Amino acid dipepetide frequency for Stappia sp. ES.058

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	16.699AlaAla: 16.699 ± 0.179	1.256AlaCys: 1.256 ± 0.036	7.569AlaAsp: 7.569 ± 0.091	7.635AlaGlu: 7.635 ± 0.096	4.865AlaPhe: 4.865 ± 0.066	11.422AlaGly: 11.422 ± 0.112	2.402AlaHis: 2.402 ± 0.046	6.184AlaIle: 6.184 ± 0.067	3.447AlaLys: 3.447 ± 0.056	13.863AlaLeu: 13.863 ± 0.131	3.47AlaMet: 3.47 ± 0.058	2.903AlaAsn: 2.903 ± 0.059	5.722AlaPro: 5.722 ± 0.083	3.689AlaGln: 3.689 ± 0.06	10.057AlaArg: 10.057 ± 0.109	6.654AlaSer: 6.654 ± 0.089	6.169AlaThr: 6.169 ± 0.07	8.997AlaVal: 8.997 ± 0.096	1.459AlaTrp: 1.459 ± 0.041	2.507AlaTyr: 2.507 ± 0.045	0.0AlaXaa: 0.0 ± 0.0
Cys	1.09CysAla: 1.09 ± 0.031	0.112CysCys: 0.112 ± 0.01	0.607CysAsp: 0.607 ± 0.022	0.491CysGlu: 0.491 ± 0.018	0.358CysPhe: 0.358 ± 0.017	1.032CysGly: 1.032 ± 0.03	0.244CysHis: 0.244 ± 0.014	0.38CysIle: 0.38 ± 0.02	0.214CysLys: 0.214 ± 0.013	0.911CysLeu: 0.911 ± 0.028	0.155CysMet: 0.155 ± 0.011	0.208CysAsn: 0.208 ± 0.013	0.469CysPro: 0.469 ± 0.019	0.235CysGln: 0.235 ± 0.015	0.667CysArg: 0.667 ± 0.024	0.473CysSer: 0.473 ± 0.02	0.401CysThr: 0.401 ± 0.021	0.675CysVal: 0.675 ± 0.026	0.108CysTrp: 0.108 ± 0.009	0.201CysTyr: 0.201 ± 0.013	0.0CysXaa: 0.0 ± 0.0
Asp	8.001AspAla: 8.001 ± 0.087	0.546AspCys: 0.546 ± 0.023	3.575AspAsp: 3.575 ± 0.062	3.548AspGlu: 3.548 ± 0.054	2.184AspPhe: 2.184 ± 0.042	5.905AspGly: 5.905 ± 0.078	1.298AspHis: 1.298 ± 0.034	3.141AspIle: 3.141 ± 0.048	1.657AspLys: 1.657 ± 0.042	6.516AspLeu: 6.516 ± 0.075	1.531AspMet: 1.531 ± 0.031	1.275AspAsn: 1.275 ± 0.038	3.872AspPro: 3.872 ± 0.05	1.477AspGln: 1.477 ± 0.031	4.492AspArg: 4.492 ± 0.076	2.081AspSer: 2.081 ± 0.04	3.292AspThr: 3.292 ± 0.059	4.36AspVal: 4.36 ± 0.066	1.038AspTrp: 1.038 ± 0.03	1.47AspTyr: 1.47 ± 0.033	0.0AspXaa: 0.0 ± 0.0
Glu	7.925GluAla: 7.925 ± 0.097	0.341GluCys: 0.341 ± 0.017	3.196GluAsp: 3.196 ± 0.059	3.47GluGlu: 3.47 ± 0.069	1.696GluPhe: 1.696 ± 0.036	4.272GluGly: 4.272 ± 0.061	1.107GluHis: 1.107 ± 0.03	3.836GluIle: 3.836 ± 0.057	2.143GluLys: 2.143 ± 0.048	4.93GluLeu: 4.93 ± 0.062	1.617GluMet: 1.617 ± 0.035	1.651GluAsn: 1.651 ± 0.039	2.654GluPro: 2.654 ± 0.05	1.784GluGln: 1.784 ± 0.048	5.083GluArg: 5.083 ± 0.069	2.31GluSer: 2.31 ± 0.04	4.474GluThr: 4.474 ± 0.061	3.928GluVal: 3.928 ± 0.055	0.614GluTrp: 0.614 ± 0.022	0.86GluTyr: 0.86 ± 0.029	0.0GluXaa: 0.0 ± 0.0
Phe	4.811PheAla: 4.811 ± 0.068	0.423PheCys: 0.423 ± 0.019	2.722PheAsp: 2.722 ± 0.051	2.244PheGlu: 2.244 ± 0.048	1.521PhePhe: 1.521 ± 0.039	3.637PheGly: 3.637 ± 0.057	0.753PheHis: 0.753 ± 0.025	1.57PheIle: 1.57 ± 0.035	0.959PheLys: 0.959 ± 0.026	3.715PheLeu: 3.715 ± 0.056	0.762PheMet: 0.762 ± 0.025	0.994PheAsn: 0.994 ± 0.026	1.6PhePro: 1.6 ± 0.039	1.043PheGln: 1.043 ± 0.029	2.324PheArg: 2.324 ± 0.044	2.405PheSer: 2.405 ± 0.038	1.929PheThr: 1.929 ± 0.048	2.917PheVal: 2.917 ± 0.05	0.512PheTrp: 0.512 ± 0.023	0.875PheTyr: 0.875 ± 0.028	0.0PheXaa: 0.0 ± 0.0
Gly	9.892GlyAla: 9.892 ± 0.11	0.917GlyCys: 0.917 ± 0.029	4.972GlyAsp: 4.972 ± 0.063	5.104GlyGlu: 5.104 ± 0.073	3.773GlyPhe: 3.773 ± 0.057	7.694GlyGly: 7.694 ± 0.17	1.936GlyHis: 1.936 ± 0.043	4.5GlyIle: 4.5 ± 0.068	2.938GlyLys: 2.938 ± 0.052	9.215GlyLeu: 9.215 ± 0.093	2.283GlyMet: 2.283 ± 0.047	2.075GlyAsn: 2.075 ± 0.049	3.517GlyPro: 3.517 ± 0.055	2.573GlyGln: 2.573 ± 0.044	6.261GlyArg: 6.261 ± 0.083	4.639GlySer: 4.639 ± 0.076	4.834GlyThr: 4.834 ± 0.086	6.352GlyVal: 6.352 ± 0.077	1.276GlyTrp: 1.276 ± 0.033	2.275GlyTyr: 2.275 ± 0.045	0.0GlyXaa: 0.0 ± 0.0
His	2.478HisAla: 2.478 ± 0.055	0.245HisCys: 0.245 ± 0.014	1.292HisAsp: 1.292 ± 0.034	1.061HisGlu: 1.061 ± 0.03	0.845HisPhe: 0.845 ± 0.03	1.907HisGly: 1.907 ± 0.042	0.571HisHis: 0.571 ± 0.027	0.886HisIle: 0.886 ± 0.025	0.493HisLys: 0.493 ± 0.021	2.04HisLeu: 2.04 ± 0.043	0.475HisMet: 0.475 ± 0.018	0.407HisAsn: 0.407 ± 0.021	1.353HisPro: 1.353 ± 0.034	0.527HisGln: 0.527 ± 0.021	1.431HisArg: 1.431 ± 0.032	0.934HisSer: 0.934 ± 0.025	0.857HisThr: 0.857 ± 0.028	1.639HisVal: 1.639 ± 0.032	0.266HisTrp: 0.266 ± 0.015	0.487HisTyr: 0.487 ± 0.019	0.0HisXaa: 0.0 ± 0.0
Ile	7.444IleAla: 7.444 ± 0.082	0.544IleCys: 0.544 ± 0.019	3.596IleAsp: 3.596 ± 0.052	3.33IleGlu: 3.33 ± 0.054	1.623IlePhe: 1.623 ± 0.039	4.88IleGly: 4.88 ± 0.069	0.859IleHis: 0.859 ± 0.026	1.861IleIle: 1.861 ± 0.043	1.261IleLys: 1.261 ± 0.029	4.525IleLeu: 4.525 ± 0.072	0.925IleMet: 0.925 ± 0.027	1.256IleAsn: 1.256 ± 0.033	2.199IlePro: 2.199 ± 0.049	1.14IleGln: 1.14 ± 0.03	3.208IleArg: 3.208 ± 0.048	2.969IleSer: 2.969 ± 0.05	2.436IleThr: 2.436 ± 0.046	4.28IleVal: 4.28 ± 0.063	0.584IleTrp: 0.584 ± 0.021	1.063IleTyr: 1.063 ± 0.027	0.0IleXaa: 0.0 ± 0.0
Lys	3.826LysAla: 3.826 ± 0.067	0.147LysCys: 0.147 ± 0.01	1.631LysAsp: 1.631 ± 0.039	1.405LysGlu: 1.405 ± 0.035	0.732LysPhe: 0.732 ± 0.026	2.431LysGly: 2.431 ± 0.042	0.544LysHis: 0.544 ± 0.022	1.586LysIle: 1.586 ± 0.037	1.086LysLys: 1.086 ± 0.039	2.864LysLeu: 2.864 ± 0.049	0.699LysMet: 0.699 ± 0.025	0.781LysAsn: 0.781 ± 0.026	1.77LysPro: 1.77 ± 0.037	0.851LysGln: 0.851 ± 0.028	2.42LysArg: 2.42 ± 0.046	1.719LysSer: 1.719 ± 0.037	2.183LysThr: 2.183 ± 0.046	2.218LysVal: 2.218 ± 0.051	0.331LysTrp: 0.331 ± 0.017	0.517LysTyr: 0.517 ± 0.02	0.0LysXaa: 0.0 ± 0.0
Leu	14.001LeuAla: 14.001 ± 0.142	0.945LeuCys: 0.945 ± 0.026	6.284LeuAsp: 6.284 ± 0.076	5.805LeuGlu: 5.805 ± 0.066	3.749LeuPhe: 3.749 ± 0.052	8.14LeuGly: 8.14 ± 0.085	1.841LeuHis: 1.841 ± 0.041	4.741LeuIle: 4.741 ± 0.08	3.472LeuLys: 3.472 ± 0.057	9.106LeuLeu: 9.106 ± 0.117	2.34LeuMet: 2.34 ± 0.048	2.457LeuAsn: 2.457 ± 0.042	5.385LeuPro: 5.385 ± 0.07	2.57LeuGln: 2.57 ± 0.053	6.711LeuArg: 6.711 ± 0.084	6.908LeuSer: 6.908 ± 0.085	5.587LeuThr: 5.587 ± 0.073	7.825LeuVal: 7.825 ± 0.093	1.095LeuTrp: 1.095 ± 0.031	2.005LeuTyr: 2.005 ± 0.039	0.0LeuXaa: 0.0 ± 0.0
Met	2.952MetAla: 2.952 ± 0.051	0.166MetCys: 0.166 ± 0.012	1.244MetAsp: 1.244 ± 0.03	1.207MetGlu: 1.207 ± 0.031	0.655MetPhe: 0.655 ± 0.023	1.713MetGly: 1.713 ± 0.038	0.43MetHis: 0.43 ± 0.019	1.422MetIle: 1.422 ± 0.037	0.92MetLys: 0.92 ± 0.03	2.435MetLeu: 2.435 ± 0.058	0.674MetMet: 0.674 ± 0.025	0.724MetAsn: 0.724 ± 0.022	1.463MetPro: 1.463 ± 0.035	0.733MetGln: 0.733 ± 0.024	1.911MetArg: 1.911 ± 0.041	1.833MetSer: 1.833 ± 0.035	2.017MetThr: 2.017 ± 0.037	1.702MetVal: 1.702 ± 0.038	0.221MetTrp: 0.221 ± 0.013	0.305MetTyr: 0.305 ± 0.015	0.0MetXaa: 0.0 ± 0.0
Asn	3.174AsnAla: 3.174 ± 0.058	0.215AsnCys: 0.215 ± 0.013	1.363AsnAsp: 1.363 ± 0.033	1.206AsnGlu: 1.206 ± 0.033	0.838AsnPhe: 0.838 ± 0.028	2.348AsnGly: 2.348 ± 0.061	0.459AsnHis: 0.459 ± 0.018	1.235AsnIle: 1.235 ± 0.035	0.605AsnLys: 0.605 ± 0.024	2.351AsnLeu: 2.351 ± 0.045	0.607AsnMet: 0.607 ± 0.021	0.598AsnAsn: 0.598 ± 0.03	1.721AsnPro: 1.721 ± 0.037	0.633AsnGln: 0.633 ± 0.022	1.784AsnArg: 1.784 ± 0.039	1.083AsnSer: 1.083 ± 0.034	1.263AsnThr: 1.263 ± 0.037	1.863AsnVal: 1.863 ± 0.04	0.381AsnTrp: 0.381 ± 0.02	0.577AsnTyr: 0.577 ± 0.023	0.0AsnXaa: 0.0 ± 0.0
Pro	6.214ProAla: 6.214 ± 0.081	0.348ProCys: 0.348 ± 0.018	3.965ProAsp: 3.965 ± 0.065	3.644ProGlu: 3.644 ± 0.052	2.034ProPhe: 2.034 ± 0.039	4.674ProGly: 4.674 ± 0.061	1.123ProHis: 1.123 ± 0.03	2.032ProIle: 2.032 ± 0.044	1.508ProLys: 1.508 ± 0.036	4.705ProLeu: 4.705 ± 0.067	1.158ProMet: 1.158 ± 0.032	1.204ProAsn: 1.204 ± 0.035	2.449ProPro: 2.449 ± 0.046	1.566ProGln: 1.566 ± 0.034	3.046ProArg: 3.046 ± 0.058	2.639ProSer: 2.639 ± 0.045	2.326ProThr: 2.326 ± 0.043	4.501ProVal: 4.501 ± 0.059	0.617ProTrp: 0.617 ± 0.018	1.091ProTyr: 1.091 ± 0.027	0.0ProXaa: 0.0 ± 0.0
Gln	3.795GlnAla: 3.795 ± 0.064	0.188GlnCys: 0.188 ± 0.011	1.623GlnAsp: 1.623 ± 0.031	1.458GlnGlu: 1.458 ± 0.035	0.931GlnPhe: 0.931 ± 0.025	2.208GlnGly: 2.208 ± 0.043	0.525GlnHis: 0.525 ± 0.021	1.649GlnIle: 1.649 ± 0.036	0.891GlnLys: 0.891 ± 0.026	2.37GlnLeu: 2.37 ± 0.04	0.864GlnMet: 0.864 ± 0.023	0.785GlnAsn: 0.785 ± 0.028	1.445GlnPro: 1.445 ± 0.035	0.897GlnGln: 0.897 ± 0.031	2.139GlnArg: 2.139 ± 0.043	1.665GlnSer: 1.665 ± 0.041	1.737GlnThr: 1.737 ± 0.038	2.094GlnVal: 2.094 ± 0.04	0.31GlnTrp: 0.31 ± 0.016	0.484GlnTyr: 0.484 ± 0.018	0.0GlnXaa: 0.0 ± 0.0
Arg	8.524ArgAla: 8.524 ± 0.104	0.587ArgCys: 0.587 ± 0.025	4.701ArgAsp: 4.701 ± 0.071	4.3ArgGlu: 4.3 ± 0.058	3.084ArgPhe: 3.084 ± 0.051	4.929ArgGly: 4.929 ± 0.077	1.815ArgHis: 1.815 ± 0.039	4.22ArgIle: 4.22 ± 0.059	2.37ArgLys: 2.37 ± 0.051	8.312ArgLeu: 8.312 ± 0.093	1.927ArgMet: 1.927 ± 0.038	1.802ArgAsn: 1.802 ± 0.038	3.589ArgPro: 3.589 ± 0.059	2.34ArgGln: 2.34 ± 0.04	5.74ArgArg: 5.74 ± 0.082	3.681ArgSer: 3.681 ± 0.061	3.448ArgThr: 3.448 ± 0.05	5.058ArgVal: 5.058 ± 0.068	0.87ArgTrp: 0.87 ± 0.028	1.56ArgTyr: 1.56 ± 0.037	0.0ArgXaa: 0.0 ± 0.0
Ser	6.662SerAla: 6.662 ± 0.087	0.453SerCys: 0.453 ± 0.018	3.454SerAsp: 3.454 ± 0.05	3.009SerGlu: 3.009 ± 0.051	2.185SerPhe: 2.185 ± 0.045	5.955SerGly: 5.955 ± 0.091	1.095SerHis: 1.095 ± 0.031	2.604SerIle: 2.604 ± 0.042	1.478SerLys: 1.478 ± 0.035	5.48SerLeu: 5.48 ± 0.07	1.31SerMet: 1.31 ± 0.029	1.284SerAsn: 1.284 ± 0.035	2.746SerPro: 2.746 ± 0.047	1.545SerGln: 1.545 ± 0.039	3.787SerArg: 3.787 ± 0.06	2.94SerSer: 2.94 ± 0.06	2.58SerThr: 2.58 ± 0.051	4.252SerVal: 4.252 ± 0.055	0.693SerTrp: 0.693 ± 0.023	1.21SerTyr: 1.21 ± 0.029	0.0SerXaa: 0.0 ± 0.0
Thr	6.457ThrAla: 6.457 ± 0.072	0.489ThrCys: 0.489 ± 0.022	3.006ThrAsp: 3.006 ± 0.05	2.582ThrGlu: 2.582 ± 0.048	2.082ThrPhe: 2.082 ± 0.047	5.483ThrGly: 5.483 ± 0.091	1.058ThrHis: 1.058 ± 0.027	2.793ThrIle: 2.793 ± 0.051	1.267ThrLys: 1.267 ± 0.034	6.127ThrLeu: 6.127 ± 0.081	1.215ThrMet: 1.215 ± 0.031	1.205ThrAsn: 1.205 ± 0.04	3.396ThrPro: 3.396 ± 0.042	1.458ThrGln: 1.458 ± 0.031	3.828ThrArg: 3.828 ± 0.059	2.944ThrSer: 2.944 ± 0.05	2.844ThrThr: 2.844 ± 0.058	4.584ThrVal: 4.584 ± 0.066	0.649ThrTrp: 0.649 ± 0.026	1.208ThrTyr: 1.208 ± 0.031	0.0ThrXaa: 0.0 ± 0.0
Val	9.524ValAla: 9.524 ± 0.096	0.734ValCys: 0.734 ± 0.022	4.449ValAsp: 4.449 ± 0.06	4.696ValGlu: 4.696 ± 0.072	3.209ValPhe: 3.209 ± 0.054	5.609ValGly: 5.609 ± 0.072	1.396ValHis: 1.396 ± 0.033	3.852ValIle: 3.852 ± 0.061	2.022ValLys: 2.022 ± 0.044	7.739ValLeu: 7.739 ± 0.082	1.933ValMet: 1.933 ± 0.042	1.864ValAsn: 1.864 ± 0.04	3.779ValPro: 3.779 ± 0.062	1.86ValGln: 1.86 ± 0.036	5.052ValArg: 5.052 ± 0.061	4.872ValSer: 4.872 ± 0.064	4.457ValThr: 4.457 ± 0.059	6.033ValVal: 6.033 ± 0.073	0.94ValTrp: 0.94 ± 0.027	1.503ValTyr: 1.503 ± 0.036	0.0ValXaa: 0.0 ± 0.0
Trp	1.168TrpAla: 1.168 ± 0.034	0.122TrpCys: 0.122 ± 0.009	0.623TrpAsp: 0.623 ± 0.023	0.515TrpGlu: 0.515 ± 0.019	0.496TrpPhe: 0.496 ± 0.02	0.886TrpGly: 0.886 ± 0.025	0.289TrpHis: 0.289 ± 0.014	0.655TrpIle: 0.655 ± 0.024	0.398TrpLys: 0.398 ± 0.017	1.495TrpLeu: 1.495 ± 0.038	0.357TrpMet: 0.357 ± 0.017	0.338TrpAsn: 0.338 ± 0.018	0.68TrpPro: 0.68 ± 0.023	0.487TrpGln: 0.487 ± 0.018	1.147TrpArg: 1.147 ± 0.039	0.825TrpSer: 0.825 ± 0.023	0.759TrpThr: 0.759 ± 0.024	0.763TrpVal: 0.763 ± 0.026	0.219TrpTrp: 0.219 ± 0.013	0.28TrpTyr: 0.28 ± 0.015	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.334TyrAla: 2.334 ± 0.045	0.255TyrCys: 0.255 ± 0.014	1.384TyrAsp: 1.384 ± 0.034	1.183TyrGlu: 1.183 ± 0.029	0.857TyrPhe: 0.857 ± 0.03	1.901TyrGly: 1.901 ± 0.04	0.451TyrHis: 0.451 ± 0.017	0.835TyrIle: 0.835 ± 0.023	0.611TyrLys: 0.611 ± 0.021	2.269TyrLeu: 2.269 ± 0.046	0.424TyrMet: 0.424 ± 0.017	0.492TyrAsn: 0.492 ± 0.02	1.035TyrPro: 1.035 ± 0.028	0.65TyrGln: 0.65 ± 0.032	1.769TyrArg: 1.769 ± 0.039	1.145TyrSer: 1.145 ± 0.035	1.081TyrThr: 1.081 ± 0.032	1.482TyrVal: 1.482 ± 0.037	0.32TyrTrp: 0.32 ± 0.018	0.534TyrTyr: 0.534 ± 0.023	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4219 proteins (1348451 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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