Amino acid dipepetide frequency for Microbotryum silenes-dioicae

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	9.987AlaAla: 9.987 ± 0.059	1.365AlaCys: 1.365 ± 0.016	4.329AlaAsp: 4.329 ± 0.028	4.867AlaGlu: 4.867 ± 0.032	3.429AlaPhe: 3.429 ± 0.025	5.578AlaGly: 5.578 ± 0.032	2.281AlaHis: 2.281 ± 0.022	4.08AlaIle: 4.08 ± 0.029	4.175AlaLys: 4.175 ± 0.026	9.031AlaLeu: 9.031 ± 0.05	1.941AlaMet: 1.941 ± 0.019	2.855AlaAsn: 2.855 ± 0.023	6.38AlaPro: 6.38 ± 0.042	3.599AlaGln: 3.599 ± 0.027	6.776AlaArg: 6.776 ± 0.04	9.143AlaSer: 9.143 ± 0.061	6.35AlaThr: 6.35 ± 0.04	5.245AlaVal: 5.245 ± 0.029	1.183AlaTrp: 1.183 ± 0.016	2.113AlaTyr: 2.113 ± 0.018	0.0AlaXaa: 0.0 ± 0.0
Cys	1.129CysAla: 1.129 ± 0.017	0.26CysCys: 0.26 ± 0.007	0.786CysAsp: 0.786 ± 0.012	0.565CysGlu: 0.565 ± 0.01	0.59CysPhe: 0.59 ± 0.009	0.955CysGly: 0.955 ± 0.016	0.333CysHis: 0.333 ± 0.007	0.58CysIle: 0.58 ± 0.009	0.583CysLys: 0.583 ± 0.011	1.407CysLeu: 1.407 ± 0.017	0.21CysMet: 0.21 ± 0.006	0.506CysAsn: 0.506 ± 0.012	0.858CysPro: 0.858 ± 0.013	0.501CysGln: 0.501 ± 0.01	0.912CysArg: 0.912 ± 0.012	1.088CysSer: 1.088 ± 0.015	0.756CysThr: 0.756 ± 0.013	0.866CysVal: 0.866 ± 0.012	0.182CysTrp: 0.182 ± 0.005	0.328CysTyr: 0.328 ± 0.007	0.0CysXaa: 0.0 ± 0.0
Asp	5.024AspAla: 5.024 ± 0.026	0.689AspCys: 0.689 ± 0.011	4.923AspAsp: 4.923 ± 0.045	4.396AspGlu: 4.396 ± 0.037	2.059AspPhe: 2.059 ± 0.02	3.733AspGly: 3.733 ± 0.026	1.572AspHis: 1.572 ± 0.017	2.231AspIle: 2.231 ± 0.02	2.115AspLys: 2.115 ± 0.02	5.264AspLeu: 5.264 ± 0.032	0.852AspMet: 0.852 ± 0.013	1.419AspAsn: 1.419 ± 0.013	3.644AspPro: 3.644 ± 0.023	2.121AspGln: 2.121 ± 0.02	3.635AspArg: 3.635 ± 0.028	4.39AspSer: 4.39 ± 0.028	2.715AspThr: 2.715 ± 0.022	3.612AspVal: 3.612 ± 0.023	0.852AspTrp: 0.852 ± 0.01	1.318AspTyr: 1.318 ± 0.015	0.0AspXaa: 0.0 ± 0.0
Glu	5.361GluAla: 5.361 ± 0.035	0.649GluCys: 0.649 ± 0.01	3.61GluAsp: 3.61 ± 0.032	4.703GluGlu: 4.703 ± 0.042	1.729GluPhe: 1.729 ± 0.018	3.954GluGly: 3.954 ± 0.029	1.442GluHis: 1.442 ± 0.016	2.425GluIle: 2.425 ± 0.019	2.444GluLys: 2.444 ± 0.025	5.194GluLeu: 5.194 ± 0.03	1.262GluMet: 1.262 ± 0.014	1.407GluAsn: 1.407 ± 0.014	2.625GluPro: 2.625 ± 0.02	2.371GluGln: 2.371 ± 0.02	4.122GluArg: 4.122 ± 0.031	3.633GluSer: 3.633 ± 0.025	2.891GluThr: 2.891 ± 0.023	3.401GluVal: 3.401 ± 0.026	0.922GluTrp: 0.922 ± 0.014	1.322GluTyr: 1.322 ± 0.013	0.0GluXaa: 0.0 ± 0.0
Phe	3.38PheAla: 3.38 ± 0.022	0.554PheCys: 0.554 ± 0.01	2.457PheAsp: 2.457 ± 0.018	2.026PheGlu: 2.026 ± 0.021	1.374PhePhe: 1.374 ± 0.016	2.631PheGly: 2.631 ± 0.028	0.976PheHis: 0.976 ± 0.014	1.485PheIle: 1.485 ± 0.018	1.482PheLys: 1.482 ± 0.019	3.031PheLeu: 3.031 ± 0.026	0.52PheMet: 0.52 ± 0.01	1.146PheAsn: 1.146 ± 0.015	1.895PhePro: 1.895 ± 0.015	1.214PheGln: 1.214 ± 0.014	1.93PheArg: 1.93 ± 0.018	2.777PheSer: 2.777 ± 0.023	2.269PheThr: 2.269 ± 0.02	2.721PheVal: 2.721 ± 0.023	0.605PheTrp: 0.605 ± 0.01	0.847PheTyr: 0.847 ± 0.012	0.0PheXaa: 0.0 ± 0.0
Gly	5.931GlyAla: 5.931 ± 0.035	0.917GlyCys: 0.917 ± 0.013	3.529GlyAsp: 3.529 ± 0.027	3.582GlyGlu: 3.582 ± 0.026	2.504GlyPhe: 2.504 ± 0.024	5.656GlyGly: 5.656 ± 0.049	1.812GlyHis: 1.812 ± 0.018	2.817GlyIle: 2.817 ± 0.021	3.316GlyLys: 3.316 ± 0.027	5.933GlyLeu: 5.933 ± 0.032	1.366GlyMet: 1.366 ± 0.017	1.918GlyAsn: 1.918 ± 0.019	3.592GlyPro: 3.592 ± 0.032	2.45GlyGln: 2.45 ± 0.022	4.523GlyArg: 4.523 ± 0.026	5.654GlySer: 5.654 ± 0.043	3.949GlyThr: 3.949 ± 0.025	4.032GlyVal: 4.032 ± 0.025	0.962GlyTrp: 0.962 ± 0.011	1.831GlyTyr: 1.831 ± 0.023	0.0GlyXaa: 0.0 ± 0.0
His	2.212HisAla: 2.212 ± 0.02	0.482HisCys: 0.482 ± 0.01	1.365HisAsp: 1.365 ± 0.015	1.196HisGlu: 1.196 ± 0.015	1.115HisPhe: 1.115 ± 0.013	1.728HisGly: 1.728 ± 0.017	1.157HisHis: 1.157 ± 0.018	1.061HisIle: 1.061 ± 0.014	0.854HisLys: 0.854 ± 0.013	2.653HisLeu: 2.653 ± 0.024	0.425HisMet: 0.425 ± 0.007	0.697HisAsn: 0.697 ± 0.011	2.007HisPro: 2.007 ± 0.022	1.128HisGln: 1.128 ± 0.013	2.037HisArg: 2.037 ± 0.02	2.234HisSer: 2.234 ± 0.022	1.28HisThr: 1.28 ± 0.017	1.801HisVal: 1.801 ± 0.016	0.473HisTrp: 0.473 ± 0.009	0.775HisTyr: 0.775 ± 0.011	0.0HisXaa: 0.0 ± 0.0
Ile	4.247IleAla: 4.247 ± 0.029	0.575IleCys: 0.575 ± 0.01	2.9IleAsp: 2.9 ± 0.022	2.62IleGlu: 2.62 ± 0.02	1.556IlePhe: 1.556 ± 0.016	2.682IleGly: 2.682 ± 0.023	0.924IleHis: 0.924 ± 0.012	1.832IleIle: 1.832 ± 0.02	1.946IleLys: 1.946 ± 0.018	3.763IleLeu: 3.763 ± 0.025	0.683IleMet: 0.683 ± 0.01	1.541IleAsn: 1.541 ± 0.017	2.681IlePro: 2.681 ± 0.018	1.482IleGln: 1.482 ± 0.015	2.848IleArg: 2.848 ± 0.025	3.109IleSer: 3.109 ± 0.024	2.362IleThr: 2.362 ± 0.019	2.964IleVal: 2.964 ± 0.021	0.678IleTrp: 0.678 ± 0.009	1.059IleTyr: 1.059 ± 0.015	0.0IleXaa: 0.0 ± 0.0
Lys	4.511LysAla: 4.511 ± 0.03	0.52LysCys: 0.52 ± 0.011	2.168LysAsp: 2.168 ± 0.019	2.731LysGlu: 2.731 ± 0.03	1.176LysPhe: 1.176 ± 0.015	2.982LysGly: 2.982 ± 0.025	1.157LysHis: 1.157 ± 0.014	1.847LysIle: 1.847 ± 0.017	2.668LysLys: 2.668 ± 0.033	4.012LysLeu: 4.012 ± 0.029	0.918LysMet: 0.918 ± 0.011	1.32LysAsn: 1.32 ± 0.016	2.144LysPro: 2.144 ± 0.023	1.502LysGln: 1.502 ± 0.016	3.384LysArg: 3.384 ± 0.026	3.25LysSer: 3.25 ± 0.029	2.629LysThr: 2.629 ± 0.022	2.83LysVal: 2.83 ± 0.023	0.593LysTrp: 0.593 ± 0.009	0.993LysTyr: 0.993 ± 0.015	0.0LysXaa: 0.0 ± 0.0
Leu	9.066LeuAla: 9.066 ± 0.05	1.284LeuCys: 1.284 ± 0.015	5.594LeuAsp: 5.594 ± 0.035	5.28LeuGlu: 5.28 ± 0.033	3.365LeuPhe: 3.365 ± 0.026	6.376LeuGly: 6.376 ± 0.039	2.665LeuHis: 2.665 ± 0.022	3.556LeuIle: 3.556 ± 0.027	3.75LeuLys: 3.75 ± 0.025	8.801LeuLeu: 8.801 ± 0.055	1.559LeuMet: 1.559 ± 0.017	2.837LeuAsn: 2.837 ± 0.021	6.455LeuPro: 6.455 ± 0.039	3.492LeuGln: 3.492 ± 0.028	6.931LeuArg: 6.931 ± 0.04	8.143LeuSer: 8.143 ± 0.042	5.053LeuThr: 5.053 ± 0.027	5.865LeuVal: 5.865 ± 0.032	1.111LeuTrp: 1.111 ± 0.014	2.279LeuTyr: 2.279 ± 0.021	0.0LeuXaa: 0.0 ± 0.0
Met	1.681MetAla: 1.681 ± 0.017	0.215MetCys: 0.215 ± 0.007	1.018MetAsp: 1.018 ± 0.013	0.969MetGlu: 0.969 ± 0.015	0.534MetPhe: 0.534 ± 0.01	1.208MetGly: 1.208 ± 0.014	0.394MetHis: 0.394 ± 0.008	0.841MetIle: 0.841 ± 0.011	0.716MetLys: 0.716 ± 0.01	1.557MetLeu: 1.557 ± 0.016	0.427MetMet: 0.427 ± 0.009	0.546MetAsn: 0.546 ± 0.009	1.147MetPro: 1.147 ± 0.015	0.765MetGln: 0.765 ± 0.012	1.246MetArg: 1.246 ± 0.014	1.677MetSer: 1.677 ± 0.018	1.311MetThr: 1.311 ± 0.015	1.255MetVal: 1.255 ± 0.016	0.239MetTrp: 0.239 ± 0.007	0.487MetTyr: 0.487 ± 0.01	0.0MetXaa: 0.0 ± 0.0
Asn	3.124AsnAla: 3.124 ± 0.019	0.384AsnCys: 0.384 ± 0.011	1.738AsnAsp: 1.738 ± 0.017	1.625AsnGlu: 1.625 ± 0.016	0.953AsnPhe: 0.953 ± 0.014	2.609AsnGly: 2.609 ± 0.024	0.74AsnHis: 0.74 ± 0.01	1.252AsnIle: 1.252 ± 0.015	1.403AsnLys: 1.403 ± 0.015	2.784AsnLeu: 2.784 ± 0.02	0.576AsnMet: 0.576 ± 0.01	1.125AsnAsn: 1.125 ± 0.018	1.933AsnPro: 1.933 ± 0.02	1.138AsnGln: 1.138 ± 0.014	2.098AsnArg: 2.098 ± 0.017	2.481AsnSer: 2.481 ± 0.023	1.723AsnThr: 1.723 ± 0.019	1.884AsnVal: 1.884 ± 0.018	0.456AsnTrp: 0.456 ± 0.008	0.726AsnTyr: 0.726 ± 0.013	0.0AsnXaa: 0.0 ± 0.0
Pro	6.041ProAla: 6.041 ± 0.041	0.703ProCys: 0.703 ± 0.011	3.113ProAsp: 3.113 ± 0.03	2.962ProGlu: 2.962 ± 0.022	2.148ProPhe: 2.148 ± 0.017	3.602ProGly: 3.602 ± 0.029	1.603ProHis: 1.603 ± 0.015	2.671ProIle: 2.671 ± 0.024	2.631ProLys: 2.631 ± 0.022	5.602ProLeu: 5.602 ± 0.032	1.043ProMet: 1.043 ± 0.013	2.048ProAsn: 2.048 ± 0.019	5.964ProPro: 5.964 ± 0.063	2.158ProGln: 2.158 ± 0.02	4.081ProArg: 4.081 ± 0.031	7.539ProSer: 7.539 ± 0.056	5.064ProThr: 5.064 ± 0.034	3.923ProVal: 3.923 ± 0.029	0.558ProTrp: 0.558 ± 0.01	1.272ProTyr: 1.272 ± 0.013	0.0ProXaa: 0.0 ± 0.0
Gln	3.952GlnAla: 3.952 ± 0.028	0.449GlnCys: 0.449 ± 0.008	1.783GlnAsp: 1.783 ± 0.015	2.009GlnGlu: 2.009 ± 0.02	1.002GlnPhe: 1.002 ± 0.015	2.709GlnGly: 2.709 ± 0.024	1.318GlnHis: 1.318 ± 0.015	1.534GlnIle: 1.534 ± 0.016	1.343GlnLys: 1.343 ± 0.015	3.464GlnLeu: 3.464 ± 0.025	0.66GlnMet: 0.66 ± 0.009	1.039GlnAsn: 1.039 ± 0.012	2.276GlnPro: 2.276 ± 0.021	2.27GlnGln: 2.27 ± 0.048	2.847GlnArg: 2.847 ± 0.019	2.849GlnSer: 2.849 ± 0.023	2.091GlnThr: 2.091 ± 0.02	2.343GlnVal: 2.343 ± 0.019	0.46GlnTrp: 0.46 ± 0.009	0.869GlnTyr: 0.869 ± 0.012	0.0GlnXaa: 0.0 ± 0.0
Arg	6.179ArgAla: 6.179 ± 0.038	0.99ArgCys: 0.99 ± 0.012	3.504ArgAsp: 3.504 ± 0.028	3.657ArgGlu: 3.657 ± 0.031	2.593ArgPhe: 2.593 ± 0.021	4.147ArgGly: 4.147 ± 0.03	1.98ArgHis: 1.98 ± 0.018	3.117ArgIle: 3.117 ± 0.023	3.065ArgLys: 3.065 ± 0.023	7.199ArgLeu: 7.199 ± 0.042	1.373ArgMet: 1.373 ± 0.017	2.098ArgAsn: 2.098 ± 0.018	4.266ArgPro: 4.266 ± 0.028	2.58ArgGln: 2.58 ± 0.019	5.945ArgArg: 5.945 ± 0.044	6.393ArgSer: 6.393 ± 0.042	4.038ArgThr: 4.038 ± 0.026	4.097ArgVal: 4.097 ± 0.027	1.097ArgTrp: 1.097 ± 0.013	1.74ArgTyr: 1.74 ± 0.017	0.0ArgXaa: 0.0 ± 0.0
Ser	7.999SerAla: 7.999 ± 0.049	1.097SerCys: 1.097 ± 0.015	4.635SerAsp: 4.635 ± 0.03	3.72SerGlu: 3.72 ± 0.025	3.036SerPhe: 3.036 ± 0.027	5.39SerGly: 5.39 ± 0.036	2.274SerHis: 2.274 ± 0.022	4.068SerIle: 4.068 ± 0.027	3.817SerLys: 3.817 ± 0.024	8.273SerLeu: 8.273 ± 0.039	1.508SerMet: 1.508 ± 0.016	2.948SerAsn: 2.948 ± 0.024	6.384SerPro: 6.384 ± 0.058	2.885SerGln: 2.885 ± 0.024	5.847SerArg: 5.847 ± 0.036	11.341SerSer: 11.341 ± 0.101	7.673SerThr: 7.673 ± 0.056	4.369SerVal: 4.369 ± 0.029	1.106SerTrp: 1.106 ± 0.015	1.692SerTyr: 1.692 ± 0.017	0.0SerXaa: 0.0 ± 0.0
Thr	5.577ThrAla: 5.577 ± 0.03	0.864ThrCys: 0.864 ± 0.015	2.9ThrAsp: 2.9 ± 0.022	2.769ThrGlu: 2.769 ± 0.024	2.324ThrPhe: 2.324 ± 0.019	3.925ThrGly: 3.925 ± 0.028	1.567ThrHis: 1.567 ± 0.016	2.765ThrIle: 2.765 ± 0.024	2.627ThrLys: 2.627 ± 0.024	5.768ThrLeu: 5.768 ± 0.029	1.101ThrMet: 1.101 ± 0.015	2.001ThrAsn: 2.001 ± 0.018	4.992ThrPro: 4.992 ± 0.039	1.994ThrGln: 1.994 ± 0.017	4.182ThrArg: 4.182 ± 0.026	6.759ThrSer: 6.759 ± 0.049	5.183ThrThr: 5.183 ± 0.044	3.414ThrVal: 3.414 ± 0.025	0.81ThrTrp: 0.81 ± 0.013	1.307ThrTyr: 1.307 ± 0.013	0.0ThrXaa: 0.0 ± 0.0
Val	6.135ValAla: 6.135 ± 0.038	0.8ValCys: 0.8 ± 0.014	3.898ValAsp: 3.898 ± 0.027	3.839ValGlu: 3.839 ± 0.03	2.436ValPhe: 2.436 ± 0.027	3.874ValGly: 3.874 ± 0.028	1.518ValHis: 1.518 ± 0.016	2.396ValIle: 2.396 ± 0.02	2.886ValLys: 2.886 ± 0.023	5.903ValLeu: 5.903 ± 0.031	1.133ValMet: 1.133 ± 0.014	1.947ValAsn: 1.947 ± 0.018	3.68ValPro: 3.68 ± 0.023	2.301ValGln: 2.301 ± 0.019	4.037ValArg: 4.037 ± 0.025	4.566ValSer: 4.566 ± 0.029	3.17ValThr: 3.17 ± 0.023	4.504ValVal: 4.504 ± 0.033	0.938ValTrp: 0.938 ± 0.014	1.409ValTyr: 1.409 ± 0.015	0.0ValXaa: 0.0 ± 0.0
Trp	1.116TrpAla: 1.116 ± 0.013	0.218TrpCys: 0.218 ± 0.006	0.82TrpAsp: 0.82 ± 0.012	0.736TrpGlu: 0.736 ± 0.011	0.418TrpPhe: 0.418 ± 0.008	0.928TrpGly: 0.928 ± 0.014	0.334TrpHis: 0.334 ± 0.007	0.77TrpIle: 0.77 ± 0.011	0.636TrpLys: 0.636 ± 0.01	1.223TrpLeu: 1.223 ± 0.013	0.295TrpMet: 0.295 ± 0.007	0.573TrpAsn: 0.573 ± 0.009	0.623TrpPro: 0.623 ± 0.01	0.509TrpGln: 0.509 ± 0.008	1.04TrpArg: 1.04 ± 0.013	1.2TrpSer: 1.2 ± 0.013	0.945TrpThr: 0.945 ± 0.013	0.815TrpVal: 0.815 ± 0.012	0.208TrpTrp: 0.208 ± 0.006	0.35TrpTyr: 0.35 ± 0.006	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.058TyrAla: 2.058 ± 0.02	0.381TyrCys: 0.381 ± 0.007	1.494TyrAsp: 1.494 ± 0.017	1.217TyrGlu: 1.217 ± 0.014	0.978TyrPhe: 0.978 ± 0.013	1.608TyrGly: 1.608 ± 0.02	0.634TyrHis: 0.634 ± 0.01	1.124TyrIle: 1.124 ± 0.015	0.876TyrLys: 0.876 ± 0.013	2.597TyrLeu: 2.597 ± 0.025	0.381TyrMet: 0.381 ± 0.008	0.782TyrAsn: 0.782 ± 0.014	1.181TyrPro: 1.181 ± 0.013	0.806TyrGln: 0.806 ± 0.012	1.637TyrArg: 1.637 ± 0.014	1.837TyrSer: 1.837 ± 0.016	1.378TyrThr: 1.378 ± 0.015	1.43TyrVal: 1.43 ± 0.018	0.322TyrTrp: 0.322 ± 0.007	0.578TyrTyr: 0.578 ± 0.01	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 12674 proteins (6622593 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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