Amino acid dipepetide frequency for Phytoactinopolyspora halophila

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	17.158AlaAla: 17.158 ± 0.144	1.008AlaCys: 1.008 ± 0.026	8.133AlaAsp: 8.133 ± 0.078	8.491AlaGlu: 8.491 ± 0.09	3.293AlaPhe: 3.293 ± 0.053	12.161AlaGly: 12.161 ± 0.111	2.639AlaHis: 2.639 ± 0.047	4.765AlaIle: 4.765 ± 0.058	1.892AlaLys: 1.892 ± 0.043	11.937AlaLeu: 11.937 ± 0.119	2.656AlaMet: 2.656 ± 0.043	2.007AlaAsn: 2.007 ± 0.036	5.406AlaPro: 5.406 ± 0.062	3.293AlaGln: 3.293 ± 0.05	9.495AlaArg: 9.495 ± 0.105	6.666AlaSer: 6.666 ± 0.073	7.022AlaThr: 7.022 ± 0.071	10.875AlaVal: 10.875 ± 0.091	1.817AlaTrp: 1.817 ± 0.038	2.371AlaTyr: 2.371 ± 0.042	0.0AlaXaa: 0.0 ± 0.0
Cys	0.819CysAla: 0.819 ± 0.023	0.089CysCys: 0.089 ± 0.009	0.494CysAsp: 0.494 ± 0.02	0.428CysGlu: 0.428 ± 0.017	0.206CysPhe: 0.206 ± 0.011	0.884CysGly: 0.884 ± 0.026	0.224CysHis: 0.224 ± 0.014	0.196CysIle: 0.196 ± 0.012	0.082CysLys: 0.082 ± 0.008	0.608CysLeu: 0.608 ± 0.021	0.128CysMet: 0.128 ± 0.011	0.125CysAsn: 0.125 ± 0.01	0.46CysPro: 0.46 ± 0.021	0.191CysGln: 0.191 ± 0.012	0.558CysArg: 0.558 ± 0.019	0.445CysSer: 0.445 ± 0.018	0.471CysThr: 0.471 ± 0.019	0.583CysVal: 0.583 ± 0.021	0.105CysTrp: 0.105 ± 0.007	0.14CysTyr: 0.14 ± 0.01	0.0CysXaa: 0.0 ± 0.0
Asp	8.487AspAla: 8.487 ± 0.089	0.359AspCys: 0.359 ± 0.017	5.692AspAsp: 5.692 ± 0.097	5.619AspGlu: 5.619 ± 0.067	1.545AspPhe: 1.545 ± 0.031	7.215AspGly: 7.215 ± 0.092	1.598AspHis: 1.598 ± 0.036	2.51AspIle: 2.51 ± 0.039	0.767AspLys: 0.767 ± 0.024	6.213AspLeu: 6.213 ± 0.071	1.038AspMet: 1.038 ± 0.028	1.033AspAsn: 1.033 ± 0.031	4.72AspPro: 4.72 ± 0.07	1.802AspGln: 1.802 ± 0.033	4.471AspArg: 4.471 ± 0.055	2.749AspSer: 2.749 ± 0.049	3.544AspThr: 3.544 ± 0.053	6.954AspVal: 6.954 ± 0.084	0.913AspTrp: 0.913 ± 0.027	1.264AspTyr: 1.264 ± 0.03	0.0AspXaa: 0.0 ± 0.0
Glu	7.101GluAla: 7.101 ± 0.101	0.433GluCys: 0.433 ± 0.018	3.305GluAsp: 3.305 ± 0.064	3.82GluGlu: 3.82 ± 0.064	1.867GluPhe: 1.867 ± 0.037	4.146GluGly: 4.146 ± 0.065	2.002GluHis: 2.002 ± 0.036	3.12GluIle: 3.12 ± 0.045	1.126GluLys: 1.126 ± 0.034	7.693GluLeu: 7.693 ± 0.078	1.29GluMet: 1.29 ± 0.028	1.409GluAsn: 1.409 ± 0.033	4.169GluPro: 4.169 ± 0.071	2.584GluGln: 2.584 ± 0.044	6.232GluArg: 6.232 ± 0.079	3.406GluSer: 3.406 ± 0.05	3.367GluThr: 3.367 ± 0.049	4.795GluVal: 4.795 ± 0.077	0.974GluTrp: 0.974 ± 0.029	1.435GluTyr: 1.435 ± 0.04	0.0GluXaa: 0.0 ± 0.0
Phe	3.494PheAla: 3.494 ± 0.056	0.24PheCys: 0.24 ± 0.012	2.352PheAsp: 2.352 ± 0.041	1.704PheGlu: 1.704 ± 0.041	0.918PhePhe: 0.918 ± 0.03	3.094PheGly: 3.094 ± 0.052	0.637PheHis: 0.637 ± 0.022	0.947PheIle: 0.947 ± 0.025	0.363PheLys: 0.363 ± 0.017	2.502PheLeu: 2.502 ± 0.05	0.443PheMet: 0.443 ± 0.017	0.604PheAsn: 0.604 ± 0.022	1.398PhePro: 1.398 ± 0.031	0.672PheGln: 0.672 ± 0.025	1.833PheArg: 1.833 ± 0.041	1.531PheSer: 1.531 ± 0.032	1.901PheThr: 1.901 ± 0.042	2.527PheVal: 2.527 ± 0.044	0.436PheTrp: 0.436 ± 0.017	0.659PheTyr: 0.659 ± 0.022	0.0PheXaa: 0.0 ± 0.0
Gly	9.691GlyAla: 9.691 ± 0.097	0.778GlyCys: 0.778 ± 0.024	5.903GlyAsp: 5.903 ± 0.075	5.782GlyGlu: 5.782 ± 0.082	2.862GlyPhe: 2.862 ± 0.05	7.782GlyGly: 7.782 ± 0.09	2.269GlyHis: 2.269 ± 0.042	4.023GlyIle: 4.023 ± 0.053	1.732GlyLys: 1.732 ± 0.039	8.677GlyLeu: 8.677 ± 0.088	2.13GlyMet: 2.13 ± 0.038	1.831GlyAsn: 1.831 ± 0.044	4.356GlyPro: 4.356 ± 0.066	2.774GlyGln: 2.774 ± 0.043	6.693GlyArg: 6.693 ± 0.074	5.518GlySer: 5.518 ± 0.063	5.868GlyThr: 5.868 ± 0.072	7.746GlyVal: 7.746 ± 0.082	1.625GlyTrp: 1.625 ± 0.04	2.314GlyTyr: 2.314 ± 0.046	0.0GlyXaa: 0.0 ± 0.0
His	2.797HisAla: 2.797 ± 0.049	0.183HisCys: 0.183 ± 0.011	1.788HisAsp: 1.788 ± 0.042	1.548HisGlu: 1.548 ± 0.029	0.616HisPhe: 0.616 ± 0.019	2.5HisGly: 2.5 ± 0.047	0.742HisHis: 0.742 ± 0.024	0.761HisIle: 0.761 ± 0.028	0.282HisLys: 0.282 ± 0.013	2.283HisLeu: 2.283 ± 0.042	0.402HisMet: 0.402 ± 0.016	0.38HisAsn: 0.38 ± 0.016	1.677HisPro: 1.677 ± 0.034	0.699HisGln: 0.699 ± 0.022	1.962HisArg: 1.962 ± 0.041	0.993HisSer: 0.993 ± 0.023	1.215HisThr: 1.215 ± 0.027	2.22HisVal: 2.22 ± 0.042	0.329HisTrp: 0.329 ± 0.015	0.504HisTyr: 0.504 ± 0.018	0.0HisXaa: 0.0 ± 0.0
Ile	5.4IleAla: 5.4 ± 0.067	0.321IleCys: 0.321 ± 0.015	3.253IleAsp: 3.253 ± 0.055	2.781IleGlu: 2.781 ± 0.046	1.084IlePhe: 1.084 ± 0.03	4.03IleGly: 4.03 ± 0.06	0.742IleHis: 0.742 ± 0.021	1.475IleIle: 1.475 ± 0.036	0.617IleLys: 0.617 ± 0.02	3.112IleLeu: 3.112 ± 0.047	0.672IleMet: 0.672 ± 0.025	0.886IleAsn: 0.886 ± 0.023	2.12IlePro: 2.12 ± 0.045	0.877IleGln: 0.877 ± 0.024	2.811IleArg: 2.811 ± 0.054	2.208IleSer: 2.208 ± 0.04	2.564IleThr: 2.564 ± 0.041	3.817IleVal: 3.817 ± 0.053	0.515IleTrp: 0.515 ± 0.018	0.755IleTyr: 0.755 ± 0.022	0.0IleXaa: 0.0 ± 0.0
Lys	1.88LysAla: 1.88 ± 0.04	0.079LysCys: 0.079 ± 0.008	0.816LysAsp: 0.816 ± 0.027	0.888LysGlu: 0.888 ± 0.028	0.352LysPhe: 0.352 ± 0.016	1.141LysGly: 1.141 ± 0.031	0.397LysHis: 0.397 ± 0.016	0.774LysIle: 0.774 ± 0.026	0.476LysLys: 0.476 ± 0.027	1.605LysLeu: 1.605 ± 0.037	0.277LysMet: 0.277 ± 0.014	0.395LysAsn: 0.395 ± 0.017	0.955LysPro: 0.955 ± 0.028	0.561LysGln: 0.561 ± 0.022	1.278LysArg: 1.278 ± 0.032	0.916LysSer: 0.916 ± 0.029	0.95LysThr: 0.95 ± 0.028	1.358LysVal: 1.358 ± 0.033	0.17LysTrp: 0.17 ± 0.012	0.337LysTyr: 0.337 ± 0.016	0.0LysXaa: 0.0 ± 0.0
Leu	13.797LeuAla: 13.797 ± 0.12	0.68LeuCys: 0.68 ± 0.021	7.433LeuAsp: 7.433 ± 0.075	5.329LeuGlu: 5.329 ± 0.066	2.569LeuPhe: 2.569 ± 0.05	8.874LeuGly: 8.874 ± 0.098	2.139LeuHis: 2.139 ± 0.041	3.719LeuIle: 3.719 ± 0.063	1.349LeuLys: 1.349 ± 0.037	9.444LeuLeu: 9.444 ± 0.112	1.639LeuMet: 1.639 ± 0.039	1.746LeuAsn: 1.746 ± 0.034	5.453LeuPro: 5.453 ± 0.067	2.311LeuGln: 2.311 ± 0.041	7.734LeuArg: 7.734 ± 0.082	5.235LeuSer: 5.235 ± 0.069	5.799LeuThr: 5.799 ± 0.066	8.883LeuVal: 8.883 ± 0.093	1.191LeuTrp: 1.191 ± 0.032	1.755LeuTyr: 1.755 ± 0.035	0.0LeuXaa: 0.0 ± 0.0
Met	2.402MetAla: 2.402 ± 0.044	0.147MetCys: 0.147 ± 0.011	0.972MetAsp: 0.972 ± 0.025	0.875MetGlu: 0.875 ± 0.024	0.574MetPhe: 0.574 ± 0.021	1.348MetGly: 1.348 ± 0.036	0.401MetHis: 0.401 ± 0.017	0.93MetIle: 0.93 ± 0.024	0.366MetLys: 0.366 ± 0.015	2.073MetLeu: 2.073 ± 0.038	0.378MetMet: 0.378 ± 0.017	0.477MetAsn: 0.477 ± 0.02	1.271MetPro: 1.271 ± 0.03	0.503MetGln: 0.503 ± 0.018	1.663MetArg: 1.663 ± 0.034	1.514MetSer: 1.514 ± 0.03	1.6MetThr: 1.6 ± 0.037	1.591MetVal: 1.591 ± 0.036	0.246MetTrp: 0.246 ± 0.013	0.369MetTyr: 0.369 ± 0.015	0.0MetXaa: 0.0 ± 0.0
Asn	2.298AsnAla: 2.298 ± 0.04	0.138AsnCys: 0.138 ± 0.01	1.232AsnAsp: 1.232 ± 0.03	1.165AsnGlu: 1.165 ± 0.03	0.498AsnPhe: 0.498 ± 0.019	1.837AsnGly: 1.837 ± 0.041	0.418AsnHis: 0.418 ± 0.018	0.762AsnIle: 0.762 ± 0.025	0.288AsnLys: 0.288 ± 0.016	1.767AsnLeu: 1.767 ± 0.038	0.353AsnMet: 0.353 ± 0.017	0.445AsnAsn: 0.445 ± 0.018	1.469AsnPro: 1.469 ± 0.033	0.573AsnGln: 0.573 ± 0.019	1.366AsnArg: 1.366 ± 0.033	0.947AsnSer: 0.947 ± 0.027	1.132AsnThr: 1.132 ± 0.027	1.764AsnVal: 1.764 ± 0.03	0.301AsnTrp: 0.301 ± 0.015	0.454AsnTyr: 0.454 ± 0.019	0.0AsnXaa: 0.0 ± 0.0
Pro	6.658ProAla: 6.658 ± 0.075	0.304ProCys: 0.304 ± 0.013	4.977ProAsp: 4.977 ± 0.06	4.636ProGlu: 4.636 ± 0.065	1.574ProPhe: 1.574 ± 0.038	5.864ProGly: 5.864 ± 0.069	1.363ProHis: 1.363 ± 0.03	1.786ProIle: 1.786 ± 0.035	0.777ProLys: 0.777 ± 0.028	4.528ProLeu: 4.528 ± 0.063	1.066ProMet: 1.066 ± 0.03	1.004ProAsn: 1.004 ± 0.029	3.165ProPro: 3.165 ± 0.059	1.549ProGln: 1.549 ± 0.035	3.447ProArg: 3.447 ± 0.052	3.326ProSer: 3.326 ± 0.049	3.078ProThr: 3.078 ± 0.048	5.007ProVal: 5.007 ± 0.06	0.898ProTrp: 0.898 ± 0.027	1.203ProTyr: 1.203 ± 0.024	0.0ProXaa: 0.0 ± 0.0
Gln	3.499GlnAla: 3.499 ± 0.049	0.175GlnCys: 0.175 ± 0.011	1.387GlnAsp: 1.387 ± 0.031	1.608GlnGlu: 1.608 ± 0.034	0.748GlnPhe: 0.748 ± 0.021	1.883GlnGly: 1.883 ± 0.037	0.835GlnHis: 0.835 ± 0.026	1.329GlnIle: 1.329 ± 0.034	0.465GlnLys: 0.465 ± 0.017	3.31GlnLeu: 3.31 ± 0.053	0.639GlnMet: 0.639 ± 0.023	0.538GlnAsn: 0.538 ± 0.021	1.809GlnPro: 1.809 ± 0.038	1.18GlnGln: 1.18 ± 0.035	2.709GlnArg: 2.709 ± 0.048	1.297GlnSer: 1.297 ± 0.03	1.374GlnThr: 1.374 ± 0.034	2.522GlnVal: 2.522 ± 0.039	0.466GlnTrp: 0.466 ± 0.02	0.598GlnTyr: 0.598 ± 0.02	0.0GlnXaa: 0.0 ± 0.0
Arg	9.005ArgAla: 9.005 ± 0.103	0.583ArgCys: 0.583 ± 0.022	4.75ArgAsp: 4.75 ± 0.06	4.94ArgGlu: 4.94 ± 0.063	2.292ArgPhe: 2.292 ± 0.044	5.451ArgGly: 5.451 ± 0.07	2.157ArgHis: 2.157 ± 0.039	3.427ArgIle: 3.427 ± 0.047	1.344ArgLys: 1.344 ± 0.034	7.824ArgLeu: 7.824 ± 0.087	1.778ArgMet: 1.778 ± 0.035	1.448ArgAsn: 1.448 ± 0.035	4.097ArgPro: 4.097 ± 0.055	2.596ArgGln: 2.596 ± 0.042	7.499ArgArg: 7.499 ± 0.091	4.502ArgSer: 4.502 ± 0.053	4.438ArgThr: 4.438 ± 0.054	5.894ArgVal: 5.894 ± 0.063	1.467ArgTrp: 1.467 ± 0.028	1.84ArgTyr: 1.84 ± 0.039	0.0ArgXaa: 0.0 ± 0.0
Ser	6.551SerAla: 6.551 ± 0.072	0.398SerCys: 0.398 ± 0.017	3.486SerAsp: 3.486 ± 0.053	3.249SerGlu: 3.249 ± 0.052	1.672SerPhe: 1.672 ± 0.038	6.215SerGly: 6.215 ± 0.074	1.156SerHis: 1.156 ± 0.028	2.081SerIle: 2.081 ± 0.039	0.877SerLys: 0.877 ± 0.028	4.839SerLeu: 4.839 ± 0.061	1.294SerMet: 1.294 ± 0.033	1.043SerAsn: 1.043 ± 0.028	3.103SerPro: 3.103 ± 0.05	1.421SerGln: 1.421 ± 0.031	3.968SerArg: 3.968 ± 0.049	3.494SerSer: 3.494 ± 0.061	3.654SerThr: 3.654 ± 0.055	4.699SerVal: 4.699 ± 0.067	1.072SerTrp: 1.072 ± 0.027	1.278SerTyr: 1.278 ± 0.034	0.0SerXaa: 0.0 ± 0.0
Thr	7.024ThrAla: 7.024 ± 0.07	0.395ThrCys: 0.395 ± 0.016	3.592ThrAsp: 3.592 ± 0.052	3.363ThrGlu: 3.363 ± 0.053	1.926ThrPhe: 1.926 ± 0.04	5.986ThrGly: 5.986 ± 0.077	1.23ThrHis: 1.23 ± 0.029	2.523ThrIle: 2.523 ± 0.051	0.954ThrLys: 0.954 ± 0.03	5.76ThrLeu: 5.76 ± 0.061	1.281ThrMet: 1.281 ± 0.027	1.144ThrAsn: 1.144 ± 0.028	3.626ThrPro: 3.626 ± 0.051	1.355ThrGln: 1.355 ± 0.031	3.9ThrArg: 3.9 ± 0.05	3.733ThrSer: 3.733 ± 0.051	3.827ThrThr: 3.827 ± 0.059	5.867ThrVal: 5.867 ± 0.073	0.961ThrTrp: 0.961 ± 0.027	1.388ThrTyr: 1.388 ± 0.037	0.0ThrXaa: 0.0 ± 0.0
Val	11.129ValAla: 11.129 ± 0.106	0.616ValCys: 0.616 ± 0.023	6.584ValAsp: 6.584 ± 0.069	5.844ValGlu: 5.844 ± 0.077	2.464ValPhe: 2.464 ± 0.047	6.932ValGly: 6.932 ± 0.074	2.049ValHis: 2.049 ± 0.041	3.604ValIle: 3.604 ± 0.055	1.296ValLys: 1.296 ± 0.032	8.958ValLeu: 8.958 ± 0.099	1.554ValMet: 1.554 ± 0.038	1.825ValAsn: 1.825 ± 0.037	5.009ValPro: 5.009 ± 0.066	2.178ValGln: 2.178 ± 0.038	6.585ValArg: 6.585 ± 0.075	4.977ValSer: 4.977 ± 0.061	5.87ValThr: 5.87 ± 0.075	8.935ValVal: 8.935 ± 0.092	1.048ValTrp: 1.048 ± 0.027	1.622ValTyr: 1.622 ± 0.034	0.0ValXaa: 0.0 ± 0.0
Trp	1.454TrpAla: 1.454 ± 0.039	0.143TrpCys: 0.143 ± 0.01	0.832TrpAsp: 0.832 ± 0.025	0.79TrpGlu: 0.79 ± 0.027	0.566TrpPhe: 0.566 ± 0.018	0.957TrpGly: 0.957 ± 0.028	0.428TrpHis: 0.428 ± 0.015	0.644TrpIle: 0.644 ± 0.022	0.277TrpLys: 0.277 ± 0.013	1.787TrpLeu: 1.787 ± 0.039	0.367TrpMet: 0.367 ± 0.016	0.474TrpAsn: 0.474 ± 0.018	0.804TrpPro: 0.804 ± 0.023	0.593TrpGln: 0.593 ± 0.024	1.284TrpArg: 1.284 ± 0.033	1.058TrpSer: 1.058 ± 0.031	0.992TrpThr: 0.992 ± 0.025	1.082TrpVal: 1.082 ± 0.026	0.379TrpTrp: 0.379 ± 0.016	0.364TrpTyr: 0.364 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.442TyrAla: 2.442 ± 0.042	0.168TyrCys: 0.168 ± 0.012	1.514TyrAsp: 1.514 ± 0.042	1.413TyrGlu: 1.413 ± 0.029	0.629TyrPhe: 0.629 ± 0.021	2.052TyrGly: 2.052 ± 0.04	0.454TyrHis: 0.454 ± 0.018	0.665TyrIle: 0.665 ± 0.024	0.273TyrLys: 0.273 ± 0.014	2.164TyrLeu: 2.164 ± 0.04	0.312TyrMet: 0.312 ± 0.016	0.392TyrAsn: 0.392 ± 0.018	1.142TyrPro: 1.142 ± 0.025	0.657TyrGln: 0.657 ± 0.021	1.846TyrArg: 1.846 ± 0.037	1.035TyrSer: 1.035 ± 0.026	1.17TyrThr: 1.17 ± 0.03	1.959TyrVal: 1.959 ± 0.043	0.359TyrTrp: 0.359 ± 0.016	0.498TyrTyr: 0.498 ± 0.02	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4405 proteins (1472675 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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