Amino acid dipepetide frequency for Rhizoctonia solani 123E

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	8.03AlaAla: 8.03 ± 0.05	1.137AlaCys: 1.137 ± 0.017	3.779AlaAsp: 3.779 ± 0.026	4.599AlaGlu: 4.599 ± 0.033	3.151AlaPhe: 3.151 ± 0.028	5.653AlaGly: 5.653 ± 0.038	2.161AlaHis: 2.161 ± 0.018	4.321AlaIle: 4.321 ± 0.035	3.848AlaLys: 3.848 ± 0.035	8.419AlaLeu: 8.419 ± 0.048	1.852AlaMet: 1.852 ± 0.017	2.946AlaAsn: 2.946 ± 0.028	5.528AlaPro: 5.528 ± 0.048	3.453AlaGln: 3.453 ± 0.027	5.387AlaArg: 5.387 ± 0.033	7.487AlaSer: 7.487 ± 0.046	5.415AlaThr: 5.415 ± 0.034	5.01AlaVal: 5.01 ± 0.031	1.168AlaTrp: 1.168 ± 0.016	2.328AlaTyr: 2.328 ± 0.021	0.0AlaXaa: 0.0 ± 0.0
Cys	0.956CysAla: 0.956 ± 0.014	0.215CysCys: 0.215 ± 0.007	0.691CysAsp: 0.691 ± 0.014	0.594CysGlu: 0.594 ± 0.011	0.497CysPhe: 0.497 ± 0.01	0.928CysGly: 0.928 ± 0.015	0.351CysHis: 0.351 ± 0.008	0.736CysIle: 0.736 ± 0.012	0.509CysLys: 0.509 ± 0.009	1.191CysLeu: 1.191 ± 0.015	0.261CysMet: 0.261 ± 0.007	0.444CysAsn: 0.444 ± 0.01	0.725CysPro: 0.725 ± 0.014	0.447CysGln: 0.447 ± 0.01	0.699CysArg: 0.699 ± 0.011	0.986CysSer: 0.986 ± 0.016	0.791CysThr: 0.791 ± 0.012	0.886CysVal: 0.886 ± 0.014	0.221CysTrp: 0.221 ± 0.006	0.362CysTyr: 0.362 ± 0.008	0.0CysXaa: 0.0 ± 0.0
Asp	4.544AspAla: 4.544 ± 0.034	0.582AspCys: 0.582 ± 0.011	3.655AspAsp: 3.655 ± 0.033	4.142AspGlu: 4.142 ± 0.037	1.91AspPhe: 1.91 ± 0.018	3.923AspGly: 3.923 ± 0.034	1.241AspHis: 1.241 ± 0.016	2.966AspIle: 2.966 ± 0.024	2.239AspLys: 2.239 ± 0.023	4.931AspLeu: 4.931 ± 0.032	1.245AspMet: 1.245 ± 0.016	1.76AspAsn: 1.76 ± 0.016	3.436AspPro: 3.436 ± 0.026	1.824AspGln: 1.824 ± 0.022	2.92AspArg: 2.92 ± 0.027	4.147AspSer: 4.147 ± 0.031	2.992AspThr: 2.992 ± 0.026	3.542AspVal: 3.542 ± 0.029	0.856AspTrp: 0.856 ± 0.012	1.531AspTyr: 1.531 ± 0.019	0.0AspXaa: 0.0 ± 0.0
Glu	4.784GluAla: 4.784 ± 0.033	0.707GluCys: 0.707 ± 0.013	3.708GluAsp: 3.708 ± 0.034	4.65GluGlu: 4.65 ± 0.051	1.878GluPhe: 1.878 ± 0.019	3.542GluGly: 3.542 ± 0.03	1.53GluHis: 1.53 ± 0.017	2.81GluIle: 2.81 ± 0.025	2.951GluLys: 2.951 ± 0.032	5.586GluLeu: 5.586 ± 0.038	1.279GluMet: 1.279 ± 0.016	1.892GluAsn: 1.892 ± 0.02	3.023GluPro: 3.023 ± 0.033	2.317GluGln: 2.317 ± 0.021	3.918GluArg: 3.918 ± 0.037	4.239GluSer: 4.239 ± 0.033	3.083GluThr: 3.083 ± 0.026	3.372GluVal: 3.372 ± 0.03	0.981GluTrp: 0.981 ± 0.013	1.69GluTyr: 1.69 ± 0.019	0.0GluXaa: 0.0 ± 0.0
Phe	2.928PheAla: 2.928 ± 0.024	0.491PheCys: 0.491 ± 0.01	2.153PheAsp: 2.153 ± 0.02	2.007PheGlu: 2.007 ± 0.02	1.358PhePhe: 1.358 ± 0.017	2.819PheGly: 2.819 ± 0.031	0.837PheHis: 0.837 ± 0.012	1.782PheIle: 1.782 ± 0.019	1.562PheLys: 1.562 ± 0.016	3.097PheLeu: 3.097 ± 0.025	0.761PheMet: 0.761 ± 0.012	1.428PheAsn: 1.428 ± 0.02	1.873PhePro: 1.873 ± 0.02	1.251PheGln: 1.251 ± 0.015	1.85PheArg: 1.85 ± 0.018	3.023PheSer: 3.023 ± 0.029	2.124PheThr: 2.124 ± 0.023	2.377PheVal: 2.377 ± 0.022	0.569PheTrp: 0.569 ± 0.012	0.98PheTyr: 0.98 ± 0.012	0.0PheXaa: 0.0 ± 0.0
Gly	5.416GlyAla: 5.416 ± 0.041	0.881GlyCys: 0.881 ± 0.015	3.413GlyAsp: 3.413 ± 0.027	3.451GlyGlu: 3.451 ± 0.03	2.472GlyPhe: 2.472 ± 0.022	5.424GlyGly: 5.424 ± 0.057	1.878GlyHis: 1.878 ± 0.024	3.293GlyIle: 3.293 ± 0.029	3.273GlyLys: 3.273 ± 0.027	5.909GlyLeu: 5.909 ± 0.039	1.572GlyMet: 1.572 ± 0.023	2.457GlyAsn: 2.457 ± 0.026	3.525GlyPro: 3.525 ± 0.03	2.488GlyGln: 2.488 ± 0.025	3.978GlyArg: 3.978 ± 0.032	6.016GlySer: 6.016 ± 0.047	4.386GlyThr: 4.386 ± 0.031	4.438GlyVal: 4.438 ± 0.03	1.126GlyTrp: 1.126 ± 0.017	2.049GlyTyr: 2.049 ± 0.022	0.0GlyXaa: 0.0 ± 0.0
His	2.14HisAla: 2.14 ± 0.022	0.317HisCys: 0.317 ± 0.007	1.317HisAsp: 1.317 ± 0.017	1.373HisGlu: 1.373 ± 0.018	0.947HisPhe: 0.947 ± 0.013	1.622HisGly: 1.622 ± 0.019	0.784HisHis: 0.784 ± 0.015	1.469HisIle: 1.469 ± 0.016	0.941HisLys: 0.941 ± 0.014	2.418HisLeu: 2.418 ± 0.022	0.527HisMet: 0.527 ± 0.01	0.861HisAsn: 0.861 ± 0.012	2.028HisPro: 2.028 ± 0.027	0.94HisGln: 0.94 ± 0.012	1.545HisArg: 1.545 ± 0.016	2.208HisSer: 2.208 ± 0.023	1.723HisThr: 1.723 ± 0.019	1.585HisVal: 1.585 ± 0.02	0.375HisTrp: 0.375 ± 0.008	0.74HisTyr: 0.74 ± 0.012	0.0HisXaa: 0.0 ± 0.0
Ile	4.287IleAla: 4.287 ± 0.03	0.722IleCys: 0.722 ± 0.012	2.882IleAsp: 2.882 ± 0.023	2.904IleGlu: 2.904 ± 0.027	1.757IlePhe: 1.757 ± 0.019	3.143IleGly: 3.143 ± 0.029	1.339IleHis: 1.339 ± 0.016	2.536IleIle: 2.536 ± 0.025	2.229IleLys: 2.229 ± 0.02	4.371IleLeu: 4.371 ± 0.036	1.001IleMet: 1.001 ± 0.016	1.807IleAsn: 1.807 ± 0.019	3.265IlePro: 3.265 ± 0.026	2.025IleGln: 2.025 ± 0.02	2.989IleArg: 2.989 ± 0.029	3.956IleSer: 3.956 ± 0.029	2.948IleThr: 2.948 ± 0.021	3.304IleVal: 3.304 ± 0.027	0.812IleTrp: 0.812 ± 0.013	1.415IleTyr: 1.415 ± 0.018	0.0IleXaa: 0.0 ± 0.0
Lys	3.991LysAla: 3.991 ± 0.034	0.531LysCys: 0.531 ± 0.01	2.478LysAsp: 2.478 ± 0.024	2.893LysGlu: 2.893 ± 0.033	1.405LysPhe: 1.405 ± 0.018	2.769LysGly: 2.769 ± 0.026	1.17LysHis: 1.17 ± 0.015	2.043LysIle: 2.043 ± 0.021	2.6LysLys: 2.6 ± 0.036	4.106LysLeu: 4.106 ± 0.03	0.861LysMet: 0.861 ± 0.012	1.562LysAsn: 1.562 ± 0.019	2.708LysPro: 2.708 ± 0.026	1.713LysGln: 1.713 ± 0.019	3.225LysArg: 3.225 ± 0.031	3.441LysSer: 3.441 ± 0.026	2.559LysThr: 2.559 ± 0.022	2.666LysVal: 2.666 ± 0.028	0.643LysTrp: 0.643 ± 0.013	1.319LysTyr: 1.319 ± 0.015	0.0LysXaa: 0.0 ± 0.0
Leu	8.605LeuAla: 8.605 ± 0.054	1.273LeuCys: 1.273 ± 0.017	5.268LeuAsp: 5.268 ± 0.033	5.475LeuGlu: 5.475 ± 0.038	3.23LeuPhe: 3.23 ± 0.03	6.357LeuGly: 6.357 ± 0.041	2.376LeuHis: 2.376 ± 0.021	3.964LeuIle: 3.964 ± 0.031	4.105LeuLys: 4.105 ± 0.033	8.143LeuLeu: 8.143 ± 0.057	1.719LeuMet: 1.719 ± 0.018	3.25LeuAsn: 3.25 ± 0.023	5.843LeuPro: 5.843 ± 0.035	3.426LeuGln: 3.426 ± 0.028	5.676LeuArg: 5.676 ± 0.043	7.568LeuSer: 7.568 ± 0.044	5.139LeuThr: 5.139 ± 0.032	6.022LeuVal: 6.022 ± 0.044	1.256LeuTrp: 1.256 ± 0.017	2.328LeuTyr: 2.328 ± 0.021	0.0LeuXaa: 0.0 ± 0.0
Met	1.849MetAla: 1.849 ± 0.018	0.254MetCys: 0.254 ± 0.008	1.169MetAsp: 1.169 ± 0.015	1.166MetGlu: 1.166 ± 0.016	0.76MetPhe: 0.76 ± 0.012	1.346MetGly: 1.346 ± 0.022	0.541MetHis: 0.541 ± 0.009	0.995MetIle: 0.995 ± 0.013	0.896MetLys: 0.896 ± 0.012	1.902MetLeu: 1.902 ± 0.019	0.503MetMet: 0.503 ± 0.012	0.824MetAsn: 0.824 ± 0.013	1.208MetPro: 1.208 ± 0.017	0.755MetGln: 0.755 ± 0.011	1.311MetArg: 1.311 ± 0.013	2.02MetSer: 2.02 ± 0.024	1.24MetThr: 1.24 ± 0.014	1.283MetVal: 1.283 ± 0.016	0.295MetTrp: 0.295 ± 0.008	0.518MetTyr: 0.518 ± 0.01	0.0MetXaa: 0.0 ± 0.0
Asn	3.123AsnAla: 3.123 ± 0.024	0.42AsnCys: 0.42 ± 0.009	1.834AsnAsp: 1.834 ± 0.022	1.927AsnGlu: 1.927 ± 0.018	1.177AsnPhe: 1.177 ± 0.015	2.707AsnGly: 2.707 ± 0.028	0.87AsnHis: 0.87 ± 0.011	2.0AsnIle: 2.0 ± 0.019	1.542AsnLys: 1.542 ± 0.017	3.289AsnLeu: 3.289 ± 0.027	0.8AsnMet: 0.8 ± 0.012	1.472AsnAsn: 1.472 ± 0.018	2.566AsnPro: 2.566 ± 0.022	1.337AsnGln: 1.337 ± 0.016	1.867AsnArg: 1.867 ± 0.021	2.847AsnSer: 2.847 ± 0.023	2.338AsnThr: 2.338 ± 0.021	2.337AsnVal: 2.337 ± 0.021	0.55AsnTrp: 0.55 ± 0.011	1.045AsnTyr: 1.045 ± 0.014	0.0AsnXaa: 0.0 ± 0.0
Pro	5.551ProAla: 5.551 ± 0.053	0.528ProCys: 0.528 ± 0.012	3.598ProAsp: 3.598 ± 0.034	3.91ProGlu: 3.91 ± 0.029	2.042ProPhe: 2.042 ± 0.022	4.217ProGly: 4.217 ± 0.038	1.617ProHis: 1.617 ± 0.02	2.953ProIle: 2.953 ± 0.026	2.69ProLys: 2.69 ± 0.026	5.167ProLeu: 5.167 ± 0.036	1.104ProMet: 1.104 ± 0.015	2.517ProAsn: 2.517 ± 0.021	6.06ProPro: 6.06 ± 0.085	2.33ProGln: 2.33 ± 0.03	3.727ProArg: 3.727 ± 0.036	6.545ProSer: 6.545 ± 0.052	4.84ProThr: 4.84 ± 0.042	4.025ProVal: 4.025 ± 0.033	0.685ProTrp: 0.685 ± 0.012	1.578ProTyr: 1.578 ± 0.019	0.0ProXaa: 0.0 ± 0.0
Gln	3.428GlnAla: 3.428 ± 0.029	0.456GlnCys: 0.456 ± 0.009	1.878GlnAsp: 1.878 ± 0.019	2.063GlnGlu: 2.063 ± 0.022	1.288GlnPhe: 1.288 ± 0.015	2.219GlnGly: 2.219 ± 0.023	1.049GlnHis: 1.049 ± 0.016	1.827GlnIle: 1.827 ± 0.018	1.537GlnLys: 1.537 ± 0.019	3.748GlnLeu: 3.748 ± 0.029	0.797GlnMet: 0.797 ± 0.012	1.343GlnAsn: 1.343 ± 0.018	2.564GlnPro: 2.564 ± 0.034	1.836GlnGln: 1.836 ± 0.038	2.445GlnArg: 2.445 ± 0.023	3.07GlnSer: 3.07 ± 0.024	2.376GlnThr: 2.376 ± 0.024	2.366GlnVal: 2.366 ± 0.024	0.546GlnTrp: 0.546 ± 0.009	1.108GlnTyr: 1.108 ± 0.017	0.0GlnXaa: 0.0 ± 0.0
Arg	5.381ArgAla: 5.381 ± 0.033	0.782ArgCys: 0.782 ± 0.013	3.111ArgAsp: 3.111 ± 0.029	3.602ArgGlu: 3.602 ± 0.033	2.184ArgPhe: 2.184 ± 0.026	3.626ArgGly: 3.626 ± 0.031	1.546ArgHis: 1.546 ± 0.02	3.104ArgIle: 3.104 ± 0.025	2.99ArgLys: 2.99 ± 0.027	5.708ArgLeu: 5.708 ± 0.033	1.357ArgMet: 1.357 ± 0.015	2.095ArgAsn: 2.095 ± 0.02	3.768ArgPro: 3.768 ± 0.036	2.303ArgGln: 2.303 ± 0.022	4.745ArgArg: 4.745 ± 0.042	5.09ArgSer: 5.09 ± 0.046	3.622ArgThr: 3.622 ± 0.029	3.836ArgVal: 3.836 ± 0.026	0.941ArgTrp: 0.941 ± 0.011	1.689ArgTyr: 1.689 ± 0.02	0.0ArgXaa: 0.0 ± 0.0
Ser	6.822SerAla: 6.822 ± 0.043	0.918SerCys: 0.918 ± 0.016	4.361SerAsp: 4.361 ± 0.029	4.201SerGlu: 4.201 ± 0.034	2.927SerPhe: 2.927 ± 0.025	5.9SerGly: 5.9 ± 0.04	2.227SerHis: 2.227 ± 0.026	4.196SerIle: 4.196 ± 0.03	3.558SerLys: 3.558 ± 0.03	7.444SerLeu: 7.444 ± 0.044	1.693SerMet: 1.693 ± 0.018	3.131SerAsn: 3.131 ± 0.025	6.282SerPro: 6.282 ± 0.063	3.236SerGln: 3.236 ± 0.024	5.314SerArg: 5.314 ± 0.043	8.847SerSer: 8.847 ± 0.068	6.131SerThr: 6.131 ± 0.044	5.126SerVal: 5.126 ± 0.036	1.047SerTrp: 1.047 ± 0.015	2.186SerTyr: 2.186 ± 0.024	0.0SerXaa: 0.0 ± 0.0
Thr	4.919ThrAla: 4.919 ± 0.037	0.795ThrCys: 0.795 ± 0.013	2.802ThrAsp: 2.802 ± 0.022	2.998ThrGlu: 2.998 ± 0.025	2.24ThrPhe: 2.24 ± 0.022	4.428ThrGly: 4.428 ± 0.037	1.635ThrHis: 1.635 ± 0.02	3.304ThrIle: 3.304 ± 0.026	2.543ThrLys: 2.543 ± 0.023	5.778ThrLeu: 5.778 ± 0.038	1.2ThrMet: 1.2 ± 0.013	2.254ThrAsn: 2.254 ± 0.021	5.066ThrPro: 5.066 ± 0.045	2.24ThrGln: 2.24 ± 0.023	3.769ThrArg: 3.769 ± 0.028	5.712ThrSer: 5.712 ± 0.04	4.459ThrThr: 4.459 ± 0.041	3.711ThrVal: 3.711 ± 0.029	0.894ThrTrp: 0.894 ± 0.013	1.708ThrTyr: 1.708 ± 0.021	0.0ThrXaa: 0.0 ± 0.0
Val	5.474ValAla: 5.474 ± 0.032	0.879ValCys: 0.879 ± 0.015	3.568ValAsp: 3.568 ± 0.025	3.672ValGlu: 3.672 ± 0.032	2.39ValPhe: 2.39 ± 0.024	3.982ValGly: 3.982 ± 0.03	1.623ValHis: 1.623 ± 0.018	3.144ValIle: 3.144 ± 0.025	2.83ValLys: 2.83 ± 0.028	5.942ValLeu: 5.942 ± 0.038	1.276ValMet: 1.276 ± 0.015	2.201ValAsn: 2.201 ± 0.02	4.031ValPro: 4.031 ± 0.034	2.457ValGln: 2.457 ± 0.021	3.606ValArg: 3.606 ± 0.027	4.954ValSer: 4.954 ± 0.034	3.61ValThr: 3.61 ± 0.026	4.533ValVal: 4.533 ± 0.033	1.064ValTrp: 1.064 ± 0.016	1.842ValTyr: 1.842 ± 0.019	0.0ValXaa: 0.0 ± 0.0
Trp	1.155TrpAla: 1.155 ± 0.014	0.221TrpCys: 0.221 ± 0.006	1.071TrpAsp: 1.071 ± 0.015	0.823TrpGlu: 0.823 ± 0.014	0.558TrpPhe: 0.558 ± 0.01	0.927TrpGly: 0.927 ± 0.015	0.357TrpHis: 0.357 ± 0.008	0.779TrpIle: 0.779 ± 0.011	0.752TrpLys: 0.752 ± 0.013	1.288TrpLeu: 1.288 ± 0.017	0.409TrpMet: 0.409 ± 0.01	0.68TrpAsn: 0.68 ± 0.013	0.602TrpPro: 0.602 ± 0.012	0.466TrpGln: 0.466 ± 0.01	0.925TrpArg: 0.925 ± 0.015	1.179TrpSer: 1.179 ± 0.014	0.934TrpThr: 0.934 ± 0.014	0.958TrpVal: 0.958 ± 0.014	0.267TrpTrp: 0.267 ± 0.007	0.406TrpTyr: 0.406 ± 0.01	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.289TyrAla: 2.289 ± 0.021	0.379TyrCys: 0.379 ± 0.009	1.65TyrAsp: 1.65 ± 0.017	1.491TyrGlu: 1.491 ± 0.017	1.099TyrPhe: 1.099 ± 0.015	1.913TyrGly: 1.913 ± 0.022	0.727TyrHis: 0.727 ± 0.01	1.472TyrIle: 1.472 ± 0.016	1.089TyrLys: 1.089 ± 0.015	2.589TyrLeu: 2.589 ± 0.023	0.616TyrMet: 0.616 ± 0.012	1.124TyrAsn: 1.124 ± 0.015	1.585TyrPro: 1.585 ± 0.019	1.099TyrGln: 1.099 ± 0.015	1.583TyrArg: 1.583 ± 0.02	2.211TyrSer: 2.211 ± 0.023	1.744TyrThr: 1.744 ± 0.02	1.702TyrVal: 1.702 ± 0.017	0.458TyrTrp: 0.458 ± 0.01	0.879TyrTyr: 0.879 ± 0.014	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 10990 proteins (5600857 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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