Amino acid dipepetide frequency for Cronobacter phage vB_CsaP_GAP52

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
8.095AlaAla: 8.095 ± 1.088
0.587AlaCys: 0.587 ± 0.145
3.817AlaAsp: 3.817 ± 0.456
5.369AlaGlu: 5.369 ± 0.531
2.642AlaPhe: 2.642 ± 0.346
6.711AlaGly: 6.711 ± 0.795
1.552AlaHis: 1.552 ± 0.27
4.236AlaIle: 4.236 ± 0.462
5.578AlaLys: 5.578 ± 0.669
7.298AlaLeu: 7.298 ± 0.802
2.6AlaMet: 2.6 ± 0.315
4.32AlaAsn: 4.32 ± 0.421
3.859AlaPro: 3.859 ± 0.637
3.901AlaGln: 3.901 ± 0.659
4.74AlaArg: 4.74 ± 0.503
4.823AlaSer: 4.823 ± 0.703
4.74AlaThr: 4.74 ± 0.511
5.201AlaVal: 5.201 ± 0.455
1.049AlaTrp: 1.049 ± 0.182
2.768AlaTyr: 2.768 ± 0.383
0.0AlaXaa: 0.0 ± 0.0
Cys
0.881CysAla: 0.881 ± 0.22
0.252CysCys: 0.252 ± 0.11
0.965CysAsp: 0.965 ± 0.167
0.587CysGlu: 0.587 ± 0.19
0.503CysPhe: 0.503 ± 0.154
0.839CysGly: 0.839 ± 0.237
0.294CysHis: 0.294 ± 0.121
0.629CysIle: 0.629 ± 0.161
0.503CysLys: 0.503 ± 0.159
0.839CysLeu: 0.839 ± 0.183
0.21CysMet: 0.21 ± 0.101
0.503CysAsn: 0.503 ± 0.15
0.713CysPro: 0.713 ± 0.175
0.21CysGln: 0.21 ± 0.094
0.755CysArg: 0.755 ± 0.189
0.797CysSer: 0.797 ± 0.252
0.503CysThr: 0.503 ± 0.129
0.629CysVal: 0.629 ± 0.162
0.084CysTrp: 0.084 ± 0.054
0.419CysTyr: 0.419 ± 0.122
0.0CysXaa: 0.0 ± 0.0
Asp
4.991AspAla: 4.991 ± 0.521
0.713AspCys: 0.713 ± 0.173
3.985AspAsp: 3.985 ± 0.409
4.74AspGlu: 4.74 ± 0.524
2.642AspPhe: 2.642 ± 0.383
5.453AspGly: 5.453 ± 0.587
0.881AspHis: 0.881 ± 0.213
3.943AspIle: 3.943 ± 0.48
3.943AspLys: 3.943 ± 0.445
4.362AspLeu: 4.362 ± 0.383
2.684AspMet: 2.684 ± 0.415
3.313AspAsn: 3.313 ± 0.381
2.936AspPro: 2.936 ± 0.285
1.552AspGln: 1.552 ± 0.288
2.055AspArg: 2.055 ± 0.282
3.943AspSer: 3.943 ± 0.36
3.523AspThr: 3.523 ± 0.388
3.817AspVal: 3.817 ± 0.405
1.426AspTrp: 1.426 ± 0.283
2.349AspTyr: 2.349 ± 0.349
0.0AspXaa: 0.0 ± 0.0
Glu
6.963GluAla: 6.963 ± 0.952
0.881GluCys: 0.881 ± 0.169
3.859GluAsp: 3.859 ± 0.504
5.033GluGlu: 5.033 ± 0.65
2.81GluPhe: 2.81 ± 0.326
4.194GluGly: 4.194 ± 0.394
1.594GluHis: 1.594 ± 0.265
3.943GluIle: 3.943 ± 0.437
3.733GluLys: 3.733 ± 0.441
5.83GluLeu: 5.83 ± 0.558
2.391GluMet: 2.391 ± 0.337
3.062GluAsn: 3.062 ± 0.413
1.678GluPro: 1.678 ± 0.259
3.188GluGln: 3.188 ± 0.406
3.565GluArg: 3.565 ± 0.425
4.278GluSer: 4.278 ± 0.561
3.649GluThr: 3.649 ± 0.335
4.991GluVal: 4.991 ± 0.472
1.258GluTrp: 1.258 ± 0.219
2.559GluTyr: 2.559 ± 0.339
0.0GluXaa: 0.0 ± 0.0
Phe
2.475PheAla: 2.475 ± 0.396
0.336PheCys: 0.336 ± 0.11
3.523PheAsp: 3.523 ± 0.353
2.223PheGlu: 2.223 ± 0.362
1.762PhePhe: 1.762 ± 0.378
3.02PheGly: 3.02 ± 0.385
1.049PheHis: 1.049 ± 0.174
1.762PheIle: 1.762 ± 0.26
2.307PheLys: 2.307 ± 0.332
2.265PheLeu: 2.265 ± 0.379
1.216PheMet: 1.216 ± 0.221
1.929PheAsn: 1.929 ± 0.27
1.091PhePro: 1.091 ± 0.239
1.342PheGln: 1.342 ± 0.226
1.845PheArg: 1.845 ± 0.263
2.81PheSer: 2.81 ± 0.345
2.391PheThr: 2.391 ± 0.346
2.852PheVal: 2.852 ± 0.358
0.629PheTrp: 0.629 ± 0.201
1.384PheTyr: 1.384 ± 0.212
0.0PheXaa: 0.0 ± 0.0
Gly
6.249GlyAla: 6.249 ± 0.803
1.342GlyCys: 1.342 ± 0.261
4.194GlyAsp: 4.194 ± 0.489
4.823GlyGlu: 4.823 ± 0.377
2.642GlyPhe: 2.642 ± 0.332
5.453GlyGly: 5.453 ± 0.786
1.804GlyHis: 1.804 ± 0.3
3.901GlyIle: 3.901 ± 0.361
5.83GlyLys: 5.83 ± 0.479
5.117GlyLeu: 5.117 ± 0.421
2.433GlyMet: 2.433 ± 0.334
3.607GlyAsn: 3.607 ± 0.412
0.671GlyPro: 0.671 ± 0.198
3.02GlyGln: 3.02 ± 0.333
3.23GlyArg: 3.23 ± 0.33
4.068GlySer: 4.068 ± 0.405
3.859GlyThr: 3.859 ± 0.401
5.956GlyVal: 5.956 ± 0.547
1.216GlyTrp: 1.216 ± 0.233
3.565GlyTyr: 3.565 ± 0.354
0.0GlyXaa: 0.0 ± 0.0
His
1.216HisAla: 1.216 ± 0.208
0.168HisCys: 0.168 ± 0.073
1.3HisAsp: 1.3 ± 0.248
1.3HisGlu: 1.3 ± 0.267
0.965HisPhe: 0.965 ± 0.194
1.804HisGly: 1.804 ± 0.261
0.294HisHis: 0.294 ± 0.095
1.552HisIle: 1.552 ± 0.245
1.3HisLys: 1.3 ± 0.25
1.384HisLeu: 1.384 ± 0.257
0.587HisMet: 0.587 ± 0.175
1.049HisAsn: 1.049 ± 0.226
0.839HisPro: 0.839 ± 0.202
0.503HisGln: 0.503 ± 0.128
1.049HisArg: 1.049 ± 0.249
1.216HisSer: 1.216 ± 0.203
0.965HisThr: 0.965 ± 0.186
1.174HisVal: 1.174 ± 0.218
0.461HisTrp: 0.461 ± 0.134
1.091HisTyr: 1.091 ± 0.226
0.0HisXaa: 0.0 ± 0.0
Ile
4.194IleAla: 4.194 ± 0.481
0.461IleCys: 0.461 ± 0.143
4.027IleAsp: 4.027 ± 0.506
3.355IleGlu: 3.355 ± 0.356
1.636IlePhe: 1.636 ± 0.293
4.068IleGly: 4.068 ± 0.389
1.3IleHis: 1.3 ± 0.252
2.642IleIle: 2.642 ± 0.361
4.068IleLys: 4.068 ± 0.42
3.439IleLeu: 3.439 ± 0.376
1.342IleMet: 1.342 ± 0.207
3.397IleAsn: 3.397 ± 0.411
2.81IlePro: 2.81 ± 0.375
2.055IleGln: 2.055 ± 0.287
2.391IleArg: 2.391 ± 0.323
2.768IleSer: 2.768 ± 0.411
3.23IleThr: 3.23 ± 0.367
3.691IleVal: 3.691 ± 0.404
0.797IleTrp: 0.797 ± 0.187
1.929IleTyr: 1.929 ± 0.275
0.0IleXaa: 0.0 ± 0.0
Lys
5.788LysAla: 5.788 ± 0.62
0.461LysCys: 0.461 ± 0.155
4.404LysAsp: 4.404 ± 0.456
5.662LysGlu: 5.662 ± 0.568
1.971LysPhe: 1.971 ± 0.275
4.362LysGly: 4.362 ± 0.434
1.552LysHis: 1.552 ± 0.284
3.272LysIle: 3.272 ± 0.387
4.068LysLys: 4.068 ± 0.593
4.488LysLeu: 4.488 ± 0.49
2.433LysMet: 2.433 ± 0.337
2.684LysAsn: 2.684 ± 0.379
3.188LysPro: 3.188 ± 0.404
2.6LysGln: 2.6 ± 0.364
3.901LysArg: 3.901 ± 0.476
3.397LysSer: 3.397 ± 0.469
3.439LysThr: 3.439 ± 0.424
4.278LysVal: 4.278 ± 0.498
1.091LysTrp: 1.091 ± 0.224
2.517LysTyr: 2.517 ± 0.315
0.0LysXaa: 0.0 ± 0.0
Leu
5.788LeuAla: 5.788 ± 0.55
1.091LeuCys: 1.091 ± 0.248
4.32LeuAsp: 4.32 ± 0.459
4.74LeuGlu: 4.74 ± 0.42
2.433LeuPhe: 2.433 ± 0.319
4.865LeuGly: 4.865 ± 0.467
0.881LeuHis: 0.881 ± 0.185
3.985LeuIle: 3.985 ± 0.513
5.117LeuLys: 5.117 ± 0.45
4.446LeuLeu: 4.446 ± 0.507
2.6LeuMet: 2.6 ± 0.339
4.152LeuAsn: 4.152 ± 0.438
3.062LeuPro: 3.062 ± 0.331
2.349LeuGln: 2.349 ± 0.351
3.691LeuArg: 3.691 ± 0.439
4.907LeuSer: 4.907 ± 0.44
4.614LeuThr: 4.614 ± 0.394
4.698LeuVal: 4.698 ± 0.537
0.839LeuTrp: 0.839 ± 0.209
2.559LeuTyr: 2.559 ± 0.303
0.0LeuXaa: 0.0 ± 0.0
Met
3.313MetAla: 3.313 ± 0.316
0.294MetCys: 0.294 ± 0.093
1.51MetAsp: 1.51 ± 0.252
2.181MetGlu: 2.181 ± 0.321
1.3MetPhe: 1.3 ± 0.222
2.433MetGly: 2.433 ± 0.332
0.336MetHis: 0.336 ± 0.113
1.426MetIle: 1.426 ± 0.223
2.517MetLys: 2.517 ± 0.358
2.894MetLeu: 2.894 ± 0.367
1.049MetMet: 1.049 ± 0.256
1.216MetAsn: 1.216 ± 0.206
1.384MetPro: 1.384 ± 0.192
1.72MetGln: 1.72 ± 0.364
1.887MetArg: 1.887 ± 0.268
2.181MetSer: 2.181 ± 0.346
1.258MetThr: 1.258 ± 0.196
1.678MetVal: 1.678 ± 0.232
0.503MetTrp: 0.503 ± 0.161
0.923MetTyr: 0.923 ± 0.232
0.0MetXaa: 0.0 ± 0.0
Asn
3.775AsnAla: 3.775 ± 0.452
0.545AsnCys: 0.545 ± 0.145
3.062AsnAsp: 3.062 ± 0.373
3.02AsnGlu: 3.02 ± 0.334
1.72AsnPhe: 1.72 ± 0.217
3.859AsnGly: 3.859 ± 0.481
1.174AsnHis: 1.174 ± 0.25
2.852AsnIle: 2.852 ± 0.299
2.559AsnLys: 2.559 ± 0.304
4.068AsnLeu: 4.068 ± 0.359
1.552AsnMet: 1.552 ± 0.273
2.894AsnAsn: 2.894 ± 0.361
2.559AsnPro: 2.559 ± 0.272
2.433AsnGln: 2.433 ± 0.56
2.81AsnArg: 2.81 ± 0.315
3.062AsnSer: 3.062 ± 0.391
2.936AsnThr: 2.936 ± 0.325
3.565AsnVal: 3.565 ± 0.404
1.091AsnTrp: 1.091 ± 0.274
2.223AsnTyr: 2.223 ± 0.296
0.0AsnXaa: 0.0 ± 0.0
Pro
3.397ProAla: 3.397 ± 0.411
0.419ProCys: 0.419 ± 0.16
2.6ProAsp: 2.6 ± 0.34
3.691ProGlu: 3.691 ± 0.426
2.181ProPhe: 2.181 ± 0.462
1.804ProGly: 1.804 ± 0.367
0.587ProHis: 0.587 ± 0.173
1.887ProIle: 1.887 ± 0.283
2.559ProLys: 2.559 ± 0.32
2.81ProLeu: 2.81 ± 0.275
1.049ProMet: 1.049 ± 0.222
1.762ProAsn: 1.762 ± 0.323
1.426ProPro: 1.426 ± 0.287
1.678ProGln: 1.678 ± 0.277
1.552ProArg: 1.552 ± 0.239
2.391ProSer: 2.391 ± 0.385
2.642ProThr: 2.642 ± 0.409
3.607ProVal: 3.607 ± 0.469
0.377ProTrp: 0.377 ± 0.109
1.468ProTyr: 1.468 ± 0.296
0.0ProXaa: 0.0 ± 0.0
Gln
3.313GlnAla: 3.313 ± 0.475
0.21GlnCys: 0.21 ± 0.093
1.72GlnAsp: 1.72 ± 0.258
2.726GlnGlu: 2.726 ± 0.447
1.887GlnPhe: 1.887 ± 0.306
2.475GlnGly: 2.475 ± 0.374
0.629GlnHis: 0.629 ± 0.183
2.013GlnIle: 2.013 ± 0.311
1.971GlnLys: 1.971 ± 0.305
2.6GlnLeu: 2.6 ± 0.383
1.845GlnMet: 1.845 ± 0.308
1.678GlnAsn: 1.678 ± 0.384
2.013GlnPro: 2.013 ± 0.32
2.013GlnGln: 2.013 ± 0.404
2.517GlnArg: 2.517 ± 0.353
2.223GlnSer: 2.223 ± 0.328
2.391GlnThr: 2.391 ± 0.288
2.265GlnVal: 2.265 ± 0.329
0.629GlnTrp: 0.629 ± 0.197
1.804GlnTyr: 1.804 ± 0.263
0.0GlnXaa: 0.0 ± 0.0
Arg
4.027ArgAla: 4.027 ± 0.489
0.336ArgCys: 0.336 ± 0.132
3.649ArgAsp: 3.649 ± 0.344
3.691ArgGlu: 3.691 ± 0.353
2.223ArgPhe: 2.223 ± 0.389
3.02ArgGly: 3.02 ± 0.377
1.091ArgHis: 1.091 ± 0.193
2.475ArgIle: 2.475 ± 0.329
3.523ArgLys: 3.523 ± 0.399
3.439ArgLeu: 3.439 ± 0.384
1.3ArgMet: 1.3 ± 0.241
3.313ArgAsn: 3.313 ± 0.417
1.3ArgPro: 1.3 ± 0.272
1.845ArgGln: 1.845 ± 0.325
2.978ArgArg: 2.978 ± 0.466
2.684ArgSer: 2.684 ± 0.256
2.475ArgThr: 2.475 ± 0.293
3.817ArgVal: 3.817 ± 0.441
0.671ArgTrp: 0.671 ± 0.21
1.594ArgTyr: 1.594 ± 0.216
0.0ArgXaa: 0.0 ± 0.0
Ser
5.411SerAla: 5.411 ± 0.571
0.671SerCys: 0.671 ± 0.18
3.649SerAsp: 3.649 ± 0.403
4.488SerGlu: 4.488 ± 0.378
2.307SerPhe: 2.307 ± 0.278
4.823SerGly: 4.823 ± 0.533
1.468SerHis: 1.468 ± 0.251
3.188SerIle: 3.188 ± 0.284
4.236SerLys: 4.236 ± 0.445
4.572SerLeu: 4.572 ± 0.483
1.762SerMet: 1.762 ± 0.227
3.355SerAsn: 3.355 ± 0.494
2.6SerPro: 2.6 ± 0.346
2.055SerGln: 2.055 ± 0.302
2.055SerArg: 2.055 ± 0.236
3.943SerSer: 3.943 ± 0.506
3.313SerThr: 3.313 ± 0.364
3.691SerVal: 3.691 ± 0.413
1.049SerTrp: 1.049 ± 0.238
1.845SerTyr: 1.845 ± 0.234
0.0SerXaa: 0.0 ± 0.0
Thr
4.194ThrAla: 4.194 ± 0.536
0.671ThrCys: 0.671 ± 0.189
3.859ThrAsp: 3.859 ± 0.413
3.272ThrGlu: 3.272 ± 0.301
2.433ThrPhe: 2.433 ± 0.33
4.865ThrGly: 4.865 ± 0.515
1.342ThrHis: 1.342 ± 0.268
3.146ThrIle: 3.146 ± 0.352
2.642ThrLys: 2.642 ± 0.396
3.691ThrLeu: 3.691 ± 0.405
1.216ThrMet: 1.216 ± 0.207
3.188ThrAsn: 3.188 ± 0.379
2.684ThrPro: 2.684 ± 0.345
2.223ThrGln: 2.223 ± 0.343
3.02ThrArg: 3.02 ± 0.375
3.817ThrSer: 3.817 ± 0.471
3.775ThrThr: 3.775 ± 0.478
4.152ThrVal: 4.152 ± 0.449
0.965ThrTrp: 0.965 ± 0.273
2.223ThrTyr: 2.223 ± 0.332
0.0ThrXaa: 0.0 ± 0.0
Val
5.704ValAla: 5.704 ± 0.556
0.755ValCys: 0.755 ± 0.191
5.285ValAsp: 5.285 ± 0.433
4.698ValGlu: 4.698 ± 0.492
2.181ValPhe: 2.181 ± 0.365
5.033ValGly: 5.033 ± 0.439
0.965ValHis: 0.965 ± 0.195
3.985ValIle: 3.985 ± 0.506
5.285ValLys: 5.285 ± 0.588
4.404ValLeu: 4.404 ± 0.45
2.097ValMet: 2.097 ± 0.295
3.062ValAsn: 3.062 ± 0.415
2.768ValPro: 2.768 ± 0.329
2.391ValGln: 2.391 ± 0.281
3.02ValArg: 3.02 ± 0.338
4.11ValSer: 4.11 ± 0.409
4.614ValThr: 4.614 ± 0.46
4.278ValVal: 4.278 ± 0.513
0.923ValTrp: 0.923 ± 0.187
1.887ValTyr: 1.887 ± 0.343
0.0ValXaa: 0.0 ± 0.0
Trp
1.174TrpAla: 1.174 ± 0.23
0.377TrpCys: 0.377 ± 0.134
0.839TrpAsp: 0.839 ± 0.215
1.216TrpGlu: 1.216 ± 0.207
0.839TrpPhe: 0.839 ± 0.188
1.091TrpGly: 1.091 ± 0.193
0.294TrpHis: 0.294 ± 0.119
0.923TrpIle: 0.923 ± 0.164
1.049TrpLys: 1.049 ± 0.223
1.007TrpLeu: 1.007 ± 0.21
0.629TrpMet: 0.629 ± 0.151
0.923TrpAsn: 0.923 ± 0.22
0.461TrpPro: 0.461 ± 0.136
0.503TrpGln: 0.503 ± 0.138
0.503TrpArg: 0.503 ± 0.137
1.007TrpSer: 1.007 ± 0.244
1.258TrpThr: 1.258 ± 0.317
0.965TrpVal: 0.965 ± 0.207
0.377TrpTrp: 0.377 ± 0.108
0.629TrpTyr: 0.629 ± 0.152
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.936TyrAla: 2.936 ± 0.369
0.545TyrCys: 0.545 ± 0.143
2.684TyrAsp: 2.684 ± 0.368
2.642TyrGlu: 2.642 ± 0.392
1.132TyrPhe: 1.132 ± 0.235
2.81TyrGly: 2.81 ± 0.305
1.132TyrHis: 1.132 ± 0.228
1.845TyrIle: 1.845 ± 0.287
2.81TyrLys: 2.81 ± 0.294
2.181TyrLeu: 2.181 ± 0.308
0.965TyrMet: 0.965 ± 0.197
2.349TyrAsn: 2.349 ± 0.291
1.845TyrPro: 1.845 ± 0.296
1.342TyrGln: 1.342 ± 0.228
1.887TyrArg: 1.887 ± 0.315
2.055TyrSer: 2.055 ± 0.29
1.804TyrThr: 1.804 ± 0.285
2.139TyrVal: 2.139 ± 0.34
0.629TyrTrp: 0.629 ± 0.181
1.468TyrTyr: 1.468 ± 0.283
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 115 proteins (23843 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski