Amino acid dipepetide frequency for Pseudoclavibacter sp. CFCC 13611

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	17.819AlaAla: 17.819 ± 0.253	0.644AlaCys: 0.644 ± 0.035	8.69AlaAsp: 8.69 ± 0.133	7.98AlaGlu: 7.98 ± 0.146	3.473AlaPhe: 3.473 ± 0.079	10.576AlaGly: 10.576 ± 0.165	2.725AlaHis: 2.725 ± 0.077	5.061AlaIle: 5.061 ± 0.1	3.291AlaLys: 3.291 ± 0.099	12.837AlaLeu: 12.837 ± 0.168	2.321AlaMet: 2.321 ± 0.056	2.398AlaAsn: 2.398 ± 0.061	5.411AlaPro: 5.411 ± 0.118	5.117AlaGln: 5.117 ± 0.098	7.971AlaArg: 7.971 ± 0.145	7.307AlaSer: 7.307 ± 0.125	6.623AlaThr: 6.623 ± 0.113	10.496AlaVal: 10.496 ± 0.15	1.564AlaTrp: 1.564 ± 0.051	2.094AlaTyr: 2.094 ± 0.062	0.0AlaXaa: 0.0 ± 0.0
Cys	0.646CysAla: 0.646 ± 0.033	0.066CysCys: 0.066 ± 0.011	0.317CysAsp: 0.317 ± 0.021	0.353CysGlu: 0.353 ± 0.023	0.176CysPhe: 0.176 ± 0.019	0.592CysGly: 0.592 ± 0.034	0.111CysHis: 0.111 ± 0.013	0.191CysIle: 0.191 ± 0.015	0.068CysLys: 0.068 ± 0.011	0.506CysLeu: 0.506 ± 0.029	0.105CysMet: 0.105 ± 0.012	0.114CysAsn: 0.114 ± 0.011	0.272CysPro: 0.272 ± 0.022	0.162CysGln: 0.162 ± 0.015	0.365CysArg: 0.365 ± 0.024	0.429CysSer: 0.429 ± 0.027	0.39CysThr: 0.39 ± 0.028	0.483CysVal: 0.483 ± 0.028	0.081CysTrp: 0.081 ± 0.012	0.102CysTyr: 0.102 ± 0.013	0.0CysXaa: 0.0 ± 0.0
Asp	8.524AspAla: 8.524 ± 0.131	0.272AspCys: 0.272 ± 0.022	4.731AspAsp: 4.731 ± 0.106	4.815AspGlu: 4.815 ± 0.1	1.763AspPhe: 1.763 ± 0.052	5.455AspGly: 5.455 ± 0.131	1.554AspHis: 1.554 ± 0.044	2.296AspIle: 2.296 ± 0.062	1.188AspLys: 1.188 ± 0.053	6.401AspLeu: 6.401 ± 0.094	0.79AspMet: 0.79 ± 0.035	1.01AspAsn: 1.01 ± 0.046	3.689AspPro: 3.689 ± 0.089	2.374AspGln: 2.374 ± 0.067	4.663AspArg: 4.663 ± 0.093	3.105AspSer: 3.105 ± 0.079	2.902AspThr: 2.902 ± 0.07	5.321AspVal: 5.321 ± 0.098	0.905AspTrp: 0.905 ± 0.036	1.273AspTyr: 1.273 ± 0.048	0.0AspXaa: 0.0 ± 0.0
Glu	6.776GluAla: 6.776 ± 0.137	0.299GluCys: 0.299 ± 0.023	2.372GluAsp: 2.372 ± 0.062	2.335GluGlu: 2.335 ± 0.074	1.743GluPhe: 1.743 ± 0.052	3.669GluGly: 3.669 ± 0.085	1.998GluHis: 1.998 ± 0.062	2.745GluIle: 2.745 ± 0.07	1.411GluLys: 1.411 ± 0.06	6.247GluLeu: 6.247 ± 0.123	0.928GluMet: 0.928 ± 0.033	1.387GluAsn: 1.387 ± 0.049	2.844GluPro: 2.844 ± 0.069	3.159GluGln: 3.159 ± 0.078	5.103GluArg: 5.103 ± 0.108	3.141GluSer: 3.141 ± 0.067	3.438GluThr: 3.438 ± 0.079	4.629GluVal: 4.629 ± 0.089	0.703GluTrp: 0.703 ± 0.034	1.14GluTyr: 1.14 ± 0.042	0.0GluXaa: 0.0 ± 0.0
Phe	4.027PheAla: 4.027 ± 0.076	0.219PheCys: 0.219 ± 0.018	2.449PheAsp: 2.449 ± 0.066	1.74PheGlu: 1.74 ± 0.053	1.083PhePhe: 1.083 ± 0.046	3.534PheGly: 3.534 ± 0.082	0.547PheHis: 0.547 ± 0.027	1.156PheIle: 1.156 ± 0.048	0.538PheLys: 0.538 ± 0.028	2.48PheLeu: 2.48 ± 0.073	0.488PheMet: 0.488 ± 0.025	0.704PheAsn: 0.704 ± 0.036	1.236PhePro: 1.236 ± 0.047	0.797PheGln: 0.797 ± 0.031	1.534PheArg: 1.534 ± 0.049	1.989PheSer: 1.989 ± 0.062	2.075PheThr: 2.075 ± 0.062	3.03PheVal: 3.03 ± 0.073	0.453PheTrp: 0.453 ± 0.03	0.65PheTyr: 0.65 ± 0.032	0.0PheXaa: 0.0 ± 0.0
Gly	9.509GlyAla: 9.509 ± 0.144	0.578GlyCys: 0.578 ± 0.031	5.025GlyAsp: 5.025 ± 0.109	4.72GlyGlu: 4.72 ± 0.082	3.123GlyPhe: 3.123 ± 0.074	6.705GlyGly: 6.705 ± 0.13	1.902GlyHis: 1.902 ± 0.058	4.338GlyIle: 4.338 ± 0.089	2.209GlyLys: 2.209 ± 0.07	8.414GlyLeu: 8.414 ± 0.124	1.79GlyMet: 1.79 ± 0.059	1.649GlyAsn: 1.649 ± 0.073	3.15GlyPro: 3.15 ± 0.073	3.224GlyGln: 3.224 ± 0.087	6.207GlyArg: 6.207 ± 0.108	5.548GlySer: 5.548 ± 0.12	5.166GlyThr: 5.166 ± 0.106	7.735GlyVal: 7.735 ± 0.121	1.471GlyTrp: 1.471 ± 0.06	2.021GlyTyr: 2.021 ± 0.061	0.0GlyXaa: 0.0 ± 0.0
His	2.549HisAla: 2.549 ± 0.071	0.107HisCys: 0.107 ± 0.014	1.772HisAsp: 1.772 ± 0.058	1.489HisGlu: 1.489 ± 0.048	0.637HisPhe: 0.637 ± 0.033	2.138HisGly: 2.138 ± 0.06	0.628HisHis: 0.628 ± 0.033	0.934HisIle: 0.934 ± 0.04	0.381HisLys: 0.381 ± 0.024	2.285HisLeu: 2.285 ± 0.057	0.426HisMet: 0.426 ± 0.026	0.434HisAsn: 0.434 ± 0.026	1.673HisPro: 1.673 ± 0.04	0.674HisGln: 0.674 ± 0.032	1.823HisArg: 1.823 ± 0.056	1.252HisSer: 1.252 ± 0.046	1.299HisThr: 1.299 ± 0.048	1.859HisVal: 1.859 ± 0.062	0.348HisTrp: 0.348 ± 0.022	0.476HisTyr: 0.476 ± 0.028	0.0HisXaa: 0.0 ± 0.0
Ile	6.501IleAla: 6.501 ± 0.113	0.314IleCys: 0.314 ± 0.022	3.808IleAsp: 3.808 ± 0.075	2.991IleGlu: 2.991 ± 0.077	1.272IlePhe: 1.272 ± 0.045	4.898IleGly: 4.898 ± 0.094	0.637IleHis: 0.637 ± 0.034	2.006IleIle: 2.006 ± 0.066	0.919IleLys: 0.919 ± 0.043	3.133IleLeu: 3.133 ± 0.077	0.761IleMet: 0.761 ± 0.034	1.057IleAsn: 1.057 ± 0.038	2.23IlePro: 2.23 ± 0.056	0.958IleGln: 0.958 ± 0.039	2.542IleArg: 2.542 ± 0.066	2.88IleSer: 2.88 ± 0.062	3.09IleThr: 3.09 ± 0.074	4.722IleVal: 4.722 ± 0.093	0.563IleTrp: 0.563 ± 0.027	0.772IleTyr: 0.772 ± 0.034	0.0IleXaa: 0.0 ± 0.0
Lys	2.805LysAla: 2.805 ± 0.09	0.086LysCys: 0.086 ± 0.012	1.201LysAsp: 1.201 ± 0.05	1.126LysGlu: 1.126 ± 0.052	0.604LysPhe: 0.604 ± 0.036	1.859LysGly: 1.859 ± 0.073	0.512LysHis: 0.512 ± 0.028	1.083LysIle: 1.083 ± 0.047	0.935LysLys: 0.935 ± 0.045	2.088LysLeu: 2.088 ± 0.058	0.456LysMet: 0.456 ± 0.026	0.601LysAsn: 0.601 ± 0.034	1.417LysPro: 1.417 ± 0.055	0.971LysGln: 0.971 ± 0.04	1.901LysArg: 1.901 ± 0.056	1.504LysSer: 1.504 ± 0.052	1.748LysThr: 1.748 ± 0.057	2.048LysVal: 2.048 ± 0.067	0.26LysTrp: 0.26 ± 0.019	0.535LysTyr: 0.535 ± 0.034	0.0LysXaa: 0.0 ± 0.0
Leu	12.666LeuAla: 12.666 ± 0.183	0.551LeuCys: 0.551 ± 0.029	6.563LeuAsp: 6.563 ± 0.13	4.889LeuGlu: 4.889 ± 0.105	2.986LeuPhe: 2.986 ± 0.084	8.596LeuGly: 8.596 ± 0.143	2.32LeuHis: 2.32 ± 0.053	4.986LeuIle: 4.986 ± 0.107	2.176LeuLys: 2.176 ± 0.068	10.363LeuLeu: 10.363 ± 0.186	1.665LeuMet: 1.665 ± 0.059	2.182LeuAsn: 2.182 ± 0.057	5.515LeuPro: 5.515 ± 0.083	3.371LeuGln: 3.371 ± 0.068	7.498LeuArg: 7.498 ± 0.153	6.204LeuSer: 6.204 ± 0.109	6.36LeuThr: 6.36 ± 0.098	8.707LeuVal: 8.707 ± 0.144	1.272LeuTrp: 1.272 ± 0.043	1.581LeuTyr: 1.581 ± 0.045	0.0LeuXaa: 0.0 ± 0.0
Met	1.874MetAla: 1.874 ± 0.053	0.108MetCys: 0.108 ± 0.014	0.599MetAsp: 0.599 ± 0.028	0.527MetGlu: 0.527 ± 0.025	0.525MetPhe: 0.525 ± 0.029	1.201MetGly: 1.201 ± 0.043	0.47MetHis: 0.47 ± 0.025	0.913MetIle: 0.913 ± 0.037	0.431MetLys: 0.431 ± 0.026	2.046MetLeu: 2.046 ± 0.072	0.306MetMet: 0.306 ± 0.023	0.522MetAsn: 0.522 ± 0.024	1.074MetPro: 1.074 ± 0.044	0.655MetGln: 0.655 ± 0.033	1.459MetArg: 1.459 ± 0.053	1.492MetSer: 1.492 ± 0.041	1.504MetThr: 1.504 ± 0.045	1.351MetVal: 1.351 ± 0.052	0.174MetTrp: 0.174 ± 0.017	0.287MetTyr: 0.287 ± 0.018	0.0MetXaa: 0.0 ± 0.0
Asn	2.638AsnAla: 2.638 ± 0.063	0.11AsnCys: 0.11 ± 0.013	1.569AsnAsp: 1.569 ± 0.068	1.237AsnGlu: 1.237 ± 0.045	0.59AsnPhe: 0.59 ± 0.032	2.128AsnGly: 2.128 ± 0.079	0.42AsnHis: 0.42 ± 0.027	0.968AsnIle: 0.968 ± 0.047	0.468AsnLys: 0.468 ± 0.029	2.06AsnLeu: 2.06 ± 0.048	0.384AsnMet: 0.384 ± 0.027	0.539AsnAsn: 0.539 ± 0.033	1.47AsnPro: 1.47 ± 0.056	0.709AsnGln: 0.709 ± 0.038	1.489AsnArg: 1.489 ± 0.052	1.129AsnSer: 1.129 ± 0.04	1.291AsnThr: 1.291 ± 0.051	1.853AsnVal: 1.853 ± 0.061	0.29AsnTrp: 0.29 ± 0.021	0.473AsnTyr: 0.473 ± 0.03	0.0AsnXaa: 0.0 ± 0.0
Pro	6.408ProAla: 6.408 ± 0.12	0.219ProCys: 0.219 ± 0.018	3.572ProAsp: 3.572 ± 0.073	3.742ProGlu: 3.742 ± 0.076	1.509ProPhe: 1.509 ± 0.042	4.381ProGly: 4.381 ± 0.092	1.149ProHis: 1.149 ± 0.045	2.106ProIle: 2.106 ± 0.058	1.525ProLys: 1.525 ± 0.047	4.44ProLeu: 4.44 ± 0.079	0.776ProMet: 0.776 ± 0.035	1.243ProAsn: 1.243 ± 0.047	1.722ProPro: 1.722 ± 0.067	2.043ProGln: 2.043 ± 0.061	2.904ProArg: 2.904 ± 0.072	3.171ProSer: 3.171 ± 0.071	3.392ProThr: 3.392 ± 0.083	4.522ProVal: 4.522 ± 0.088	0.745ProTrp: 0.745 ± 0.036	0.95ProTyr: 0.95 ± 0.039	0.0ProXaa: 0.0 ± 0.0
Gln	4.717GlnAla: 4.717 ± 0.091	0.165GlnCys: 0.165 ± 0.016	1.257GlnAsp: 1.257 ± 0.045	1.492GlnGlu: 1.492 ± 0.049	1.001GlnPhe: 1.001 ± 0.043	2.504GlnGly: 2.504 ± 0.063	1.072GlnHis: 1.072 ± 0.042	2.027GlnIle: 2.027 ± 0.057	0.88GlnLys: 0.88 ± 0.037	4.094GlnLeu: 4.094 ± 0.09	0.688GlnMet: 0.688 ± 0.03	0.902GlnAsn: 0.902 ± 0.045	2.239GlnPro: 2.239 ± 0.075	2.398GlnGln: 2.398 ± 0.085	3.327GlnArg: 3.327 ± 0.073	2.18GlnSer: 2.18 ± 0.057	2.557GlnThr: 2.557 ± 0.07	3.201GlnVal: 3.201 ± 0.065	0.533GlnTrp: 0.533 ± 0.027	0.691GlnTyr: 0.691 ± 0.033	0.0GlnXaa: 0.0 ± 0.0
Arg	7.809ArgAla: 7.809 ± 0.145	0.386ArgCys: 0.386 ± 0.026	4.15ArgAsp: 4.15 ± 0.1	4.117ArgGlu: 4.117 ± 0.096	2.414ArgPhe: 2.414 ± 0.063	4.836ArgGly: 4.836 ± 0.09	1.829ArgHis: 1.829 ± 0.053	3.621ArgIle: 3.621 ± 0.071	1.531ArgLys: 1.531 ± 0.051	7.876ArgLeu: 7.876 ± 0.155	1.625ArgMet: 1.625 ± 0.048	1.485ArgAsn: 1.485 ± 0.047	3.644ArgPro: 3.644 ± 0.083	2.779ArgGln: 2.779 ± 0.073	6.88ArgArg: 6.88 ± 0.15	4.428ArgSer: 4.428 ± 0.088	3.968ArgThr: 3.968 ± 0.075	5.669ArgVal: 5.669 ± 0.103	1.137ArgTrp: 1.137 ± 0.046	1.471ArgTyr: 1.471 ± 0.047	0.0ArgXaa: 0.0 ± 0.0
Ser	7.943SerAla: 7.943 ± 0.125	0.317SerCys: 0.317 ± 0.023	3.636SerAsp: 3.636 ± 0.09	3.171SerGlu: 3.171 ± 0.073	1.863SerPhe: 1.863 ± 0.056	6.154SerGly: 6.154 ± 0.123	1.272SerHis: 1.272 ± 0.045	2.791SerIle: 2.791 ± 0.07	1.506SerLys: 1.506 ± 0.048	5.774SerLeu: 5.774 ± 0.11	1.08SerMet: 1.08 ± 0.041	1.309SerAsn: 1.309 ± 0.045	3.118SerPro: 3.118 ± 0.067	2.04SerGln: 2.04 ± 0.057	3.982SerArg: 3.982 ± 0.091	3.965SerSer: 3.965 ± 0.102	4.045SerThr: 4.045 ± 0.09	5.091SerVal: 5.091 ± 0.105	0.911SerTrp: 0.911 ± 0.04	1.144SerTyr: 1.144 ± 0.041	0.0SerXaa: 0.0 ± 0.0
Thr	7.437ThrAla: 7.437 ± 0.119	0.291ThrCys: 0.291 ± 0.025	3.757ThrAsp: 3.757 ± 0.1	3.093ThrGlu: 3.093 ± 0.076	1.892ThrPhe: 1.892 ± 0.06	5.812ThrGly: 5.812 ± 0.104	1.32ThrHis: 1.32 ± 0.049	2.844ThrIle: 2.844 ± 0.076	1.563ThrLys: 1.563 ± 0.057	6.147ThrLeu: 6.147 ± 0.093	0.917ThrMet: 0.917 ± 0.042	1.371ThrAsn: 1.371 ± 0.061	3.812ThrPro: 3.812 ± 0.096	2.001ThrGln: 2.001 ± 0.06	3.434ThrArg: 3.434 ± 0.075	3.715ThrSer: 3.715 ± 0.073	3.931ThrThr: 3.931 ± 0.094	5.838ThrVal: 5.838 ± 0.096	0.793ThrTrp: 0.793 ± 0.037	1.252ThrTyr: 1.252 ± 0.044	0.0ThrXaa: 0.0 ± 0.0
Val	10.087ValAla: 10.087 ± 0.13	0.581ValCys: 0.581 ± 0.031	5.647ValAsp: 5.647 ± 0.093	4.665ValGlu: 4.665 ± 0.095	2.89ValPhe: 2.89 ± 0.069	6.678ValGly: 6.678 ± 0.102	1.979ValHis: 1.979 ± 0.054	4.698ValIle: 4.698 ± 0.098	1.979ValLys: 1.979 ± 0.075	9.432ValLeu: 9.432 ± 0.169	1.404ValMet: 1.404 ± 0.047	2.018ValAsn: 2.018 ± 0.063	4.368ValPro: 4.368 ± 0.074	2.946ValGln: 2.946 ± 0.067	5.856ValArg: 5.856 ± 0.097	5.615ValSer: 5.615 ± 0.094	5.687ValThr: 5.687 ± 0.112	8.384ValVal: 8.384 ± 0.126	1.081ValTrp: 1.081 ± 0.043	1.504ValTyr: 1.504 ± 0.05	0.0ValXaa: 0.0 ± 0.0
Trp	1.438TrpAla: 1.438 ± 0.048	0.105TrpCys: 0.105 ± 0.011	0.556TrpAsp: 0.556 ± 0.029	0.47TrpGlu: 0.47 ± 0.028	0.532TrpPhe: 0.532 ± 0.028	0.961TrpGly: 0.961 ± 0.039	0.371TrpHis: 0.371 ± 0.024	0.604TrpIle: 0.604 ± 0.03	0.335TrpLys: 0.335 ± 0.025	1.748TrpLeu: 1.748 ± 0.054	0.324TrpMet: 0.324 ± 0.023	0.468TrpAsn: 0.468 ± 0.027	0.68TrpPro: 0.68 ± 0.039	0.842TrpGln: 0.842 ± 0.036	1.155TrpArg: 1.155 ± 0.047	0.902TrpSer: 0.902 ± 0.039	0.682TrpThr: 0.682 ± 0.033	1.084TrpVal: 1.084 ± 0.044	0.293TrpTrp: 0.293 ± 0.025	0.324TrpTyr: 0.324 ± 0.024	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.231TyrAla: 2.231 ± 0.061	0.111TyrCys: 0.111 ± 0.012	1.36TyrAsp: 1.36 ± 0.051	1.116TyrGlu: 1.116 ± 0.047	0.655TyrPhe: 0.655 ± 0.032	1.806TyrGly: 1.806 ± 0.061	0.369TyrHis: 0.369 ± 0.025	0.685TyrIle: 0.685 ± 0.031	0.405TyrLys: 0.405 ± 0.025	2.075TyrLeu: 2.075 ± 0.064	0.284TyrMet: 0.284 ± 0.021	0.422TyrAsn: 0.422 ± 0.026	0.958TyrPro: 0.958 ± 0.04	0.706TyrGln: 0.706 ± 0.033	1.563TyrArg: 1.563 ± 0.05	1.156TyrSer: 1.156 ± 0.04	1.069TyrThr: 1.069 ± 0.041	1.474TyrVal: 1.474 ± 0.046	0.296TyrTrp: 0.296 ± 0.023	0.456TyrTyr: 0.456 ± 0.026	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 1915 proteins (666035 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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