Amino acid dipepetide frequency for Egibacter rhizosphaerae

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	20.637AlaAla: 20.637 ± 0.191	1.113AlaCys: 1.113 ± 0.034	9.301AlaAsp: 9.301 ± 0.105	9.759AlaGlu: 9.759 ± 0.114	3.73AlaPhe: 3.73 ± 0.062	13.304AlaGly: 13.304 ± 0.13	3.166AlaHis: 3.166 ± 0.045	4.617AlaIle: 4.617 ± 0.061	1.49AlaLys: 1.49 ± 0.039	14.464AlaLeu: 14.464 ± 0.133	2.481AlaMet: 2.481 ± 0.05	1.871AlaAsn: 1.871 ± 0.034	6.674AlaPro: 6.674 ± 0.078	3.528AlaGln: 3.528 ± 0.05	11.7AlaArg: 11.7 ± 0.127	6.535AlaSer: 6.535 ± 0.082	7.516AlaThr: 7.516 ± 0.082	11.809AlaVal: 11.809 ± 0.112	1.975AlaTrp: 1.975 ± 0.038	2.234AlaTyr: 2.234 ± 0.039	0.0AlaXaa: 0.0 ± 0.0
Cys	0.934CysAla: 0.934 ± 0.027	0.105CysCys: 0.105 ± 0.009	0.531CysAsp: 0.531 ± 0.02	0.511CysGlu: 0.511 ± 0.019	0.18CysPhe: 0.18 ± 0.011	0.837CysGly: 0.837 ± 0.025	0.212CysHis: 0.212 ± 0.014	0.186CysIle: 0.186 ± 0.013	0.079CysLys: 0.079 ± 0.008	0.543CysLeu: 0.543 ± 0.021	0.096CysMet: 0.096 ± 0.008	0.131CysAsn: 0.131 ± 0.009	0.529CysPro: 0.529 ± 0.022	0.151CysGln: 0.151 ± 0.011	0.671CysArg: 0.671 ± 0.025	0.353CysSer: 0.353 ± 0.017	0.368CysThr: 0.368 ± 0.017	0.528CysVal: 0.528 ± 0.021	0.118CysTrp: 0.118 ± 0.01	0.166CysTyr: 0.166 ± 0.011	0.0CysXaa: 0.0 ± 0.0
Asp	9.539AspAla: 9.539 ± 0.104	0.373AspCys: 0.373 ± 0.016	5.612AspAsp: 5.612 ± 0.134	6.581AspGlu: 6.581 ± 0.124	1.418AspPhe: 1.418 ± 0.034	7.126AspGly: 7.126 ± 0.099	1.645AspHis: 1.645 ± 0.038	1.665AspIle: 1.665 ± 0.041	0.602AspLys: 0.602 ± 0.023	7.07AspLeu: 7.07 ± 0.084	0.728AspMet: 0.728 ± 0.028	0.718AspAsn: 0.718 ± 0.028	5.718AspPro: 5.718 ± 0.081	1.61AspGln: 1.61 ± 0.038	6.186AspArg: 6.186 ± 0.073	2.04AspSer: 2.04 ± 0.045	3.019AspThr: 3.019 ± 0.065	5.852AspVal: 5.852 ± 0.073	0.933AspTrp: 0.933 ± 0.029	1.043AspTyr: 1.043 ± 0.031	0.0AspXaa: 0.0 ± 0.0
Glu	9.825GluAla: 9.825 ± 0.12	0.314GluCys: 0.314 ± 0.016	4.154GluAsp: 4.154 ± 0.097	5.11GluGlu: 5.11 ± 0.105	1.612GluPhe: 1.612 ± 0.045	5.799GluGly: 5.799 ± 0.075	1.971GluHis: 1.971 ± 0.042	2.48GluIle: 2.48 ± 0.05	0.684GluLys: 0.684 ± 0.026	8.301GluLeu: 8.301 ± 0.094	0.998GluMet: 0.998 ± 0.032	0.876GluAsn: 0.876 ± 0.029	5.005GluPro: 5.005 ± 0.082	2.872GluGln: 2.872 ± 0.052	7.385GluArg: 7.385 ± 0.1	2.498GluSer: 2.498 ± 0.05	3.217GluThr: 3.217 ± 0.046	6.464GluVal: 6.464 ± 0.083	0.868GluTrp: 0.868 ± 0.027	0.926GluTyr: 0.926 ± 0.026	0.0GluXaa: 0.0 ± 0.0
Phe	3.724PheAla: 3.724 ± 0.063	0.229PheCys: 0.229 ± 0.013	2.072PheAsp: 2.072 ± 0.046	1.805PheGlu: 1.805 ± 0.043	0.761PhePhe: 0.761 ± 0.025	2.935PheGly: 2.935 ± 0.053	0.525PheHis: 0.525 ± 0.019	0.715PheIle: 0.715 ± 0.023	0.308PheLys: 0.308 ± 0.015	2.371PheLeu: 2.371 ± 0.046	0.364PheMet: 0.364 ± 0.018	0.487PheAsn: 0.487 ± 0.021	1.314PhePro: 1.314 ± 0.027	0.589PheGln: 0.589 ± 0.022	1.651PheArg: 1.651 ± 0.035	1.176PheSer: 1.176 ± 0.03	1.466PheThr: 1.466 ± 0.031	2.45PheVal: 2.45 ± 0.046	0.384PheTrp: 0.384 ± 0.018	0.518PheTyr: 0.518 ± 0.022	0.0PheXaa: 0.0 ± 0.0
Gly	11.488GlyAla: 11.488 ± 0.109	0.822GlyCys: 0.822 ± 0.03	6.172GlyAsp: 6.172 ± 0.088	7.017GlyGlu: 7.017 ± 0.092	2.788GlyPhe: 2.788 ± 0.049	8.86GlyGly: 8.86 ± 0.113	2.316GlyHis: 2.316 ± 0.036	3.456GlyIle: 3.456 ± 0.056	1.455GlyLys: 1.455 ± 0.042	9.754GlyLeu: 9.754 ± 0.113	1.919GlyMet: 1.919 ± 0.045	1.415GlyAsn: 1.415 ± 0.031	5.109GlyPro: 5.109 ± 0.071	2.699GlyGln: 2.699 ± 0.044	7.715GlyArg: 7.715 ± 0.095	5.024GlySer: 5.024 ± 0.068	5.371GlyThr: 5.371 ± 0.075	8.13GlyVal: 8.13 ± 0.093	1.7GlyTrp: 1.7 ± 0.035	1.971GlyTyr: 1.971 ± 0.038	0.0GlyXaa: 0.0 ± 0.0
His	3.166HisAla: 3.166 ± 0.055	0.183HisCys: 0.183 ± 0.011	1.712HisAsp: 1.712 ± 0.042	1.736HisGlu: 1.736 ± 0.04	0.521HisPhe: 0.521 ± 0.017	2.507HisGly: 2.507 ± 0.049	0.758HisHis: 0.758 ± 0.026	0.514HisIle: 0.514 ± 0.018	0.269HisLys: 0.269 ± 0.015	2.484HisLeu: 2.484 ± 0.047	0.272HisMet: 0.272 ± 0.016	0.325HisAsn: 0.325 ± 0.015	1.745HisPro: 1.745 ± 0.042	0.612HisGln: 0.612 ± 0.024	2.224HisArg: 2.224 ± 0.041	0.772HisSer: 0.772 ± 0.024	1.121HisThr: 1.121 ± 0.031	2.098HisVal: 2.098 ± 0.041	0.33HisTrp: 0.33 ± 0.015	0.416HisTyr: 0.416 ± 0.019	0.0HisXaa: 0.0 ± 0.0
Ile	5.207IleAla: 5.207 ± 0.064	0.206IleCys: 0.206 ± 0.012	2.872IleAsp: 2.872 ± 0.05	2.498IleGlu: 2.498 ± 0.047	0.694IlePhe: 0.694 ± 0.025	3.415IleGly: 3.415 ± 0.057	0.643IleHis: 0.643 ± 0.023	0.915IleIle: 0.915 ± 0.032	0.41IleLys: 0.41 ± 0.021	2.397IleLeu: 2.397 ± 0.052	0.43IleMet: 0.43 ± 0.019	0.55IleAsn: 0.55 ± 0.022	1.625IlePro: 1.625 ± 0.04	0.649IleGln: 0.649 ± 0.019	2.059IleArg: 2.059 ± 0.042	1.401IleSer: 1.401 ± 0.036	1.771IleThr: 1.771 ± 0.035	3.235IleVal: 3.235 ± 0.055	0.291IleTrp: 0.291 ± 0.017	0.524IleTyr: 0.524 ± 0.022	0.0IleXaa: 0.0 ± 0.0
Lys	1.457LysAla: 1.457 ± 0.038	0.062LysCys: 0.062 ± 0.006	0.596LysAsp: 0.596 ± 0.022	0.634LysGlu: 0.634 ± 0.024	0.252LysPhe: 0.252 ± 0.014	1.061LysGly: 1.061 ± 0.035	0.291LysHis: 0.291 ± 0.015	0.415LysIle: 0.415 ± 0.017	0.248LysLys: 0.248 ± 0.016	1.211LysLeu: 1.211 ± 0.037	0.187LysMet: 0.187 ± 0.011	0.207LysAsn: 0.207 ± 0.014	0.703LysPro: 0.703 ± 0.026	0.428LysGln: 0.428 ± 0.021	1.07LysArg: 1.07 ± 0.03	0.584LysSer: 0.584 ± 0.022	0.713LysThr: 0.713 ± 0.023	1.101LysVal: 1.101 ± 0.033	0.14LysTrp: 0.14 ± 0.01	0.226LysTyr: 0.226 ± 0.014	0.0LysXaa: 0.0 ± 0.0
Leu	16.556LeuAla: 16.556 ± 0.153	0.679LeuCys: 0.679 ± 0.027	7.703LeuAsp: 7.703 ± 0.095	6.898LeuGlu: 6.898 ± 0.07	2.435LeuPhe: 2.435 ± 0.055	10.027LeuGly: 10.027 ± 0.088	2.228LeuHis: 2.228 ± 0.042	2.892LeuIle: 2.892 ± 0.059	1.058LeuLys: 1.058 ± 0.033	11.012LeuLeu: 11.012 ± 0.137	1.358LeuMet: 1.358 ± 0.033	1.308LeuAsn: 1.308 ± 0.032	5.705LeuPro: 5.705 ± 0.07	2.38LeuGln: 2.38 ± 0.041	8.354LeuArg: 8.354 ± 0.084	4.58LeuSer: 4.58 ± 0.055	5.506LeuThr: 5.506 ± 0.065	9.867LeuVal: 9.867 ± 0.106	1.182LeuTrp: 1.182 ± 0.03	1.455LeuTyr: 1.455 ± 0.031	0.0LeuXaa: 0.0 ± 0.0
Met	2.049MetAla: 2.049 ± 0.042	0.091MetCys: 0.091 ± 0.008	0.804MetAsp: 0.804 ± 0.026	0.711MetGlu: 0.711 ± 0.023	0.424MetPhe: 0.424 ± 0.019	1.377MetGly: 1.377 ± 0.03	0.335MetHis: 0.335 ± 0.016	0.579MetIle: 0.579 ± 0.024	0.243MetLys: 0.243 ± 0.014	1.648MetLeu: 1.648 ± 0.042	0.273MetMet: 0.273 ± 0.014	0.315MetAsn: 0.315 ± 0.017	0.967MetPro: 0.967 ± 0.028	0.44MetGln: 0.44 ± 0.019	1.456MetArg: 1.456 ± 0.033	1.225MetSer: 1.225 ± 0.028	1.225MetThr: 1.225 ± 0.028	1.29MetVal: 1.29 ± 0.034	0.155MetTrp: 0.155 ± 0.011	0.226MetTyr: 0.226 ± 0.012	0.0MetXaa: 0.0 ± 0.0
Asn	1.872AsnAla: 1.872 ± 0.036	0.124AsnCys: 0.124 ± 0.01	0.881AsnAsp: 0.881 ± 0.025	0.874AsnGlu: 0.874 ± 0.03	0.394AsnPhe: 0.394 ± 0.019	1.302AsnGly: 1.302 ± 0.043	0.372AsnHis: 0.372 ± 0.017	0.465AsnIle: 0.465 ± 0.02	0.177AsnLys: 0.177 ± 0.012	1.578AsnLeu: 1.578 ± 0.038	0.234AsnMet: 0.234 ± 0.013	0.279AsnAsn: 0.279 ± 0.019	1.213AsnPro: 1.213 ± 0.027	0.399AsnGln: 0.399 ± 0.018	1.155AsnArg: 1.155 ± 0.026	0.514AsnSer: 0.514 ± 0.024	0.704AsnThr: 0.704 ± 0.022	1.337AsnVal: 1.337 ± 0.031	0.21AsnTrp: 0.21 ± 0.013	0.312AsnTyr: 0.312 ± 0.013	0.0AsnXaa: 0.0 ± 0.0
Pro	7.425ProAla: 7.425 ± 0.083	0.333ProCys: 0.333 ± 0.016	5.464ProAsp: 5.464 ± 0.08	4.967ProGlu: 4.967 ± 0.068	1.543ProPhe: 1.543 ± 0.032	6.082ProGly: 6.082 ± 0.078	1.435ProHis: 1.435 ± 0.035	1.744ProIle: 1.744 ± 0.036	0.617ProLys: 0.617 ± 0.023	5.144ProLeu: 5.144 ± 0.058	0.971ProMet: 0.971 ± 0.024	0.897ProAsn: 0.897 ± 0.029	4.012ProPro: 4.012 ± 0.07	1.55ProGln: 1.55 ± 0.034	4.438ProArg: 4.438 ± 0.074	3.186ProSer: 3.186 ± 0.05	3.451ProThr: 3.451 ± 0.048	4.919ProVal: 4.919 ± 0.063	0.893ProTrp: 0.893 ± 0.029	0.927ProTyr: 0.927 ± 0.028	0.0ProXaa: 0.0 ± 0.0
Gln	3.64GlnAla: 3.64 ± 0.059	0.147GlnCys: 0.147 ± 0.011	1.291GlnAsp: 1.291 ± 0.037	1.594GlnGlu: 1.594 ± 0.044	0.598GlnPhe: 0.598 ± 0.023	2.172GlnGly: 2.172 ± 0.047	0.71GlnHis: 0.71 ± 0.023	0.907GlnIle: 0.907 ± 0.028	0.31GlnLys: 0.31 ± 0.015	3.267GlnLeu: 3.267 ± 0.056	0.469GlnMet: 0.469 ± 0.018	0.344GlnAsn: 0.344 ± 0.017	1.792GlnPro: 1.792 ± 0.04	1.138GlnGln: 1.138 ± 0.037	3.119GlnArg: 3.119 ± 0.057	1.051GlnSer: 1.051 ± 0.033	1.23GlnThr: 1.23 ± 0.028	2.305GlnVal: 2.305 ± 0.042	0.425GlnTrp: 0.425 ± 0.017	0.436GlnTyr: 0.436 ± 0.02	0.0GlnXaa: 0.0 ± 0.0
Arg	10.887ArgAla: 10.887 ± 0.109	0.727ArgCys: 0.727 ± 0.024	5.442ArgAsp: 5.442 ± 0.067	5.954ArgGlu: 5.954 ± 0.073	2.474ArgPhe: 2.474 ± 0.042	6.908ArgGly: 6.908 ± 0.086	2.194ArgHis: 2.194 ± 0.047	3.098ArgIle: 3.098 ± 0.046	1.048ArgLys: 1.048 ± 0.025	9.32ArgLeu: 9.32 ± 0.117	1.614ArgMet: 1.614 ± 0.034	1.15ArgAsn: 1.15 ± 0.031	4.768ArgPro: 4.768 ± 0.059	2.345ArgGln: 2.345 ± 0.046	8.62ArgArg: 8.62 ± 0.123	4.136ArgSer: 4.136 ± 0.061	4.469ArgThr: 4.469 ± 0.06	7.159ArgVal: 7.159 ± 0.075	1.567ArgTrp: 1.567 ± 0.037	1.715ArgTyr: 1.715 ± 0.039	0.0ArgXaa: 0.0 ± 0.0
Ser	5.763SerAla: 5.763 ± 0.071	0.355SerCys: 0.355 ± 0.016	3.011SerAsp: 3.011 ± 0.057	2.948SerGlu: 2.948 ± 0.05	1.275SerPhe: 1.275 ± 0.033	5.099SerGly: 5.099 ± 0.069	0.962SerHis: 0.962 ± 0.03	1.477SerIle: 1.477 ± 0.036	0.605SerLys: 0.605 ± 0.025	4.194SerLeu: 4.194 ± 0.059	0.891SerMet: 0.891 ± 0.025	0.746SerAsn: 0.746 ± 0.026	2.996SerPro: 2.996 ± 0.047	1.191SerGln: 1.191 ± 0.034	3.737SerArg: 3.737 ± 0.064	2.596SerSer: 2.596 ± 0.053	2.692SerThr: 2.692 ± 0.048	3.78SerVal: 3.78 ± 0.06	0.759SerTrp: 0.759 ± 0.025	0.792SerTyr: 0.792 ± 0.026	0.0SerXaa: 0.0 ± 0.0
Thr	7.15ThrAla: 7.15 ± 0.083	0.361ThrCys: 0.361 ± 0.019	3.414ThrAsp: 3.414 ± 0.061	3.212ThrGlu: 3.212 ± 0.053	1.588ThrPhe: 1.588 ± 0.035	5.573ThrGly: 5.573 ± 0.066	1.209ThrHis: 1.209 ± 0.033	1.971ThrIle: 1.971 ± 0.044	0.66ThrLys: 0.66 ± 0.024	5.297ThrLeu: 5.297 ± 0.066	0.903ThrMet: 0.903 ± 0.023	0.883ThrAsn: 0.883 ± 0.025	3.364ThrPro: 3.364 ± 0.052	1.204ThrGln: 1.204 ± 0.034	4.072ThrArg: 4.072 ± 0.054	2.837ThrSer: 2.837 ± 0.043	3.242ThrThr: 3.242 ± 0.054	5.215ThrVal: 5.215 ± 0.077	0.739ThrTrp: 0.739 ± 0.024	1.038ThrTyr: 1.038 ± 0.03	0.0ThrXaa: 0.0 ± 0.0
Val	12.938ValAla: 12.938 ± 0.128	0.692ValCys: 0.692 ± 0.025	6.48ValAsp: 6.48 ± 0.082	6.372ValGlu: 6.372 ± 0.091	2.183ValPhe: 2.183 ± 0.05	8.091ValGly: 8.091 ± 0.097	1.971ValHis: 1.971 ± 0.04	2.769ValIle: 2.769 ± 0.048	0.94ValLys: 0.94 ± 0.027	9.492ValLeu: 9.492 ± 0.102	1.213ValMet: 1.213 ± 0.034	1.344ValAsn: 1.344 ± 0.036	4.933ValPro: 4.933 ± 0.065	2.065ValGln: 2.065 ± 0.035	6.963ValArg: 6.963 ± 0.092	3.95ValSer: 3.95 ± 0.052	5.218ValThr: 5.218 ± 0.077	8.835ValVal: 8.835 ± 0.101	1.1ValTrp: 1.1 ± 0.032	1.332ValTyr: 1.332 ± 0.035	0.0ValXaa: 0.0 ± 0.0
Trp	1.511TrpAla: 1.511 ± 0.035	0.157TrpCys: 0.157 ± 0.012	0.787TrpAsp: 0.787 ± 0.028	0.839TrpGlu: 0.839 ± 0.026	0.494TrpPhe: 0.494 ± 0.02	1.044TrpGly: 1.044 ± 0.031	0.409TrpHis: 0.409 ± 0.018	0.511TrpIle: 0.511 ± 0.018	0.174TrpLys: 0.174 ± 0.011	1.816TrpLeu: 1.816 ± 0.038	0.254TrpMet: 0.254 ± 0.015	0.28TrpAsn: 0.28 ± 0.013	0.846TrpPro: 0.846 ± 0.026	0.577TrpGln: 0.577 ± 0.02	1.395TrpArg: 1.395 ± 0.034	0.791TrpSer: 0.791 ± 0.027	0.793TrpThr: 0.793 ± 0.027	1.119TrpVal: 1.119 ± 0.03	0.351TrpTrp: 0.351 ± 0.016	0.243TrpTyr: 0.243 ± 0.013	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.138TyrAla: 2.138 ± 0.037	0.155TyrCys: 0.155 ± 0.01	1.179TyrAsp: 1.179 ± 0.034	1.339TyrGlu: 1.339 ± 0.039	0.479TyrPhe: 0.479 ± 0.021	1.661TyrGly: 1.661 ± 0.036	0.416TyrHis: 0.416 ± 0.017	0.414TyrIle: 0.414 ± 0.019	0.211TyrLys: 0.211 ± 0.013	1.821TyrLeu: 1.821 ± 0.039	0.18TyrMet: 0.18 ± 0.012	0.269TyrAsn: 0.269 ± 0.015	0.981TyrPro: 0.981 ± 0.029	0.517TyrGln: 0.517 ± 0.022	1.623TyrArg: 1.623 ± 0.036	0.62TyrSer: 0.62 ± 0.023	0.841TyrThr: 0.841 ± 0.026	1.386TyrVal: 1.386 ± 0.033	0.269TyrTrp: 0.269 ± 0.015	0.339TyrTyr: 0.339 ± 0.018	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4050 proteins (1347321 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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