Amino acid dipepetide frequency for Bifidobacterium animalis subsp. lactis (strain AD011)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	11.802AlaAla: 11.802 ± 0.229	1.146AlaCys: 1.146 ± 0.048	6.995AlaAsp: 6.995 ± 0.127	5.853AlaGlu: 5.853 ± 0.113	3.496AlaPhe: 3.496 ± 0.083	8.151AlaGly: 8.151 ± 0.13	2.608AlaHis: 2.608 ± 0.072	5.683AlaIle: 5.683 ± 0.119	4.557AlaLys: 4.557 ± 0.112	10.125AlaLeu: 10.125 ± 0.149	3.371AlaMet: 3.371 ± 0.081	3.828AlaAsn: 3.828 ± 0.107	4.032AlaPro: 4.032 ± 0.103	5.007AlaGln: 5.007 ± 0.1	6.472AlaArg: 6.472 ± 0.135	5.764AlaSer: 5.764 ± 0.12	5.458AlaThr: 5.458 ± 0.109	8.105AlaVal: 8.105 ± 0.144	1.36AlaTrp: 1.36 ± 0.057	2.72AlaTyr: 2.72 ± 0.068	0.0AlaXaa: 0.0 ± 0.0
Cys	1.275CysAla: 1.275 ± 0.056	0.144CysCys: 0.144 ± 0.017	0.571CysAsp: 0.571 ± 0.034	0.614CysGlu: 0.614 ± 0.037	0.337CysPhe: 0.337 ± 0.027	0.977CysGly: 0.977 ± 0.043	0.208CysHis: 0.208 ± 0.019	0.475CysIle: 0.475 ± 0.032	0.245CysLys: 0.245 ± 0.02	0.792CysLeu: 0.792 ± 0.043	0.278CysMet: 0.278 ± 0.028	0.264CysAsn: 0.264 ± 0.021	0.474CysPro: 0.474 ± 0.031	0.199CysGln: 0.199 ± 0.019	0.619CysArg: 0.619 ± 0.037	0.674CysSer: 0.674 ± 0.035	0.601CysThr: 0.601 ± 0.035	0.938CysVal: 0.938 ± 0.047	0.147CysTrp: 0.147 ± 0.017	0.267CysTyr: 0.267 ± 0.024	0.0CysXaa: 0.0 ± 0.0
Asp	7.353AspAla: 7.353 ± 0.133	0.604AspCys: 0.604 ± 0.034	4.69AspAsp: 4.69 ± 0.111	5.213AspGlu: 5.213 ± 0.117	2.296AspPhe: 2.296 ± 0.073	5.523AspGly: 5.523 ± 0.122	1.347AspHis: 1.347 ± 0.057	3.256AspIle: 3.256 ± 0.077	2.034AspLys: 2.034 ± 0.06	5.403AspLeu: 5.403 ± 0.113	1.835AspMet: 1.835 ± 0.06	1.741AspAsn: 1.741 ± 0.058	3.601AspPro: 3.601 ± 0.082	1.657AspGln: 1.657 ± 0.058	3.236AspArg: 3.236 ± 0.075	3.651AspSer: 3.651 ± 0.086	3.142AspThr: 3.142 ± 0.075	5.127AspVal: 5.127 ± 0.105	0.984AspTrp: 0.984 ± 0.049	1.948AspTyr: 1.948 ± 0.069	0.0AspXaa: 0.0 ± 0.0
Glu	6.03GluAla: 6.03 ± 0.139	0.494GluCys: 0.494 ± 0.033	3.225GluAsp: 3.225 ± 0.088	3.798GluGlu: 3.798 ± 0.115	1.981GluPhe: 1.981 ± 0.06	4.086GluGly: 4.086 ± 0.094	2.162GluHis: 2.162 ± 0.066	3.022GluIle: 3.022 ± 0.08	2.082GluLys: 2.082 ± 0.071	5.707GluLeu: 5.707 ± 0.112	1.601GluMet: 1.601 ± 0.055	2.042GluAsn: 2.042 ± 0.061	3.026GluPro: 3.026 ± 0.081	3.304GluGln: 3.304 ± 0.088	4.928GluArg: 4.928 ± 0.112	3.448GluSer: 3.448 ± 0.082	3.207GluThr: 3.207 ± 0.088	4.027GluVal: 4.027 ± 0.073	0.724GluTrp: 0.724 ± 0.04	1.898GluTyr: 1.898 ± 0.067	0.0GluXaa: 0.0 ± 0.0
Phe	4.014PheAla: 4.014 ± 0.1	0.343PheCys: 0.343 ± 0.027	2.709PheAsp: 2.709 ± 0.069	2.014PheGlu: 2.014 ± 0.068	1.202PhePhe: 1.202 ± 0.041	3.282PheGly: 3.282 ± 0.082	0.813PheHis: 0.813 ± 0.04	1.843PheIle: 1.843 ± 0.073	1.109PheLys: 1.109 ± 0.048	2.689PheLeu: 2.689 ± 0.082	0.842PheMet: 0.842 ± 0.045	1.253PheAsn: 1.253 ± 0.052	1.369PhePro: 1.369 ± 0.055	0.868PheGln: 0.868 ± 0.038	1.706PheArg: 1.706 ± 0.057	2.195PheSer: 2.195 ± 0.062	2.331PheThr: 2.331 ± 0.07	2.709PheVal: 2.709 ± 0.071	0.45PheTrp: 0.45 ± 0.029	0.971PheTyr: 0.971 ± 0.044	0.0PheXaa: 0.0 ± 0.0
Gly	7.174GlyAla: 7.174 ± 0.112	0.861GlyCys: 0.861 ± 0.043	4.721GlyAsp: 4.721 ± 0.096	5.151GlyGlu: 5.151 ± 0.101	3.089GlyPhe: 3.089 ± 0.083	5.619GlyGly: 5.619 ± 0.117	1.732GlyHis: 1.732 ± 0.061	4.74GlyIle: 4.74 ± 0.106	3.571GlyLys: 3.571 ± 0.088	6.487GlyLeu: 6.487 ± 0.109	2.477GlyMet: 2.477 ± 0.06	2.832GlyAsn: 2.832 ± 0.084	2.504GlyPro: 2.504 ± 0.078	2.495GlyGln: 2.495 ± 0.075	4.395GlyArg: 4.395 ± 0.098	4.828GlySer: 4.828 ± 0.106	4.915GlyThr: 4.915 ± 0.097	6.369GlyVal: 6.369 ± 0.116	1.143GlyTrp: 1.143 ± 0.048	2.521GlyTyr: 2.521 ± 0.069	0.0GlyXaa: 0.0 ± 0.0
His	2.777HisAla: 2.777 ± 0.099	0.245HisCys: 0.245 ± 0.022	1.885HisAsp: 1.885 ± 0.065	1.476HisGlu: 1.476 ± 0.055	0.652HisPhe: 0.652 ± 0.034	2.21HisGly: 2.21 ± 0.074	0.647HisHis: 0.647 ± 0.041	1.15HisIle: 1.15 ± 0.05	0.628HisLys: 0.628 ± 0.036	1.712HisLeu: 1.712 ± 0.059	0.75HisMet: 0.75 ± 0.039	0.768HisAsn: 0.768 ± 0.039	1.332HisPro: 1.332 ± 0.05	0.579HisGln: 0.579 ± 0.031	1.548HisArg: 1.548 ± 0.051	1.214HisSer: 1.214 ± 0.046	1.526HisThr: 1.526 ± 0.055	2.055HisVal: 2.055 ± 0.071	0.324HisTrp: 0.324 ± 0.027	0.658HisTyr: 0.658 ± 0.033	0.0HisXaa: 0.0 ± 0.0
Ile	6.785IleAla: 6.785 ± 0.121	0.756IleCys: 0.756 ± 0.037	4.294IleAsp: 4.294 ± 0.091	3.47IleGlu: 3.47 ± 0.094	1.579IlePhe: 1.579 ± 0.063	4.627IleGly: 4.627 ± 0.098	1.063IleHis: 1.063 ± 0.05	2.98IleIle: 2.98 ± 0.081	1.616IleLys: 1.616 ± 0.066	3.748IleLeu: 3.748 ± 0.099	1.347IleMet: 1.347 ± 0.05	1.705IleAsn: 1.705 ± 0.053	2.679IlePro: 2.679 ± 0.071	1.163IleGln: 1.163 ± 0.054	2.961IleArg: 2.961 ± 0.081	3.024IleSer: 3.024 ± 0.076	3.114IleThr: 3.114 ± 0.08	5.178IleVal: 5.178 ± 0.097	0.627IleTrp: 0.627 ± 0.033	1.179IleTyr: 1.179 ± 0.046	0.0IleXaa: 0.0 ± 0.0
Lys	4.181LysAla: 4.181 ± 0.107	0.17LysCys: 0.17 ± 0.016	2.119LysAsp: 2.119 ± 0.082	2.217LysGlu: 2.217 ± 0.081	1.004LysPhe: 1.004 ± 0.046	2.503LysGly: 2.503 ± 0.083	0.822LysHis: 0.822 ± 0.04	1.758LysIle: 1.758 ± 0.066	1.642LysLys: 1.642 ± 0.072	3.011LysLeu: 3.011 ± 0.081	0.932LysMet: 0.932 ± 0.048	1.279LysAsn: 1.279 ± 0.052	2.237LysPro: 2.237 ± 0.063	1.542LysGln: 1.542 ± 0.06	2.458LysArg: 2.458 ± 0.072	2.165LysSer: 2.165 ± 0.066	2.228LysThr: 2.228 ± 0.069	2.567LysVal: 2.567 ± 0.083	0.416LysTrp: 0.416 ± 0.028	1.058LysTyr: 1.058 ± 0.056	0.0LysXaa: 0.0 ± 0.0
Leu	9.926LeuAla: 9.926 ± 0.15	1.069LeuCys: 1.069 ± 0.047	6.197LeuAsp: 6.197 ± 0.116	4.92LeuGlu: 4.92 ± 0.104	3.214LeuPhe: 3.214 ± 0.087	7.115LeuGly: 7.115 ± 0.12	2.204LeuHis: 2.204 ± 0.075	4.559LeuIle: 4.559 ± 0.1	3.116LeuLys: 3.116 ± 0.075	7.661LeuLeu: 7.661 ± 0.155	2.377LeuMet: 2.377 ± 0.079	3.033LeuAsn: 3.033 ± 0.076	4.506LeuPro: 4.506 ± 0.087	2.705LeuGln: 2.705 ± 0.077	5.554LeuArg: 5.554 ± 0.117	5.14LeuSer: 5.14 ± 0.097	5.306LeuThr: 5.306 ± 0.113	6.242LeuVal: 6.242 ± 0.13	1.019LeuTrp: 1.019 ± 0.048	2.003LeuTyr: 2.003 ± 0.06	0.0LeuXaa: 0.0 ± 0.0
Met	2.995MetAla: 2.995 ± 0.08	0.282MetCys: 0.282 ± 0.023	1.452MetAsp: 1.452 ± 0.055	1.367MetGlu: 1.367 ± 0.048	0.944MetPhe: 0.944 ± 0.042	2.023MetGly: 2.023 ± 0.066	0.733MetHis: 0.733 ± 0.04	1.426MetIle: 1.426 ± 0.053	0.966MetLys: 0.966 ± 0.044	2.825MetLeu: 2.825 ± 0.088	0.708MetMet: 0.708 ± 0.04	1.039MetAsn: 1.039 ± 0.043	1.727MetPro: 1.727 ± 0.061	1.126MetGln: 1.126 ± 0.047	2.152MetArg: 2.152 ± 0.07	1.909MetSer: 1.909 ± 0.057	1.874MetThr: 1.874 ± 0.055	1.937MetVal: 1.937 ± 0.058	0.297MetTrp: 0.297 ± 0.024	0.604MetTyr: 0.604 ± 0.032	0.0MetXaa: 0.0 ± 0.0
Asn	4.038AsnAla: 4.038 ± 0.102	0.243AsnCys: 0.243 ± 0.022	2.195AsnAsp: 2.195 ± 0.069	2.186AsnGlu: 2.186 ± 0.067	0.938AsnPhe: 0.938 ± 0.041	3.437AsnGly: 3.437 ± 0.087	0.726AsnHis: 0.726 ± 0.034	1.668AsnIle: 1.668 ± 0.054	1.174AsnLys: 1.174 ± 0.052	2.936AsnLeu: 2.936 ± 0.086	0.929AsnMet: 0.929 ± 0.04	1.257AsnAsn: 1.257 ± 0.067	2.316AsnPro: 2.316 ± 0.064	0.973AsnGln: 0.973 ± 0.047	2.071AsnArg: 2.071 ± 0.055	1.684AsnSer: 1.684 ± 0.054	2.2AsnThr: 2.2 ± 0.069	2.521AsnVal: 2.521 ± 0.074	0.461AsnTrp: 0.461 ± 0.029	0.896AsnTyr: 0.896 ± 0.051	0.0AsnXaa: 0.0 ± 0.0
Pro	4.653ProAla: 4.653 ± 0.122	0.361ProCys: 0.361 ± 0.028	3.234ProAsp: 3.234 ± 0.083	3.404ProGlu: 3.404 ± 0.094	1.651ProPhe: 1.651 ± 0.056	3.452ProGly: 3.452 ± 0.086	1.13ProHis: 1.13 ± 0.044	2.374ProIle: 2.374 ± 0.06	1.802ProLys: 1.802 ± 0.064	3.848ProLeu: 3.848 ± 0.089	1.231ProMet: 1.231 ± 0.047	1.869ProAsn: 1.869 ± 0.064	1.325ProPro: 1.325 ± 0.054	2.287ProGln: 2.287 ± 0.064	2.449ProArg: 2.449 ± 0.068	2.967ProSer: 2.967 ± 0.095	2.89ProThr: 2.89 ± 0.076	3.796ProVal: 3.796 ± 0.09	0.7ProTrp: 0.7 ± 0.039	1.434ProTyr: 1.434 ± 0.059	0.0ProXaa: 0.0 ± 0.0
Gln	4.027GlnAla: 4.027 ± 0.092	0.308GlnCys: 0.308 ± 0.028	1.587GlnAsp: 1.587 ± 0.059	1.92GlnGlu: 1.92 ± 0.069	1.229GlnPhe: 1.229 ± 0.043	2.475GlnGly: 2.475 ± 0.066	0.931GlnHis: 0.931 ± 0.043	2.438GlnIle: 2.438 ± 0.066	1.01GlnLys: 1.01 ± 0.044	3.479GlnLeu: 3.479 ± 0.088	1.255GlnMet: 1.255 ± 0.049	1.137GlnAsn: 1.137 ± 0.056	1.69GlnPro: 1.69 ± 0.069	1.786GlnGln: 1.786 ± 0.06	2.398GlnArg: 2.398 ± 0.064	2.221GlnSer: 2.221 ± 0.067	2.215GlnThr: 2.215 ± 0.061	2.621GlnVal: 2.621 ± 0.076	0.645GlnTrp: 0.645 ± 0.038	1.187GlnTyr: 1.187 ± 0.054	0.0GlnXaa: 0.0 ± 0.0
Arg	5.764ArgAla: 5.764 ± 0.118	0.549ArgCys: 0.549 ± 0.035	3.713ArgAsp: 3.713 ± 0.088	4.279ArgGlu: 4.279 ± 0.096	2.46ArgPhe: 2.46 ± 0.074	3.829ArgGly: 3.829 ± 0.1	1.635ArgHis: 1.635 ± 0.052	3.748ArgIle: 3.748 ± 0.09	2.597ArgLys: 2.597 ± 0.077	5.405ArgLeu: 5.405 ± 0.113	2.029ArgMet: 2.029 ± 0.067	2.41ArgAsn: 2.41 ± 0.067	2.527ArgPro: 2.527 ± 0.07	2.445ArgGln: 2.445 ± 0.063	4.602ArgArg: 4.602 ± 0.127	3.284ArgSer: 3.284 ± 0.088	3.485ArgThr: 3.485 ± 0.081	4.386ArgVal: 4.386 ± 0.09	0.759ArgTrp: 0.759 ± 0.039	1.795ArgTyr: 1.795 ± 0.054	0.0ArgXaa: 0.0 ± 0.0
Ser	5.938SerAla: 5.938 ± 0.117	0.507SerCys: 0.507 ± 0.033	3.459SerAsp: 3.459 ± 0.078	3.173SerGlu: 3.173 ± 0.075	2.04SerPhe: 2.04 ± 0.058	5.007SerGly: 5.007 ± 0.107	1.345SerHis: 1.345 ± 0.055	3.12SerIle: 3.12 ± 0.075	2.141SerLys: 2.141 ± 0.072	5.276SerLeu: 5.276 ± 0.101	1.837SerMet: 1.837 ± 0.064	2.156SerAsn: 2.156 ± 0.072	2.51SerPro: 2.51 ± 0.077	2.307SerGln: 2.307 ± 0.071	3.459SerArg: 3.459 ± 0.095	3.721SerSer: 3.721 ± 0.103	3.535SerThr: 3.535 ± 0.088	4.406SerVal: 4.406 ± 0.103	0.85SerTrp: 0.85 ± 0.039	1.467SerTyr: 1.467 ± 0.048	0.0SerXaa: 0.0 ± 0.0
Thr	5.869ThrAla: 5.869 ± 0.11	0.498ThrCys: 0.498 ± 0.031	3.647ThrAsp: 3.647 ± 0.086	2.836ThrGlu: 2.836 ± 0.071	2.016ThrPhe: 2.016 ± 0.074	4.74ThrGly: 4.74 ± 0.095	1.402ThrHis: 1.402 ± 0.048	3.301ThrIle: 3.301 ± 0.088	2.138ThrLys: 2.138 ± 0.071	5.637ThrLeu: 5.637 ± 0.109	1.622ThrMet: 1.622 ± 0.058	1.979ThrAsn: 1.979 ± 0.064	3.315ThrPro: 3.315 ± 0.087	2.147ThrGln: 2.147 ± 0.06	3.212ThrArg: 3.212 ± 0.082	3.232ThrSer: 3.232 ± 0.085	3.531ThrThr: 3.531 ± 0.069	5.228ThrVal: 5.228 ± 0.128	0.698ThrTrp: 0.698 ± 0.037	1.568ThrTyr: 1.568 ± 0.054	0.0ThrXaa: 0.0 ± 0.0
Val	7.769ValAla: 7.769 ± 0.149	1.023ValCys: 1.023 ± 0.044	5.317ValAsp: 5.317 ± 0.097	4.69ValGlu: 4.69 ± 0.105	2.949ValPhe: 2.949 ± 0.086	5.315ValGly: 5.315 ± 0.108	1.74ValHis: 1.74 ± 0.064	4.393ValIle: 4.393 ± 0.095	2.632ValLys: 2.632 ± 0.086	7.384ValLeu: 7.384 ± 0.145	1.911ValMet: 1.911 ± 0.063	2.79ValAsn: 2.79 ± 0.08	3.903ValPro: 3.903 ± 0.086	2.425ValGln: 2.425 ± 0.069	4.727ValArg: 4.727 ± 0.091	4.766ValSer: 4.766 ± 0.105	4.751ValThr: 4.751 ± 0.111	6.548ValVal: 6.548 ± 0.127	0.997ValTrp: 0.997 ± 0.047	1.776ValTyr: 1.776 ± 0.061	0.0ValXaa: 0.0 ± 0.0
Trp	1.135TrpAla: 1.135 ± 0.048	0.19TrpCys: 0.19 ± 0.02	0.717TrpAsp: 0.717 ± 0.034	0.545TrpGlu: 0.545 ± 0.036	0.586TrpPhe: 0.586 ± 0.039	0.827TrpGly: 0.827 ± 0.037	0.363TrpHis: 0.363 ± 0.032	0.713TrpIle: 0.713 ± 0.039	0.514TrpLys: 0.514 ± 0.03	1.436TrpLeu: 1.436 ± 0.058	0.396TrpMet: 0.396 ± 0.025	0.597TrpAsn: 0.597 ± 0.031	0.538TrpPro: 0.538 ± 0.03	0.643TrpGln: 0.643 ± 0.034	0.977TrpArg: 0.977 ± 0.046	0.778TrpSer: 0.778 ± 0.042	0.687TrpThr: 0.687 ± 0.039	0.979TrpVal: 0.979 ± 0.039	0.256TrpTrp: 0.256 ± 0.021	0.38TrpTyr: 0.38 ± 0.026	0.0TrpXaa: 0.0 ± 0.0
Tyr	3.028TyrAla: 3.028 ± 0.076	0.31TyrCys: 0.31 ± 0.028	1.915TyrAsp: 1.915 ± 0.067	1.664TyrGlu: 1.664 ± 0.065	1.049TyrPhe: 1.049 ± 0.039	2.427TyrGly: 2.427 ± 0.067	0.527TyrHis: 0.527 ± 0.028	1.249TyrIle: 1.249 ± 0.048	0.737TyrLys: 0.737 ± 0.042	2.305TyrLeu: 2.305 ± 0.068	0.656TyrMet: 0.656 ± 0.035	0.868TyrAsn: 0.868 ± 0.04	1.244TyrPro: 1.244 ± 0.053	0.897TyrGln: 0.897 ± 0.049	1.776TyrArg: 1.776 ± 0.062	1.589TyrSer: 1.589 ± 0.049	1.622TyrThr: 1.622 ± 0.059	2.068TyrVal: 2.068 ± 0.068	0.4TyrTrp: 0.4 ± 0.027	0.772TyrTyr: 0.772 ± 0.038	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 1525 proteins (542643 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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