Amino acid dipepetide frequency for Pusillimonas thiosulfatoxidans

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	15.095AlaAla: 15.095 ± 0.173	1.2AlaCys: 1.2 ± 0.032	6.311AlaAsp: 6.311 ± 0.085	5.889AlaGlu: 5.889 ± 0.083	3.933AlaPhe: 3.933 ± 0.064	9.968AlaGly: 9.968 ± 0.116	2.368AlaHis: 2.368 ± 0.046	6.105AlaIle: 6.105 ± 0.072	3.339AlaLys: 3.339 ± 0.075	13.596AlaLeu: 13.596 ± 0.158	3.505AlaMet: 3.505 ± 0.06	2.896AlaAsn: 2.896 ± 0.056	4.97AlaPro: 4.97 ± 0.079	5.445AlaGln: 5.445 ± 0.082	7.646AlaArg: 7.646 ± 0.096	6.634AlaSer: 6.634 ± 0.081	5.898AlaThr: 5.898 ± 0.081	8.449AlaVal: 8.449 ± 0.099	1.752AlaTrp: 1.752 ± 0.04	2.849AlaTyr: 2.849 ± 0.055	0.0AlaXaa: 0.0 ± 0.0
Cys	1.064CysAla: 1.064 ± 0.037	0.13CysCys: 0.13 ± 0.011	0.492CysAsp: 0.492 ± 0.024	0.428CysGlu: 0.428 ± 0.018	0.323CysPhe: 0.323 ± 0.017	0.905CysGly: 0.905 ± 0.028	0.254CysHis: 0.254 ± 0.014	0.465CysIle: 0.465 ± 0.022	0.245CysLys: 0.245 ± 0.018	0.877CysLeu: 0.877 ± 0.029	0.251CysMet: 0.251 ± 0.013	0.246CysAsn: 0.246 ± 0.015	0.512CysPro: 0.512 ± 0.024	0.286CysGln: 0.286 ± 0.016	0.575CysArg: 0.575 ± 0.022	0.509CysSer: 0.509 ± 0.02	0.475CysThr: 0.475 ± 0.022	0.757CysVal: 0.757 ± 0.029	0.126CysTrp: 0.126 ± 0.01	0.222CysTyr: 0.222 ± 0.014	0.0CysXaa: 0.0 ± 0.0
Asp	6.351AspAla: 6.351 ± 0.081	0.492AspCys: 0.492 ± 0.021	3.022AspAsp: 3.022 ± 0.061	3.284AspGlu: 3.284 ± 0.067	2.065AspPhe: 2.065 ± 0.051	4.404AspGly: 4.404 ± 0.078	1.249AspHis: 1.249 ± 0.036	3.148AspIle: 3.148 ± 0.058	1.771AspLys: 1.771 ± 0.043	5.335AspLeu: 5.335 ± 0.081	1.411AspMet: 1.411 ± 0.037	1.361AspAsn: 1.361 ± 0.04	3.039AspPro: 3.039 ± 0.06	1.994AspGln: 1.994 ± 0.044	3.28AspArg: 3.28 ± 0.055	2.535AspSer: 2.535 ± 0.044	2.979AspThr: 2.979 ± 0.055	4.173AspVal: 4.173 ± 0.072	0.931AspTrp: 0.931 ± 0.036	1.614AspTyr: 1.614 ± 0.044	0.0AspXaa: 0.0 ± 0.0
Glu	6.132GluAla: 6.132 ± 0.087	0.381GluCys: 0.381 ± 0.018	2.403GluAsp: 2.403 ± 0.049	2.505GluGlu: 2.505 ± 0.061	1.771GluPhe: 1.771 ± 0.042	3.689GluGly: 3.689 ± 0.071	1.419GluHis: 1.419 ± 0.039	2.889GluIle: 2.889 ± 0.061	1.915GluLys: 1.915 ± 0.057	5.68GluLeu: 5.68 ± 0.087	1.246GluMet: 1.246 ± 0.037	1.491GluAsn: 1.491 ± 0.038	2.5GluPro: 2.5 ± 0.052	2.841GluGln: 2.841 ± 0.059	4.17GluArg: 4.17 ± 0.063	2.692GluSer: 2.692 ± 0.054	2.639GluThr: 2.639 ± 0.05	3.903GluVal: 3.903 ± 0.064	0.705GluTrp: 0.705 ± 0.027	1.194GluTyr: 1.194 ± 0.036	0.0GluXaa: 0.0 ± 0.0
Phe	3.774PheAla: 3.774 ± 0.064	0.339PheCys: 0.339 ± 0.016	2.386PheAsp: 2.386 ± 0.048	1.915PheGlu: 1.915 ± 0.043	1.477PhePhe: 1.477 ± 0.05	3.282PheGly: 3.282 ± 0.059	0.727PheHis: 0.727 ± 0.026	1.84PheIle: 1.84 ± 0.041	1.12PheLys: 1.12 ± 0.033	3.241PheLeu: 3.241 ± 0.061	0.966PheMet: 0.966 ± 0.032	1.218PheAsn: 1.218 ± 0.038	1.571PhePro: 1.571 ± 0.037	1.141PheGln: 1.141 ± 0.032	1.897PheArg: 1.897 ± 0.044	2.381PheSer: 2.381 ± 0.053	1.899PheThr: 1.899 ± 0.044	2.755PheVal: 2.755 ± 0.053	0.501PheTrp: 0.501 ± 0.024	0.974PheTyr: 0.974 ± 0.031	0.0PheXaa: 0.0 ± 0.0
Gly	8.321GlyAla: 8.321 ± 0.1	0.816GlyCys: 0.816 ± 0.03	3.903GlyAsp: 3.903 ± 0.073	3.854GlyGlu: 3.854 ± 0.065	3.131GlyPhe: 3.131 ± 0.062	6.348GlyGly: 6.348 ± 0.094	1.946GlyHis: 1.946 ± 0.049	4.611GlyIle: 4.611 ± 0.068	3.469GlyLys: 3.469 ± 0.066	8.975GlyLeu: 8.975 ± 0.11	2.533GlyMet: 2.533 ± 0.054	2.223GlyAsn: 2.223 ± 0.056	3.065GlyPro: 3.065 ± 0.05	3.302GlyGln: 3.302 ± 0.06	5.3GlyArg: 5.3 ± 0.075	4.819GlySer: 4.819 ± 0.061	4.36GlyThr: 4.36 ± 0.072	6.315GlyVal: 6.315 ± 0.087	1.305GlyTrp: 1.305 ± 0.037	2.462GlyTyr: 2.462 ± 0.049	0.0GlyXaa: 0.0 ± 0.0
His	2.753HisAla: 2.753 ± 0.056	0.282HisCys: 0.282 ± 0.018	1.306HisAsp: 1.306 ± 0.038	1.195HisGlu: 1.195 ± 0.031	0.838HisPhe: 0.838 ± 0.03	1.998HisGly: 1.998 ± 0.047	0.623HisHis: 0.623 ± 0.03	1.206HisIle: 1.206 ± 0.033	0.622HisLys: 0.622 ± 0.025	2.147HisLeu: 2.147 ± 0.044	0.537HisMet: 0.537 ± 0.025	0.595HisAsn: 0.595 ± 0.025	1.492HisPro: 1.492 ± 0.039	0.843HisGln: 0.843 ± 0.025	1.348HisArg: 1.348 ± 0.037	1.118HisSer: 1.118 ± 0.031	1.203HisThr: 1.203 ± 0.032	1.555HisVal: 1.555 ± 0.035	0.323HisTrp: 0.323 ± 0.018	0.657HisTyr: 0.657 ± 0.026	0.0HisXaa: 0.0 ± 0.0
Ile	6.609IleAla: 6.609 ± 0.084	0.448IleCys: 0.448 ± 0.02	3.327IleAsp: 3.327 ± 0.055	3.31IleGlu: 3.31 ± 0.059	1.713IlePhe: 1.713 ± 0.043	4.481IleGly: 4.481 ± 0.065	0.976IleHis: 0.976 ± 0.029	2.497IleIle: 2.497 ± 0.059	1.866IleLys: 1.866 ± 0.048	4.554IleLeu: 4.554 ± 0.07	1.194IleMet: 1.194 ± 0.033	1.723IleAsn: 1.723 ± 0.04	2.515IlePro: 2.515 ± 0.054	1.663IleGln: 1.663 ± 0.04	2.875IleArg: 2.875 ± 0.048	3.169IleSer: 3.169 ± 0.055	2.93IleThr: 2.93 ± 0.053	4.201IleVal: 4.201 ± 0.067	0.579IleTrp: 0.579 ± 0.028	1.192IleTyr: 1.192 ± 0.034	0.0IleXaa: 0.0 ± 0.0
Lys	3.793LysAla: 3.793 ± 0.079	0.158LysCys: 0.158 ± 0.013	1.551LysAsp: 1.551 ± 0.045	1.675LysGlu: 1.675 ± 0.044	0.871LysPhe: 0.871 ± 0.031	2.413LysGly: 2.413 ± 0.056	0.734LysHis: 0.734 ± 0.025	1.607LysIle: 1.607 ± 0.048	1.333LysLys: 1.333 ± 0.064	3.448LysLeu: 3.448 ± 0.06	0.866LysMet: 0.866 ± 0.03	0.954LysAsn: 0.954 ± 0.038	1.857LysPro: 1.857 ± 0.047	1.424LysGln: 1.424 ± 0.037	2.279LysArg: 2.279 ± 0.048	1.789LysSer: 1.789 ± 0.049	1.88LysThr: 1.88 ± 0.049	2.472LysVal: 2.472 ± 0.059	0.398LysTrp: 0.398 ± 0.023	0.676LysTyr: 0.676 ± 0.027	0.0LysXaa: 0.0 ± 0.0
Leu	14.147LeuAla: 14.147 ± 0.129	1.056LeuCys: 1.056 ± 0.034	6.124LeuAsp: 6.124 ± 0.085	5.311LeuGlu: 5.311 ± 0.087	3.7LeuPhe: 3.7 ± 0.066	8.559LeuGly: 8.559 ± 0.11	2.379LeuHis: 2.379 ± 0.051	5.354LeuIle: 5.354 ± 0.089	3.384LeuLys: 3.384 ± 0.062	11.142LeuLeu: 11.142 ± 0.131	2.675LeuMet: 2.675 ± 0.057	3.024LeuAsn: 3.024 ± 0.049	5.764LeuPro: 5.764 ± 0.076	4.111LeuGln: 4.111 ± 0.065	7.266LeuArg: 7.266 ± 0.099	6.506LeuSer: 6.506 ± 0.087	5.722LeuThr: 5.722 ± 0.071	7.607LeuVal: 7.607 ± 0.092	1.273LeuTrp: 1.273 ± 0.039	2.31LeuTyr: 2.31 ± 0.048	0.0LeuXaa: 0.0 ± 0.0
Met	3.141MetAla: 3.141 ± 0.05	0.176MetCys: 0.176 ± 0.014	1.211MetAsp: 1.211 ± 0.035	1.139MetGlu: 1.139 ± 0.033	0.795MetPhe: 0.795 ± 0.027	2.025MetGly: 2.025 ± 0.045	0.587MetHis: 0.587 ± 0.022	1.254MetIle: 1.254 ± 0.036	0.984MetLys: 0.984 ± 0.032	3.103MetLeu: 3.103 ± 0.056	0.7MetMet: 0.7 ± 0.031	0.883MetAsn: 0.883 ± 0.03	1.613MetPro: 1.613 ± 0.041	1.263MetGln: 1.263 ± 0.035	1.734MetArg: 1.734 ± 0.04	1.703MetSer: 1.703 ± 0.039	1.595MetThr: 1.595 ± 0.04	1.919MetVal: 1.919 ± 0.043	0.243MetTrp: 0.243 ± 0.016	0.457MetTyr: 0.457 ± 0.022	0.0MetXaa: 0.0 ± 0.0
Asn	3.185AsnAla: 3.185 ± 0.052	0.268AsnCys: 0.268 ± 0.018	1.506AsnAsp: 1.506 ± 0.041	1.501AsnGlu: 1.501 ± 0.037	0.989AsnPhe: 0.989 ± 0.032	2.249AsnGly: 2.249 ± 0.053	0.582AsnHis: 0.582 ± 0.022	1.603AsnIle: 1.603 ± 0.04	0.936AsnLys: 0.936 ± 0.033	2.846AsnLeu: 2.846 ± 0.055	0.736AsnMet: 0.736 ± 0.028	0.826AsnAsn: 0.826 ± 0.028	1.816AsnPro: 1.816 ± 0.05	1.001AsnGln: 1.001 ± 0.036	1.76AsnArg: 1.76 ± 0.045	1.38AsnSer: 1.38 ± 0.043	1.565AsnThr: 1.565 ± 0.039	1.996AsnVal: 1.996 ± 0.054	0.473AsnTrp: 0.473 ± 0.023	0.754AsnTyr: 0.754 ± 0.027	0.0AsnXaa: 0.0 ± 0.0
Pro	6.103ProAla: 6.103 ± 0.087	0.368ProCys: 0.368 ± 0.019	3.527ProAsp: 3.527 ± 0.054	3.407ProGlu: 3.407 ± 0.071	1.698ProPhe: 1.698 ± 0.038	4.144ProGly: 4.144 ± 0.064	1.013ProHis: 1.013 ± 0.029	2.253ProIle: 2.253 ± 0.048	1.376ProLys: 1.376 ± 0.042	4.954ProLeu: 4.954 ± 0.063	1.259ProMet: 1.259 ± 0.032	1.346ProAsn: 1.346 ± 0.037	2.278ProPro: 2.278 ± 0.054	2.076ProGln: 2.076 ± 0.045	2.603ProArg: 2.603 ± 0.048	2.818ProSer: 2.818 ± 0.055	2.65ProThr: 2.65 ± 0.051	4.231ProVal: 4.231 ± 0.069	0.76ProTrp: 0.76 ± 0.028	1.281ProTyr: 1.281 ± 0.038	0.0ProXaa: 0.0 ± 0.0
Gln	5.804GlnAla: 5.804 ± 0.098	0.297GlnCys: 0.297 ± 0.017	1.98GlnAsp: 1.98 ± 0.045	2.091GlnGlu: 2.091 ± 0.051	1.328GlnPhe: 1.328 ± 0.033	3.193GlnGly: 3.193 ± 0.053	1.117GlnHis: 1.117 ± 0.035	2.01GlnIle: 2.01 ± 0.048	1.172GlnLys: 1.172 ± 0.036	4.279GlnLeu: 4.279 ± 0.071	1.019GlnMet: 1.019 ± 0.034	1.016GlnAsn: 1.016 ± 0.03	2.065GlnPro: 2.065 ± 0.047	2.144GlnGln: 2.144 ± 0.051	3.122GlnArg: 3.122 ± 0.057	2.105GlnSer: 2.105 ± 0.05	2.113GlnThr: 2.113 ± 0.046	3.028GlnVal: 3.028 ± 0.054	0.667GlnTrp: 0.667 ± 0.025	0.974GlnTyr: 0.974 ± 0.031	0.0GlnXaa: 0.0 ± 0.0
Arg	6.484ArgAla: 6.484 ± 0.086	0.564ArgCys: 0.564 ± 0.024	3.465ArgAsp: 3.465 ± 0.061	3.591ArgGlu: 3.591 ± 0.063	2.356ArgPhe: 2.356 ± 0.047	4.258ArgGly: 4.258 ± 0.076	1.813ArgHis: 1.813 ± 0.039	3.65ArgIle: 3.65 ± 0.059	2.278ArgLys: 2.278 ± 0.049	7.43ArgLeu: 7.43 ± 0.099	1.803ArgMet: 1.803 ± 0.043	2.029ArgAsn: 2.029 ± 0.044	3.124ArgPro: 3.124 ± 0.062	2.988ArgGln: 2.988 ± 0.058	4.633ArgArg: 4.633 ± 0.084	3.831ArgSer: 3.831 ± 0.06	2.801ArgThr: 2.801 ± 0.045	4.667ArgVal: 4.667 ± 0.068	0.974ArgTrp: 0.974 ± 0.034	2.147ArgTyr: 2.147 ± 0.049	0.0ArgXaa: 0.0 ± 0.0
Ser	6.272SerAla: 6.272 ± 0.084	0.484SerCys: 0.484 ± 0.024	2.862SerAsp: 2.862 ± 0.053	2.666SerGlu: 2.666 ± 0.054	2.286SerPhe: 2.286 ± 0.048	5.395SerGly: 5.395 ± 0.077	1.245SerHis: 1.245 ± 0.033	2.995SerIle: 2.995 ± 0.061	1.648SerLys: 1.648 ± 0.045	6.244SerLeu: 6.244 ± 0.078	1.641SerMet: 1.641 ± 0.043	1.648SerAsn: 1.648 ± 0.036	2.787SerPro: 2.787 ± 0.048	2.116SerGln: 2.116 ± 0.045	3.716SerArg: 3.716 ± 0.058	3.498SerSer: 3.498 ± 0.062	3.087SerThr: 3.087 ± 0.057	4.244SerVal: 4.244 ± 0.066	0.857SerTrp: 0.857 ± 0.03	1.498SerTyr: 1.498 ± 0.042	0.0SerXaa: 0.0 ± 0.0
Thr	5.709ThrAla: 5.709 ± 0.085	0.447ThrCys: 0.447 ± 0.02	2.83ThrAsp: 2.83 ± 0.059	2.714ThrGlu: 2.714 ± 0.056	1.641ThrPhe: 1.641 ± 0.043	4.725ThrGly: 4.725 ± 0.076	1.151ThrHis: 1.151 ± 0.034	2.69ThrIle: 2.69 ± 0.058	1.276ThrLys: 1.276 ± 0.037	6.377ThrLeu: 6.377 ± 0.075	1.255ThrMet: 1.255 ± 0.036	1.261ThrAsn: 1.261 ± 0.033	3.393ThrPro: 3.393 ± 0.06	2.069ThrGln: 2.069 ± 0.048	3.172ThrArg: 3.172 ± 0.057	2.888ThrSer: 2.888 ± 0.057	2.844ThrThr: 2.844 ± 0.057	4.386ThrVal: 4.386 ± 0.06	0.692ThrTrp: 0.692 ± 0.024	1.153ThrTyr: 1.153 ± 0.04	0.0ThrXaa: 0.0 ± 0.0
Val	9.037ValAla: 9.037 ± 0.101	0.784ValCys: 0.784 ± 0.027	4.148ValAsp: 4.148 ± 0.063	3.795ValGlu: 3.795 ± 0.064	2.921ValPhe: 2.921 ± 0.048	5.758ValGly: 5.758 ± 0.094	1.614ValHis: 1.614 ± 0.043	3.867ValIle: 3.867 ± 0.074	2.26ValLys: 2.26 ± 0.053	8.551ValLeu: 8.551 ± 0.098	1.932ValMet: 1.932 ± 0.046	2.173ValAsn: 2.173 ± 0.045	3.811ValPro: 3.811 ± 0.067	3.051ValGln: 3.051 ± 0.05	4.517ValArg: 4.517 ± 0.069	4.641ValSer: 4.641 ± 0.071	3.869ValThr: 3.869 ± 0.065	6.155ValVal: 6.155 ± 0.091	0.999ValTrp: 0.999 ± 0.03	1.731ValTyr: 1.731 ± 0.045	0.0ValXaa: 0.0 ± 0.0
Trp	1.306TrpAla: 1.306 ± 0.038	0.148TrpCys: 0.148 ± 0.011	0.622TrpAsp: 0.622 ± 0.026	0.561TrpGlu: 0.561 ± 0.024	0.575TrpPhe: 0.575 ± 0.024	0.903TrpGly: 0.903 ± 0.028	0.368TrpHis: 0.368 ± 0.018	0.722TrpIle: 0.722 ± 0.027	0.449TrpLys: 0.449 ± 0.023	2.089TrpLeu: 2.089 ± 0.047	0.422TrpMet: 0.422 ± 0.022	0.434TrpAsn: 0.434 ± 0.021	0.677TrpPro: 0.677 ± 0.026	0.767TrpGln: 0.767 ± 0.021	1.176TrpArg: 1.176 ± 0.033	0.783TrpSer: 0.783 ± 0.029	0.689TrpThr: 0.689 ± 0.027	0.954TrpVal: 0.954 ± 0.032	0.275TrpTrp: 0.275 ± 0.016	0.325TrpTyr: 0.325 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.773TyrAla: 2.773 ± 0.056	0.301TyrCys: 0.301 ± 0.018	1.46TyrAsp: 1.46 ± 0.041	1.335TyrGlu: 1.335 ± 0.037	0.988TyrPhe: 0.988 ± 0.036	2.362TyrGly: 2.362 ± 0.056	0.472TyrHis: 0.472 ± 0.019	1.058TyrIle: 1.058 ± 0.033	0.736TyrLys: 0.736 ± 0.025	2.547TyrLeu: 2.547 ± 0.048	0.572TyrMet: 0.572 ± 0.025	0.626TyrAsn: 0.626 ± 0.026	1.297TyrPro: 1.297 ± 0.04	1.001TyrGln: 1.001 ± 0.029	1.816TyrArg: 1.816 ± 0.043	1.392TyrSer: 1.392 ± 0.037	1.475TyrThr: 1.475 ± 0.041	1.844TyrVal: 1.844 ± 0.039	0.412TyrTrp: 0.412 ± 0.021	0.653TyrTyr: 0.653 ± 0.029	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3284 proteins (1077498 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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