Amino acid dipepetide frequency for Zeaxanthinibacter enoshimensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	5.604AlaAla: 5.604 ± 0.111	0.573AlaCys: 0.573 ± 0.028	4.111AlaAsp: 4.111 ± 0.075	4.966AlaGlu: 4.966 ± 0.08	3.285AlaPhe: 3.285 ± 0.061	5.465AlaGly: 5.465 ± 0.117	1.298AlaHis: 1.298 ± 0.039	5.132AlaIle: 5.132 ± 0.087	3.883AlaLys: 3.883 ± 0.088	7.027AlaLeu: 7.027 ± 0.094	1.923AlaMet: 1.923 ± 0.049	3.037AlaAsn: 3.037 ± 0.059	2.284AlaPro: 2.284 ± 0.065	2.512AlaGln: 2.512 ± 0.059	3.132AlaArg: 3.132 ± 0.062	4.287AlaSer: 4.287 ± 0.077	3.872AlaThr: 3.872 ± 0.097	4.899AlaVal: 4.899 ± 0.08	0.747AlaTrp: 0.747 ± 0.03	2.7AlaTyr: 2.7 ± 0.057	0.0AlaXaa: 0.0 ± 0.0
Cys	0.492CysAla: 0.492 ± 0.027	0.124CysCys: 0.124 ± 0.012	0.397CysAsp: 0.397 ± 0.025	0.431CysGlu: 0.431 ± 0.023	0.345CysPhe: 0.345 ± 0.021	0.663CysGly: 0.663 ± 0.028	0.19CysHis: 0.19 ± 0.016	0.518CysIle: 0.518 ± 0.025	0.398CysLys: 0.398 ± 0.023	0.682CysLeu: 0.682 ± 0.026	0.166CysMet: 0.166 ± 0.013	0.353CysAsn: 0.353 ± 0.023	0.365CysPro: 0.365 ± 0.027	0.206CysGln: 0.206 ± 0.016	0.295CysArg: 0.295 ± 0.019	0.545CysSer: 0.545 ± 0.03	0.469CysThr: 0.469 ± 0.03	0.403CysVal: 0.403 ± 0.022	0.067CysTrp: 0.067 ± 0.009	0.304CysTyr: 0.304 ± 0.019	0.0CysXaa: 0.0 ± 0.0
Asp	3.987AspAla: 3.987 ± 0.086	0.396AspCys: 0.396 ± 0.021	2.946AspAsp: 2.946 ± 0.107	3.874AspGlu: 3.874 ± 0.072	3.447AspPhe: 3.447 ± 0.073	4.437AspGly: 4.437 ± 0.182	1.232AspHis: 1.232 ± 0.042	4.126AspIle: 4.126 ± 0.076	3.708AspLys: 3.708 ± 0.09	5.693AspLeu: 5.693 ± 0.085	1.303AspMet: 1.303 ± 0.044	2.908AspAsn: 2.908 ± 0.109	2.672AspPro: 2.672 ± 0.063	2.029AspGln: 2.029 ± 0.058	2.674AspArg: 2.674 ± 0.059	3.46AspSer: 3.46 ± 0.078	3.109AspThr: 3.109 ± 0.094	3.277AspVal: 3.277 ± 0.063	0.78AspTrp: 0.78 ± 0.032	2.7AspTyr: 2.7 ± 0.06	0.0AspXaa: 0.0 ± 0.0
Glu	5.052GluAla: 5.052 ± 0.084	0.361GluCys: 0.361 ± 0.022	4.18GluAsp: 4.18 ± 0.074	6.071GluGlu: 6.071 ± 0.104	2.888GluPhe: 2.888 ± 0.052	4.489GluGly: 4.489 ± 0.071	1.366GluHis: 1.366 ± 0.036	5.166GluIle: 5.166 ± 0.087	5.406GluLys: 5.406 ± 0.109	6.822GluLeu: 6.822 ± 0.103	1.746GluMet: 1.746 ± 0.043	3.774GluAsn: 3.774 ± 0.065	2.042GluPro: 2.042 ± 0.044	2.875GluGln: 2.875 ± 0.06	3.176GluArg: 3.176 ± 0.074	3.461GluSer: 3.461 ± 0.065	3.618GluThr: 3.618 ± 0.065	4.931GluVal: 4.931 ± 0.076	0.727GluTrp: 0.727 ± 0.028	2.47GluTyr: 2.47 ± 0.048	0.0GluXaa: 0.0 ± 0.0
Phe	2.91PheAla: 2.91 ± 0.069	0.41PheCys: 0.41 ± 0.021	2.968PheAsp: 2.968 ± 0.063	3.129PheGlu: 3.129 ± 0.058	2.389PhePhe: 2.389 ± 0.066	3.497PheGly: 3.497 ± 0.066	0.857PheHis: 0.857 ± 0.034	3.163PheIle: 3.163 ± 0.071	2.79PheLys: 2.79 ± 0.058	4.782PheLeu: 4.782 ± 0.085	1.182PheMet: 1.182 ± 0.04	2.609PheAsn: 2.609 ± 0.058	1.841PhePro: 1.841 ± 0.039	1.459PheGln: 1.459 ± 0.038	2.373PheArg: 2.373 ± 0.056	3.583PheSer: 3.583 ± 0.064	2.979PheThr: 2.979 ± 0.08	2.66PheVal: 2.66 ± 0.058	0.573PheTrp: 0.573 ± 0.024	2.038PheTyr: 2.038 ± 0.048	0.0PheXaa: 0.0 ± 0.0
Gly	4.878GlyAla: 4.878 ± 0.103	0.692GlyCys: 0.692 ± 0.058	4.237GlyAsp: 4.237 ± 0.145	4.547GlyGlu: 4.547 ± 0.09	3.582GlyPhe: 3.582 ± 0.071	5.118GlyGly: 5.118 ± 0.112	1.357GlyHis: 1.357 ± 0.048	5.822GlyIle: 5.822 ± 0.073	5.051GlyLys: 5.051 ± 0.086	6.483GlyLeu: 6.483 ± 0.088	1.958GlyMet: 1.958 ± 0.049	3.663GlyAsn: 3.663 ± 0.115	2.086GlyPro: 2.086 ± 0.24	2.318GlyGln: 2.318 ± 0.054	2.741GlyArg: 2.741 ± 0.06	4.523GlySer: 4.523 ± 0.093	4.357GlyThr: 4.357 ± 0.142	4.53GlyVal: 4.53 ± 0.082	0.894GlyTrp: 0.894 ± 0.034	2.971GlyTyr: 2.971 ± 0.066	0.0GlyXaa: 0.0 ± 0.0
His	1.134HisAla: 1.134 ± 0.037	0.2HisCys: 0.2 ± 0.016	0.87HisAsp: 0.87 ± 0.029	1.107HisGlu: 1.107 ± 0.039	1.109HisPhe: 1.109 ± 0.038	1.287HisGly: 1.287 ± 0.039	0.509HisHis: 0.509 ± 0.025	1.313HisIle: 1.313 ± 0.04	1.142HisLys: 1.142 ± 0.037	2.048HisLeu: 2.048 ± 0.049	0.407HisMet: 0.407 ± 0.026	0.815HisAsn: 0.815 ± 0.03	1.117HisPro: 1.117 ± 0.036	0.761HisGln: 0.761 ± 0.03	0.926HisArg: 0.926 ± 0.03	1.09HisSer: 1.09 ± 0.04	1.012HisThr: 1.012 ± 0.032	1.005HisVal: 1.005 ± 0.035	0.293HisTrp: 0.293 ± 0.018	0.917HisTyr: 0.917 ± 0.034	0.0HisXaa: 0.0 ± 0.0
Ile	5.389IleAla: 5.389 ± 0.084	0.554IleCys: 0.554 ± 0.024	4.153IleAsp: 4.153 ± 0.076	4.412IleGlu: 4.412 ± 0.098	3.149IlePhe: 3.149 ± 0.063	4.688IleGly: 4.688 ± 0.078	1.282IleHis: 1.282 ± 0.038	4.391IleIle: 4.391 ± 0.09	3.786IleLys: 3.786 ± 0.076	6.75IleLeu: 6.75 ± 0.11	1.359IleMet: 1.359 ± 0.039	3.362IleAsn: 3.362 ± 0.056	3.422IlePro: 3.422 ± 0.062	2.249IleGln: 2.249 ± 0.061	3.454IleArg: 3.454 ± 0.056	4.986IleSer: 4.986 ± 0.101	4.169IleThr: 4.169 ± 0.076	3.928IleVal: 3.928 ± 0.066	0.628IleTrp: 0.628 ± 0.023	2.417IleTyr: 2.417 ± 0.057	0.0IleXaa: 0.0 ± 0.0
Lys	4.683LysAla: 4.683 ± 0.087	0.257LysCys: 0.257 ± 0.016	4.005LysAsp: 4.005 ± 0.07	5.453LysGlu: 5.453 ± 0.11	2.344LysPhe: 2.344 ± 0.053	4.28LysGly: 4.28 ± 0.122	1.19LysHis: 1.19 ± 0.037	4.399LysIle: 4.399 ± 0.087	5.216LysLys: 5.216 ± 0.112	5.343LysLeu: 5.343 ± 0.087	1.652LysMet: 1.652 ± 0.041	3.323LysAsn: 3.323 ± 0.063	2.212LysPro: 2.212 ± 0.049	2.159LysGln: 2.159 ± 0.054	2.765LysArg: 2.765 ± 0.06	3.426LysSer: 3.426 ± 0.064	3.445LysThr: 3.445 ± 0.074	4.129LysVal: 4.129 ± 0.084	0.636LysTrp: 0.636 ± 0.025	2.284LysTyr: 2.284 ± 0.047	0.0LysXaa: 0.0 ± 0.0
Leu	6.82LeuAla: 6.82 ± 0.087	0.737LeuCys: 0.737 ± 0.029	5.637LeuAsp: 5.637 ± 0.101	6.957LeuGlu: 6.957 ± 0.108	4.57LeuPhe: 4.57 ± 0.082	6.65LeuGly: 6.65 ± 0.118	1.805LeuHis: 1.805 ± 0.049	5.979LeuIle: 5.979 ± 0.096	6.395LeuLys: 6.395 ± 0.107	10.283LeuLeu: 10.283 ± 0.166	2.346LeuMet: 2.346 ± 0.055	4.618LeuAsn: 4.618 ± 0.083	4.087LeuPro: 4.087 ± 0.058	3.928LeuGln: 3.928 ± 0.076	4.21LeuArg: 4.21 ± 0.085	6.573LeuSer: 6.573 ± 0.095	4.834LeuThr: 4.834 ± 0.075	6.231LeuVal: 6.231 ± 0.093	0.95LeuTrp: 0.95 ± 0.032	3.361LeuTyr: 3.361 ± 0.068	0.0LeuXaa: 0.0 ± 0.0
Met	2.013MetAla: 2.013 ± 0.046	0.14MetCys: 0.14 ± 0.014	1.414MetAsp: 1.414 ± 0.039	1.858MetGlu: 1.858 ± 0.047	0.797MetPhe: 0.797 ± 0.029	1.757MetGly: 1.757 ± 0.049	0.456MetHis: 0.456 ± 0.022	1.556MetIle: 1.556 ± 0.045	2.049MetLys: 2.049 ± 0.048	2.144MetLeu: 2.144 ± 0.052	0.637MetMet: 0.637 ± 0.029	1.29MetAsn: 1.29 ± 0.034	1.005MetPro: 1.005 ± 0.033	0.95MetGln: 0.95 ± 0.035	1.081MetArg: 1.081 ± 0.038	1.375MetSer: 1.375 ± 0.045	1.193MetThr: 1.193 ± 0.039	1.66MetVal: 1.66 ± 0.047	0.172MetTrp: 0.172 ± 0.013	0.719MetTyr: 0.719 ± 0.028	0.0MetXaa: 0.0 ± 0.0
Asn	3.361AsnAla: 3.361 ± 0.075	0.375AsnCys: 0.375 ± 0.024	2.666AsnAsp: 2.666 ± 0.1	2.868AsnGlu: 2.868 ± 0.059	2.589AsnPhe: 2.589 ± 0.056	3.58AsnGly: 3.58 ± 0.115	0.846AsnHis: 0.846 ± 0.033	3.425AsnIle: 3.425 ± 0.066	2.857AsnLys: 2.857 ± 0.06	4.473AsnLeu: 4.473 ± 0.07	1.174AsnMet: 1.174 ± 0.033	2.54AsnAsn: 2.54 ± 0.078	2.611AsnPro: 2.611 ± 0.053	1.756AsnGln: 1.756 ± 0.045	2.251AsnArg: 2.251 ± 0.056	3.07AsnSer: 3.07 ± 0.061	3.025AsnThr: 3.025 ± 0.076	2.812AsnVal: 2.812 ± 0.066	0.655AsnTrp: 0.655 ± 0.026	2.233AsnTyr: 2.233 ± 0.058	0.0AsnXaa: 0.0 ± 0.0
Pro	2.809ProAla: 2.809 ± 0.064	0.23ProCys: 0.23 ± 0.014	2.795ProAsp: 2.795 ± 0.082	3.703ProGlu: 3.703 ± 0.06	1.92ProPhe: 1.92 ± 0.043	3.232ProGly: 3.232 ± 0.065	0.717ProHis: 0.717 ± 0.026	2.207ProIle: 2.207 ± 0.049	2.049ProLys: 2.049 ± 0.049	3.508ProLeu: 3.508 ± 0.06	0.96ProMet: 0.96 ± 0.029	1.71ProAsn: 1.71 ± 0.044	1.163ProPro: 1.163 ± 0.04	1.409ProGln: 1.409 ± 0.134	1.48ProArg: 1.48 ± 0.046	2.244ProSer: 2.244 ± 0.053	1.879ProThr: 1.879 ± 0.055	3.149ProVal: 3.149 ± 0.06	0.443ProTrp: 0.443 ± 0.025	1.587ProTyr: 1.587 ± 0.053	0.0ProXaa: 0.0 ± 0.0
Gln	2.478GlnAla: 2.478 ± 0.058	0.226GlnCys: 0.226 ± 0.017	2.007GlnAsp: 2.007 ± 0.046	2.83GlnGlu: 2.83 ± 0.067	1.595GlnPhe: 1.595 ± 0.044	2.625GlnGly: 2.625 ± 0.238	0.68GlnHis: 0.68 ± 0.026	2.154GlnIle: 2.154 ± 0.045	2.261GlnLys: 2.261 ± 0.055	3.903GlnLeu: 3.903 ± 0.063	0.901GlnMet: 0.901 ± 0.029	1.583GlnAsn: 1.583 ± 0.044	1.312GlnPro: 1.312 ± 0.033	1.88GlnGln: 1.88 ± 0.059	1.604GlnArg: 1.604 ± 0.041	1.769GlnSer: 1.769 ± 0.051	1.68GlnThr: 1.68 ± 0.043	2.5GlnVal: 2.5 ± 0.051	0.429GlnTrp: 0.429 ± 0.024	1.429GlnTyr: 1.429 ± 0.035	0.0GlnXaa: 0.0 ± 0.0
Arg	2.786ArgAla: 2.786 ± 0.046	0.229ArgCys: 0.229 ± 0.016	2.626ArgAsp: 2.626 ± 0.059	3.527ArgGlu: 3.527 ± 0.072	2.213ArgPhe: 2.213 ± 0.047	2.508ArgGly: 2.508 ± 0.054	0.825ArgHis: 0.825 ± 0.035	3.456ArgIle: 3.456 ± 0.062	3.286ArgLys: 3.286 ± 0.07	4.142ArgLeu: 4.142 ± 0.081	1.219ArgMet: 1.219 ± 0.033	2.456ArgAsn: 2.456 ± 0.056	1.508ArgPro: 1.508 ± 0.042	1.728ArgGln: 1.728 ± 0.047	1.858ArgArg: 1.858 ± 0.052	2.808ArgSer: 2.808 ± 0.069	2.3ArgThr: 2.3 ± 0.049	2.782ArgVal: 2.782 ± 0.059	0.539ArgTrp: 0.539 ± 0.023	1.942ArgTyr: 1.942 ± 0.042	0.0ArgXaa: 0.0 ± 0.0
Ser	4.126SerAla: 4.126 ± 0.067	0.666SerCys: 0.666 ± 0.033	3.402SerAsp: 3.402 ± 0.066	4.075SerGlu: 4.075 ± 0.069	3.325SerPhe: 3.325 ± 0.064	5.281SerGly: 5.281 ± 0.105	1.079SerHis: 1.079 ± 0.035	3.952SerIle: 3.952 ± 0.06	3.489SerLys: 3.489 ± 0.066	6.179SerLeu: 6.179 ± 0.097	1.469SerMet: 1.469 ± 0.044	2.663SerAsn: 2.663 ± 0.071	2.477SerPro: 2.477 ± 0.057	1.989SerGln: 1.989 ± 0.047	3.044SerArg: 3.044 ± 0.065	3.904SerSer: 3.904 ± 0.084	3.2SerThr: 3.2 ± 0.066	3.965SerVal: 3.965 ± 0.064	0.774SerTrp: 0.774 ± 0.029	2.616SerTyr: 2.616 ± 0.057	0.0SerXaa: 0.0 ± 0.0
Thr	4.227ThrAla: 4.227 ± 0.084	0.311ThrCys: 0.311 ± 0.02	3.516ThrAsp: 3.516 ± 0.13	3.532ThrGlu: 3.532 ± 0.067	2.679ThrPhe: 2.679 ± 0.065	4.605ThrGly: 4.605 ± 0.143	1.005ThrHis: 1.005 ± 0.034	3.946ThrIle: 3.946 ± 0.085	2.57ThrLys: 2.57 ± 0.06	5.324ThrLeu: 5.324 ± 0.092	1.111ThrMet: 1.111 ± 0.036	2.479ThrAsn: 2.479 ± 0.087	2.461ThrPro: 2.461 ± 0.067	1.623ThrGln: 1.623 ± 0.045	2.295ThrArg: 2.295 ± 0.046	3.173ThrSer: 3.173 ± 0.073	3.1ThrThr: 3.1 ± 0.074	4.025ThrVal: 4.025 ± 0.11	0.53ThrTrp: 0.53 ± 0.023	2.412ThrTyr: 2.412 ± 0.08	0.0ThrXaa: 0.0 ± 0.0
Val	4.717ValAla: 4.717 ± 0.081	0.492ValCys: 0.492 ± 0.021	3.686ValAsp: 3.686 ± 0.067	3.946ValGlu: 3.946 ± 0.063	3.242ValPhe: 3.242 ± 0.062	4.036ValGly: 4.036 ± 0.081	1.22ValHis: 1.22 ± 0.033	4.733ValIle: 4.733 ± 0.078	3.782ValLys: 3.782 ± 0.082	6.415ValLeu: 6.415 ± 0.093	1.586ValMet: 1.586 ± 0.042	3.343ValAsn: 3.343 ± 0.073	2.615ValPro: 2.615 ± 0.047	2.022ValGln: 2.022 ± 0.048	2.754ValArg: 2.754 ± 0.051	4.304ValSer: 4.304 ± 0.07	3.76ValThr: 3.76 ± 0.112	4.481ValVal: 4.481 ± 0.083	0.598ValTrp: 0.598 ± 0.025	2.402ValTyr: 2.402 ± 0.053	0.0ValXaa: 0.0 ± 0.0
Trp	0.686TrpAla: 0.686 ± 0.026	0.082TrpCys: 0.082 ± 0.009	0.725TrpAsp: 0.725 ± 0.031	0.781TrpGlu: 0.781 ± 0.03	0.54TrpPhe: 0.54 ± 0.025	0.762TrpGly: 0.762 ± 0.031	0.263TrpHis: 0.263 ± 0.016	0.752TrpIle: 0.752 ± 0.03	0.742TrpLys: 0.742 ± 0.029	1.007TrpLeu: 1.007 ± 0.032	0.339TrpMet: 0.339 ± 0.021	0.634TrpAsn: 0.634 ± 0.029	0.31TrpPro: 0.31 ± 0.018	0.455TrpGln: 0.455 ± 0.022	0.499TrpArg: 0.499 ± 0.025	0.651TrpSer: 0.651 ± 0.025	0.539TrpThr: 0.539 ± 0.024	0.713TrpVal: 0.713 ± 0.028	0.18TrpTrp: 0.18 ± 0.016	0.451TrpTyr: 0.451 ± 0.021	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.586TyrAla: 2.586 ± 0.055	0.357TyrCys: 0.357 ± 0.02	2.415TyrAsp: 2.415 ± 0.057	2.554TyrGlu: 2.554 ± 0.053	2.182TyrPhe: 2.182 ± 0.047	2.847TyrGly: 2.847 ± 0.066	0.885TyrHis: 0.885 ± 0.034	2.343TyrIle: 2.343 ± 0.047	2.34TyrLys: 2.34 ± 0.056	3.962TyrLeu: 3.962 ± 0.079	0.827TyrMet: 0.827 ± 0.03	2.007TyrAsn: 2.007 ± 0.052	1.606TyrPro: 1.606 ± 0.039	1.536TyrGln: 1.536 ± 0.049	2.125TyrArg: 2.125 ± 0.05	2.441TyrSer: 2.441 ± 0.048	2.385TyrThr: 2.385 ± 0.08	2.054TyrVal: 2.054 ± 0.051	0.499TyrTrp: 0.499 ± 0.021	1.701TyrTyr: 1.701 ± 0.05	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2926 proteins (1007827 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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