Amino acid dipepetide frequency for Mahella australiensis (strain DSM 15567 / CIP 107919 / 50-1 BON)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	7.806AlaAla: 7.806 ± 0.13	0.93AlaCys: 0.93 ± 0.03	5.253AlaAsp: 5.253 ± 0.084	4.604AlaGlu: 4.604 ± 0.088	3.122AlaPhe: 3.122 ± 0.061	6.182AlaGly: 6.182 ± 0.1	1.317AlaHis: 1.317 ± 0.042	6.794AlaIle: 6.794 ± 0.097	4.612AlaLys: 4.612 ± 0.074	7.863AlaLeu: 7.863 ± 0.108	2.752AlaMet: 2.752 ± 0.054	2.772AlaAsn: 2.772 ± 0.064	2.24AlaPro: 2.24 ± 0.055	2.884AlaGln: 2.884 ± 0.058	3.502AlaArg: 3.502 ± 0.067	4.239AlaSer: 4.239 ± 0.078	3.413AlaThr: 3.413 ± 0.077	6.888AlaVal: 6.888 ± 0.107	0.819AlaTrp: 0.819 ± 0.034	2.929AlaTyr: 2.929 ± 0.061	0.0AlaXaa: 0.0 ± 0.0
Cys	0.731CysAla: 0.731 ± 0.031	0.169CysCys: 0.169 ± 0.015	0.751CysAsp: 0.751 ± 0.033	0.506CysGlu: 0.506 ± 0.024	0.368CysPhe: 0.368 ± 0.02	1.155CysGly: 1.155 ± 0.037	0.271CysHis: 0.271 ± 0.017	0.896CysIle: 0.896 ± 0.028	0.553CysLys: 0.553 ± 0.024	0.8CysLeu: 0.8 ± 0.031	0.338CysMet: 0.338 ± 0.022	0.399CysAsn: 0.399 ± 0.022	0.544CysPro: 0.544 ± 0.026	0.343CysGln: 0.343 ± 0.018	0.638CysArg: 0.638 ± 0.027	0.683CysSer: 0.683 ± 0.028	0.485CysThr: 0.485 ± 0.024	0.656CysVal: 0.656 ± 0.032	0.12CysTrp: 0.12 ± 0.012	0.445CysTyr: 0.445 ± 0.019	0.0CysXaa: 0.0 ± 0.0
Asp	4.829AspAla: 4.829 ± 0.081	0.554AspCys: 0.554 ± 0.027	4.044AspAsp: 4.044 ± 0.086	4.697AspGlu: 4.697 ± 0.074	2.479AspPhe: 2.479 ± 0.048	4.735AspGly: 4.735 ± 0.089	0.777AspHis: 0.777 ± 0.028	6.974AspIle: 6.974 ± 0.11	4.635AspLys: 4.635 ± 0.082	4.44AspLeu: 4.44 ± 0.069	2.335AspMet: 2.335 ± 0.053	2.919AspAsn: 2.919 ± 0.052	2.36AspPro: 2.36 ± 0.057	1.516AspGln: 1.516 ± 0.047	2.78AspArg: 2.78 ± 0.059	2.859AspSer: 2.859 ± 0.062	3.09AspThr: 3.09 ± 0.059	4.792AspVal: 4.792 ± 0.076	0.734AspTrp: 0.734 ± 0.032	2.626AspTyr: 2.626 ± 0.06	0.0AspXaa: 0.0 ± 0.0
Glu	5.138GluAla: 5.138 ± 0.074	0.573GluCys: 0.573 ± 0.027	3.559GluAsp: 3.559 ± 0.064	4.274GluGlu: 4.274 ± 0.083	2.22GluPhe: 2.22 ± 0.058	3.989GluGly: 3.989 ± 0.07	1.284GluHis: 1.284 ± 0.033	4.919GluIle: 4.919 ± 0.084	3.593GluLys: 3.593 ± 0.073	5.838GluLeu: 5.838 ± 0.07	1.936GluMet: 1.936 ± 0.04	2.802GluAsn: 2.802 ± 0.058	2.132GluPro: 2.132 ± 0.049	2.991GluGln: 2.991 ± 0.062	3.509GluArg: 3.509 ± 0.071	2.737GluSer: 2.737 ± 0.051	2.662GluThr: 2.662 ± 0.061	4.124GluVal: 4.124 ± 0.073	0.697GluTrp: 0.697 ± 0.037	2.57GluTyr: 2.57 ± 0.058	0.0GluXaa: 0.0 ± 0.0
Phe	2.76PheAla: 2.76 ± 0.046	0.437PheCys: 0.437 ± 0.021	2.64PheAsp: 2.64 ± 0.059	2.218PheGlu: 2.218 ± 0.051	1.535PhePhe: 1.535 ± 0.045	2.788PheGly: 2.788 ± 0.06	0.607PheHis: 0.607 ± 0.028	3.467PheIle: 3.467 ± 0.076	2.267PheLys: 2.267 ± 0.053	2.934PheLeu: 2.934 ± 0.068	1.284PheMet: 1.284 ± 0.043	1.905PheAsn: 1.905 ± 0.044	1.335PhePro: 1.335 ± 0.04	0.982PheGln: 0.982 ± 0.034	1.466PheArg: 1.466 ± 0.036	2.366PheSer: 2.366 ± 0.059	2.144PheThr: 2.144 ± 0.052	2.574PheVal: 2.574 ± 0.051	0.452PheTrp: 0.452 ± 0.023	1.573PheTyr: 1.573 ± 0.043	0.0PheXaa: 0.0 ± 0.0
Gly	5.051GlyAla: 5.051 ± 0.102	0.991GlyCys: 0.991 ± 0.039	4.024GlyAsp: 4.024 ± 0.081	3.719GlyGlu: 3.719 ± 0.067	3.006GlyPhe: 3.006 ± 0.061	5.022GlyGly: 5.022 ± 0.092	1.351GlyHis: 1.351 ± 0.037	6.917GlyIle: 6.917 ± 0.099	4.475GlyLys: 4.475 ± 0.077	6.433GlyLeu: 6.433 ± 0.088	2.434GlyMet: 2.434 ± 0.056	3.086GlyAsn: 3.086 ± 0.07	1.975GlyPro: 1.975 ± 0.05	2.6GlyGln: 2.6 ± 0.06	3.511GlyArg: 3.511 ± 0.061	3.831GlySer: 3.831 ± 0.087	3.756GlyThr: 3.756 ± 0.073	5.019GlyVal: 5.019 ± 0.076	0.92GlyTrp: 0.92 ± 0.032	3.437GlyTyr: 3.437 ± 0.069	0.0GlyXaa: 0.0 ± 0.0
His	1.173HisAla: 1.173 ± 0.035	0.255HisCys: 0.255 ± 0.015	0.986HisAsp: 0.986 ± 0.035	0.956HisGlu: 0.956 ± 0.031	0.726HisPhe: 0.726 ± 0.029	1.324HisGly: 1.324 ± 0.042	0.381HisHis: 0.381 ± 0.025	1.701HisIle: 1.701 ± 0.039	0.956HisLys: 0.956 ± 0.031	1.392HisLeu: 1.392 ± 0.039	0.599HisMet: 0.599 ± 0.023	0.737HisAsn: 0.737 ± 0.029	0.944HisPro: 0.944 ± 0.031	0.466HisGln: 0.466 ± 0.025	0.817HisArg: 0.817 ± 0.028	0.934HisSer: 0.934 ± 0.036	0.862HisThr: 0.862 ± 0.03	1.135HisVal: 1.135 ± 0.036	0.234HisTrp: 0.234 ± 0.017	0.732HisTyr: 0.732 ± 0.029	0.0HisXaa: 0.0 ± 0.0
Ile	7.156IleAla: 7.156 ± 0.106	0.972IleCys: 0.972 ± 0.033	5.835IleAsp: 5.835 ± 0.087	5.55IleGlu: 5.55 ± 0.08	2.986IlePhe: 2.986 ± 0.067	5.793IleGly: 5.793 ± 0.087	1.197IleHis: 1.197 ± 0.036	7.182IleIle: 7.182 ± 0.111	5.594IleLys: 5.594 ± 0.087	6.917IleLeu: 6.917 ± 0.107	2.614IleMet: 2.614 ± 0.054	4.103IleAsn: 4.103 ± 0.075	3.624IlePro: 3.624 ± 0.069	2.075IleGln: 2.075 ± 0.053	3.458IleArg: 3.458 ± 0.067	5.622IleSer: 5.622 ± 0.094	4.479IleThr: 4.479 ± 0.076	5.345IleVal: 5.345 ± 0.085	0.894IleTrp: 0.894 ± 0.034	3.186IleTyr: 3.186 ± 0.067	0.0IleXaa: 0.0 ± 0.0
Lys	5.62LysAla: 5.62 ± 0.084	0.499LysCys: 0.499 ± 0.025	4.086LysAsp: 4.086 ± 0.071	4.637LysGlu: 4.637 ± 0.081	1.511LysPhe: 1.511 ± 0.04	4.162LysGly: 4.162 ± 0.072	1.059LysHis: 1.059 ± 0.033	4.162LysIle: 4.162 ± 0.072	3.74LysLys: 3.74 ± 0.084	5.126LysLeu: 5.126 ± 0.078	1.664LysMet: 1.664 ± 0.038	2.846LysAsn: 2.846 ± 0.055	2.55LysPro: 2.55 ± 0.056	2.505LysGln: 2.505 ± 0.05	3.138LysArg: 3.138 ± 0.058	3.039LysSer: 3.039 ± 0.057	2.968LysThr: 2.968 ± 0.064	4.081LysVal: 4.081 ± 0.068	0.671LysTrp: 0.671 ± 0.027	2.563LysTyr: 2.563 ± 0.051	0.0LysXaa: 0.0 ± 0.0
Leu	7.109LeuAla: 7.109 ± 0.113	1.062LeuCys: 1.062 ± 0.033	5.533LeuAsp: 5.533 ± 0.077	5.293LeuGlu: 5.293 ± 0.073	3.396LeuPhe: 3.396 ± 0.074	5.867LeuGly: 5.867 ± 0.085	1.502LeuHis: 1.502 ± 0.041	6.698LeuIle: 6.698 ± 0.113	5.933LeuLys: 5.933 ± 0.075	8.095LeuLeu: 8.095 ± 0.119	2.693LeuMet: 2.693 ± 0.056	4.066LeuAsn: 4.066 ± 0.066	4.015LeuPro: 4.015 ± 0.059	2.694LeuGln: 2.694 ± 0.05	3.732LeuArg: 3.732 ± 0.071	6.104LeuSer: 6.104 ± 0.087	4.426LeuThr: 4.426 ± 0.073	5.252LeuVal: 5.252 ± 0.083	0.965LeuTrp: 0.965 ± 0.034	3.387LeuTyr: 3.387 ± 0.065	0.0LeuXaa: 0.0 ± 0.0
Met	3.025MetAla: 3.025 ± 0.072	0.26MetCys: 0.26 ± 0.019	2.185MetAsp: 2.185 ± 0.051	1.918MetGlu: 1.918 ± 0.049	0.922MetPhe: 0.922 ± 0.032	2.254MetGly: 2.254 ± 0.046	0.567MetHis: 0.567 ± 0.024	2.215MetIle: 2.215 ± 0.055	1.723MetLys: 1.723 ± 0.041	3.144MetLeu: 3.144 ± 0.061	0.925MetMet: 0.925 ± 0.036	1.331MetAsn: 1.331 ± 0.034	1.663MetPro: 1.663 ± 0.045	1.106MetGln: 1.106 ± 0.035	1.645MetArg: 1.645 ± 0.041	1.866MetSer: 1.866 ± 0.047	1.499MetThr: 1.499 ± 0.04	2.168MetVal: 2.168 ± 0.052	0.262MetTrp: 0.262 ± 0.017	0.896MetTyr: 0.896 ± 0.029	0.0MetXaa: 0.0 ± 0.0
Asn	3.498AsnAla: 3.498 ± 0.071	0.414AsnCys: 0.414 ± 0.022	2.851AsnAsp: 2.851 ± 0.055	2.607AsnGlu: 2.607 ± 0.052	1.526AsnPhe: 1.526 ± 0.04	3.544AsnGly: 3.544 ± 0.066	0.629AsnHis: 0.629 ± 0.024	4.536AsnIle: 4.536 ± 0.079	2.742AsnLys: 2.742 ± 0.052	3.139AsnLeu: 3.139 ± 0.069	1.437AsnMet: 1.437 ± 0.039	2.116AsnAsn: 2.116 ± 0.057	2.097AsnPro: 2.097 ± 0.049	1.187AsnGln: 1.187 ± 0.037	1.949AsnArg: 1.949 ± 0.048	2.323AsnSer: 2.323 ± 0.059	2.301AsnThr: 2.301 ± 0.059	3.074AsnVal: 3.074 ± 0.065	0.466AsnTrp: 0.466 ± 0.025	1.765AsnTyr: 1.765 ± 0.047	0.0AsnXaa: 0.0 ± 0.0
Pro	2.967ProAla: 2.967 ± 0.063	0.36ProCys: 0.36 ± 0.02	3.015ProAsp: 3.015 ± 0.062	2.787ProGlu: 2.787 ± 0.061	1.679ProPhe: 1.679 ± 0.043	2.729ProGly: 2.729 ± 0.055	0.826ProHis: 0.826 ± 0.028	2.964ProIle: 2.964 ± 0.056	1.954ProLys: 1.954 ± 0.052	3.524ProLeu: 3.524 ± 0.06	1.066ProMet: 1.066 ± 0.036	1.608ProAsn: 1.608 ± 0.045	1.475ProPro: 1.475 ± 0.049	1.425ProGln: 1.425 ± 0.035	1.424ProArg: 1.424 ± 0.046	2.3ProSer: 2.3 ± 0.062	1.938ProThr: 1.938 ± 0.055	3.258ProVal: 3.258 ± 0.06	0.514ProTrp: 0.514 ± 0.023	1.762ProTyr: 1.762 ± 0.044	0.0ProXaa: 0.0 ± 0.0
Gln	2.902GlnAla: 2.902 ± 0.054	0.402GlnCys: 0.402 ± 0.024	1.742GlnAsp: 1.742 ± 0.042	1.947GlnGlu: 1.947 ± 0.05	1.109GlnPhe: 1.109 ± 0.034	1.938GlnGly: 1.938 ± 0.049	0.67GlnHis: 0.67 ± 0.029	2.268GlnIle: 2.268 ± 0.057	2.216GlnLys: 2.216 ± 0.052	3.153GlnLeu: 3.153 ± 0.059	1.094GlnMet: 1.094 ± 0.035	1.482GlnAsn: 1.482 ± 0.046	1.553GlnPro: 1.553 ± 0.041	1.862GlnGln: 1.862 ± 0.053	2.085GlnArg: 2.085 ± 0.054	1.78GlnSer: 1.78 ± 0.046	1.505GlnThr: 1.505 ± 0.048	1.953GlnVal: 1.953 ± 0.047	0.538GlnTrp: 0.538 ± 0.022	1.526GlnTyr: 1.526 ± 0.044	0.0GlnXaa: 0.0 ± 0.0
Arg	3.132ArgAla: 3.132 ± 0.057	0.585ArgCys: 0.585 ± 0.027	2.559ArgAsp: 2.559 ± 0.053	2.789ArgGlu: 2.789 ± 0.062	2.011ArgPhe: 2.011 ± 0.051	2.756ArgGly: 2.756 ± 0.055	0.928ArgHis: 0.928 ± 0.029	3.951ArgIle: 3.951 ± 0.067	2.481ArgLys: 2.481 ± 0.052	4.715ArgLeu: 4.715 ± 0.082	1.582ArgMet: 1.582 ± 0.044	2.046ArgAsn: 2.046 ± 0.046	1.658ArgPro: 1.658 ± 0.046	2.029ArgGln: 2.029 ± 0.051	2.647ArgArg: 2.647 ± 0.067	2.344ArgSer: 2.344 ± 0.047	2.039ArgThr: 2.039 ± 0.045	2.87ArgVal: 2.87 ± 0.059	0.686ArgTrp: 0.686 ± 0.028	2.332ArgTyr: 2.332 ± 0.052	0.0ArgXaa: 0.0 ± 0.0
Ser	4.38SerAla: 4.38 ± 0.071	0.613SerCys: 0.613 ± 0.027	3.811SerAsp: 3.811 ± 0.065	3.011SerGlu: 3.011 ± 0.056	2.402SerPhe: 2.402 ± 0.051	4.721SerGly: 4.721 ± 0.099	0.984SerHis: 0.984 ± 0.03	4.92SerIle: 4.92 ± 0.085	3.054SerLys: 3.054 ± 0.066	4.871SerLeu: 4.871 ± 0.072	1.817SerMet: 1.817 ± 0.047	2.332SerAsn: 2.332 ± 0.059	2.129SerPro: 2.129 ± 0.052	1.933SerGln: 1.933 ± 0.047	2.613SerArg: 2.613 ± 0.06	3.624SerSer: 3.624 ± 0.074	2.714SerThr: 2.714 ± 0.056	3.968SerVal: 3.968 ± 0.068	0.711SerTrp: 0.711 ± 0.032	2.222SerTyr: 2.222 ± 0.052	0.0SerXaa: 0.0 ± 0.0
Thr	4.461ThrAla: 4.461 ± 0.085	0.419ThrCys: 0.419 ± 0.02	3.179ThrAsp: 3.179 ± 0.053	2.603ThrGlu: 2.603 ± 0.054	1.843ThrPhe: 1.843 ± 0.049	4.272ThrGly: 4.272 ± 0.076	0.843ThrHis: 0.843 ± 0.028	3.985ThrIle: 3.985 ± 0.074	2.242ThrLys: 2.242 ± 0.051	4.364ThrLeu: 4.364 ± 0.082	1.315ThrMet: 1.315 ± 0.036	1.745ThrAsn: 1.745 ± 0.049	2.258ThrPro: 2.258 ± 0.06	1.396ThrGln: 1.396 ± 0.038	1.776ThrArg: 1.776 ± 0.045	2.809ThrSer: 2.809 ± 0.063	2.409ThrThr: 2.409 ± 0.072	4.378ThrVal: 4.378 ± 0.081	0.559ThrTrp: 0.559 ± 0.03	1.858ThrTyr: 1.858 ± 0.048	0.0ThrXaa: 0.0 ± 0.0
Val	5.447ValAla: 5.447 ± 0.078	0.766ValCys: 0.766 ± 0.03	4.547ValAsp: 4.547 ± 0.075	4.364ValGlu: 4.364 ± 0.078	2.669ValPhe: 2.669 ± 0.048	4.458ValGly: 4.458 ± 0.076	1.139ValHis: 1.139 ± 0.037	5.752ValIle: 5.752 ± 0.089	4.529ValLys: 4.529 ± 0.068	6.72ValLeu: 6.72 ± 0.082	2.058ValMet: 2.058 ± 0.051	3.074ValAsn: 3.074 ± 0.057	2.864ValPro: 2.864 ± 0.052	1.981ValGln: 1.981 ± 0.042	2.902ValArg: 2.902 ± 0.061	4.496ValSer: 4.496 ± 0.08	3.486ValThr: 3.486 ± 0.081	4.973ValVal: 4.973 ± 0.08	0.723ValTrp: 0.723 ± 0.028	2.749ValTyr: 2.749 ± 0.055	0.0ValXaa: 0.0 ± 0.0
Trp	0.837TrpAla: 0.837 ± 0.033	0.12TrpCys: 0.12 ± 0.012	0.793TrpAsp: 0.793 ± 0.034	0.652TrpGlu: 0.652 ± 0.032	0.497TrpPhe: 0.497 ± 0.024	0.819TrpGly: 0.819 ± 0.036	0.285TrpHis: 0.285 ± 0.017	0.73TrpIle: 0.73 ± 0.029	0.583TrpLys: 0.583 ± 0.027	1.114TrpLeu: 1.114 ± 0.035	0.385TrpMet: 0.385 ± 0.02	0.665TrpAsn: 0.665 ± 0.035	0.471TrpPro: 0.471 ± 0.026	0.56TrpGln: 0.56 ± 0.027	0.594TrpArg: 0.594 ± 0.029	0.627TrpSer: 0.627 ± 0.03	0.493TrpThr: 0.493 ± 0.021	0.731TrpVal: 0.731 ± 0.032	0.223TrpTrp: 0.223 ± 0.016	0.482TrpTyr: 0.482 ± 0.023	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.899TyrAla: 2.899 ± 0.063	0.469TyrCys: 0.469 ± 0.026	2.782TyrAsp: 2.782 ± 0.057	2.418TyrGlu: 2.418 ± 0.048	1.725TyrPhe: 1.725 ± 0.043	3.048TyrGly: 3.048 ± 0.061	0.694TyrHis: 0.694 ± 0.026	3.553TyrIle: 3.553 ± 0.075	2.745TyrLys: 2.745 ± 0.062	3.239TyrLeu: 3.239 ± 0.067	1.243TyrMet: 1.243 ± 0.035	2.17TyrAsn: 2.17 ± 0.044	1.688TyrPro: 1.688 ± 0.047	1.191TyrGln: 1.191 ± 0.04	1.955TyrArg: 1.955 ± 0.054	2.244TyrSer: 2.244 ± 0.052	2.046TyrThr: 2.046 ± 0.049	2.459TyrVal: 2.459 ± 0.061	0.473TyrTrp: 0.473 ± 0.023	1.717TyrTyr: 1.717 ± 0.05	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2858 proteins (929707 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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