Amino acid dipepetide frequency for Human parainfluenza 2 virus (strain Toshiba) (HPIV-2)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
6.705AlaAla: 6.705 ± 1.343
0.813AlaCys: 0.813 ± 0.545
3.86AlaAsp: 3.86 ± 0.665
4.267AlaGlu: 4.267 ± 0.781
3.048AlaPhe: 3.048 ± 0.767
5.079AlaGly: 5.079 ± 1.148
1.016AlaHis: 1.016 ± 0.315
3.86AlaIle: 3.86 ± 1.633
3.657AlaLys: 3.657 ± 0.763
5.486AlaLeu: 5.486 ± 1.147
1.829AlaMet: 1.829 ± 1.2
4.673AlaAsn: 4.673 ± 2.256
1.422AlaPro: 1.422 ± 0.419
2.032AlaGln: 2.032 ± 0.666
3.657AlaArg: 3.657 ± 1.259
5.892AlaSer: 5.892 ± 0.744
5.486AlaThr: 5.486 ± 1.231
3.048AlaVal: 3.048 ± 0.446
0.813AlaTrp: 0.813 ± 0.336
1.422AlaTyr: 1.422 ± 0.586
0.0AlaXaa: 0.0 ± 0.0
Cys
1.016CysAla: 1.016 ± 0.309
0.203CysCys: 0.203 ± 0.129
0.203CysAsp: 0.203 ± 0.129
0.61CysGlu: 0.61 ± 0.386
1.016CysPhe: 1.016 ± 0.499
0.813CysGly: 0.813 ± 0.552
0.203CysHis: 0.203 ± 0.294
0.813CysIle: 0.813 ± 0.321
0.813CysLys: 0.813 ± 0.701
2.032CysLeu: 2.032 ± 0.53
1.016CysMet: 1.016 ± 0.513
1.219CysAsn: 1.219 ± 0.511
0.61CysPro: 0.61 ± 0.506
0.406CysGln: 0.406 ± 0.258
1.422CysArg: 1.422 ± 0.648
2.032CysSer: 2.032 ± 0.53
1.422CysThr: 1.422 ± 0.624
0.61CysVal: 0.61 ± 0.274
0.0CysTrp: 0.0 ± 0.0
1.016CysTyr: 1.016 ± 0.496
0.0CysXaa: 0.0 ± 0.0
Asp
3.251AspAla: 3.251 ± 0.859
0.813AspCys: 0.813 ± 0.321
2.438AspAsp: 2.438 ± 0.871
1.829AspGlu: 1.829 ± 0.566
2.641AspPhe: 2.641 ± 0.428
2.641AspGly: 2.641 ± 0.48
0.61AspHis: 0.61 ± 0.32
4.876AspIle: 4.876 ± 1.261
1.625AspLys: 1.625 ± 0.455
5.689AspLeu: 5.689 ± 1.289
0.61AspMet: 0.61 ± 0.442
2.641AspAsn: 2.641 ± 0.855
4.267AspPro: 4.267 ± 0.784
2.438AspGln: 2.438 ± 0.71
2.235AspArg: 2.235 ± 0.594
3.048AspSer: 3.048 ± 0.666
4.063AspThr: 4.063 ± 0.897
1.625AspVal: 1.625 ± 0.583
0.61AspTrp: 0.61 ± 0.248
2.032AspTyr: 2.032 ± 0.81
0.0AspXaa: 0.0 ± 0.0
Glu
1.625GluAla: 1.625 ± 0.882
0.61GluCys: 0.61 ± 0.32
2.438GluAsp: 2.438 ± 0.944
2.438GluGlu: 2.438 ± 0.684
1.219GluPhe: 1.219 ± 0.316
2.641GluGly: 2.641 ± 0.747
0.406GluHis: 0.406 ± 0.369
5.079GluIle: 5.079 ± 1.685
2.438GluLys: 2.438 ± 0.513
6.298GluLeu: 6.298 ± 1.014
1.219GluMet: 1.219 ± 0.279
2.844GluAsn: 2.844 ± 0.555
1.422GluPro: 1.422 ± 0.947
2.235GluGln: 2.235 ± 0.696
1.829GluArg: 1.829 ± 0.398
4.47GluSer: 4.47 ± 0.79
3.048GluThr: 3.048 ± 0.836
1.422GluVal: 1.422 ± 0.451
0.61GluTrp: 0.61 ± 0.551
1.625GluTyr: 1.625 ± 0.383
0.0GluXaa: 0.0 ± 0.0
Phe
1.829PheAla: 1.829 ± 0.895
0.813PheCys: 0.813 ± 0.262
2.438PheAsp: 2.438 ± 1.135
3.048PheGlu: 3.048 ± 0.883
3.048PhePhe: 3.048 ± 0.464
0.203PheGly: 0.203 ± 0.129
1.016PheHis: 1.016 ± 0.455
2.844PheIle: 2.844 ± 0.752
1.219PheLys: 1.219 ± 0.531
3.657PheLeu: 3.657 ± 0.471
0.406PheMet: 0.406 ± 0.228
2.235PheAsn: 2.235 ± 0.783
2.032PhePro: 2.032 ± 0.773
1.016PheGln: 1.016 ± 0.509
2.235PheArg: 2.235 ± 0.386
3.454PheSer: 3.454 ± 0.606
2.641PheThr: 2.641 ± 0.575
2.235PheVal: 2.235 ± 0.954
0.0PheTrp: 0.0 ± 0.0
1.219PheTyr: 1.219 ± 0.605
0.0PheXaa: 0.0 ± 0.0
Gly
3.657GlyAla: 3.657 ± 0.727
1.219GlyCys: 1.219 ± 0.549
3.454GlyAsp: 3.454 ± 0.961
3.251GlyGlu: 3.251 ± 0.861
2.438GlyPhe: 2.438 ± 0.515
2.844GlyGly: 2.844 ± 0.417
1.219GlyHis: 1.219 ± 0.507
4.673GlyIle: 4.673 ± 1.265
3.454GlyLys: 3.454 ± 1.354
3.86GlyLeu: 3.86 ± 0.573
1.219GlyMet: 1.219 ± 0.668
2.235GlyAsn: 2.235 ± 0.949
2.032GlyPro: 2.032 ± 1.0
1.219GlyGln: 1.219 ± 0.572
2.438GlyArg: 2.438 ± 0.667
5.079GlySer: 5.079 ± 1.373
2.844GlyThr: 2.844 ± 0.574
4.47GlyVal: 4.47 ± 1.187
0.0GlyTrp: 0.0 ± 0.0
0.406GlyTyr: 0.406 ± 0.258
0.0GlyXaa: 0.0 ± 0.0
His
1.422HisAla: 1.422 ± 0.644
0.0HisCys: 0.0 ± 0.0
1.016HisAsp: 1.016 ± 0.308
0.61HisGlu: 0.61 ± 0.323
0.61HisPhe: 0.61 ± 0.264
0.813HisGly: 0.813 ± 0.702
1.016HisHis: 1.016 ± 0.428
1.422HisIle: 1.422 ± 0.496
0.813HisLys: 0.813 ± 0.262
3.251HisLeu: 3.251 ± 0.984
0.203HisMet: 0.203 ± 0.261
1.219HisAsn: 1.219 ± 0.269
1.625HisPro: 1.625 ± 0.419
1.219HisGln: 1.219 ± 0.284
1.016HisArg: 1.016 ± 0.351
2.438HisSer: 2.438 ± 0.721
1.625HisThr: 1.625 ± 0.571
0.61HisVal: 0.61 ± 0.357
0.406HisTrp: 0.406 ± 0.229
0.406HisTyr: 0.406 ± 0.228
0.0HisXaa: 0.0 ± 0.0
Ile
5.079IleAla: 5.079 ± 1.619
1.219IleCys: 1.219 ± 0.477
5.486IleAsp: 5.486 ± 0.831
4.063IleGlu: 4.063 ± 0.787
2.844IlePhe: 2.844 ± 0.767
3.048IleGly: 3.048 ± 0.694
3.048IleHis: 3.048 ± 0.834
8.33IleIle: 8.33 ± 1.818
4.673IleLys: 4.673 ± 0.784
6.908IleLeu: 6.908 ± 1.512
1.625IleMet: 1.625 ± 0.365
4.673IleAsn: 4.673 ± 1.582
6.705IlePro: 6.705 ± 2.039
3.86IleGln: 3.86 ± 1.056
3.86IleArg: 3.86 ± 0.932
8.533IleSer: 8.533 ± 1.434
6.095IleThr: 6.095 ± 1.304
4.063IleVal: 4.063 ± 1.381
0.813IleTrp: 0.813 ± 0.516
2.032IleTyr: 2.032 ± 0.753
0.0IleXaa: 0.0 ± 0.0
Lys
2.844LysAla: 2.844 ± 0.275
1.016LysCys: 1.016 ± 0.32
2.235LysAsp: 2.235 ± 0.753
2.032LysGlu: 2.032 ± 0.782
2.032LysPhe: 2.032 ± 0.705
2.641LysGly: 2.641 ± 0.933
0.61LysHis: 0.61 ± 0.291
3.251LysIle: 3.251 ± 0.682
2.235LysLys: 2.235 ± 0.857
7.111LysLeu: 7.111 ± 1.202
1.016LysMet: 1.016 ± 0.515
2.235LysAsn: 2.235 ± 0.57
1.829LysPro: 1.829 ± 0.892
2.235LysGln: 2.235 ± 0.5
3.251LysArg: 3.251 ± 0.81
4.267LysSer: 4.267 ± 1.669
3.048LysThr: 3.048 ± 0.373
2.641LysVal: 2.641 ± 0.827
0.406LysTrp: 0.406 ± 0.258
2.235LysTyr: 2.235 ± 0.848
0.0LysXaa: 0.0 ± 0.0
Leu
9.752LeuAla: 9.752 ± 0.982
1.625LeuCys: 1.625 ± 0.489
5.079LeuAsp: 5.079 ± 0.893
4.876LeuGlu: 4.876 ± 1.696
2.438LeuPhe: 2.438 ± 0.762
6.095LeuGly: 6.095 ± 0.721
2.438LeuHis: 2.438 ± 0.44
10.565LeuIle: 10.565 ± 1.971
6.095LeuLys: 6.095 ± 0.79
9.955LeuLeu: 9.955 ± 0.743
3.454LeuMet: 3.454 ± 0.6
6.095LeuAsn: 6.095 ± 0.827
5.282LeuPro: 5.282 ± 0.733
3.657LeuGln: 3.657 ± 1.094
4.063LeuArg: 4.063 ± 0.634
7.314LeuSer: 7.314 ± 1.196
7.111LeuThr: 7.111 ± 1.534
4.267LeuVal: 4.267 ± 0.998
1.422LeuTrp: 1.422 ± 0.688
2.438LeuTyr: 2.438 ± 0.925
0.0LeuXaa: 0.0 ± 0.0
Met
1.625MetAla: 1.625 ± 0.687
0.406MetCys: 0.406 ± 0.258
0.813MetAsp: 0.813 ± 0.57
1.016MetGlu: 1.016 ± 0.348
0.61MetPhe: 0.61 ± 0.274
1.625MetGly: 1.625 ± 1.004
1.219MetHis: 1.219 ± 0.697
1.219MetIle: 1.219 ± 0.454
1.219MetLys: 1.219 ± 0.503
1.422MetLeu: 1.422 ± 0.488
0.61MetMet: 0.61 ± 0.432
0.813MetAsn: 0.813 ± 0.347
0.813MetPro: 0.813 ± 0.28
1.219MetGln: 1.219 ± 0.65
1.219MetArg: 1.219 ± 0.568
2.438MetSer: 2.438 ± 1.079
1.625MetThr: 1.625 ± 0.809
0.813MetVal: 0.813 ± 0.456
0.406MetTrp: 0.406 ± 0.258
1.422MetTyr: 1.422 ± 0.673
0.0MetXaa: 0.0 ± 0.0
Asn
3.048AsnAla: 3.048 ± 0.888
0.61AsnCys: 0.61 ± 0.515
3.657AsnAsp: 3.657 ± 1.515
2.032AsnGlu: 2.032 ± 1.498
2.032AsnPhe: 2.032 ± 0.654
4.063AsnGly: 4.063 ± 1.068
1.422AsnHis: 1.422 ± 0.758
4.673AsnIle: 4.673 ± 1.016
1.625AsnLys: 1.625 ± 0.49
4.876AsnLeu: 4.876 ± 1.149
0.406AsnMet: 0.406 ± 0.343
3.251AsnAsn: 3.251 ± 1.234
4.063AsnPro: 4.063 ± 0.398
2.844AsnGln: 2.844 ± 1.031
2.438AsnArg: 2.438 ± 0.872
3.251AsnSer: 3.251 ± 0.63
4.063AsnThr: 4.063 ± 1.063
2.032AsnVal: 2.032 ± 0.741
0.61AsnTrp: 0.61 ± 0.387
2.438AsnTyr: 2.438 ± 0.474
0.0AsnXaa: 0.0 ± 0.0
Pro
2.438ProAla: 2.438 ± 0.949
0.203ProCys: 0.203 ± 0.231
2.235ProAsp: 2.235 ± 0.764
2.438ProGlu: 2.438 ± 0.426
2.235ProPhe: 2.235 ± 0.703
3.251ProGly: 3.251 ± 0.424
1.625ProHis: 1.625 ± 0.494
5.079ProIle: 5.079 ± 1.495
1.829ProLys: 1.829 ± 0.61
5.892ProLeu: 5.892 ± 0.41
1.422ProMet: 1.422 ± 0.416
3.657ProAsn: 3.657 ± 1.63
3.454ProPro: 3.454 ± 0.556
1.219ProGln: 1.219 ± 0.434
2.235ProArg: 2.235 ± 0.544
3.86ProSer: 3.86 ± 0.769
4.267ProThr: 4.267 ± 1.209
3.86ProVal: 3.86 ± 1.71
0.0ProTrp: 0.0 ± 0.0
2.032ProTyr: 2.032 ± 0.922
0.0ProXaa: 0.0 ± 0.0
Gln
2.844GlnAla: 2.844 ± 0.68
0.203GlnCys: 0.203 ± 0.269
2.235GlnAsp: 2.235 ± 0.795
1.829GlnGlu: 1.829 ± 0.363
0.406GlnPhe: 0.406 ± 0.224
2.032GlnGly: 2.032 ± 0.354
0.813GlnHis: 0.813 ± 0.347
3.454GlnIle: 3.454 ± 1.23
1.625GlnLys: 1.625 ± 0.417
4.673GlnLeu: 4.673 ± 1.067
0.813GlnMet: 0.813 ± 0.325
1.219GlnAsn: 1.219 ± 0.294
1.829GlnPro: 1.829 ± 0.932
2.438GlnGln: 2.438 ± 1.461
2.032GlnArg: 2.032 ± 0.676
3.86GlnSer: 3.86 ± 0.507
2.235GlnThr: 2.235 ± 0.618
2.438GlnVal: 2.438 ± 0.885
1.016GlnTrp: 1.016 ± 0.507
1.625GlnTyr: 1.625 ± 0.687
0.0GlnXaa: 0.0 ± 0.0
Arg
1.625ArgAla: 1.625 ± 0.465
1.219ArgCys: 1.219 ± 0.487
0.813ArgAsp: 0.813 ± 0.387
2.641ArgGlu: 2.641 ± 1.045
2.032ArgPhe: 2.032 ± 0.706
2.641ArgGly: 2.641 ± 0.97
1.016ArgHis: 1.016 ± 0.32
3.86ArgIle: 3.86 ± 0.801
3.657ArgLys: 3.657 ± 0.825
4.267ArgLeu: 4.267 ± 1.296
0.61ArgMet: 0.61 ± 0.387
1.422ArgAsn: 1.422 ± 0.35
2.235ArgPro: 2.235 ± 1.427
1.219ArgGln: 1.219 ± 0.353
2.235ArgArg: 2.235 ± 0.775
6.095ArgSer: 6.095 ± 0.729
3.657ArgThr: 3.657 ± 0.667
2.844ArgVal: 2.844 ± 1.109
0.406ArgTrp: 0.406 ± 0.228
2.235ArgTyr: 2.235 ± 0.656
0.0ArgXaa: 0.0 ± 0.0
Ser
6.298SerAla: 6.298 ± 2.025
1.829SerCys: 1.829 ± 0.477
3.86SerAsp: 3.86 ± 0.876
3.454SerGlu: 3.454 ± 0.623
2.641SerPhe: 2.641 ± 0.708
2.844SerGly: 2.844 ± 0.92
1.422SerHis: 1.422 ± 0.904
7.72SerIle: 7.72 ± 1.554
4.876SerLys: 4.876 ± 0.99
10.565SerLeu: 10.565 ± 0.619
2.641SerMet: 2.641 ± 0.469
5.079SerAsn: 5.079 ± 0.813
3.251SerPro: 3.251 ± 1.454
3.657SerGln: 3.657 ± 0.731
4.267SerArg: 4.267 ± 0.627
8.533SerSer: 8.533 ± 1.532
3.86SerThr: 3.86 ± 0.839
3.657SerVal: 3.657 ± 0.453
1.219SerTrp: 1.219 ± 0.617
4.47SerTyr: 4.47 ± 0.93
0.0SerXaa: 0.0 ± 0.0
Thr
6.908ThrAla: 6.908 ± 0.978
1.829ThrCys: 1.829 ± 0.784
4.063ThrAsp: 4.063 ± 0.548
2.438ThrGlu: 2.438 ± 1.053
3.657ThrPhe: 3.657 ± 0.857
3.454ThrGly: 3.454 ± 0.876
1.219ThrHis: 1.219 ± 0.582
6.501ThrIle: 6.501 ± 0.845
2.438ThrLys: 2.438 ± 1.024
7.111ThrLeu: 7.111 ± 1.427
1.219ThrMet: 1.219 ± 0.279
3.251ThrAsn: 3.251 ± 0.653
5.079ThrPro: 5.079 ± 0.921
2.032ThrGln: 2.032 ± 0.853
3.454ThrArg: 3.454 ± 0.549
5.282ThrSer: 5.282 ± 1.531
4.47ThrThr: 4.47 ± 1.003
3.048ThrVal: 3.048 ± 0.651
0.203ThrTrp: 0.203 ± 0.129
2.032ThrTyr: 2.032 ± 0.584
0.0ThrXaa: 0.0 ± 0.0
Val
3.048ValAla: 3.048 ± 0.348
1.219ValCys: 1.219 ± 0.548
2.438ValAsp: 2.438 ± 0.882
2.032ValGlu: 2.032 ± 0.887
1.625ValPhe: 1.625 ± 0.346
2.844ValGly: 2.844 ± 0.536
0.813ValHis: 0.813 ± 0.325
5.282ValIle: 5.282 ± 0.974
2.844ValLys: 2.844 ± 0.953
5.486ValLeu: 5.486 ± 0.962
1.219ValMet: 1.219 ± 0.89
1.219ValAsn: 1.219 ± 0.284
3.454ValPro: 3.454 ± 0.508
1.219ValGln: 1.219 ± 0.495
1.625ValArg: 1.625 ± 0.694
3.048ValSer: 3.048 ± 0.904
3.86ValThr: 3.86 ± 1.136
3.657ValVal: 3.657 ± 2.062
0.406ValTrp: 0.406 ± 0.324
2.438ValTyr: 2.438 ± 0.71
0.0ValXaa: 0.0 ± 0.0
Trp
0.61TrpAla: 0.61 ± 0.291
0.61TrpCys: 0.61 ± 0.302
0.203TrpAsp: 0.203 ± 0.129
0.203TrpGlu: 0.203 ± 0.129
0.203TrpPhe: 0.203 ± 0.129
0.61TrpGly: 0.61 ± 0.309
0.0TrpHis: 0.0 ± 0.0
1.219TrpIle: 1.219 ± 0.284
0.406TrpLys: 0.406 ± 0.258
0.813TrpLeu: 0.813 ± 0.516
0.203TrpMet: 0.203 ± 0.129
0.61TrpAsn: 0.61 ± 0.387
0.813TrpPro: 0.813 ± 0.323
0.61TrpGln: 0.61 ± 0.387
0.406TrpArg: 0.406 ± 0.258
0.813TrpSer: 0.813 ± 0.36
0.406TrpThr: 0.406 ± 0.258
0.406TrpVal: 0.406 ± 0.341
0.203TrpTrp: 0.203 ± 0.231
0.406TrpTyr: 0.406 ± 0.258
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.438TyrAla: 2.438 ± 0.843
1.016TyrCys: 1.016 ± 0.507
1.016TyrAsp: 1.016 ± 0.476
0.813TyrGlu: 0.813 ± 0.347
0.813TyrPhe: 0.813 ± 0.331
1.829TyrGly: 1.829 ± 0.505
0.61TyrHis: 0.61 ± 0.442
2.235TyrIle: 2.235 ± 0.398
1.625TyrLys: 1.625 ± 0.694
4.876TyrLeu: 4.876 ± 1.956
0.61TyrMet: 0.61 ± 0.298
2.844TyrAsn: 2.844 ± 0.712
1.016TyrPro: 1.016 ± 0.282
2.844TyrGln: 2.844 ± 0.575
0.813TyrArg: 0.813 ± 0.514
2.438TyrSer: 2.438 ± 0.44
3.86TyrThr: 3.86 ± 0.798
2.032TyrVal: 2.032 ± 0.621
0.203TyrTrp: 0.203 ± 0.129
2.235TyrTyr: 2.235 ± 0.853
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 7 proteins (4923 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski