Amino acid dipepetide frequency for Sphaerochaeta globosa (strain ATCC BAA-1886 / DSM 22777 / Buddy) (Spirochaeta sp. (strain Buddy))

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
6.364AlaAla: 6.364 ± 0.107
1.061AlaCys: 1.061 ± 0.033
3.65AlaAsp: 3.65 ± 0.061
4.205AlaGlu: 4.205 ± 0.065
3.859AlaPhe: 3.859 ± 0.065
5.278AlaGly: 5.278 ± 0.078
1.392AlaHis: 1.392 ± 0.038
5.702AlaIle: 5.702 ± 0.085
5.031AlaLys: 5.031 ± 0.072
9.932AlaLeu: 9.932 ± 0.117
2.647AlaMet: 2.647 ± 0.057
2.873AlaAsn: 2.873 ± 0.05
2.306AlaPro: 2.306 ± 0.058
3.265AlaGln: 3.265 ± 0.055
3.187AlaArg: 3.187 ± 0.054
5.881AlaSer: 5.881 ± 0.086
4.315AlaThr: 4.315 ± 0.074
5.757AlaVal: 5.757 ± 0.073
0.879AlaTrp: 0.879 ± 0.035
3.056AlaTyr: 3.056 ± 0.061
0.0AlaXaa: 0.0 ± 0.0
Cys
0.886CysAla: 0.886 ± 0.03
0.181CysCys: 0.181 ± 0.014
0.74CysAsp: 0.74 ± 0.03
0.734CysGlu: 0.734 ± 0.028
0.547CysPhe: 0.547 ± 0.024
1.037CysGly: 1.037 ± 0.036
0.273CysHis: 0.273 ± 0.016
0.856CysIle: 0.856 ± 0.026
0.643CysLys: 0.643 ± 0.026
1.143CysLeu: 1.143 ± 0.04
0.358CysMet: 0.358 ± 0.021
0.471CysAsn: 0.471 ± 0.022
0.587CysPro: 0.587 ± 0.03
0.332CysGln: 0.332 ± 0.019
0.533CysArg: 0.533 ± 0.023
0.958CysSer: 0.958 ± 0.033
0.786CysThr: 0.786 ± 0.031
0.667CysVal: 0.667 ± 0.028
0.111CysTrp: 0.111 ± 0.012
0.388CysTyr: 0.388 ± 0.02
0.0CysXaa: 0.0 ± 0.0
Asp
4.31AspAla: 4.31 ± 0.065
0.59AspCys: 0.59 ± 0.026
2.394AspAsp: 2.394 ± 0.056
3.78AspGlu: 3.78 ± 0.081
2.418AspPhe: 2.418 ± 0.053
3.765AspGly: 3.765 ± 0.066
0.998AspHis: 0.998 ± 0.036
3.437AspIle: 3.437 ± 0.065
2.409AspLys: 2.409 ± 0.05
5.179AspLeu: 5.179 ± 0.075
1.258AspMet: 1.258 ± 0.039
1.559AspAsn: 1.559 ± 0.045
2.156AspPro: 2.156 ± 0.049
1.822AspGln: 1.822 ± 0.05
2.457AspArg: 2.457 ± 0.066
3.202AspSer: 3.202 ± 0.062
2.802AspThr: 2.802 ± 0.056
3.315AspVal: 3.315 ± 0.063
0.688AspTrp: 0.688 ± 0.027
1.83AspTyr: 1.83 ± 0.047
0.0AspXaa: 0.0 ± 0.0
Glu
5.356GluAla: 5.356 ± 0.075
0.479GluCys: 0.479 ± 0.024
2.978GluAsp: 2.978 ± 0.057
4.662GluGlu: 4.662 ± 0.116
1.976GluPhe: 1.976 ± 0.046
4.404GluGly: 4.404 ± 0.07
1.508GluHis: 1.508 ± 0.04
3.702GluIle: 3.702 ± 0.066
4.005GluLys: 4.005 ± 0.072
6.003GluLeu: 6.003 ± 0.093
1.766GluMet: 1.766 ± 0.036
2.542GluAsn: 2.542 ± 0.055
1.766GluPro: 1.766 ± 0.045
3.287GluGln: 3.287 ± 0.061
3.208GluArg: 3.208 ± 0.063
3.419GluSer: 3.419 ± 0.071
3.162GluThr: 3.162 ± 0.051
4.307GluVal: 4.307 ± 0.07
0.447GluTrp: 0.447 ± 0.022
2.055GluTyr: 2.055 ± 0.048
0.0GluXaa: 0.0 ± 0.0
Phe
3.769PheAla: 3.769 ± 0.069
0.702PheCys: 0.702 ± 0.027
2.6PheAsp: 2.6 ± 0.05
2.536PheGlu: 2.536 ± 0.048
2.396PhePhe: 2.396 ± 0.059
3.372PheGly: 3.372 ± 0.06
0.797PheHis: 0.797 ± 0.029
3.069PheIle: 3.069 ± 0.053
1.896PheLys: 1.896 ± 0.049
4.852PheLeu: 4.852 ± 0.085
1.121PheMet: 1.121 ± 0.038
1.725PheAsn: 1.725 ± 0.043
1.853PhePro: 1.853 ± 0.043
1.252PheGln: 1.252 ± 0.034
1.709PheArg: 1.709 ± 0.046
4.228PheSer: 4.228 ± 0.072
2.839PheThr: 2.839 ± 0.059
2.867PheVal: 2.867 ± 0.06
0.501PheTrp: 0.501 ± 0.028
1.504PheTyr: 1.504 ± 0.041
0.0PheXaa: 0.0 ± 0.0
Gly
4.811GlyAla: 4.811 ± 0.084
1.053GlyCys: 1.053 ± 0.036
3.004GlyAsp: 3.004 ± 0.06
3.711GlyGlu: 3.711 ± 0.058
3.491GlyPhe: 3.491 ± 0.062
4.891GlyGly: 4.891 ± 0.086
1.184GlyHis: 1.184 ± 0.04
5.461GlyIle: 5.461 ± 0.082
4.591GlyLys: 4.591 ± 0.068
7.175GlyLeu: 7.175 ± 0.095
2.329GlyMet: 2.329 ± 0.051
2.577GlyAsn: 2.577 ± 0.054
2.028GlyPro: 2.028 ± 0.045
2.194GlyGln: 2.194 ± 0.046
3.137GlyArg: 3.137 ± 0.057
5.117GlySer: 5.117 ± 0.077
4.238GlyThr: 4.238 ± 0.081
4.822GlyVal: 4.822 ± 0.082
0.846GlyTrp: 0.846 ± 0.035
3.097GlyTyr: 3.097 ± 0.056
0.0GlyXaa: 0.0 ± 0.0
His
1.597HisAla: 1.597 ± 0.044
0.293HisCys: 0.293 ± 0.017
0.991HisAsp: 0.991 ± 0.032
1.019HisGlu: 1.019 ± 0.033
0.965HisPhe: 0.965 ± 0.031
1.26HisGly: 1.26 ± 0.039
0.543HisHis: 0.543 ± 0.025
1.378HisIle: 1.378 ± 0.036
0.786HisLys: 0.786 ± 0.03
2.203HisLeu: 2.203 ± 0.055
0.499HisMet: 0.499 ± 0.022
0.627HisAsn: 0.627 ± 0.023
1.132HisPro: 1.132 ± 0.038
0.804HisGln: 0.804 ± 0.029
0.925HisArg: 0.925 ± 0.036
1.224HisSer: 1.224 ± 0.04
1.25HisThr: 1.25 ± 0.035
1.142HisVal: 1.142 ± 0.035
0.207HisTrp: 0.207 ± 0.014
0.788HisTyr: 0.788 ± 0.028
0.0HisXaa: 0.0 ± 0.0
Ile
6.186IleAla: 6.186 ± 0.094
0.787IleCys: 0.787 ± 0.03
3.823IleAsp: 3.823 ± 0.065
4.141IleGlu: 4.141 ± 0.066
2.562IlePhe: 2.562 ± 0.057
5.126IleGly: 5.126 ± 0.085
1.268IleHis: 1.268 ± 0.038
4.318IleIle: 4.318 ± 0.077
3.163IleLys: 3.163 ± 0.057
7.085IleLeu: 7.085 ± 0.105
1.454IleMet: 1.454 ± 0.04
2.351IleAsn: 2.351 ± 0.052
3.465IlePro: 3.465 ± 0.06
2.344IleGln: 2.344 ± 0.048
3.153IleArg: 3.153 ± 0.063
4.554IleSer: 4.554 ± 0.071
4.088IleThr: 4.088 ± 0.071
4.514IleVal: 4.514 ± 0.075
0.585IleTrp: 0.585 ± 0.024
1.893IleTyr: 1.893 ± 0.038
0.0IleXaa: 0.0 ± 0.0
Lys
5.27LysAla: 5.27 ± 0.071
0.34LysCys: 0.34 ± 0.019
3.083LysAsp: 3.083 ± 0.057
4.416LysGlu: 4.416 ± 0.079
1.471LysPhe: 1.471 ± 0.043
3.95LysGly: 3.95 ± 0.065
1.2LysHis: 1.2 ± 0.033
2.918LysIle: 2.918 ± 0.063
3.851LysLys: 3.851 ± 0.077
4.868LysLeu: 4.868 ± 0.083
1.322LysMet: 1.322 ± 0.042
2.27LysAsn: 2.27 ± 0.054
2.189LysPro: 2.189 ± 0.05
2.97LysGln: 2.97 ± 0.057
3.34LysArg: 3.34 ± 0.06
3.013LysSer: 3.013 ± 0.059
3.258LysThr: 3.258 ± 0.055
3.858LysVal: 3.858 ± 0.07
0.422LysTrp: 0.422 ± 0.024
1.461LysTyr: 1.461 ± 0.049
0.0LysXaa: 0.0 ± 0.0
Leu
9.306LeuAla: 9.306 ± 0.113
1.631LeuCys: 1.631 ± 0.039
5.799LeuAsp: 5.799 ± 0.072
6.181LeuGlu: 6.181 ± 0.086
5.578LeuPhe: 5.578 ± 0.1
7.706LeuGly: 7.706 ± 0.112
1.952LeuHis: 1.952 ± 0.048
6.515LeuIle: 6.515 ± 0.098
5.648LeuLys: 5.648 ± 0.089
12.488LeuLeu: 12.488 ± 0.162
2.809LeuMet: 2.809 ± 0.052
3.385LeuAsn: 3.385 ± 0.056
4.391LeuPro: 4.391 ± 0.068
4.093LeuGln: 4.093 ± 0.076
4.357LeuArg: 4.357 ± 0.064
9.04LeuSer: 9.04 ± 0.104
5.629LeuThr: 5.629 ± 0.078
8.069LeuVal: 8.069 ± 0.091
0.966LeuTrp: 0.966 ± 0.034
3.768LeuTyr: 3.768 ± 0.056
0.0LeuXaa: 0.0 ± 0.0
Met
2.372MetAla: 2.372 ± 0.048
0.224MetCys: 0.224 ± 0.016
1.434MetAsp: 1.434 ± 0.036
1.67MetGlu: 1.67 ± 0.04
1.002MetPhe: 1.002 ± 0.035
2.015MetGly: 2.015 ± 0.042
0.661MetHis: 0.661 ± 0.028
1.694MetIle: 1.694 ± 0.043
1.834MetLys: 1.834 ± 0.039
2.95MetLeu: 2.95 ± 0.058
0.726MetMet: 0.726 ± 0.028
1.167MetAsn: 1.167 ± 0.034
0.974MetPro: 0.974 ± 0.036
1.408MetGln: 1.408 ± 0.038
1.353MetArg: 1.353 ± 0.037
1.578MetSer: 1.578 ± 0.043
1.33MetThr: 1.33 ± 0.035
2.13MetVal: 2.13 ± 0.043
0.206MetTrp: 0.206 ± 0.013
0.774MetTyr: 0.774 ± 0.025
0.0MetXaa: 0.0 ± 0.0
Asn
2.897AsnAla: 2.897 ± 0.056
0.394AsnCys: 0.394 ± 0.023
1.664AsnAsp: 1.664 ± 0.04
2.117AsnGlu: 2.117 ± 0.047
1.44AsnPhe: 1.44 ± 0.042
2.522AsnGly: 2.522 ± 0.061
0.777AsnHis: 0.777 ± 0.029
2.417AsnIle: 2.417 ± 0.054
1.911AsnLys: 1.911 ± 0.044
4.389AsnLeu: 4.389 ± 0.069
0.887AsnMet: 0.887 ± 0.03
1.397AsnAsn: 1.397 ± 0.038
2.147AsnPro: 2.147 ± 0.048
1.513AsnGln: 1.513 ± 0.047
1.951AsnArg: 1.951 ± 0.046
2.221AsnSer: 2.221 ± 0.054
2.275AsnThr: 2.275 ± 0.059
2.084AsnVal: 2.084 ± 0.05
0.43AsnTrp: 0.43 ± 0.02
1.275AsnTyr: 1.275 ± 0.042
0.0AsnXaa: 0.0 ± 0.0
Pro
2.68ProAla: 2.68 ± 0.06
0.423ProCys: 0.423 ± 0.017
1.911ProAsp: 1.911 ± 0.046
2.316ProGlu: 2.316 ± 0.049
2.028ProPhe: 2.028 ± 0.048
2.194ProGly: 2.194 ± 0.044
0.678ProHis: 0.678 ± 0.023
2.662ProIle: 2.662 ± 0.051
1.949ProLys: 1.949 ± 0.051
4.248ProLeu: 4.248 ± 0.07
1.029ProMet: 1.029 ± 0.03
1.447ProAsn: 1.447 ± 0.039
1.172ProPro: 1.172 ± 0.04
1.361ProGln: 1.361 ± 0.035
1.234ProArg: 1.234 ± 0.035
3.15ProSer: 3.15 ± 0.066
2.208ProThr: 2.208 ± 0.052
3.059ProVal: 3.059 ± 0.063
0.414ProTrp: 0.414 ± 0.019
1.647ProTyr: 1.647 ± 0.039
0.0ProXaa: 0.0 ± 0.0
Gln
3.62GlnAla: 3.62 ± 0.064
0.357GlnCys: 0.357 ± 0.019
1.769GlnAsp: 1.769 ± 0.041
2.627GlnGlu: 2.627 ± 0.059
1.562GlnPhe: 1.562 ± 0.037
2.718GlnGly: 2.718 ± 0.064
0.692GlnHis: 0.692 ± 0.025
2.563GlnIle: 2.563 ± 0.056
2.733GlnLys: 2.733 ± 0.057
3.791GlnLeu: 3.791 ± 0.065
1.173GlnMet: 1.173 ± 0.03
1.559GlnAsn: 1.559 ± 0.052
1.039GlnPro: 1.039 ± 0.031
1.995GlnGln: 1.995 ± 0.058
1.868GlnArg: 1.868 ± 0.048
2.492GlnSer: 2.492 ± 0.052
2.236GlnThr: 2.236 ± 0.048
2.839GlnVal: 2.839 ± 0.054
0.391GlnTrp: 0.391 ± 0.017
1.322GlnTyr: 1.322 ± 0.039
0.0GlnXaa: 0.0 ± 0.0
Arg
2.693ArgAla: 2.693 ± 0.052
0.539ArgCys: 0.539 ± 0.022
2.175ArgAsp: 2.175 ± 0.048
2.887ArgGlu: 2.887 ± 0.059
2.237ArgPhe: 2.237 ± 0.045
2.458ArgGly: 2.458 ± 0.055
0.884ArgHis: 0.884 ± 0.035
3.557ArgIle: 3.557 ± 0.059
3.056ArgLys: 3.056 ± 0.051
4.703ArgLeu: 4.703 ± 0.071
1.629ArgMet: 1.629 ± 0.039
1.976ArgAsn: 1.976 ± 0.044
1.501ArgPro: 1.501 ± 0.064
1.641ArgGln: 1.641 ± 0.043
2.208ArgArg: 2.208 ± 0.05
3.123ArgSer: 3.123 ± 0.059
2.672ArgThr: 2.672 ± 0.051
2.723ArgVal: 2.723 ± 0.053
0.583ArgTrp: 0.583 ± 0.025
2.002ArgTyr: 2.002 ± 0.047
0.0ArgXaa: 0.0 ± 0.0
Ser
4.967SerAla: 4.967 ± 0.073
0.902SerCys: 0.902 ± 0.036
3.449SerAsp: 3.449 ± 0.055
4.047SerGlu: 4.047 ± 0.062
3.821SerPhe: 3.821 ± 0.064
4.967SerGly: 4.967 ± 0.075
1.328SerHis: 1.328 ± 0.04
5.006SerIle: 5.006 ± 0.069
3.454SerLys: 3.454 ± 0.055
8.629SerLeu: 8.629 ± 0.11
2.017SerMet: 2.017 ± 0.046
2.414SerAsn: 2.414 ± 0.054
2.264SerPro: 2.264 ± 0.051
2.343SerGln: 2.343 ± 0.052
2.953SerArg: 2.953 ± 0.054
4.944SerSer: 4.944 ± 0.084
3.618SerThr: 3.618 ± 0.067
4.86SerVal: 4.86 ± 0.075
0.824SerTrp: 0.824 ± 0.031
2.963SerTyr: 2.963 ± 0.056
0.0SerXaa: 0.0 ± 0.0
Thr
4.296ThrAla: 4.296 ± 0.08
0.654ThrCys: 0.654 ± 0.028
2.738ThrAsp: 2.738 ± 0.052
3.084ThrGlu: 3.084 ± 0.061
2.836ThrPhe: 2.836 ± 0.057
3.94ThrGly: 3.94 ± 0.079
1.081ThrHis: 1.081 ± 0.031
4.39ThrIle: 4.39 ± 0.075
2.896ThrLys: 2.896 ± 0.05
6.894ThrLeu: 6.894 ± 0.098
1.514ThrMet: 1.514 ± 0.037
2.121ThrAsn: 2.121 ± 0.051
2.21ThrPro: 2.21 ± 0.056
1.86ThrGln: 1.86 ± 0.045
2.048ThrArg: 2.048 ± 0.051
3.71ThrSer: 3.71 ± 0.066
3.33ThrThr: 3.33 ± 0.074
4.127ThrVal: 4.127 ± 0.072
0.636ThrTrp: 0.636 ± 0.026
2.317ThrTyr: 2.317 ± 0.054
0.0ThrXaa: 0.0 ± 0.0
Val
5.422ValAla: 5.422 ± 0.079
0.977ValCys: 0.977 ± 0.031
3.582ValAsp: 3.582 ± 0.063
3.979ValGlu: 3.979 ± 0.082
3.314ValPhe: 3.314 ± 0.065
4.793ValGly: 4.793 ± 0.081
1.388ValHis: 1.388 ± 0.037
4.591ValIle: 4.591 ± 0.074
3.411ValLys: 3.411 ± 0.066
7.817ValLeu: 7.817 ± 0.097
1.87ValMet: 1.87 ± 0.044
2.44ValAsn: 2.44 ± 0.051
2.655ValPro: 2.655 ± 0.057
2.806ValGln: 2.806 ± 0.057
3.208ValArg: 3.208 ± 0.063
4.93ValSer: 4.93 ± 0.083
3.789ValThr: 3.789 ± 0.082
5.466ValVal: 5.466 ± 0.084
0.684ValTrp: 0.684 ± 0.029
2.276ValTyr: 2.276 ± 0.05
0.0ValXaa: 0.0 ± 0.0
Trp
0.771TrpAla: 0.771 ± 0.03
0.12TrpCys: 0.12 ± 0.01
0.581TrpAsp: 0.581 ± 0.029
0.616TrpGlu: 0.616 ± 0.023
0.49TrpPhe: 0.49 ± 0.025
0.746TrpGly: 0.746 ± 0.031
0.225TrpHis: 0.225 ± 0.016
0.637TrpIle: 0.637 ± 0.028
0.661TrpLys: 0.661 ± 0.028
0.872TrpLeu: 0.872 ± 0.03
0.363TrpMet: 0.363 ± 0.021
0.572TrpAsn: 0.572 ± 0.026
0.346TrpPro: 0.346 ± 0.018
0.433TrpGln: 0.433 ± 0.023
0.44TrpArg: 0.44 ± 0.02
0.596TrpSer: 0.596 ± 0.028
0.561TrpThr: 0.561 ± 0.026
0.706TrpVal: 0.706 ± 0.028
0.133TrpTrp: 0.133 ± 0.012
0.481TrpTyr: 0.481 ± 0.025
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.068TyrAla: 3.068 ± 0.054
0.523TyrCys: 0.523 ± 0.025
2.003TyrAsp: 2.003 ± 0.052
2.304TyrGlu: 2.304 ± 0.048
1.594TyrPhe: 1.594 ± 0.042
2.615TyrGly: 2.615 ± 0.054
0.804TyrHis: 0.804 ± 0.032
1.988TyrIle: 1.988 ± 0.046
1.544TyrLys: 1.544 ± 0.043
4.089TyrLeu: 4.089 ± 0.074
0.733TyrMet: 0.733 ± 0.024
1.233TyrAsn: 1.233 ± 0.031
1.626TyrPro: 1.626 ± 0.035
1.621TyrGln: 1.621 ± 0.041
1.978TyrArg: 1.978 ± 0.043
2.394TyrSer: 2.394 ± 0.047
2.296TyrThr: 2.296 ± 0.049
2.086TyrVal: 2.086 ± 0.051
0.398TyrTrp: 0.398 ± 0.022
1.395TyrTyr: 1.395 ± 0.04
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3007 proteins (1003326 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski