Amino acid dipepetide frequency for Desertifilum sp. IPPAS B-1220

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	8.057AlaAla: 8.057 ± 0.089	0.92AlaCys: 0.92 ± 0.022	4.156AlaAsp: 4.156 ± 0.053	5.853AlaGlu: 5.853 ± 0.073	3.221AlaPhe: 3.221 ± 0.048	5.698AlaGly: 5.698 ± 0.079	1.449AlaHis: 1.449 ± 0.029	8.236AlaIle: 8.236 ± 0.088	3.386AlaLys: 3.386 ± 0.048	9.928AlaLeu: 9.928 ± 0.088	1.708AlaMet: 1.708 ± 0.034	3.495AlaAsn: 3.495 ± 0.069	3.472AlaPro: 3.472 ± 0.057	5.428AlaGln: 5.428 ± 0.059	4.155AlaArg: 4.155 ± 0.055	5.336AlaSer: 5.336 ± 0.067	5.066AlaThr: 5.066 ± 0.058	5.649AlaVal: 5.649 ± 0.062	1.168AlaTrp: 1.168 ± 0.028	2.576AlaTyr: 2.576 ± 0.048	0.0AlaXaa: 0.0 ± 0.0
Cys	0.674CysAla: 0.674 ± 0.022	0.182CysCys: 0.182 ± 0.012	0.641CysAsp: 0.641 ± 0.019	0.534CysGlu: 0.534 ± 0.018	0.433CysPhe: 0.433 ± 0.016	0.78CysGly: 0.78 ± 0.027	0.269CysHis: 0.269 ± 0.013	0.549CysIle: 0.549 ± 0.018	0.295CysLys: 0.295 ± 0.016	1.123CysLeu: 1.123 ± 0.027	0.158CysMet: 0.158 ± 0.012	0.328CysAsn: 0.328 ± 0.017	0.551CysPro: 0.551 ± 0.018	0.676CysGln: 0.676 ± 0.022	0.549CysArg: 0.549 ± 0.018	0.521CysSer: 0.521 ± 0.017	0.489CysThr: 0.489 ± 0.016	0.565CysVal: 0.565 ± 0.02	0.162CysTrp: 0.162 ± 0.011	0.352CysTyr: 0.352 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	3.874AspAla: 3.874 ± 0.042	0.533AspCys: 0.533 ± 0.018	2.01AspAsp: 2.01 ± 0.051	2.907AspGlu: 2.907 ± 0.055	2.26AspPhe: 2.26 ± 0.041	3.136AspGly: 3.136 ± 0.055	0.549AspHis: 0.549 ± 0.016	3.065AspIle: 3.065 ± 0.045	1.443AspLys: 1.443 ± 0.028	6.016AspLeu: 6.016 ± 0.063	0.681AspMet: 0.681 ± 0.02	1.679AspAsn: 1.679 ± 0.038	2.832AspPro: 2.832 ± 0.054	1.335AspGln: 1.335 ± 0.032	5.185AspArg: 5.185 ± 0.056	2.789AspSer: 2.789 ± 0.048	2.392AspThr: 2.392 ± 0.058	2.66AspVal: 2.66 ± 0.045	0.917AspTrp: 0.917 ± 0.024	1.788AspTyr: 1.788 ± 0.037	0.0AspXaa: 0.0 ± 0.0
Glu	6.456GluAla: 6.456 ± 0.078	0.532GluCys: 0.532 ± 0.02	2.757GluAsp: 2.757 ± 0.042	4.151GluGlu: 4.151 ± 0.102	2.482GluPhe: 2.482 ± 0.039	3.621GluGly: 3.621 ± 0.053	0.914GluHis: 0.914 ± 0.028	4.556GluIle: 4.556 ± 0.057	2.628GluLys: 2.628 ± 0.048	7.143GluLeu: 7.143 ± 0.086	1.349GluMet: 1.349 ± 0.03	2.4GluAsn: 2.4 ± 0.043	2.724GluPro: 2.724 ± 0.05	3.77GluGln: 3.77 ± 0.057	4.039GluArg: 4.039 ± 0.057	3.473GluSer: 3.473 ± 0.062	3.898GluThr: 3.898 ± 0.069	4.5GluVal: 4.5 ± 0.052	0.872GluTrp: 0.872 ± 0.027	1.741GluTyr: 1.741 ± 0.033	0.0GluXaa: 0.0 ± 0.0
Phe	3.271PheAla: 3.271 ± 0.053	0.492PheCys: 0.492 ± 0.016	2.073PheAsp: 2.073 ± 0.042	2.185PheGlu: 2.185 ± 0.04	1.637PhePhe: 1.637 ± 0.034	2.875PheGly: 2.875 ± 0.053	0.694PheHis: 0.694 ± 0.02	2.13PheIle: 2.13 ± 0.037	1.203PheLys: 1.203 ± 0.031	4.144PheLeu: 4.144 ± 0.067	0.662PheMet: 0.662 ± 0.019	1.669PheAsn: 1.669 ± 0.034	1.911PhePro: 1.911 ± 0.035	1.869PheGln: 1.869 ± 0.037	1.932PheArg: 1.932 ± 0.038	2.908PheSer: 2.908 ± 0.045	2.165PheThr: 2.165 ± 0.038	2.333PheVal: 2.333 ± 0.04	0.754PheTrp: 0.754 ± 0.026	1.313PheTyr: 1.313 ± 0.03	0.0PheXaa: 0.0 ± 0.0
Gly	5.021GlyAla: 5.021 ± 0.085	0.787GlyCys: 0.787 ± 0.025	3.562GlyAsp: 3.562 ± 0.082	4.461GlyGlu: 4.461 ± 0.056	2.93GlyPhe: 2.93 ± 0.042	5.051GlyGly: 5.051 ± 0.12	1.163GlyHis: 1.163 ± 0.029	4.81GlyIle: 4.81 ± 0.053	3.223GlyLys: 3.223 ± 0.052	7.318GlyLeu: 7.318 ± 0.083	1.496GlyMet: 1.496 ± 0.032	2.873GlyAsn: 2.873 ± 0.093	1.585GlyPro: 1.585 ± 0.032	3.365GlyGln: 3.365 ± 0.055	3.555GlyArg: 3.555 ± 0.048	4.15GlySer: 4.15 ± 0.075	4.128GlyThr: 4.128 ± 0.073	5.006GlyVal: 5.006 ± 0.062	1.284GlyTrp: 1.284 ± 0.034	2.37GlyTyr: 2.37 ± 0.041	0.0GlyXaa: 0.0 ± 0.0
His	1.222HisAla: 1.222 ± 0.03	0.288HisCys: 0.288 ± 0.014	0.643HisAsp: 0.643 ± 0.021	0.899HisGlu: 0.899 ± 0.024	0.789HisPhe: 0.789 ± 0.024	0.98HisGly: 0.98 ± 0.024	0.628HisHis: 0.628 ± 0.025	0.928HisIle: 0.928 ± 0.021	0.557HisLys: 0.557 ± 0.023	2.544HisLeu: 2.544 ± 0.045	0.215HisMet: 0.215 ± 0.011	0.609HisAsn: 0.609 ± 0.021	1.606HisPro: 1.606 ± 0.035	1.346HisGln: 1.346 ± 0.034	1.279HisArg: 1.279 ± 0.026	1.226HisSer: 1.226 ± 0.031	0.785HisThr: 0.785 ± 0.021	0.736HisVal: 0.736 ± 0.023	0.357HisTrp: 0.357 ± 0.015	0.743HisTyr: 0.743 ± 0.021	0.0HisXaa: 0.0 ± 0.0
Ile	7.972IleAla: 7.972 ± 0.08	0.639IleCys: 0.639 ± 0.022	3.293IleAsp: 3.293 ± 0.052	4.177IleGlu: 4.177 ± 0.055	2.263IlePhe: 2.263 ± 0.041	4.266IleGly: 4.266 ± 0.054	1.248IleHis: 1.248 ± 0.027	2.889IleIle: 2.889 ± 0.042	1.851IleLys: 1.851 ± 0.036	6.728IleLeu: 6.728 ± 0.074	0.639IleMet: 0.639 ± 0.018	2.144IleAsn: 2.144 ± 0.045	3.589IlePro: 3.589 ± 0.052	3.359IleGln: 3.359 ± 0.05	3.35IleArg: 3.35 ± 0.045	3.822IleSer: 3.822 ± 0.05	2.956IleThr: 2.956 ± 0.049	4.083IleVal: 4.083 ± 0.056	0.795IleTrp: 0.795 ± 0.023	1.734IleTyr: 1.734 ± 0.033	0.0IleXaa: 0.0 ± 0.0
Lys	3.456LysAla: 3.456 ± 0.057	0.239LysCys: 0.239 ± 0.013	1.539LysAsp: 1.539 ± 0.037	1.884LysGlu: 1.884 ± 0.045	1.204LysPhe: 1.204 ± 0.027	2.162LysGly: 2.162 ± 0.039	0.691LysHis: 0.691 ± 0.021	2.414LysIle: 2.414 ± 0.043	1.396LysLys: 1.396 ± 0.036	3.98LysLeu: 3.98 ± 0.058	0.715LysMet: 0.715 ± 0.021	1.255LysAsn: 1.255 ± 0.033	2.103LysPro: 2.103 ± 0.036	2.142LysGln: 2.142 ± 0.036	2.149LysArg: 2.149 ± 0.042	2.128LysSer: 2.128 ± 0.04	2.297LysThr: 2.297 ± 0.043	2.33LysVal: 2.33 ± 0.045	0.378LysTrp: 0.378 ± 0.014	0.902LysTyr: 0.902 ± 0.027	0.0LysXaa: 0.0 ± 0.0
Leu	10.653LeuAla: 10.653 ± 0.095	1.074LeuCys: 1.074 ± 0.025	5.562LeuAsp: 5.562 ± 0.06	8.044LeuGlu: 8.044 ± 0.089	3.954LeuPhe: 3.954 ± 0.051	8.198LeuGly: 8.198 ± 0.09	2.034LeuHis: 2.034 ± 0.037	6.455LeuIle: 6.455 ± 0.08	4.901LeuLys: 4.901 ± 0.059	12.014LeuLeu: 12.014 ± 0.119	2.204LeuMet: 2.204 ± 0.038	4.604LeuAsn: 4.604 ± 0.057	6.093LeuPro: 6.093 ± 0.071	6.584LeuGln: 6.584 ± 0.076	6.07LeuArg: 6.07 ± 0.066	8.149LeuSer: 8.149 ± 0.08	6.504LeuThr: 6.504 ± 0.064	7.256LeuVal: 7.256 ± 0.071	1.632LeuTrp: 1.632 ± 0.043	2.905LeuTyr: 2.905 ± 0.051	0.0LeuXaa: 0.0 ± 0.0
Met	1.789MetAla: 1.789 ± 0.032	0.102MetCys: 0.102 ± 0.009	0.753MetAsp: 0.753 ± 0.02	0.904MetGlu: 0.904 ± 0.025	0.494MetPhe: 0.494 ± 0.017	1.422MetGly: 1.422 ± 0.033	0.31MetHis: 0.31 ± 0.015	0.928MetIle: 0.928 ± 0.024	0.725MetLys: 0.725 ± 0.019	1.777MetLeu: 1.777 ± 0.033	0.406MetMet: 0.406 ± 0.016	0.78MetAsn: 0.78 ± 0.022	0.941MetPro: 0.941 ± 0.028	0.981MetGln: 0.981 ± 0.022	1.039MetArg: 1.039 ± 0.024	1.303MetSer: 1.303 ± 0.028	1.187MetThr: 1.187 ± 0.026	1.223MetVal: 1.223 ± 0.027	0.145MetTrp: 0.145 ± 0.01	0.305MetTyr: 0.305 ± 0.013	0.0MetXaa: 0.0 ± 0.0
Asn	3.153AsnAla: 3.153 ± 0.052	0.408AsnCys: 0.408 ± 0.018	1.581AsnAsp: 1.581 ± 0.063	1.578AsnGlu: 1.578 ± 0.036	1.547AsnPhe: 1.547 ± 0.034	2.455AsnGly: 2.455 ± 0.056	0.711AsnHis: 0.711 ± 0.023	2.062AsnIle: 2.062 ± 0.046	0.867AsnLys: 0.867 ± 0.025	5.3AsnLeu: 5.3 ± 0.09	0.459AsnMet: 0.459 ± 0.016	1.376AsnAsn: 1.376 ± 0.047	3.035AsnPro: 3.035 ± 0.042	2.516AsnGln: 2.516 ± 0.039	2.59AsnArg: 2.59 ± 0.037	2.343AsnSer: 2.343 ± 0.042	1.842AsnThr: 1.842 ± 0.037	1.9AsnVal: 1.9 ± 0.04	0.693AsnTrp: 0.693 ± 0.021	1.144AsnTyr: 1.144 ± 0.026	0.0AsnXaa: 0.0 ± 0.0
Pro	3.874ProAla: 3.874 ± 0.055	0.37ProCys: 0.37 ± 0.015	3.234ProAsp: 3.234 ± 0.047	4.606ProGlu: 4.606 ± 0.068	1.926ProPhe: 1.926 ± 0.032	3.366ProGly: 3.366 ± 0.055	1.084ProHis: 1.084 ± 0.03	3.148ProIle: 3.148 ± 0.043	1.737ProLys: 1.737 ± 0.032	5.497ProLeu: 5.497 ± 0.066	0.833ProMet: 0.833 ± 0.023	2.267ProAsn: 2.267 ± 0.036	3.238ProPro: 3.238 ± 0.061	3.443ProGln: 3.443 ± 0.052	2.123ProArg: 2.123 ± 0.038	3.256ProSer: 3.256 ± 0.049	3.297ProThr: 3.297 ± 0.072	3.655ProVal: 3.655 ± 0.061	0.66ProTrp: 0.66 ± 0.021	1.414ProTyr: 1.414 ± 0.03	0.0ProXaa: 0.0 ± 0.0
Gln	6.146GlnAla: 6.146 ± 0.062	0.408GlnCys: 0.408 ± 0.015	2.198GlnAsp: 2.198 ± 0.035	3.52GlnGlu: 3.52 ± 0.05	2.048GlnPhe: 2.048 ± 0.041	3.764GlnGly: 3.764 ± 0.047	1.072GlnHis: 1.072 ± 0.027	3.752GlnIle: 3.752 ± 0.051	2.145GlnLys: 2.145 ± 0.037	6.993GlnLeu: 6.993 ± 0.082	1.123GlnMet: 1.123 ± 0.027	1.975GlnAsn: 1.975 ± 0.035	3.191GlnPro: 3.191 ± 0.047	4.436GlnGln: 4.436 ± 0.072	3.446GlnArg: 3.446 ± 0.05	3.178GlnSer: 3.178 ± 0.049	3.617GlnThr: 3.617 ± 0.052	4.174GlnVal: 4.174 ± 0.054	0.858GlnTrp: 0.858 ± 0.027	1.324GlnTyr: 1.324 ± 0.028	0.0GlnXaa: 0.0 ± 0.0
Arg	3.996ArgAla: 3.996 ± 0.053	0.544ArgCys: 0.544 ± 0.02	3.045ArgAsp: 3.045 ± 0.048	3.68ArgGlu: 3.68 ± 0.05	2.458ArgPhe: 2.458 ± 0.04	3.335ArgGly: 3.335 ± 0.049	1.146ArgHis: 1.146 ± 0.03	3.586ArgIle: 3.586 ± 0.051	1.947ArgLys: 1.947 ± 0.038	7.166ArgLeu: 7.166 ± 0.072	1.1ArgMet: 1.1 ± 0.027	2.095ArgAsn: 2.095 ± 0.035	2.519ArgPro: 2.519 ± 0.039	4.051ArgGln: 4.051 ± 0.055	3.485ArgArg: 3.485 ± 0.047	3.773ArgSer: 3.773 ± 0.054	2.988ArgThr: 2.988 ± 0.041	3.842ArgVal: 3.842 ± 0.054	1.015ArgTrp: 1.015 ± 0.033	2.186ArgTyr: 2.186 ± 0.038	0.0ArgXaa: 0.0 ± 0.0
Ser	5.237SerAla: 5.237 ± 0.057	0.579SerCys: 0.579 ± 0.019	3.251SerAsp: 3.251 ± 0.048	3.878SerGlu: 3.878 ± 0.072	2.27SerPhe: 2.27 ± 0.04	4.633SerGly: 4.633 ± 0.065	1.297SerHis: 1.297 ± 0.028	3.35SerIle: 3.35 ± 0.044	1.706SerLys: 1.706 ± 0.036	7.686SerLeu: 7.686 ± 0.085	1.074SerMet: 1.074 ± 0.026	2.139SerAsn: 2.139 ± 0.039	4.131SerPro: 4.131 ± 0.071	3.887SerGln: 3.887 ± 0.058	3.429SerArg: 3.429 ± 0.048	3.904SerSer: 3.904 ± 0.063	3.237SerThr: 3.237 ± 0.047	3.846SerVal: 3.846 ± 0.051	0.928SerTrp: 0.928 ± 0.024	1.718SerTyr: 1.718 ± 0.033	0.0SerXaa: 0.0 ± 0.0
Thr	4.927ThrAla: 4.927 ± 0.063	0.514ThrCys: 0.514 ± 0.02	2.485ThrAsp: 2.485 ± 0.047	3.32ThrGlu: 3.32 ± 0.055	2.013ThrPhe: 2.013 ± 0.038	4.424ThrGly: 4.424 ± 0.066	1.142ThrHis: 1.142 ± 0.027	3.241ThrIle: 3.241 ± 0.048	1.358ThrLys: 1.358 ± 0.033	7.309ThrLeu: 7.309 ± 0.079	0.638ThrMet: 0.638 ± 0.018	1.687ThrAsn: 1.687 ± 0.043	4.263ThrPro: 4.263 ± 0.079	3.49ThrGln: 3.49 ± 0.052	2.713ThrArg: 2.713 ± 0.041	3.116ThrSer: 3.116 ± 0.057	3.058ThrThr: 3.058 ± 0.047	3.699ThrVal: 3.699 ± 0.057	0.756ThrTrp: 0.756 ± 0.023	1.584ThrTyr: 1.584 ± 0.037	0.0ThrXaa: 0.0 ± 0.0
Val	6.017ValAla: 6.017 ± 0.063	0.676ValCys: 0.676 ± 0.019	3.186ValAsp: 3.186 ± 0.05	4.722ValGlu: 4.722 ± 0.062	2.475ValPhe: 2.475 ± 0.04	4.818ValGly: 4.818 ± 0.061	0.986ValHis: 0.986 ± 0.028	3.303ValIle: 3.303 ± 0.044	2.617ValLys: 2.617 ± 0.044	6.674ValLeu: 6.674 ± 0.073	1.331ValMet: 1.331 ± 0.029	2.558ValAsn: 2.558 ± 0.039	3.134ValPro: 3.134 ± 0.051	3.22ValGln: 3.22 ± 0.051	3.692ValArg: 3.692 ± 0.054	4.204ValSer: 4.204 ± 0.057	3.703ValThr: 3.703 ± 0.054	4.512ValVal: 4.512 ± 0.067	0.897ValTrp: 0.897 ± 0.025	1.851ValTyr: 1.851 ± 0.036	0.0ValXaa: 0.0 ± 0.0
Trp	0.963TrpAla: 0.963 ± 0.024	0.144TrpCys: 0.144 ± 0.009	0.704TrpAsp: 0.704 ± 0.022	1.018TrpGlu: 1.018 ± 0.032	0.589TrpPhe: 0.589 ± 0.019	1.087TrpGly: 1.087 ± 0.029	0.332TrpHis: 0.332 ± 0.015	0.9TrpIle: 0.9 ± 0.026	0.533TrpLys: 0.533 ± 0.018	1.906TrpLeu: 1.906 ± 0.04	0.356TrpMet: 0.356 ± 0.015	0.602TrpAsn: 0.602 ± 0.021	0.406TrpPro: 0.406 ± 0.016	1.302TrpGln: 1.302 ± 0.035	0.966TrpArg: 0.966 ± 0.027	0.818TrpSer: 0.818 ± 0.027	0.657TrpThr: 0.657 ± 0.021	1.086TrpVal: 1.086 ± 0.025	0.239TrpTrp: 0.239 ± 0.013	0.434TrpTyr: 0.434 ± 0.018	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.203TyrAla: 2.203 ± 0.04	0.402TyrCys: 0.402 ± 0.015	1.382TyrAsp: 1.382 ± 0.036	1.685TyrGlu: 1.685 ± 0.036	1.227TyrPhe: 1.227 ± 0.029	2.067TyrGly: 2.067 ± 0.041	0.66TyrHis: 0.66 ± 0.021	1.493TyrIle: 1.493 ± 0.031	0.846TyrLys: 0.846 ± 0.024	3.644TyrLeu: 3.644 ± 0.049	0.366TyrMet: 0.366 ± 0.014	1.024TyrAsn: 1.024 ± 0.029	1.704TyrPro: 1.704 ± 0.033	2.172TyrGln: 2.172 ± 0.042	2.209TyrArg: 2.209 ± 0.037	1.783TyrSer: 1.783 ± 0.036	1.469TyrThr: 1.469 ± 0.031	1.52TyrVal: 1.52 ± 0.034	0.528TyrTrp: 0.528 ± 0.021	1.006TyrTyr: 1.006 ± 0.028	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4964 proteins (1712571 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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