Amino acid dipepetide frequency for Pyramidobacter piscolens W5455

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	15.439AlaAla: 15.439 ± 0.219	1.515AlaCys: 1.515 ± 0.056	5.488AlaAsp: 5.488 ± 0.088	7.297AlaGlu: 7.297 ± 0.114	4.02AlaPhe: 4.02 ± 0.072	9.021AlaGly: 9.021 ± 0.109	1.551AlaHis: 1.551 ± 0.045	4.699AlaIle: 4.699 ± 0.088	4.422AlaLys: 4.422 ± 0.093	12.714AlaLeu: 12.714 ± 0.166	3.174AlaMet: 3.174 ± 0.077	2.538AlaAsn: 2.538 ± 0.068	4.399AlaPro: 4.399 ± 0.086	3.408AlaGln: 3.408 ± 0.075	7.106AlaArg: 7.106 ± 0.132	5.416AlaSer: 5.416 ± 0.097	3.794AlaThr: 3.794 ± 0.07	9.096AlaVal: 9.096 ± 0.126	1.172AlaTrp: 1.172 ± 0.037	2.419AlaTyr: 2.419 ± 0.061	0.0AlaXaa: 0.0 ± 0.0
Cys	1.771CysAla: 1.771 ± 0.054	0.306CysCys: 0.306 ± 0.017	0.814CysAsp: 0.814 ± 0.031	0.862CysGlu: 0.862 ± 0.037	0.65CysPhe: 0.65 ± 0.028	1.784CysGly: 1.784 ± 0.056	0.302CysHis: 0.302 ± 0.019	0.615CysIle: 0.615 ± 0.036	0.453CysLys: 0.453 ± 0.026	1.444CysLeu: 1.444 ± 0.048	0.36CysMet: 0.36 ± 0.024	0.348CysAsn: 0.348 ± 0.024	0.862CysPro: 0.862 ± 0.038	0.321CysGln: 0.321 ± 0.022	1.152CysArg: 1.152 ± 0.041	0.849CysSer: 0.849 ± 0.034	0.651CysThr: 0.651 ± 0.029	1.192CysVal: 1.192 ± 0.044	0.234CysTrp: 0.234 ± 0.018	0.396CysTyr: 0.396 ± 0.023	0.0CysXaa: 0.0 ± 0.0
Asp	5.426AspAla: 5.426 ± 0.097	0.761AspCys: 0.761 ± 0.029	2.567AspAsp: 2.567 ± 0.058	3.905AspGlu: 3.905 ± 0.075	2.461AspPhe: 2.461 ± 0.063	4.906AspGly: 4.906 ± 0.098	0.888AspHis: 0.888 ± 0.035	2.669AspIle: 2.669 ± 0.06	2.272AspLys: 2.272 ± 0.063	4.963AspLeu: 4.963 ± 0.08	1.472AspMet: 1.472 ± 0.041	1.224AspAsn: 1.224 ± 0.047	2.576AspPro: 2.576 ± 0.057	1.036AspGln: 1.036 ± 0.04	3.249AspArg: 3.249 ± 0.079	2.503AspSer: 2.503 ± 0.058	2.073AspThr: 2.073 ± 0.063	4.278AspVal: 4.278 ± 0.07	0.722AspTrp: 0.722 ± 0.028	1.684AspTyr: 1.684 ± 0.05	0.0AspXaa: 0.0 ± 0.0
Glu	6.439GluAla: 6.439 ± 0.114	0.699GluCys: 0.699 ± 0.032	2.813GluAsp: 2.813 ± 0.066	4.462GluGlu: 4.462 ± 0.094	2.097GluPhe: 2.097 ± 0.052	4.195GluGly: 4.195 ± 0.077	1.135GluHis: 1.135 ± 0.041	4.02GluIle: 4.02 ± 0.082	4.632GluLys: 4.632 ± 0.093	6.683GluLeu: 6.683 ± 0.113	1.982GluMet: 1.982 ± 0.056	2.648GluAsn: 2.648 ± 0.062	2.168GluPro: 2.168 ± 0.058	2.036GluGln: 2.036 ± 0.048	5.38GluArg: 5.38 ± 0.101	3.018GluSer: 3.018 ± 0.063	2.976GluThr: 2.976 ± 0.068	3.533GluVal: 3.533 ± 0.062	0.649GluTrp: 0.649 ± 0.029	1.651GluTyr: 1.651 ± 0.047	0.0GluXaa: 0.0 ± 0.0
Phe	4.372PheAla: 4.372 ± 0.084	0.876PheCys: 0.876 ± 0.036	2.395PheAsp: 2.395 ± 0.056	2.111PheGlu: 2.111 ± 0.044	2.079PhePhe: 2.079 ± 0.061	3.417PheGly: 3.417 ± 0.071	0.801PheHis: 0.801 ± 0.033	2.068PheIle: 2.068 ± 0.054	1.565PheLys: 1.565 ± 0.047	3.845PheLeu: 3.845 ± 0.075	1.215PheMet: 1.215 ± 0.05	1.133PheAsn: 1.133 ± 0.042	1.801PhePro: 1.801 ± 0.048	1.018PheGln: 1.018 ± 0.039	2.397PheArg: 2.397 ± 0.059	2.96PheSer: 2.96 ± 0.059	1.847PheThr: 1.847 ± 0.048	3.244PheVal: 3.244 ± 0.078	0.54PheTrp: 0.54 ± 0.028	1.283PheTyr: 1.283 ± 0.043	0.0PheXaa: 0.0 ± 0.0
Gly	9.208GlyAla: 9.208 ± 0.143	1.427GlyCys: 1.427 ± 0.046	4.123GlyAsp: 4.123 ± 0.084	5.192GlyGlu: 5.192 ± 0.09	3.354GlyPhe: 3.354 ± 0.064	7.191GlyGly: 7.191 ± 0.14	1.503GlyHis: 1.503 ± 0.042	4.665GlyIle: 4.665 ± 0.09	4.288GlyLys: 4.288 ± 0.088	7.948GlyLeu: 7.948 ± 0.108	2.534GlyMet: 2.534 ± 0.058	2.315GlyAsn: 2.315 ± 0.073	2.308GlyPro: 2.308 ± 0.062	2.192GlyGln: 2.192 ± 0.055	5.489GlyArg: 5.489 ± 0.099	4.677GlySer: 4.677 ± 0.092	4.467GlyThr: 4.467 ± 0.098	6.924GlyVal: 6.924 ± 0.108	1.177GlyTrp: 1.177 ± 0.041	2.525GlyTyr: 2.525 ± 0.057	0.0GlyXaa: 0.0 ± 0.0
His	1.456HisAla: 1.456 ± 0.042	0.336HisCys: 0.336 ± 0.019	0.954HisAsp: 0.954 ± 0.036	1.053HisGlu: 1.053 ± 0.038	0.791HisPhe: 0.791 ± 0.034	1.579HisGly: 1.579 ± 0.042	0.362HisHis: 0.362 ± 0.024	0.959HisIle: 0.959 ± 0.04	0.693HisLys: 0.693 ± 0.03	1.524HisLeu: 1.524 ± 0.043	0.449HisMet: 0.449 ± 0.022	0.559HisAsn: 0.559 ± 0.03	1.05HisPro: 1.05 ± 0.038	0.387HisGln: 0.387 ± 0.022	1.045HisArg: 1.045 ± 0.039	0.933HisSer: 0.933 ± 0.033	0.746HisThr: 0.746 ± 0.033	1.36HisVal: 1.36 ± 0.046	0.212HisTrp: 0.212 ± 0.018	0.574HisTyr: 0.574 ± 0.028	0.0HisXaa: 0.0 ± 0.0
Ile	5.995IleAla: 5.995 ± 0.101	0.886IleCys: 0.886 ± 0.029	3.115IleAsp: 3.115 ± 0.07	3.161IleGlu: 3.161 ± 0.064	2.268IlePhe: 2.268 ± 0.058	4.635IleGly: 4.635 ± 0.093	0.939IleHis: 0.939 ± 0.038	2.425IleIle: 2.425 ± 0.064	2.021IleLys: 2.021 ± 0.058	5.081IleLeu: 5.081 ± 0.082	1.316IleMet: 1.316 ± 0.046	1.439IleAsn: 1.439 ± 0.05	2.754IlePro: 2.754 ± 0.061	1.325IleGln: 1.325 ± 0.046	3.021IleArg: 3.021 ± 0.066	3.185IleSer: 3.185 ± 0.058	2.403IleThr: 2.403 ± 0.056	4.802IleVal: 4.802 ± 0.094	0.511IleTrp: 0.511 ± 0.027	1.46IleTyr: 1.46 ± 0.045	0.0IleXaa: 0.0 ± 0.0
Lys	4.651LysAla: 4.651 ± 0.083	0.53LysCys: 0.53 ± 0.027	2.662LysAsp: 2.662 ± 0.072	3.277LysGlu: 3.277 ± 0.072	1.561LysPhe: 1.561 ± 0.052	3.662LysGly: 3.662 ± 0.083	0.638LysHis: 0.638 ± 0.03	3.091LysIle: 3.091 ± 0.074	3.838LysLys: 3.838 ± 0.09	4.312LysLeu: 4.312 ± 0.073	1.618LysMet: 1.618 ± 0.048	2.305LysAsn: 2.305 ± 0.056	1.642LysPro: 1.642 ± 0.05	1.164LysGln: 1.164 ± 0.039	3.103LysArg: 3.103 ± 0.071	2.669LysSer: 2.669 ± 0.059	2.748LysThr: 2.748 ± 0.076	3.172LysVal: 3.172 ± 0.067	0.471LysTrp: 0.471 ± 0.025	1.486LysTyr: 1.486 ± 0.049	0.0LysXaa: 0.0 ± 0.0
Leu	10.837LeuAla: 10.837 ± 0.142	1.867LeuCys: 1.867 ± 0.049	5.587LeuAsp: 5.587 ± 0.088	5.874LeuGlu: 5.874 ± 0.104	4.097LeuPhe: 4.097 ± 0.08	8.105LeuGly: 8.105 ± 0.116	1.701LeuHis: 1.701 ± 0.052	5.23LeuIle: 5.23 ± 0.09	5.264LeuLys: 5.264 ± 0.087	10.144LeuLeu: 10.144 ± 0.182	2.69LeuMet: 2.69 ± 0.06	3.104LeuAsn: 3.104 ± 0.071	5.146LeuPro: 5.146 ± 0.095	2.62LeuGln: 2.62 ± 0.061	7.072LeuArg: 7.072 ± 0.119	6.751LeuSer: 6.751 ± 0.099	5.188LeuThr: 5.188 ± 0.093	6.269LeuVal: 6.269 ± 0.102	1.234LeuTrp: 1.234 ± 0.052	2.569LeuTyr: 2.569 ± 0.061	0.0LeuXaa: 0.0 ± 0.0
Met	2.908MetAla: 2.908 ± 0.061	0.311MetCys: 0.311 ± 0.021	1.507MetAsp: 1.507 ± 0.045	1.716MetGlu: 1.716 ± 0.05	0.89MetPhe: 0.89 ± 0.032	2.297MetGly: 2.297 ± 0.058	0.402MetHis: 0.402 ± 0.023	1.766MetIle: 1.766 ± 0.051	2.004MetLys: 2.004 ± 0.049	2.665MetLeu: 2.665 ± 0.069	0.824MetMet: 0.824 ± 0.034	1.375MetAsn: 1.375 ± 0.046	1.372MetPro: 1.372 ± 0.041	0.738MetGln: 0.738 ± 0.03	1.684MetArg: 1.684 ± 0.047	1.796MetSer: 1.796 ± 0.053	1.863MetThr: 1.863 ± 0.049	1.686MetVal: 1.686 ± 0.056	0.245MetTrp: 0.245 ± 0.015	0.659MetTyr: 0.659 ± 0.033	0.0MetXaa: 0.0 ± 0.0
Asn	3.158AsnAla: 3.158 ± 0.075	0.505AsnCys: 0.505 ± 0.031	1.546AsnAsp: 1.546 ± 0.05	1.705AsnGlu: 1.705 ± 0.047	1.359AsnPhe: 1.359 ± 0.045	2.699AsnGly: 2.699 ± 0.07	0.496AsnHis: 0.496 ± 0.028	1.64AsnIle: 1.64 ± 0.052	1.307AsnLys: 1.307 ± 0.048	2.988AsnLeu: 2.988 ± 0.069	0.912AsnMet: 0.912 ± 0.036	0.973AsnAsn: 0.973 ± 0.045	1.801AsnPro: 1.801 ± 0.047	0.696AsnGln: 0.696 ± 0.03	1.801AsnArg: 1.801 ± 0.053	1.584AsnSer: 1.584 ± 0.055	1.298AsnThr: 1.298 ± 0.058	2.748AsnVal: 2.748 ± 0.071	0.39AsnTrp: 0.39 ± 0.023	1.001AsnTyr: 1.001 ± 0.037	0.0AsnXaa: 0.0 ± 0.0
Pro	4.937ProAla: 4.937 ± 0.09	0.61ProCys: 0.61 ± 0.028	2.555ProAsp: 2.555 ± 0.063	3.76ProGlu: 3.76 ± 0.07	1.971ProPhe: 1.971 ± 0.05	3.601ProGly: 3.601 ± 0.064	0.812ProHis: 0.812 ± 0.035	1.872ProIle: 1.872 ± 0.053	1.61ProLys: 1.61 ± 0.051	4.579ProLeu: 4.579 ± 0.087	1.124ProMet: 1.124 ± 0.039	1.109ProAsn: 1.109 ± 0.04	1.657ProPro: 1.657 ± 0.051	1.54ProGln: 1.54 ± 0.042	2.792ProArg: 2.792 ± 0.067	2.372ProSer: 2.372 ± 0.053	1.736ProThr: 1.736 ± 0.049	3.771ProVal: 3.771 ± 0.083	0.6ProTrp: 0.6 ± 0.03	1.366ProTyr: 1.366 ± 0.044	0.0ProXaa: 0.0 ± 0.0
Gln	2.826GlnAla: 2.826 ± 0.08	0.34GlnCys: 0.34 ± 0.022	1.196GlnAsp: 1.196 ± 0.037	1.648GlnGlu: 1.648 ± 0.05	0.975GlnPhe: 0.975 ± 0.036	1.956GlnGly: 1.956 ± 0.055	0.408GlnHis: 0.408 ± 0.022	1.923GlnIle: 1.923 ± 0.051	1.72GlnLys: 1.72 ± 0.054	2.56GlnLeu: 2.56 ± 0.061	0.818GlnMet: 0.818 ± 0.034	1.079GlnAsn: 1.079 ± 0.037	1.125GlnPro: 1.125 ± 0.037	0.797GlnGln: 0.797 ± 0.035	1.848GlnArg: 1.848 ± 0.057	1.55GlnSer: 1.55 ± 0.05	1.368GlnThr: 1.368 ± 0.044	1.608GlnVal: 1.608 ± 0.048	0.409GlnTrp: 0.409 ± 0.025	0.844GlnTyr: 0.844 ± 0.034	0.0GlnXaa: 0.0 ± 0.0
Arg	6.456ArgAla: 6.456 ± 0.12	1.094ArgCys: 1.094 ± 0.042	3.273ArgAsp: 3.273 ± 0.074	4.743ArgGlu: 4.743 ± 0.094	2.843ArgPhe: 2.843 ± 0.068	5.11ArgGly: 5.11 ± 0.089	1.268ArgHis: 1.268 ± 0.042	3.465ArgIle: 3.465 ± 0.07	3.115ArgLys: 3.115 ± 0.069	6.988ArgLeu: 6.988 ± 0.132	1.933ArgMet: 1.933 ± 0.047	1.936ArgAsn: 1.936 ± 0.051	2.799ArgPro: 2.799 ± 0.081	2.011ArgGln: 2.011 ± 0.058	5.98ArgArg: 5.98 ± 0.11	3.626ArgSer: 3.626 ± 0.083	2.728ArgThr: 2.728 ± 0.059	4.344ArgVal: 4.344 ± 0.084	0.937ArgTrp: 0.937 ± 0.039	2.001ArgTyr: 2.001 ± 0.051	0.0ArgXaa: 0.0 ± 0.0
Ser	6.016SerAla: 6.016 ± 0.098	0.888SerCys: 0.888 ± 0.037	2.557SerAsp: 2.557 ± 0.058	3.119SerGlu: 3.119 ± 0.063	2.691SerPhe: 2.691 ± 0.061	5.565SerGly: 5.565 ± 0.095	0.999SerHis: 0.999 ± 0.04	2.835SerIle: 2.835 ± 0.062	2.059SerLys: 2.059 ± 0.058	6.269SerLeu: 6.269 ± 0.102	1.779SerMet: 1.779 ± 0.055	1.29SerAsn: 1.29 ± 0.047	2.577SerPro: 2.577 ± 0.069	1.551SerGln: 1.551 ± 0.045	3.728SerArg: 3.728 ± 0.072	3.363SerSer: 3.363 ± 0.074	2.369SerThr: 2.369 ± 0.058	4.76SerVal: 4.76 ± 0.082	0.716SerTrp: 0.716 ± 0.031	1.63SerTyr: 1.63 ± 0.046	0.0SerXaa: 0.0 ± 0.0
Thr	5.256ThrAla: 5.256 ± 0.091	0.561ThrCys: 0.561 ± 0.028	2.215ThrAsp: 2.215 ± 0.056	2.597ThrGlu: 2.597 ± 0.054	1.847ThrPhe: 1.847 ± 0.058	4.403ThrGly: 4.403 ± 0.095	0.822ThrHis: 0.822 ± 0.034	2.616ThrIle: 2.616 ± 0.067	1.715ThrLys: 1.715 ± 0.057	5.174ThrLeu: 5.174 ± 0.09	1.197ThrMet: 1.197 ± 0.036	1.192ThrAsn: 1.192 ± 0.054	2.7ThrPro: 2.7 ± 0.06	1.146ThrGln: 1.146 ± 0.038	2.298ThrArg: 2.298 ± 0.055	2.506ThrSer: 2.506 ± 0.061	2.233ThrThr: 2.233 ± 0.067	4.384ThrVal: 4.384 ± 0.078	0.508ThrTrp: 0.508 ± 0.026	1.217ThrTyr: 1.217 ± 0.039	0.0ThrXaa: 0.0 ± 0.0
Val	7.756ValAla: 7.756 ± 0.107	1.207ValCys: 1.207 ± 0.042	3.798ValAsp: 3.798 ± 0.069	4.453ValGlu: 4.453 ± 0.095	3.273ValPhe: 3.273 ± 0.066	5.702ValGly: 5.702 ± 0.102	1.238ValHis: 1.238 ± 0.041	4.279ValIle: 4.279 ± 0.091	3.744ValLys: 3.744 ± 0.076	7.332ValLeu: 7.332 ± 0.115	2.339ValMet: 2.339 ± 0.056	2.499ValAsn: 2.499 ± 0.065	3.859ValPro: 3.859 ± 0.064	1.817ValGln: 1.817 ± 0.053	4.518ValArg: 4.518 ± 0.075	4.84ValSer: 4.84 ± 0.084	4.248ValThr: 4.248 ± 0.087	6.088ValVal: 6.088 ± 0.102	0.797ValTrp: 0.797 ± 0.027	2.158ValTyr: 2.158 ± 0.059	0.0ValXaa: 0.0 ± 0.0
Trp	0.909TrpAla: 0.909 ± 0.036	0.186TrpCys: 0.186 ± 0.015	0.591TrpAsp: 0.591 ± 0.03	0.671TrpGlu: 0.671 ± 0.028	0.488TrpPhe: 0.488 ± 0.029	1.17TrpGly: 1.17 ± 0.039	0.23TrpHis: 0.23 ± 0.018	0.638TrpIle: 0.638 ± 0.029	0.708TrpLys: 0.708 ± 0.034	1.47TrpLeu: 1.47 ± 0.049	0.305TrpMet: 0.305 ± 0.02	0.556TrpAsn: 0.556 ± 0.025	0.459TrpPro: 0.459 ± 0.025	0.47TrpGln: 0.47 ± 0.025	0.893TrpArg: 0.893 ± 0.038	0.65TrpSer: 0.65 ± 0.032	0.573TrpThr: 0.573 ± 0.029	0.61TrpVal: 0.61 ± 0.033	0.173TrpTrp: 0.173 ± 0.015	0.319TrpTyr: 0.319 ± 0.024	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.87TyrAla: 2.87 ± 0.064	0.462TyrCys: 0.462 ± 0.026	1.88TyrAsp: 1.88 ± 0.056	1.61TyrGlu: 1.61 ± 0.05	1.253TyrPhe: 1.253 ± 0.043	2.512TyrGly: 2.512 ± 0.058	0.527TyrHis: 0.527 ± 0.026	1.266TyrIle: 1.266 ± 0.048	1.17TyrLys: 1.17 ± 0.044	2.666TyrLeu: 2.666 ± 0.063	0.667TyrMet: 0.667 ± 0.033	0.986TyrAsn: 0.986 ± 0.044	1.317TyrPro: 1.317 ± 0.046	0.726TyrGln: 0.726 ± 0.033	2.092TyrArg: 2.092 ± 0.059	1.514TyrSer: 1.514 ± 0.047	1.277TyrThr: 1.277 ± 0.046	2.075TyrVal: 2.075 ± 0.052	0.373TyrTrp: 0.373 ± 0.023	0.96TyrTyr: 0.96 ± 0.035	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2755 proteins (764429 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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