Amino acid dipepetide frequency for Alternaria sp. MG1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	8.764AlaAla: 8.764 ± 0.097	1.074AlaCys: 1.074 ± 0.024	4.305AlaAsp: 4.305 ± 0.044	5.172AlaGlu: 5.172 ± 0.066	3.186AlaPhe: 3.186 ± 0.044	5.637AlaGly: 5.637 ± 0.063	1.834AlaHis: 1.834 ± 0.027	4.389AlaIle: 4.389 ± 0.044	4.428AlaLys: 4.428 ± 0.058	7.472AlaLeu: 7.472 ± 0.069	2.043AlaMet: 2.043 ± 0.031	3.138AlaAsn: 3.138 ± 0.042	4.961AlaPro: 4.961 ± 0.069	3.63AlaGln: 3.63 ± 0.055	4.837AlaArg: 4.837 ± 0.052	7.346AlaSer: 7.346 ± 0.069	5.517AlaThr: 5.517 ± 0.045	5.227AlaVal: 5.227 ± 0.054	1.173AlaTrp: 1.173 ± 0.027	2.344AlaTyr: 2.344 ± 0.031	0.002AlaXaa: 0.002 ± 0.001
Cys	0.934CysAla: 0.934 ± 0.02	0.246CysCys: 0.246 ± 0.012	0.671CysAsp: 0.671 ± 0.02	0.64CysGlu: 0.64 ± 0.017	0.573CysPhe: 0.573 ± 0.016	0.923CysGly: 0.923 ± 0.026	0.3CysHis: 0.3 ± 0.012	0.713CysIle: 0.713 ± 0.023	0.545CysLys: 0.545 ± 0.016	1.169CysLeu: 1.169 ± 0.024	0.3CysMet: 0.3 ± 0.011	0.488CysAsn: 0.488 ± 0.014	0.608CysPro: 0.608 ± 0.017	0.444CysGln: 0.444 ± 0.016	0.654CysArg: 0.654 ± 0.018	0.882CysSer: 0.882 ± 0.024	0.722CysThr: 0.722 ± 0.019	0.773CysVal: 0.773 ± 0.022	0.209CysTrp: 0.209 ± 0.009	0.396CysTyr: 0.396 ± 0.014	0.0CysXaa: 0.0 ± 0.0
Asp	5.094AspAla: 5.094 ± 0.053	0.629AspCys: 0.629 ± 0.02	4.377AspAsp: 4.377 ± 0.066	4.557AspGlu: 4.557 ± 0.057	2.24AspPhe: 2.24 ± 0.032	3.959AspGly: 3.959 ± 0.044	1.245AspHis: 1.245 ± 0.025	3.113AspIle: 3.113 ± 0.041	2.543AspLys: 2.543 ± 0.037	4.94AspLeu: 4.94 ± 0.054	1.444AspMet: 1.444 ± 0.025	1.952AspAsn: 1.952 ± 0.032	3.203AspPro: 3.203 ± 0.043	1.874AspGln: 1.874 ± 0.032	3.023AspArg: 3.023 ± 0.049	4.032AspSer: 4.032 ± 0.05	3.179AspThr: 3.179 ± 0.04	3.82AspVal: 3.82 ± 0.04	0.936AspTrp: 0.936 ± 0.023	1.679AspTyr: 1.679 ± 0.032	0.002AspXaa: 0.002 ± 0.001
Glu	5.551GluAla: 5.551 ± 0.069	0.663GluCys: 0.663 ± 0.02	4.4GluAsp: 4.4 ± 0.059	5.54GluGlu: 5.54 ± 0.081	1.873GluPhe: 1.873 ± 0.031	3.845GluGly: 3.845 ± 0.041	1.489GluHis: 1.489 ± 0.026	2.927GluIle: 2.927 ± 0.036	3.982GluLys: 3.982 ± 0.059	5.159GluLeu: 5.159 ± 0.064	1.485GluMet: 1.485 ± 0.029	2.253GluAsn: 2.253 ± 0.035	2.743GluPro: 2.743 ± 0.044	2.743GluGln: 2.743 ± 0.044	4.018GluArg: 4.018 ± 0.05	4.14GluSer: 4.14 ± 0.05	3.388GluThr: 3.388 ± 0.041	3.587GluVal: 3.587 ± 0.04	0.908GluTrp: 0.908 ± 0.022	1.753GluTyr: 1.753 ± 0.031	0.002GluXaa: 0.002 ± 0.001
Phe	3.15PheAla: 3.15 ± 0.048	0.558PheCys: 0.558 ± 0.016	2.368PheAsp: 2.368 ± 0.032	2.177PheGlu: 2.177 ± 0.035	1.605PhePhe: 1.605 ± 0.031	2.955PheGly: 2.955 ± 0.043	0.818PheHis: 0.818 ± 0.019	1.712PheIle: 1.712 ± 0.031	1.58PheLys: 1.58 ± 0.031	3.25PheLeu: 3.25 ± 0.048	0.803PheMet: 0.803 ± 0.018	1.467PheAsn: 1.467 ± 0.026	1.857PhePro: 1.857 ± 0.032	1.383PheGln: 1.383 ± 0.024	1.884PheArg: 1.884 ± 0.029	2.811PheSer: 2.811 ± 0.042	2.22PheThr: 2.22 ± 0.033	2.371PheVal: 2.371 ± 0.035	0.677PheTrp: 0.677 ± 0.019	1.09PheTyr: 1.09 ± 0.026	0.0PheXaa: 0.0 ± 0.0
Gly	5.276GlyAla: 5.276 ± 0.059	0.871GlyCys: 0.871 ± 0.026	3.604GlyAsp: 3.604 ± 0.04	3.597GlyGlu: 3.597 ± 0.051	2.738GlyPhe: 2.738 ± 0.041	5.76GlyGly: 5.76 ± 0.104	1.602GlyHis: 1.602 ± 0.031	3.495GlyIle: 3.495 ± 0.048	3.719GlyLys: 3.719 ± 0.046	5.678GlyLeu: 5.678 ± 0.06	1.714GlyMet: 1.714 ± 0.032	2.579GlyAsn: 2.579 ± 0.036	3.063GlyPro: 3.063 ± 0.047	2.54GlyGln: 2.54 ± 0.043	4.067GlyArg: 4.067 ± 0.049	5.392GlySer: 5.392 ± 0.064	3.936GlyThr: 3.936 ± 0.048	4.309GlyVal: 4.309 ± 0.053	1.24GlyTrp: 1.24 ± 0.023	2.184GlyTyr: 2.184 ± 0.038	0.003GlyXaa: 0.003 ± 0.001
His	1.876HisAla: 1.876 ± 0.029	0.354HisCys: 0.354 ± 0.01	1.387HisAsp: 1.387 ± 0.025	1.398HisGlu: 1.398 ± 0.028	0.937HisPhe: 0.937 ± 0.021	1.626HisGly: 1.626 ± 0.029	0.794HisHis: 0.794 ± 0.021	1.234HisIle: 1.234 ± 0.023	0.981HisLys: 0.981 ± 0.019	2.124HisLeu: 2.124 ± 0.034	0.564HisMet: 0.564 ± 0.016	0.864HisAsn: 0.864 ± 0.022	1.51HisPro: 1.51 ± 0.026	0.974HisGln: 0.974 ± 0.023	1.44HisArg: 1.44 ± 0.029	1.743HisSer: 1.743 ± 0.026	1.403HisThr: 1.403 ± 0.027	1.444HisVal: 1.444 ± 0.029	0.362HisTrp: 0.362 ± 0.012	0.685HisTyr: 0.685 ± 0.019	0.0HisXaa: 0.0 ± 0.0
Ile	4.367IleAla: 4.367 ± 0.052	0.733IleCys: 0.733 ± 0.019	2.912IleAsp: 2.912 ± 0.036	2.944IleGlu: 2.944 ± 0.037	1.907IlePhe: 1.907 ± 0.041	3.192IleGly: 3.192 ± 0.04	1.164IleHis: 1.164 ± 0.022	2.37IleIle: 2.37 ± 0.037	2.252IleLys: 2.252 ± 0.036	4.383IleLeu: 4.383 ± 0.054	1.086IleMet: 1.086 ± 0.024	1.808IleAsn: 1.808 ± 0.028	2.898IlePro: 2.898 ± 0.038	1.858IleGln: 1.858 ± 0.032	2.704IleArg: 2.704 ± 0.036	3.662IleSer: 3.662 ± 0.049	2.996IleThr: 2.996 ± 0.04	3.224IleVal: 3.224 ± 0.05	0.763IleTrp: 0.763 ± 0.018	1.409IleTyr: 1.409 ± 0.023	0.0IleXaa: 0.0 ± 0.0
Lys	4.533LysAla: 4.533 ± 0.05	0.511LysCys: 0.511 ± 0.016	3.138LysAsp: 3.138 ± 0.04	3.739LysGlu: 3.739 ± 0.046	1.455LysPhe: 1.455 ± 0.026	3.071LysGly: 3.071 ± 0.042	1.242LysHis: 1.242 ± 0.026	2.359LysIle: 2.359 ± 0.033	3.685LysLys: 3.685 ± 0.06	4.19LysLeu: 4.19 ± 0.05	1.105LysMet: 1.105 ± 0.024	1.852LysAsn: 1.852 ± 0.029	2.872LysPro: 2.872 ± 0.048	2.076LysGln: 2.076 ± 0.031	3.609LysArg: 3.609 ± 0.05	3.567LysSer: 3.567 ± 0.043	3.083LysThr: 3.083 ± 0.037	2.886LysVal: 2.886 ± 0.037	0.713LysTrp: 0.713 ± 0.018	1.415LysTyr: 1.415 ± 0.031	0.002LysXaa: 0.002 ± 0.001
Leu	7.552LeuAla: 7.552 ± 0.066	1.173LeuCys: 1.173 ± 0.027	5.056LeuAsp: 5.056 ± 0.05	5.461LeuGlu: 5.461 ± 0.062	3.156LeuPhe: 3.156 ± 0.045	5.685LeuGly: 5.685 ± 0.062	2.171LeuHis: 2.171 ± 0.036	3.711LeuIle: 3.711 ± 0.051	4.205LeuLys: 4.205 ± 0.049	7.879LeuLeu: 7.879 ± 0.082	1.747LeuMet: 1.747 ± 0.03	3.125LeuAsn: 3.125 ± 0.044	5.353LeuPro: 5.353 ± 0.056	3.884LeuGln: 3.884 ± 0.048	5.468LeuArg: 5.468 ± 0.057	6.869LeuSer: 6.869 ± 0.067	4.651LeuThr: 4.651 ± 0.05	5.14LeuVal: 5.14 ± 0.061	1.19LeuTrp: 1.19 ± 0.027	2.347LeuTyr: 2.347 ± 0.041	0.002LeuXaa: 0.002 ± 0.001
Met	2.212MetAla: 2.212 ± 0.032	0.249MetCys: 0.249 ± 0.01	1.358MetAsp: 1.358 ± 0.026	1.344MetGlu: 1.344 ± 0.027	0.834MetPhe: 0.834 ± 0.021	1.508MetGly: 1.508 ± 0.027	0.528MetHis: 0.528 ± 0.015	0.973MetIle: 0.973 ± 0.024	1.031MetLys: 1.031 ± 0.021	2.003MetLeu: 2.003 ± 0.034	0.632MetMet: 0.632 ± 0.02	0.866MetAsn: 0.866 ± 0.021	1.358MetPro: 1.358 ± 0.025	0.983MetGln: 0.983 ± 0.024	1.331MetArg: 1.331 ± 0.024	2.002MetSer: 2.002 ± 0.029	1.343MetThr: 1.343 ± 0.026	1.35MetVal: 1.35 ± 0.027	0.298MetTrp: 0.298 ± 0.012	0.606MetTyr: 0.606 ± 0.017	0.0MetXaa: 0.0 ± 0.0
Asn	3.368AsnAla: 3.368 ± 0.038	0.42AsnCys: 0.42 ± 0.014	2.139AsnAsp: 2.139 ± 0.036	2.157AsnGlu: 2.157 ± 0.031	1.435AsnPhe: 1.435 ± 0.027	3.054AsnGly: 3.054 ± 0.05	0.849AsnHis: 0.849 ± 0.019	2.064AsnIle: 2.064 ± 0.03	1.708AsnLys: 1.708 ± 0.03	3.177AsnLeu: 3.177 ± 0.037	0.939AsnMet: 0.939 ± 0.02	1.605AsnAsn: 1.605 ± 0.039	2.284AsnPro: 2.284 ± 0.031	1.362AsnGln: 1.362 ± 0.029	1.883AsnArg: 1.883 ± 0.033	2.702AsnSer: 2.702 ± 0.038	2.38AsnThr: 2.38 ± 0.032	2.48AsnVal: 2.48 ± 0.033	0.577AsnTrp: 0.577 ± 0.017	1.106AsnTyr: 1.106 ± 0.026	0.0AsnXaa: 0.0 ± 0.0
Pro	5.087ProAla: 5.087 ± 0.063	0.457ProCys: 0.457 ± 0.012	3.049ProAsp: 3.049 ± 0.044	3.691ProGlu: 3.691 ± 0.04	1.945ProPhe: 1.945 ± 0.032	3.649ProGly: 3.649 ± 0.049	1.294ProHis: 1.294 ± 0.025	2.528ProIle: 2.528 ± 0.037	2.893ProLys: 2.893 ± 0.043	4.472ProLeu: 4.472 ± 0.05	1.161ProMet: 1.161 ± 0.023	2.27ProAsn: 2.27 ± 0.039	4.83ProPro: 4.83 ± 0.094	2.502ProGln: 2.502 ± 0.045	3.193ProArg: 3.193 ± 0.044	5.747ProSer: 5.747 ± 0.082	4.151ProThr: 4.151 ± 0.058	3.446ProVal: 3.446 ± 0.045	0.719ProTrp: 0.719 ± 0.02	1.557ProTyr: 1.557 ± 0.029	0.002ProXaa: 0.002 ± 0.001
Gln	3.577GlnAla: 3.577 ± 0.051	0.466GlnCys: 0.466 ± 0.015	2.217GlnAsp: 2.217 ± 0.036	2.57GlnGlu: 2.57 ± 0.04	1.271GlnPhe: 1.271 ± 0.024	2.439GlnGly: 2.439 ± 0.035	1.177GlnHis: 1.177 ± 0.025	1.899GlnIle: 1.899 ± 0.03	2.103GlnLys: 2.103 ± 0.036	3.441GlnLeu: 3.441 ± 0.044	0.893GlnMet: 0.893 ± 0.021	1.651GlnAsn: 1.651 ± 0.032	2.502GlnPro: 2.502 ± 0.051	2.637GlnGln: 2.637 ± 0.076	2.777GlnArg: 2.777 ± 0.048	3.184GlnSer: 3.184 ± 0.046	2.35GlnThr: 2.35 ± 0.033	2.124GlnVal: 2.124 ± 0.024	0.595GlnTrp: 0.595 ± 0.019	1.269GlnTyr: 1.269 ± 0.025	0.002GlnXaa: 0.002 ± 0.001
Arg	4.55ArgAla: 4.55 ± 0.05	0.687ArgCys: 0.687 ± 0.018	3.308ArgAsp: 3.308 ± 0.053	3.711ArgGlu: 3.711 ± 0.051	2.037ArgPhe: 2.037 ± 0.032	3.555ArgGly: 3.555 ± 0.053	1.48ArgHis: 1.48 ± 0.028	2.919ArgIle: 2.919 ± 0.035	3.674ArgLys: 3.674 ± 0.043	5.111ArgLeu: 5.111 ± 0.06	1.386ArgMet: 1.386 ± 0.025	2.344ArgAsn: 2.344 ± 0.032	3.353ArgPro: 3.353 ± 0.055	2.584ArgGln: 2.584 ± 0.038	4.756ArgArg: 4.756 ± 0.069	4.724ArgSer: 4.724 ± 0.07	3.382ArgThr: 3.382 ± 0.043	3.183ArgVal: 3.183 ± 0.039	0.96ArgTrp: 0.96 ± 0.024	1.76ArgTyr: 1.76 ± 0.024	0.001ArgXaa: 0.001 ± 0.001
Ser	6.583SerAla: 6.583 ± 0.063	0.846SerCys: 0.846 ± 0.022	4.228SerAsp: 4.228 ± 0.054	4.137SerGlu: 4.137 ± 0.047	2.964SerPhe: 2.964 ± 0.038	5.328SerGly: 5.328 ± 0.058	1.876SerHis: 1.876 ± 0.036	3.923SerIle: 3.923 ± 0.046	3.841SerLys: 3.841 ± 0.048	6.766SerLeu: 6.766 ± 0.06	1.777SerMet: 1.777 ± 0.027	3.072SerAsn: 3.072 ± 0.037	5.151SerPro: 5.151 ± 0.083	3.222SerGln: 3.222 ± 0.049	4.675SerArg: 4.675 ± 0.067	8.18SerSer: 8.18 ± 0.119	5.703SerThr: 5.703 ± 0.067	4.51SerVal: 4.51 ± 0.047	1.152SerTrp: 1.152 ± 0.025	2.113SerTyr: 2.113 ± 0.035	0.0SerXaa: 0.0 ± 0.0
Thr	5.282ThrAla: 5.282 ± 0.052	0.793ThrCys: 0.793 ± 0.022	2.937ThrAsp: 2.937 ± 0.042	3.146ThrGlu: 3.146 ± 0.039	2.347ThrPhe: 2.347 ± 0.036	4.156ThrGly: 4.156 ± 0.051	1.326ThrHis: 1.326 ± 0.022	3.224ThrIle: 3.224 ± 0.041	2.856ThrLys: 2.856 ± 0.036	5.198ThrLeu: 5.198 ± 0.058	1.288ThrMet: 1.288 ± 0.023	2.279ThrAsn: 2.279 ± 0.033	4.439ThrPro: 4.439 ± 0.057	2.286ThrGln: 2.286 ± 0.036	3.222ThrArg: 3.222 ± 0.043	5.454ThrSer: 5.454 ± 0.06	4.405ThrThr: 4.405 ± 0.057	3.732ThrVal: 3.732 ± 0.051	0.892ThrTrp: 0.892 ± 0.018	1.715ThrTyr: 1.715 ± 0.032	0.002ThrXaa: 0.002 ± 0.001
Val	5.307ValAla: 5.307 ± 0.056	0.814ValCys: 0.814 ± 0.019	3.655ValAsp: 3.655 ± 0.036	3.946ValGlu: 3.946 ± 0.047	2.42ValPhe: 2.42 ± 0.039	3.95ValGly: 3.95 ± 0.051	1.42ValHis: 1.42 ± 0.029	2.81ValIle: 2.81 ± 0.043	2.986ValLys: 2.986 ± 0.038	5.445ValLeu: 5.445 ± 0.065	1.387ValMet: 1.387 ± 0.026	2.142ValAsn: 2.142 ± 0.035	3.512ValPro: 3.512 ± 0.038	2.434ValGln: 2.434 ± 0.031	3.352ValArg: 3.352 ± 0.044	4.4ValSer: 4.4 ± 0.046	3.532ValThr: 3.532 ± 0.042	4.214ValVal: 4.214 ± 0.054	0.895ValTrp: 0.895 ± 0.021	1.744ValTyr: 1.744 ± 0.03	0.001ValXaa: 0.001 ± 0.001
Trp	1.16TrpAla: 1.16 ± 0.024	0.204TrpCys: 0.204 ± 0.009	0.939TrpAsp: 0.939 ± 0.021	0.872TrpGlu: 0.872 ± 0.019	0.583TrpPhe: 0.583 ± 0.02	0.943TrpGly: 0.943 ± 0.024	0.362TrpHis: 0.362 ± 0.012	0.797TrpIle: 0.797 ± 0.023	0.87TrpLys: 0.87 ± 0.019	1.368TrpLeu: 1.368 ± 0.026	0.378TrpMet: 0.378 ± 0.013	0.686TrpAsn: 0.686 ± 0.02	0.628TrpPro: 0.628 ± 0.017	0.598TrpGln: 0.598 ± 0.018	0.95TrpArg: 0.95 ± 0.02	1.11TrpSer: 1.11 ± 0.026	0.924TrpThr: 0.924 ± 0.019	0.898TrpVal: 0.898 ± 0.023	0.292TrpTrp: 0.292 ± 0.011	0.465TrpTyr: 0.465 ± 0.014	0.001TrpXaa: 0.001 ± 0.001
Tyr	2.253TyrAla: 2.253 ± 0.036	0.44TyrCys: 0.44 ± 0.014	1.792TyrAsp: 1.792 ± 0.034	1.652TyrGlu: 1.652 ± 0.026	1.229TyrPhe: 1.229 ± 0.028	2.129TyrGly: 2.129 ± 0.04	0.729TyrHis: 0.729 ± 0.02	1.47TyrIle: 1.47 ± 0.028	1.222TyrLys: 1.222 ± 0.026	2.599TyrLeu: 2.599 ± 0.037	0.676TyrMet: 0.676 ± 0.017	1.244TyrAsn: 1.244 ± 0.027	1.517TyrPro: 1.517 ± 0.028	1.129TyrGln: 1.129 ± 0.021	1.62TyrArg: 1.62 ± 0.027	2.097TyrSer: 2.097 ± 0.029	1.713TyrThr: 1.713 ± 0.032	1.649TyrVal: 1.649 ± 0.031	0.477TyrTrp: 0.477 ± 0.013	0.974TyrTyr: 0.974 ± 0.024	0.001TyrXaa: 0.001 ± 0.001
Xaa	0.003XaaAla: 0.003 ± 0.001	0.0XaaCys: 0.0 ± 0.0	0.001XaaAsp: 0.001 ± 0.001	0.002XaaGlu: 0.002 ± 0.001	0.001XaaPhe: 0.001 ± 0.001	0.002XaaGly: 0.002 ± 0.001	0.001XaaHis: 0.001 ± 0.001	0.001XaaIle: 0.001 ± 0.001	0.0XaaLys: 0.0 ± 0.0	0.001XaaLeu: 0.001 ± 0.001	0.001XaaMet: 0.001 ± 0.001	0.001XaaAsn: 0.001 ± 0.001	0.003XaaPro: 0.003 ± 0.001	0.001XaaGln: 0.001 ± 0.001	0.001XaaArg: 0.001 ± 0.001	0.002XaaSer: 0.002 ± 0.001	0.003XaaThr: 0.003 ± 0.001	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.001	0.0XaaTyr: 0.0 ± 0.0	2.869XaaXaa: 2.869 ± 0.476

Statistics based on 4966 proteins (2220217 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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