Amino acid dipepetide frequency for Kingella negevensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
11.92AlaAla: 11.92 ± 0.193
1.089AlaCys: 1.089 ± 0.045
5.324AlaAsp: 5.324 ± 0.099
6.665AlaGlu: 6.665 ± 0.15
3.761AlaPhe: 3.761 ± 0.083
6.109AlaGly: 6.109 ± 0.109
2.077AlaHis: 2.077 ± 0.063
5.439AlaIle: 5.439 ± 0.113
6.02AlaLys: 6.02 ± 0.111
9.915AlaLeu: 9.915 ± 0.132
2.89AlaMet: 2.89 ± 0.074
4.168AlaAsn: 4.168 ± 0.094
3.308AlaPro: 3.308 ± 0.092
5.677AlaGln: 5.677 ± 0.131
4.263AlaArg: 4.263 ± 0.092
4.618AlaSer: 4.618 ± 0.11
4.893AlaThr: 4.893 ± 0.089
6.721AlaVal: 6.721 ± 0.117
1.196AlaTrp: 1.196 ± 0.055
2.752AlaTyr: 2.752 ± 0.072
0.0AlaXaa: 0.0 ± 0.0
Cys
0.943CysAla: 0.943 ± 0.043
0.173CysCys: 0.173 ± 0.018
0.508CysAsp: 0.508 ± 0.03
0.618CysGlu: 0.618 ± 0.031
0.424CysPhe: 0.424 ± 0.026
1.06CysGly: 1.06 ± 0.053
0.265CysHis: 0.265 ± 0.024
0.489CysIle: 0.489 ± 0.029
0.39CysLys: 0.39 ± 0.024
0.968CysLeu: 0.968 ± 0.042
0.196CysMet: 0.196 ± 0.017
0.387CysAsn: 0.387 ± 0.027
0.504CysPro: 0.504 ± 0.031
0.462CysGln: 0.462 ± 0.029
0.472CysArg: 0.472 ± 0.031
0.697CysSer: 0.697 ± 0.032
0.526CysThr: 0.526 ± 0.031
0.757CysVal: 0.757 ± 0.037
0.106CysTrp: 0.106 ± 0.014
0.328CysTyr: 0.328 ± 0.025
0.0CysXaa: 0.0 ± 0.0
Asp
4.079AspAla: 4.079 ± 0.077
0.528AspCys: 0.528 ± 0.031
2.757AspAsp: 2.757 ± 0.083
3.843AspGlu: 3.843 ± 0.099
2.529AspPhe: 2.529 ± 0.066
3.62AspGly: 3.62 ± 0.088
0.745AspHis: 0.745 ± 0.041
3.166AspIle: 3.166 ± 0.093
3.344AspLys: 3.344 ± 0.075
5.315AspLeu: 5.315 ± 0.097
1.29AspMet: 1.29 ± 0.053
2.397AspAsn: 2.397 ± 0.061
1.645AspPro: 1.645 ± 0.057
1.209AspGln: 1.209 ± 0.044
1.72AspArg: 1.72 ± 0.047
2.617AspSer: 2.617 ± 0.065
2.797AspThr: 2.797 ± 0.075
3.799AspVal: 3.799 ± 0.076
0.895AspTrp: 0.895 ± 0.042
1.977AspTyr: 1.977 ± 0.059
0.0AspXaa: 0.0 ± 0.0
Glu
5.027GluAla: 5.027 ± 0.115
0.543GluCys: 0.543 ± 0.034
2.521GluAsp: 2.521 ± 0.074
3.344GluGlu: 3.344 ± 0.097
2.424GluPhe: 2.424 ± 0.055
2.612GluGly: 2.612 ± 0.079
1.613GluHis: 1.613 ± 0.052
4.118GluIle: 4.118 ± 0.096
4.102GluLys: 4.102 ± 0.095
6.227GluLeu: 6.227 ± 0.126
1.89GluMet: 1.89 ± 0.058
3.861GluAsn: 3.861 ± 0.089
2.044GluPro: 2.044 ± 0.063
3.886GluGln: 3.886 ± 0.075
3.474GluArg: 3.474 ± 0.075
2.801GluSer: 2.801 ± 0.079
4.009GluThr: 4.009 ± 0.088
3.555GluVal: 3.555 ± 0.087
0.94GluTrp: 0.94 ± 0.04
1.809GluTyr: 1.809 ± 0.059
0.0GluXaa: 0.0 ± 0.0
Phe
4.406PheAla: 4.406 ± 0.096
0.511PheCys: 0.511 ± 0.031
2.533PheAsp: 2.533 ± 0.06
2.275PheGlu: 2.275 ± 0.069
1.744PhePhe: 1.744 ± 0.063
3.329PheGly: 3.329 ± 0.088
0.884PheHis: 0.884 ± 0.039
2.362PheIle: 2.362 ± 0.06
1.943PheLys: 1.943 ± 0.064
3.581PheLeu: 3.581 ± 0.086
1.025PheMet: 1.025 ± 0.042
2.052PheAsn: 2.052 ± 0.062
1.598PhePro: 1.598 ± 0.061
1.764PheGln: 1.764 ± 0.062
1.761PheArg: 1.761 ± 0.064
3.005PheSer: 3.005 ± 0.067
2.256PheThr: 2.256 ± 0.058
2.975PheVal: 2.975 ± 0.074
0.605PheTrp: 0.605 ± 0.037
1.337PheTyr: 1.337 ± 0.055
0.0PheXaa: 0.0 ± 0.0
Gly
5.89GlyAla: 5.89 ± 0.104
0.943GlyCys: 0.943 ± 0.04
3.236GlyAsp: 3.236 ± 0.084
4.174GlyGlu: 4.174 ± 0.083
3.268GlyPhe: 3.268 ± 0.079
4.928GlyGly: 4.928 ± 0.128
1.332GlyHis: 1.332 ± 0.05
4.262GlyIle: 4.262 ± 0.105
5.072GlyLys: 5.072 ± 0.083
6.617GlyLeu: 6.617 ± 0.107
2.069GlyMet: 2.069 ± 0.056
2.95GlyAsn: 2.95 ± 0.115
0.784GlyPro: 0.784 ± 0.041
2.355GlyGln: 2.355 ± 0.061
2.893GlyArg: 2.893 ± 0.083
4.702GlySer: 4.702 ± 0.118
3.514GlyThr: 3.514 ± 0.095
5.242GlyVal: 5.242 ± 0.113
0.928GlyTrp: 0.928 ± 0.037
2.312GlyTyr: 2.312 ± 0.068
0.0GlyXaa: 0.0 ± 0.0
His
2.148HisAla: 2.148 ± 0.063
0.288HisCys: 0.288 ± 0.021
1.085HisAsp: 1.085 ± 0.042
1.394HisGlu: 1.394 ± 0.052
1.149HisPhe: 1.149 ± 0.046
1.682HisGly: 1.682 ± 0.054
0.658HisHis: 0.658 ± 0.036
1.737HisIle: 1.737 ± 0.055
1.142HisLys: 1.142 ± 0.049
2.039HisLeu: 2.039 ± 0.065
0.451HisMet: 0.451 ± 0.025
1.072HisAsn: 1.072 ± 0.049
1.032HisPro: 1.032 ± 0.044
0.992HisGln: 0.992 ± 0.045
1.027HisArg: 1.027 ± 0.045
1.298HisSer: 1.298 ± 0.053
1.318HisThr: 1.318 ± 0.05
1.27HisVal: 1.27 ± 0.044
0.312HisTrp: 0.312 ± 0.026
0.819HisTyr: 0.819 ± 0.035
0.0HisXaa: 0.0 ± 0.0
Ile
6.791IleAla: 6.791 ± 0.111
0.67IleCys: 0.67 ± 0.033
3.33IleAsp: 3.33 ± 0.076
3.602IleGlu: 3.602 ± 0.079
2.295IlePhe: 2.295 ± 0.069
4.587IleGly: 4.587 ± 0.108
1.298IleHis: 1.298 ± 0.054
3.488IleIle: 3.488 ± 0.088
2.876IleLys: 2.876 ± 0.072
5.216IleLeu: 5.216 ± 0.095
1.404IleMet: 1.404 ± 0.055
2.715IleAsn: 2.715 ± 0.079
2.379IlePro: 2.379 ± 0.071
2.419IleGln: 2.419 ± 0.066
2.777IleArg: 2.777 ± 0.071
3.637IleSer: 3.637 ± 0.089
3.583IleThr: 3.583 ± 0.076
4.208IleVal: 4.208 ± 0.1
0.645IleTrp: 0.645 ± 0.04
1.596IleTyr: 1.596 ± 0.059
0.0IleXaa: 0.0 ± 0.0
Lys
5.046LysAla: 5.046 ± 0.113
0.338LysCys: 0.338 ± 0.025
2.679LysAsp: 2.679 ± 0.074
3.094LysGlu: 3.094 ± 0.082
1.878LysPhe: 1.878 ± 0.06
3.297LysGly: 3.297 ± 0.075
1.397LysHis: 1.397 ± 0.048
3.824LysIle: 3.824 ± 0.083
3.342LysLys: 3.342 ± 0.093
5.659LysLeu: 5.659 ± 0.1
1.916LysMet: 1.916 ± 0.055
2.987LysAsn: 2.987 ± 0.084
2.637LysPro: 2.637 ± 0.068
3.335LysGln: 3.335 ± 0.077
2.885LysArg: 2.885 ± 0.086
2.91LysSer: 2.91 ± 0.068
3.87LysThr: 3.87 ± 0.072
3.406LysVal: 3.406 ± 0.079
0.74LysTrp: 0.74 ± 0.039
1.449LysTyr: 1.449 ± 0.049
0.0LysXaa: 0.0 ± 0.0
Leu
10.428LeuAla: 10.428 ± 0.166
0.987LeuCys: 0.987 ± 0.044
5.186LeuAsp: 5.186 ± 0.108
4.781LeuGlu: 4.781 ± 0.106
4.081LeuPhe: 4.081 ± 0.09
6.778LeuGly: 6.778 ± 0.109
2.27LeuHis: 2.27 ± 0.067
5.392LeuIle: 5.392 ± 0.107
5.737LeuLys: 5.737 ± 0.097
9.545LeuLeu: 9.545 ± 0.203
2.444LeuMet: 2.444 ± 0.071
4.975LeuAsn: 4.975 ± 0.107
5.59LeuPro: 5.59 ± 0.105
4.645LeuGln: 4.645 ± 0.098
4.88LeuArg: 4.88 ± 0.093
6.714LeuSer: 6.714 ± 0.124
5.367LeuThr: 5.367 ± 0.101
6.193LeuVal: 6.193 ± 0.127
1.013LeuTrp: 1.013 ± 0.045
2.399LeuTyr: 2.399 ± 0.069
0.0LeuXaa: 0.0 ± 0.0
Met
2.467MetAla: 2.467 ± 0.076
0.219MetCys: 0.219 ± 0.021
1.097MetAsp: 1.097 ± 0.044
1.149MetGlu: 1.149 ± 0.048
0.953MetPhe: 0.953 ± 0.04
1.807MetGly: 1.807 ± 0.061
0.469MetHis: 0.469 ± 0.024
1.533MetIle: 1.533 ± 0.056
1.761MetLys: 1.761 ± 0.056
2.779MetLeu: 2.779 ± 0.075
0.809MetMet: 0.809 ± 0.037
1.36MetAsn: 1.36 ± 0.05
1.275MetPro: 1.275 ± 0.044
1.337MetGln: 1.337 ± 0.045
1.347MetArg: 1.347 ± 0.047
1.596MetSer: 1.596 ± 0.058
1.462MetThr: 1.462 ± 0.056
1.591MetVal: 1.591 ± 0.048
0.253MetTrp: 0.253 ± 0.022
0.605MetTyr: 0.605 ± 0.032
0.0MetXaa: 0.0 ± 0.0
Asn
4.518AsnAla: 4.518 ± 0.097
0.432AsnCys: 0.432 ± 0.027
2.198AsnAsp: 2.198 ± 0.068
2.555AsnGlu: 2.555 ± 0.062
1.601AsnPhe: 1.601 ± 0.052
3.821AsnGly: 3.821 ± 0.124
1.203AsnHis: 1.203 ± 0.05
3.062AsnIle: 3.062 ± 0.078
2.473AsnLys: 2.473 ± 0.062
4.054AsnLeu: 4.054 ± 0.079
1.092AsnMet: 1.092 ± 0.044
2.271AsnAsn: 2.271 ± 0.113
2.511AsnPro: 2.511 ± 0.058
2.429AsnGln: 2.429 ± 0.073
2.315AsnArg: 2.315 ± 0.065
2.359AsnSer: 2.359 ± 0.089
2.602AsnThr: 2.602 ± 0.088
3.243AsnVal: 3.243 ± 0.101
0.694AsnTrp: 0.694 ± 0.033
1.407AsnTyr: 1.407 ± 0.053
0.0AsnXaa: 0.0 ± 0.0
Pro
3.451ProAla: 3.451 ± 0.095
0.352ProCys: 0.352 ± 0.027
2.278ProAsp: 2.278 ± 0.07
4.647ProGlu: 4.647 ± 0.094
1.898ProPhe: 1.898 ± 0.069
1.025ProGly: 1.025 ± 0.047
1.01ProHis: 1.01 ± 0.046
2.399ProIle: 2.399 ± 0.064
2.432ProLys: 2.432 ± 0.068
3.607ProLeu: 3.607 ± 0.092
0.993ProMet: 0.993 ± 0.043
2.22ProAsn: 2.22 ± 0.062
1.29ProPro: 1.29 ± 0.066
1.908ProGln: 1.908 ± 0.06
1.546ProArg: 1.546 ± 0.052
1.968ProSer: 1.968 ± 0.059
2.536ProThr: 2.536 ± 0.067
3.059ProVal: 3.059 ± 0.079
0.337ProTrp: 0.337 ± 0.024
1.243ProTyr: 1.243 ± 0.046
0.0ProXaa: 0.0 ± 0.0
Gln
5.721GlnAla: 5.721 ± 0.122
0.365GlnCys: 0.365 ± 0.024
2.084GlnAsp: 2.084 ± 0.066
2.424GlnGlu: 2.424 ± 0.069
2.029GlnPhe: 2.029 ± 0.063
2.787GlnGly: 2.787 ± 0.07
1.347GlnHis: 1.347 ± 0.062
3.22GlnIle: 3.22 ± 0.076
2.68GlnLys: 2.68 ± 0.078
4.277GlnLeu: 4.277 ± 0.092
1.271GlnMet: 1.271 ± 0.043
2.715GlnAsn: 2.715 ± 0.077
2.55GlnPro: 2.55 ± 0.079
2.913GlnGln: 2.913 ± 0.098
2.424GlnArg: 2.424 ± 0.068
2.717GlnSer: 2.717 ± 0.081
3.2GlnThr: 3.2 ± 0.09
2.632GlnVal: 2.632 ± 0.062
0.615GlnTrp: 0.615 ± 0.035
1.528GlnTyr: 1.528 ± 0.055
0.0GlnXaa: 0.0 ± 0.0
Arg
4.047ArgAla: 4.047 ± 0.087
0.399ArgCys: 0.399 ± 0.029
2.501ArgAsp: 2.501 ± 0.063
3.545ArgGlu: 3.545 ± 0.081
2.256ArgPhe: 2.256 ± 0.068
2.962ArgGly: 2.962 ± 0.076
1.114ArgHis: 1.114 ± 0.053
2.759ArgIle: 2.759 ± 0.079
2.56ArgLys: 2.56 ± 0.077
5.099ArgLeu: 5.099 ± 0.116
1.278ArgMet: 1.278 ± 0.049
1.918ArgAsn: 1.918 ± 0.061
1.667ArgPro: 1.667 ± 0.059
2.479ArgGln: 2.479 ± 0.07
2.375ArgArg: 2.375 ± 0.063
2.424ArgSer: 2.424 ± 0.064
2.171ArgThr: 2.171 ± 0.067
3.432ArgVal: 3.432 ± 0.093
0.536ArgTrp: 0.536 ± 0.028
1.843ArgTyr: 1.843 ± 0.06
0.0ArgXaa: 0.0 ± 0.0
Ser
5.365SerAla: 5.365 ± 0.102
0.581SerCys: 0.581 ± 0.034
2.87SerAsp: 2.87 ± 0.065
3.426SerGlu: 3.426 ± 0.076
2.374SerPhe: 2.374 ± 0.061
5.419SerGly: 5.419 ± 0.117
1.342SerHis: 1.342 ± 0.051
2.972SerIle: 2.972 ± 0.072
2.888SerLys: 2.888 ± 0.072
6.121SerLeu: 6.121 ± 0.126
1.266SerMet: 1.266 ± 0.047
2.352SerAsn: 2.352 ± 0.089
2.203SerPro: 2.203 ± 0.058
2.662SerGln: 2.662 ± 0.074
2.699SerArg: 2.699 ± 0.08
3.307SerSer: 3.307 ± 0.093
2.769SerThr: 2.769 ± 0.095
3.942SerVal: 3.942 ± 0.083
0.68SerTrp: 0.68 ± 0.032
1.578SerTyr: 1.578 ± 0.056
0.0SerXaa: 0.0 ± 0.0
Thr
5.652ThrAla: 5.652 ± 0.108
0.503ThrCys: 0.503 ± 0.025
2.712ThrAsp: 2.712 ± 0.07
3.312ThrGlu: 3.312 ± 0.079
2.176ThrPhe: 2.176 ± 0.058
4.042ThrGly: 4.042 ± 0.11
1.348ThrHis: 1.348 ± 0.05
3.159ThrIle: 3.159 ± 0.076
2.439ThrLys: 2.439 ± 0.054
6.034ThrLeu: 6.034 ± 0.103
1.101ThrMet: 1.101 ± 0.046
1.975ThrAsn: 1.975 ± 0.089
3.05ThrPro: 3.05 ± 0.073
3.01ThrGln: 3.01 ± 0.08
2.568ThrArg: 2.568 ± 0.063
2.7ThrSer: 2.7 ± 0.07
2.9ThrThr: 2.9 ± 0.079
4.288ThrVal: 4.288 ± 0.1
0.632ThrTrp: 0.632 ± 0.033
1.548ThrTyr: 1.548 ± 0.054
0.0ThrXaa: 0.0 ± 0.0
Val
6.987ValAla: 6.987 ± 0.121
0.828ValCys: 0.828 ± 0.039
3.191ValAsp: 3.191 ± 0.074
3.86ValGlu: 3.86 ± 0.091
2.923ValPhe: 2.923 ± 0.08
4.7ValGly: 4.7 ± 0.103
1.394ValHis: 1.394 ± 0.044
3.983ValIle: 3.983 ± 0.084
3.657ValLys: 3.657 ± 0.1
7.409ValLeu: 7.409 ± 0.151
1.72ValMet: 1.72 ± 0.056
2.813ValAsn: 2.813 ± 0.078
2.71ValPro: 2.71 ± 0.072
3.087ValGln: 3.087 ± 0.073
3.262ValArg: 3.262 ± 0.08
4.602ValSer: 4.602 ± 0.093
3.027ValThr: 3.027 ± 0.083
4.736ValVal: 4.736 ± 0.102
0.89ValTrp: 0.89 ± 0.043
1.916ValTyr: 1.916 ± 0.056
0.0ValXaa: 0.0 ± 0.0
Trp
1.101TrpAla: 1.101 ± 0.051
0.173TrpCys: 0.173 ± 0.017
0.593TrpAsp: 0.593 ± 0.033
0.566TrpGlu: 0.566 ± 0.034
0.695TrpPhe: 0.695 ± 0.035
0.784TrpGly: 0.784 ± 0.037
0.387TrpHis: 0.387 ± 0.025
0.678TrpIle: 0.678 ± 0.034
0.558TrpLys: 0.558 ± 0.034
1.829TrpLeu: 1.829 ± 0.057
0.198TrpMet: 0.198 ± 0.02
0.466TrpAsn: 0.466 ± 0.027
0.089TrpPro: 0.089 ± 0.014
1.253TrpGln: 1.253 ± 0.054
0.846TrpArg: 0.846 ± 0.044
0.466TrpSer: 0.466 ± 0.03
0.591TrpThr: 0.591 ± 0.035
0.854TrpVal: 0.854 ± 0.039
0.196TrpTrp: 0.196 ± 0.02
0.389TrpTyr: 0.389 ± 0.032
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.821TyrAla: 2.821 ± 0.07
0.353TyrCys: 0.353 ± 0.025
1.59TyrAsp: 1.59 ± 0.058
1.526TyrGlu: 1.526 ± 0.045
1.488TyrPhe: 1.488 ± 0.053
2.122TyrGly: 2.122 ± 0.069
0.759TyrHis: 0.759 ± 0.034
1.474TyrIle: 1.474 ± 0.05
1.27TyrLys: 1.27 ± 0.05
3.114TyrLeu: 3.114 ± 0.077
0.566TyrMet: 0.566 ± 0.03
1.184TyrAsn: 1.184 ± 0.046
1.333TyrPro: 1.333 ± 0.047
1.673TyrGln: 1.673 ± 0.056
1.831TyrArg: 1.831 ± 0.058
1.678TyrSer: 1.678 ± 0.06
1.757TyrThr: 1.757 ± 0.056
1.792TyrVal: 1.792 ± 0.056
0.501TyrTrp: 0.501 ± 0.029
0.938TyrTyr: 0.938 ± 0.05
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2100 proteins (596964 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski