Amino acid dipepetide frequency for Halomonas sp. JB37

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	11.698AlaAla: 11.698 ± 0.13	1.203AlaCys: 1.203 ± 0.035	5.5AlaAsp: 5.5 ± 0.068	6.412AlaGlu: 6.412 ± 0.099	4.144AlaPhe: 4.144 ± 0.066	8.415AlaGly: 8.415 ± 0.103	2.406AlaHis: 2.406 ± 0.052	6.091AlaIle: 6.091 ± 0.081	3.301AlaLys: 3.301 ± 0.06	14.016AlaLeu: 14.016 ± 0.151	3.251AlaMet: 3.251 ± 0.058	3.184AlaAsn: 3.184 ± 0.057	4.473AlaPro: 4.473 ± 0.068	4.64AlaGln: 4.64 ± 0.078	6.368AlaArg: 6.368 ± 0.085	6.566AlaSer: 6.566 ± 0.073	5.485AlaThr: 5.485 ± 0.075	7.369AlaVal: 7.369 ± 0.083	1.735AlaTrp: 1.735 ± 0.042	2.519AlaTyr: 2.519 ± 0.045	0.0AlaXaa: 0.0 ± 0.0
Cys	0.931CysAla: 0.931 ± 0.029	0.137CysCys: 0.137 ± 0.012	0.598CysAsp: 0.598 ± 0.021	0.529CysGlu: 0.529 ± 0.022	0.363CysPhe: 0.363 ± 0.017	0.888CysGly: 0.888 ± 0.031	0.303CysHis: 0.303 ± 0.017	0.428CysIle: 0.428 ± 0.021	0.222CysLys: 0.222 ± 0.014	1.053CysLeu: 1.053 ± 0.035	0.222CysMet: 0.222 ± 0.013	0.228CysAsn: 0.228 ± 0.016	0.478CysPro: 0.478 ± 0.024	0.421CysGln: 0.421 ± 0.019	0.572CysArg: 0.572 ± 0.022	0.545CysSer: 0.545 ± 0.024	0.426CysThr: 0.426 ± 0.021	0.714CysVal: 0.714 ± 0.027	0.126CysTrp: 0.126 ± 0.011	0.292CysTyr: 0.292 ± 0.016	0.0CysXaa: 0.0 ± 0.0
Asp	6.172AspAla: 6.172 ± 0.079	0.424AspCys: 0.424 ± 0.021	3.44AspAsp: 3.44 ± 0.066	3.808AspGlu: 3.808 ± 0.067	1.997AspPhe: 1.997 ± 0.044	4.028AspGly: 4.028 ± 0.063	1.346AspHis: 1.346 ± 0.037	3.377AspIle: 3.377 ± 0.055	1.658AspLys: 1.658 ± 0.044	4.857AspLeu: 4.857 ± 0.071	1.382AspMet: 1.382 ± 0.037	1.726AspAsn: 1.726 ± 0.043	2.66AspPro: 2.66 ± 0.054	2.234AspGln: 2.234 ± 0.051	2.871AspArg: 2.871 ± 0.056	2.943AspSer: 2.943 ± 0.059	2.887AspThr: 2.887 ± 0.054	4.244AspVal: 4.244 ± 0.068	0.864AspTrp: 0.864 ± 0.028	1.711AspTyr: 1.711 ± 0.039	0.0AspXaa: 0.0 ± 0.0
Glu	6.823GluAla: 6.823 ± 0.094	0.438GluCys: 0.438 ± 0.02	2.745GluAsp: 2.745 ± 0.051	3.647GluGlu: 3.647 ± 0.073	1.702GluPhe: 1.702 ± 0.036	4.31GluGly: 4.31 ± 0.065	1.818GluHis: 1.818 ± 0.045	2.989GluIle: 2.989 ± 0.058	2.075GluLys: 2.075 ± 0.052	6.423GluLeu: 6.423 ± 0.093	1.571GluMet: 1.571 ± 0.038	1.816GluAsn: 1.816 ± 0.042	2.47GluPro: 2.47 ± 0.061	3.613GluGln: 3.613 ± 0.067	5.158GluArg: 5.158 ± 0.08	3.244GluSer: 3.244 ± 0.048	3.087GluThr: 3.087 ± 0.06	3.95GluVal: 3.95 ± 0.067	0.905GluTrp: 0.905 ± 0.028	1.272GluTyr: 1.272 ± 0.041	0.0GluXaa: 0.0 ± 0.0
Phe	3.667PheAla: 3.667 ± 0.068	0.407PheCys: 0.407 ± 0.019	2.448PheAsp: 2.448 ± 0.046	2.134PheGlu: 2.134 ± 0.043	1.409PhePhe: 1.409 ± 0.043	3.274PheGly: 3.274 ± 0.06	0.804PheHis: 0.804 ± 0.025	2.189PheIle: 2.189 ± 0.049	1.143PheLys: 1.143 ± 0.033	3.309PheLeu: 3.309 ± 0.062	0.972PheMet: 0.972 ± 0.03	1.299PheAsn: 1.299 ± 0.038	1.456PhePro: 1.456 ± 0.031	1.214PheGln: 1.214 ± 0.031	1.699PheArg: 1.699 ± 0.041	2.67PheSer: 2.67 ± 0.049	2.082PheThr: 2.082 ± 0.046	2.526PheVal: 2.526 ± 0.051	0.507PheTrp: 0.507 ± 0.023	1.053PheTyr: 1.053 ± 0.031	0.0PheXaa: 0.0 ± 0.0
Gly	7.229GlyAla: 7.229 ± 0.101	0.914GlyCys: 0.914 ± 0.033	4.164GlyAsp: 4.164 ± 0.069	4.936GlyGlu: 4.936 ± 0.075	3.272GlyPhe: 3.272 ± 0.053	6.148GlyGly: 6.148 ± 0.086	1.908GlyHis: 1.908 ± 0.042	4.851GlyIle: 4.851 ± 0.076	2.907GlyLys: 2.907 ± 0.062	8.751GlyLeu: 8.751 ± 0.106	2.356GlyMet: 2.356 ± 0.045	2.265GlyAsn: 2.265 ± 0.046	2.52GlyPro: 2.52 ± 0.048	3.208GlyGln: 3.208 ± 0.06	4.553GlyArg: 4.553 ± 0.067	4.616GlySer: 4.616 ± 0.073	3.787GlyThr: 3.787 ± 0.057	6.213GlyVal: 6.213 ± 0.081	1.324GlyTrp: 1.324 ± 0.038	2.442GlyTyr: 2.442 ± 0.048	0.0GlyXaa: 0.0 ± 0.0
His	2.517HisAla: 2.517 ± 0.051	0.313HisCys: 0.313 ± 0.017	1.346HisAsp: 1.346 ± 0.033	1.23HisGlu: 1.23 ± 0.037	1.082HisPhe: 1.082 ± 0.033	1.996HisGly: 1.996 ± 0.048	0.795HisHis: 0.795 ± 0.029	1.111HisIle: 1.111 ± 0.032	0.612HisLys: 0.612 ± 0.027	2.636HisLeu: 2.636 ± 0.054	0.52HisMet: 0.52 ± 0.022	0.656HisAsn: 0.656 ± 0.025	1.425HisPro: 1.425 ± 0.047	1.193HisGln: 1.193 ± 0.039	1.545HisArg: 1.545 ± 0.041	1.383HisSer: 1.383 ± 0.038	1.138HisThr: 1.138 ± 0.032	1.526HisVal: 1.526 ± 0.036	0.43HisTrp: 0.43 ± 0.019	0.84HisTyr: 0.84 ± 0.025	0.0HisXaa: 0.0 ± 0.0
Ile	6.598IleAla: 6.598 ± 0.084	0.473IleCys: 0.473 ± 0.019	3.565IleAsp: 3.565 ± 0.064	3.763IleGlu: 3.763 ± 0.065	1.767IlePhe: 1.767 ± 0.043	4.773IleGly: 4.773 ± 0.082	1.093IleHis: 1.093 ± 0.028	2.71IleIle: 2.71 ± 0.063	1.679IleLys: 1.679 ± 0.043	4.342IleLeu: 4.342 ± 0.072	1.189IleMet: 1.189 ± 0.034	2.053IleAsn: 2.053 ± 0.042	2.429IlePro: 2.429 ± 0.05	1.674IleGln: 1.674 ± 0.048	2.799IleArg: 2.799 ± 0.053	3.468IleSer: 3.468 ± 0.061	3.115IleThr: 3.115 ± 0.055	3.797IleVal: 3.797 ± 0.065	0.528IleTrp: 0.528 ± 0.024	1.2IleTyr: 1.2 ± 0.032	0.0IleXaa: 0.0 ± 0.0
Lys	3.509LysAla: 3.509 ± 0.078	0.187LysCys: 0.187 ± 0.015	1.416LysAsp: 1.416 ± 0.044	1.773LysGlu: 1.773 ± 0.051	0.686LysPhe: 0.686 ± 0.028	2.417LysGly: 2.417 ± 0.05	0.749LysHis: 0.749 ± 0.026	1.406LysIle: 1.406 ± 0.039	1.251LysLys: 1.251 ± 0.046	3.169LysLeu: 3.169 ± 0.06	0.763LysMet: 0.763 ± 0.029	0.823LysAsn: 0.823 ± 0.033	1.705LysPro: 1.705 ± 0.045	1.512LysGln: 1.512 ± 0.044	2.55LysArg: 2.55 ± 0.049	1.686LysSer: 1.686 ± 0.038	1.695LysThr: 1.695 ± 0.044	2.266LysVal: 2.266 ± 0.048	0.325LysTrp: 0.325 ± 0.016	0.557LysTyr: 0.557 ± 0.024	0.0LysXaa: 0.0 ± 0.0
Leu	13.697LeuAla: 13.697 ± 0.137	1.162LeuCys: 1.162 ± 0.035	6.245LeuAsp: 6.245 ± 0.077	6.748LeuGlu: 6.748 ± 0.093	3.98LeuPhe: 3.98 ± 0.062	8.657LeuGly: 8.657 ± 0.103	2.266LeuHis: 2.266 ± 0.051	6.098LeuIle: 6.098 ± 0.095	3.693LeuLys: 3.693 ± 0.063	12.424LeuLeu: 12.424 ± 0.161	3.16LeuMet: 3.16 ± 0.056	3.629LeuAsn: 3.629 ± 0.057	6.266LeuPro: 6.266 ± 0.075	3.469LeuGln: 3.469 ± 0.057	6.348LeuArg: 6.348 ± 0.088	7.665LeuSer: 7.665 ± 0.096	6.234LeuThr: 6.234 ± 0.073	7.682LeuVal: 7.682 ± 0.087	1.423LeuTrp: 1.423 ± 0.033	2.407LeuTyr: 2.407 ± 0.052	0.0LeuXaa: 0.0 ± 0.0
Met	3.312MetAla: 3.312 ± 0.051	0.194MetCys: 0.194 ± 0.014	1.106MetAsp: 1.106 ± 0.032	1.2MetGlu: 1.2 ± 0.035	0.768MetPhe: 0.768 ± 0.03	2.086MetGly: 2.086 ± 0.047	0.544MetHis: 0.544 ± 0.022	1.413MetIle: 1.413 ± 0.034	0.891MetLys: 0.891 ± 0.028	3.094MetLeu: 3.094 ± 0.052	0.74MetMet: 0.74 ± 0.028	0.82MetAsn: 0.82 ± 0.026	1.504MetPro: 1.504 ± 0.039	1.133MetGln: 1.133 ± 0.033	1.666MetArg: 1.666 ± 0.038	1.918MetSer: 1.918 ± 0.042	1.745MetThr: 1.745 ± 0.036	1.904MetVal: 1.904 ± 0.05	0.221MetTrp: 0.221 ± 0.014	0.371MetTyr: 0.371 ± 0.018	0.0MetXaa: 0.0 ± 0.0
Asn	3.506AsnAla: 3.506 ± 0.06	0.258AsnCys: 0.258 ± 0.015	1.863AsnAsp: 1.863 ± 0.049	1.705AsnGlu: 1.705 ± 0.039	0.987AsnPhe: 0.987 ± 0.03	2.432AsnGly: 2.432 ± 0.051	0.692AsnHis: 0.692 ± 0.025	1.657AsnIle: 1.657 ± 0.04	0.812AsnLys: 0.812 ± 0.026	2.877AsnLeu: 2.877 ± 0.053	0.681AsnMet: 0.681 ± 0.026	0.977AsnAsn: 0.977 ± 0.033	1.75AsnPro: 1.75 ± 0.039	1.256AsnGln: 1.256 ± 0.038	1.829AsnArg: 1.829 ± 0.035	1.626AsnSer: 1.626 ± 0.039	1.548AsnThr: 1.548 ± 0.041	2.307AsnVal: 2.307 ± 0.042	0.408AsnTrp: 0.408 ± 0.019	0.809AsnTyr: 0.809 ± 0.024	0.0AsnXaa: 0.0 ± 0.0
Pro	4.764ProAla: 4.764 ± 0.075	0.331ProCys: 0.331 ± 0.018	2.932ProAsp: 2.932 ± 0.055	3.513ProGlu: 3.513 ± 0.059	1.826ProPhe: 1.826 ± 0.038	3.754ProGly: 3.754 ± 0.062	1.113ProHis: 1.113 ± 0.027	2.355ProIle: 2.355 ± 0.047	1.365ProLys: 1.365 ± 0.038	5.663ProLeu: 5.663 ± 0.072	1.291ProMet: 1.291 ± 0.033	1.511ProAsn: 1.511 ± 0.039	1.947ProPro: 1.947 ± 0.055	1.831ProGln: 1.831 ± 0.041	2.401ProArg: 2.401 ± 0.045	2.97ProSer: 2.97 ± 0.063	2.376ProThr: 2.376 ± 0.041	3.578ProVal: 3.578 ± 0.062	0.792ProTrp: 0.792 ± 0.033	1.095ProTyr: 1.095 ± 0.031	0.0ProXaa: 0.0 ± 0.0
Gln	5.556GlnAla: 5.556 ± 0.083	0.355GlnCys: 0.355 ± 0.017	1.722GlnAsp: 1.722 ± 0.037	2.253GlnGlu: 2.253 ± 0.054	1.175GlnPhe: 1.175 ± 0.034	3.24GlnGly: 3.24 ± 0.054	1.271GlnHis: 1.271 ± 0.032	1.721GlnIle: 1.721 ± 0.038	1.087GlnLys: 1.087 ± 0.034	5.073GlnLeu: 5.073 ± 0.089	1.012GlnMet: 1.012 ± 0.032	0.984GlnAsn: 0.984 ± 0.029	2.138GlnPro: 2.138 ± 0.046	2.739GlnGln: 2.739 ± 0.073	3.728GlnArg: 3.728 ± 0.066	2.21GlnSer: 2.21 ± 0.052	1.895GlnThr: 1.895 ± 0.044	3.017GlnVal: 3.017 ± 0.052	0.764GlnTrp: 0.764 ± 0.03	0.829GlnTyr: 0.829 ± 0.022	0.0GlnXaa: 0.0 ± 0.0
Arg	5.37ArgAla: 5.37 ± 0.082	0.577ArgCys: 0.577 ± 0.02	3.636ArgAsp: 3.636 ± 0.067	4.269ArgGlu: 4.269 ± 0.066	2.787ArgPhe: 2.787 ± 0.049	3.894ArgGly: 3.894 ± 0.064	1.965ArgHis: 1.965 ± 0.05	3.18ArgIle: 3.18 ± 0.057	1.777ArgLys: 1.777 ± 0.046	8.159ArgLeu: 8.159 ± 0.115	1.606ArgMet: 1.606 ± 0.035	1.644ArgAsn: 1.644 ± 0.038	2.452ArgPro: 2.452 ± 0.053	3.203ArgGln: 3.203 ± 0.063	4.273ArgArg: 4.273 ± 0.076	3.184ArgSer: 3.184 ± 0.054	2.632ArgThr: 2.632 ± 0.05	4.175ArgVal: 4.175 ± 0.063	1.067ArgTrp: 1.067 ± 0.033	2.147ArgTyr: 2.147 ± 0.045	0.0ArgXaa: 0.0 ± 0.0
Ser	6.233SerAla: 6.233 ± 0.087	0.486SerCys: 0.486 ± 0.023	3.404SerAsp: 3.404 ± 0.062	3.471SerGlu: 3.471 ± 0.064	2.224SerPhe: 2.224 ± 0.043	5.383SerGly: 5.383 ± 0.067	1.442SerHis: 1.442 ± 0.035	2.984SerIle: 2.984 ± 0.059	1.614SerLys: 1.614 ± 0.038	7.012SerLeu: 7.012 ± 0.092	1.56SerMet: 1.56 ± 0.039	1.698SerAsn: 1.698 ± 0.038	2.866SerPro: 2.866 ± 0.057	2.67SerGln: 2.67 ± 0.054	3.682SerArg: 3.682 ± 0.059	3.577SerSer: 3.577 ± 0.065	3.05SerThr: 3.05 ± 0.05	4.404SerVal: 4.404 ± 0.066	0.82SerTrp: 0.82 ± 0.027	1.435SerTyr: 1.435 ± 0.038	0.0SerXaa: 0.0 ± 0.0
Thr	5.412ThrAla: 5.412 ± 0.072	0.443ThrCys: 0.443 ± 0.024	2.585ThrAsp: 2.585 ± 0.048	2.384ThrGlu: 2.384 ± 0.052	1.951ThrPhe: 1.951 ± 0.04	4.162ThrGly: 4.162 ± 0.063	1.299ThrHis: 1.299 ± 0.044	2.356ThrIle: 2.356 ± 0.049	1.152ThrLys: 1.152 ± 0.036	7.531ThrLeu: 7.531 ± 0.093	1.155ThrMet: 1.155 ± 0.029	1.388ThrAsn: 1.388 ± 0.034	3.598ThrPro: 3.598 ± 0.054	2.212ThrGln: 2.212 ± 0.045	3.1ThrArg: 3.1 ± 0.05	2.99ThrSer: 2.99 ± 0.055	2.718ThrThr: 2.718 ± 0.052	3.413ThrVal: 3.413 ± 0.053	0.758ThrTrp: 0.758 ± 0.028	1.182ThrTyr: 1.182 ± 0.035	0.0ThrXaa: 0.0 ± 0.0
Val	8.099ValAla: 8.099 ± 0.098	0.683ValCys: 0.683 ± 0.024	4.037ValAsp: 4.037 ± 0.062	4.351ValGlu: 4.351 ± 0.057	2.597ValPhe: 2.597 ± 0.048	5.521ValGly: 5.521 ± 0.071	1.42ValHis: 1.42 ± 0.037	4.357ValIle: 4.357 ± 0.067	2.194ValLys: 2.194 ± 0.059	7.618ValLeu: 7.618 ± 0.093	2.249ValMet: 2.249 ± 0.05	2.234ValAsn: 2.234 ± 0.048	3.217ValPro: 3.217 ± 0.057	2.207ValGln: 2.207 ± 0.048	3.847ValArg: 3.847 ± 0.068	4.543ValSer: 4.543 ± 0.066	4.082ValThr: 4.082 ± 0.065	5.743ValVal: 5.743 ± 0.088	0.905ValTrp: 0.905 ± 0.032	1.569ValTyr: 1.569 ± 0.037	0.0ValXaa: 0.0 ± 0.0
Trp	1.171TrpAla: 1.171 ± 0.035	0.19TrpCys: 0.19 ± 0.015	0.577TrpAsp: 0.577 ± 0.025	0.706TrpGlu: 0.706 ± 0.024	0.538TrpPhe: 0.538 ± 0.024	0.938TrpGly: 0.938 ± 0.031	0.408TrpHis: 0.408 ± 0.021	0.652TrpIle: 0.652 ± 0.027	0.426TrpLys: 0.426 ± 0.021	2.361TrpLeu: 2.361 ± 0.051	0.407TrpMet: 0.407 ± 0.02	0.403TrpAsn: 0.403 ± 0.02	0.724TrpPro: 0.724 ± 0.029	1.088TrpGln: 1.088 ± 0.035	1.078TrpArg: 1.078 ± 0.035	0.751TrpSer: 0.751 ± 0.027	0.558TrpThr: 0.558 ± 0.024	1.022TrpVal: 1.022 ± 0.028	0.291TrpTrp: 0.291 ± 0.017	0.33TrpTyr: 0.33 ± 0.018	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.51TyrAla: 2.51 ± 0.047	0.301TyrCys: 0.301 ± 0.016	1.301TyrAsp: 1.301 ± 0.042	1.225TyrGlu: 1.225 ± 0.03	1.008TyrPhe: 1.008 ± 0.032	2.049TyrGly: 2.049 ± 0.048	0.655TyrHis: 0.655 ± 0.025	1.089TyrIle: 1.089 ± 0.031	0.588TyrLys: 0.588 ± 0.024	2.886TyrLeu: 2.886 ± 0.049	0.538TyrMet: 0.538 ± 0.023	0.641TyrAsn: 0.641 ± 0.025	1.329TyrPro: 1.329 ± 0.031	1.252TyrGln: 1.252 ± 0.03	1.931TyrArg: 1.931 ± 0.039	1.459TyrSer: 1.459 ± 0.038	1.253TyrThr: 1.253 ± 0.036	1.62TyrVal: 1.62 ± 0.042	0.426TyrTrp: 0.426 ± 0.021	0.689TyrTyr: 0.689 ± 0.027	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3369 proteins (1110597 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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