Amino acid dipepetide frequency for Streptomyces shenzhenensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
21.947AlaAla: 21.947 ± 0.15
1.035AlaCys: 1.035 ± 0.021
8.668AlaAsp: 8.668 ± 0.064
8.66AlaGlu: 8.66 ± 0.078
3.486AlaPhe: 3.486 ± 0.032
13.441AlaGly: 13.441 ± 0.093
2.972AlaHis: 2.972 ± 0.036
3.424AlaIle: 3.424 ± 0.038
2.619AlaLys: 2.619 ± 0.041
14.618AlaLeu: 14.618 ± 0.105
2.44AlaMet: 2.44 ± 0.032
1.897AlaAsn: 1.897 ± 0.03
7.199AlaPro: 7.199 ± 0.064
3.913AlaGln: 3.913 ± 0.04
10.653AlaArg: 10.653 ± 0.072
5.729AlaSer: 5.729 ± 0.053
7.126AlaThr: 7.126 ± 0.049
12.654AlaVal: 12.654 ± 0.084
1.856AlaTrp: 1.856 ± 0.026
2.745AlaTyr: 2.745 ± 0.032
0.0AlaXaa: 0.0 ± 0.0
Cys
1.112CysAla: 1.112 ± 0.023
0.106CysCys: 0.106 ± 0.007
0.441CysAsp: 0.441 ± 0.014
0.371CysGlu: 0.371 ± 0.014
0.235CysPhe: 0.235 ± 0.01
0.946CysGly: 0.946 ± 0.02
0.186CysHis: 0.186 ± 0.007
0.179CysIle: 0.179 ± 0.009
0.095CysLys: 0.095 ± 0.006
0.728CysLeu: 0.728 ± 0.019
0.11CysMet: 0.11 ± 0.006
0.129CysAsn: 0.129 ± 0.007
0.505CysPro: 0.505 ± 0.015
0.178CysGln: 0.178 ± 0.008
0.616CysArg: 0.616 ± 0.015
0.431CysSer: 0.431 ± 0.012
0.51CysThr: 0.51 ± 0.015
0.661CysVal: 0.661 ± 0.016
0.128CysTrp: 0.128 ± 0.007
0.146CysTyr: 0.146 ± 0.007
0.0CysXaa: 0.0 ± 0.0
Asp
7.638AspAla: 7.638 ± 0.046
0.403AspCys: 0.403 ± 0.013
3.523AspAsp: 3.523 ± 0.037
3.664AspGlu: 3.664 ± 0.039
1.621AspPhe: 1.621 ± 0.024
6.514AspGly: 6.514 ± 0.054
1.442AspHis: 1.442 ± 0.026
1.955AspIle: 1.955 ± 0.026
1.126AspLys: 1.126 ± 0.022
6.265AspLeu: 6.265 ± 0.057
0.787AspMet: 0.787 ± 0.018
0.968AspAsn: 0.968 ± 0.019
4.498AspPro: 4.498 ± 0.046
1.536AspGln: 1.536 ± 0.024
5.097AspArg: 5.097 ± 0.046
2.546AspSer: 2.546 ± 0.032
3.423AspThr: 3.423 ± 0.036
4.773AspVal: 4.773 ± 0.045
1.019AspTrp: 1.019 ± 0.02
1.133AspTyr: 1.133 ± 0.02
0.0AspXaa: 0.0 ± 0.0
Glu
6.839GluAla: 6.839 ± 0.065
0.34GluCys: 0.34 ± 0.01
2.577GluAsp: 2.577 ± 0.033
3.241GluGlu: 3.241 ± 0.041
1.452GluPhe: 1.452 ± 0.026
3.919GluGly: 3.919 ± 0.045
1.55GluHis: 1.55 ± 0.026
2.224GluIle: 2.224 ± 0.034
1.277GluLys: 1.277 ± 0.024
6.532GluLeu: 6.532 ± 0.057
0.825GluMet: 0.825 ± 0.014
0.994GluAsn: 0.994 ± 0.019
3.375GluPro: 3.375 ± 0.036
2.196GluGln: 2.196 ± 0.033
5.412GluArg: 5.412 ± 0.052
2.464GluSer: 2.464 ± 0.038
2.853GluThr: 2.853 ± 0.033
4.23GluVal: 4.23 ± 0.042
0.721GluTrp: 0.721 ± 0.016
1.086GluTyr: 1.086 ± 0.019
0.0GluXaa: 0.0 ± 0.0
Phe
3.679PheAla: 3.679 ± 0.042
0.253PheCys: 0.253 ± 0.01
1.985PheAsp: 1.985 ± 0.029
1.399PheGlu: 1.399 ± 0.019
0.854PhePhe: 0.854 ± 0.021
3.015PheGly: 3.015 ± 0.029
0.623PheHis: 0.623 ± 0.014
0.719PheIle: 0.719 ± 0.018
0.468PheLys: 0.468 ± 0.014
2.652PheLeu: 2.652 ± 0.033
0.381PheMet: 0.381 ± 0.012
0.546PheAsn: 0.546 ± 0.014
1.419PhePro: 1.419 ± 0.022
0.707PheGln: 0.707 ± 0.017
1.883PheArg: 1.883 ± 0.03
1.449PheSer: 1.449 ± 0.021
2.044PheThr: 2.044 ± 0.03
2.226PheVal: 2.226 ± 0.029
0.424PheTrp: 0.424 ± 0.012
0.576PheTyr: 0.576 ± 0.013
0.0PheXaa: 0.0 ± 0.0
Gly
11.278GlyAla: 11.278 ± 0.098
0.822GlyCys: 0.822 ± 0.019
5.145GlyAsp: 5.145 ± 0.053
4.727GlyGlu: 4.727 ± 0.047
2.934GlyPhe: 2.934 ± 0.036
8.757GlyGly: 8.757 ± 0.087
2.382GlyHis: 2.382 ± 0.031
3.555GlyIle: 3.555 ± 0.038
2.24GlyLys: 2.24 ± 0.035
9.571GlyLeu: 9.571 ± 0.064
1.932GlyMet: 1.932 ± 0.027
1.791GlyAsn: 1.791 ± 0.029
5.396GlyPro: 5.396 ± 0.059
2.699GlyGln: 2.699 ± 0.033
8.049GlyArg: 8.049 ± 0.062
5.435GlySer: 5.435 ± 0.051
6.62GlyThr: 6.62 ± 0.053
7.565GlyVal: 7.565 ± 0.062
1.714GlyTrp: 1.714 ± 0.025
2.312GlyTyr: 2.312 ± 0.03
0.0GlyXaa: 0.0 ± 0.0
His
2.776HisAla: 2.776 ± 0.029
0.219HisCys: 0.219 ± 0.009
1.42HisAsp: 1.42 ± 0.025
1.242HisGlu: 1.242 ± 0.019
0.659HisPhe: 0.659 ± 0.017
2.507HisGly: 2.507 ± 0.033
0.709HisHis: 0.709 ± 0.018
0.723HisIle: 0.723 ± 0.018
0.353HisLys: 0.353 ± 0.012
2.389HisLeu: 2.389 ± 0.03
0.348HisMet: 0.348 ± 0.012
0.378HisAsn: 0.378 ± 0.013
1.814HisPro: 1.814 ± 0.027
0.639HisGln: 0.639 ± 0.015
2.228HisArg: 2.228 ± 0.034
0.994HisSer: 0.994 ± 0.02
1.447HisThr: 1.447 ± 0.027
1.708HisVal: 1.708 ± 0.023
0.382HisTrp: 0.382 ± 0.014
0.489HisTyr: 0.489 ± 0.013
0.0HisXaa: 0.0 ± 0.0
Ile
4.849IleAla: 4.849 ± 0.047
0.284IleCys: 0.284 ± 0.009
2.27IleAsp: 2.27 ± 0.035
1.975IleGlu: 1.975 ± 0.032
0.683IlePhe: 0.683 ± 0.017
3.558IleGly: 3.558 ± 0.037
0.621IleHis: 0.621 ± 0.017
0.855IleIle: 0.855 ± 0.019
0.707IleLys: 0.707 ± 0.017
2.415IleLeu: 2.415 ± 0.026
0.448IleMet: 0.448 ± 0.013
0.703IleAsn: 0.703 ± 0.017
1.803IlePro: 1.803 ± 0.024
0.726IleGln: 0.726 ± 0.016
2.309IleArg: 2.309 ± 0.031
1.666IleSer: 1.666 ± 0.024
2.268IleThr: 2.268 ± 0.034
2.858IleVal: 2.858 ± 0.036
0.356IleTrp: 0.356 ± 0.01
0.511IleTyr: 0.511 ± 0.014
0.0IleXaa: 0.0 ± 0.0
Lys
2.65LysAla: 2.65 ± 0.043
0.108LysCys: 0.108 ± 0.005
1.268LysAsp: 1.268 ± 0.023
1.117LysGlu: 1.117 ± 0.02
0.425LysPhe: 0.425 ± 0.014
1.733LysGly: 1.733 ± 0.026
0.398LysHis: 0.398 ± 0.011
0.829LysIle: 0.829 ± 0.02
0.782LysLys: 0.782 ± 0.021
1.843LysLeu: 1.843 ± 0.026
0.349LysMet: 0.349 ± 0.01
0.519LysAsn: 0.519 ± 0.013
1.217LysPro: 1.217 ± 0.025
0.684LysGln: 0.684 ± 0.019
1.324LysArg: 1.324 ± 0.021
1.092LysSer: 1.092 ± 0.021
1.184LysThr: 1.184 ± 0.025
1.749LysVal: 1.749 ± 0.028
0.253LysTrp: 0.253 ± 0.009
0.436LysTyr: 0.436 ± 0.014
0.0LysXaa: 0.0 ± 0.0
Leu
15.338LeuAla: 15.338 ± 0.106
0.847LeuCys: 0.847 ± 0.017
6.752LeuAsp: 6.752 ± 0.055
4.352LeuGlu: 4.352 ± 0.042
2.598LeuPhe: 2.598 ± 0.031
9.352LeuGly: 9.352 ± 0.075
2.29LeuHis: 2.29 ± 0.028
3.335LeuIle: 3.335 ± 0.037
1.926LeuLys: 1.926 ± 0.029
11.39LeuLeu: 11.39 ± 0.095
1.568LeuMet: 1.568 ± 0.024
1.72LeuAsn: 1.72 ± 0.025
6.45LeuPro: 6.45 ± 0.051
2.164LeuGln: 2.164 ± 0.03
8.778LeuArg: 8.778 ± 0.072
5.335LeuSer: 5.335 ± 0.051
7.113LeuThr: 7.113 ± 0.049
8.927LeuVal: 8.927 ± 0.071
1.301LeuTrp: 1.301 ± 0.024
1.885LeuTyr: 1.885 ± 0.028
0.0LeuXaa: 0.0 ± 0.0
Met
2.171MetAla: 2.171 ± 0.026
0.136MetCys: 0.136 ± 0.006
0.845MetAsp: 0.845 ± 0.016
0.69MetGlu: 0.69 ± 0.016
0.444MetPhe: 0.444 ± 0.013
1.24MetGly: 1.24 ± 0.025
0.35MetHis: 0.35 ± 0.012
0.634MetIle: 0.634 ± 0.016
0.384MetLys: 0.384 ± 0.012
1.6MetLeu: 1.6 ± 0.023
0.266MetMet: 0.266 ± 0.01
0.42MetAsn: 0.42 ± 0.011
1.066MetPro: 1.066 ± 0.018
0.443MetGln: 0.443 ± 0.013
1.384MetArg: 1.384 ± 0.024
1.292MetSer: 1.292 ± 0.022
1.573MetThr: 1.573 ± 0.023
1.252MetVal: 1.252 ± 0.02
0.205MetTrp: 0.205 ± 0.009
0.315MetTyr: 0.315 ± 0.009
0.0MetXaa: 0.0 ± 0.0
Asn
2.206AsnAla: 2.206 ± 0.03
0.154AsnCys: 0.154 ± 0.007
0.97AsnAsp: 0.97 ± 0.021
0.793AsnGlu: 0.793 ± 0.016
0.5AsnPhe: 0.5 ± 0.014
1.915AsnGly: 1.915 ± 0.034
0.418AsnHis: 0.418 ± 0.013
0.629AsnIle: 0.629 ± 0.016
0.38AsnLys: 0.38 ± 0.013
1.646AsnLeu: 1.646 ± 0.022
0.295AsnMet: 0.295 ± 0.011
0.444AsnAsn: 0.444 ± 0.014
1.349AsnPro: 1.349 ± 0.022
0.518AsnGln: 0.518 ± 0.013
1.269AsnArg: 1.269 ± 0.022
0.954AsnSer: 0.954 ± 0.021
1.164AsnThr: 1.164 ± 0.02
1.389AsnVal: 1.389 ± 0.025
0.287AsnTrp: 0.287 ± 0.012
0.392AsnTyr: 0.392 ± 0.013
0.0AsnXaa: 0.0 ± 0.0
Pro
8.985ProAla: 8.985 ± 0.082
0.352ProCys: 0.352 ± 0.011
4.582ProAsp: 4.582 ± 0.044
4.162ProGlu: 4.162 ± 0.046
1.536ProPhe: 1.536 ± 0.025
6.761ProGly: 6.761 ± 0.063
1.46ProHis: 1.46 ± 0.027
1.24ProIle: 1.24 ± 0.02
1.104ProLys: 1.104 ± 0.023
5.408ProLeu: 5.408 ± 0.05
0.963ProMet: 0.963 ± 0.019
0.929ProAsn: 0.929 ± 0.021
3.561ProPro: 3.561 ± 0.057
1.769ProGln: 1.769 ± 0.03
4.186ProArg: 4.186 ± 0.042
3.112ProSer: 3.112 ± 0.038
3.241ProThr: 3.241 ± 0.043
5.586ProVal: 5.586 ± 0.055
0.914ProTrp: 0.914 ± 0.019
1.425ProTyr: 1.425 ± 0.024
0.0ProXaa: 0.0 ± 0.0
Gln
3.694GlnAla: 3.694 ± 0.037
0.18GlnCys: 0.18 ± 0.009
1.48GlnAsp: 1.48 ± 0.021
1.421GlnGlu: 1.421 ± 0.025
0.697GlnPhe: 0.697 ± 0.016
2.354GlnGly: 2.354 ± 0.035
0.693GlnHis: 0.693 ± 0.017
1.115GlnIle: 1.115 ± 0.019
0.571GlnLys: 0.571 ± 0.016
3.077GlnLeu: 3.077 ± 0.033
0.472GlnMet: 0.472 ± 0.012
0.538GlnAsn: 0.538 ± 0.014
1.715GlnPro: 1.715 ± 0.028
1.275GlnGln: 1.275 ± 0.03
2.404GlnArg: 2.404 ± 0.034
1.287GlnSer: 1.287 ± 0.02
1.394GlnThr: 1.394 ± 0.024
2.407GlnVal: 2.407 ± 0.03
0.451GlnTrp: 0.451 ± 0.012
0.607GlnTyr: 0.607 ± 0.015
0.0GlnXaa: 0.0 ± 0.0
Arg
10.328ArgAla: 10.328 ± 0.075
0.607ArgCys: 0.607 ± 0.017
4.338ArgAsp: 4.338 ± 0.04
4.562ArgGlu: 4.562 ± 0.048
2.345ArgPhe: 2.345 ± 0.028
5.985ArgGly: 5.985 ± 0.048
2.279ArgHis: 2.279 ± 0.032
3.384ArgIle: 3.384 ± 0.04
1.509ArgLys: 1.509 ± 0.025
9.027ArgLeu: 9.027 ± 0.07
1.701ArgMet: 1.701 ± 0.022
1.374ArgAsn: 1.374 ± 0.021
5.288ArgPro: 5.288 ± 0.058
2.376ArgGln: 2.376 ± 0.03
8.031ArgArg: 8.031 ± 0.074
4.157ArgSer: 4.157 ± 0.036
5.679ArgThr: 5.679 ± 0.052
6.046ArgVal: 6.046 ± 0.055
1.364ArgTrp: 1.364 ± 0.024
1.78ArgTyr: 1.78 ± 0.026
0.0ArgXaa: 0.0 ± 0.0
Ser
6.827SerAla: 6.827 ± 0.053
0.409SerCys: 0.409 ± 0.013
2.671SerAsp: 2.671 ± 0.031
2.225SerGlu: 2.225 ± 0.03
1.549SerPhe: 1.549 ± 0.023
6.023SerGly: 6.023 ± 0.057
0.987SerHis: 0.987 ± 0.019
1.415SerIle: 1.415 ± 0.025
0.922SerLys: 0.922 ± 0.019
4.885SerLeu: 4.885 ± 0.045
1.031SerMet: 1.031 ± 0.019
0.839SerAsn: 0.839 ± 0.017
3.139SerPro: 3.139 ± 0.041
1.204SerGln: 1.204 ± 0.02
3.707SerArg: 3.707 ± 0.04
2.831SerSer: 2.831 ± 0.037
3.07SerThr: 3.07 ± 0.038
4.364SerVal: 4.364 ± 0.043
0.901SerTrp: 0.901 ± 0.016
1.217SerTyr: 1.217 ± 0.025
0.0SerXaa: 0.0 ± 0.0
Thr
9.38ThrAla: 9.38 ± 0.067
0.432ThrCys: 0.432 ± 0.014
3.763ThrAsp: 3.763 ± 0.041
3.251ThrGlu: 3.251 ± 0.041
1.625ThrPhe: 1.625 ± 0.025
7.027ThrGly: 7.027 ± 0.062
1.262ThrHis: 1.262 ± 0.024
1.671ThrIle: 1.671 ± 0.03
1.123ThrLys: 1.123 ± 0.025
5.878ThrLeu: 5.878 ± 0.045
0.934ThrMet: 0.934 ± 0.018
0.988ThrAsn: 0.988 ± 0.022
4.205ThrPro: 4.205 ± 0.043
1.382ThrGln: 1.382 ± 0.02
4.12ThrArg: 4.12 ± 0.039
3.232ThrSer: 3.232 ± 0.045
3.939ThrThr: 3.939 ± 0.049
6.394ThrVal: 6.394 ± 0.047
0.909ThrTrp: 0.909 ± 0.019
1.388ThrTyr: 1.388 ± 0.025
0.0ThrXaa: 0.0 ± 0.0
Val
10.92ValAla: 10.92 ± 0.065
0.791ValCys: 0.791 ± 0.018
4.882ValAsp: 4.882 ± 0.044
4.384ValGlu: 4.384 ± 0.039
2.517ValPhe: 2.517 ± 0.033
6.54ValGly: 6.54 ± 0.06
2.03ValHis: 2.03 ± 0.029
2.908ValIle: 2.908 ± 0.037
1.667ValLys: 1.667 ± 0.029
9.633ValLeu: 9.633 ± 0.078
1.36ValMet: 1.36 ± 0.023
1.685ValAsn: 1.685 ± 0.028
5.411ValPro: 5.411 ± 0.053
2.145ValGln: 2.145 ± 0.03
7.506ValArg: 7.506 ± 0.06
4.354ValSer: 4.354 ± 0.037
5.993ValThr: 5.993 ± 0.053
8.085ValVal: 8.085 ± 0.073
1.171ValTrp: 1.171 ± 0.02
1.552ValTyr: 1.552 ± 0.026
0.0ValXaa: 0.0 ± 0.0
Trp
1.665TrpAla: 1.665 ± 0.027
0.159TrpCys: 0.159 ± 0.008
0.831TrpAsp: 0.831 ± 0.017
0.68TrpGlu: 0.68 ± 0.017
0.486TrpPhe: 0.486 ± 0.014
1.052TrpGly: 1.052 ± 0.02
0.371TrpHis: 0.371 ± 0.012
0.585TrpIle: 0.585 ± 0.015
0.354TrpLys: 0.354 ± 0.013
1.769TrpLeu: 1.769 ± 0.029
0.268TrpMet: 0.268 ± 0.009
0.402TrpAsn: 0.402 ± 0.014
0.776TrpPro: 0.776 ± 0.018
0.648TrpGln: 0.648 ± 0.017
1.345TrpArg: 1.345 ± 0.025
0.906TrpSer: 0.906 ± 0.022
1.051TrpThr: 1.051 ± 0.02
0.973TrpVal: 0.973 ± 0.02
0.32TrpTrp: 0.32 ± 0.011
0.382TrpTyr: 0.382 ± 0.011
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.799TyrAla: 2.799 ± 0.029
0.176TyrCys: 0.176 ± 0.008
1.519TyrAsp: 1.519 ± 0.028
1.195TyrGlu: 1.195 ± 0.02
0.657TyrPhe: 0.657 ± 0.015
2.288TyrGly: 2.288 ± 0.028
0.4TyrHis: 0.4 ± 0.013
0.487TyrIle: 0.487 ± 0.014
0.356TyrLys: 0.356 ± 0.013
2.096TyrLeu: 2.096 ± 0.028
0.228TyrMet: 0.228 ± 0.01
0.406TyrAsn: 0.406 ± 0.013
1.09TyrPro: 1.09 ± 0.019
0.632TyrGln: 0.632 ± 0.018
1.857TyrArg: 1.857 ± 0.027
0.948TyrSer: 0.948 ± 0.019
1.209TyrThr: 1.209 ± 0.023
1.687TyrVal: 1.687 ± 0.027
0.347TyrTrp: 0.347 ± 0.009
0.463TyrTyr: 0.463 ± 0.015
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 8654 proteins (2837391 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski