Amino acid dipepetide frequency for Bat coronavirus 133/2005 (BtCoV) (BtCoV/133/2005)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.57AlaAla: 5.57 ± 0.699
3.063AlaCys: 3.063 ± 0.757
2.576AlaAsp: 2.576 ± 0.385
1.949AlaGlu: 1.949 ± 0.325
2.924AlaPhe: 2.924 ± 0.462
3.899AlaGly: 3.899 ± 0.343
1.253AlaHis: 1.253 ± 0.374
4.317AlaIle: 4.317 ± 1.127
3.62AlaLys: 3.62 ± 0.638
6.614AlaLeu: 6.614 ± 0.835
2.019AlaMet: 2.019 ± 0.374
5.709AlaAsn: 5.709 ± 0.542
2.437AlaPro: 2.437 ± 0.732
2.228AlaGln: 2.228 ± 0.325
2.576AlaArg: 2.576 ± 0.31
5.57AlaSer: 5.57 ± 0.6
5.083AlaThr: 5.083 ± 0.78
5.083AlaVal: 5.083 ± 0.401
0.766AlaTrp: 0.766 ± 0.168
3.69AlaTyr: 3.69 ± 0.364
0.0AlaXaa: 0.0 ± 0.0
Cys
1.671CysAla: 1.671 ± 0.552
0.905CysCys: 0.905 ± 0.227
1.949CysAsp: 1.949 ± 0.206
0.696CysGlu: 0.696 ± 0.281
1.044CysPhe: 1.044 ± 0.21
2.785CysGly: 2.785 ± 0.472
0.348CysHis: 0.348 ± 0.14
1.532CysIle: 1.532 ± 0.156
2.228CysLys: 2.228 ± 0.303
2.576CysLeu: 2.576 ± 0.245
0.209CysMet: 0.209 ± 0.133
1.671CysAsn: 1.671 ± 0.391
0.975CysPro: 0.975 ± 0.172
0.835CysGln: 0.835 ± 0.117
1.044CysArg: 1.044 ± 0.215
2.019CysSer: 2.019 ± 0.366
2.715CysThr: 2.715 ± 0.29
3.272CysVal: 3.272 ± 0.363
0.209CysTrp: 0.209 ± 0.133
2.019CysTyr: 2.019 ± 0.486
0.0CysXaa: 0.0 ± 0.0
Asp
4.734AspAla: 4.734 ± 0.637
2.089AspCys: 2.089 ± 0.382
2.506AspAsp: 2.506 ± 0.398
2.367AspGlu: 2.367 ± 0.402
2.298AspPhe: 2.298 ± 0.592
4.386AspGly: 4.386 ± 0.231
0.835AspHis: 0.835 ± 0.228
3.62AspIle: 3.62 ± 0.688
2.019AspLys: 2.019 ± 0.219
5.291AspLeu: 5.291 ± 0.662
1.462AspMet: 1.462 ± 0.217
2.158AspAsn: 2.158 ± 0.239
2.437AspPro: 2.437 ± 0.345
0.975AspGln: 0.975 ± 0.296
1.532AspArg: 1.532 ± 0.442
3.342AspSer: 3.342 ± 0.364
2.855AspThr: 2.855 ± 0.284
6.196AspVal: 6.196 ± 1.261
0.627AspTrp: 0.627 ± 0.355
2.924AspTyr: 2.924 ± 0.353
0.0AspXaa: 0.0 ± 0.0
Glu
2.715GluAla: 2.715 ± 0.401
1.114GluCys: 1.114 ± 0.325
2.994GluAsp: 2.994 ± 0.427
2.228GluGlu: 2.228 ± 0.239
2.158GluPhe: 2.158 ± 0.375
1.323GluGly: 1.323 ± 0.214
1.323GluHis: 1.323 ± 0.201
1.671GluIle: 1.671 ± 0.259
1.81GluLys: 1.81 ± 0.259
3.203GluLeu: 3.203 ± 0.297
0.278GluMet: 0.278 ± 0.25
1.81GluAsn: 1.81 ± 0.235
1.323GluPro: 1.323 ± 0.245
1.323GluGln: 1.323 ± 0.369
1.323GluArg: 1.323 ± 0.394
2.576GluSer: 2.576 ± 0.406
3.412GluThr: 3.412 ± 0.525
3.62GluVal: 3.62 ± 0.653
0.835GluTrp: 0.835 ± 0.339
1.81GluTyr: 1.81 ± 0.539
0.0GluXaa: 0.0 ± 0.0
Phe
2.924PheAla: 2.924 ± 0.622
1.323PheCys: 1.323 ± 0.235
2.576PheAsp: 2.576 ± 0.486
1.88PheGlu: 1.88 ± 0.231
2.089PhePhe: 2.089 ± 0.597
2.367PheGly: 2.367 ± 0.493
0.278PheHis: 0.278 ± 0.331
3.76PheIle: 3.76 ± 0.264
2.785PheLys: 2.785 ± 0.543
4.665PheLeu: 4.665 ± 0.9
0.696PheMet: 0.696 ± 0.287
3.272PheAsn: 3.272 ± 0.339
1.044PhePro: 1.044 ± 0.462
1.253PheGln: 1.253 ± 0.22
1.741PheArg: 1.741 ± 0.214
3.829PheSer: 3.829 ± 1.042
2.994PheThr: 2.994 ± 0.522
5.709PheVal: 5.709 ± 0.507
0.487PheTrp: 0.487 ± 0.17
2.785PheTyr: 2.785 ± 0.364
0.0PheXaa: 0.0 ± 0.0
Gly
3.829GlyAla: 3.829 ± 0.465
1.949GlyCys: 1.949 ± 0.347
4.108GlyAsp: 4.108 ± 0.577
1.462GlyGlu: 1.462 ± 0.31
3.133GlyPhe: 3.133 ± 0.813
4.317GlyGly: 4.317 ± 0.338
1.253GlyHis: 1.253 ± 0.253
2.785GlyIle: 2.785 ± 0.216
3.62GlyLys: 3.62 ± 0.537
5.152GlyLeu: 5.152 ± 0.54
1.114GlyMet: 1.114 ± 0.553
2.437GlyAsn: 2.437 ± 0.873
1.671GlyPro: 1.671 ± 0.31
1.462GlyGln: 1.462 ± 0.21
1.323GlyArg: 1.323 ± 0.604
4.108GlySer: 4.108 ± 0.439
4.734GlyThr: 4.734 ± 0.802
7.31GlyVal: 7.31 ± 0.716
0.348GlyTrp: 0.348 ± 0.106
2.924GlyTyr: 2.924 ± 0.615
0.0GlyXaa: 0.0 ± 0.0
His
1.323HisAla: 1.323 ± 0.382
0.348HisCys: 0.348 ± 0.323
0.696HisAsp: 0.696 ± 0.156
0.209HisGlu: 0.209 ± 0.162
0.975HisPhe: 0.975 ± 0.361
1.462HisGly: 1.462 ± 0.251
0.0HisHis: 0.0 ± 0.0
1.462HisIle: 1.462 ± 0.181
0.766HisLys: 0.766 ± 0.214
2.019HisLeu: 2.019 ± 0.344
0.418HisMet: 0.418 ± 0.148
0.975HisAsn: 0.975 ± 0.205
0.696HisPro: 0.696 ± 0.175
0.766HisGln: 0.766 ± 0.21
0.905HisArg: 0.905 ± 0.267
1.81HisSer: 1.81 ± 0.189
1.81HisThr: 1.81 ± 0.387
1.741HisVal: 1.741 ± 0.252
0.418HisTrp: 0.418 ± 0.097
0.696HisTyr: 0.696 ± 0.252
0.0HisXaa: 0.0 ± 0.0
Ile
3.342IleAla: 3.342 ± 0.344
1.044IleCys: 1.044 ± 0.268
2.506IleAsp: 2.506 ± 0.381
2.158IleGlu: 2.158 ± 0.296
1.741IlePhe: 1.741 ± 0.814
2.715IleGly: 2.715 ± 0.344
0.905IleHis: 0.905 ± 0.287
1.323IleIle: 1.323 ± 1.295
2.646IleLys: 2.646 ± 0.296
5.013IleLeu: 5.013 ± 0.662
1.184IleMet: 1.184 ± 0.355
3.342IleAsn: 3.342 ± 0.449
2.506IlePro: 2.506 ± 0.343
1.392IleGln: 1.392 ± 0.271
1.532IleArg: 1.532 ± 0.586
3.76IleSer: 3.76 ± 0.479
3.063IleThr: 3.063 ± 0.735
5.361IleVal: 5.361 ± 0.731
0.348IleTrp: 0.348 ± 0.092
1.949IleTyr: 1.949 ± 0.281
0.0IleXaa: 0.0 ± 0.0
Lys
3.899LysAla: 3.899 ± 0.403
1.184LysCys: 1.184 ± 0.257
2.924LysAsp: 2.924 ± 0.563
2.298LysGlu: 2.298 ± 0.32
2.994LysPhe: 2.994 ± 0.406
2.855LysGly: 2.855 ± 0.53
2.228LysHis: 2.228 ± 0.536
2.228LysIle: 2.228 ± 0.348
2.646LysLys: 2.646 ± 0.507
6.545LysLeu: 6.545 ± 0.737
1.671LysMet: 1.671 ± 0.707
2.367LysAsn: 2.367 ± 0.464
3.76LysPro: 3.76 ± 0.579
2.019LysGln: 2.019 ± 0.423
2.158LysArg: 2.158 ± 0.42
2.019LysSer: 2.019 ± 0.406
2.924LysThr: 2.924 ± 0.447
3.76LysVal: 3.76 ± 0.484
0.696LysTrp: 0.696 ± 0.167
2.646LysTyr: 2.646 ± 0.718
0.0LysXaa: 0.0 ± 0.0
Leu
7.519LeuAla: 7.519 ± 1.027
3.969LeuCys: 3.969 ± 0.373
3.829LeuAsp: 3.829 ± 0.526
4.038LeuGlu: 4.038 ± 0.479
5.848LeuPhe: 5.848 ± 0.69
4.456LeuGly: 4.456 ± 0.939
2.785LeuHis: 2.785 ± 0.525
3.551LeuIle: 3.551 ± 0.329
4.874LeuLys: 4.874 ± 0.776
9.747LeuLeu: 9.747 ± 1.438
1.392LeuMet: 1.392 ± 0.319
4.804LeuAsn: 4.804 ± 0.341
3.829LeuPro: 3.829 ± 0.378
4.386LeuGln: 4.386 ± 0.476
4.595LeuArg: 4.595 ± 0.846
6.545LeuSer: 6.545 ± 0.425
7.798LeuThr: 7.798 ± 0.577
6.893LeuVal: 6.893 ± 0.648
1.323LeuTrp: 1.323 ± 0.532
3.899LeuTyr: 3.899 ± 0.519
0.0LeuXaa: 0.0 ± 0.0
Met
1.114MetAla: 1.114 ± 0.64
0.975MetCys: 0.975 ± 0.285
0.557MetAsp: 0.557 ± 0.151
1.044MetGlu: 1.044 ± 0.36
1.253MetPhe: 1.253 ± 0.269
0.975MetGly: 0.975 ± 0.187
0.905MetHis: 0.905 ± 0.271
0.627MetIle: 0.627 ± 0.123
1.044MetLys: 1.044 ± 0.276
3.272MetLeu: 3.272 ± 0.635
0.766MetMet: 0.766 ± 0.252
0.835MetAsn: 0.835 ± 0.237
0.835MetPro: 0.835 ± 0.247
1.114MetGln: 1.114 ± 0.253
0.975MetArg: 0.975 ± 0.403
1.949MetSer: 1.949 ± 0.557
1.184MetThr: 1.184 ± 0.176
1.392MetVal: 1.392 ± 0.75
0.348MetTrp: 0.348 ± 0.25
1.323MetTyr: 1.323 ± 0.359
0.0MetXaa: 0.0 ± 0.0
Asn
4.177AsnAla: 4.177 ± 0.307
1.88AsnCys: 1.88 ± 0.286
3.133AsnAsp: 3.133 ± 0.319
2.506AsnGlu: 2.506 ± 0.599
2.785AsnPhe: 2.785 ± 0.315
4.665AsnGly: 4.665 ± 0.347
0.696AsnHis: 0.696 ± 0.091
2.437AsnIle: 2.437 ± 0.174
3.133AsnLys: 3.133 ± 0.422
4.456AsnLeu: 4.456 ± 0.652
1.044AsnMet: 1.044 ± 0.223
2.994AsnAsn: 2.994 ± 0.402
2.019AsnPro: 2.019 ± 0.546
1.88AsnGln: 1.88 ± 0.41
1.532AsnArg: 1.532 ± 0.265
4.108AsnSer: 4.108 ± 0.619
2.855AsnThr: 2.855 ± 0.303
4.317AsnVal: 4.317 ± 0.457
0.835AsnTrp: 0.835 ± 0.191
3.342AsnTyr: 3.342 ± 0.48
0.0AsnXaa: 0.0 ± 0.0
Pro
2.298ProAla: 2.298 ± 0.502
1.392ProCys: 1.392 ± 0.276
1.741ProAsp: 1.741 ± 0.289
1.671ProGlu: 1.671 ± 0.489
1.81ProPhe: 1.81 ± 0.411
2.576ProGly: 2.576 ± 0.362
0.487ProHis: 0.487 ± 0.163
2.367ProIle: 2.367 ± 0.42
2.158ProLys: 2.158 ± 0.941
5.291ProLeu: 5.291 ± 1.014
0.975ProMet: 0.975 ± 0.388
2.298ProAsn: 2.298 ± 0.373
1.323ProPro: 1.323 ± 0.78
0.905ProGln: 0.905 ± 0.389
1.601ProArg: 1.601 ± 0.591
2.437ProSer: 2.437 ± 0.621
3.272ProThr: 3.272 ± 0.251
2.576ProVal: 2.576 ± 0.191
0.627ProTrp: 0.627 ± 0.131
1.601ProTyr: 1.601 ± 0.314
0.0ProXaa: 0.0 ± 0.0
Gln
1.81GlnAla: 1.81 ± 0.473
0.905GlnCys: 0.905 ± 0.204
2.019GlnAsp: 2.019 ± 0.509
1.114GlnGlu: 1.114 ± 0.182
1.114GlnPhe: 1.114 ± 0.632
1.462GlnGly: 1.462 ± 0.349
0.418GlnHis: 0.418 ± 0.273
1.462GlnIle: 1.462 ± 0.347
0.975GlnLys: 0.975 ± 0.177
3.133GlnLeu: 3.133 ± 0.37
1.114GlnMet: 1.114 ± 0.313
1.323GlnAsn: 1.323 ± 0.193
1.601GlnPro: 1.601 ± 0.264
1.601GlnGln: 1.601 ± 0.264
0.696GlnArg: 0.696 ± 0.226
2.924GlnSer: 2.924 ± 0.585
2.506GlnThr: 2.506 ± 0.307
2.506GlnVal: 2.506 ± 0.435
0.418GlnTrp: 0.418 ± 0.129
1.462GlnTyr: 1.462 ± 0.384
0.0GlnXaa: 0.0 ± 0.0
Arg
3.272ArgAla: 3.272 ± 0.667
0.766ArgCys: 0.766 ± 0.329
2.576ArgAsp: 2.576 ± 0.362
1.044ArgGlu: 1.044 ± 0.166
1.671ArgPhe: 1.671 ± 0.271
1.949ArgGly: 1.949 ± 0.544
0.905ArgHis: 0.905 ± 0.225
1.253ArgIle: 1.253 ± 0.315
1.949ArgLys: 1.949 ± 0.436
3.551ArgLeu: 3.551 ± 1.118
0.487ArgMet: 0.487 ± 0.148
2.437ArgAsn: 2.437 ± 0.301
1.323ArgPro: 1.323 ± 0.581
1.532ArgGln: 1.532 ± 0.342
1.671ArgArg: 1.671 ± 0.186
2.158ArgSer: 2.158 ± 0.937
2.158ArgThr: 2.158 ± 0.138
3.412ArgVal: 3.412 ± 0.483
0.209ArgTrp: 0.209 ± 0.323
1.81ArgTyr: 1.81 ± 0.33
0.0ArgXaa: 0.0 ± 0.0
Ser
5.083SerAla: 5.083 ± 0.667
1.323SerCys: 1.323 ± 0.191
4.665SerAsp: 4.665 ± 0.504
2.298SerGlu: 2.298 ± 0.379
4.038SerPhe: 4.038 ± 0.675
4.874SerGly: 4.874 ± 0.632
1.253SerHis: 1.253 ± 0.236
2.785SerIle: 2.785 ± 0.714
4.526SerLys: 4.526 ± 0.425
5.779SerLeu: 5.779 ± 1.035
2.158SerMet: 2.158 ± 0.446
3.969SerAsn: 3.969 ± 0.793
1.462SerPro: 1.462 ± 0.515
2.019SerGln: 2.019 ± 0.814
2.855SerArg: 2.855 ± 0.712
7.032SerSer: 7.032 ± 1.088
4.804SerThr: 4.804 ± 0.353
7.867SerVal: 7.867 ± 0.372
1.392SerTrp: 1.392 ± 0.446
3.829SerTyr: 3.829 ± 0.506
0.0SerXaa: 0.0 ± 0.0
Thr
5.709ThrAla: 5.709 ± 0.405
1.044ThrCys: 1.044 ± 0.232
2.506ThrAsp: 2.506 ± 0.385
2.437ThrGlu: 2.437 ± 0.284
3.969ThrPhe: 3.969 ± 0.479
4.734ThrGly: 4.734 ± 0.937
1.253ThrHis: 1.253 ± 0.19
4.247ThrIle: 4.247 ± 0.49
3.203ThrLys: 3.203 ± 0.53
6.057ThrLeu: 6.057 ± 0.481
1.462ThrMet: 1.462 ± 0.225
3.342ThrAsn: 3.342 ± 0.474
3.412ThrPro: 3.412 ± 0.386
1.949ThrGln: 1.949 ± 0.831
2.158ThrArg: 2.158 ± 0.292
5.291ThrSer: 5.291 ± 0.561
4.874ThrThr: 4.874 ± 0.402
7.798ThrVal: 7.798 ± 0.97
0.487ThrTrp: 0.487 ± 0.148
2.785ThrTyr: 2.785 ± 0.475
0.0ThrXaa: 0.0 ± 0.0
Val
6.614ValAla: 6.614 ± 1.001
3.272ValCys: 3.272 ± 0.411
6.196ValAsp: 6.196 ± 0.651
5.639ValGlu: 5.639 ± 1.11
2.785ValPhe: 2.785 ± 0.216
4.665ValGly: 4.665 ± 0.316
1.253ValHis: 1.253 ± 0.311
3.412ValIle: 3.412 ± 0.486
5.709ValLys: 5.709 ± 0.861
9.19ValLeu: 9.19 ± 1.477
2.506ValMet: 2.506 ± 0.489
5.431ValAsn: 5.431 ± 0.512
4.247ValPro: 4.247 ± 0.444
2.298ValGln: 2.298 ± 0.328
3.551ValArg: 3.551 ± 0.276
6.893ValSer: 6.893 ± 0.425
5.918ValThr: 5.918 ± 0.365
8.424ValVal: 8.424 ± 1.095
1.044ValTrp: 1.044 ± 0.185
4.038ValTyr: 4.038 ± 0.327
0.0ValXaa: 0.0 ± 0.0
Trp
0.696TrpAla: 0.696 ± 0.125
0.696TrpCys: 0.696 ± 0.189
0.905TrpAsp: 0.905 ± 0.244
0.278TrpGlu: 0.278 ± 0.101
1.253TrpPhe: 1.253 ± 0.197
0.139TrpGly: 0.139 ± 0.089
0.209TrpHis: 0.209 ± 0.065
0.348TrpIle: 0.348 ± 0.14
0.487TrpLys: 0.487 ± 0.148
1.323TrpLeu: 1.323 ± 0.474
0.139TrpMet: 0.139 ± 0.047
0.696TrpAsn: 0.696 ± 0.253
0.835TrpPro: 0.835 ± 0.32
0.07TrpGln: 0.07 ± 0.126
0.557TrpArg: 0.557 ± 0.162
1.114TrpSer: 1.114 ± 0.503
0.487TrpThr: 0.487 ± 0.123
0.905TrpVal: 0.905 ± 0.186
0.07TrpTrp: 0.07 ± 0.275
0.557TrpTyr: 0.557 ± 0.205
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.646TyrAla: 2.646 ± 0.65
1.462TyrCys: 1.462 ± 0.254
3.69TyrAsp: 3.69 ± 0.41
1.532TyrGlu: 1.532 ± 0.407
2.576TyrPhe: 2.576 ± 0.272
2.437TyrGly: 2.437 ± 0.599
0.975TyrHis: 0.975 ± 0.263
2.646TyrIle: 2.646 ± 0.769
3.62TyrLys: 3.62 ± 0.464
3.203TyrLeu: 3.203 ± 0.59
1.323TyrMet: 1.323 ± 0.297
2.924TyrAsn: 2.924 ± 0.27
1.671TyrPro: 1.671 ± 0.628
0.557TyrGln: 0.557 ± 0.159
1.81TyrArg: 1.81 ± 0.193
4.526TyrSer: 4.526 ± 1.052
3.272TyrThr: 3.272 ± 0.495
4.943TyrVal: 4.943 ± 0.431
0.278TyrTrp: 0.278 ± 0.125
3.063TyrTyr: 3.063 ± 0.433
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 10 proteins (14364 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski