Amino acid dipepetide frequency for Saccharolobus solfataricus rod-shaped virus 1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
0.126AlaAla: 0.126 ± 0.126
0.251AlaCys: 0.251 ± 0.191
2.889AlaAsp: 2.889 ± 0.591
4.27AlaGlu: 4.27 ± 1.152
2.638AlaPhe: 2.638 ± 1.016
3.014AlaGly: 3.014 ± 0.871
0.377AlaHis: 0.377 ± 0.182
8.289AlaIle: 8.289 ± 1.311
5.526AlaLys: 5.526 ± 0.672
6.908AlaLeu: 6.908 ± 0.976
1.13AlaMet: 1.13 ± 0.427
3.14AlaAsn: 3.14 ± 0.457
1.13AlaPro: 1.13 ± 0.344
3.014AlaGln: 3.014 ± 0.69
2.638AlaArg: 2.638 ± 0.412
3.266AlaSer: 3.266 ± 0.555
4.27AlaThr: 4.27 ± 0.641
4.145AlaVal: 4.145 ± 0.768
0.754AlaTrp: 0.754 ± 0.249
4.27AlaTyr: 4.27 ± 1.084
0.0AlaXaa: 0.0 ± 0.0
Cys
0.502CysAla: 0.502 ± 0.265
0.0CysCys: 0.0 ± 0.0
0.377CysAsp: 0.377 ± 0.221
1.13CysGlu: 1.13 ± 0.445
0.0CysPhe: 0.0 ± 0.0
1.005CysGly: 1.005 ± 0.405
0.251CysHis: 0.251 ± 0.306
0.377CysIle: 0.377 ± 0.206
0.879CysLys: 0.879 ± 0.34
0.879CysLeu: 0.879 ± 0.329
0.0CysMet: 0.0 ± 0.0
0.628CysAsn: 0.628 ± 0.296
0.126CysPro: 0.126 ± 0.135
0.377CysGln: 0.377 ± 0.198
0.251CysArg: 0.251 ± 0.197
0.502CysSer: 0.502 ± 0.301
0.377CysThr: 0.377 ± 0.284
0.126CysVal: 0.126 ± 0.126
0.0CysTrp: 0.0 ± 0.0
0.251CysTyr: 0.251 ± 0.199
0.0CysXaa: 0.0 ± 0.0
Asp
3.266AspAla: 3.266 ± 0.682
0.377AspCys: 0.377 ± 0.293
2.01AspAsp: 2.01 ± 0.519
4.773AspGlu: 4.773 ± 0.932
1.256AspPhe: 1.256 ± 0.416
1.256AspGly: 1.256 ± 0.429
0.502AspHis: 0.502 ± 0.209
5.149AspIle: 5.149 ± 0.951
3.893AspLys: 3.893 ± 0.857
5.777AspLeu: 5.777 ± 0.984
0.377AspMet: 0.377 ± 0.24
2.763AspAsn: 2.763 ± 0.446
1.256AspPro: 1.256 ± 0.389
1.758AspGln: 1.758 ± 0.513
2.261AspArg: 2.261 ± 0.559
1.382AspSer: 1.382 ± 0.394
1.382AspThr: 1.382 ± 0.436
3.14AspVal: 3.14 ± 0.542
0.879AspTrp: 0.879 ± 0.347
2.763AspTyr: 2.763 ± 0.564
0.0AspXaa: 0.0 ± 0.0
Glu
3.517GluAla: 3.517 ± 0.718
0.879GluCys: 0.879 ± 0.389
2.512GluAsp: 2.512 ± 0.512
4.773GluGlu: 4.773 ± 1.154
3.517GluPhe: 3.517 ± 0.695
1.884GluGly: 1.884 ± 0.472
0.628GluHis: 0.628 ± 0.261
9.545GluIle: 9.545 ± 1.525
8.541GluLys: 8.541 ± 1.147
5.777GluLeu: 5.777 ± 1.142
2.135GluMet: 2.135 ± 0.595
4.019GluAsn: 4.019 ± 0.688
1.382GluPro: 1.382 ± 0.368
2.889GluGln: 2.889 ± 0.49
1.382GluArg: 1.382 ± 0.529
2.01GluSer: 2.01 ± 0.444
2.763GluThr: 2.763 ± 0.66
3.266GluVal: 3.266 ± 0.652
0.377GluTrp: 0.377 ± 0.246
3.768GluTyr: 3.768 ± 0.866
0.0GluXaa: 0.0 ± 0.0
Phe
3.266PheAla: 3.266 ± 0.628
1.13PheCys: 1.13 ± 0.508
3.14PheAsp: 3.14 ± 0.741
3.266PheGlu: 3.266 ± 0.516
2.261PhePhe: 2.261 ± 0.78
2.386PheGly: 2.386 ± 0.505
0.502PheHis: 0.502 ± 0.235
4.019PheIle: 4.019 ± 0.604
3.768PheLys: 3.768 ± 0.714
4.647PheLeu: 4.647 ± 0.703
0.754PheMet: 0.754 ± 0.289
3.391PheAsn: 3.391 ± 0.574
1.382PhePro: 1.382 ± 0.312
2.135PheGln: 2.135 ± 0.528
1.884PheArg: 1.884 ± 0.395
4.019PheSer: 4.019 ± 0.571
2.763PheThr: 2.763 ± 0.678
4.145PheVal: 4.145 ± 0.691
0.502PheTrp: 0.502 ± 0.314
1.884PheTyr: 1.884 ± 0.539
0.0PheXaa: 0.0 ± 0.0
Gly
2.889GlyAla: 2.889 ± 0.616
0.377GlyCys: 0.377 ± 0.215
1.633GlyAsp: 1.633 ± 0.434
3.014GlyGlu: 3.014 ± 0.537
3.14GlyPhe: 3.14 ± 0.509
2.763GlyGly: 2.763 ± 0.609
0.251GlyHis: 0.251 ± 0.193
4.647GlyIle: 4.647 ± 0.793
2.512GlyLys: 2.512 ± 0.53
4.521GlyLeu: 4.521 ± 0.64
1.382GlyMet: 1.382 ± 0.407
3.14GlyAsn: 3.14 ± 0.749
1.382GlyPro: 1.382 ± 0.447
1.382GlyGln: 1.382 ± 0.52
1.13GlyArg: 1.13 ± 0.381
3.517GlySer: 3.517 ± 0.75
1.633GlyThr: 1.633 ± 0.455
3.642GlyVal: 3.642 ± 0.603
0.251GlyTrp: 0.251 ± 0.177
3.14GlyTyr: 3.14 ± 0.704
0.0GlyXaa: 0.0 ± 0.0
His
1.13HisAla: 1.13 ± 0.3
0.0HisCys: 0.0 ± 0.0
0.754HisAsp: 0.754 ± 0.341
0.377HisGlu: 0.377 ± 0.204
1.13HisPhe: 1.13 ± 0.426
0.879HisGly: 0.879 ± 0.379
0.251HisHis: 0.251 ± 0.173
1.507HisIle: 1.507 ± 0.529
0.628HisLys: 0.628 ± 0.264
1.382HisLeu: 1.382 ± 0.404
0.126HisMet: 0.126 ± 0.121
0.377HisAsn: 0.377 ± 0.219
0.502HisPro: 0.502 ± 0.366
0.251HisGln: 0.251 ± 0.207
0.628HisArg: 0.628 ± 0.291
0.754HisSer: 0.754 ± 0.309
0.126HisThr: 0.126 ± 0.127
0.628HisVal: 0.628 ± 0.242
0.126HisTrp: 0.126 ± 0.115
0.502HisTyr: 0.502 ± 0.265
0.0HisXaa: 0.0 ± 0.0
Ile
6.405IleAla: 6.405 ± 0.775
0.879IleCys: 0.879 ± 0.335
4.27IleAsp: 4.27 ± 0.728
6.531IleGlu: 6.531 ± 1.061
6.029IlePhe: 6.029 ± 0.911
4.019IleGly: 4.019 ± 0.778
1.758IleHis: 1.758 ± 0.454
7.787IleIle: 7.787 ± 1.291
6.782IleLys: 6.782 ± 1.089
9.922IleLeu: 9.922 ± 1.504
1.507IleMet: 1.507 ± 0.533
5.024IleAsn: 5.024 ± 0.963
5.903IlePro: 5.903 ± 0.773
5.149IleGln: 5.149 ± 0.889
2.386IleArg: 2.386 ± 0.79
6.657IleSer: 6.657 ± 1.44
4.019IleThr: 4.019 ± 0.953
7.41IleVal: 7.41 ± 1.42
1.13IleTrp: 1.13 ± 0.285
4.019IleTyr: 4.019 ± 0.874
0.0IleXaa: 0.0 ± 0.0
Lys
4.396LysAla: 4.396 ± 0.691
0.251LysCys: 0.251 ± 0.27
3.14LysAsp: 3.14 ± 0.854
6.531LysGlu: 6.531 ± 1.16
3.517LysPhe: 3.517 ± 0.697
2.763LysGly: 2.763 ± 0.432
1.005LysHis: 1.005 ± 0.284
8.792LysIle: 8.792 ± 1.402
6.908LysLys: 6.908 ± 1.186
7.787LysLeu: 7.787 ± 1.002
2.638LysMet: 2.638 ± 0.644
4.396LysAsn: 4.396 ± 0.816
1.507LysPro: 1.507 ± 0.452
3.14LysGln: 3.14 ± 0.834
1.884LysArg: 1.884 ± 0.619
2.512LysSer: 2.512 ± 0.452
3.642LysThr: 3.642 ± 0.566
4.521LysVal: 4.521 ± 0.828
0.628LysTrp: 0.628 ± 0.252
5.903LysTyr: 5.903 ± 1.16
0.0LysXaa: 0.0 ± 0.0
Leu
5.652LeuAla: 5.652 ± 0.859
0.628LeuCys: 0.628 ± 0.293
5.275LeuAsp: 5.275 ± 0.983
6.28LeuGlu: 6.28 ± 0.836
3.893LeuPhe: 3.893 ± 0.722
4.145LeuGly: 4.145 ± 0.697
1.256LeuHis: 1.256 ± 0.394
7.913LeuIle: 7.913 ± 1.363
7.787LeuLys: 7.787 ± 1.025
9.043LeuLeu: 9.043 ± 1.982
2.386LeuMet: 2.386 ± 0.474
5.652LeuAsn: 5.652 ± 0.832
4.521LeuPro: 4.521 ± 0.705
5.903LeuGln: 5.903 ± 1.222
3.768LeuArg: 3.768 ± 0.93
6.657LeuSer: 6.657 ± 1.156
5.777LeuThr: 5.777 ± 1.05
3.391LeuVal: 3.391 ± 0.743
0.754LeuTrp: 0.754 ± 0.353
7.033LeuTyr: 7.033 ± 1.086
0.0LeuXaa: 0.0 ± 0.0
Met
1.758MetAla: 1.758 ± 0.587
0.0MetCys: 0.0 ± 0.0
0.377MetAsp: 0.377 ± 0.226
0.754MetGlu: 0.754 ± 0.318
1.005MetPhe: 1.005 ± 0.446
0.628MetGly: 0.628 ± 0.302
0.126MetHis: 0.126 ± 0.14
1.382MetIle: 1.382 ± 0.416
1.758MetLys: 1.758 ± 0.523
1.758MetLeu: 1.758 ± 0.515
0.754MetMet: 0.754 ± 0.249
0.754MetAsn: 0.754 ± 0.268
1.633MetPro: 1.633 ± 0.391
1.13MetGln: 1.13 ± 0.365
0.628MetArg: 0.628 ± 0.286
1.884MetSer: 1.884 ± 0.412
0.628MetThr: 0.628 ± 0.277
1.382MetVal: 1.382 ± 0.417
0.251MetTrp: 0.251 ± 0.17
1.256MetTyr: 1.256 ± 0.293
0.0MetXaa: 0.0 ± 0.0
Asn
5.024AsnAla: 5.024 ± 0.821
0.879AsnCys: 0.879 ± 0.275
2.638AsnAsp: 2.638 ± 0.626
2.638AsnGlu: 2.638 ± 0.486
5.149AsnPhe: 5.149 ± 0.894
1.884AsnGly: 1.884 ± 0.812
0.628AsnHis: 0.628 ± 0.252
7.41AsnIle: 7.41 ± 1.245
2.889AsnLys: 2.889 ± 0.856
6.154AsnLeu: 6.154 ± 0.917
0.879AsnMet: 0.879 ± 0.307
4.647AsnAsn: 4.647 ± 1.041
2.763AsnPro: 2.763 ± 0.589
2.512AsnGln: 2.512 ± 0.683
1.507AsnArg: 1.507 ± 0.374
5.024AsnSer: 5.024 ± 1.278
1.758AsnThr: 1.758 ± 0.502
4.773AsnVal: 4.773 ± 0.575
0.377AsnTrp: 0.377 ± 0.192
3.391AsnTyr: 3.391 ± 0.794
0.0AsnXaa: 0.0 ± 0.0
Pro
2.763ProAla: 2.763 ± 0.49
0.377ProCys: 0.377 ± 0.238
2.512ProAsp: 2.512 ± 0.637
2.386ProGlu: 2.386 ± 0.534
1.382ProPhe: 1.382 ± 0.445
2.01ProGly: 2.01 ± 0.47
0.628ProHis: 0.628 ± 0.264
3.266ProIle: 3.266 ± 0.478
2.135ProLys: 2.135 ± 0.571
2.386ProLeu: 2.386 ± 0.38
0.126ProMet: 0.126 ± 0.135
1.758ProAsn: 1.758 ± 0.384
1.884ProPro: 1.884 ± 0.363
1.507ProGln: 1.507 ± 0.405
1.758ProArg: 1.758 ± 0.491
2.889ProSer: 2.889 ± 0.718
2.889ProThr: 2.889 ± 0.676
2.638ProVal: 2.638 ± 0.671
0.251ProTrp: 0.251 ± 0.181
2.135ProTyr: 2.135 ± 0.482
0.0ProXaa: 0.0 ± 0.0
Gln
1.13GlnAla: 1.13 ± 0.298
0.126GlnCys: 0.126 ± 0.126
1.758GlnAsp: 1.758 ± 0.52
3.14GlnGlu: 3.14 ± 0.627
2.01GlnPhe: 2.01 ± 0.337
2.763GlnGly: 2.763 ± 0.473
0.754GlnHis: 0.754 ± 0.267
5.024GlnIle: 5.024 ± 0.676
4.396GlnLys: 4.396 ± 0.645
5.275GlnLeu: 5.275 ± 1.206
0.754GlnMet: 0.754 ± 0.25
4.019GlnAsn: 4.019 ± 0.97
1.005GlnPro: 1.005 ± 0.427
2.638GlnGln: 2.638 ± 0.575
0.754GlnArg: 0.754 ± 0.274
2.135GlnSer: 2.135 ± 0.374
2.386GlnThr: 2.386 ± 0.515
2.512GlnVal: 2.512 ± 0.574
0.251GlnTrp: 0.251 ± 0.187
3.642GlnTyr: 3.642 ± 0.722
0.0GlnXaa: 0.0 ± 0.0
Arg
1.507ArgAla: 1.507 ± 0.546
0.377ArgCys: 0.377 ± 0.2
1.005ArgAsp: 1.005 ± 0.341
2.01ArgGlu: 2.01 ± 0.606
1.884ArgPhe: 1.884 ± 0.574
1.13ArgGly: 1.13 ± 0.386
0.628ArgHis: 0.628 ± 0.26
3.642ArgIle: 3.642 ± 0.777
3.517ArgLys: 3.517 ± 0.797
2.512ArgLeu: 2.512 ± 0.477
0.628ArgMet: 0.628 ± 0.289
2.135ArgAsn: 2.135 ± 0.548
0.502ArgPro: 0.502 ± 0.229
1.633ArgGln: 1.633 ± 0.469
1.633ArgArg: 1.633 ± 0.555
2.386ArgSer: 2.386 ± 0.478
0.628ArgThr: 0.628 ± 0.253
2.261ArgVal: 2.261 ± 0.513
0.0ArgTrp: 0.0 ± 0.0
2.01ArgTyr: 2.01 ± 0.542
0.0ArgXaa: 0.0 ± 0.0
Ser
5.149SerAla: 5.149 ± 0.793
0.628SerCys: 0.628 ± 0.384
3.642SerAsp: 3.642 ± 0.906
3.014SerGlu: 3.014 ± 0.495
3.391SerPhe: 3.391 ± 0.703
4.019SerGly: 4.019 ± 1.136
0.628SerHis: 0.628 ± 0.248
5.149SerIle: 5.149 ± 1.078
3.893SerLys: 3.893 ± 0.706
5.401SerLeu: 5.401 ± 0.89
1.256SerMet: 1.256 ± 0.444
4.145SerAsn: 4.145 ± 0.786
2.135SerPro: 2.135 ± 0.673
3.14SerGln: 3.14 ± 0.704
1.758SerArg: 1.758 ± 0.439
2.638SerSer: 2.638 ± 0.792
2.889SerThr: 2.889 ± 0.668
2.889SerVal: 2.889 ± 0.75
0.879SerTrp: 0.879 ± 0.367
2.386SerTyr: 2.386 ± 0.634
0.0SerXaa: 0.0 ± 0.0
Thr
3.768ThrAla: 3.768 ± 0.903
0.126ThrCys: 0.126 ± 0.153
1.633ThrAsp: 1.633 ± 0.393
3.14ThrGlu: 3.14 ± 0.562
1.256ThrPhe: 1.256 ± 0.342
2.638ThrGly: 2.638 ± 0.579
0.502ThrHis: 0.502 ± 0.256
4.019ThrIle: 4.019 ± 0.711
2.01ThrLys: 2.01 ± 0.544
3.642ThrLeu: 3.642 ± 0.62
1.13ThrMet: 1.13 ± 0.41
4.27ThrAsn: 4.27 ± 0.931
3.391ThrPro: 3.391 ± 0.592
2.01ThrGln: 2.01 ± 0.432
1.507ThrArg: 1.507 ± 0.326
2.763ThrSer: 2.763 ± 0.654
3.893ThrThr: 3.893 ± 0.632
4.019ThrVal: 4.019 ± 0.625
0.377ThrTrp: 0.377 ± 0.206
2.386ThrTyr: 2.386 ± 0.506
0.0ThrXaa: 0.0 ± 0.0
Val
6.029ValAla: 6.029 ± 0.852
0.126ValCys: 0.126 ± 0.128
3.14ValAsp: 3.14 ± 0.554
4.773ValGlu: 4.773 ± 1.031
3.14ValPhe: 3.14 ± 0.642
3.391ValGly: 3.391 ± 0.646
0.754ValHis: 0.754 ± 0.36
4.773ValIle: 4.773 ± 0.724
3.642ValLys: 3.642 ± 0.9
6.405ValLeu: 6.405 ± 1.019
0.628ValMet: 0.628 ± 0.292
2.889ValAsn: 2.889 ± 0.513
2.512ValPro: 2.512 ± 0.68
2.512ValGln: 2.512 ± 0.634
2.135ValArg: 2.135 ± 0.569
4.898ValSer: 4.898 ± 0.898
3.14ValThr: 3.14 ± 0.636
2.638ValVal: 2.638 ± 0.524
0.251ValTrp: 0.251 ± 0.175
4.27ValTyr: 4.27 ± 1.1
0.0ValXaa: 0.0 ± 0.0
Trp
0.377TrpAla: 0.377 ± 0.224
0.126TrpCys: 0.126 ± 0.126
0.251TrpAsp: 0.251 ± 0.165
0.251TrpGlu: 0.251 ± 0.161
0.628TrpPhe: 0.628 ± 0.26
0.126TrpGly: 0.126 ± 0.151
0.126TrpHis: 0.126 ± 0.14
0.251TrpIle: 0.251 ± 0.175
1.13TrpLys: 1.13 ± 0.332
0.628TrpLeu: 0.628 ± 0.386
0.0TrpMet: 0.0 ± 0.0
1.382TrpAsn: 1.382 ± 0.41
0.0TrpPro: 0.0 ± 0.0
0.502TrpGln: 0.502 ± 0.189
0.754TrpArg: 0.754 ± 0.274
0.377TrpSer: 0.377 ± 0.419
0.502TrpThr: 0.502 ± 0.255
0.377TrpVal: 0.377 ± 0.204
0.0TrpTrp: 0.0 ± 0.0
0.879TrpTyr: 0.879 ± 0.298
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.391TyrAla: 3.391 ± 0.918
0.502TyrCys: 0.502 ± 0.241
3.266TyrAsp: 3.266 ± 0.709
2.512TyrGlu: 2.512 ± 0.577
4.019TyrPhe: 4.019 ± 0.833
3.642TyrGly: 3.642 ± 0.807
0.502TyrHis: 0.502 ± 0.207
4.773TyrIle: 4.773 ± 0.657
3.266TyrLys: 3.266 ± 0.79
6.908TyrLeu: 6.908 ± 0.605
1.13TyrMet: 1.13 ± 0.299
4.396TyrAsn: 4.396 ± 1.064
2.763TyrPro: 2.763 ± 0.773
2.889TyrGln: 2.889 ± 0.557
1.382TyrArg: 1.382 ± 0.498
2.763TyrSer: 2.763 ± 0.519
3.014TyrThr: 3.014 ± 0.682
4.145TyrVal: 4.145 ± 0.724
0.628TyrTrp: 0.628 ± 0.301
4.27TyrTyr: 4.27 ± 0.93
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 37 proteins (7963 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski