Amino acid dipepetide frequency for Marinicauda pacifica

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	17.154AlaAla: 17.154 ± 0.216	1.183AlaCys: 1.183 ± 0.039	7.261AlaAsp: 7.261 ± 0.098	8.523AlaGlu: 8.523 ± 0.107	4.854AlaPhe: 4.854 ± 0.07	12.51AlaGly: 12.51 ± 0.144	2.28AlaHis: 2.28 ± 0.054	6.055AlaIle: 6.055 ± 0.095	3.122AlaLys: 3.122 ± 0.086	14.608AlaLeu: 14.608 ± 0.186	3.32AlaMet: 3.32 ± 0.075	2.769AlaAsn: 2.769 ± 0.061	6.129AlaPro: 6.129 ± 0.092	4.222AlaGln: 4.222 ± 0.072	10.993AlaArg: 10.993 ± 0.131	6.986AlaSer: 6.986 ± 0.111	5.003AlaThr: 5.003 ± 0.07	8.511AlaVal: 8.511 ± 0.11	1.653AlaTrp: 1.653 ± 0.047	2.704AlaTyr: 2.704 ± 0.064	0.0AlaXaa: 0.0 ± 0.0
Cys	1.071CysAla: 1.071 ± 0.035	0.082CysCys: 0.082 ± 0.009	0.519CysAsp: 0.519 ± 0.025	0.496CysGlu: 0.496 ± 0.023	0.261CysPhe: 0.261 ± 0.018	0.828CysGly: 0.828 ± 0.035	0.167CysHis: 0.167 ± 0.013	0.263CysIle: 0.263 ± 0.017	0.165CysLys: 0.165 ± 0.012	0.706CysLeu: 0.706 ± 0.032	0.124CysMet: 0.124 ± 0.01	0.171CysAsn: 0.171 ± 0.014	0.461CysPro: 0.461 ± 0.024	0.191CysGln: 0.191 ± 0.015	0.498CysArg: 0.498 ± 0.022	0.402CysSer: 0.402 ± 0.02	0.366CysThr: 0.366 ± 0.023	0.602CysVal: 0.602 ± 0.027	0.092CysTrp: 0.092 ± 0.009	0.144CysTyr: 0.144 ± 0.013	0.0CysXaa: 0.0 ± 0.0
Asp	8.171AspAla: 8.171 ± 0.107	0.431AspCys: 0.431 ± 0.026	3.471AspAsp: 3.471 ± 0.071	4.394AspGlu: 4.394 ± 0.082	2.287AspPhe: 2.287 ± 0.049	5.659AspGly: 5.659 ± 0.097	1.291AspHis: 1.291 ± 0.037	2.865AspIle: 2.865 ± 0.06	1.444AspLys: 1.444 ± 0.047	6.2AspLeu: 6.2 ± 0.098	1.442AspMet: 1.442 ± 0.044	1.224AspAsn: 1.224 ± 0.035	3.895AspPro: 3.895 ± 0.063	1.854AspGln: 1.854 ± 0.039	4.846AspArg: 4.846 ± 0.081	2.652AspSer: 2.652 ± 0.054	3.156AspThr: 3.156 ± 0.07	4.188AspVal: 4.188 ± 0.072	1.116AspTrp: 1.116 ± 0.034	1.634AspTyr: 1.634 ± 0.044	0.0AspXaa: 0.0 ± 0.0
Glu	9.966GluAla: 9.966 ± 0.128	0.34GluCys: 0.34 ± 0.022	4.266GluAsp: 4.266 ± 0.07	4.232GluGlu: 4.232 ± 0.078	2.042GluPhe: 2.042 ± 0.044	5.291GluGly: 5.291 ± 0.077	1.281GluHis: 1.281 ± 0.035	3.8GluIle: 3.8 ± 0.065	1.874GluLys: 1.874 ± 0.06	5.815GluLeu: 5.815 ± 0.085	1.587GluMet: 1.587 ± 0.047	1.694GluAsn: 1.694 ± 0.041	3.349GluPro: 3.349 ± 0.072	2.114GluGln: 2.114 ± 0.049	5.908GluArg: 5.908 ± 0.082	3.198GluSer: 3.198 ± 0.065	4.658GluThr: 4.658 ± 0.073	4.137GluVal: 4.137 ± 0.069	0.713GluTrp: 0.713 ± 0.031	1.205GluTyr: 1.205 ± 0.038	0.0GluXaa: 0.0 ± 0.0
Phe	5.024PheAla: 5.024 ± 0.083	0.326PheCys: 0.326 ± 0.02	3.037PheAsp: 3.037 ± 0.062	2.905PheGlu: 2.905 ± 0.063	1.487PhePhe: 1.487 ± 0.051	3.494PheGly: 3.494 ± 0.065	0.704PheHis: 0.704 ± 0.029	1.657PheIle: 1.657 ± 0.049	0.951PheLys: 0.951 ± 0.036	3.27PheLeu: 3.27 ± 0.072	0.831PheMet: 0.831 ± 0.035	1.067PheAsn: 1.067 ± 0.037	1.392PhePro: 1.392 ± 0.043	0.962PheGln: 0.962 ± 0.033	1.885PheArg: 1.885 ± 0.05	2.301PheSer: 2.301 ± 0.054	2.031PheThr: 2.031 ± 0.049	2.636PheVal: 2.636 ± 0.053	0.52PheTrp: 0.52 ± 0.029	0.87PheTyr: 0.87 ± 0.035	0.0PheXaa: 0.0 ± 0.0
Gly	10.549GlyAla: 10.549 ± 0.112	0.714GlyCys: 0.714 ± 0.028	5.078GlyAsp: 5.078 ± 0.091	6.692GlyGlu: 6.692 ± 0.098	3.75GlyPhe: 3.75 ± 0.065	7.652GlyGly: 7.652 ± 0.124	1.773GlyHis: 1.773 ± 0.05	3.547GlyIle: 3.547 ± 0.067	2.468GlyLys: 2.468 ± 0.067	9.408GlyLeu: 9.408 ± 0.114	2.044GlyMet: 2.044 ± 0.05	1.715GlyAsn: 1.715 ± 0.052	4.131GlyPro: 4.131 ± 0.076	3.122GlyGln: 3.122 ± 0.064	6.422GlyArg: 6.422 ± 0.088	4.585GlySer: 4.585 ± 0.081	3.977GlyThr: 3.977 ± 0.071	6.582GlyVal: 6.582 ± 0.076	1.461GlyTrp: 1.461 ± 0.041	2.296GlyTyr: 2.296 ± 0.05	0.0GlyXaa: 0.0 ± 0.0
His	2.452HisAla: 2.452 ± 0.057	0.188HisCys: 0.188 ± 0.017	1.122HisAsp: 1.122 ± 0.036	1.196HisGlu: 1.196 ± 0.036	0.787HisPhe: 0.787 ± 0.034	1.79HisGly: 1.79 ± 0.04	0.489HisHis: 0.489 ± 0.025	0.844HisIle: 0.844 ± 0.032	0.454HisLys: 0.454 ± 0.023	1.81HisLeu: 1.81 ± 0.052	0.439HisMet: 0.439 ± 0.024	0.444HisAsn: 0.444 ± 0.021	1.227HisPro: 1.227 ± 0.035	0.541HisGln: 0.541 ± 0.025	1.275HisArg: 1.275 ± 0.038	0.888HisSer: 0.888 ± 0.036	0.88HisThr: 0.88 ± 0.038	1.375HisVal: 1.375 ± 0.04	0.26HisTrp: 0.26 ± 0.013	0.48HisTyr: 0.48 ± 0.023	0.0HisXaa: 0.0 ± 0.0
Ile	6.958IleAla: 6.958 ± 0.1	0.456IleCys: 0.456 ± 0.023	3.48IleAsp: 3.48 ± 0.056	4.17IleGlu: 4.17 ± 0.069	1.545IlePhe: 1.545 ± 0.044	4.397IleGly: 4.397 ± 0.078	0.846IleHis: 0.846 ± 0.036	1.801IleIle: 1.801 ± 0.055	1.179IleLys: 1.179 ± 0.037	4.371IleLeu: 4.371 ± 0.071	0.843IleMet: 0.843 ± 0.033	1.177IleAsn: 1.177 ± 0.041	1.913IlePro: 1.913 ± 0.049	1.227IleGln: 1.227 ± 0.038	2.837IleArg: 2.837 ± 0.057	2.701IleSer: 2.701 ± 0.06	2.296IleThr: 2.296 ± 0.053	3.855IleVal: 3.855 ± 0.064	0.574IleTrp: 0.574 ± 0.028	1.047IleTyr: 1.047 ± 0.031	0.0IleXaa: 0.0 ± 0.0
Lys	3.708LysAla: 3.708 ± 0.075	0.114LysCys: 0.114 ± 0.011	1.508LysAsp: 1.508 ± 0.053	1.301LysGlu: 1.301 ± 0.047	0.724LysPhe: 0.724 ± 0.028	2.081LysGly: 2.081 ± 0.061	0.5LysHis: 0.5 ± 0.024	1.285LysIle: 1.285 ± 0.039	1.161LysLys: 1.161 ± 0.048	2.415LysLeu: 2.415 ± 0.054	0.614LysMet: 0.614 ± 0.025	0.639LysAsn: 0.639 ± 0.028	1.689LysPro: 1.689 ± 0.056	0.762LysGln: 0.762 ± 0.029	2.159LysArg: 2.159 ± 0.062	1.728LysSer: 1.728 ± 0.05	1.78LysThr: 1.78 ± 0.049	1.704LysVal: 1.704 ± 0.054	0.277LysTrp: 0.277 ± 0.018	0.472LysTyr: 0.472 ± 0.025	0.0LysXaa: 0.0 ± 0.0
Leu	13.457LeuAla: 13.457 ± 0.171	0.779LeuCys: 0.779 ± 0.033	6.844LeuAsp: 6.844 ± 0.093	6.354LeuGlu: 6.354 ± 0.098	3.732LeuPhe: 3.732 ± 0.068	8.058LeuGly: 8.058 ± 0.105	1.759LeuHis: 1.759 ± 0.049	5.261LeuIle: 5.261 ± 0.084	3.19LeuLys: 3.19 ± 0.082	8.473LeuLeu: 8.473 ± 0.131	2.301LeuMet: 2.301 ± 0.051	2.544LeuAsn: 2.544 ± 0.055	4.748LeuPro: 4.748 ± 0.071	2.609LeuGln: 2.609 ± 0.055	6.554LeuArg: 6.554 ± 0.101	6.735LeuSer: 6.735 ± 0.086	5.626LeuThr: 5.626 ± 0.091	7.305LeuVal: 7.305 ± 0.113	1.055LeuTrp: 1.055 ± 0.035	2.09LeuTyr: 2.09 ± 0.051	0.0LeuXaa: 0.0 ± 0.0
Met	2.998MetAla: 2.998 ± 0.06	0.135MetCys: 0.135 ± 0.013	1.275MetAsp: 1.275 ± 0.041	1.225MetGlu: 1.225 ± 0.035	0.635MetPhe: 0.635 ± 0.027	1.756MetGly: 1.756 ± 0.044	0.364MetHis: 0.364 ± 0.02	1.238MetIle: 1.238 ± 0.036	0.927MetLys: 0.927 ± 0.03	2.063MetLeu: 2.063 ± 0.049	0.635MetMet: 0.635 ± 0.026	0.688MetAsn: 0.688 ± 0.031	1.194MetPro: 1.194 ± 0.034	0.665MetGln: 0.665 ± 0.029	1.802MetArg: 1.802 ± 0.047	1.691MetSer: 1.691 ± 0.039	1.84MetThr: 1.84 ± 0.044	1.429MetVal: 1.429 ± 0.034	0.204MetTrp: 0.204 ± 0.016	0.275MetTyr: 0.275 ± 0.019	0.0MetXaa: 0.0 ± 0.0
Asn	3.172AsnAla: 3.172 ± 0.055	0.179AsnCys: 0.179 ± 0.015	1.285AsnAsp: 1.285 ± 0.039	1.36AsnGlu: 1.36 ± 0.036	0.897AsnPhe: 0.897 ± 0.035	2.074AsnGly: 2.074 ± 0.056	0.409AsnHis: 0.409 ± 0.021	1.093AsnIle: 1.093 ± 0.037	0.544AsnLys: 0.544 ± 0.024	2.398AsnLeu: 2.398 ± 0.066	0.543AsnMet: 0.543 ± 0.025	0.537AsnAsn: 0.537 ± 0.026	1.643AsnPro: 1.643 ± 0.044	0.703AsnGln: 0.703 ± 0.031	1.66AsnArg: 1.66 ± 0.05	1.122AsnSer: 1.122 ± 0.043	1.19AsnThr: 1.19 ± 0.044	1.68AsnVal: 1.68 ± 0.048	0.363AsnTrp: 0.363 ± 0.021	0.623AsnTyr: 0.623 ± 0.024	0.0AsnXaa: 0.0 ± 0.0
Pro	6.408ProAla: 6.408 ± 0.085	0.297ProCys: 0.297 ± 0.019	4.235ProAsp: 4.235 ± 0.08	3.951ProGlu: 3.951 ± 0.064	1.893ProPhe: 1.893 ± 0.048	5.256ProGly: 5.256 ± 0.078	0.945ProHis: 0.945 ± 0.037	2.006ProIle: 2.006 ± 0.047	1.222ProLys: 1.222 ± 0.043	4.278ProLeu: 4.278 ± 0.062	1.009ProMet: 1.009 ± 0.032	1.122ProAsn: 1.122 ± 0.036	2.249ProPro: 2.249 ± 0.069	1.516ProGln: 1.516 ± 0.045	3.118ProArg: 3.118 ± 0.062	2.449ProSer: 2.449 ± 0.055	1.841ProThr: 1.841 ± 0.048	4.481ProVal: 4.481 ± 0.07	0.606ProTrp: 0.606 ± 0.029	1.042ProTyr: 1.042 ± 0.034	0.0ProXaa: 0.0 ± 0.0
Gln	4.399GlnAla: 4.399 ± 0.077	0.169GlnCys: 0.169 ± 0.013	1.717GlnAsp: 1.717 ± 0.042	1.593GlnGlu: 1.593 ± 0.045	0.978GlnPhe: 0.978 ± 0.038	2.47GlnGly: 2.47 ± 0.047	0.481GlnHis: 0.481 ± 0.023	1.829GlnIle: 1.829 ± 0.05	0.74GlnLys: 0.74 ± 0.03	2.743GlnLeu: 2.743 ± 0.05	0.73GlnMet: 0.73 ± 0.026	0.758GlnAsn: 0.758 ± 0.034	1.519GlnPro: 1.519 ± 0.039	0.883GlnGln: 0.883 ± 0.035	2.324GlnArg: 2.324 ± 0.054	1.997GlnSer: 1.997 ± 0.046	1.99GlnThr: 1.99 ± 0.054	2.146GlnVal: 2.146 ± 0.053	0.325GlnTrp: 0.325 ± 0.02	0.532GlnTyr: 0.532 ± 0.024	0.0GlnXaa: 0.0 ± 0.0
Arg	9.25ArgAla: 9.25 ± 0.111	0.484ArgCys: 0.484 ± 0.025	4.336ArgAsp: 4.336 ± 0.07	5.313ArgGlu: 5.313 ± 0.08	3.326ArgPhe: 3.326 ± 0.064	5.033ArgGly: 5.033 ± 0.081	1.536ArgHis: 1.536 ± 0.044	3.843ArgIle: 3.843 ± 0.058	1.984ArgLys: 1.984 ± 0.054	8.682ArgLeu: 8.682 ± 0.112	1.756ArgMet: 1.756 ± 0.045	1.658ArgAsn: 1.658 ± 0.048	3.656ArgPro: 3.656 ± 0.073	2.385ArgGln: 2.385 ± 0.044	5.831ArgArg: 5.831 ± 0.095	3.769ArgSer: 3.769 ± 0.063	3.667ArgThr: 3.667 ± 0.059	5.159ArgVal: 5.159 ± 0.074	1.075ArgTrp: 1.075 ± 0.036	1.848ArgTyr: 1.848 ± 0.05	0.0ArgXaa: 0.0 ± 0.0
Ser	7.004SerAla: 7.004 ± 0.095	0.374SerCys: 0.374 ± 0.021	3.369SerAsp: 3.369 ± 0.071	3.586SerGlu: 3.586 ± 0.056	2.063SerPhe: 2.063 ± 0.045	5.978SerGly: 5.978 ± 0.076	0.999SerHis: 0.999 ± 0.035	2.532SerIle: 2.532 ± 0.053	1.33SerLys: 1.33 ± 0.052	5.476SerLeu: 5.476 ± 0.082	1.315SerMet: 1.315 ± 0.036	1.32SerAsn: 1.32 ± 0.041	2.74SerPro: 2.74 ± 0.064	1.81SerGln: 1.81 ± 0.05	4.114SerArg: 4.114 ± 0.072	2.954SerSer: 2.954 ± 0.072	2.471SerThr: 2.471 ± 0.052	4.14SerVal: 4.14 ± 0.078	0.831SerTrp: 0.831 ± 0.033	1.19SerTyr: 1.19 ± 0.041	0.0SerXaa: 0.0 ± 0.0
Thr	6.286ThrAla: 6.286 ± 0.094	0.374ThrCys: 0.374 ± 0.02	2.786ThrAsp: 2.786 ± 0.054	2.875ThrGlu: 2.875 ± 0.062	1.661ThrPhe: 1.661 ± 0.045	5.696ThrGly: 5.696 ± 0.082	1.021ThrHis: 1.021 ± 0.029	2.384ThrIle: 2.384 ± 0.06	1.073ThrLys: 1.073 ± 0.036	6.047ThrLeu: 6.047 ± 0.091	0.939ThrMet: 0.939 ± 0.029	1.127ThrAsn: 1.127 ± 0.036	3.286ThrPro: 3.286 ± 0.058	1.55ThrGln: 1.55 ± 0.041	3.698ThrArg: 3.698 ± 0.069	2.601ThrSer: 2.601 ± 0.061	2.333ThrThr: 2.333 ± 0.061	3.944ThrVal: 3.944 ± 0.077	0.554ThrTrp: 0.554 ± 0.026	1.186ThrTyr: 1.186 ± 0.043	0.0ThrXaa: 0.0 ± 0.0
Val	7.824ValAla: 7.824 ± 0.108	0.656ValCys: 0.656 ± 0.029	4.37ValAsp: 4.37 ± 0.079	5.153ValGlu: 5.153 ± 0.075	3.071ValPhe: 3.071 ± 0.061	5.025ValGly: 5.025 ± 0.087	1.375ValHis: 1.375 ± 0.048	3.801ValIle: 3.801 ± 0.073	1.918ValLys: 1.918 ± 0.058	7.064ValLeu: 7.064 ± 0.097	1.813ValMet: 1.813 ± 0.048	1.939ValAsn: 1.939 ± 0.051	3.064ValPro: 3.064 ± 0.059	1.966ValGln: 1.966 ± 0.052	5.527ValArg: 5.527 ± 0.076	4.686ValSer: 4.686 ± 0.074	4.338ValThr: 4.338 ± 0.065	4.919ValVal: 4.919 ± 0.085	1.021ValTrp: 1.021 ± 0.038	1.593ValTyr: 1.593 ± 0.046	0.0ValXaa: 0.0 ± 0.0
Trp	1.352TrpAla: 1.352 ± 0.039	0.115TrpCys: 0.115 ± 0.011	0.659TrpAsp: 0.659 ± 0.03	0.595TrpGlu: 0.595 ± 0.024	0.533TrpPhe: 0.533 ± 0.021	0.854TrpGly: 0.854 ± 0.032	0.275TrpHis: 0.275 ± 0.02	0.702TrpIle: 0.702 ± 0.028	0.333TrpLys: 0.333 ± 0.019	1.517TrpLeu: 1.517 ± 0.049	0.337TrpMet: 0.337 ± 0.018	0.362TrpAsn: 0.362 ± 0.018	0.642TrpPro: 0.642 ± 0.022	0.519TrpGln: 0.519 ± 0.024	1.393TrpArg: 1.393 ± 0.037	0.926TrpSer: 0.926 ± 0.036	0.88TrpThr: 0.88 ± 0.032	0.806TrpVal: 0.806 ± 0.031	0.197TrpTrp: 0.197 ± 0.014	0.273TrpTyr: 0.273 ± 0.019	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.636TyrAla: 2.636 ± 0.058	0.214TyrCys: 0.214 ± 0.015	1.602TyrAsp: 1.602 ± 0.044	1.554TyrGlu: 1.554 ± 0.045	0.824TyrPhe: 0.824 ± 0.032	2.064TyrGly: 2.064 ± 0.05	0.445TyrHis: 0.445 ± 0.022	0.866TyrIle: 0.866 ± 0.032	0.544TyrLys: 0.544 ± 0.024	2.131TyrLeu: 2.131 ± 0.051	0.417TyrMet: 0.417 ± 0.023	0.519TyrAsn: 0.519 ± 0.026	0.999TyrPro: 0.999 ± 0.033	0.724TyrGln: 0.724 ± 0.028	1.748TyrArg: 1.748 ± 0.051	1.224TyrSer: 1.224 ± 0.042	1.097TyrThr: 1.097 ± 0.037	1.524TyrVal: 1.524 ± 0.04	0.373TyrTrp: 0.373 ± 0.021	0.561TyrTyr: 0.561 ± 0.028	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2862 proteins (911846 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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