1.872GlyHis: 1.872 ± 0.052
4.359GlyIle: 4.359 ± 0.082
2.943GlyLys: 2.943 ± 0.071
9.316GlyLeu: 9.316 ± 0.107
2.453GlyMet: 2.453 ± 0.058
2.155GlyAsn: 2.155 ± 0.058
3.689GlyPro: 3.689 ± 0.065
3.599GlyGln: 3.599 ± 0.072
5.706GlyArg: 5.706 ± 0.083
3.842GlySer: 3.842 ± 0.069
4.836GlyThr: 4.836 ± 0.089
6.564GlyVal: 6.564 ± 0.101
1.387GlyTrp: 1.387 ± 0.046
2.198GlyTyr: 2.198 ± 0.046
0.0GlyXaa: 0.0 ± 0.0
His
2.379HisAla: 2.379 ± 0.06
0.191HisCys: 0.191 ± 0.016
1.351HisAsp: 1.351 ± 0.045
0.901HisGlu: 0.901 ± 0.033
0.869HisPhe: 0.869 ± 0.032
1.799HisGly: 1.799 ± 0.048
0.559HisHis: 0.559 ± 0.029
1.148HisIle: 1.148 ± 0.039
0.428HisLys: 0.428 ± 0.023
2.055HisLeu: 2.055 ± 0.048
0.555HisMet: 0.555 ± 0.026
0.451HisAsn: 0.451 ± 0.028
1.324HisPro: 1.324 ± 0.046
0.619HisGln: 0.619 ± 0.028
1.274HisArg: 1.274 ± 0.043
0.909HisSer: 0.909 ± 0.03
0.916HisThr: 0.916 ± 0.037
1.421HisVal: 1.421 ± 0.043
0.311HisTrp: 0.311 ± 0.02
0.555HisTyr: 0.555 ± 0.025
0.0HisXaa: 0.0 ± 0.0
Ile
7.971IleAla: 7.971 ± 0.107
0.56IleCys: 0.56 ± 0.024
3.722IleAsp: 3.722 ± 0.072
3.095IleGlu: 3.095 ± 0.07
1.793IlePhe: 1.793 ± 0.058
5.065IleGly: 5.065 ± 0.099
0.896IleHis: 0.896 ± 0.035
2.539IleIle: 2.539 ± 0.058
1.266IleLys: 1.266 ± 0.046
4.69IleLeu: 4.69 ± 0.074
1.253IleMet: 1.253 ± 0.045
1.416IleAsn: 1.416 ± 0.041
2.535IlePro: 2.535 ± 0.054
1.141IleGln: 1.141 ± 0.038
3.109IleArg: 3.109 ± 0.069
3.076IleSer: 3.076 ± 0.057
3.27IleThr: 3.27 ± 0.064
3.858IleVal: 3.858 ± 0.07
0.698IleTrp: 0.698 ± 0.03
1.179IleTyr: 1.179 ± 0.037
0.0IleXaa: 0.0 ± 0.0
Lys
3.517LysAla: 3.517 ± 0.076
0.135LysCys: 0.135 ± 0.013
1.429LysAsp: 1.429 ± 0.049
1.048LysGlu: 1.048 ± 0.039
0.79LysPhe: 0.79 ± 0.033
2.275LysGly: 2.275 ± 0.054
0.476LysHis: 0.476 ± 0.025
1.546LysIle: 1.546 ± 0.049
0.932LysLys: 0.932 ± 0.048
2.663LysLeu: 2.663 ± 0.075
0.86LysMet: 0.86 ± 0.033
0.698LysAsn: 0.698 ± 0.03
1.527LysPro: 1.527 ± 0.054
0.802LysGln: 0.802 ± 0.034
1.769LysArg: 1.769 ± 0.045
1.522LysSer: 1.522 ± 0.045
1.683LysThr: 1.683 ± 0.049
2.1LysVal: 2.1 ± 0.054
0.358LysTrp: 0.358 ± 0.023
0.539LysTyr: 0.539 ± 0.025
0.0LysXaa: 0.0 ± 0.0
Leu
13.764LeuAla: 13.764 ± 0.174
0.767LeuCys: 0.767 ± 0.033
5.958LeuAsp: 5.958 ± 0.098
4.351LeuGlu: 4.351 ± 0.082
3.367LeuPhe: 3.367 ± 0.071
8.498LeuGly: 8.498 ± 0.098
2.168LeuHis: 2.168 ± 0.056
5.182LeuIle: 5.182 ± 0.087
2.66LeuLys: 2.66 ± 0.069
9.584LeuLeu: 9.584 ± 0.137
2.803LeuMet: 2.803 ± 0.064
2.805LeuAsn: 2.805 ± 0.068
6.208LeuPro: 6.208 ± 0.102
3.843LeuGln: 3.843 ± 0.068
7.786LeuArg: 7.786 ± 0.115
6.295LeuSer: 6.295 ± 0.093
6.139LeuThr: 6.139 ± 0.104
7.142LeuVal: 7.142 ± 0.108
1.278LeuTrp: 1.278 ± 0.045
1.976LeuTyr: 1.976 ± 0.052
0.0LeuXaa: 0.0 ± 0.0
Met
3.831MetAla: 3.831 ± 0.073
0.148MetCys: 0.148 ± 0.014
1.414MetAsp: 1.414 ± 0.042
1.159MetGlu: 1.159 ± 0.042
0.817MetPhe: 0.817 ± 0.031
2.349MetGly: 2.349 ± 0.055
0.454MetHis: 0.454 ± 0.022
1.659MetIle: 1.659 ± 0.05
0.92MetLys: 0.92 ± 0.034
2.716MetLeu: 2.716 ± 0.064
0.806MetMet: 0.806 ± 0.03
0.874MetAsn: 0.874 ± 0.032
1.617MetPro: 1.617 ± 0.046
1.118MetGln: 1.118 ± 0.041
2.026MetArg: 2.026 ± 0.054
1.431MetSer: 1.431 ± 0.043
2.13MetThr: 2.13 ± 0.051
1.928MetVal: 1.928 ± 0.05
0.214MetTrp: 0.214 ± 0.016
0.352MetTyr: 0.352 ± 0.022
0.0MetXaa: 0.0 ± 0.0
Asn
3.513AsnAla: 3.513 ± 0.075
0.2AsnCys: 0.2 ± 0.016
1.462AsnAsp: 1.462 ± 0.042
1.017AsnGlu: 1.017 ± 0.038
1.005AsnPhe: 1.005 ± 0.039
2.456AsnGly: 2.456 ± 0.059
0.524AsnHis: 0.524 ± 0.024
1.501AsnIle: 1.501 ± 0.045
0.58AsnLys: 0.58 ± 0.026
2.579AsnLeu: 2.579 ± 0.063
0.762AsnMet: 0.762 ± 0.033
0.656AsnAsn: 0.656 ± 0.029
2.079AsnPro: 2.079 ± 0.057
0.774AsnGln: 0.774 ± 0.03
1.714AsnArg: 1.714 ± 0.049
1.204AsnSer: 1.204 ± 0.041
1.485AsnThr: 1.485 ± 0.044
1.915AsnVal: 1.915 ± 0.06
0.429AsnTrp: 0.429 ± 0.023
0.741AsnTyr: 0.741 ± 0.034
0.0AsnXaa: 0.0 ± 0.0
Pro
7.505ProAla: 7.505 ± 0.13
0.304ProCys: 0.304 ± 0.02
3.878ProAsp: 3.878 ± 0.085
3.477ProGlu: 3.477 ± 0.068
1.985ProPhe: 1.985 ± 0.052
3.616ProGly: 3.616 ± 0.068
1.202ProHis: 1.202 ± 0.041
2.329ProIle: 2.329 ± 0.062
1.36ProLys: 1.36 ± 0.044
5.1ProLeu: 5.1 ± 0.093
1.237ProMet: 1.237 ± 0.038
1.421ProAsn: 1.421 ± 0.045
2.564ProPro: 2.564 ± 0.076
2.119ProGln: 2.119 ± 0.06
3.108ProArg: 3.108 ± 0.081
2.551ProSer: 2.551 ± 0.053
2.918ProThr: 2.918 ± 0.072
4.349ProVal: 4.349 ± 0.072
0.672ProTrp: 0.672 ± 0.028
1.219ProTyr: 1.219 ± 0.041
0.0ProXaa: 0.0 ± 0.0
Gln
4.526GlnAla: 4.526 ± 0.076
0.159GlnCys: 0.159 ± 0.013
1.902GlnAsp: 1.902 ± 0.046
1.26GlnGlu: 1.26 ± 0.044
1.124GlnPhe: 1.124 ± 0.041
2.985GlnGly: 2.985 ± 0.062
0.72GlnHis: 0.72 ± 0.03
2.445GlnIle: 2.445 ± 0.055
0.998GlnLys: 0.998 ± 0.041
3.414GlnLeu: 3.414 ± 0.07
1.302GlnMet: 1.302 ± 0.043
1.163GlnAsn: 1.163 ± 0.037
2.098GlnPro: 2.098 ± 0.052
1.38GlnGln: 1.38 ± 0.049
2.844GlnArg: 2.844 ± 0.073
1.926GlnSer: 1.926 ± 0.048
2.091GlnThr: 2.091 ± 0.054
2.612GlnVal: 2.612 ± 0.06
0.44GlnTrp: 0.44 ± 0.025
0.588GlnTyr: 0.588 ± 0.028
0.0GlnXaa: 0.0 ± 0.0
Arg
8.875ArgAla: 8.875 ± 0.129
0.383ArgCys: 0.383 ± 0.024
4.071ArgAsp: 4.071 ± 0.079
3.315ArgGlu: 3.315 ± 0.077
2.611ArgPhe: 2.611 ± 0.052
4.853ArgGly: 4.853 ± 0.081
1.457ArgHis: 1.457 ± 0.042
3.919ArgIle: 3.919 ± 0.074
2.021ArgLys: 2.021 ± 0.056
7.158ArgLeu: 7.158 ± 0.114
1.995ArgMet: 1.995 ± 0.052
1.868ArgAsn: 1.868 ± 0.049
3.317ArgPro: 3.317 ± 0.069
2.582ArgGln: 2.582 ± 0.065
4.684ArgArg: 4.684 ± 0.085
2.939ArgSer: 2.939 ± 0.063
3.141ArgThr: 3.141 ± 0.062
4.846ArgVal: 4.846 ± 0.076
0.902ArgTrp: 0.902 ± 0.033
1.526ArgTyr: 1.526 ± 0.048
0.0ArgXaa: 0.0 ± 0.0
Ser
6.097SerAla: 6.097 ± 0.09
0.384SerCys: 0.384 ± 0.025
2.898SerAsp: 2.898 ± 0.061
2.208SerGlu: 2.208 ± 0.055
2.126SerPhe: 2.126 ± 0.052
5.098SerGly: 5.098 ± 0.078
1.026SerHis: 1.026 ± 0.034
2.466SerIle: 2.466 ± 0.061
1.121SerLys: 1.121 ± 0.041
5.106SerLeu: 5.106 ± 0.097
1.204SerMet: 1.204 ± 0.042
1.271SerAsn: 1.271 ± 0.049
2.645SerPro: 2.645 ± 0.051
1.727SerGln: 1.727 ± 0.05
3.102SerArg: 3.102 ± 0.068
2.38SerSer: 2.38 ± 0.061
2.567SerThr: 2.567 ± 0.065
3.709SerVal: 3.709 ± 0.076
0.73SerTrp: 0.73 ± 0.035
1.369SerTyr: 1.369 ± 0.041
0.0SerXaa: 0.0 ± 0.0
Thr
7.072ThrAla: 7.072 ± 0.105
0.402ThrCys: 0.402 ± 0.022
3.138ThrAsp: 3.138 ± 0.067
2.421ThrGlu: 2.421 ± 0.055
2.162ThrPhe: 2.162 ± 0.048
5.394ThrGly: 5.394 ± 0.081
1.193ThrHis: 1.193 ± 0.042
3.103ThrIle: 3.103 ± 0.061
1.211ThrLys: 1.211 ± 0.045
6.581ThrLeu: 6.581 ± 0.097
1.26ThrMet: 1.26 ± 0.038
1.382ThrAsn: 1.382 ± 0.045
3.89ThrPro: 3.89 ± 0.086
1.873ThrGln: 1.873 ± 0.053
3.593ThrArg: 3.593 ± 0.072
2.746ThrSer: 2.746 ± 0.059
3.238ThrThr: 3.238 ± 0.07
4.397ThrVal: 4.397 ± 0.076
0.638ThrTrp: 0.638 ± 0.027
1.286ThrTyr: 1.286 ± 0.044
0.0ThrXaa: 0.0 ± 0.0
Val
9.858ValAla: 9.858 ± 0.134
0.51ValCys: 0.51 ± 0.021
4.318ValAsp: 4.318 ± 0.084
3.894ValGlu: 3.894 ± 0.082
2.748ValPhe: 2.748 ± 0.064
5.715ValGly: 5.715 ± 0.099
1.231ValHis: 1.231 ± 0.04
4.319ValIle: 4.319 ± 0.08
1.819ValLys: 1.819 ± 0.055
7.815ValLeu: 7.815 ± 0.123
2.305ValMet: 2.305 ± 0.055
2.048ValAsn: 2.048 ± 0.065
3.645ValPro: 3.645 ± 0.076
2.491ValGln: 2.491 ± 0.055
4.236ValArg: 4.236 ± 0.08
3.919ValSer: 3.919 ± 0.069
4.967ValThr: 4.967 ± 0.084
5.979ValVal: 5.979 ± 0.101
0.932ValTrp: 0.932 ± 0.038
1.474ValTyr: 1.474 ± 0.046
0.0ValXaa: 0.0 ± 0.0
Trp
1.467TrpAla: 1.467 ± 0.047
0.114TrpCys: 0.114 ± 0.012
0.748TrpAsp: 0.748 ± 0.034
0.536TrpGlu: 0.536 ± 0.027
0.475TrpPhe: 0.475 ± 0.028
1.005TrpGly: 1.005 ± 0.037
0.333TrpHis: 0.333 ± 0.02
0.622TrpIle: 0.622 ± 0.025
0.345TrpLys: 0.345 ± 0.02
1.629TrpLeu: 1.629 ± 0.043
0.412TrpMet: 0.412 ± 0.023
0.4TrpAsn: 0.4 ± 0.02
0.72TrpPro: 0.72 ± 0.03
0.723TrpGln: 0.723 ± 0.027
1.112TrpArg: 1.112 ± 0.044
0.682TrpSer: 0.682 ± 0.03
0.676TrpThr: 0.676 ± 0.03
1.009TrpVal: 1.009 ± 0.038
0.229TrpTrp: 0.229 ± 0.018
0.259TrpTyr: 0.259 ± 0.017
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.633TyrAla: 2.633 ± 0.061
0.193TyrCys: 0.193 ± 0.016
1.651TyrAsp: 1.651 ± 0.042
1.1TyrGlu: 1.1 ± 0.038
0.864TyrPhe: 0.864 ± 0.038
2.018TyrGly: 2.018 ± 0.057
0.483TyrHis: 0.483 ± 0.026
0.972TyrIle: 0.972 ± 0.034
0.516TyrLys: 0.516 ± 0.028
2.215TyrLeu: 2.215 ± 0.057
0.439TyrMet: 0.439 ± 0.027
0.629TyrAsn: 0.629 ± 0.024
1.093TyrPro: 1.093 ± 0.039
0.782TyrGln: 0.782 ± 0.032
1.462TyrArg: 1.462 ± 0.048
1.149TyrSer: 1.149 ± 0.038
1.266TyrThr: 1.266 ± 0.036
1.614TyrVal: 1.614 ± 0.043
0.356TyrTrp: 0.356 ± 0.023
0.534TyrTyr: 0.534 ± 0.024
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2662 proteins (806659 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski