Amino acid dipepetide frequency for Sulfurivirga caldicuralii

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
11.379AlaAla: 11.379 ± 0.228
1.009AlaCys: 1.009 ± 0.049
5.662AlaAsp: 5.662 ± 0.136
7.214AlaGlu: 7.214 ± 0.149
3.706AlaPhe: 3.706 ± 0.084
7.586AlaGly: 7.586 ± 0.154
2.666AlaHis: 2.666 ± 0.078
5.346AlaIle: 5.346 ± 0.102
3.83AlaLys: 3.83 ± 0.105
13.424AlaLeu: 13.424 ± 0.22
2.866AlaMet: 2.866 ± 0.077
2.575AlaAsn: 2.575 ± 0.09
4.511AlaPro: 4.511 ± 0.109
5.89AlaGln: 5.89 ± 0.137
7.017AlaArg: 7.017 ± 0.129
4.335AlaSer: 4.335 ± 0.096
4.531AlaThr: 4.531 ± 0.139
7.24AlaVal: 7.24 ± 0.129
1.861AlaTrp: 1.861 ± 0.06
2.467AlaTyr: 2.467 ± 0.075
0.0AlaXaa: 0.0 ± 0.0
Cys
0.759CysAla: 0.759 ± 0.044
0.112CysCys: 0.112 ± 0.016
0.538CysAsp: 0.538 ± 0.035
0.569CysGlu: 0.569 ± 0.035
0.238CysPhe: 0.238 ± 0.025
0.759CysGly: 0.759 ± 0.036
0.304CysHis: 0.304 ± 0.027
0.364CysIle: 0.364 ± 0.035
0.292CysLys: 0.292 ± 0.029
0.654CysLeu: 0.654 ± 0.04
0.149CysMet: 0.149 ± 0.019
0.259CysAsn: 0.259 ± 0.023
0.529CysPro: 0.529 ± 0.032
0.275CysGln: 0.275 ± 0.026
0.486CysArg: 0.486 ± 0.031
0.434CysSer: 0.434 ± 0.033
0.426CysThr: 0.426 ± 0.029
0.587CysVal: 0.587 ± 0.037
0.085CysTrp: 0.085 ± 0.015
0.223CysTyr: 0.223 ± 0.023
0.0CysXaa: 0.0 ± 0.0
Asp
6.27AspAla: 6.27 ± 0.131
0.397AspCys: 0.397 ± 0.029
3.098AspAsp: 3.098 ± 0.103
4.335AspGlu: 4.335 ± 0.103
2.291AspPhe: 2.291 ± 0.076
4.047AspGly: 4.047 ± 0.108
1.352AspHis: 1.352 ± 0.058
3.075AspIle: 3.075 ± 0.091
2.385AspLys: 2.385 ± 0.066
5.633AspLeu: 5.633 ± 0.108
1.406AspMet: 1.406 ± 0.061
1.733AspAsn: 1.733 ± 0.076
3.11AspPro: 3.11 ± 0.084
2.072AspGln: 2.072 ± 0.069
3.216AspArg: 3.216 ± 0.076
2.3AspSer: 2.3 ± 0.069
3.179AspThr: 3.179 ± 0.098
3.958AspVal: 3.958 ± 0.099
1.156AspTrp: 1.156 ± 0.049
1.899AspTyr: 1.899 ± 0.058
0.0AspXaa: 0.0 ± 0.0
Glu
8.119GluAla: 8.119 ± 0.144
0.389GluCys: 0.389 ± 0.029
3.187GluAsp: 3.187 ± 0.09
4.091GluGlu: 4.091 ± 0.126
1.644GluPhe: 1.644 ± 0.06
4.279GluGly: 4.279 ± 0.089
1.654GluHis: 1.654 ± 0.06
3.501GluIle: 3.501 ± 0.085
3.76GluLys: 3.76 ± 0.109
6.461GluLeu: 6.461 ± 0.124
1.723GluMet: 1.723 ± 0.064
2.174GluAsn: 2.174 ± 0.065
2.682GluPro: 2.682 ± 0.073
3.962GluGln: 3.962 ± 0.102
4.715GluArg: 4.715 ± 0.101
2.542GluSer: 2.542 ± 0.068
3.727GluThr: 3.727 ± 0.101
4.798GluVal: 4.798 ± 0.111
0.774GluTrp: 0.774 ± 0.036
1.39GluTyr: 1.39 ± 0.051
0.0GluXaa: 0.0 ± 0.0
Phe
3.663PheAla: 3.663 ± 0.093
0.329PheCys: 0.329 ± 0.024
2.585PheAsp: 2.585 ± 0.078
2.581PheGlu: 2.581 ± 0.075
1.534PhePhe: 1.534 ± 0.06
2.624PheGly: 2.624 ± 0.089
0.817PheHis: 0.817 ± 0.036
1.882PheIle: 1.882 ± 0.064
1.441PheLys: 1.441 ± 0.063
3.048PheLeu: 3.048 ± 0.079
0.912PheMet: 0.912 ± 0.044
1.253PheAsn: 1.253 ± 0.046
1.413PhePro: 1.413 ± 0.051
1.121PheGln: 1.121 ± 0.048
1.822PheArg: 1.822 ± 0.063
2.041PheSer: 2.041 ± 0.06
1.772PheThr: 1.772 ± 0.058
2.56PheVal: 2.56 ± 0.08
0.542PheTrp: 0.542 ± 0.031
1.152PheTyr: 1.152 ± 0.049
0.0PheXaa: 0.0 ± 0.0
Gly
6.281GlyAla: 6.281 ± 0.142
0.807GlyCys: 0.807 ± 0.043
4.064GlyAsp: 4.064 ± 0.107
4.918GlyGlu: 4.918 ± 0.103
2.949GlyPhe: 2.949 ± 0.084
5.212GlyGly: 5.212 ± 0.144
1.956GlyHis: 1.956 ± 0.06
4.024GlyIle: 4.024 ± 0.097
3.572GlyLys: 3.572 ± 0.096
7.511GlyLeu: 7.511 ± 0.145
2.244GlyMet: 2.244 ± 0.075
1.925GlyAsn: 1.925 ± 0.083
2.418GlyPro: 2.418 ± 0.077
3.046GlyGln: 3.046 ± 0.087
4.492GlyArg: 4.492 ± 0.102
3.208GlySer: 3.208 ± 0.095
3.698GlyThr: 3.698 ± 0.1
5.853GlyVal: 5.853 ± 0.116
1.324GlyTrp: 1.324 ± 0.055
2.353GlyTyr: 2.353 ± 0.072
0.0GlyXaa: 0.0 ± 0.0
His
2.755HisAla: 2.755 ± 0.077
0.316HisCys: 0.316 ± 0.025
1.365HisAsp: 1.365 ± 0.055
1.4HisGlu: 1.4 ± 0.055
1.154HisPhe: 1.154 ± 0.052
2.047HisGly: 2.047 ± 0.062
0.854HisHis: 0.854 ± 0.05
1.245HisIle: 1.245 ± 0.055
0.922HisLys: 0.922 ± 0.042
2.883HisLeu: 2.883 ± 0.076
0.592HisMet: 0.592 ± 0.034
0.724HisAsn: 0.724 ± 0.04
1.675HisPro: 1.675 ± 0.058
0.918HisGln: 0.918 ± 0.048
1.491HisArg: 1.491 ± 0.054
1.034HisSer: 1.034 ± 0.045
1.313HisThr: 1.313 ± 0.056
1.628HisVal: 1.628 ± 0.059
0.486HisTrp: 0.486 ± 0.033
0.821HisTyr: 0.821 ± 0.039
0.0HisXaa: 0.0 ± 0.0
Ile
5.621IleAla: 5.621 ± 0.112
0.383IleCys: 0.383 ± 0.031
3.601IleAsp: 3.601 ± 0.089
4.314IleGlu: 4.314 ± 0.095
1.638IlePhe: 1.638 ± 0.062
3.832IleGly: 3.832 ± 0.092
1.338IleHis: 1.338 ± 0.045
2.682IleIle: 2.682 ± 0.078
2.374IleLys: 2.374 ± 0.075
4.651IleLeu: 4.651 ± 0.098
1.059IleMet: 1.059 ± 0.046
1.867IleAsn: 1.867 ± 0.065
2.585IlePro: 2.585 ± 0.073
1.867IleGln: 1.867 ± 0.064
3.373IleArg: 3.373 ± 0.08
2.507IleSer: 2.507 ± 0.076
2.809IleThr: 2.809 ± 0.071
3.876IleVal: 3.876 ± 0.092
0.552IleTrp: 0.552 ± 0.033
1.247IleTyr: 1.247 ± 0.048
0.0IleXaa: 0.0 ± 0.0
Lys
4.982LysAla: 4.982 ± 0.109
0.211LysCys: 0.211 ± 0.021
2.184LysAsp: 2.184 ± 0.061
2.525LysGlu: 2.525 ± 0.088
0.98LysPhe: 0.98 ± 0.045
3.113LysGly: 3.113 ± 0.089
0.927LysHis: 0.927 ± 0.038
2.118LysIle: 2.118 ± 0.072
2.546LysLys: 2.546 ± 0.081
4.444LysLeu: 4.444 ± 0.107
1.082LysMet: 1.082 ± 0.047
1.272LysAsn: 1.272 ± 0.052
2.612LysPro: 2.612 ± 0.073
2.025LysGln: 2.025 ± 0.075
3.195LysArg: 3.195 ± 0.084
1.903LysSer: 1.903 ± 0.061
2.37LysThr: 2.37 ± 0.068
3.448LysVal: 3.448 ± 0.103
0.531LysTrp: 0.531 ± 0.034
0.945LysTyr: 0.945 ± 0.049
0.0LysXaa: 0.0 ± 0.0
Leu
11.877LeuAla: 11.877 ± 0.172
0.732LeuCys: 0.732 ± 0.037
6.591LeuAsp: 6.591 ± 0.109
7.05LeuGlu: 7.05 ± 0.131
3.838LeuPhe: 3.838 ± 0.1
7.59LeuGly: 7.59 ± 0.147
2.759LeuHis: 2.759 ± 0.085
5.687LeuIle: 5.687 ± 0.131
5.689LeuLys: 5.689 ± 0.112
11.949LeuLeu: 11.949 ± 0.226
2.637LeuMet: 2.637 ± 0.08
3.689LeuAsn: 3.689 ± 0.09
5.95LeuPro: 5.95 ± 0.134
5.367LeuGln: 5.367 ± 0.137
6.719LeuArg: 6.719 ± 0.125
5.652LeuSer: 5.652 ± 0.111
5.691LeuThr: 5.691 ± 0.121
7.166LeuVal: 7.166 ± 0.139
1.508LeuTrp: 1.508 ± 0.073
2.811LeuTyr: 2.811 ± 0.084
0.0LeuXaa: 0.0 ± 0.0
Met
2.962MetAla: 2.962 ± 0.079
0.145MetCys: 0.145 ± 0.018
1.381MetAsp: 1.381 ± 0.049
1.497MetGlu: 1.497 ± 0.054
0.573MetPhe: 0.573 ± 0.038
1.865MetGly: 1.865 ± 0.05
0.529MetHis: 0.529 ± 0.033
1.239MetIle: 1.239 ± 0.052
1.365MetLys: 1.365 ± 0.054
2.579MetLeu: 2.579 ± 0.065
0.637MetMet: 0.637 ± 0.029
0.873MetAsn: 0.873 ± 0.039
1.282MetPro: 1.282 ± 0.054
1.173MetGln: 1.173 ± 0.051
1.595MetArg: 1.595 ± 0.057
1.419MetSer: 1.419 ± 0.055
1.528MetThr: 1.528 ± 0.056
1.679MetVal: 1.679 ± 0.047
0.196MetTrp: 0.196 ± 0.019
0.378MetTyr: 0.378 ± 0.031
0.0MetXaa: 0.0 ± 0.0
Asn
3.179AsnAla: 3.179 ± 0.091
0.24AsnCys: 0.24 ± 0.025
1.665AsnAsp: 1.665 ± 0.077
1.746AsnGlu: 1.746 ± 0.059
0.949AsnPhe: 0.949 ± 0.044
2.432AsnGly: 2.432 ± 0.082
0.658AsnHis: 0.658 ± 0.038
1.65AsnIle: 1.65 ± 0.062
1.111AsnLys: 1.111 ± 0.046
3.139AsnLeu: 3.139 ± 0.087
0.738AsnMet: 0.738 ± 0.041
0.891AsnAsn: 0.891 ± 0.049
2.126AsnPro: 2.126 ± 0.072
1.044AsnGln: 1.044 ± 0.047
2.126AsnArg: 2.126 ± 0.065
1.169AsnSer: 1.169 ± 0.046
1.58AsnThr: 1.58 ± 0.06
1.952AsnVal: 1.952 ± 0.06
0.465AsnTrp: 0.465 ± 0.031
0.738AsnTyr: 0.738 ± 0.039
0.0AsnXaa: 0.0 ± 0.0
Pro
4.79ProAla: 4.79 ± 0.121
0.389ProCys: 0.389 ± 0.029
3.476ProAsp: 3.476 ± 0.099
4.279ProGlu: 4.279 ± 0.099
1.88ProPhe: 1.88 ± 0.055
3.561ProGly: 3.561 ± 0.083
1.22ProHis: 1.22 ± 0.053
2.418ProIle: 2.418 ± 0.061
1.867ProLys: 1.867 ± 0.075
5.445ProLeu: 5.445 ± 0.108
1.239ProMet: 1.239 ± 0.049
1.53ProAsn: 1.53 ± 0.057
2.631ProPro: 2.631 ± 0.082
2.538ProGln: 2.538 ± 0.071
2.515ProArg: 2.515 ± 0.077
2.054ProSer: 2.054 ± 0.062
2.236ProThr: 2.236 ± 0.074
4.302ProVal: 4.302 ± 0.101
0.827ProTrp: 0.827 ± 0.04
1.377ProTyr: 1.377 ± 0.048
0.0ProXaa: 0.0 ± 0.0
Gln
5.913GlnAla: 5.913 ± 0.125
0.325GlnCys: 0.325 ± 0.024
2.012GlnAsp: 2.012 ± 0.069
1.979GlnGlu: 1.979 ± 0.065
1.396GlnPhe: 1.396 ± 0.053
3.129GlnGly: 3.129 ± 0.099
1.239GlnHis: 1.239 ± 0.047
2.062GlnIle: 2.062 ± 0.062
2.043GlnLys: 2.043 ± 0.069
6.012GlnLeu: 6.012 ± 0.155
0.991GlnMet: 0.991 ± 0.043
1.044GlnAsn: 1.044 ± 0.051
2.61GlnPro: 2.61 ± 0.068
3.481GlnGln: 3.481 ± 0.118
3.448GlnArg: 3.448 ± 0.096
1.799GlnSer: 1.799 ± 0.059
2.221GlnThr: 2.221 ± 0.066
3.553GlnVal: 3.553 ± 0.101
0.809GlnTrp: 0.809 ± 0.041
0.968GlnTyr: 0.968 ± 0.043
0.0GlnXaa: 0.0 ± 0.0
Arg
5.979ArgAla: 5.979 ± 0.12
0.523ArgCys: 0.523 ± 0.033
3.241ArgAsp: 3.241 ± 0.088
4.298ArgGlu: 4.298 ± 0.103
2.809ArgPhe: 2.809 ± 0.079
3.617ArgGly: 3.617 ± 0.073
1.88ArgHis: 1.88 ± 0.064
3.975ArgIle: 3.975 ± 0.088
2.813ArgLys: 2.813 ± 0.092
7.503ArgLeu: 7.503 ± 0.15
1.69ArgMet: 1.69 ± 0.056
1.975ArgAsn: 1.975 ± 0.059
2.868ArgPro: 2.868 ± 0.079
3.152ArgGln: 3.152 ± 0.086
4.025ArgArg: 4.025 ± 0.103
2.556ArgSer: 2.556 ± 0.074
2.883ArgThr: 2.883 ± 0.076
4.388ArgVal: 4.388 ± 0.103
1.278ArgTrp: 1.278 ± 0.049
2.134ArgTyr: 2.134 ± 0.067
0.0ArgXaa: 0.0 ± 0.0
Ser
4.659SerAla: 4.659 ± 0.098
0.339SerCys: 0.339 ± 0.027
2.649SerAsp: 2.649 ± 0.081
2.984SerGlu: 2.984 ± 0.076
1.58SerPhe: 1.58 ± 0.054
3.991SerGly: 3.991 ± 0.089
1.15SerHis: 1.15 ± 0.048
2.132SerIle: 2.132 ± 0.072
1.619SerLys: 1.619 ± 0.06
4.872SerLeu: 4.872 ± 0.114
1.16SerMet: 1.16 ± 0.051
1.293SerAsn: 1.293 ± 0.06
2.258SerPro: 2.258 ± 0.068
1.824SerGln: 1.824 ± 0.061
2.74SerArg: 2.74 ± 0.082
2.318SerSer: 2.318 ± 0.079
2.151SerThr: 2.151 ± 0.065
3.286SerVal: 3.286 ± 0.09
0.635SerTrp: 0.635 ± 0.041
1.104SerTyr: 1.104 ± 0.048
0.0SerXaa: 0.0 ± 0.0
Thr
4.972ThrAla: 4.972 ± 0.091
0.416ThrCys: 0.416 ± 0.031
2.701ThrAsp: 2.701 ± 0.073
2.409ThrGlu: 2.409 ± 0.077
1.936ThrPhe: 1.936 ± 0.053
4.095ThrGly: 4.095 ± 0.105
1.392ThrHis: 1.392 ± 0.061
2.66ThrIle: 2.66 ± 0.085
1.233ThrLys: 1.233 ± 0.049
7.573ThrLeu: 7.573 ± 0.15
0.895ThrMet: 0.895 ± 0.047
1.137ThrAsn: 1.137 ± 0.051
3.648ThrPro: 3.648 ± 0.089
2.047ThrGln: 2.047 ± 0.063
2.974ThrArg: 2.974 ± 0.077
1.979ThrSer: 1.979 ± 0.068
2.475ThrThr: 2.475 ± 0.08
3.76ThrVal: 3.76 ± 0.12
0.641ThrTrp: 0.641 ± 0.042
1.224ThrTyr: 1.224 ± 0.055
0.0ThrXaa: 0.0 ± 0.0
Val
7.129ValAla: 7.129 ± 0.13
0.635ValCys: 0.635 ± 0.039
4.451ValAsp: 4.451 ± 0.093
5.087ValGlu: 5.087 ± 0.103
2.374ValPhe: 2.374 ± 0.077
5.011ValGly: 5.011 ± 0.099
1.716ValHis: 1.716 ± 0.057
4.287ValIle: 4.287 ± 0.087
3.071ValLys: 3.071 ± 0.091
7.729ValLeu: 7.729 ± 0.141
1.958ValMet: 1.958 ± 0.071
2.26ValAsn: 2.26 ± 0.072
3.679ValPro: 3.679 ± 0.086
2.935ValGln: 2.935 ± 0.088
4.571ValArg: 4.571 ± 0.096
3.727ValSer: 3.727 ± 0.1
3.528ValThr: 3.528 ± 0.12
6.167ValVal: 6.167 ± 0.129
1.038ValTrp: 1.038 ± 0.053
1.7ValTyr: 1.7 ± 0.061
0.0ValXaa: 0.0 ± 0.0
Trp
1.226TrpAla: 1.226 ± 0.053
0.134TrpCys: 0.134 ± 0.014
0.751TrpAsp: 0.751 ± 0.034
0.668TrpGlu: 0.668 ± 0.035
0.606TrpPhe: 0.606 ± 0.037
0.916TrpGly: 0.916 ± 0.049
0.507TrpHis: 0.507 ± 0.033
0.744TrpIle: 0.744 ± 0.045
0.569TrpLys: 0.569 ± 0.035
2.546TrpLeu: 2.546 ± 0.098
0.385TrpMet: 0.385 ± 0.031
0.343TrpAsn: 0.343 ± 0.023
0.728TrpPro: 0.728 ± 0.039
1.098TrpGln: 1.098 ± 0.055
1.195TrpArg: 1.195 ± 0.051
0.604TrpSer: 0.604 ± 0.036
0.622TrpThr: 0.622 ± 0.038
1.117TrpVal: 1.117 ± 0.052
0.321TrpTrp: 0.321 ± 0.026
0.366TrpTyr: 0.366 ± 0.027
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.598TyrAla: 2.598 ± 0.078
0.211TyrCys: 0.211 ± 0.023
1.708TyrAsp: 1.708 ± 0.065
1.63TyrGlu: 1.63 ± 0.057
1.017TyrPhe: 1.017 ± 0.047
2.151TyrGly: 2.151 ± 0.068
0.705TyrHis: 0.705 ± 0.034
1.086TyrIle: 1.086 ± 0.049
0.912TyrLys: 0.912 ± 0.047
2.897TyrLeu: 2.897 ± 0.079
0.531TyrMet: 0.531 ± 0.034
0.782TyrAsn: 0.782 ± 0.041
1.259TyrPro: 1.259 ± 0.05
1.2TyrGln: 1.2 ± 0.052
1.872TyrArg: 1.872 ± 0.063
1.158TyrSer: 1.158 ± 0.046
1.427TyrThr: 1.427 ± 0.056
1.735TyrVal: 1.735 ± 0.058
0.416TyrTrp: 0.416 ± 0.031
0.858TyrTyr: 0.858 ± 0.048
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1631 proteins (516464 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski