Amino acid dipepetide frequency for Cryptosporidium muris (strain RN66)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	1.915AlaAla: 1.915 ± 0.047	0.697AlaCys: 0.697 ± 0.02	1.562AlaAsp: 1.562 ± 0.032	1.938AlaGlu: 1.938 ± 0.034	1.473AlaPhe: 1.473 ± 0.03	1.423AlaGly: 1.423 ± 0.032	0.647AlaHis: 0.647 ± 0.017	3.4AlaIle: 3.4 ± 0.043	2.294AlaLys: 2.294 ± 0.037	3.912AlaLeu: 3.912 ± 0.047	0.738AlaMet: 0.738 ± 0.02	2.123AlaAsn: 2.123 ± 0.033	1.176AlaPro: 1.176 ± 0.03	1.163AlaGln: 1.163 ± 0.023	1.489AlaArg: 1.489 ± 0.031	3.05AlaSer: 3.05 ± 0.045	2.053AlaThr: 2.053 ± 0.038	1.818AlaVal: 1.818 ± 0.04	0.313AlaTrp: 0.313 ± 0.011	1.287AlaTyr: 1.287 ± 0.023	0.0AlaXaa: 0.0 ± 0.0
Cys	0.556CysAla: 0.556 ± 0.016	0.494CysCys: 0.494 ± 0.016	0.968CysAsp: 0.968 ± 0.021	1.081CysGlu: 1.081 ± 0.023	0.861CysPhe: 0.861 ± 0.02	0.998CysGly: 0.998 ± 0.024	0.392CysHis: 0.392 ± 0.013	2.237CysIle: 2.237 ± 0.039	1.458CysLys: 1.458 ± 0.028	1.934CysLeu: 1.934 ± 0.032	0.384CysMet: 0.384 ± 0.012	1.631CysAsn: 1.631 ± 0.031	0.818CysPro: 0.818 ± 0.037	0.57CysGln: 0.57 ± 0.014	0.868CysArg: 0.868 ± 0.022	1.778CysSer: 1.778 ± 0.035	1.098CysThr: 1.098 ± 0.024	0.805CysVal: 0.805 ± 0.02	0.19CysTrp: 0.19 ± 0.008	0.736CysTyr: 0.736 ± 0.018	0.0CysXaa: 0.0 ± 0.0
Asp	1.577AspAla: 1.577 ± 0.036	0.873AspCys: 0.873 ± 0.019	3.046AspAsp: 3.046 ± 0.058	3.841AspGlu: 3.841 ± 0.057	2.468AspPhe: 2.468 ± 0.034	2.045AspGly: 2.045 ± 0.04	1.012AspHis: 1.012 ± 0.02	6.923AspIle: 6.923 ± 0.063	3.952AspLys: 3.952 ± 0.04	5.166AspLeu: 5.166 ± 0.047	1.085AspMet: 1.085 ± 0.021	4.546AspAsn: 4.546 ± 0.065	1.813AspPro: 1.813 ± 0.033	1.448AspGln: 1.448 ± 0.026	1.72AspArg: 1.72 ± 0.043	4.616AspSer: 4.616 ± 0.055	2.866AspThr: 2.866 ± 0.036	2.22AspVal: 2.22 ± 0.039	0.497AspTrp: 0.497 ± 0.017	2.219AspTyr: 2.219 ± 0.035	0.0AspXaa: 0.0 ± 0.0
Glu	2.242GluAla: 2.242 ± 0.038	1.098GluCys: 1.098 ± 0.022	4.151GluAsp: 4.151 ± 0.057	4.479GluGlu: 4.479 ± 0.076	2.831GluPhe: 2.831 ± 0.034	2.102GluGly: 2.102 ± 0.043	1.006GluHis: 1.006 ± 0.022	5.935GluIle: 5.935 ± 0.067	4.67GluLys: 4.67 ± 0.08	6.194GluLeu: 6.194 ± 0.064	1.269GluMet: 1.269 ± 0.023	4.837GluAsn: 4.837 ± 0.057	1.401GluPro: 1.401 ± 0.028	2.069GluGln: 2.069 ± 0.039	2.29GluArg: 2.29 ± 0.052	5.142GluSer: 5.142 ± 0.055	3.081GluThr: 3.081 ± 0.048	3.303GluVal: 3.303 ± 0.041	0.668GluTrp: 0.668 ± 0.019	3.232GluTyr: 3.232 ± 0.04	0.0GluXaa: 0.0 ± 0.0
Phe	1.561PheAla: 1.561 ± 0.027	0.995PheCys: 0.995 ± 0.023	2.441PheAsp: 2.441 ± 0.037	2.741PheGlu: 2.741 ± 0.037	1.858PhePhe: 1.858 ± 0.038	2.416PheGly: 2.416 ± 0.04	0.926PheHis: 0.926 ± 0.021	4.146PheIle: 4.146 ± 0.052	2.776PheLys: 2.776 ± 0.039	4.367PheLeu: 4.367 ± 0.054	0.784PheMet: 0.784 ± 0.018	3.077PheAsn: 3.077 ± 0.041	1.747PhePro: 1.747 ± 0.031	1.624PheGln: 1.624 ± 0.023	1.681PheArg: 1.681 ± 0.026	4.103PheSer: 4.103 ± 0.049	2.219PheThr: 2.219 ± 0.038	2.221PheVal: 2.221 ± 0.035	0.529PheTrp: 0.529 ± 0.017	1.749PheTyr: 1.749 ± 0.034	0.0PheXaa: 0.0 ± 0.0
Gly	1.514GlyAla: 1.514 ± 0.037	0.8GlyCys: 0.8 ± 0.022	2.286GlyAsp: 2.286 ± 0.035	2.192GlyGlu: 2.192 ± 0.038	2.017GlyPhe: 2.017 ± 0.031	2.127GlyGly: 2.127 ± 0.054	0.852GlyHis: 0.852 ± 0.026	4.579GlyIle: 4.579 ± 0.053	2.726GlyLys: 2.726 ± 0.042	3.725GlyLeu: 3.725 ± 0.047	0.802GlyMet: 0.802 ± 0.02	3.149GlyAsn: 3.149 ± 0.042	1.162GlyPro: 1.162 ± 0.03	1.185GlyGln: 1.185 ± 0.026	1.761GlyArg: 1.761 ± 0.039	3.528GlySer: 3.528 ± 0.05	2.386GlyThr: 2.386 ± 0.043	2.145GlyVal: 2.145 ± 0.045	0.429GlyTrp: 0.429 ± 0.013	1.968GlyTyr: 1.968 ± 0.032	0.001GlyXaa: 0.001 ± 0.001
His	0.559HisAla: 0.559 ± 0.017	0.424HisCys: 0.424 ± 0.014	0.809HisAsp: 0.809 ± 0.019	1.068HisGlu: 1.068 ± 0.024	0.972HisPhe: 0.972 ± 0.021	0.85HisGly: 0.85 ± 0.024	0.534HisHis: 0.534 ± 0.046	2.015HisIle: 2.015 ± 0.032	1.273HisLys: 1.273 ± 0.025	2.024HisLeu: 2.024 ± 0.034	0.361HisMet: 0.361 ± 0.012	1.393HisAsn: 1.393 ± 0.031	0.907HisPro: 0.907 ± 0.023	0.647HisGln: 0.647 ± 0.023	0.811HisArg: 0.811 ± 0.019	1.72HisSer: 1.72 ± 0.032	0.959HisThr: 0.959 ± 0.025	0.749HisVal: 0.749 ± 0.019	0.214HisTrp: 0.214 ± 0.01	0.877HisTyr: 0.877 ± 0.022	0.0HisXaa: 0.0 ± 0.0
Ile	3.45IleAla: 3.45 ± 0.049	2.079IleCys: 2.079 ± 0.036	5.267IleAsp: 5.267 ± 0.057	6.088IleGlu: 6.088 ± 0.063	4.397IlePhe: 4.397 ± 0.075	3.939IleGly: 3.939 ± 0.051	1.921IleHis: 1.921 ± 0.031	7.968IleIle: 7.968 ± 0.092	6.609IleLys: 6.609 ± 0.073	10.265IleLeu: 10.265 ± 0.092	1.625IleMet: 1.625 ± 0.028	7.237IleAsn: 7.237 ± 0.083	4.45IlePro: 4.45 ± 0.066	3.815IleGln: 3.815 ± 0.039	3.774IleArg: 3.774 ± 0.037	9.459IleSer: 9.459 ± 0.082	4.562IleThr: 4.562 ± 0.056	4.181IleVal: 4.181 ± 0.048	1.015IleTrp: 1.015 ± 0.023	4.255IleTyr: 4.255 ± 0.066	0.0IleXaa: 0.0 ± 0.0
Lys	2.343LysAla: 2.343 ± 0.039	1.405LysCys: 1.405 ± 0.027	4.346LysAsp: 4.346 ± 0.056	4.775LysGlu: 4.775 ± 0.071	3.062LysPhe: 3.062 ± 0.037	2.589LysGly: 2.589 ± 0.038	1.37LysHis: 1.37 ± 0.024	6.24LysIle: 6.24 ± 0.072	5.757LysLys: 5.757 ± 0.077	7.703LysLeu: 7.703 ± 0.071	1.333LysMet: 1.333 ± 0.023	4.986LysAsn: 4.986 ± 0.065	2.042LysPro: 2.042 ± 0.035	2.716LysGln: 2.716 ± 0.041	3.064LysArg: 3.064 ± 0.046	6.899LysSer: 6.899 ± 0.07	3.321LysThr: 3.321 ± 0.047	3.968LysVal: 3.968 ± 0.048	0.706LysTrp: 0.706 ± 0.018	4.036LysTyr: 4.036 ± 0.048	0.0LysXaa: 0.0 ± 0.0
Leu	3.98LeuAla: 3.98 ± 0.052	2.056LeuCys: 2.056 ± 0.034	5.784LeuAsp: 5.784 ± 0.059	6.456LeuGlu: 6.456 ± 0.077	4.471LeuPhe: 4.471 ± 0.059	4.164LeuGly: 4.164 ± 0.053	2.003LeuHis: 2.003 ± 0.03	7.885LeuIle: 7.885 ± 0.081	7.303LeuLys: 7.303 ± 0.069	10.588LeuLeu: 10.588 ± 0.115	1.699LeuMet: 1.699 ± 0.031	7.597LeuAsn: 7.597 ± 0.073	4.068LeuPro: 4.068 ± 0.051	4.056LeuGln: 4.056 ± 0.05	4.328LeuArg: 4.328 ± 0.049	9.38LeuSer: 9.38 ± 0.074	4.667LeuThr: 4.667 ± 0.052	4.749LeuVal: 4.749 ± 0.05	1.051LeuTrp: 1.051 ± 0.026	4.494LeuTyr: 4.494 ± 0.051	0.0LeuXaa: 0.0 ± 0.0
Met	0.87MetAla: 0.87 ± 0.021	0.322MetCys: 0.322 ± 0.011	1.162MetAsp: 1.162 ± 0.024	1.366MetGlu: 1.366 ± 0.025	0.683MetPhe: 0.683 ± 0.017	0.879MetGly: 0.879 ± 0.023	0.319MetHis: 0.319 ± 0.011	1.52MetIle: 1.52 ± 0.026	1.603MetLys: 1.603 ± 0.028	1.592MetLeu: 1.592 ± 0.03	0.397MetMet: 0.397 ± 0.011	1.611MetAsn: 1.611 ± 0.029	0.569MetPro: 0.569 ± 0.016	0.656MetGln: 0.656 ± 0.017	0.773MetArg: 0.773 ± 0.019	1.548MetSer: 1.548 ± 0.027	0.976MetThr: 0.976 ± 0.022	0.895MetVal: 0.895 ± 0.021	0.169MetTrp: 0.169 ± 0.008	0.719MetTyr: 0.719 ± 0.016	0.0MetXaa: 0.0 ± 0.0
Asn	1.777AsnAla: 1.777 ± 0.029	1.397AsnCys: 1.397 ± 0.026	3.463AsnAsp: 3.463 ± 0.052	4.857AsnGlu: 4.857 ± 0.06	3.312AsnPhe: 3.312 ± 0.042	2.715AsnGly: 2.715 ± 0.044	1.234AsnHis: 1.234 ± 0.032	9.545AsnIle: 9.545 ± 0.1	6.643AsnLys: 6.643 ± 0.072	7.463AsnLeu: 7.463 ± 0.07	1.622AsnMet: 1.622 ± 0.026	8.045AsnAsn: 8.045 ± 0.155	2.477AsnPro: 2.477 ± 0.039	2.658AsnGln: 2.658 ± 0.041	2.654AsnArg: 2.654 ± 0.038	8.252AsnSer: 8.252 ± 0.095	4.468AsnThr: 4.468 ± 0.059	2.853AsnVal: 2.853 ± 0.036	0.671AsnTrp: 0.671 ± 0.018	3.195AsnTyr: 3.195 ± 0.045	0.0AsnXaa: 0.0 ± 0.0
Pro	1.035ProAla: 1.035 ± 0.028	0.649ProCys: 0.649 ± 0.018	1.61ProAsp: 1.61 ± 0.028	2.105ProGlu: 2.105 ± 0.035	1.699ProPhe: 1.699 ± 0.03	1.392ProGly: 1.392 ± 0.036	0.695ProHis: 0.695 ± 0.019	3.629ProIle: 3.629 ± 0.05	2.563ProLys: 2.563 ± 0.048	3.883ProLeu: 3.883 ± 0.049	0.591ProMet: 0.591 ± 0.016	2.859ProAsn: 2.859 ± 0.042	1.773ProPro: 1.773 ± 0.068	1.307ProGln: 1.307 ± 0.028	1.277ProArg: 1.277 ± 0.026	3.266ProSer: 3.266 ± 0.052	2.013ProThr: 2.013 ± 0.042	1.767ProVal: 1.767 ± 0.033	0.424ProTrp: 0.424 ± 0.015	1.535ProTyr: 1.535 ± 0.029	0.0ProXaa: 0.0 ± 0.0
Gln	1.217GlnAla: 1.217 ± 0.028	0.655GlnCys: 0.655 ± 0.018	1.927GlnAsp: 1.927 ± 0.03	2.098GlnGlu: 2.098 ± 0.037	1.506GlnPhe: 1.506 ± 0.024	1.351GlnGly: 1.351 ± 0.028	0.758GlnHis: 0.758 ± 0.024	3.354GlnIle: 3.354 ± 0.04	2.545GlnLys: 2.545 ± 0.035	3.661GlnLeu: 3.661 ± 0.046	0.715GlnMet: 0.715 ± 0.018	2.792GlnAsn: 2.792 ± 0.037	1.021GlnPro: 1.021 ± 0.025	1.588GlnGln: 1.588 ± 0.041	1.551GlnArg: 1.551 ± 0.03	3.091GlnSer: 3.091 ± 0.042	1.734GlnThr: 1.734 ± 0.031	1.797GlnVal: 1.797 ± 0.032	0.417GlnTrp: 0.417 ± 0.013	1.703GlnTyr: 1.703 ± 0.029	0.0GlnXaa: 0.0 ± 0.0
Arg	1.453ArgAla: 1.453 ± 0.032	0.859ArgCys: 0.859 ± 0.02	2.138ArgAsp: 2.138 ± 0.046	2.307ArgGlu: 2.307 ± 0.035	1.762ArgPhe: 1.762 ± 0.029	1.653ArgGly: 1.653 ± 0.035	0.842ArgHis: 0.842 ± 0.022	3.57ArgIle: 3.57 ± 0.036	3.014ArgLys: 3.014 ± 0.047	3.913ArgLeu: 3.913 ± 0.048	0.734ArgMet: 0.734 ± 0.02	3.18ArgAsn: 3.18 ± 0.041	1.179ArgPro: 1.179 ± 0.024	1.532ArgGln: 1.532 ± 0.029	2.422ArgArg: 2.422 ± 0.042	3.432ArgSer: 3.432 ± 0.045	1.815ArgThr: 1.815 ± 0.037	1.889ArgVal: 1.889 ± 0.035	0.454ArgTrp: 0.454 ± 0.015	1.879ArgTyr: 1.879 ± 0.033	0.0ArgXaa: 0.0 ± 0.0
Ser	2.977SerAla: 2.977 ± 0.044	1.794SerCys: 1.794 ± 0.033	4.909SerAsp: 4.909 ± 0.063	5.645SerGlu: 5.645 ± 0.056	3.848SerPhe: 3.848 ± 0.049	3.987SerGly: 3.987 ± 0.052	1.717SerHis: 1.717 ± 0.028	9.05SerIle: 9.05 ± 0.07	6.804SerLys: 6.804 ± 0.065	9.28SerLeu: 9.28 ± 0.079	1.661SerMet: 1.661 ± 0.027	8.309SerAsn: 8.309 ± 0.087	3.331SerPro: 3.331 ± 0.06	3.202SerGln: 3.202 ± 0.039	3.464SerArg: 3.464 ± 0.05	10.058SerSer: 10.058 ± 0.113	5.382SerThr: 5.382 ± 0.061	4.056SerVal: 4.056 ± 0.052	0.803SerTrp: 0.803 ± 0.02	3.534SerTyr: 3.534 ± 0.046	0.0SerXaa: 0.0 ± 0.0
Thr	1.859ThrAla: 1.859 ± 0.037	1.084ThrCys: 1.084 ± 0.025	2.528ThrAsp: 2.528 ± 0.034	3.057ThrGlu: 3.057 ± 0.051	2.222ThrPhe: 2.222 ± 0.037	2.272ThrGly: 2.272 ± 0.044	0.936ThrHis: 0.936 ± 0.025	4.714ThrIle: 4.714 ± 0.071	3.639ThrLys: 3.639 ± 0.045	5.298ThrLeu: 5.298 ± 0.057	0.906ThrMet: 0.906 ± 0.02	4.188ThrAsn: 4.188 ± 0.044	2.223ThrPro: 2.223 ± 0.037	1.834ThrGln: 1.834 ± 0.035	1.937ThrArg: 1.937 ± 0.033	5.362ThrSer: 5.362 ± 0.06	3.517ThrThr: 3.517 ± 0.207	2.415ThrVal: 2.415 ± 0.037	0.455ThrTrp: 0.455 ± 0.015	1.851ThrTyr: 1.851 ± 0.032	0.0ThrXaa: 0.0 ± 0.0
Val	2.085ValAla: 2.085 ± 0.039	0.956ValCys: 0.956 ± 0.021	2.795ValAsp: 2.795 ± 0.039	3.005ValGlu: 3.005 ± 0.038	1.95ValPhe: 1.95 ± 0.029	2.101ValGly: 2.101 ± 0.042	0.942ValHis: 0.942 ± 0.021	4.022ValIle: 4.022 ± 0.043	3.031ValLys: 3.031 ± 0.041	4.515ValLeu: 4.515 ± 0.052	0.852ValMet: 0.852 ± 0.021	3.317ValAsn: 3.317 ± 0.038	1.916ValPro: 1.916 ± 0.031	1.578ValGln: 1.578 ± 0.03	1.83ValArg: 1.83 ± 0.029	4.056ValSer: 4.056 ± 0.048	2.538ValThr: 2.538 ± 0.038	2.445ValVal: 2.445 ± 0.046	0.45ValTrp: 0.45 ± 0.015	1.866ValTyr: 1.866 ± 0.028	0.0ValXaa: 0.0 ± 0.0
Trp	0.3TrpAla: 0.3 ± 0.012	0.237TrpCys: 0.237 ± 0.012	0.64TrpAsp: 0.64 ± 0.017	0.544TrpGlu: 0.544 ± 0.015	0.512TrpPhe: 0.512 ± 0.018	0.454TrpGly: 0.454 ± 0.017	0.199TrpHis: 0.199 ± 0.01	0.995TrpIle: 0.995 ± 0.023	0.774TrpLys: 0.774 ± 0.021	1.037TrpLeu: 1.037 ± 0.022	0.179TrpMet: 0.179 ± 0.008	0.786TrpAsn: 0.786 ± 0.022	0.292TrpPro: 0.292 ± 0.012	0.301TrpGln: 0.301 ± 0.012	0.491TrpArg: 0.491 ± 0.016	0.866TrpSer: 0.866 ± 0.02	0.46TrpThr: 0.46 ± 0.016	0.436TrpVal: 0.436 ± 0.014	0.142TrpTrp: 0.142 ± 0.009	0.443TrpTyr: 0.443 ± 0.014	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.202TyrAla: 1.202 ± 0.026	0.983TyrCys: 0.983 ± 0.023	2.1TyrAsp: 2.1 ± 0.03	2.36TyrGlu: 2.36 ± 0.037	2.055TyrPhe: 2.055 ± 0.035	1.878TyrGly: 1.878 ± 0.032	0.859TyrHis: 0.859 ± 0.019	4.631TyrIle: 4.631 ± 0.067	3.227TyrLys: 3.227 ± 0.042	4.258TyrLeu: 4.258 ± 0.055	0.892TyrMet: 0.892 ± 0.021	3.64TyrAsn: 3.64 ± 0.055	1.707TyrPro: 1.707 ± 0.031	1.531TyrGln: 1.531 ± 0.032	1.844TyrArg: 1.844 ± 0.029	4.206TyrSer: 4.206 ± 0.055	2.179TyrThr: 2.179 ± 0.034	1.536TyrVal: 1.536 ± 0.03	0.49TyrTrp: 0.49 ± 0.015	1.938TyrTyr: 1.938 ± 0.04	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.001XaaPhe: 0.001 ± 0.001	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.003XaaXaa: 0.003 ± 0.001

Statistics based on 3930 proteins (2303500 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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