Amino acid dipepetide frequency for Candidatus Aquarickettsia rohweri

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.268AlaAla: 3.268 ± 0.131
0.623AlaCys: 0.623 ± 0.043
2.423AlaAsp: 2.423 ± 0.091
2.827AlaGlu: 2.827 ± 0.089
2.314AlaPhe: 2.314 ± 0.096
2.844AlaGly: 2.844 ± 0.102
0.819AlaHis: 0.819 ± 0.049
5.61AlaIle: 5.61 ± 0.13
5.408AlaLys: 5.408 ± 0.145
5.035AlaLeu: 5.035 ± 0.119
1.077AlaMet: 1.077 ± 0.055
3.273AlaAsn: 3.273 ± 0.094
1.229AlaPro: 1.229 ± 0.061
1.546AlaGln: 1.546 ± 0.076
1.689AlaArg: 1.689 ± 0.066
3.433AlaSer: 3.433 ± 0.103
2.331AlaThr: 2.331 ± 0.075
2.962AlaVal: 2.962 ± 0.119
0.362AlaTrp: 0.362 ± 0.034
1.829AlaTyr: 1.829 ± 0.076
0.0AlaXaa: 0.0 ± 0.0
Cys
0.541CysAla: 0.541 ± 0.044
0.126CysCys: 0.126 ± 0.019
0.586CysAsp: 0.586 ± 0.042
0.659CysGlu: 0.659 ± 0.049
0.564CysPhe: 0.564 ± 0.043
0.665CysGly: 0.665 ± 0.047
0.278CysHis: 0.278 ± 0.028
1.201CysIle: 1.201 ± 0.069
1.164CysLys: 1.164 ± 0.065
0.923CysLeu: 0.923 ± 0.05
0.269CysMet: 0.269 ± 0.029
0.783CysAsn: 0.783 ± 0.045
0.41CysPro: 0.41 ± 0.038
0.275CysGln: 0.275 ± 0.028
0.317CysArg: 0.317 ± 0.03
0.87CysSer: 0.87 ± 0.052
0.561CysThr: 0.561 ± 0.043
0.583CysVal: 0.583 ± 0.043
0.095CysTrp: 0.095 ± 0.016
0.452CysTyr: 0.452 ± 0.037
0.0CysXaa: 0.0 ± 0.0
Asp
2.331AspAla: 2.331 ± 0.081
0.614AspCys: 0.614 ± 0.043
2.665AspAsp: 2.665 ± 0.1
3.613AspGlu: 3.613 ± 0.111
3.035AspPhe: 3.035 ± 0.104
2.429AspGly: 2.429 ± 0.088
0.892AspHis: 0.892 ± 0.051
6.003AspIle: 6.003 ± 0.149
5.658AspLys: 5.658 ± 0.127
5.012AspLeu: 5.012 ± 0.142
0.954AspMet: 0.954 ± 0.052
4.137AspAsn: 4.137 ± 0.123
1.245AspPro: 1.245 ± 0.062
1.604AspGln: 1.604 ± 0.07
1.484AspArg: 1.484 ± 0.065
3.632AspSer: 3.632 ± 0.112
2.207AspThr: 2.207 ± 0.078
2.693AspVal: 2.693 ± 0.087
0.48AspTrp: 0.48 ± 0.035
2.62AspTyr: 2.62 ± 0.089
0.0AspXaa: 0.0 ± 0.0
Glu
3.035GluAla: 3.035 ± 0.115
0.631GluCys: 0.631 ± 0.045
2.836GluAsp: 2.836 ± 0.102
4.552GluGlu: 4.552 ± 0.13
2.808GluPhe: 2.808 ± 0.095
2.659GluGly: 2.659 ± 0.086
0.889GluHis: 0.889 ± 0.046
6.892GluIle: 6.892 ± 0.15
6.805GluLys: 6.805 ± 0.147
6.053GluLeu: 6.053 ± 0.134
1.313GluMet: 1.313 ± 0.059
4.457GluAsn: 4.457 ± 0.121
1.08GluPro: 1.08 ± 0.055
1.916GluGln: 1.916 ± 0.079
1.896GluArg: 1.896 ± 0.079
3.531GluSer: 3.531 ± 0.084
2.165GluThr: 2.165 ± 0.089
3.747GluVal: 3.747 ± 0.112
0.412GluTrp: 0.412 ± 0.04
2.628GluTyr: 2.628 ± 0.094
0.0GluXaa: 0.0 ± 0.0
Phe
2.696PheAla: 2.696 ± 0.09
0.712PheCys: 0.712 ± 0.05
3.013PheAsp: 3.013 ± 0.092
2.726PheGlu: 2.726 ± 0.098
3.06PhePhe: 3.06 ± 0.127
2.872PheGly: 2.872 ± 0.097
0.827PheHis: 0.827 ± 0.05
5.691PheIle: 5.691 ± 0.161
4.432PheLys: 4.432 ± 0.106
5.071PheLeu: 5.071 ± 0.139
0.912PheMet: 0.912 ± 0.056
3.89PheAsn: 3.89 ± 0.098
1.293PhePro: 1.293 ± 0.058
1.388PheGln: 1.388 ± 0.065
1.296PheArg: 1.296 ± 0.067
4.23PheSer: 4.23 ± 0.122
2.387PheThr: 2.387 ± 0.086
2.278PheVal: 2.278 ± 0.083
0.457PheTrp: 0.457 ± 0.037
2.129PheTyr: 2.129 ± 0.087
0.0PheXaa: 0.0 ± 0.0
Gly
3.142GlyAla: 3.142 ± 0.138
0.687GlyCys: 0.687 ± 0.043
2.822GlyAsp: 2.822 ± 0.088
3.057GlyGlu: 3.057 ± 0.098
2.785GlyPhe: 2.785 ± 0.096
3.363GlyGly: 3.363 ± 0.128
0.945GlyHis: 0.945 ± 0.05
5.907GlyIle: 5.907 ± 0.139
4.914GlyLys: 4.914 ± 0.137
4.662GlyLeu: 4.662 ± 0.122
1.307GlyMet: 1.307 ± 0.061
2.903GlyAsn: 2.903 ± 0.097
1.015GlyPro: 1.015 ± 0.05
1.344GlyGln: 1.344 ± 0.066
1.725GlyArg: 1.725 ± 0.082
3.321GlySer: 3.321 ± 0.1
2.384GlyThr: 2.384 ± 0.089
3.526GlyVal: 3.526 ± 0.094
0.485GlyTrp: 0.485 ± 0.04
2.51GlyTyr: 2.51 ± 0.088
0.0GlyXaa: 0.0 ± 0.0
His
0.752HisAla: 0.752 ± 0.047
0.261HisCys: 0.261 ± 0.025
0.878HisAsp: 0.878 ± 0.054
0.934HisGlu: 0.934 ± 0.052
0.928HisPhe: 0.928 ± 0.045
0.973HisGly: 0.973 ± 0.056
0.351HisHis: 0.351 ± 0.032
1.641HisIle: 1.641 ± 0.071
1.475HisLys: 1.475 ± 0.066
1.579HisLeu: 1.579 ± 0.063
0.342HisMet: 0.342 ± 0.027
1.344HisAsn: 1.344 ± 0.063
0.611HisPro: 0.611 ± 0.045
0.555HisGln: 0.555 ± 0.043
0.544HisArg: 0.544 ± 0.043
1.192HisSer: 1.192 ± 0.056
0.701HisThr: 0.701 ± 0.045
0.743HisVal: 0.743 ± 0.043
0.126HisTrp: 0.126 ± 0.018
0.822HisTyr: 0.822 ± 0.05
0.0HisXaa: 0.0 ± 0.0
Ile
6.221IleAla: 6.221 ± 0.154
1.4IleCys: 1.4 ± 0.061
6.468IleAsp: 6.468 ± 0.141
6.471IleGlu: 6.471 ± 0.131
5.601IlePhe: 5.601 ± 0.156
6.23IleGly: 6.23 ± 0.178
1.618IleHis: 1.618 ± 0.069
11.618IleIle: 11.618 ± 0.271
10.465IleLys: 10.465 ± 0.19
10.087IleLeu: 10.087 ± 0.226
2.031IleMet: 2.031 ± 0.086
8.3IleAsn: 8.3 ± 0.173
3.602IlePro: 3.602 ± 0.11
2.466IleGln: 2.466 ± 0.08
2.889IleArg: 2.889 ± 0.085
8.923IleSer: 8.923 ± 0.174
5.102IleThr: 5.102 ± 0.119
5.032IleVal: 5.032 ± 0.115
0.726IleTrp: 0.726 ± 0.046
3.837IleTyr: 3.837 ± 0.104
0.0IleXaa: 0.0 ± 0.0
Lys
4.421LysAla: 4.421 ± 0.113
0.917LysCys: 0.917 ± 0.054
5.531LysAsp: 5.531 ± 0.132
6.74LysGlu: 6.74 ± 0.177
5.049LysPhe: 5.049 ± 0.136
4.16LysGly: 4.16 ± 0.124
1.652LysHis: 1.652 ± 0.07
11.64LysIle: 11.64 ± 0.192
10.019LysLys: 10.019 ± 0.195
9.657LysLeu: 9.657 ± 0.18
1.941LysMet: 1.941 ± 0.077
8.962LysAsn: 8.962 ± 0.167
2.227LysPro: 2.227 ± 0.078
3.069LysGln: 3.069 ± 0.099
2.701LysArg: 2.701 ± 0.091
6.729LysSer: 6.729 ± 0.128
4.095LysThr: 4.095 ± 0.107
5.545LysVal: 5.545 ± 0.15
0.679LysTrp: 0.679 ± 0.05
4.468LysTyr: 4.468 ± 0.121
0.0LysXaa: 0.0 ± 0.0
Leu
5.15LeuAla: 5.15 ± 0.12
1.074LeuCys: 1.074 ± 0.053
5.198LeuAsp: 5.198 ± 0.15
5.778LeuGlu: 5.778 ± 0.133
4.693LeuPhe: 4.693 ± 0.148
5.214LeuGly: 5.214 ± 0.121
1.495LeuHis: 1.495 ± 0.066
9.411LeuIle: 9.411 ± 0.222
9.921LeuLys: 9.921 ± 0.195
9.469LeuLeu: 9.469 ± 0.228
1.809LeuMet: 1.809 ± 0.073
7.032LeuAsn: 7.032 ± 0.162
3.085LeuPro: 3.085 ± 0.096
2.883LeuGln: 2.883 ± 0.105
2.987LeuArg: 2.987 ± 0.106
7.666LeuSer: 7.666 ± 0.162
4.463LeuThr: 4.463 ± 0.132
4.833LeuVal: 4.833 ± 0.116
0.67LeuTrp: 0.67 ± 0.041
3.458LeuTyr: 3.458 ± 0.118
0.0LeuXaa: 0.0 ± 0.0
Met
1.074MetAla: 1.074 ± 0.054
0.191MetCys: 0.191 ± 0.022
0.942MetAsp: 0.942 ± 0.051
0.962MetGlu: 0.962 ± 0.059
0.833MetPhe: 0.833 ± 0.051
1.088MetGly: 1.088 ± 0.054
0.438MetHis: 0.438 ± 0.032
1.913MetIle: 1.913 ± 0.076
1.778MetLys: 1.778 ± 0.071
2.25MetLeu: 2.25 ± 0.088
0.491MetMet: 0.491 ± 0.039
1.24MetAsn: 1.24 ± 0.063
0.875MetPro: 0.875 ± 0.054
0.895MetGln: 0.895 ± 0.053
0.614MetArg: 0.614 ± 0.04
1.652MetSer: 1.652 ± 0.065
0.847MetThr: 0.847 ± 0.051
1.057MetVal: 1.057 ± 0.057
0.137MetTrp: 0.137 ± 0.02
0.592MetTyr: 0.592 ± 0.043
0.0MetXaa: 0.0 ± 0.0
Asn
2.813AsnAla: 2.813 ± 0.091
0.825AsnCys: 0.825 ± 0.048
3.618AsnAsp: 3.618 ± 0.113
3.916AsnGlu: 3.916 ± 0.104
4.205AsnPhe: 4.205 ± 0.114
2.878AsnGly: 2.878 ± 0.094
1.344AsnHis: 1.344 ± 0.06
8.67AsnIle: 8.67 ± 0.158
8.333AsnLys: 8.333 ± 0.16
7.801AsnLeu: 7.801 ± 0.176
1.431AsnMet: 1.431 ± 0.061
6.614AsnAsn: 6.614 ± 0.178
2.264AsnPro: 2.264 ± 0.081
2.519AsnGln: 2.519 ± 0.099
1.725AsnArg: 1.725 ± 0.071
5.47AsnSer: 5.47 ± 0.15
3.268AsnThr: 3.268 ± 0.112
3.122AsnVal: 3.122 ± 0.096
0.569AsnTrp: 0.569 ± 0.043
3.422AsnTyr: 3.422 ± 0.112
0.0AsnXaa: 0.0 ± 0.0
Pro
1.203ProAla: 1.203 ± 0.07
0.297ProCys: 0.297 ± 0.032
1.411ProAsp: 1.411 ± 0.073
1.871ProGlu: 1.871 ± 0.072
1.377ProPhe: 1.377 ± 0.061
1.624ProGly: 1.624 ± 0.059
0.527ProHis: 0.527 ± 0.037
3.136ProIle: 3.136 ± 0.085
2.729ProLys: 2.729 ± 0.082
2.522ProLeu: 2.522 ± 0.083
0.553ProMet: 0.553 ± 0.042
1.902ProAsn: 1.902 ± 0.079
0.724ProPro: 0.724 ± 0.055
0.847ProGln: 0.847 ± 0.055
0.738ProArg: 0.738 ± 0.046
1.719ProSer: 1.719 ± 0.064
1.285ProThr: 1.285 ± 0.063
1.523ProVal: 1.523 ± 0.071
0.219ProTrp: 0.219 ± 0.027
1.36ProTyr: 1.36 ± 0.063
0.0ProXaa: 0.0 ± 0.0
Gln
1.523GlnAla: 1.523 ± 0.075
0.283GlnCys: 0.283 ± 0.029
1.801GlnAsp: 1.801 ± 0.065
2.042GlnGlu: 2.042 ± 0.09
1.234GlnPhe: 1.234 ± 0.065
1.495GlnGly: 1.495 ± 0.072
0.485GlnHis: 0.485 ± 0.038
3.178GlnIle: 3.178 ± 0.101
3.136GlnLys: 3.136 ± 0.097
2.679GlnLeu: 2.679 ± 0.091
0.64GlnMet: 0.64 ± 0.044
2.667GlnAsn: 2.667 ± 0.094
0.662GlnPro: 0.662 ± 0.039
1.102GlnGln: 1.102 ± 0.068
0.996GlnArg: 0.996 ± 0.048
1.927GlnSer: 1.927 ± 0.069
1.133GlnThr: 1.133 ± 0.061
1.546GlnVal: 1.546 ± 0.073
0.177GlnTrp: 0.177 ± 0.022
1.198GlnTyr: 1.198 ± 0.059
0.0GlnXaa: 0.0 ± 0.0
Arg
1.531ArgAla: 1.531 ± 0.078
0.314ArgCys: 0.314 ± 0.033
1.613ArgAsp: 1.613 ± 0.074
1.84ArgGlu: 1.84 ± 0.078
1.416ArgPhe: 1.416 ± 0.062
1.649ArgGly: 1.649 ± 0.067
0.494ArgHis: 0.494 ± 0.035
2.937ArgIle: 2.937 ± 0.102
2.696ArgLys: 2.696 ± 0.089
2.763ArgLeu: 2.763 ± 0.09
0.67ArgMet: 0.67 ± 0.047
1.784ArgAsn: 1.784 ± 0.068
0.816ArgPro: 0.816 ± 0.046
0.864ArgGln: 0.864 ± 0.051
0.987ArgArg: 0.987 ± 0.059
1.739ArgSer: 1.739 ± 0.067
1.206ArgThr: 1.206 ± 0.053
1.742ArgVal: 1.742 ± 0.071
0.255ArgTrp: 0.255 ± 0.027
1.271ArgTyr: 1.271 ± 0.059
0.0ArgXaa: 0.0 ± 0.0
Ser
3.54SerAla: 3.54 ± 0.124
0.729SerCys: 0.729 ± 0.054
3.604SerAsp: 3.604 ± 0.112
4.185SerGlu: 4.185 ± 0.128
3.703SerPhe: 3.703 ± 0.113
4.311SerGly: 4.311 ± 0.124
1.139SerHis: 1.139 ± 0.06
8.002SerIle: 8.002 ± 0.152
7.335SerLys: 7.335 ± 0.146
6.785SerLeu: 6.785 ± 0.155
1.47SerMet: 1.47 ± 0.064
5.304SerAsn: 5.304 ± 0.13
1.798SerPro: 1.798 ± 0.072
2.179SerGln: 2.179 ± 0.076
1.986SerArg: 1.986 ± 0.084
5.22SerSer: 5.22 ± 0.147
3.475SerThr: 3.475 ± 0.107
3.66SerVal: 3.66 ± 0.08
0.6SerTrp: 0.6 ± 0.041
2.903SerTyr: 2.903 ± 0.109
0.0SerXaa: 0.0 ± 0.0
Thr
2.379ThrAla: 2.379 ± 0.08
0.502ThrCys: 0.502 ± 0.038
2.171ThrAsp: 2.171 ± 0.084
2.348ThrGlu: 2.348 ± 0.092
2.213ThrPhe: 2.213 ± 0.09
2.665ThrGly: 2.665 ± 0.085
0.884ThrHis: 0.884 ± 0.051
4.715ThrIle: 4.715 ± 0.139
4.154ThrLys: 4.154 ± 0.119
4.407ThrLeu: 4.407 ± 0.112
0.67ThrMet: 0.67 ± 0.044
3.06ThrAsn: 3.06 ± 0.109
1.75ThrPro: 1.75 ± 0.079
1.467ThrGln: 1.467 ± 0.063
1.15ThrArg: 1.15 ± 0.052
3.321ThrSer: 3.321 ± 0.095
2.367ThrThr: 2.367 ± 0.09
2.322ThrVal: 2.322 ± 0.087
0.295ThrTrp: 0.295 ± 0.027
1.588ThrTyr: 1.588 ± 0.07
0.0ThrXaa: 0.0 ± 0.0
Val
2.861ValAla: 2.861 ± 0.1
0.575ValCys: 0.575 ± 0.039
3.021ValAsp: 3.021 ± 0.088
3.287ValGlu: 3.287 ± 0.105
2.558ValPhe: 2.558 ± 0.09
3.13ValGly: 3.13 ± 0.101
0.76ValHis: 0.76 ± 0.047
5.958ValIle: 5.958 ± 0.145
5.105ValLys: 5.105 ± 0.138
4.533ValLeu: 4.533 ± 0.124
1.111ValMet: 1.111 ± 0.063
3.649ValAsn: 3.649 ± 0.095
1.531ValPro: 1.531 ± 0.067
1.316ValGln: 1.316 ± 0.06
1.383ValArg: 1.383 ± 0.072
3.638ValSer: 3.638 ± 0.099
2.418ValThr: 2.418 ± 0.09
2.954ValVal: 2.954 ± 0.109
0.325ValTrp: 0.325 ± 0.033
1.896ValTyr: 1.896 ± 0.08
0.0ValXaa: 0.0 ± 0.0
Trp
0.37TrpAla: 0.37 ± 0.04
0.095TrpCys: 0.095 ± 0.018
0.37TrpAsp: 0.37 ± 0.033
0.348TrpGlu: 0.348 ± 0.031
0.39TrpPhe: 0.39 ± 0.031
0.449TrpGly: 0.449 ± 0.038
0.219TrpHis: 0.219 ± 0.027
0.704TrpIle: 0.704 ± 0.05
0.69TrpLys: 0.69 ± 0.047
0.83TrpLeu: 0.83 ± 0.049
0.121TrpMet: 0.121 ± 0.019
0.482TrpAsn: 0.482 ± 0.039
0.194TrpPro: 0.194 ± 0.024
0.339TrpGln: 0.339 ± 0.034
0.314TrpArg: 0.314 ± 0.031
0.508TrpSer: 0.508 ± 0.037
0.247TrpThr: 0.247 ± 0.026
0.407TrpVal: 0.407 ± 0.033
0.087TrpTrp: 0.087 ± 0.015
0.297TrpTyr: 0.297 ± 0.033
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.05TyrAla: 2.05 ± 0.079
0.463TyrCys: 0.463 ± 0.041
2.337TyrAsp: 2.337 ± 0.084
2.149TyrGlu: 2.149 ± 0.074
2.595TyrPhe: 2.595 ± 0.094
2.107TyrGly: 2.107 ± 0.089
0.698TyrHis: 0.698 ± 0.043
4.261TyrIle: 4.261 ± 0.098
3.989TyrLys: 3.989 ± 0.111
4.174TyrLeu: 4.174 ± 0.118
0.757TyrMet: 0.757 ± 0.042
3.021TyrAsn: 3.021 ± 0.096
1.156TyrPro: 1.156 ± 0.062
1.33TyrGln: 1.33 ± 0.065
1.167TyrArg: 1.167 ± 0.059
3.209TyrSer: 3.209 ± 0.106
1.784TyrThr: 1.784 ± 0.079
1.733TyrVal: 1.733 ± 0.081
0.303TyrTrp: 0.303 ± 0.031
1.82TyrTyr: 1.82 ± 0.075
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1222 proteins (356515 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski