Amino acid dipepetide frequency for Rubella virus (RUBV)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
20.138AlaAla: 20.138 ± 3.218
5.035AlaCys: 5.035 ± 0.83
5.664AlaAsp: 5.664 ± 1.518
5.664AlaGlu: 5.664 ± 1.518
4.405AlaPhe: 4.405 ± 0.342
12.272AlaGly: 12.272 ± 2.032
4.091AlaHis: 4.091 ± 0.329
3.147AlaIle: 3.147 ± 1.179
1.573AlaLys: 1.573 ± 0.338
16.048AlaLeu: 16.048 ± 2.541
1.573AlaMet: 1.573 ± 0.338
2.832AlaAsn: 2.832 ± 0.508
11.328AlaPro: 11.328 ± 2.497
5.349AlaGln: 5.349 ± 0.847
9.755AlaArg: 9.755 ± 1.692
5.979AlaSer: 5.979 ± 0.829
7.867AlaThr: 7.867 ± 0.18
7.867AlaVal: 7.867 ± 0.18
2.832AlaTrp: 2.832 ± 1.011
4.405AlaTyr: 4.405 ± 0.845
0.0AlaXaa: 0.0 ± 0.0
Cys
6.923CysAla: 6.923 ± 1.185
0.315CysCys: 0.315 ± 0.335
0.629CysAsp: 0.629 ± 0.336
2.203CysGlu: 2.203 ± 0.332
0.315CysPhe: 0.315 ± 0.335
5.349CysGly: 5.349 ± 1.165
1.888CysHis: 1.888 ± 1.003
0.629CysIle: 0.629 ± 0.167
0.629CysLys: 0.629 ± 0.336
0.944CysLeu: 0.944 ± 0.002
0.315CysMet: 0.315 ± 0.168
0.944CysAsn: 0.944 ± 0.502
2.517CysPro: 2.517 ± 0.842
0.629CysGln: 0.629 ± 0.167
3.461CysArg: 3.461 ± 0.341
0.944CysSer: 0.944 ± 0.502
2.517CysThr: 2.517 ± 0.339
1.573CysVal: 1.573 ± 0.165
0.944CysTrp: 0.944 ± 0.002
0.629CysTyr: 0.629 ± 0.67
0.0CysXaa: 0.0 ± 0.0
Asp
5.979AspAla: 5.979 ± 2.189
1.888AspCys: 1.888 ± 0.506
2.517AspAsp: 2.517 ± 0.339
1.888AspGlu: 1.888 ± 0.506
1.573AspPhe: 1.573 ± 0.165
5.035AspGly: 5.035 ± 0.176
1.888AspHis: 1.888 ± 0.506
1.573AspIle: 1.573 ± 0.841
0.0AspLys: 0.0 ± 0.0
4.405AspLeu: 4.405 ± 0.342
1.259AspMet: 1.259 ± 0.277
0.0AspAsn: 0.0 ± 0.0
5.979AspPro: 5.979 ± 0.177
0.315AspGln: 0.315 ± 0.168
4.72AspArg: 4.72 ± 1.517
1.888AspSer: 1.888 ± 1.506
2.832AspThr: 2.832 ± 0.005
3.776AspVal: 3.776 ± 0.006
1.259AspTrp: 1.259 ± 0.836
1.259AspTyr: 1.259 ± 0.673
0.0AspXaa: 0.0 ± 0.0
Glu
5.664GluAla: 5.664 ± 0.512
0.315GluCys: 0.315 ± 0.168
4.091GluAsp: 4.091 ± 0.174
2.517GluGlu: 2.517 ± 0.339
0.315GluPhe: 0.315 ± 0.168
4.091GluGly: 4.091 ± 0.174
1.259GluHis: 1.259 ± 0.333
2.203GluIle: 2.203 ± 0.674
0.315GluLys: 0.315 ± 0.168
5.035GluLeu: 5.035 ± 0.679
0.629GluMet: 0.629 ± 0.167
0.0GluAsn: 0.0 ± 0.0
3.147GluPro: 3.147 ± 0.676
1.259GluGln: 1.259 ± 0.17
6.608GluArg: 6.608 ± 1.52
1.573GluSer: 1.573 ± 0.668
2.203GluThr: 2.203 ± 0.332
6.293GluVal: 6.293 ± 1.855
2.203GluTrp: 2.203 ± 0.171
0.629GluTyr: 0.629 ± 0.167
0.0GluXaa: 0.0 ± 0.0
Phe
2.517PheAla: 2.517 ± 0.339
0.944PheCys: 0.944 ± 0.002
1.259PheAsp: 1.259 ± 0.673
0.629PheGlu: 0.629 ± 0.167
0.629PhePhe: 0.629 ± 0.336
1.888PheGly: 1.888 ± 0.5
0.944PheHis: 0.944 ± 0.002
0.0PheIle: 0.0 ± 0.0
0.944PheLys: 0.944 ± 0.002
2.203PheLeu: 2.203 ± 0.332
0.315PheMet: 0.315 ± 0.335
0.315PheAsn: 0.315 ± 0.335
1.259PhePro: 1.259 ± 0.333
0.944PheGln: 0.944 ± 0.002
1.573PheArg: 1.573 ± 0.338
0.629PheSer: 0.629 ± 0.336
2.517PheThr: 2.517 ± 0.667
1.259PheVal: 1.259 ± 0.17
0.629PheTrp: 0.629 ± 0.67
0.629PheTyr: 0.629 ± 0.167
0.0PheXaa: 0.0 ± 0.0
Gly
8.811GlyAla: 8.811 ± 0.321
4.405GlyCys: 4.405 ± 0.664
4.405GlyAsp: 4.405 ± 0.342
5.035GlyGlu: 5.035 ± 0.327
0.944GlyPhe: 0.944 ± 0.502
7.552GlyGly: 7.552 ± 2.0
3.776GlyHis: 3.776 ± 1.0
2.203GlyIle: 2.203 ± 1.177
1.259GlyLys: 1.259 ± 0.333
7.867GlyLeu: 7.867 ± 2.335
1.259GlyMet: 1.259 ± 0.673
1.573GlyAsn: 1.573 ± 0.668
8.181GlyPro: 8.181 ± 0.348
1.888GlyGln: 1.888 ± 1.003
5.035GlyArg: 5.035 ± 0.327
4.405GlySer: 4.405 ± 0.342
5.664GlyThr: 5.664 ± 1.5
4.091GlyVal: 4.091 ± 0.832
1.888GlyTrp: 1.888 ± 0.003
1.259GlyTyr: 1.259 ± 0.333
0.0GlyXaa: 0.0 ± 0.0
His
3.776HisAla: 3.776 ± 0.006
0.629HisCys: 0.629 ± 0.336
2.203HisAsp: 2.203 ± 0.332
1.573HisGlu: 1.573 ± 0.841
1.573HisPhe: 1.573 ± 0.338
2.203HisGly: 2.203 ± 1.338
1.573HisHis: 1.573 ± 1.171
1.259HisIle: 1.259 ± 0.17
0.315HisLys: 0.315 ± 0.335
3.461HisLeu: 3.461 ± 1.347
0.629HisMet: 0.629 ± 0.167
0.315HisAsn: 0.315 ± 0.168
4.405HisPro: 4.405 ± 0.664
1.259HisGln: 1.259 ± 0.333
1.259HisArg: 1.259 ± 0.333
0.944HisSer: 0.944 ± 0.502
2.517HisThr: 2.517 ± 1.17
2.832HisVal: 2.832 ± 0.508
0.944HisTrp: 0.944 ± 0.502
1.573HisTyr: 1.573 ± 0.338
0.0HisXaa: 0.0 ± 0.0
Ile
1.259IleAla: 1.259 ± 0.17
1.573IleCys: 1.573 ± 0.668
2.203IleAsp: 2.203 ± 0.674
1.259IleGlu: 1.259 ± 0.17
1.573IlePhe: 1.573 ± 0.338
0.629IleGly: 0.629 ± 0.167
0.944IleHis: 0.944 ± 0.002
0.629IleIle: 0.629 ± 0.336
0.944IleLys: 0.944 ± 0.505
0.315IleLeu: 0.315 ± 0.168
1.259IleMet: 1.259 ± 0.17
0.0IleAsn: 0.0 ± 0.0
2.203IlePro: 2.203 ± 0.674
0.944IleGln: 0.944 ± 0.505
1.888IleArg: 1.888 ± 0.003
0.944IleSer: 0.944 ± 0.505
0.629IleThr: 0.629 ± 0.167
2.517IleVal: 2.517 ± 0.842
0.629IleTrp: 0.629 ± 0.167
0.944IleTyr: 0.944 ± 0.505
0.0IleXaa: 0.0 ± 0.0
Lys
1.259LysAla: 1.259 ± 0.17
1.259LysCys: 1.259 ± 0.333
0.0LysAsp: 0.0 ± 0.0
0.944LysGlu: 0.944 ± 0.505
1.573LysPhe: 1.573 ± 0.668
1.573LysGly: 1.573 ± 0.338
0.629LysHis: 0.629 ± 0.167
0.629LysIle: 0.629 ± 0.167
0.0LysLys: 0.0 ± 0.0
0.944LysLeu: 0.944 ± 0.505
0.0LysMet: 0.0 ± 0.0
0.944LysAsn: 0.944 ± 0.505
0.944LysPro: 0.944 ± 0.002
0.315LysGln: 0.315 ± 0.335
0.944LysArg: 0.944 ± 0.505
0.315LysSer: 0.315 ± 0.168
1.259LysThr: 1.259 ± 0.333
0.629LysVal: 0.629 ± 0.336
0.315LysTrp: 0.315 ± 0.168
0.0LysTyr: 0.0 ± 0.0
0.0LysXaa: 0.0 ± 0.0
Leu
13.531LeuAla: 13.531 ± 1.195
2.517LeuCys: 2.517 ± 0.339
4.72LeuAsp: 4.72 ± 1.014
5.035LeuGlu: 5.035 ± 1.182
0.944LeuPhe: 0.944 ± 0.505
5.035LeuGly: 5.035 ± 0.83
4.405LeuHis: 4.405 ± 0.845
1.573LeuIle: 1.573 ± 0.165
1.888LeuLys: 1.888 ± 0.506
7.237LeuLeu: 7.237 ± 0.659
0.944LeuMet: 0.944 ± 0.002
1.573LeuAsn: 1.573 ± 0.165
4.72LeuPro: 4.72 ± 0.008
2.203LeuGln: 2.203 ± 0.835
8.181LeuArg: 8.181 ± 0.348
5.349LeuSer: 5.349 ± 0.344
4.091LeuThr: 4.091 ± 0.174
4.405LeuVal: 4.405 ± 1.167
2.203LeuTrp: 2.203 ± 0.171
1.888LeuTyr: 1.888 ± 0.506
0.0LeuXaa: 0.0 ± 0.0
Met
1.573MetAla: 1.573 ± 0.165
1.573MetCys: 1.573 ± 0.841
0.629MetAsp: 0.629 ± 0.167
1.259MetGlu: 1.259 ± 0.17
0.0MetPhe: 0.0 ± 0.0
0.629MetGly: 0.629 ± 0.167
0.629MetHis: 0.629 ± 0.336
0.0MetIle: 0.0 ± 0.0
0.315MetLys: 0.315 ± 0.168
0.315MetLeu: 0.315 ± 0.168
0.0MetMet: 0.0 ± 0.0
0.629MetAsn: 0.629 ± 0.167
1.259MetPro: 1.259 ± 0.333
0.944MetGln: 0.944 ± 0.002
2.203MetArg: 2.203 ± 0.171
0.944MetSer: 0.944 ± 0.002
0.315MetThr: 0.315 ± 0.168
0.944MetVal: 0.944 ± 0.002
0.315MetTrp: 0.315 ± 0.168
0.315MetTyr: 0.315 ± 0.335
0.0MetXaa: 0.0 ± 0.0
Asn
4.091AsnAla: 4.091 ± 0.677
0.944AsnCys: 0.944 ± 0.502
0.629AsnAsp: 0.629 ± 0.167
0.315AsnGlu: 0.315 ± 0.168
0.0AsnPhe: 0.0 ± 0.0
0.944AsnGly: 0.944 ± 0.502
0.629AsnHis: 0.629 ± 0.336
0.315AsnIle: 0.315 ± 0.168
0.315AsnLys: 0.315 ± 0.168
1.888AsnLeu: 1.888 ± 0.003
0.315AsnMet: 0.315 ± 0.168
0.315AsnAsn: 0.315 ± 0.168
1.259AsnPro: 1.259 ± 0.836
0.944AsnGln: 0.944 ± 0.502
0.629AsnArg: 0.629 ± 0.167
0.0AsnSer: 0.0 ± 0.0
1.573AsnThr: 1.573 ± 0.668
1.259AsnVal: 1.259 ± 0.333
0.0AsnTrp: 0.0 ± 0.0
0.315AsnTyr: 0.315 ± 0.335
0.0AsnXaa: 0.0 ± 0.0
Pro
12.272ProAla: 12.272 ± 0.02
2.203ProCys: 2.203 ± 0.332
4.405ProAsp: 4.405 ± 0.342
6.293ProGlu: 6.293 ± 0.158
2.203ProPhe: 2.203 ± 0.835
7.237ProGly: 7.237 ± 1.162
2.203ProHis: 2.203 ± 0.332
0.629ProIle: 0.629 ± 0.167
1.573ProLys: 1.573 ± 0.338
5.979ProLeu: 5.979 ± 0.68
0.944ProMet: 0.944 ± 0.502
0.944ProAsn: 0.944 ± 0.002
18.565ProPro: 18.565 ± 2.653
2.203ProGln: 2.203 ± 0.835
9.755ProArg: 9.755 ± 0.32
2.832ProSer: 2.832 ± 1.011
6.608ProThr: 6.608 ± 1.499
3.776ProVal: 3.776 ± 1.0
2.832ProTrp: 2.832 ± 1.002
1.888ProTyr: 1.888 ± 0.003
0.0ProXaa: 0.0 ± 0.0
Gln
4.091GlnAla: 4.091 ± 0.174
0.629GlnCys: 0.629 ± 0.167
0.944GlnAsp: 0.944 ± 0.002
0.944GlnGlu: 0.944 ± 0.002
0.315GlnPhe: 0.315 ± 0.168
2.832GlnGly: 2.832 ± 0.005
1.573GlnHis: 1.573 ± 0.668
0.315GlnIle: 0.315 ± 0.168
0.944GlnLys: 0.944 ± 0.002
1.888GlnLeu: 1.888 ± 1.506
0.944GlnMet: 0.944 ± 0.505
0.0GlnAsn: 0.0 ± 0.0
2.517GlnPro: 2.517 ± 1.17
1.573GlnGln: 1.573 ± 0.668
3.147GlnArg: 3.147 ± 0.33
2.203GlnSer: 2.203 ± 0.835
1.888GlnThr: 1.888 ± 0.5
2.517GlnVal: 2.517 ± 0.339
0.0GlnTrp: 0.0 ± 0.0
0.629GlnTyr: 0.629 ± 0.67
0.0GlnXaa: 0.0 ± 0.0
Arg
15.419ArgAla: 15.419 ± 1.198
3.147ArgCys: 3.147 ± 0.676
5.349ArgAsp: 5.349 ± 1.35
3.461ArgGlu: 3.461 ± 1.85
1.888ArgPhe: 1.888 ± 0.5
8.181ArgGly: 8.181 ± 0.658
3.461ArgHis: 3.461 ± 0.341
2.832ArgIle: 2.832 ± 0.005
0.944ArgLys: 0.944 ± 0.002
5.349ArgLeu: 5.349 ± 0.662
2.203ArgMet: 2.203 ± 0.198
0.629ArgAsn: 0.629 ± 0.67
7.237ArgPro: 7.237 ± 0.156
1.888ArgGln: 1.888 ± 0.5
7.867ArgArg: 7.867 ± 0.18
3.147ArgSer: 3.147 ± 0.676
4.405ArgThr: 4.405 ± 0.845
7.552ArgVal: 7.552 ± 1.018
3.461ArgTrp: 3.461 ± 0.162
2.203ArgTyr: 2.203 ± 1.177
0.0ArgXaa: 0.0 ± 0.0
Ser
5.979SerAla: 5.979 ± 0.68
1.573SerCys: 1.573 ± 0.668
3.147SerAsp: 3.147 ± 0.833
1.888SerGlu: 1.888 ± 0.003
0.629SerPhe: 0.629 ± 0.167
2.832SerGly: 2.832 ± 1.002
0.629SerHis: 0.629 ± 0.336
0.944SerIle: 0.944 ± 0.505
0.315SerLys: 0.315 ± 0.335
3.147SerLeu: 3.147 ± 1.179
0.0SerMet: 0.0 ± 0.0
0.629SerAsn: 0.629 ± 0.336
4.72SerPro: 4.72 ± 0.008
1.888SerGln: 1.888 ± 0.5
4.091SerArg: 4.091 ± 1.335
0.944SerSer: 0.944 ± 0.502
2.517SerThr: 2.517 ± 0.164
3.147SerVal: 3.147 ± 0.676
1.259SerTrp: 1.259 ± 0.17
1.888SerTyr: 1.888 ± 0.5
0.0SerXaa: 0.0 ± 0.0
Thr
8.496ThrAla: 8.496 ± 1.496
1.573ThrCys: 1.573 ± 0.165
2.203ThrAsp: 2.203 ± 0.171
4.72ThrGlu: 4.72 ± 0.008
0.629ThrPhe: 0.629 ± 0.167
3.461ThrGly: 3.461 ± 0.665
1.573ThrHis: 1.573 ± 0.165
0.944ThrIle: 0.944 ± 0.505
0.944ThrLys: 0.944 ± 0.002
5.035ThrLeu: 5.035 ± 1.685
0.315ThrMet: 0.315 ± 0.335
1.573ThrAsn: 1.573 ± 0.165
8.181ThrPro: 8.181 ± 2.67
1.259ThrGln: 1.259 ± 0.333
6.608ThrArg: 6.608 ± 0.011
2.832ThrSer: 2.832 ± 0.005
4.405ThrThr: 4.405 ± 2.173
4.72ThrVal: 4.72 ± 0.999
0.944ThrTrp: 0.944 ± 0.002
1.259ThrTyr: 1.259 ± 0.333
0.0ThrXaa: 0.0 ± 0.0
Val
9.44ValAla: 9.44 ± 3.537
2.517ValCys: 2.517 ± 0.164
2.517ValAsp: 2.517 ± 0.164
3.147ValGlu: 3.147 ± 0.833
1.888ValPhe: 1.888 ± 0.003
5.349ValGly: 5.349 ± 0.344
1.259ValHis: 1.259 ± 0.673
1.888ValIle: 1.888 ± 0.5
0.629ValLys: 0.629 ± 0.167
6.293ValLeu: 6.293 ± 0.158
1.259ValMet: 1.259 ± 0.17
1.259ValAsn: 1.259 ± 0.333
5.349ValPro: 5.349 ± 0.159
1.573ValGln: 1.573 ± 0.165
9.125ValArg: 9.125 ± 0.853
3.776ValSer: 3.776 ± 0.006
3.147ValThr: 3.147 ± 0.833
4.405ValVal: 4.405 ± 0.664
1.573ValTrp: 1.573 ± 0.668
1.259ValTyr: 1.259 ± 0.17
0.0ValXaa: 0.0 ± 0.0
Trp
3.776TrpAla: 3.776 ± 0.006
0.315TrpCys: 0.315 ± 0.335
1.888TrpAsp: 1.888 ± 0.003
1.259TrpGlu: 1.259 ± 0.17
0.315TrpPhe: 0.315 ± 0.168
2.203TrpGly: 2.203 ± 1.338
1.573TrpHis: 1.573 ± 0.668
0.944TrpIle: 0.944 ± 0.002
0.315TrpLys: 0.315 ± 0.168
2.832TrpLeu: 2.832 ± 0.005
0.0TrpMet: 0.0 ± 0.0
0.629TrpAsn: 0.629 ± 0.167
0.629TrpPro: 0.629 ± 0.336
1.573TrpGln: 1.573 ± 0.165
1.573TrpArg: 1.573 ± 0.338
1.259TrpSer: 1.259 ± 0.333
0.944TrpThr: 0.944 ± 0.002
2.203TrpVal: 2.203 ± 0.332
0.629TrpTrp: 0.629 ± 0.167
0.0TrpTyr: 0.0 ± 0.0
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.832TyrAla: 2.832 ± 0.508
0.944TyrCys: 0.944 ± 0.505
0.944TyrAsp: 0.944 ± 0.505
0.315TyrGlu: 0.315 ± 0.168
0.315TyrPhe: 0.315 ± 0.335
2.203TyrGly: 2.203 ± 0.835
0.315TyrHis: 0.315 ± 0.335
0.629TyrIle: 0.629 ± 0.167
0.315TyrLys: 0.315 ± 0.335
1.259TyrLeu: 1.259 ± 0.333
0.315TyrMet: 0.315 ± 0.168
1.573TyrAsn: 1.573 ± 0.668
0.944TyrPro: 0.944 ± 0.002
0.944TyrGln: 0.944 ± 0.502
2.203TyrArg: 2.203 ± 0.674
1.259TyrSer: 1.259 ± 0.17
3.776TyrThr: 3.776 ± 1.012
1.888TyrVal: 1.888 ± 0.506
0.0TyrTrp: 0.0 ± 0.0
1.888TyrTyr: 1.888 ± 0.003
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2 proteins (3179 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski