Amino acid dipepetide frequency for Blackcurrant leafroll-associated virus 1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.669AlaAla: 4.669 ± 1.233
0.934AlaCys: 0.934 ± 0.502
2.054AlaAsp: 2.054 ± 0.575
2.988AlaGlu: 2.988 ± 0.435
3.922AlaPhe: 3.922 ± 0.959
4.855AlaGly: 4.855 ± 1.007
0.747AlaHis: 0.747 ± 0.309
2.988AlaIle: 2.988 ± 0.69
2.988AlaLys: 2.988 ± 0.503
5.789AlaLeu: 5.789 ± 1.102
0.747AlaMet: 0.747 ± 0.402
2.241AlaAsn: 2.241 ± 0.549
3.548AlaPro: 3.548 ± 0.937
1.681AlaGln: 1.681 ± 0.417
2.988AlaArg: 2.988 ± 0.808
5.415AlaSer: 5.415 ± 1.45
2.241AlaThr: 2.241 ± 1.009
3.361AlaVal: 3.361 ± 0.779
0.373AlaTrp: 0.373 ± 0.327
2.241AlaTyr: 2.241 ± 0.86
0.0AlaXaa: 0.0 ± 0.0
Cys
1.494CysAla: 1.494 ± 0.773
1.12CysCys: 1.12 ± 0.461
2.428CysAsp: 2.428 ± 0.526
2.241CysGlu: 2.241 ± 0.751
2.241CysPhe: 2.241 ± 0.922
1.494CysGly: 1.494 ± 0.568
0.373CysHis: 0.373 ± 0.258
0.934CysIle: 0.934 ± 1.024
1.494CysLys: 1.494 ± 0.403
3.548CysLeu: 3.548 ± 0.742
0.56CysMet: 0.56 ± 0.287
0.373CysAsn: 0.373 ± 0.229
0.934CysPro: 0.934 ± 0.572
0.373CysGln: 0.373 ± 0.232
0.934CysArg: 0.934 ± 0.333
3.175CysSer: 3.175 ± 0.845
1.494CysThr: 1.494 ± 0.503
1.12CysVal: 1.12 ± 0.391
0.187CysTrp: 0.187 ± 0.29
0.56CysTyr: 0.56 ± 0.343
0.0CysXaa: 0.0 ± 0.0
Asp
4.669AspAla: 4.669 ± 0.819
2.054AspCys: 2.054 ± 1.121
5.229AspAsp: 5.229 ± 1.005
2.801AspGlu: 2.801 ± 0.555
3.361AspPhe: 3.361 ± 0.431
2.241AspGly: 2.241 ± 0.491
0.56AspHis: 0.56 ± 0.268
5.415AspIle: 5.415 ± 1.163
3.922AspLys: 3.922 ± 1.029
6.909AspLeu: 6.909 ± 0.665
1.307AspMet: 1.307 ± 0.588
1.681AspAsn: 1.681 ± 0.42
1.681AspPro: 1.681 ± 0.716
1.307AspGln: 1.307 ± 0.67
3.175AspArg: 3.175 ± 0.758
5.976AspSer: 5.976 ± 1.209
1.867AspThr: 1.867 ± 0.855
4.855AspVal: 4.855 ± 0.798
0.0AspTrp: 0.0 ± 0.0
3.548AspTyr: 3.548 ± 1.367
0.0AspXaa: 0.0 ± 0.0
Glu
3.175GluAla: 3.175 ± 0.565
2.428GluCys: 2.428 ± 0.729
4.669GluAsp: 4.669 ± 1.273
2.428GluGlu: 2.428 ± 0.779
3.175GluPhe: 3.175 ± 0.876
2.988GluGly: 2.988 ± 0.764
0.934GluHis: 0.934 ± 0.339
2.614GluIle: 2.614 ± 1.01
2.801GluLys: 2.801 ± 1.573
5.415GluLeu: 5.415 ± 1.191
1.494GluMet: 1.494 ± 0.559
1.494GluAsn: 1.494 ± 0.636
0.747GluPro: 0.747 ± 0.278
0.934GluGln: 0.934 ± 0.351
3.548GluArg: 3.548 ± 0.737
4.855GluSer: 4.855 ± 0.768
2.241GluThr: 2.241 ± 0.808
5.042GluVal: 5.042 ± 0.888
0.56GluTrp: 0.56 ± 0.268
2.054GluTyr: 2.054 ± 1.484
0.0GluXaa: 0.0 ± 0.0
Phe
2.614PheAla: 2.614 ± 1.022
1.494PheCys: 1.494 ± 0.56
4.482PheAsp: 4.482 ± 1.019
4.295PheGlu: 4.295 ± 1.506
2.801PhePhe: 2.801 ± 1.066
3.735PheGly: 3.735 ± 0.823
1.12PheHis: 1.12 ± 0.312
3.735PheIle: 3.735 ± 0.502
4.855PheLys: 4.855 ± 1.192
5.229PheLeu: 5.229 ± 0.917
0.747PheMet: 0.747 ± 0.233
2.988PheAsn: 2.988 ± 0.644
1.307PhePro: 1.307 ± 0.39
1.494PheGln: 1.494 ± 0.379
3.548PheArg: 3.548 ± 1.073
6.536PheSer: 6.536 ± 1.786
2.428PheThr: 2.428 ± 0.846
2.988PheVal: 2.988 ± 0.845
0.187PheTrp: 0.187 ± 0.26
1.681PheTyr: 1.681 ± 0.612
0.0PheXaa: 0.0 ± 0.0
Gly
3.922GlyAla: 3.922 ± 0.882
2.241GlyCys: 2.241 ± 0.481
5.042GlyAsp: 5.042 ± 0.618
3.175GlyGlu: 3.175 ± 0.424
3.922GlyPhe: 3.922 ± 1.501
4.669GlyGly: 4.669 ± 1.27
0.747GlyHis: 0.747 ± 0.326
2.241GlyIle: 2.241 ± 0.342
2.428GlyLys: 2.428 ± 1.091
4.669GlyLeu: 4.669 ± 0.842
0.373GlyMet: 0.373 ± 0.229
2.428GlyAsn: 2.428 ± 0.473
0.373GlyPro: 0.373 ± 0.362
1.12GlyGln: 1.12 ± 0.64
2.428GlyArg: 2.428 ± 0.892
4.855GlySer: 4.855 ± 1.582
1.12GlyThr: 1.12 ± 0.511
7.096GlyVal: 7.096 ± 0.66
0.187GlyTrp: 0.187 ± 0.278
2.801GlyTyr: 2.801 ± 0.967
0.0GlyXaa: 0.0 ± 0.0
His
0.747HisAla: 0.747 ± 0.481
1.12HisCys: 1.12 ± 0.353
0.0HisAsp: 0.0 ± 0.0
1.867HisGlu: 1.867 ± 0.521
1.307HisPhe: 1.307 ± 0.427
0.373HisGly: 0.373 ± 0.255
0.747HisHis: 0.747 ± 0.458
1.494HisIle: 1.494 ± 0.766
0.373HisLys: 0.373 ± 0.232
1.494HisLeu: 1.494 ± 0.442
0.373HisMet: 0.373 ± 0.255
0.373HisAsn: 0.373 ± 0.258
0.934HisPro: 0.934 ± 0.684
0.373HisGln: 0.373 ± 0.252
1.494HisArg: 1.494 ± 0.56
2.054HisSer: 2.054 ± 0.81
1.494HisThr: 1.494 ± 0.916
0.747HisVal: 0.747 ± 0.344
0.0HisTrp: 0.0 ± 0.0
1.12HisTyr: 1.12 ± 0.391
0.0HisXaa: 0.0 ± 0.0
Ile
2.801IleAla: 2.801 ± 0.906
0.747IleCys: 0.747 ± 0.353
3.175IleAsp: 3.175 ± 0.573
4.295IleGlu: 4.295 ± 0.812
2.428IlePhe: 2.428 ± 0.414
2.428IleGly: 2.428 ± 0.485
1.494IleHis: 1.494 ± 0.298
2.988IleIle: 2.988 ± 0.592
5.229IleLys: 5.229 ± 0.79
3.922IleLeu: 3.922 ± 1.24
0.747IleMet: 0.747 ± 0.796
3.548IleAsn: 3.548 ± 0.955
2.428IlePro: 2.428 ± 1.016
0.373IleGln: 0.373 ± 0.382
2.054IleArg: 2.054 ± 0.537
6.723IleSer: 6.723 ± 1.34
4.295IleThr: 4.295 ± 0.968
4.108IleVal: 4.108 ± 0.856
0.373IleTrp: 0.373 ± 0.375
2.241IleTyr: 2.241 ± 0.771
0.0IleXaa: 0.0 ± 0.0
Lys
3.922LysAla: 3.922 ± 1.258
1.867LysCys: 1.867 ± 0.611
1.681LysAsp: 1.681 ± 0.631
3.175LysGlu: 3.175 ± 1.467
5.042LysPhe: 5.042 ± 1.305
3.735LysGly: 3.735 ± 1.136
1.307LysHis: 1.307 ± 0.613
3.735LysIle: 3.735 ± 0.892
3.548LysLys: 3.548 ± 1.011
6.909LysLeu: 6.909 ± 1.349
0.747LysMet: 0.747 ± 0.276
2.801LysAsn: 2.801 ± 0.681
3.175LysPro: 3.175 ± 0.721
1.681LysGln: 1.681 ± 0.792
3.361LysArg: 3.361 ± 0.586
4.295LysSer: 4.295 ± 1.792
3.175LysThr: 3.175 ± 0.891
5.976LysVal: 5.976 ± 1.149
0.747LysTrp: 0.747 ± 0.465
2.241LysTyr: 2.241 ± 0.714
0.0LysXaa: 0.0 ± 0.0
Leu
4.855LeuAla: 4.855 ± 0.771
2.614LeuCys: 2.614 ± 0.707
5.789LeuAsp: 5.789 ± 1.466
4.108LeuGlu: 4.108 ± 1.369
4.855LeuPhe: 4.855 ± 0.784
6.349LeuGly: 6.349 ± 1.091
1.681LeuHis: 1.681 ± 0.481
6.909LeuIle: 6.909 ± 0.694
7.843LeuLys: 7.843 ± 1.335
8.403LeuLeu: 8.403 ± 1.096
1.494LeuMet: 1.494 ± 0.238
4.108LeuAsn: 4.108 ± 1.288
3.548LeuPro: 3.548 ± 0.515
2.614LeuGln: 2.614 ± 0.74
6.723LeuArg: 6.723 ± 0.951
10.831LeuSer: 10.831 ± 1.896
4.855LeuThr: 4.855 ± 1.167
7.656LeuVal: 7.656 ± 1.116
0.187LeuTrp: 0.187 ± 0.37
1.867LeuTyr: 1.867 ± 0.666
0.0LeuXaa: 0.0 ± 0.0
Met
1.681MetAla: 1.681 ± 0.727
0.187MetCys: 0.187 ± 0.335
0.373MetAsp: 0.373 ± 0.259
0.56MetGlu: 0.56 ± 0.322
0.187MetPhe: 0.187 ± 0.251
0.934MetGly: 0.934 ± 0.367
0.747MetHis: 0.747 ± 0.355
1.681MetIle: 1.681 ± 0.75
1.494MetLys: 1.494 ± 0.601
1.307MetLeu: 1.307 ± 0.355
0.373MetMet: 0.373 ± 0.362
1.12MetAsn: 1.12 ± 0.462
0.373MetPro: 0.373 ± 0.452
0.56MetGln: 0.56 ± 0.215
1.681MetArg: 1.681 ± 0.488
1.681MetSer: 1.681 ± 0.529
0.56MetThr: 0.56 ± 0.328
1.12MetVal: 1.12 ± 0.64
0.0MetTrp: 0.0 ± 0.0
0.934MetTyr: 0.934 ± 0.439
0.0MetXaa: 0.0 ± 0.0
Asn
1.681AsnAla: 1.681 ± 0.477
1.12AsnCys: 1.12 ± 0.692
2.801AsnAsp: 2.801 ± 0.514
2.801AsnGlu: 2.801 ± 0.442
1.494AsnPhe: 1.494 ± 1.002
1.867AsnGly: 1.867 ± 0.877
1.12AsnHis: 1.12 ± 0.429
1.867AsnIle: 1.867 ± 0.976
1.681AsnLys: 1.681 ± 0.723
4.482AsnLeu: 4.482 ± 0.87
1.307AsnMet: 1.307 ± 0.565
1.12AsnAsn: 1.12 ± 0.37
2.614AsnPro: 2.614 ± 1.136
0.747AsnGln: 0.747 ± 0.616
2.614AsnArg: 2.614 ± 1.089
5.229AsnSer: 5.229 ± 1.778
2.801AsnThr: 2.801 ± 1.171
3.922AsnVal: 3.922 ± 1.029
0.187AsnTrp: 0.187 ± 0.114
0.934AsnTyr: 0.934 ± 0.303
0.0AsnXaa: 0.0 ± 0.0
Pro
1.681ProAla: 1.681 ± 0.304
0.373ProCys: 0.373 ± 0.232
2.428ProAsp: 2.428 ± 0.717
1.867ProGlu: 1.867 ± 0.832
3.175ProPhe: 3.175 ± 0.864
1.867ProGly: 1.867 ± 0.604
1.12ProHis: 1.12 ± 0.31
2.428ProIle: 2.428 ± 0.549
3.175ProLys: 3.175 ± 1.1
2.801ProLeu: 2.801 ± 0.771
0.373ProMet: 0.373 ± 0.374
0.934ProAsn: 0.934 ± 0.348
1.494ProPro: 1.494 ± 0.567
0.934ProGln: 0.934 ± 0.572
2.614ProArg: 2.614 ± 0.496
4.108ProSer: 4.108 ± 0.931
2.241ProThr: 2.241 ± 0.524
1.867ProVal: 1.867 ± 0.692
0.187ProTrp: 0.187 ± 0.114
1.681ProTyr: 1.681 ± 0.951
0.0ProXaa: 0.0 ± 0.0
Gln
1.494GlnAla: 1.494 ± 0.535
0.747GlnCys: 0.747 ± 0.328
1.12GlnAsp: 1.12 ± 0.218
2.241GlnGlu: 2.241 ± 0.477
0.56GlnPhe: 0.56 ± 0.343
0.56GlnGly: 0.56 ± 0.27
0.747GlnHis: 0.747 ± 0.535
0.934GlnIle: 0.934 ± 0.324
1.12GlnLys: 1.12 ± 0.749
2.614GlnLeu: 2.614 ± 1.148
0.747GlnMet: 0.747 ± 0.458
1.494GlnAsn: 1.494 ± 0.466
1.12GlnPro: 1.12 ± 0.37
0.747GlnGln: 0.747 ± 0.328
1.867GlnArg: 1.867 ± 0.44
1.681GlnSer: 1.681 ± 0.505
1.12GlnThr: 1.12 ± 0.541
2.054GlnVal: 2.054 ± 0.736
0.0GlnTrp: 0.0 ± 0.0
0.187GlnTyr: 0.187 ± 0.251
0.0GlnXaa: 0.0 ± 0.0
Arg
3.175ArgAla: 3.175 ± 0.854
2.988ArgCys: 2.988 ± 0.98
3.735ArgAsp: 3.735 ± 0.456
2.428ArgGlu: 2.428 ± 0.771
3.361ArgPhe: 3.361 ± 0.931
3.361ArgGly: 3.361 ± 1.021
0.747ArgHis: 0.747 ± 0.458
3.548ArgIle: 3.548 ± 1.032
3.922ArgLys: 3.922 ± 0.88
4.482ArgLeu: 4.482 ± 0.821
1.494ArgMet: 1.494 ± 0.462
2.054ArgAsn: 2.054 ± 0.517
2.801ArgPro: 2.801 ± 1.123
0.934ArgGln: 0.934 ± 0.572
4.482ArgArg: 4.482 ± 0.791
6.723ArgSer: 6.723 ± 1.325
2.801ArgThr: 2.801 ± 0.839
3.922ArgVal: 3.922 ± 0.842
0.747ArgTrp: 0.747 ± 0.51
1.867ArgTyr: 1.867 ± 0.591
0.0ArgXaa: 0.0 ± 0.0
Ser
4.669SerAla: 4.669 ± 1.249
2.428SerCys: 2.428 ± 0.855
6.723SerAsp: 6.723 ± 0.509
4.855SerGlu: 4.855 ± 0.778
4.855SerPhe: 4.855 ± 1.336
5.229SerGly: 5.229 ± 0.537
1.12SerHis: 1.12 ± 0.411
4.855SerIle: 4.855 ± 0.973
8.03SerLys: 8.03 ± 0.77
11.951SerLeu: 11.951 ± 1.665
1.494SerMet: 1.494 ± 0.394
3.175SerAsn: 3.175 ± 0.951
4.295SerPro: 4.295 ± 1.509
3.735SerGln: 3.735 ± 1.349
6.909SerArg: 6.909 ± 1.972
10.458SerSer: 10.458 ± 3.398
5.229SerThr: 5.229 ± 1.477
6.349SerVal: 6.349 ± 1.03
0.934SerTrp: 0.934 ± 0.521
2.614SerTyr: 2.614 ± 0.883
0.0SerXaa: 0.0 ± 0.0
Thr
2.054ThrAla: 2.054 ± 0.579
0.934ThrCys: 0.934 ± 0.418
2.988ThrAsp: 2.988 ± 0.58
1.867ThrGlu: 1.867 ± 0.81
4.108ThrPhe: 4.108 ± 1.152
2.801ThrGly: 2.801 ± 1.685
0.747ThrHis: 0.747 ± 0.458
2.428ThrIle: 2.428 ± 0.341
1.494ThrLys: 1.494 ± 0.56
5.789ThrLeu: 5.789 ± 1.186
0.373ThrMet: 0.373 ± 0.229
2.988ThrAsn: 2.988 ± 0.956
2.801ThrPro: 2.801 ± 0.75
1.12ThrGln: 1.12 ± 0.467
1.867ThrArg: 1.867 ± 0.573
5.976ThrSer: 5.976 ± 1.795
2.988ThrThr: 2.988 ± 1.502
4.482ThrVal: 4.482 ± 1.324
0.747ThrTrp: 0.747 ± 0.555
1.307ThrTyr: 1.307 ± 0.593
0.0ThrXaa: 0.0 ± 0.0
Val
4.855ValAla: 4.855 ± 0.999
1.307ValCys: 1.307 ± 0.602
5.042ValAsp: 5.042 ± 1.234
4.295ValGlu: 4.295 ± 1.155
5.042ValPhe: 5.042 ± 0.902
3.922ValGly: 3.922 ± 0.811
1.681ValHis: 1.681 ± 0.596
3.735ValIle: 3.735 ± 0.581
5.229ValLys: 5.229 ± 1.229
5.602ValLeu: 5.602 ± 1.533
1.867ValMet: 1.867 ± 0.616
5.789ValAsn: 5.789 ± 1.327
2.428ValPro: 2.428 ± 0.996
1.307ValGln: 1.307 ± 0.459
5.415ValArg: 5.415 ± 1.127
6.162ValSer: 6.162 ± 1.672
3.922ValThr: 3.922 ± 0.65
8.217ValVal: 8.217 ± 1.743
0.373ValTrp: 0.373 ± 0.229
3.175ValTyr: 3.175 ± 0.801
0.0ValXaa: 0.0 ± 0.0
Trp
0.56TrpAla: 0.56 ± 0.784
0.0TrpCys: 0.0 ± 0.0
0.373TrpAsp: 0.373 ± 0.229
0.373TrpGlu: 0.373 ± 0.388
0.187TrpPhe: 0.187 ± 0.278
0.747TrpGly: 0.747 ± 0.663
0.0TrpHis: 0.0 ± 0.0
0.373TrpIle: 0.373 ± 0.255
0.187TrpLys: 0.187 ± 0.29
1.12TrpLeu: 1.12 ± 0.513
0.373TrpMet: 0.373 ± 0.555
0.747TrpAsn: 0.747 ± 0.292
0.0TrpPro: 0.0 ± 0.0
0.0TrpGln: 0.0 ± 0.0
0.373TrpArg: 0.373 ± 0.229
0.187TrpSer: 0.187 ± 0.335
0.0TrpThr: 0.0 ± 0.0
0.747TrpVal: 0.747 ± 0.334
0.0TrpTrp: 0.0 ± 0.0
0.0TrpTyr: 0.0 ± 0.0
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.054TyrAla: 2.054 ± 0.39
0.373TyrCys: 0.373 ± 0.229
2.428TyrAsp: 2.428 ± 0.81
1.12TyrGlu: 1.12 ± 0.402
2.241TyrPhe: 2.241 ± 0.581
1.681TyrGly: 1.681 ± 0.868
0.747TyrHis: 0.747 ± 0.42
1.494TyrIle: 1.494 ± 0.427
1.307TyrLys: 1.307 ± 0.57
4.855TyrLeu: 4.855 ± 0.886
0.373TyrMet: 0.373 ± 0.327
0.934TyrAsn: 0.934 ± 0.428
0.747TyrPro: 0.747 ± 0.559
1.12TyrGln: 1.12 ± 0.455
1.494TyrArg: 1.494 ± 0.613
2.988TyrSer: 2.988 ± 0.915
2.988TyrThr: 2.988 ± 0.99
3.735TyrVal: 3.735 ± 1.337
0.373TyrTrp: 0.373 ± 0.252
2.054TyrTyr: 2.054 ± 0.771
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 10 proteins (5356 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski