Amino acid dipepetide frequency for Hoeflea halophila

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	15.72AlaAla: 15.72 ± 0.173	1.006AlaCys: 1.006 ± 0.028	6.904AlaAsp: 6.904 ± 0.094	7.84AlaGlu: 7.84 ± 0.084	4.419AlaPhe: 4.419 ± 0.066	10.583AlaGly: 10.583 ± 0.11	2.182AlaHis: 2.182 ± 0.042	6.597AlaIle: 6.597 ± 0.079	4.011AlaLys: 4.011 ± 0.069	12.375AlaLeu: 12.375 ± 0.121	3.748AlaMet: 3.748 ± 0.055	3.055AlaAsn: 3.055 ± 0.05	4.988AlaPro: 4.988 ± 0.082	3.575AlaGln: 3.575 ± 0.054	8.119AlaArg: 8.119 ± 0.089	6.735AlaSer: 6.735 ± 0.07	5.617AlaThr: 5.617 ± 0.068	8.267AlaVal: 8.267 ± 0.094	1.448AlaTrp: 1.448 ± 0.038	2.467AlaTyr: 2.467 ± 0.046	0.0AlaXaa: 0.0 ± 0.0
Cys	0.914CysAla: 0.914 ± 0.031	0.103CysCys: 0.103 ± 0.01	0.52CysAsp: 0.52 ± 0.02	0.478CysGlu: 0.478 ± 0.021	0.371CysPhe: 0.371 ± 0.018	0.942CysGly: 0.942 ± 0.031	0.256CysHis: 0.256 ± 0.015	0.39CysIle: 0.39 ± 0.019	0.23CysLys: 0.23 ± 0.013	0.812CysLeu: 0.812 ± 0.027	0.186CysMet: 0.186 ± 0.013	0.219CysAsn: 0.219 ± 0.013	0.441CysPro: 0.441 ± 0.022	0.223CysGln: 0.223 ± 0.014	0.577CysArg: 0.577 ± 0.023	0.468CysSer: 0.468 ± 0.021	0.421CysThr: 0.421 ± 0.019	0.587CysVal: 0.587 ± 0.023	0.103CysTrp: 0.103 ± 0.01	0.199CysTyr: 0.199 ± 0.013	0.0CysXaa: 0.0 ± 0.0
Asp	6.631AspAla: 6.631 ± 0.084	0.516AspCys: 0.516 ± 0.021	3.172AspAsp: 3.172 ± 0.068	3.74AspGlu: 3.74 ± 0.054	2.341AspPhe: 2.341 ± 0.04	5.135AspGly: 5.135 ± 0.082	1.383AspHis: 1.383 ± 0.033	3.381AspIle: 3.381 ± 0.053	1.915AspLys: 1.915 ± 0.04	5.758AspLeu: 5.758 ± 0.076	1.633AspMet: 1.633 ± 0.035	1.533AspAsn: 1.533 ± 0.041	3.556AspPro: 3.556 ± 0.062	1.826AspGln: 1.826 ± 0.04	4.071AspArg: 4.071 ± 0.065	2.373AspSer: 2.373 ± 0.051	2.814AspThr: 2.814 ± 0.048	4.045AspVal: 4.045 ± 0.048	0.953AspTrp: 0.953 ± 0.029	1.557AspTyr: 1.557 ± 0.039	0.0AspXaa: 0.0 ± 0.0
Glu	7.924GluAla: 7.924 ± 0.09	0.387GluCys: 0.387 ± 0.019	3.146GluAsp: 3.146 ± 0.052	3.439GluGlu: 3.439 ± 0.066	1.95GluPhe: 1.95 ± 0.042	4.366GluGly: 4.366 ± 0.065	1.179GluHis: 1.179 ± 0.033	4.032GluIle: 4.032 ± 0.054	2.575GluLys: 2.575 ± 0.053	5.67GluLeu: 5.67 ± 0.076	1.781GluMet: 1.781 ± 0.037	1.945GluAsn: 1.945 ± 0.043	2.765GluPro: 2.765 ± 0.054	2.172GluGln: 2.172 ± 0.053	4.595GluArg: 4.595 ± 0.07	2.651GluSer: 2.651 ± 0.045	4.027GluThr: 4.027 ± 0.067	4.005GluVal: 4.005 ± 0.055	0.699GluTrp: 0.699 ± 0.027	1.029GluTyr: 1.029 ± 0.028	0.0GluXaa: 0.0 ± 0.0
Phe	4.572PheAla: 4.572 ± 0.07	0.447PheCys: 0.447 ± 0.018	2.757PheAsp: 2.757 ± 0.053	2.389PheGlu: 2.389 ± 0.044	1.525PhePhe: 1.525 ± 0.046	3.734PheGly: 3.734 ± 0.059	0.757PheHis: 0.757 ± 0.022	1.982PheIle: 1.982 ± 0.045	1.102PheLys: 1.102 ± 0.029	3.498PheLeu: 3.498 ± 0.067	0.928PheMet: 0.928 ± 0.028	1.141PheAsn: 1.141 ± 0.027	1.558PhePro: 1.558 ± 0.038	0.973PheGln: 0.973 ± 0.028	2.225PheArg: 2.225 ± 0.042	2.522PheSer: 2.522 ± 0.047	2.031PheThr: 2.031 ± 0.044	2.879PheVal: 2.879 ± 0.054	0.555PheTrp: 0.555 ± 0.025	0.889PheTyr: 0.889 ± 0.027	0.0PheXaa: 0.0 ± 0.0
Gly	8.77GlyAla: 8.77 ± 0.094	0.835GlyCys: 0.835 ± 0.028	4.595GlyAsp: 4.595 ± 0.063	5.142GlyGlu: 5.142 ± 0.066	3.862GlyPhe: 3.862 ± 0.062	7.171GlyGly: 7.171 ± 0.1	1.902GlyHis: 1.902 ± 0.041	4.946GlyIle: 4.946 ± 0.066	3.621GlyLys: 3.621 ± 0.064	8.927GlyLeu: 8.927 ± 0.1	2.608GlyMet: 2.608 ± 0.048	2.279GlyAsn: 2.279 ± 0.043	3.247GlyPro: 3.247 ± 0.053	2.809GlyGln: 2.809 ± 0.046	5.613GlyArg: 5.613 ± 0.074	4.91GlySer: 4.91 ± 0.067	4.384GlyThr: 4.384 ± 0.069	6.185GlyVal: 6.185 ± 0.076	1.322GlyTrp: 1.322 ± 0.034	2.341GlyTyr: 2.341 ± 0.049	0.0GlyXaa: 0.0 ± 0.0
His	2.201HisAla: 2.201 ± 0.043	0.255HisCys: 0.255 ± 0.016	1.223HisAsp: 1.223 ± 0.039	1.116HisGlu: 1.116 ± 0.036	0.832HisPhe: 0.832 ± 0.028	1.998HisGly: 1.998 ± 0.045	0.585HisHis: 0.585 ± 0.025	0.972HisIle: 0.972 ± 0.028	0.574HisLys: 0.574 ± 0.019	1.967HisLeu: 1.967 ± 0.044	0.522HisMet: 0.522 ± 0.024	0.484HisAsn: 0.484 ± 0.019	1.251HisPro: 1.251 ± 0.026	0.582HisGln: 0.582 ± 0.021	1.302HisArg: 1.302 ± 0.033	1.042HisSer: 1.042 ± 0.033	0.864HisThr: 0.864 ± 0.026	1.58HisVal: 1.58 ± 0.036	0.287HisTrp: 0.287 ± 0.017	0.582HisTyr: 0.582 ± 0.024	0.0HisXaa: 0.0 ± 0.0
Ile	7.617IleAla: 7.617 ± 0.096	0.575IleCys: 0.575 ± 0.023	3.814IleAsp: 3.814 ± 0.057	3.87IleGlu: 3.87 ± 0.065	1.88IlePhe: 1.88 ± 0.048	5.207IleGly: 5.207 ± 0.065	1.005IleHis: 1.005 ± 0.031	2.888IleIle: 2.888 ± 0.054	1.717IleLys: 1.717 ± 0.04	4.701IleLeu: 4.701 ± 0.077	1.239IleMet: 1.239 ± 0.029	1.744IleAsn: 1.744 ± 0.042	2.379IlePro: 2.379 ± 0.052	1.202IleGln: 1.202 ± 0.034	3.592IleArg: 3.592 ± 0.058	3.567IleSer: 3.567 ± 0.056	2.913IleThr: 2.913 ± 0.054	4.184IleVal: 4.184 ± 0.063	0.662IleTrp: 0.662 ± 0.026	1.225IleTyr: 1.225 ± 0.038	0.0IleXaa: 0.0 ± 0.0
Lys	4.5LysAla: 4.5 ± 0.07	0.182LysCys: 0.182 ± 0.013	1.836LysAsp: 1.836 ± 0.037	1.572LysGlu: 1.572 ± 0.046	0.967LysPhe: 0.967 ± 0.029	2.753LysGly: 2.753 ± 0.052	0.677LysHis: 0.677 ± 0.027	2.079LysIle: 2.079 ± 0.043	1.398LysLys: 1.398 ± 0.04	3.526LysLeu: 3.526 ± 0.055	0.921LysMet: 0.921 ± 0.03	0.99LysAsn: 0.99 ± 0.028	2.314LysPro: 2.314 ± 0.057	1.151LysGln: 1.151 ± 0.032	2.42LysArg: 2.42 ± 0.052	2.203LysSer: 2.203 ± 0.049	2.233LysThr: 2.233 ± 0.049	2.455LysVal: 2.455 ± 0.05	0.369LysTrp: 0.369 ± 0.017	0.677LysTyr: 0.677 ± 0.028	0.0LysXaa: 0.0 ± 0.0
Leu	12.514LeuAla: 12.514 ± 0.122	0.867LeuCys: 0.867 ± 0.025	5.853LeuAsp: 5.853 ± 0.078	5.751LeuGlu: 5.751 ± 0.074	3.74LeuPhe: 3.74 ± 0.073	8.082LeuGly: 8.082 ± 0.092	1.656LeuHis: 1.656 ± 0.042	5.453LeuIle: 5.453 ± 0.084	3.895LeuLys: 3.895 ± 0.061	8.799LeuLeu: 8.799 ± 0.123	2.574LeuMet: 2.574 ± 0.054	2.74LeuAsn: 2.74 ± 0.049	5.094LeuPro: 5.094 ± 0.076	2.504LeuGln: 2.504 ± 0.045	5.743LeuArg: 5.743 ± 0.072	6.797LeuSer: 6.797 ± 0.075	5.406LeuThr: 5.406 ± 0.077	7.459LeuVal: 7.459 ± 0.094	1.066LeuTrp: 1.066 ± 0.036	2.02LeuTyr: 2.02 ± 0.039	0.0LeuXaa: 0.0 ± 0.0
Met	3.452MetAla: 3.452 ± 0.052	0.171MetCys: 0.171 ± 0.011	1.29MetAsp: 1.29 ± 0.03	1.335MetGlu: 1.335 ± 0.033	0.842MetPhe: 0.842 ± 0.025	2.006MetGly: 2.006 ± 0.046	0.491MetHis: 0.491 ± 0.021	1.73MetIle: 1.73 ± 0.037	1.144MetLys: 1.144 ± 0.035	2.663MetLeu: 2.663 ± 0.053	0.823MetMet: 0.823 ± 0.027	0.932MetAsn: 0.932 ± 0.029	1.534MetPro: 1.534 ± 0.035	0.971MetGln: 0.971 ± 0.031	1.872MetArg: 1.872 ± 0.038	1.928MetSer: 1.928 ± 0.035	2.054MetThr: 2.054 ± 0.046	1.913MetVal: 1.913 ± 0.038	0.217MetTrp: 0.217 ± 0.013	0.338MetTyr: 0.338 ± 0.015	0.0MetXaa: 0.0 ± 0.0
Asn	3.267AsnAla: 3.267 ± 0.052	0.252AsnCys: 0.252 ± 0.017	1.478AsnAsp: 1.478 ± 0.035	1.458AsnGlu: 1.458 ± 0.036	1.05AsnPhe: 1.05 ± 0.031	2.58AsnGly: 2.58 ± 0.045	0.565AsnHis: 0.565 ± 0.022	1.48AsnIle: 1.48 ± 0.034	0.827AsnLys: 0.827 ± 0.027	2.628AsnLeu: 2.628 ± 0.046	0.727AsnMet: 0.727 ± 0.023	0.788AsnAsn: 0.788 ± 0.026	1.942AsnPro: 1.942 ± 0.044	0.893AsnGln: 0.893 ± 0.027	2.023AsnArg: 2.023 ± 0.042	1.531AsnSer: 1.531 ± 0.038	1.351AsnThr: 1.351 ± 0.034	1.924AsnVal: 1.924 ± 0.039	0.47AsnTrp: 0.47 ± 0.022	0.725AsnTyr: 0.725 ± 0.026	0.0AsnXaa: 0.0 ± 0.0
Pro	5.71ProAla: 5.71 ± 0.095	0.318ProCys: 0.318 ± 0.016	3.811ProAsp: 3.811 ± 0.066	3.969ProGlu: 3.969 ± 0.064	1.972ProPhe: 1.972 ± 0.044	4.592ProGly: 4.592 ± 0.069	1.007ProHis: 1.007 ± 0.031	2.068ProIle: 2.068 ± 0.041	1.644ProLys: 1.644 ± 0.035	4.459ProLeu: 4.459 ± 0.065	1.197ProMet: 1.197 ± 0.032	1.224ProAsn: 1.224 ± 0.035	1.993ProPro: 1.993 ± 0.049	1.495ProGln: 1.495 ± 0.037	2.516ProArg: 2.516 ± 0.047	2.663ProSer: 2.663 ± 0.053	2.083ProThr: 2.083 ± 0.041	4.505ProVal: 4.505 ± 0.06	0.638ProTrp: 0.638 ± 0.025	1.142ProTyr: 1.142 ± 0.033	0.0ProXaa: 0.0 ± 0.0
Gln	3.954GlnAla: 3.954 ± 0.057	0.195GlnCys: 0.195 ± 0.013	1.443GlnAsp: 1.443 ± 0.036	1.478GlnGlu: 1.478 ± 0.034	1.081GlnPhe: 1.081 ± 0.034	2.17GlnGly: 2.17 ± 0.041	0.603GlnHis: 0.603 ± 0.024	1.877GlnIle: 1.877 ± 0.042	1.12GlnLys: 1.12 ± 0.028	2.902GlnLeu: 2.902 ± 0.054	0.976GlnMet: 0.976 ± 0.028	0.849GlnAsn: 0.849 ± 0.028	1.671GlnPro: 1.671 ± 0.042	1.069GlnGln: 1.069 ± 0.034	2.028GlnArg: 2.028 ± 0.049	2.012GlnSer: 2.012 ± 0.042	1.836GlnThr: 1.836 ± 0.037	2.177GlnVal: 2.177 ± 0.044	0.372GlnTrp: 0.372 ± 0.017	0.537GlnTyr: 0.537 ± 0.021	0.0GlnXaa: 0.0 ± 0.0
Arg	7.035ArgAla: 7.035 ± 0.085	0.43ArgCys: 0.43 ± 0.02	3.84ArgAsp: 3.84 ± 0.066	3.997ArgGlu: 3.997 ± 0.063	2.845ArgPhe: 2.845 ± 0.047	4.339ArgGly: 4.339 ± 0.062	1.61ArgHis: 1.61 ± 0.039	4.062ArgIle: 4.062 ± 0.065	2.594ArgLys: 2.594 ± 0.049	7.122ArgLeu: 7.122 ± 0.085	1.961ArgMet: 1.961 ± 0.041	1.977ArgAsn: 1.977 ± 0.044	3.098ArgPro: 3.098 ± 0.056	2.456ArgGln: 2.456 ± 0.046	4.659ArgArg: 4.659 ± 0.075	3.758ArgSer: 3.758 ± 0.054	3.251ArgThr: 3.251 ± 0.05	4.221ArgVal: 4.221 ± 0.063	0.788ArgTrp: 0.788 ± 0.025	1.552ArgTyr: 1.552 ± 0.043	0.0ArgXaa: 0.0 ± 0.0
Ser	6.51SerAla: 6.51 ± 0.072	0.452SerCys: 0.452 ± 0.021	3.421SerAsp: 3.421 ± 0.05	3.393SerGlu: 3.393 ± 0.051	2.4SerPhe: 2.4 ± 0.043	6.193SerGly: 6.193 ± 0.069	1.207SerHis: 1.207 ± 0.039	3.123SerIle: 3.123 ± 0.051	1.905SerLys: 1.905 ± 0.046	5.609SerLeu: 5.609 ± 0.072	1.585SerMet: 1.585 ± 0.035	1.613SerAsn: 1.613 ± 0.037	2.727SerPro: 2.727 ± 0.05	1.852SerGln: 1.852 ± 0.041	3.757SerArg: 3.757 ± 0.061	3.313SerSer: 3.313 ± 0.056	2.871SerThr: 2.871 ± 0.056	4.316SerVal: 4.316 ± 0.058	0.775SerTrp: 0.775 ± 0.024	1.388SerTyr: 1.388 ± 0.034	0.0SerXaa: 0.0 ± 0.0
Thr	6.264ThrAla: 6.264 ± 0.079	0.437ThrCys: 0.437 ± 0.021	2.985ThrAsp: 2.985 ± 0.05	2.998ThrGlu: 2.998 ± 0.047	1.811ThrPhe: 1.811 ± 0.035	5.547ThrGly: 5.547 ± 0.062	1.006ThrHis: 1.006 ± 0.029	2.967ThrIle: 2.967 ± 0.054	1.45ThrLys: 1.45 ± 0.035	5.453ThrLeu: 5.453 ± 0.076	1.353ThrMet: 1.353 ± 0.037	1.32ThrAsn: 1.32 ± 0.036	3.114ThrPro: 3.114 ± 0.05	1.399ThrGln: 1.399 ± 0.036	3.335ThrArg: 3.335 ± 0.056	2.958ThrSer: 2.958 ± 0.055	2.691ThrThr: 2.691 ± 0.051	4.302ThrVal: 4.302 ± 0.066	0.594ThrTrp: 0.594 ± 0.02	1.132ThrTyr: 1.132 ± 0.031	0.0ThrXaa: 0.0 ± 0.0
Val	8.636ValAla: 8.636 ± 0.094	0.625ValCys: 0.625 ± 0.022	4.12ValAsp: 4.12 ± 0.063	4.593ValGlu: 4.593 ± 0.065	3.061ValPhe: 3.061 ± 0.057	5.164ValGly: 5.164 ± 0.067	1.325ValHis: 1.325 ± 0.032	4.402ValIle: 4.402 ± 0.071	2.324ValLys: 2.324 ± 0.051	7.336ValLeu: 7.336 ± 0.091	2.046ValMet: 2.046 ± 0.041	2.08ValAsn: 2.08 ± 0.04	3.54ValPro: 3.54 ± 0.054	1.888ValGln: 1.888 ± 0.045	4.556ValArg: 4.556 ± 0.064	4.862ValSer: 4.862 ± 0.065	4.477ValThr: 4.477 ± 0.056	5.493ValVal: 5.493 ± 0.087	0.889ValTrp: 0.889 ± 0.029	1.464ValTyr: 1.464 ± 0.036	0.0ValXaa: 0.0 ± 0.0
Trp	1.152TrpAla: 1.152 ± 0.031	0.13TrpCys: 0.13 ± 0.009	0.68TrpAsp: 0.68 ± 0.027	0.538TrpGlu: 0.538 ± 0.021	0.549TrpPhe: 0.549 ± 0.022	0.831TrpGly: 0.831 ± 0.029	0.324TrpHis: 0.324 ± 0.018	0.63TrpIle: 0.63 ± 0.026	0.496TrpLys: 0.496 ± 0.017	1.579TrpLeu: 1.579 ± 0.039	0.404TrpMet: 0.404 ± 0.02	0.43TrpAsn: 0.43 ± 0.019	0.696TrpPro: 0.696 ± 0.026	0.549TrpGln: 0.549 ± 0.023	0.991TrpArg: 0.991 ± 0.031	0.806TrpSer: 0.806 ± 0.025	0.649TrpThr: 0.649 ± 0.024	0.798TrpVal: 0.798 ± 0.027	0.215TrpTrp: 0.215 ± 0.014	0.279TrpTyr: 0.279 ± 0.013	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.314TyrAla: 2.314 ± 0.042	0.254TyrCys: 0.254 ± 0.014	1.447TyrAsp: 1.447 ± 0.037	1.242TyrGlu: 1.242 ± 0.031	0.96TyrPhe: 0.96 ± 0.03	2.073TyrGly: 2.073 ± 0.042	0.498TyrHis: 0.498 ± 0.021	0.923TyrIle: 0.923 ± 0.026	0.68TyrLys: 0.68 ± 0.027	2.229TyrLeu: 2.229 ± 0.046	0.496TyrMet: 0.496 ± 0.02	0.619TyrAsn: 0.619 ± 0.024	1.098TyrPro: 1.098 ± 0.029	0.76TyrGln: 0.76 ± 0.025	1.602TyrArg: 1.602 ± 0.039	1.311TyrSer: 1.311 ± 0.034	1.144TyrThr: 1.144 ± 0.029	1.589TyrVal: 1.589 ± 0.034	0.305TyrTrp: 0.305 ± 0.016	0.574TyrTyr: 0.574 ± 0.023	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3883 proteins (1229019 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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