Amino acid dipepetide frequency for Candidatus Erwinia haradaeae

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.108AlaAla: 5.108 ± 0.189
1.043AlaCys: 1.043 ± 0.071
2.847AlaAsp: 2.847 ± 0.131
3.385AlaGlu: 3.385 ± 0.161
2.526AlaPhe: 2.526 ± 0.115
4.4AlaGly: 4.4 ± 0.158
1.784AlaHis: 1.784 ± 0.1
6.623AlaIle: 6.623 ± 0.199
3.597AlaLys: 3.597 ± 0.128
8.648AlaLeu: 8.648 ± 0.229
2.115AlaMet: 2.115 ± 0.11
2.903AlaAsn: 2.903 ± 0.128
1.846AlaPro: 1.846 ± 0.092
2.955AlaGln: 2.955 ± 0.118
4.013AlaArg: 4.013 ± 0.152
4.315AlaSer: 4.315 ± 0.148
3.531AlaThr: 3.531 ± 0.117
4.456AlaVal: 4.456 ± 0.161
0.831AlaTrp: 0.831 ± 0.066
2.002AlaTyr: 2.002 ± 0.095
0.0AlaXaa: 0.0 ± 0.0
Cys
1.039CysAla: 1.039 ± 0.063
0.203CysCys: 0.203 ± 0.038
0.609CysAsp: 0.609 ± 0.052
0.571CysGlu: 0.571 ± 0.054
0.595CysPhe: 0.595 ± 0.049
1.194CysGly: 1.194 ± 0.091
0.43CysHis: 0.43 ± 0.047
1.223CysIle: 1.223 ± 0.084
0.6CysLys: 0.6 ± 0.054
1.52CysLeu: 1.52 ± 0.1
0.401CysMet: 0.401 ± 0.041
0.685CysAsn: 0.685 ± 0.052
0.562CysPro: 0.562 ± 0.052
0.581CysGln: 0.581 ± 0.051
0.718CysArg: 0.718 ± 0.059
1.142CysSer: 1.142 ± 0.076
0.708CysThr: 0.708 ± 0.053
0.779CysVal: 0.779 ± 0.065
0.203CysTrp: 0.203 ± 0.029
0.59CysTyr: 0.59 ± 0.058
0.0CysXaa: 0.0 ± 0.0
Asp
3.125AspAla: 3.125 ± 0.132
0.755AspCys: 0.755 ± 0.054
1.832AspAsp: 1.832 ± 0.11
2.101AspGlu: 2.101 ± 0.106
1.997AspPhe: 1.997 ± 0.105
2.899AspGly: 2.899 ± 0.127
1.308AspHis: 1.308 ± 0.083
4.966AspIle: 4.966 ± 0.15
2.426AspLys: 2.426 ± 0.131
4.995AspLeu: 4.995 ± 0.165
1.289AspMet: 1.289 ± 0.086
2.36AspAsn: 2.36 ± 0.119
1.78AspPro: 1.78 ± 0.086
1.992AspGln: 1.992 ± 0.09
2.53AspArg: 2.53 ± 0.111
2.757AspSer: 2.757 ± 0.126
2.582AspThr: 2.582 ± 0.108
3.153AspVal: 3.153 ± 0.126
0.628AspTrp: 0.628 ± 0.06
1.666AspTyr: 1.666 ± 0.093
0.0AspXaa: 0.0 ± 0.0
Glu
3.673GluAla: 3.673 ± 0.162
0.628GluCys: 0.628 ± 0.053
2.186GluAsp: 2.186 ± 0.093
2.776GluGlu: 2.776 ± 0.128
1.78GluPhe: 1.78 ± 0.087
2.71GluGly: 2.71 ± 0.123
1.445GluHis: 1.445 ± 0.082
4.551GluIle: 4.551 ± 0.146
3.578GluLys: 3.578 ± 0.137
4.891GluLeu: 4.891 ± 0.156
1.454GluMet: 1.454 ± 0.088
2.266GluAsn: 2.266 ± 0.104
1.478GluPro: 1.478 ± 0.08
2.124GluGln: 2.124 ± 0.112
3.29GluArg: 3.29 ± 0.163
2.913GluSer: 2.913 ± 0.112
2.455GluThr: 2.455 ± 0.118
3.479GluVal: 3.479 ± 0.147
0.519GluTrp: 0.519 ± 0.055
1.534GluTyr: 1.534 ± 0.09
0.0GluXaa: 0.0 ± 0.0
Phe
1.983PheAla: 1.983 ± 0.105
0.675PheCys: 0.675 ± 0.061
1.78PheAsp: 1.78 ± 0.09
1.534PheGlu: 1.534 ± 0.083
1.879PhePhe: 1.879 ± 0.107
2.733PheGly: 2.733 ± 0.111
0.996PheHis: 0.996 ± 0.069
3.465PheIle: 3.465 ± 0.131
1.69PheLys: 1.69 ± 0.085
3.871PheLeu: 3.871 ± 0.152
0.949PheMet: 0.949 ± 0.07
1.997PheAsn: 1.997 ± 0.092
1.459PhePro: 1.459 ± 0.089
1.36PheGln: 1.36 ± 0.085
1.714PheArg: 1.714 ± 0.078
4.017PheSer: 4.017 ± 0.156
1.997PheThr: 1.997 ± 0.114
1.865PheVal: 1.865 ± 0.103
0.472PheTrp: 0.472 ± 0.053
1.435PheTyr: 1.435 ± 0.095
0.0PheXaa: 0.0 ± 0.0
Gly
4.225GlyAla: 4.225 ± 0.165
1.161GlyCys: 1.161 ± 0.065
3.248GlyAsp: 3.248 ± 0.135
3.356GlyGlu: 3.356 ± 0.132
2.757GlyPhe: 2.757 ± 0.109
4.537GlyGly: 4.537 ± 0.179
2.058GlyHis: 2.058 ± 0.1
5.972GlyIle: 5.972 ± 0.185
3.833GlyLys: 3.833 ± 0.14
6.472GlyLeu: 6.472 ± 0.208
1.983GlyMet: 1.983 ± 0.084
2.441GlyAsn: 2.441 ± 0.103
1.614GlyPro: 1.614 ± 0.089
2.426GlyGln: 2.426 ± 0.101
3.503GlyArg: 3.503 ± 0.136
4.471GlySer: 4.471 ± 0.152
3.215GlyThr: 3.215 ± 0.118
5.098GlyVal: 5.098 ± 0.161
0.807GlyTrp: 0.807 ± 0.074
2.341GlyTyr: 2.341 ± 0.102
0.0GlyXaa: 0.0 ± 0.0
His
2.143HisAla: 2.143 ± 0.097
0.496HisCys: 0.496 ± 0.044
1.345HisAsp: 1.345 ± 0.075
1.218HisGlu: 1.218 ± 0.074
1.114HisPhe: 1.114 ± 0.075
2.304HisGly: 2.304 ± 0.093
1.024HisHis: 1.024 ± 0.085
2.393HisIle: 2.393 ± 0.105
1.412HisLys: 1.412 ± 0.08
2.587HisLeu: 2.587 ± 0.127
0.751HisMet: 0.751 ± 0.067
1.454HisAsn: 1.454 ± 0.083
1.506HisPro: 1.506 ± 0.098
1.459HisGln: 1.459 ± 0.084
1.572HisArg: 1.572 ± 0.107
1.737HisSer: 1.737 ± 0.088
1.586HisThr: 1.586 ± 0.081
1.652HisVal: 1.652 ± 0.09
0.368HisTrp: 0.368 ± 0.041
1.048HisTyr: 1.048 ± 0.06
0.0HisXaa: 0.0 ± 0.0
Ile
7.062IleAla: 7.062 ± 0.199
1.265IleCys: 1.265 ± 0.076
4.877IleAsp: 4.877 ± 0.145
4.683IleGlu: 4.683 ± 0.157
3.13IlePhe: 3.13 ± 0.138
6.231IleGly: 6.231 ± 0.178
2.247IleHis: 2.247 ± 0.101
7.308IleIle: 7.308 ± 0.208
4.603IleLys: 4.603 ± 0.155
8.762IleLeu: 8.762 ± 0.209
2.039IleMet: 2.039 ± 0.098
4.617IleAsn: 4.617 ± 0.159
3.668IlePro: 3.668 ± 0.139
3.484IleGln: 3.484 ± 0.14
4.253IleArg: 4.253 ± 0.122
6.68IleSer: 6.68 ± 0.192
5.401IleThr: 5.401 ± 0.147
4.749IleVal: 4.749 ± 0.15
0.892IleTrp: 0.892 ± 0.078
2.516IleTyr: 2.516 ± 0.097
0.0IleXaa: 0.0 ± 0.0
Lys
3.418LysAla: 3.418 ± 0.14
0.458LysCys: 0.458 ± 0.048
2.601LysAsp: 2.601 ± 0.13
2.865LysGlu: 2.865 ± 0.128
1.685LysPhe: 1.685 ± 0.094
2.969LysGly: 2.969 ± 0.126
1.534LysHis: 1.534 ± 0.085
5.552LysIle: 5.552 ± 0.157
4.386LysLys: 4.386 ± 0.174
5.273LysLeu: 5.273 ± 0.171
1.463LysMet: 1.463 ± 0.08
3.711LysAsn: 3.711 ± 0.132
1.879LysPro: 1.879 ± 0.077
2.266LysGln: 2.266 ± 0.103
3.21LysArg: 3.21 ± 0.123
3.484LysSer: 3.484 ± 0.135
3.399LysThr: 3.399 ± 0.132
3.177LysVal: 3.177 ± 0.119
0.533LysTrp: 0.533 ± 0.047
1.69LysTyr: 1.69 ± 0.085
0.0LysXaa: 0.0 ± 0.0
Leu
7.577LeuAla: 7.577 ± 0.217
1.567LeuCys: 1.567 ± 0.096
5.169LeuAsp: 5.169 ± 0.149
5.622LeuGlu: 5.622 ± 0.169
3.805LeuPhe: 3.805 ± 0.168
6.727LeuGly: 6.727 ± 0.187
3.187LeuHis: 3.187 ± 0.134
8.275LeuIle: 8.275 ± 0.234
5.948LeuLys: 5.948 ± 0.193
11.108LeuLeu: 11.108 ± 0.283
2.757LeuMet: 2.757 ± 0.133
4.9LeuAsn: 4.9 ± 0.135
4.4LeuPro: 4.4 ± 0.153
4.272LeuGln: 4.272 ± 0.133
5.712LeuArg: 5.712 ± 0.161
8.101LeuSer: 8.101 ± 0.248
5.821LeuThr: 5.821 ± 0.173
6.552LeuVal: 6.552 ± 0.186
1.128LeuTrp: 1.128 ± 0.083
3.333LeuTyr: 3.333 ± 0.137
0.0LeuXaa: 0.0 ± 0.0
Met
1.945MetAla: 1.945 ± 0.096
0.312MetCys: 0.312 ± 0.038
1.109MetAsp: 1.109 ± 0.074
1.138MetGlu: 1.138 ± 0.077
0.845MetPhe: 0.845 ± 0.058
1.652MetGly: 1.652 ± 0.09
0.949MetHis: 0.949 ± 0.07
2.275MetIle: 2.275 ± 0.11
1.553MetLys: 1.553 ± 0.077
3.083MetLeu: 3.083 ± 0.139
0.902MetMet: 0.902 ± 0.067
1.27MetAsn: 1.27 ± 0.077
1.317MetPro: 1.317 ± 0.07
1.26MetGln: 1.26 ± 0.071
1.704MetArg: 1.704 ± 0.091
1.95MetSer: 1.95 ± 0.096
1.482MetThr: 1.482 ± 0.074
1.506MetVal: 1.506 ± 0.086
0.179MetTrp: 0.179 ± 0.027
0.6MetTyr: 0.6 ± 0.055
0.0MetXaa: 0.0 ± 0.0
Asn
3.29AsnAla: 3.29 ± 0.118
0.548AsnCys: 0.548 ± 0.052
2.054AsnAsp: 2.054 ± 0.115
1.865AsnGlu: 1.865 ± 0.112
1.784AsnPhe: 1.784 ± 0.101
2.766AsnGly: 2.766 ± 0.128
1.44AsnHis: 1.44 ± 0.088
5.032AsnIle: 5.032 ± 0.153
2.644AsnLys: 2.644 ± 0.114
4.976AsnLeu: 4.976 ± 0.154
1.029AsnMet: 1.029 ± 0.059
2.611AsnAsn: 2.611 ± 0.138
2.318AsnPro: 2.318 ± 0.125
2.403AsnGln: 2.403 ± 0.102
2.412AsnArg: 2.412 ± 0.105
2.828AsnSer: 2.828 ± 0.118
2.908AsnThr: 2.908 ± 0.109
2.365AsnVal: 2.365 ± 0.104
0.642AsnTrp: 0.642 ± 0.062
1.666AsnTyr: 1.666 ± 0.09
0.0AsnXaa: 0.0 ± 0.0
Pro
2.072ProAla: 2.072 ± 0.098
0.463ProCys: 0.463 ± 0.047
1.987ProAsp: 1.987 ± 0.083
2.375ProGlu: 2.375 ± 0.104
1.468ProPhe: 1.468 ± 0.076
2.644ProGly: 2.644 ± 0.117
1.048ProHis: 1.048 ± 0.07
3.248ProIle: 3.248 ± 0.135
1.921ProLys: 1.921 ± 0.092
4.05ProLeu: 4.05 ± 0.123
1.039ProMet: 1.039 ± 0.064
1.666ProAsn: 1.666 ± 0.089
1.157ProPro: 1.157 ± 0.072
1.44ProGln: 1.44 ± 0.075
1.511ProArg: 1.511 ± 0.086
2.327ProSer: 2.327 ± 0.1
1.874ProThr: 1.874 ± 0.096
2.908ProVal: 2.908 ± 0.131
0.496ProTrp: 0.496 ± 0.042
1.468ProTyr: 1.468 ± 0.081
0.0ProXaa: 0.0 ± 0.0
Gln
3.262GlnAla: 3.262 ± 0.114
0.689GlnCys: 0.689 ± 0.051
1.902GlnAsp: 1.902 ± 0.091
2.37GlnGlu: 2.37 ± 0.11
1.412GlnPhe: 1.412 ± 0.078
2.464GlnGly: 2.464 ± 0.092
1.161GlnHis: 1.161 ± 0.083
3.281GlnIle: 3.281 ± 0.119
3.002GlnLys: 3.002 ± 0.111
4.64GlnLeu: 4.64 ± 0.155
1.039GlnMet: 1.039 ± 0.072
1.931GlnAsn: 1.931 ± 0.11
1.473GlnPro: 1.473 ± 0.087
1.643GlnGln: 1.643 ± 0.104
2.568GlnArg: 2.568 ± 0.111
2.318GlnSer: 2.318 ± 0.099
1.865GlnThr: 1.865 ± 0.095
2.828GlnVal: 2.828 ± 0.117
0.519GlnTrp: 0.519 ± 0.049
1.832GlnTyr: 1.832 ± 0.092
0.0GlnXaa: 0.0 ± 0.0
Arg
3.489ArgAla: 3.489 ± 0.151
0.694ArgCys: 0.694 ± 0.058
2.578ArgAsp: 2.578 ± 0.106
2.988ArgGlu: 2.988 ± 0.129
2.483ArgPhe: 2.483 ± 0.115
3.201ArgGly: 3.201 ± 0.146
1.61ArgHis: 1.61 ± 0.085
4.858ArgIle: 4.858 ± 0.152
2.969ArgLys: 2.969 ± 0.125
5.434ArgLeu: 5.434 ± 0.188
1.511ArgMet: 1.511 ± 0.09
2.441ArgAsn: 2.441 ± 0.11
1.917ArgPro: 1.917 ± 0.095
2.474ArgGln: 2.474 ± 0.109
3.083ArgArg: 3.083 ± 0.116
3.371ArgSer: 3.371 ± 0.134
2.582ArgThr: 2.582 ± 0.121
3.512ArgVal: 3.512 ± 0.142
0.666ArgTrp: 0.666 ± 0.054
2.162ArgTyr: 2.162 ± 0.092
0.0ArgXaa: 0.0 ± 0.0
Ser
4.801SerAla: 4.801 ± 0.136
0.935SerCys: 0.935 ± 0.063
3.38SerAsp: 3.38 ± 0.129
3.413SerGlu: 3.413 ± 0.12
2.54SerPhe: 2.54 ± 0.114
5.377SerGly: 5.377 ± 0.158
1.898SerHis: 1.898 ± 0.082
5.679SerIle: 5.679 ± 0.202
3.522SerLys: 3.522 ± 0.121
7.067SerLeu: 7.067 ± 0.203
1.827SerMet: 1.827 ± 0.095
3.031SerAsn: 3.031 ± 0.128
2.351SerPro: 2.351 ± 0.099
2.776SerGln: 2.776 ± 0.115
3.559SerArg: 3.559 ± 0.145
4.82SerSer: 4.82 ± 0.171
3.413SerThr: 3.413 ± 0.125
4.489SerVal: 4.489 ± 0.129
0.845SerTrp: 0.845 ± 0.071
2.384SerTyr: 2.384 ± 0.099
0.0SerXaa: 0.0 ± 0.0
Thr
3.64ThrAla: 3.64 ± 0.118
0.741ThrCys: 0.741 ± 0.062
2.464ThrAsp: 2.464 ± 0.109
2.733ThrGlu: 2.733 ± 0.115
1.893ThrPhe: 1.893 ± 0.094
4.116ThrGly: 4.116 ± 0.137
1.614ThrHis: 1.614 ± 0.083
4.31ThrIle: 4.31 ± 0.154
2.54ThrLys: 2.54 ± 0.111
6.557ThrLeu: 6.557 ± 0.167
1.369ThrMet: 1.369 ± 0.075
2.299ThrAsn: 2.299 ± 0.093
2.384ThrPro: 2.384 ± 0.103
2.464ThrGln: 2.464 ± 0.103
2.804ThrArg: 2.804 ± 0.114
3.286ThrSer: 3.286 ± 0.117
2.941ThrThr: 2.941 ± 0.108
3.531ThrVal: 3.531 ± 0.134
0.689ThrTrp: 0.689 ± 0.053
1.506ThrTyr: 1.506 ± 0.081
0.0ThrXaa: 0.0 ± 0.0
Val
4.083ValAla: 4.083 ± 0.148
0.897ValCys: 0.897 ± 0.068
3.135ValAsp: 3.135 ± 0.127
3.026ValGlu: 3.026 ± 0.108
2.398ValPhe: 2.398 ± 0.111
3.81ValGly: 3.81 ± 0.143
1.737ValHis: 1.737 ± 0.091
5.712ValIle: 5.712 ± 0.188
3.144ValLys: 3.144 ± 0.114
6.906ValLeu: 6.906 ± 0.201
1.987ValMet: 1.987 ± 0.091
2.927ValAsn: 2.927 ± 0.12
2.214ValPro: 2.214 ± 0.099
2.412ValGln: 2.412 ± 0.106
3.163ValArg: 3.163 ± 0.121
4.716ValSer: 4.716 ± 0.187
3.913ValThr: 3.913 ± 0.145
4.277ValVal: 4.277 ± 0.155
0.515ValTrp: 0.515 ± 0.053
1.704ValTyr: 1.704 ± 0.094
0.0ValXaa: 0.0 ± 0.0
Trp
0.585TrpAla: 0.585 ± 0.046
0.217TrpCys: 0.217 ± 0.036
0.397TrpAsp: 0.397 ± 0.047
0.482TrpGlu: 0.482 ± 0.049
0.562TrpPhe: 0.562 ± 0.062
0.637TrpGly: 0.637 ± 0.055
0.439TrpHis: 0.439 ± 0.046
0.977TrpIle: 0.977 ± 0.071
0.699TrpLys: 0.699 ± 0.059
1.614TrpLeu: 1.614 ± 0.096
0.354TrpMet: 0.354 ± 0.044
0.486TrpAsn: 0.486 ± 0.048
0.43TrpPro: 0.43 ± 0.045
0.59TrpGln: 0.59 ± 0.053
0.793TrpArg: 0.793 ± 0.067
0.656TrpSer: 0.656 ± 0.06
0.425TrpThr: 0.425 ± 0.048
0.699TrpVal: 0.699 ± 0.06
0.156TrpTrp: 0.156 ± 0.027
0.397TrpTyr: 0.397 ± 0.049
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.408TyrAla: 2.408 ± 0.117
0.604TyrCys: 0.604 ± 0.053
1.643TyrAsp: 1.643 ± 0.089
1.227TyrGlu: 1.227 ± 0.076
1.218TyrPhe: 1.218 ± 0.08
2.148TyrGly: 2.148 ± 0.113
1.26TyrHis: 1.26 ± 0.076
2.766TyrIle: 2.766 ± 0.106
1.487TyrLys: 1.487 ± 0.086
3.508TyrLeu: 3.508 ± 0.14
0.769TyrMet: 0.769 ± 0.068
1.586TyrAsn: 1.586 ± 0.089
1.412TyrPro: 1.412 ± 0.089
1.817TyrGln: 1.817 ± 0.095
1.907TyrArg: 1.907 ± 0.089
2.219TyrSer: 2.219 ± 0.09
1.784TyrThr: 1.784 ± 0.086
1.6TyrVal: 1.6 ± 0.08
0.505TyrTrp: 0.505 ± 0.054
1.19TyrTyr: 1.19 ± 0.071
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 630 proteins (211832 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski