Amino acid dipepetide frequency for Rotavirus A (isolate RVA/Human/United Kingdom/A64/1987/G10P11[14]) (RV-A)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.233AlaAla: 3.233 ± 0.493
1.455AlaCys: 1.455 ± 0.463
2.91AlaAsp: 2.91 ± 0.429
2.586AlaGlu: 2.586 ± 0.671
2.425AlaPhe: 2.425 ± 0.554
1.617AlaGly: 1.617 ± 0.532
0.485AlaHis: 0.485 ± 0.223
3.233AlaIle: 3.233 ± 0.571
2.425AlaLys: 2.425 ± 0.946
4.365AlaLeu: 4.365 ± 0.738
1.778AlaMet: 1.778 ± 0.368
4.688AlaAsn: 4.688 ± 0.595
1.455AlaPro: 1.455 ± 0.4
2.263AlaGln: 2.263 ± 0.569
3.556AlaArg: 3.556 ± 0.761
3.556AlaSer: 3.556 ± 0.648
3.233AlaThr: 3.233 ± 0.674
4.526AlaVal: 4.526 ± 0.601
0.162AlaTrp: 0.162 ± 0.153
1.293AlaTyr: 1.293 ± 0.59
0.0AlaXaa: 0.0 ± 0.0
Cys
0.808CysAla: 0.808 ± 0.388
0.485CysCys: 0.485 ± 0.295
0.808CysAsp: 0.808 ± 0.32
0.485CysGlu: 0.485 ± 0.288
0.647CysPhe: 0.647 ± 0.287
0.0CysGly: 0.0 ± 0.0
0.0CysHis: 0.0 ± 0.0
0.647CysIle: 0.647 ± 0.235
1.293CysLys: 1.293 ± 0.728
0.97CysLeu: 0.97 ± 0.382
0.647CysMet: 0.647 ± 0.297
0.97CysAsn: 0.97 ± 0.441
0.323CysPro: 0.323 ± 0.269
1.293CysGln: 1.293 ± 0.627
0.647CysArg: 0.647 ± 0.323
0.97CysSer: 0.97 ± 0.405
0.647CysThr: 0.647 ± 0.393
0.485CysVal: 0.485 ± 0.19
0.0CysTrp: 0.0 ± 0.0
0.485CysTyr: 0.485 ± 0.23
0.0CysXaa: 0.0 ± 0.0
Asp
3.233AspAla: 3.233 ± 0.741
0.808AspCys: 0.808 ± 0.458
4.041AspAsp: 4.041 ± 0.763
4.203AspGlu: 4.203 ± 0.407
3.233AspPhe: 3.233 ± 0.553
2.748AspGly: 2.748 ± 0.447
0.808AspHis: 0.808 ± 0.445
4.688AspIle: 4.688 ± 0.884
2.748AspLys: 2.748 ± 0.546
3.88AspLeu: 3.88 ± 0.606
1.778AspMet: 1.778 ± 0.356
3.233AspAsn: 3.233 ± 0.702
1.617AspPro: 1.617 ± 0.485
2.425AspGln: 2.425 ± 0.713
2.425AspArg: 2.425 ± 0.714
4.688AspSer: 4.688 ± 1.144
2.91AspThr: 2.91 ± 0.667
5.173AspVal: 5.173 ± 0.774
0.97AspTrp: 0.97 ± 0.308
4.85AspTyr: 4.85 ± 0.802
0.0AspXaa: 0.0 ± 0.0
Glu
2.586GluAla: 2.586 ± 0.629
0.0GluCys: 0.0 ± 0.0
3.395GluAsp: 3.395 ± 0.549
2.91GluGlu: 2.91 ± 0.668
2.102GluPhe: 2.102 ± 0.663
1.132GluGly: 1.132 ± 0.323
1.293GluHis: 1.293 ± 0.517
4.203GluIle: 4.203 ± 0.851
4.203GluLys: 4.203 ± 0.885
5.335GluLeu: 5.335 ± 0.83
2.263GluMet: 2.263 ± 0.47
3.718GluAsn: 3.718 ± 0.627
1.94GluPro: 1.94 ± 0.597
1.617GluGln: 1.617 ± 0.47
2.102GluArg: 2.102 ± 0.447
3.88GluSer: 3.88 ± 0.71
2.586GluThr: 2.586 ± 0.583
3.718GluVal: 3.718 ± 0.866
1.455GluTrp: 1.455 ± 0.792
4.526GluTyr: 4.526 ± 0.898
0.0GluXaa: 0.0 ± 0.0
Phe
1.778PheAla: 1.778 ± 0.708
0.323PheCys: 0.323 ± 0.207
3.556PheAsp: 3.556 ± 0.586
2.425PheGlu: 2.425 ± 0.617
0.485PhePhe: 0.485 ± 0.394
1.617PheGly: 1.617 ± 0.513
1.132PheHis: 1.132 ± 0.378
4.365PheIle: 4.365 ± 0.994
4.203PheLys: 4.203 ± 0.904
3.395PheLeu: 3.395 ± 1.048
0.323PheMet: 0.323 ± 0.263
3.395PheAsn: 3.395 ± 0.657
1.617PhePro: 1.617 ± 0.78
1.778PheGln: 1.778 ± 0.655
2.425PheArg: 2.425 ± 0.563
3.556PheSer: 3.556 ± 0.731
2.425PheThr: 2.425 ± 0.572
0.97PheVal: 0.97 ± 0.573
0.162PheTrp: 0.162 ± 0.131
1.94PheTyr: 1.94 ± 0.497
0.0PheXaa: 0.0 ± 0.0
Gly
1.94GlyAla: 1.94 ± 0.511
0.97GlyCys: 0.97 ± 0.366
1.132GlyAsp: 1.132 ± 0.421
1.617GlyGlu: 1.617 ± 0.611
0.97GlyPhe: 0.97 ± 0.407
1.617GlyGly: 1.617 ± 0.596
1.293GlyHis: 1.293 ± 0.438
4.85GlyIle: 4.85 ± 0.772
2.91GlyLys: 2.91 ± 0.631
2.102GlyLeu: 2.102 ± 0.468
0.97GlyMet: 0.97 ± 0.373
1.293GlyAsn: 1.293 ± 0.472
1.293GlyPro: 1.293 ± 0.424
1.293GlyGln: 1.293 ± 0.238
1.455GlyArg: 1.455 ± 0.601
2.263GlySer: 2.263 ± 0.677
2.586GlyThr: 2.586 ± 0.829
2.102GlyVal: 2.102 ± 0.411
0.647GlyTrp: 0.647 ± 0.325
0.808GlyTyr: 0.808 ± 0.294
0.0GlyXaa: 0.0 ± 0.0
His
0.808HisAla: 0.808 ± 0.257
0.162HisCys: 0.162 ± 0.156
0.97HisAsp: 0.97 ± 0.333
0.97HisGlu: 0.97 ± 0.454
0.162HisPhe: 0.162 ± 0.148
0.323HisGly: 0.323 ± 0.237
0.485HisHis: 0.485 ± 0.286
0.808HisIle: 0.808 ± 0.361
0.97HisLys: 0.97 ± 0.431
1.94HisLeu: 1.94 ± 0.679
0.323HisMet: 0.323 ± 0.189
0.808HisAsn: 0.808 ± 0.332
0.485HisPro: 0.485 ± 0.284
1.132HisGln: 1.132 ± 0.673
0.162HisArg: 0.162 ± 0.158
1.617HisSer: 1.617 ± 0.553
0.647HisThr: 0.647 ± 0.367
1.132HisVal: 1.132 ± 0.327
0.162HisTrp: 0.162 ± 0.124
1.455HisTyr: 1.455 ± 0.544
0.0HisXaa: 0.0 ± 0.0
Ile
5.496IleAla: 5.496 ± 0.94
0.647IleCys: 0.647 ± 0.256
3.233IleAsp: 3.233 ± 0.953
4.365IleGlu: 4.365 ± 1.071
2.91IlePhe: 2.91 ± 0.757
2.586IleGly: 2.586 ± 0.634
0.485IleHis: 0.485 ± 0.461
4.688IleIle: 4.688 ± 0.792
4.203IleLys: 4.203 ± 0.745
6.305IleLeu: 6.305 ± 1.064
1.617IleMet: 1.617 ± 0.334
6.628IleAsn: 6.628 ± 1.083
3.556IlePro: 3.556 ± 0.763
3.395IleGln: 3.395 ± 0.725
3.88IleArg: 3.88 ± 0.514
6.628IleSer: 6.628 ± 1.638
6.79IleThr: 6.79 ± 1.197
4.203IleVal: 4.203 ± 0.571
0.323IleTrp: 0.323 ± 0.199
4.041IleTyr: 4.041 ± 1.167
0.0IleXaa: 0.0 ± 0.0
Lys
1.455LysAla: 1.455 ± 0.57
1.132LysCys: 1.132 ± 0.343
2.586LysAsp: 2.586 ± 0.595
4.041LysGlu: 4.041 ± 1.111
3.395LysPhe: 3.395 ± 0.76
2.102LysGly: 2.102 ± 0.629
0.808LysHis: 0.808 ± 0.439
4.203LysIle: 4.203 ± 1.17
4.041LysLys: 4.041 ± 0.693
8.244LysLeu: 8.244 ± 1.035
2.586LysMet: 2.586 ± 0.646
3.071LysAsn: 3.071 ± 0.848
2.263LysPro: 2.263 ± 0.623
2.748LysGln: 2.748 ± 0.66
3.718LysArg: 3.718 ± 0.476
3.88LysSer: 3.88 ± 0.917
3.88LysThr: 3.88 ± 0.925
3.718LysVal: 3.718 ± 0.816
1.293LysTrp: 1.293 ± 0.719
3.071LysTyr: 3.071 ± 1.243
0.0LysXaa: 0.0 ± 0.0
Leu
3.556LeuAla: 3.556 ± 0.493
1.132LeuCys: 1.132 ± 0.566
6.466LeuAsp: 6.466 ± 0.975
5.496LeuGlu: 5.496 ± 1.245
4.365LeuPhe: 4.365 ± 0.765
2.586LeuGly: 2.586 ± 0.539
1.94LeuHis: 1.94 ± 0.733
7.274LeuIle: 7.274 ± 0.594
5.335LeuLys: 5.335 ± 0.804
7.436LeuLeu: 7.436 ± 1.469
4.203LeuMet: 4.203 ± 0.85
6.466LeuAsn: 6.466 ± 0.913
4.041LeuPro: 4.041 ± 0.629
3.556LeuGln: 3.556 ± 0.897
4.85LeuArg: 4.85 ± 0.696
8.891LeuSer: 8.891 ± 1.337
5.82LeuThr: 5.82 ± 0.838
5.011LeuVal: 5.011 ± 0.773
0.808LeuTrp: 0.808 ± 0.333
4.041LeuTyr: 4.041 ± 0.786
0.0LeuXaa: 0.0 ± 0.0
Met
2.102MetAla: 2.102 ± 0.41
0.0MetCys: 0.0 ± 0.0
4.041MetAsp: 4.041 ± 0.685
1.293MetGlu: 1.293 ± 0.57
1.455MetPhe: 1.455 ± 0.388
0.97MetGly: 0.97 ± 0.399
0.485MetHis: 0.485 ± 0.289
0.97MetIle: 0.97 ± 0.328
1.617MetLys: 1.617 ± 0.473
3.556MetLeu: 3.556 ± 0.704
0.808MetMet: 0.808 ± 0.483
2.263MetAsn: 2.263 ± 0.574
0.808MetPro: 0.808 ± 0.31
2.263MetGln: 2.263 ± 1.042
2.91MetArg: 2.91 ± 0.742
2.586MetSer: 2.586 ± 0.481
1.455MetThr: 1.455 ± 0.406
0.808MetVal: 0.808 ± 0.336
0.647MetTrp: 0.647 ± 0.271
1.132MetTyr: 1.132 ± 0.336
0.0MetXaa: 0.0 ± 0.0
Asn
4.365AsnAla: 4.365 ± 0.88
0.808AsnCys: 0.808 ± 0.484
4.85AsnAsp: 4.85 ± 1.02
4.688AsnGlu: 4.688 ± 0.823
1.94AsnPhe: 1.94 ± 0.62
3.395AsnGly: 3.395 ± 0.513
1.617AsnHis: 1.617 ± 0.688
3.233AsnIle: 3.233 ± 0.715
4.041AsnLys: 4.041 ± 0.831
7.274AsnLeu: 7.274 ± 0.746
2.425AsnMet: 2.425 ± 0.665
5.335AsnAsn: 5.335 ± 1.109
1.617AsnPro: 1.617 ± 0.731
2.102AsnGln: 2.102 ± 0.668
2.263AsnArg: 2.263 ± 0.41
5.981AsnSer: 5.981 ± 0.885
3.556AsnThr: 3.556 ± 0.953
5.011AsnVal: 5.011 ± 0.637
1.617AsnTrp: 1.617 ± 0.645
5.011AsnTyr: 5.011 ± 0.767
0.0AsnXaa: 0.0 ± 0.0
Pro
1.617ProAla: 1.617 ± 0.541
0.0ProCys: 0.0 ± 0.0
1.778ProAsp: 1.778 ± 0.527
0.647ProGlu: 0.647 ± 0.3
2.263ProPhe: 2.263 ± 0.325
1.293ProGly: 1.293 ± 0.407
0.647ProHis: 0.647 ± 0.304
3.718ProIle: 3.718 ± 0.356
1.293ProLys: 1.293 ± 0.458
1.778ProLeu: 1.778 ± 0.456
1.132ProMet: 1.132 ± 0.412
1.617ProAsn: 1.617 ± 0.729
0.808ProPro: 0.808 ± 0.54
1.455ProGln: 1.455 ± 0.607
1.455ProArg: 1.455 ± 0.271
2.102ProSer: 2.102 ± 0.589
3.718ProThr: 3.718 ± 0.985
2.586ProVal: 2.586 ± 0.789
0.0ProTrp: 0.0 ± 0.0
1.617ProTyr: 1.617 ± 0.551
0.0ProXaa: 0.0 ± 0.0
Gln
1.617GlnAla: 1.617 ± 0.462
0.485GlnCys: 0.485 ± 0.214
1.94GlnAsp: 1.94 ± 0.628
1.132GlnGlu: 1.132 ± 0.384
2.102GlnPhe: 2.102 ± 0.594
0.323GlnGly: 0.323 ± 0.218
1.132GlnHis: 1.132 ± 0.374
4.365GlnIle: 4.365 ± 0.665
2.425GlnLys: 2.425 ± 0.683
5.496GlnLeu: 5.496 ± 1.234
1.617GlnMet: 1.617 ± 0.516
2.586GlnAsn: 2.586 ± 0.571
1.132GlnPro: 1.132 ± 0.38
2.425GlnGln: 2.425 ± 0.963
2.425GlnArg: 2.425 ± 0.686
2.102GlnSer: 2.102 ± 0.374
4.688GlnThr: 4.688 ± 1.287
2.425GlnVal: 2.425 ± 0.683
0.485GlnTrp: 0.485 ± 0.277
2.586GlnTyr: 2.586 ± 0.499
0.0GlnXaa: 0.0 ± 0.0
Arg
1.778ArgAla: 1.778 ± 0.569
0.647ArgCys: 0.647 ± 0.328
2.102ArgAsp: 2.102 ± 0.52
3.88ArgGlu: 3.88 ± 0.526
2.102ArgPhe: 2.102 ± 0.644
1.778ArgGly: 1.778 ± 0.482
0.808ArgHis: 0.808 ± 0.225
3.071ArgIle: 3.071 ± 0.394
2.586ArgLys: 2.586 ± 0.589
5.011ArgLeu: 5.011 ± 0.991
2.586ArgMet: 2.586 ± 0.732
4.526ArgAsn: 4.526 ± 1.383
0.808ArgPro: 0.808 ± 0.439
2.263ArgGln: 2.263 ± 0.787
1.94ArgArg: 1.94 ± 0.605
3.556ArgSer: 3.556 ± 0.658
2.586ArgThr: 2.586 ± 0.46
3.88ArgVal: 3.88 ± 0.997
0.808ArgTrp: 0.808 ± 0.296
2.263ArgTyr: 2.263 ± 0.538
0.0ArgXaa: 0.0 ± 0.0
Ser
3.556SerAla: 3.556 ± 0.587
0.808SerCys: 0.808 ± 0.362
4.526SerAsp: 4.526 ± 1.132
4.203SerGlu: 4.203 ± 0.95
2.91SerPhe: 2.91 ± 0.88
2.748SerGly: 2.748 ± 0.761
0.808SerHis: 0.808 ± 0.335
7.274SerIle: 7.274 ± 1.141
4.526SerLys: 4.526 ± 0.826
6.79SerLeu: 6.79 ± 0.989
2.102SerMet: 2.102 ± 0.431
6.466SerAsn: 6.466 ± 1.403
1.94SerPro: 1.94 ± 0.562
4.203SerGln: 4.203 ± 0.622
4.526SerArg: 4.526 ± 0.687
5.496SerSer: 5.496 ± 1.633
6.143SerThr: 6.143 ± 1.223
4.85SerVal: 4.85 ± 0.632
0.485SerTrp: 0.485 ± 0.282
3.556SerTyr: 3.556 ± 0.946
0.0SerXaa: 0.0 ± 0.0
Thr
3.233ThrAla: 3.233 ± 0.69
0.323ThrCys: 0.323 ± 0.248
4.041ThrAsp: 4.041 ± 0.726
2.91ThrGlu: 2.91 ± 0.792
4.203ThrPhe: 4.203 ± 0.609
2.748ThrGly: 2.748 ± 0.716
0.485ThrHis: 0.485 ± 0.277
5.011ThrIle: 5.011 ± 1.004
3.88ThrLys: 3.88 ± 0.689
8.729ThrLeu: 8.729 ± 1.505
2.263ThrMet: 2.263 ± 0.603
4.203ThrAsn: 4.203 ± 0.73
1.778ThrPro: 1.778 ± 0.346
2.91ThrGln: 2.91 ± 0.913
2.586ThrArg: 2.586 ± 0.628
5.82ThrSer: 5.82 ± 0.875
6.305ThrThr: 6.305 ± 1.118
3.395ThrVal: 3.395 ± 0.768
0.647ThrTrp: 0.647 ± 0.293
2.263ThrTyr: 2.263 ± 0.558
0.0ThrXaa: 0.0 ± 0.0
Val
4.688ValAla: 4.688 ± 0.81
1.132ValCys: 1.132 ± 0.484
4.041ValAsp: 4.041 ± 0.814
4.041ValGlu: 4.041 ± 0.824
1.778ValPhe: 1.778 ± 0.434
2.425ValGly: 2.425 ± 0.419
0.162ValHis: 0.162 ± 0.156
4.041ValIle: 4.041 ± 0.568
4.365ValLys: 4.365 ± 0.617
6.143ValLeu: 6.143 ± 0.771
1.132ValMet: 1.132 ± 0.441
5.011ValAsn: 5.011 ± 0.997
2.425ValPro: 2.425 ± 0.644
1.94ValGln: 1.94 ± 0.427
2.586ValArg: 2.586 ± 0.383
4.85ValSer: 4.85 ± 1.05
3.88ValThr: 3.88 ± 0.594
3.071ValVal: 3.071 ± 0.587
0.162ValTrp: 0.162 ± 0.156
3.071ValTyr: 3.071 ± 0.403
0.0ValXaa: 0.0 ± 0.0
Trp
0.162TrpAla: 0.162 ± 0.131
0.485TrpCys: 0.485 ± 0.468
0.97TrpAsp: 0.97 ± 0.311
0.323TrpGlu: 0.323 ± 0.312
0.323TrpPhe: 0.323 ± 0.193
0.162TrpGly: 0.162 ± 0.153
0.0TrpHis: 0.0 ± 0.0
1.132TrpIle: 1.132 ± 0.493
1.617TrpLys: 1.617 ± 0.347
1.293TrpLeu: 1.293 ± 0.307
0.485TrpMet: 0.485 ± 0.336
0.647TrpAsn: 0.647 ± 0.335
0.323TrpPro: 0.323 ± 0.269
0.647TrpGln: 0.647 ± 0.456
0.485TrpArg: 0.485 ± 0.237
0.485TrpSer: 0.485 ± 0.223
0.647TrpThr: 0.647 ± 0.303
0.485TrpVal: 0.485 ± 0.235
0.323TrpTrp: 0.323 ± 0.269
0.97TrpTyr: 0.97 ± 0.319
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.233TyrAla: 3.233 ± 0.862
0.808TyrCys: 0.808 ± 0.397
3.071TyrAsp: 3.071 ± 0.812
2.748TyrGlu: 2.748 ± 0.556
2.102TyrPhe: 2.102 ± 0.468
1.94TyrGly: 1.94 ± 0.636
0.647TyrHis: 0.647 ± 0.48
4.203TyrIle: 4.203 ± 0.554
3.556TyrLys: 3.556 ± 0.684
3.233TyrLeu: 3.233 ± 0.894
0.97TyrMet: 0.97 ± 0.344
4.203TyrAsn: 4.203 ± 0.626
1.293TyrPro: 1.293 ± 0.35
1.778TyrGln: 1.778 ± 0.405
2.586TyrArg: 2.586 ± 0.581
5.011TyrSer: 5.011 ± 1.387
3.233TyrThr: 3.233 ± 0.804
3.556TyrVal: 3.556 ± 0.685
0.808TyrTrp: 0.808 ± 0.444
2.91TyrTyr: 2.91 ± 0.955
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 13 proteins (6187 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski