Amino acid dipepetide frequency for Jannaschia seosinensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	18.428AlaAla: 18.428 ± 0.228	1.29AlaCys: 1.29 ± 0.039	7.335AlaAsp: 7.335 ± 0.088	8.99AlaGlu: 8.99 ± 0.121	4.356AlaPhe: 4.356 ± 0.067	10.611AlaGly: 10.611 ± 0.128	2.464AlaHis: 2.464 ± 0.049	5.861AlaIle: 5.861 ± 0.087	3.316AlaLys: 3.316 ± 0.068	13.831AlaLeu: 13.831 ± 0.149	3.906AlaMet: 3.906 ± 0.063	2.561AlaAsn: 2.561 ± 0.052	6.479AlaPro: 6.479 ± 0.09	4.082AlaGln: 4.082 ± 0.07	10.772AlaArg: 10.772 ± 0.13	5.671AlaSer: 5.671 ± 0.079	6.284AlaThr: 6.284 ± 0.071	8.666AlaVal: 8.666 ± 0.109	1.635AlaTrp: 1.635 ± 0.043	2.278AlaTyr: 2.278 ± 0.046	0.001AlaXaa: 0.001 ± 0.001
Cys	1.163CysAla: 1.163 ± 0.035	0.098CysCys: 0.098 ± 0.009	0.66CysAsp: 0.66 ± 0.024	0.521CysGlu: 0.521 ± 0.023	0.331CysPhe: 0.331 ± 0.019	0.893CysGly: 0.893 ± 0.036	0.255CysHis: 0.255 ± 0.015	0.392CysIle: 0.392 ± 0.019	0.174CysLys: 0.174 ± 0.011	0.828CysLeu: 0.828 ± 0.029	0.171CysMet: 0.171 ± 0.013	0.183CysAsn: 0.183 ± 0.015	0.585CysPro: 0.585 ± 0.027	0.242CysGln: 0.242 ± 0.016	0.712CysArg: 0.712 ± 0.025	0.478CysSer: 0.478 ± 0.023	0.429CysThr: 0.429 ± 0.019	0.609CysVal: 0.609 ± 0.025	0.142CysTrp: 0.142 ± 0.013	0.166CysTyr: 0.166 ± 0.011	0.0CysXaa: 0.0 ± 0.0
Asp	8.488AspAla: 8.488 ± 0.106	0.456AspCys: 0.456 ± 0.023	3.666AspAsp: 3.666 ± 0.069	3.756AspGlu: 3.756 ± 0.07	2.046AspPhe: 2.046 ± 0.041	5.927AspGly: 5.927 ± 0.084	1.354AspHis: 1.354 ± 0.037	2.771AspIle: 2.771 ± 0.052	1.3AspLys: 1.3 ± 0.036	6.955AspLeu: 6.955 ± 0.092	1.495AspMet: 1.495 ± 0.035	1.12AspAsn: 1.12 ± 0.031	3.975AspPro: 3.975 ± 0.059	1.499AspGln: 1.499 ± 0.043	5.403AspArg: 5.403 ± 0.064	1.887AspSer: 1.887 ± 0.042	2.955AspThr: 2.955 ± 0.059	4.416AspVal: 4.416 ± 0.071	1.325AspTrp: 1.325 ± 0.035	1.316AspTyr: 1.316 ± 0.036	0.0AspXaa: 0.0 ± 0.0
Glu	9.149GluAla: 9.149 ± 0.124	0.395GluCys: 0.395 ± 0.018	3.336GluAsp: 3.336 ± 0.057	3.899GluGlu: 3.899 ± 0.077	1.704GluPhe: 1.704 ± 0.042	5.164GluGly: 5.164 ± 0.067	1.205GluHis: 1.205 ± 0.031	3.721GluIle: 3.721 ± 0.061	1.86GluLys: 1.86 ± 0.053	4.826GluLeu: 4.826 ± 0.076	1.983GluMet: 1.983 ± 0.05	1.603GluAsn: 1.603 ± 0.041	2.755GluPro: 2.755 ± 0.057	1.786GluGln: 1.786 ± 0.039	5.399GluArg: 5.399 ± 0.081	2.14GluSer: 2.14 ± 0.042	4.207GluThr: 4.207 ± 0.067	4.676GluVal: 4.676 ± 0.074	0.904GluTrp: 0.904 ± 0.032	0.969GluTyr: 0.969 ± 0.03	0.0GluXaa: 0.0 ± 0.0
Phe	4.511PheAla: 4.511 ± 0.07	0.387PheCys: 0.387 ± 0.019	2.867PheAsp: 2.867 ± 0.052	2.102PheGlu: 2.102 ± 0.044	1.252PhePhe: 1.252 ± 0.044	3.457PheGly: 3.457 ± 0.063	0.726PheHis: 0.726 ± 0.021	1.337PheIle: 1.337 ± 0.038	0.777PheLys: 0.777 ± 0.03	3.334PheLeu: 3.334 ± 0.064	0.722PheMet: 0.722 ± 0.023	0.848PheAsn: 0.848 ± 0.028	1.554PhePro: 1.554 ± 0.04	0.88PheGln: 0.88 ± 0.032	2.542PheArg: 2.542 ± 0.047	1.8PheSer: 1.8 ± 0.041	1.895PheThr: 1.895 ± 0.041	2.687PheVal: 2.687 ± 0.056	0.529PheTrp: 0.529 ± 0.025	0.803PheTyr: 0.803 ± 0.029	0.0PheXaa: 0.0 ± 0.0
Gly	10.114GlyAla: 10.114 ± 0.127	0.898GlyCys: 0.898 ± 0.032	4.809GlyAsp: 4.809 ± 0.077	4.92GlyGlu: 4.92 ± 0.07	3.497GlyPhe: 3.497 ± 0.067	7.508GlyGly: 7.508 ± 0.129	2.05GlyHis: 2.05 ± 0.042	4.226GlyIle: 4.226 ± 0.07	2.561GlyLys: 2.561 ± 0.057	9.088GlyLeu: 9.088 ± 0.104	2.559GlyMet: 2.559 ± 0.048	1.887GlyAsn: 1.887 ± 0.05	3.912GlyPro: 3.912 ± 0.068	2.764GlyGln: 2.764 ± 0.049	6.979GlyArg: 6.979 ± 0.086	3.911GlySer: 3.911 ± 0.07	4.808GlyThr: 4.808 ± 0.071	6.17GlyVal: 6.17 ± 0.092	1.577GlyTrp: 1.577 ± 0.037	2.018GlyTyr: 2.018 ± 0.045	0.0GlyXaa: 0.0 ± 0.0
His	2.483HisAla: 2.483 ± 0.052	0.212HisCys: 0.212 ± 0.015	1.451HisAsp: 1.451 ± 0.042	1.24HisGlu: 1.24 ± 0.036	0.797HisPhe: 0.797 ± 0.023	2.095HisGly: 2.095 ± 0.044	0.665HisHis: 0.665 ± 0.028	0.852HisIle: 0.852 ± 0.033	0.469HisLys: 0.469 ± 0.022	2.25HisLeu: 2.25 ± 0.048	0.472HisMet: 0.472 ± 0.018	0.387HisAsn: 0.387 ± 0.016	1.382HisPro: 1.382 ± 0.036	0.537HisGln: 0.537 ± 0.023	1.695HisArg: 1.695 ± 0.04	0.902HisSer: 0.902 ± 0.028	0.745HisThr: 0.745 ± 0.025	1.674HisVal: 1.674 ± 0.037	0.364HisTrp: 0.364 ± 0.017	0.552HisTyr: 0.552 ± 0.022	0.002HisXaa: 0.002 ± 0.001
Ile	6.734IleAla: 6.734 ± 0.084	0.551IleCys: 0.551 ± 0.024	3.484IleAsp: 3.484 ± 0.059	3.428IleGlu: 3.428 ± 0.06	1.591IlePhe: 1.591 ± 0.039	4.565IleGly: 4.565 ± 0.067	0.892IleHis: 0.892 ± 0.025	1.752IleIle: 1.752 ± 0.047	1.065IleLys: 1.065 ± 0.034	4.541IleLeu: 4.541 ± 0.072	0.883IleMet: 0.883 ± 0.031	1.077IleAsn: 1.077 ± 0.035	2.154IlePro: 2.154 ± 0.045	0.981IleGln: 0.981 ± 0.033	3.464IleArg: 3.464 ± 0.059	2.459IleSer: 2.459 ± 0.047	2.467IleThr: 2.467 ± 0.047	4.056IleVal: 4.056 ± 0.073	0.716IleTrp: 0.716 ± 0.026	1.008IleTyr: 1.008 ± 0.031	0.001IleXaa: 0.001 ± 0.001
Lys	3.4LysAla: 3.4 ± 0.071	0.14LysCys: 0.14 ± 0.01	1.382LysAsp: 1.382 ± 0.038	1.263LysGlu: 1.263 ± 0.041	0.702LysPhe: 0.702 ± 0.028	2.243LysGly: 2.243 ± 0.05	0.59LysHis: 0.59 ± 0.025	1.304LysIle: 1.304 ± 0.037	1.079LysLys: 1.079 ± 0.037	2.755LysLeu: 2.755 ± 0.053	0.7LysMet: 0.7 ± 0.026	0.672LysAsn: 0.672 ± 0.027	1.619LysPro: 1.619 ± 0.036	0.741LysGln: 0.741 ± 0.03	2.275LysArg: 2.275 ± 0.05	1.498LysSer: 1.498 ± 0.039	1.74LysThr: 1.74 ± 0.042	1.93LysVal: 1.93 ± 0.048	0.362LysTrp: 0.362 ± 0.021	0.486LysTyr: 0.486 ± 0.025	0.002LysXaa: 0.002 ± 0.001
Leu	13.189LeuAla: 13.189 ± 0.132	0.975LeuCys: 0.975 ± 0.029	6.427LeuAsp: 6.427 ± 0.095	5.508LeuGlu: 5.508 ± 0.065	3.321LeuPhe: 3.321 ± 0.066	8.182LeuGly: 8.182 ± 0.1	2.094LeuHis: 2.094 ± 0.049	4.778LeuIle: 4.778 ± 0.075	2.622LeuLys: 2.622 ± 0.055	9.168LeuLeu: 9.168 ± 0.138	2.493LeuMet: 2.493 ± 0.043	2.401LeuAsn: 2.401 ± 0.048	5.762LeuPro: 5.762 ± 0.071	2.445LeuGln: 2.445 ± 0.048	8.364LeuArg: 8.364 ± 0.093	6.19LeuSer: 6.19 ± 0.08	5.954LeuThr: 5.954 ± 0.082	6.956LeuVal: 6.956 ± 0.092	1.312LeuTrp: 1.312 ± 0.037	1.841LeuTyr: 1.841 ± 0.044	0.003LeuXaa: 0.003 ± 0.002
Met	3.392MetAla: 3.392 ± 0.06	0.161MetCys: 0.161 ± 0.012	1.304MetAsp: 1.304 ± 0.034	1.382MetGlu: 1.382 ± 0.037	0.702MetPhe: 0.702 ± 0.027	2.085MetGly: 2.085 ± 0.045	0.431MetHis: 0.431 ± 0.02	1.395MetIle: 1.395 ± 0.032	0.965MetLys: 0.965 ± 0.034	2.586MetLeu: 2.586 ± 0.045	0.702MetMet: 0.702 ± 0.029	0.787MetAsn: 0.787 ± 0.024	1.519MetPro: 1.519 ± 0.035	0.803MetGln: 0.803 ± 0.029	2.174MetArg: 2.174 ± 0.045	1.572MetSer: 1.572 ± 0.04	1.889MetThr: 1.889 ± 0.044	1.718MetVal: 1.718 ± 0.041	0.238MetTrp: 0.238 ± 0.019	0.289MetTyr: 0.289 ± 0.017	0.002MetXaa: 0.002 ± 0.001
Asn	3.014AsnAla: 3.014 ± 0.058	0.219AsnCys: 0.219 ± 0.014	1.257AsnAsp: 1.257 ± 0.036	1.086AsnGlu: 1.086 ± 0.036	0.854AsnPhe: 0.854 ± 0.026	2.104AsnGly: 2.104 ± 0.04	0.482AsnHis: 0.482 ± 0.022	1.171AsnIle: 1.171 ± 0.036	0.513AsnLys: 0.513 ± 0.023	2.315AsnLeu: 2.315 ± 0.046	0.55AsnMet: 0.55 ± 0.022	0.581AsnAsn: 0.581 ± 0.024	1.702AsnPro: 1.702 ± 0.036	0.645AsnGln: 0.645 ± 0.027	1.843AsnArg: 1.843 ± 0.044	0.955AsnSer: 0.955 ± 0.028	1.04AsnThr: 1.04 ± 0.035	1.721AsnVal: 1.721 ± 0.041	0.395AsnTrp: 0.395 ± 0.019	0.517AsnTyr: 0.517 ± 0.022	0.002AsnXaa: 0.002 ± 0.001
Pro	6.325ProAla: 6.325 ± 0.088	0.404ProCys: 0.404 ± 0.023	4.354ProAsp: 4.354 ± 0.076	4.661ProGlu: 4.661 ± 0.068	2.015ProPhe: 2.015 ± 0.038	4.556ProGly: 4.556 ± 0.063	1.075ProHis: 1.075 ± 0.031	2.156ProIle: 2.156 ± 0.045	1.613ProLys: 1.613 ± 0.043	4.726ProLeu: 4.726 ± 0.067	1.24ProMet: 1.24 ± 0.032	1.217ProAsn: 1.217 ± 0.035	2.917ProPro: 2.917 ± 0.067	1.621ProGln: 1.621 ± 0.045	3.535ProArg: 3.535 ± 0.064	2.547ProSer: 2.547 ± 0.05	2.399ProThr: 2.399 ± 0.049	4.314ProVal: 4.314 ± 0.071	0.775ProTrp: 0.775 ± 0.025	1.048ProTyr: 1.048 ± 0.033	0.001ProXaa: 0.001 ± 0.001
Gln	3.716GlnAla: 3.716 ± 0.056	0.176GlnCys: 0.176 ± 0.012	1.58GlnAsp: 1.58 ± 0.041	1.62GlnGlu: 1.62 ± 0.042	0.957GlnPhe: 0.957 ± 0.03	2.274GlnGly: 2.274 ± 0.049	0.573GlnHis: 0.573 ± 0.024	1.722GlnIle: 1.722 ± 0.044	0.852GlnLys: 0.852 ± 0.032	2.355GlnLeu: 2.355 ± 0.048	0.862GlnMet: 0.862 ± 0.031	0.713GlnAsn: 0.713 ± 0.028	1.532GlnPro: 1.532 ± 0.039	0.978GlnGln: 0.978 ± 0.034	2.21GlnArg: 2.21 ± 0.054	1.511GlnSer: 1.511 ± 0.036	1.572GlnThr: 1.572 ± 0.039	2.322GlnVal: 2.322 ± 0.056	0.363GlnTrp: 0.363 ± 0.019	0.481GlnTyr: 0.481 ± 0.023	0.0GlnXaa: 0.0 ± 0.0
Arg	9.584ArgAla: 9.584 ± 0.11	0.637ArgCys: 0.637 ± 0.028	5.331ArgAsp: 5.331 ± 0.08	4.679ArgGlu: 4.679 ± 0.071	2.927ArgPhe: 2.927 ± 0.053	5.78ArgGly: 5.78 ± 0.079	1.987ArgHis: 1.987 ± 0.04	4.45ArgIle: 4.45 ± 0.062	2.306ArgLys: 2.306 ± 0.055	8.773ArgLeu: 8.773 ± 0.102	2.181ArgMet: 2.181 ± 0.043	1.922ArgAsn: 1.922 ± 0.047	4.104ArgPro: 4.104 ± 0.068	2.478ArgGln: 2.478 ± 0.046	7.254ArgArg: 7.254 ± 0.111	3.756ArgSer: 3.756 ± 0.065	4.004ArgThr: 4.004 ± 0.062	5.43ArgVal: 5.43 ± 0.078	1.187ArgTrp: 1.187 ± 0.034	1.69ArgTyr: 1.69 ± 0.042	0.003ArgXaa: 0.003 ± 0.002
Ser	5.542SerAla: 5.542 ± 0.075	0.486SerCys: 0.486 ± 0.023	3.252SerAsp: 3.252 ± 0.056	2.846SerGlu: 2.846 ± 0.049	1.915SerPhe: 1.915 ± 0.039	5.012SerGly: 5.012 ± 0.083	1.036SerHis: 1.036 ± 0.032	2.102SerIle: 2.102 ± 0.042	1.369SerLys: 1.369 ± 0.039	4.569SerLeu: 4.569 ± 0.07	1.198SerMet: 1.198 ± 0.034	1.092SerAsn: 1.092 ± 0.033	2.459SerPro: 2.459 ± 0.052	1.419SerGln: 1.419 ± 0.041	3.637SerArg: 3.637 ± 0.055	2.376SerSer: 2.376 ± 0.05	2.292SerThr: 2.292 ± 0.049	3.548SerVal: 3.548 ± 0.065	0.767SerTrp: 0.767 ± 0.028	1.149SerTyr: 1.149 ± 0.032	0.0SerXaa: 0.0 ± 0.0
Thr	6.313ThrAla: 6.313 ± 0.076	0.519ThrCys: 0.519 ± 0.025	3.207ThrAsp: 3.207 ± 0.047	3.122ThrGlu: 3.122 ± 0.058	2.052ThrPhe: 2.052 ± 0.043	5.422ThrGly: 5.422 ± 0.077	1.123ThrHis: 1.123 ± 0.034	2.629ThrIle: 2.629 ± 0.057	1.253ThrLys: 1.253 ± 0.033	5.898ThrLeu: 5.898 ± 0.077	1.278ThrMet: 1.278 ± 0.031	1.243ThrAsn: 1.243 ± 0.039	3.441ThrPro: 3.441 ± 0.058	1.392ThrGln: 1.392 ± 0.035	4.055ThrArg: 4.055 ± 0.067	2.641ThrSer: 2.641 ± 0.051	2.87ThrThr: 2.87 ± 0.06	3.863ThrVal: 3.863 ± 0.061	0.728ThrTrp: 0.728 ± 0.029	1.105ThrTyr: 1.105 ± 0.032	0.0ThrXaa: 0.0 ± 0.0
Val	9.557ValAla: 9.557 ± 0.108	0.641ValCys: 0.641 ± 0.025	4.079ValAsp: 4.079 ± 0.071	4.772ValGlu: 4.772 ± 0.074	2.634ValPhe: 2.634 ± 0.055	5.463ValGly: 5.463 ± 0.081	1.355ValHis: 1.355 ± 0.038	3.752ValIle: 3.752 ± 0.074	1.852ValLys: 1.852 ± 0.045	7.429ValLeu: 7.429 ± 0.094	1.888ValMet: 1.888 ± 0.036	1.747ValAsn: 1.747 ± 0.041	3.899ValPro: 3.899 ± 0.06	1.915ValGln: 1.915 ± 0.043	5.046ValArg: 5.046 ± 0.063	3.937ValSer: 3.937 ± 0.069	4.797ValThr: 4.797 ± 0.066	5.653ValVal: 5.653 ± 0.09	1.053ValTrp: 1.053 ± 0.031	1.287ValTyr: 1.287 ± 0.032	0.005ValXaa: 0.005 ± 0.002
Trp	1.415TrpAla: 1.415 ± 0.037	0.141TrpCys: 0.141 ± 0.012	0.808TrpAsp: 0.808 ± 0.026	0.695TrpGlu: 0.695 ± 0.027	0.584TrpPhe: 0.584 ± 0.022	0.991TrpGly: 0.991 ± 0.038	0.413TrpHis: 0.413 ± 0.018	0.747TrpIle: 0.747 ± 0.028	0.484TrpLys: 0.484 ± 0.023	1.746TrpLeu: 1.746 ± 0.037	0.392TrpMet: 0.392 ± 0.019	0.431TrpAsn: 0.431 ± 0.018	0.778TrpPro: 0.778 ± 0.026	0.644TrpGln: 0.644 ± 0.025	1.508TrpArg: 1.508 ± 0.039	0.885TrpSer: 0.885 ± 0.032	0.89TrpThr: 0.89 ± 0.026	0.918TrpVal: 0.918 ± 0.029	0.298TrpTrp: 0.298 ± 0.015	0.243TrpTyr: 0.243 ± 0.014	0.001TrpXaa: 0.001 ± 0.001
Tyr	2.298TyrAla: 2.298 ± 0.046	0.247TyrCys: 0.247 ± 0.015	1.518TyrAsp: 1.518 ± 0.044	1.193TyrGlu: 1.193 ± 0.037	0.767TyrPhe: 0.767 ± 0.026	1.923TyrGly: 1.923 ± 0.044	0.454TyrHis: 0.454 ± 0.022	0.75TyrIle: 0.75 ± 0.027	0.451TyrLys: 0.451 ± 0.019	2.012TyrLeu: 2.012 ± 0.054	0.418TyrMet: 0.418 ± 0.023	0.491TyrAsn: 0.491 ± 0.02	0.971TyrPro: 0.971 ± 0.029	0.516TyrGln: 0.516 ± 0.022	1.594TyrArg: 1.594 ± 0.043	0.949TyrSer: 0.949 ± 0.035	0.919TyrThr: 0.919 ± 0.031	1.43TyrVal: 1.43 ± 0.038	0.341TyrTrp: 0.341 ± 0.018	0.488TyrTyr: 0.488 ± 0.024	0.001TyrXaa: 0.001 ± 0.001
Xaa	0.002XaaAla: 0.002 ± 0.001	0.0XaaCys: 0.0 ± 0.0	0.001XaaAsp: 0.001 ± 0.001	0.0XaaGlu: 0.0 ± 0.0	0.002XaaPhe: 0.002 ± 0.001	0.0XaaGly: 0.0 ± 0.0	0.002XaaHis: 0.002 ± 0.001	0.002XaaIle: 0.002 ± 0.001	0.0XaaLys: 0.0 ± 0.0	0.003XaaLeu: 0.003 ± 0.002	0.001XaaMet: 0.001 ± 0.001	0.0XaaAsn: 0.0 ± 0.0	0.001XaaPro: 0.001 ± 0.001	0.002XaaGln: 0.002 ± 0.001	0.004XaaArg: 0.004 ± 0.002	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.003XaaVal: 0.003 ± 0.002	0.0XaaTrp: 0.0 ± 0.0	0.001XaaTyr: 0.001 ± 0.001	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3710 proteins (1077800 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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