Amino acid dipepetide frequency for Mesorhizobium sp. B2-3-3

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	19.092AlaAla: 19.092 ± 0.119	1.0AlaCys: 1.0 ± 0.017	7.72AlaAsp: 7.72 ± 0.049	8.079AlaGlu: 8.079 ± 0.062	4.04AlaPhe: 4.04 ± 0.034	12.367AlaGly: 12.367 ± 0.08	2.523AlaHis: 2.523 ± 0.03	4.793AlaIle: 4.793 ± 0.041	3.63AlaLys: 3.63 ± 0.041	13.681AlaLeu: 13.681 ± 0.082	3.014AlaMet: 3.014 ± 0.031	2.433AlaAsn: 2.433 ± 0.033	6.278AlaPro: 6.278 ± 0.057	3.575AlaGln: 3.575 ± 0.035	9.281AlaArg: 9.281 ± 0.057	6.445AlaSer: 6.445 ± 0.043	6.533AlaThr: 6.533 ± 0.049	10.919AlaVal: 10.919 ± 0.072	1.656AlaTrp: 1.656 ± 0.025	2.719AlaTyr: 2.719 ± 0.028	0.0AlaXaa: 0.0 ± 0.0
Cys	0.997CysAla: 0.997 ± 0.019	0.097CysCys: 0.097 ± 0.005	0.47CysAsp: 0.47 ± 0.011	0.402CysGlu: 0.402 ± 0.01	0.273CysPhe: 0.273 ± 0.009	0.937CysGly: 0.937 ± 0.014	0.208CysHis: 0.208 ± 0.008	0.252CysIle: 0.252 ± 0.009	0.147CysLys: 0.147 ± 0.006	0.722CysLeu: 0.722 ± 0.014	0.136CysMet: 0.136 ± 0.005	0.168CysAsn: 0.168 ± 0.007	0.434CysPro: 0.434 ± 0.011	0.178CysGln: 0.178 ± 0.007	0.593CysArg: 0.593 ± 0.013	0.449CysSer: 0.449 ± 0.012	0.458CysThr: 0.458 ± 0.012	0.62CysVal: 0.62 ± 0.013	0.12CysTrp: 0.12 ± 0.006	0.169CysTyr: 0.169 ± 0.006	0.0CysXaa: 0.0 ± 0.0
Asp	7.328AspAla: 7.328 ± 0.049	0.443AspCys: 0.443 ± 0.01	3.367AspAsp: 3.367 ± 0.032	3.708AspGlu: 3.708 ± 0.034	2.014AspPhe: 2.014 ± 0.022	5.965AspGly: 5.965 ± 0.046	1.372AspHis: 1.372 ± 0.019	2.544AspIle: 2.544 ± 0.031	1.591AspLys: 1.591 ± 0.023	5.883AspLeu: 5.883 ± 0.041	1.113AspMet: 1.113 ± 0.018	1.181AspAsn: 1.181 ± 0.019	3.969AspPro: 3.969 ± 0.036	1.62AspGln: 1.62 ± 0.023	4.739AspArg: 4.739 ± 0.043	2.464AspSer: 2.464 ± 0.028	3.036AspThr: 3.036 ± 0.03	4.506AspVal: 4.506 ± 0.036	0.984AspTrp: 0.984 ± 0.017	1.285AspTyr: 1.285 ± 0.021	0.0AspXaa: 0.0 ± 0.0
Glu	7.476GluAla: 7.476 ± 0.055	0.362GluCys: 0.362 ± 0.011	2.832GluAsp: 2.832 ± 0.031	3.363GluGlu: 3.363 ± 0.036	1.595GluPhe: 1.595 ± 0.021	4.318GluGly: 4.318 ± 0.034	1.322GluHis: 1.322 ± 0.017	2.875GluIle: 2.875 ± 0.031	2.026GluLys: 2.026 ± 0.028	6.0GluLeu: 6.0 ± 0.046	1.182GluMet: 1.182 ± 0.018	1.309GluAsn: 1.309 ± 0.016	3.088GluPro: 3.088 ± 0.033	2.127GluGln: 2.127 ± 0.025	5.053GluArg: 5.053 ± 0.038	2.458GluSer: 2.458 ± 0.025	3.106GluThr: 3.106 ± 0.026	4.011GluVal: 4.011 ± 0.037	0.703GluTrp: 0.703 ± 0.014	1.025GluTyr: 1.025 ± 0.016	0.0GluXaa: 0.0 ± 0.0
Phe	4.161PheAla: 4.161 ± 0.032	0.33PheCys: 0.33 ± 0.01	2.311PheAsp: 2.311 ± 0.026	1.798PheGlu: 1.798 ± 0.022	1.182PhePhe: 1.182 ± 0.02	3.406PheGly: 3.406 ± 0.031	0.709PheHis: 0.709 ± 0.014	1.249PheIle: 1.249 ± 0.02	0.765PheLys: 0.765 ± 0.016	3.012PheLeu: 3.012 ± 0.031	0.616PheMet: 0.616 ± 0.012	0.799PheAsn: 0.799 ± 0.014	1.504PhePro: 1.504 ± 0.02	0.851PheGln: 0.851 ± 0.016	2.069PheArg: 2.069 ± 0.025	1.929PheSer: 1.929 ± 0.023	1.994PheThr: 1.994 ± 0.024	2.618PheVal: 2.618 ± 0.03	0.498PheTrp: 0.498 ± 0.011	0.73PheTyr: 0.73 ± 0.014	0.0PheXaa: 0.0 ± 0.0
Gly	10.358GlyAla: 10.358 ± 0.065	0.813GlyCys: 0.813 ± 0.017	4.984GlyAsp: 4.984 ± 0.043	4.971GlyGlu: 4.971 ± 0.035	3.293GlyPhe: 3.293 ± 0.032	8.296GlyGly: 8.296 ± 0.064	2.172GlyHis: 2.172 ± 0.024	4.147GlyIle: 4.147 ± 0.032	3.163GlyLys: 3.163 ± 0.037	9.276GlyLeu: 9.276 ± 0.063	2.178GlyMet: 2.178 ± 0.021	2.072GlyAsn: 2.072 ± 0.031	4.498GlyPro: 4.498 ± 0.039	2.724GlyGln: 2.724 ± 0.029	7.0GlyArg: 7.0 ± 0.048	5.36GlySer: 5.36 ± 0.041	5.782GlyThr: 5.782 ± 0.055	6.853GlyVal: 6.853 ± 0.044	1.53GlyTrp: 1.53 ± 0.022	2.293GlyTyr: 2.293 ± 0.022	0.0GlyXaa: 0.0 ± 0.0
His	2.485HisAla: 2.485 ± 0.027	0.202HisCys: 0.202 ± 0.008	1.299HisAsp: 1.299 ± 0.017	1.143HisGlu: 1.143 ± 0.018	0.772HisPhe: 0.772 ± 0.014	2.235HisGly: 2.235 ± 0.025	0.635HisHis: 0.635 ± 0.016	0.811HisIle: 0.811 ± 0.015	0.427HisLys: 0.427 ± 0.011	2.199HisLeu: 2.199 ± 0.027	0.431HisMet: 0.431 ± 0.01	0.409HisAsn: 0.409 ± 0.01	1.538HisPro: 1.538 ± 0.02	0.615HisGln: 0.615 ± 0.013	1.81HisArg: 1.81 ± 0.023	1.019HisSer: 1.019 ± 0.017	1.116HisThr: 1.116 ± 0.016	1.606HisVal: 1.606 ± 0.022	0.348HisTrp: 0.348 ± 0.009	0.518HisTyr: 0.518 ± 0.012	0.0HisXaa: 0.0 ± 0.0
Ile	5.94IleAla: 5.94 ± 0.041	0.392IleCys: 0.392 ± 0.01	2.926IleAsp: 2.926 ± 0.03	2.679IleGlu: 2.679 ± 0.03	1.24IlePhe: 1.24 ± 0.02	4.398IleGly: 4.398 ± 0.042	0.78IleHis: 0.78 ± 0.014	1.645IleIle: 1.645 ± 0.024	1.158IleLys: 1.158 ± 0.019	3.351IleLeu: 3.351 ± 0.038	0.726IleMet: 0.726 ± 0.014	1.046IleAsn: 1.046 ± 0.021	2.031IlePro: 2.031 ± 0.021	0.931IleGln: 0.931 ± 0.015	2.716IleArg: 2.716 ± 0.031	2.407IleSer: 2.407 ± 0.028	2.334IleThr: 2.334 ± 0.026	3.541IleVal: 3.541 ± 0.034	0.471IleTrp: 0.471 ± 0.01	0.814IleTyr: 0.814 ± 0.016	0.0IleXaa: 0.0 ± 0.0
Lys	3.928LysAla: 3.928 ± 0.043	0.127LysCys: 0.127 ± 0.006	1.671LysAsp: 1.671 ± 0.02	1.44LysGlu: 1.44 ± 0.022	0.726LysPhe: 0.726 ± 0.013	2.359LysGly: 2.359 ± 0.031	0.533LysHis: 0.533 ± 0.011	1.385LysIle: 1.385 ± 0.02	1.254LysLys: 1.254 ± 0.02	2.787LysLeu: 2.787 ± 0.035	0.631LysMet: 0.631 ± 0.015	0.763LysAsn: 0.763 ± 0.015	1.854LysPro: 1.854 ± 0.025	0.918LysGln: 0.918 ± 0.017	1.925LysArg: 1.925 ± 0.027	1.596LysSer: 1.596 ± 0.024	1.7LysThr: 1.7 ± 0.024	2.304LysVal: 2.304 ± 0.03	0.335LysTrp: 0.335 ± 0.01	0.556LysTyr: 0.556 ± 0.012	0.0LysXaa: 0.0 ± 0.0
Leu	13.954LeuAla: 13.954 ± 0.086	0.841LeuCys: 0.841 ± 0.016	6.47LeuAsp: 6.47 ± 0.047	4.852LeuGlu: 4.852 ± 0.04	3.126LeuPhe: 3.126 ± 0.033	8.82LeuGly: 8.82 ± 0.054	2.097LeuHis: 2.097 ± 0.027	4.052LeuIle: 4.052 ± 0.039	2.877LeuLys: 2.877 ± 0.036	10.369LeuLeu: 10.369 ± 0.076	1.962LeuMet: 1.962 ± 0.026	2.031LeuAsn: 2.031 ± 0.027	5.92LeuPro: 5.92 ± 0.045	2.382LeuGln: 2.382 ± 0.026	7.571LeuArg: 7.571 ± 0.052	5.956LeuSer: 5.956 ± 0.038	6.141LeuThr: 6.141 ± 0.044	8.317LeuVal: 8.317 ± 0.055	1.22LeuTrp: 1.22 ± 0.019	1.919LeuTyr: 1.919 ± 0.024	0.0LeuXaa: 0.0 ± 0.0
Met	2.725MetAla: 2.725 ± 0.026	0.139MetCys: 0.139 ± 0.006	1.036MetAsp: 1.036 ± 0.015	0.94MetGlu: 0.94 ± 0.016	0.604MetPhe: 0.604 ± 0.013	1.502MetGly: 1.502 ± 0.022	0.41MetHis: 0.41 ± 0.011	1.0MetIle: 1.0 ± 0.017	0.75MetLys: 0.75 ± 0.014	2.114MetLeu: 2.114 ± 0.026	0.474MetMet: 0.474 ± 0.012	0.633MetAsn: 0.633 ± 0.013	1.328MetPro: 1.328 ± 0.02	0.629MetGln: 0.629 ± 0.013	1.6MetArg: 1.6 ± 0.021	1.512MetSer: 1.512 ± 0.02	1.707MetThr: 1.707 ± 0.022	1.515MetVal: 1.515 ± 0.019	0.213MetTrp: 0.213 ± 0.007	0.309MetTyr: 0.309 ± 0.01	0.0MetXaa: 0.0 ± 0.0
Asn	2.717AsnAla: 2.717 ± 0.03	0.212AsnCys: 0.212 ± 0.008	1.195AsnAsp: 1.195 ± 0.018	1.016AsnGlu: 1.016 ± 0.019	0.745AsnPhe: 0.745 ± 0.015	2.195AsnGly: 2.195 ± 0.027	0.457AsnHis: 0.457 ± 0.011	1.013AsnIle: 1.013 ± 0.016	0.584AsnLys: 0.584 ± 0.014	2.052AsnLeu: 2.052 ± 0.024	0.474AsnMet: 0.474 ± 0.011	0.573AsnAsn: 0.573 ± 0.016	1.594AsnPro: 1.594 ± 0.022	0.646AsnGln: 0.646 ± 0.014	1.513AsnArg: 1.513 ± 0.021	1.144AsnSer: 1.144 ± 0.02	1.214AsnThr: 1.214 ± 0.022	1.625AsnVal: 1.625 ± 0.025	0.363AsnTrp: 0.363 ± 0.011	0.541AsnTyr: 0.541 ± 0.012	0.0AsnXaa: 0.0 ± 0.0
Pro	7.619ProAla: 7.619 ± 0.061	0.314ProCys: 0.314 ± 0.009	4.084ProAsp: 4.084 ± 0.037	3.898ProGlu: 3.898 ± 0.038	1.777ProPhe: 1.777 ± 0.019	5.772ProGly: 5.772 ± 0.041	1.189ProHis: 1.189 ± 0.02	1.648ProIle: 1.648 ± 0.022	1.488ProLys: 1.488 ± 0.021	5.076ProLeu: 5.076 ± 0.037	1.09ProMet: 1.09 ± 0.019	1.081ProAsn: 1.081 ± 0.019	2.924ProPro: 2.924 ± 0.04	1.682ProGln: 1.682 ± 0.022	3.362ProArg: 3.362 ± 0.034	3.076ProSer: 3.076 ± 0.031	2.724ProThr: 2.724 ± 0.029	5.04ProVal: 5.04 ± 0.037	0.8ProTrp: 0.8 ± 0.015	1.334ProTyr: 1.334 ± 0.02	0.0ProXaa: 0.0 ± 0.0
Gln	3.801GlnAla: 3.801 ± 0.035	0.181GlnCys: 0.181 ± 0.007	1.47GlnAsp: 1.47 ± 0.019	1.482GlnGlu: 1.482 ± 0.024	0.866GlnPhe: 0.866 ± 0.015	2.324GlnGly: 2.324 ± 0.025	0.635GlnHis: 0.635 ± 0.013	1.373GlnIle: 1.373 ± 0.022	0.902GlnLys: 0.902 ± 0.019	2.907GlnLeu: 2.907 ± 0.027	0.656GlnMet: 0.656 ± 0.016	0.702GlnAsn: 0.702 ± 0.014	1.677GlnPro: 1.677 ± 0.024	1.23GlnGln: 1.23 ± 0.027	2.217GlnArg: 2.217 ± 0.025	1.472GlnSer: 1.472 ± 0.016	1.463GlnThr: 1.463 ± 0.02	2.18GlnVal: 2.18 ± 0.025	0.423GlnTrp: 0.423 ± 0.01	0.593GlnTyr: 0.593 ± 0.014	0.0GlnXaa: 0.0 ± 0.0
Arg	8.622ArgAla: 8.622 ± 0.058	0.519ArgCys: 0.519 ± 0.014	4.118ArgAsp: 4.118 ± 0.037	4.283ArgGlu: 4.283 ± 0.036	2.543ArgPhe: 2.543 ± 0.027	5.344ArgGly: 5.344 ± 0.04	1.871ArgHis: 1.871 ± 0.025	3.634ArgIle: 3.634 ± 0.029	2.09ArgLys: 2.09 ± 0.024	8.031ArgLeu: 8.031 ± 0.056	1.802ArgMet: 1.802 ± 0.022	1.664ArgAsn: 1.664 ± 0.021	4.22ArgPro: 4.22 ± 0.039	2.391ArgGln: 2.391 ± 0.028	6.593ArgArg: 6.593 ± 0.059	4.04ArgSer: 4.04 ± 0.035	4.746ArgThr: 4.746 ± 0.038	5.075ArgVal: 5.075 ± 0.038	1.156ArgTrp: 1.156 ± 0.018	1.722ArgTyr: 1.722 ± 0.02	0.0ArgXaa: 0.0 ± 0.0
Ser	6.701SerAla: 6.701 ± 0.049	0.418SerCys: 0.418 ± 0.012	3.01SerAsp: 3.01 ± 0.032	2.665SerGlu: 2.665 ± 0.028	1.93SerPhe: 1.93 ± 0.024	6.104SerGly: 6.104 ± 0.044	1.094SerHis: 1.094 ± 0.017	2.162SerIle: 2.162 ± 0.027	1.413SerLys: 1.413 ± 0.02	5.252SerLeu: 5.252 ± 0.037	1.24SerMet: 1.24 ± 0.017	1.152SerAsn: 1.152 ± 0.019	3.07SerPro: 3.07 ± 0.031	1.422SerGln: 1.422 ± 0.022	3.762SerArg: 3.762 ± 0.031	3.101SerSer: 3.101 ± 0.033	3.028SerThr: 3.028 ± 0.03	4.438SerVal: 4.438 ± 0.041	0.885SerTrp: 0.885 ± 0.015	1.285SerTyr: 1.285 ± 0.018	0.0SerXaa: 0.0 ± 0.0
Thr	7.771ThrAla: 7.771 ± 0.06	0.396ThrCys: 0.396 ± 0.011	3.322ThrAsp: 3.322 ± 0.034	3.03ThrGlu: 3.03 ± 0.031	1.848ThrPhe: 1.848 ± 0.024	6.151ThrGly: 6.151 ± 0.055	1.109ThrHis: 1.109 ± 0.018	2.296ThrIle: 2.296 ± 0.027	1.413ThrLys: 1.413 ± 0.018	5.662ThrLeu: 5.662 ± 0.041	1.105ThrMet: 1.105 ± 0.019	1.154ThrAsn: 1.154 ± 0.017	3.571ThrPro: 3.571 ± 0.033	1.337ThrGln: 1.337 ± 0.018	3.569ThrArg: 3.569 ± 0.035	3.124ThrSer: 3.124 ± 0.028	3.436ThrThr: 3.436 ± 0.036	5.457ThrVal: 5.457 ± 0.046	0.809ThrTrp: 0.809 ± 0.014	1.283ThrTyr: 1.283 ± 0.018	0.0ThrXaa: 0.0 ± 0.0
Val	10.015ValAla: 10.015 ± 0.06	0.692ValCys: 0.692 ± 0.015	4.641ValAsp: 4.641 ± 0.04	4.614ValGlu: 4.614 ± 0.033	2.658ValPhe: 2.658 ± 0.026	6.103ValGly: 6.103 ± 0.043	1.727ValHis: 1.727 ± 0.022	3.338ValIle: 3.338 ± 0.036	2.135ValLys: 2.135 ± 0.026	8.685ValLeu: 8.685 ± 0.064	1.64ValMet: 1.64 ± 0.025	1.764ValAsn: 1.764 ± 0.025	4.676ValPro: 4.676 ± 0.04	2.036ValGln: 2.036 ± 0.025	6.128ValArg: 6.128 ± 0.042	4.586ValSer: 4.586 ± 0.041	5.185ValThr: 5.185 ± 0.042	7.143ValVal: 7.143 ± 0.055	1.026ValTrp: 1.026 ± 0.018	1.528ValTyr: 1.528 ± 0.019	0.0ValXaa: 0.0 ± 0.0
Trp	1.447TrpAla: 1.447 ± 0.021	0.144TrpCys: 0.144 ± 0.007	0.724TrpAsp: 0.724 ± 0.013	0.64TrpGlu: 0.64 ± 0.013	0.518TrpPhe: 0.518 ± 0.012	0.974TrpGly: 0.974 ± 0.017	0.339TrpHis: 0.339 ± 0.01	0.606TrpIle: 0.606 ± 0.013	0.446TrpLys: 0.446 ± 0.01	1.664TrpLeu: 1.664 ± 0.02	0.318TrpMet: 0.318 ± 0.01	0.442TrpAsn: 0.442 ± 0.011	0.747TrpPro: 0.747 ± 0.015	0.609TrpGln: 0.609 ± 0.013	1.177TrpArg: 1.177 ± 0.017	0.921TrpSer: 0.921 ± 0.017	0.94TrpThr: 0.94 ± 0.015	0.887TrpVal: 0.887 ± 0.013	0.288TrpTrp: 0.288 ± 0.008	0.335TrpTyr: 0.335 ± 0.01	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.639TyrAla: 2.639 ± 0.026	0.209TyrCys: 0.209 ± 0.006	1.461TyrAsp: 1.461 ± 0.023	1.226TyrGlu: 1.226 ± 0.021	0.785TyrPhe: 0.785 ± 0.015	2.194TyrGly: 2.194 ± 0.029	0.437TyrHis: 0.437 ± 0.01	0.704TyrIle: 0.704 ± 0.015	0.535TyrLys: 0.535 ± 0.012	2.151TyrLeu: 2.151 ± 0.026	0.35TyrMet: 0.35 ± 0.009	0.496TyrAsn: 0.496 ± 0.012	1.059TyrPro: 1.059 ± 0.019	0.65TyrGln: 0.65 ± 0.015	1.787TyrArg: 1.787 ± 0.022	1.075TyrSer: 1.075 ± 0.015	1.197TyrThr: 1.197 ± 0.017	1.665TyrVal: 1.665 ± 0.023	0.337TyrTrp: 0.337 ± 0.01	0.513TyrTyr: 0.513 ± 0.012	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 12366 proteins (3950924 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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