Amino acid dipepetide frequency for Corynebacterium kroppenstedtii (strain DSM 44385 / JCM 11950 / CIP 105744 / CCUG 35717)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
12.497AlaAla: 12.497 ± 0.163
0.909AlaCys: 0.909 ± 0.038
7.362AlaAsp: 7.362 ± 0.109
6.307AlaGlu: 6.307 ± 0.121
3.096AlaPhe: 3.096 ± 0.074
9.112AlaGly: 9.112 ± 0.118
2.674AlaHis: 2.674 ± 0.066
5.635AlaIle: 5.635 ± 0.097
3.546AlaLys: 3.546 ± 0.099
10.029AlaLeu: 10.029 ± 0.142
2.538AlaMet: 2.538 ± 0.06
2.824AlaAsn: 2.824 ± 0.062
4.63AlaPro: 4.63 ± 0.105
3.787AlaGln: 3.787 ± 0.074
6.614AlaArg: 6.614 ± 0.105
7.073AlaSer: 7.073 ± 0.11
6.558AlaThr: 6.558 ± 0.1
8.662AlaVal: 8.662 ± 0.12
1.432AlaTrp: 1.432 ± 0.047
2.085AlaTyr: 2.085 ± 0.055
0.0AlaXaa: 0.0 ± 0.0
Cys
0.956CysAla: 0.956 ± 0.039
0.099CysCys: 0.099 ± 0.013
0.546CysAsp: 0.546 ± 0.028
0.424CysGlu: 0.424 ± 0.023
0.268CysPhe: 0.268 ± 0.022
0.834CysGly: 0.834 ± 0.035
0.244CysHis: 0.244 ± 0.019
0.353CysIle: 0.353 ± 0.019
0.145CysLys: 0.145 ± 0.013
0.641CysLeu: 0.641 ± 0.03
0.139CysMet: 0.139 ± 0.014
0.177CysAsn: 0.177 ± 0.015
0.431CysPro: 0.431 ± 0.03
0.196CysGln: 0.196 ± 0.015
0.439CysArg: 0.439 ± 0.026
0.58CysSer: 0.58 ± 0.026
0.505CysThr: 0.505 ± 0.026
0.675CysVal: 0.675 ± 0.029
0.099CysTrp: 0.099 ± 0.01
0.153CysTyr: 0.153 ± 0.015
0.0CysXaa: 0.0 ± 0.0
Asp
7.32AspAla: 7.32 ± 0.106
0.454AspCys: 0.454 ± 0.028
5.523AspAsp: 5.523 ± 0.103
4.612AspGlu: 4.612 ± 0.102
1.941AspPhe: 1.941 ± 0.053
5.82AspGly: 5.82 ± 0.093
1.687AspHis: 1.687 ± 0.05
3.489AspIle: 3.489 ± 0.074
2.492AspLys: 2.492 ± 0.07
5.28AspLeu: 5.28 ± 0.097
1.297AspMet: 1.297 ± 0.041
2.298AspAsn: 2.298 ± 0.063
3.778AspPro: 3.778 ± 0.086
2.151AspGln: 2.151 ± 0.049
4.031AspArg: 4.031 ± 0.078
4.45AspSer: 4.45 ± 0.098
3.699AspThr: 3.699 ± 0.079
5.284AspVal: 5.284 ± 0.103
0.74AspTrp: 0.74 ± 0.032
1.618AspTyr: 1.618 ± 0.052
0.0AspXaa: 0.0 ± 0.0
Glu
5.861GluAla: 5.861 ± 0.108
0.418GluCys: 0.418 ± 0.025
3.393GluAsp: 3.393 ± 0.075
3.425GluGlu: 3.425 ± 0.089
1.747GluPhe: 1.747 ± 0.05
4.048GluGly: 4.048 ± 0.083
1.531GluHis: 1.531 ± 0.045
2.793GluIle: 2.793 ± 0.065
2.73GluLys: 2.73 ± 0.075
5.423GluLeu: 5.423 ± 0.104
1.206GluMet: 1.206 ± 0.045
1.895GluAsn: 1.895 ± 0.049
2.767GluPro: 2.767 ± 0.066
2.175GluGln: 2.175 ± 0.057
3.903GluArg: 3.903 ± 0.083
3.69GluSer: 3.69 ± 0.074
3.147GluThr: 3.147 ± 0.066
3.795GluVal: 3.795 ± 0.085
0.88GluTrp: 0.88 ± 0.036
1.292GluTyr: 1.292 ± 0.052
0.0GluXaa: 0.0 ± 0.0
Phe
3.309PheAla: 3.309 ± 0.072
0.274PheCys: 0.274 ± 0.02
2.122PheAsp: 2.122 ± 0.064
1.357PheGlu: 1.357 ± 0.045
1.171PhePhe: 1.171 ± 0.047
3.014PheGly: 3.014 ± 0.073
0.707PheHis: 0.707 ± 0.032
1.724PheIle: 1.724 ± 0.05
0.693PheLys: 0.693 ± 0.032
2.755PheLeu: 2.755 ± 0.076
0.662PheMet: 0.662 ± 0.028
0.94PheAsn: 0.94 ± 0.037
1.477PhePro: 1.477 ± 0.049
0.713PheGln: 0.713 ± 0.029
1.742PheArg: 1.742 ± 0.05
2.265PheSer: 2.265 ± 0.061
2.168PheThr: 2.168 ± 0.069
2.536PheVal: 2.536 ± 0.061
0.396PheTrp: 0.396 ± 0.025
0.761PheTyr: 0.761 ± 0.032
0.0PheXaa: 0.0 ± 0.0
Gly
8.087GlyAla: 8.087 ± 0.13
0.707GlyCys: 0.707 ± 0.032
5.026GlyAsp: 5.026 ± 0.088
4.416GlyGlu: 4.416 ± 0.089
2.929GlyPhe: 2.929 ± 0.065
6.799GlyGly: 6.799 ± 0.129
2.173GlyHis: 2.173 ± 0.056
4.605GlyIle: 4.605 ± 0.081
3.419GlyLys: 3.419 ± 0.076
7.588GlyLeu: 7.588 ± 0.122
2.188GlyMet: 2.188 ± 0.062
2.556GlyAsn: 2.556 ± 0.059
3.442GlyPro: 3.442 ± 0.074
2.8GlyGln: 2.8 ± 0.074
5.07GlyArg: 5.07 ± 0.089
6.066GlySer: 6.066 ± 0.108
5.387GlyThr: 5.387 ± 0.096
6.845GlyVal: 6.845 ± 0.115
1.374GlyTrp: 1.374 ± 0.046
2.134GlyTyr: 2.134 ± 0.055
0.0GlyXaa: 0.0 ± 0.0
His
2.441HisAla: 2.441 ± 0.063
0.234HisCys: 0.234 ± 0.018
1.843HisAsp: 1.843 ± 0.052
1.36HisGlu: 1.36 ± 0.044
0.658HisPhe: 0.658 ± 0.029
2.199HisGly: 2.199 ± 0.063
0.811HisHis: 0.811 ± 0.035
1.211HisIle: 1.211 ± 0.042
0.666HisLys: 0.666 ± 0.035
1.85HisLeu: 1.85 ± 0.055
0.519HisMet: 0.519 ± 0.024
0.808HisAsn: 0.808 ± 0.033
1.686HisPro: 1.686 ± 0.044
0.797HisGln: 0.797 ± 0.032
1.721HisArg: 1.721 ± 0.047
1.68HisSer: 1.68 ± 0.052
1.453HisThr: 1.453 ± 0.047
1.836HisVal: 1.836 ± 0.052
0.323HisTrp: 0.323 ± 0.023
0.597HisTyr: 0.597 ± 0.027
0.0HisXaa: 0.0 ± 0.0
Ile
6.286IleAla: 6.286 ± 0.106
0.434IleCys: 0.434 ± 0.022
3.965IleAsp: 3.965 ± 0.093
2.755IleGlu: 2.755 ± 0.073
1.518IlePhe: 1.518 ± 0.047
4.555IleGly: 4.555 ± 0.096
1.177IleHis: 1.177 ± 0.035
3.021IleIle: 3.021 ± 0.078
1.584IleLys: 1.584 ± 0.048
3.889IleLeu: 3.889 ± 0.087
1.136IleMet: 1.136 ± 0.042
1.713IleAsn: 1.713 ± 0.05
3.041IlePro: 3.041 ± 0.069
1.211IleGln: 1.211 ± 0.04
2.906IleArg: 2.906 ± 0.066
3.252IleSer: 3.252 ± 0.06
3.329IleThr: 3.329 ± 0.072
4.786IleVal: 4.786 ± 0.09
0.451IleTrp: 0.451 ± 0.028
0.985IleTyr: 0.985 ± 0.038
0.0IleXaa: 0.0 ± 0.0
Lys
3.709LysAla: 3.709 ± 0.101
0.143LysCys: 0.143 ± 0.014
2.541LysAsp: 2.541 ± 0.077
2.305LysGlu: 2.305 ± 0.064
0.785LysPhe: 0.785 ± 0.038
2.393LysGly: 2.393 ± 0.07
0.77LysHis: 0.77 ± 0.035
1.552LysIle: 1.552 ± 0.046
2.301LysLys: 2.301 ± 0.1
2.799LysLeu: 2.799 ± 0.075
0.855LysMet: 0.855 ± 0.034
1.429LysAsn: 1.429 ± 0.049
1.894LysPro: 1.894 ± 0.065
1.195LysGln: 1.195 ± 0.042
2.097LysArg: 2.097 ± 0.057
2.271LysSer: 2.271 ± 0.069
2.095LysThr: 2.095 ± 0.058
2.478LysVal: 2.478 ± 0.065
0.459LysTrp: 0.459 ± 0.027
0.828LysTyr: 0.828 ± 0.034
0.0LysXaa: 0.0 ± 0.0
Leu
9.901LeuAla: 9.901 ± 0.145
0.8LeuCys: 0.8 ± 0.034
5.597LeuAsp: 5.597 ± 0.102
4.004LeuGlu: 4.004 ± 0.081
2.79LeuPhe: 2.79 ± 0.08
7.31LeuGly: 7.31 ± 0.13
1.971LeuHis: 1.971 ± 0.059
4.843LeuIle: 4.843 ± 0.098
2.695LeuLys: 2.695 ± 0.07
7.283LeuLeu: 7.283 ± 0.132
1.775LeuMet: 1.775 ± 0.051
2.472LeuAsn: 2.472 ± 0.061
4.61LeuPro: 4.61 ± 0.087
2.312LeuGln: 2.312 ± 0.058
5.647LeuArg: 5.647 ± 0.103
6.1LeuSer: 6.1 ± 0.085
5.74LeuThr: 5.74 ± 0.089
6.954LeuVal: 6.954 ± 0.123
1.13LeuTrp: 1.13 ± 0.047
1.727LeuTyr: 1.727 ± 0.055
0.0LeuXaa: 0.0 ± 0.0
Met
2.572MetAla: 2.572 ± 0.068
0.22MetCys: 0.22 ± 0.017
1.133MetAsp: 1.133 ± 0.039
1.008MetGlu: 1.008 ± 0.039
0.661MetPhe: 0.661 ± 0.033
1.866MetGly: 1.866 ± 0.056
0.408MetHis: 0.408 ± 0.023
1.154MetIle: 1.154 ± 0.045
0.855MetLys: 0.855 ± 0.037
1.849MetLeu: 1.849 ± 0.053
0.533MetMet: 0.533 ± 0.029
0.834MetAsn: 0.834 ± 0.033
1.222MetPro: 1.222 ± 0.041
0.603MetGln: 0.603 ± 0.027
1.324MetArg: 1.324 ± 0.045
1.826MetSer: 1.826 ± 0.055
1.751MetThr: 1.751 ± 0.047
1.864MetVal: 1.864 ± 0.058
0.303MetTrp: 0.303 ± 0.024
0.43MetTyr: 0.43 ± 0.023
0.0MetXaa: 0.0 ± 0.0
Asn
3.227AsnAla: 3.227 ± 0.07
0.203AsnCys: 0.203 ± 0.016
2.25AsnAsp: 2.25 ± 0.065
1.593AsnGlu: 1.593 ± 0.043
0.852AsnPhe: 0.852 ± 0.034
2.685AsnGly: 2.685 ± 0.073
0.727AsnHis: 0.727 ± 0.032
1.415AsnIle: 1.415 ± 0.047
1.222AsnLys: 1.222 ± 0.047
2.419AsnLeu: 2.419 ± 0.059
0.629AsnMet: 0.629 ± 0.035
1.292AsnAsn: 1.292 ± 0.057
2.085AsnPro: 2.085 ± 0.05
1.09AsnGln: 1.09 ± 0.045
1.772AsnArg: 1.772 ± 0.048
2.214AsnSer: 2.214 ± 0.069
1.866AsnThr: 1.866 ± 0.056
2.172AsnVal: 2.172 ± 0.053
0.397AsnTrp: 0.397 ± 0.026
0.781AsnTyr: 0.781 ± 0.033
0.0AsnXaa: 0.0 ± 0.0
Pro
4.936ProAla: 4.936 ± 0.096
0.279ProCys: 0.279 ± 0.02
4.069ProAsp: 4.069 ± 0.091
3.763ProGlu: 3.763 ± 0.077
1.575ProPhe: 1.575 ± 0.046
4.402ProGly: 4.402 ± 0.089
1.469ProHis: 1.469 ± 0.048
2.394ProIle: 2.394 ± 0.059
1.541ProLys: 1.541 ± 0.051
4.169ProLeu: 4.169 ± 0.095
1.026ProMet: 1.026 ± 0.036
1.474ProAsn: 1.474 ± 0.05
1.932ProPro: 1.932 ± 0.063
1.81ProGln: 1.81 ± 0.057
3.023ProArg: 3.023 ± 0.073
3.892ProSer: 3.892 ± 0.079
3.598ProThr: 3.598 ± 0.089
4.053ProVal: 4.053 ± 0.079
0.797ProTrp: 0.797 ± 0.035
1.082ProTyr: 1.082 ± 0.042
0.0ProXaa: 0.0 ± 0.0
Gln
3.527GlnAla: 3.527 ± 0.073
0.2GlnCys: 0.2 ± 0.018
1.657GlnAsp: 1.657 ± 0.054
1.755GlnGlu: 1.755 ± 0.054
0.926GlnPhe: 0.926 ± 0.037
2.399GlnGly: 2.399 ± 0.063
0.831GlnHis: 0.831 ± 0.035
1.5GlnIle: 1.5 ± 0.041
1.157GlnLys: 1.157 ± 0.043
3.061GlnLeu: 3.061 ± 0.07
0.739GlnMet: 0.739 ± 0.036
0.951GlnAsn: 0.951 ± 0.044
1.795GlnPro: 1.795 ± 0.057
1.425GlnGln: 1.425 ± 0.059
2.482GlnArg: 2.482 ± 0.066
2.275GlnSer: 2.275 ± 0.065
1.572GlnThr: 1.572 ± 0.054
2.084GlnVal: 2.084 ± 0.055
0.618GlnTrp: 0.618 ± 0.027
0.692GlnTyr: 0.692 ± 0.033
0.0GlnXaa: 0.0 ± 0.0
Arg
6.198ArgAla: 6.198 ± 0.108
0.456ArgCys: 0.456 ± 0.028
3.999ArgAsp: 3.999 ± 0.08
3.928ArgGlu: 3.928 ± 0.079
2.023ArgPhe: 2.023 ± 0.049
4.798ArgGly: 4.798 ± 0.103
1.676ArgHis: 1.676 ± 0.053
3.271ArgIle: 3.271 ± 0.065
2.339ArgLys: 2.339 ± 0.061
5.156ArgLeu: 5.156 ± 0.1
1.582ArgMet: 1.582 ± 0.047
1.955ArgAsn: 1.955 ± 0.062
3.045ArgPro: 3.045 ± 0.071
2.146ArgGln: 2.146 ± 0.049
5.661ArgArg: 5.661 ± 0.123
4.114ArgSer: 4.114 ± 0.084
3.56ArgThr: 3.56 ± 0.072
4.454ArgVal: 4.454 ± 0.085
1.011ArgTrp: 1.011 ± 0.036
1.552ArgTyr: 1.552 ± 0.047
0.0ArgXaa: 0.0 ± 0.0
Ser
7.724SerAla: 7.724 ± 0.119
0.451SerCys: 0.451 ± 0.029
4.885SerAsp: 4.885 ± 0.094
3.757SerGlu: 3.757 ± 0.083
2.127SerPhe: 2.127 ± 0.065
6.55SerGly: 6.55 ± 0.118
1.786SerHis: 1.786 ± 0.055
3.066SerIle: 3.066 ± 0.065
1.982SerLys: 1.982 ± 0.059
5.797SerLeu: 5.797 ± 0.089
1.609SerMet: 1.609 ± 0.046
1.867SerAsn: 1.867 ± 0.062
3.527SerPro: 3.527 ± 0.076
2.26SerGln: 2.26 ± 0.062
4.186SerArg: 4.186 ± 0.091
6.571SerSer: 6.571 ± 0.154
5.046SerThr: 5.046 ± 0.088
5.285SerVal: 5.285 ± 0.087
0.984SerTrp: 0.984 ± 0.035
1.452SerTyr: 1.452 ± 0.04
0.0SerXaa: 0.0 ± 0.0
Thr
6.527ThrAla: 6.527 ± 0.109
0.462ThrCys: 0.462 ± 0.023
4.096ThrAsp: 4.096 ± 0.083
3.088ThrGlu: 3.088 ± 0.075
1.874ThrPhe: 1.874 ± 0.059
5.267ThrGly: 5.267 ± 0.081
1.513ThrHis: 1.513 ± 0.045
3.458ThrIle: 3.458 ± 0.06
1.972ThrLys: 1.972 ± 0.059
5.247ThrLeu: 5.247 ± 0.089
1.429ThrMet: 1.429 ± 0.044
1.927ThrAsn: 1.927 ± 0.055
4.134ThrPro: 4.134 ± 0.079
1.837ThrGln: 1.837 ± 0.059
3.377ThrArg: 3.377 ± 0.083
4.712ThrSer: 4.712 ± 0.095
4.62ThrThr: 4.62 ± 0.093
5.745ThrVal: 5.745 ± 0.101
0.838ThrTrp: 0.838 ± 0.037
1.392ThrTyr: 1.392 ± 0.05
0.0ThrXaa: 0.0 ± 0.0
Val
8.739ValAla: 8.739 ± 0.135
0.818ValCys: 0.818 ± 0.031
5.659ValAsp: 5.659 ± 0.099
4.384ValGlu: 4.384 ± 0.094
2.521ValPhe: 2.521 ± 0.066
6.425ValGly: 6.425 ± 0.115
1.792ValHis: 1.792 ± 0.05
4.739ValIle: 4.739 ± 0.093
2.48ValLys: 2.48 ± 0.067
7.013ValLeu: 7.013 ± 0.129
1.764ValMet: 1.764 ± 0.056
2.373ValAsn: 2.373 ± 0.063
3.923ValPro: 3.923 ± 0.073
1.975ValGln: 1.975 ± 0.054
4.467ValArg: 4.467 ± 0.087
5.355ValSer: 5.355 ± 0.088
5.193ValThr: 5.193 ± 0.09
7.371ValVal: 7.371 ± 0.12
1.029ValTrp: 1.029 ± 0.044
1.542ValTyr: 1.542 ± 0.049
0.0ValXaa: 0.0 ± 0.0
Trp
1.354TrpAla: 1.354 ± 0.048
0.14TrpCys: 0.14 ± 0.014
0.792TrpAsp: 0.792 ± 0.037
0.678TrpGlu: 0.678 ± 0.034
0.534TrpPhe: 0.534 ± 0.031
1.09TrpGly: 1.09 ± 0.045
0.293TrpHis: 0.293 ± 0.021
0.791TrpIle: 0.791 ± 0.034
0.526TrpLys: 0.526 ± 0.028
1.415TrpLeu: 1.415 ± 0.052
0.356TrpMet: 0.356 ± 0.023
0.485TrpAsn: 0.485 ± 0.032
0.605TrpPro: 0.605 ± 0.027
0.449TrpGln: 0.449 ± 0.027
0.899TrpArg: 0.899 ± 0.038
0.968TrpSer: 0.968 ± 0.04
0.835TrpThr: 0.835 ± 0.034
1.073TrpVal: 1.073 ± 0.041
0.356TrpTrp: 0.356 ± 0.019
0.289TrpTyr: 0.289 ± 0.02
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.2TyrAla: 2.2 ± 0.053
0.201TyrCys: 0.201 ± 0.014
1.503TyrAsp: 1.503 ± 0.049
1.204TyrGlu: 1.204 ± 0.043
0.791TyrPhe: 0.791 ± 0.034
2.047TyrGly: 2.047 ± 0.051
0.452TyrHis: 0.452 ± 0.025
0.978TyrIle: 0.978 ± 0.034
0.554TyrLys: 0.554 ± 0.029
2.0TyrLeu: 2.0 ± 0.056
0.431TyrMet: 0.431 ± 0.024
0.621TyrAsn: 0.621 ± 0.034
1.259TyrPro: 1.259 ± 0.045
0.715TyrGln: 0.715 ± 0.034
1.565TyrArg: 1.565 ± 0.045
1.555TyrSer: 1.555 ± 0.052
1.392TyrThr: 1.392 ± 0.042
1.609TyrVal: 1.609 ± 0.053
0.313TyrTrp: 0.313 ± 0.02
0.532TyrTyr: 0.532 ± 0.031
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2018 proteins (705368 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski