Amino acid dipepetide frequency for Streptococcus satellite phage Javan728

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
1.033AlaAla: 1.033 ± 0.482
0.774AlaCys: 0.774 ± 0.545
2.839AlaAsp: 2.839 ± 0.798
6.195AlaGlu: 6.195 ± 1.055
2.839AlaPhe: 2.839 ± 0.835
2.839AlaGly: 2.839 ± 0.675
0.0AlaHis: 0.0 ± 0.0
4.904AlaIle: 4.904 ± 1.05
4.388AlaLys: 4.388 ± 0.762
5.163AlaLeu: 5.163 ± 1.194
1.807AlaMet: 1.807 ± 0.76
2.839AlaAsn: 2.839 ± 0.735
1.549AlaPro: 1.549 ± 0.685
2.065AlaGln: 2.065 ± 0.787
4.388AlaArg: 4.388 ± 1.108
2.323AlaSer: 2.323 ± 0.76
4.13AlaThr: 4.13 ± 0.981
3.098AlaVal: 3.098 ± 0.593
0.516AlaTrp: 0.516 ± 0.344
1.807AlaTyr: 1.807 ± 0.48
0.0AlaXaa: 0.0 ± 0.0
Cys
0.516CysAla: 0.516 ± 0.298
0.0CysCys: 0.0 ± 0.0
0.774CysAsp: 0.774 ± 0.412
0.0CysGlu: 0.0 ± 0.0
0.258CysPhe: 0.258 ± 0.245
0.774CysGly: 0.774 ± 0.551
0.258CysHis: 0.258 ± 0.228
0.0CysIle: 0.0 ± 0.0
0.774CysLys: 0.774 ± 0.42
1.549CysLeu: 1.549 ± 0.625
0.258CysMet: 0.258 ± 0.224
0.516CysAsn: 0.516 ± 0.445
0.516CysPro: 0.516 ± 0.327
0.516CysGln: 0.516 ± 0.362
0.774CysArg: 0.774 ± 0.43
0.0CysSer: 0.0 ± 0.0
0.0CysThr: 0.0 ± 0.0
0.516CysVal: 0.516 ± 0.344
0.0CysTrp: 0.0 ± 0.0
0.516CysTyr: 0.516 ± 0.311
0.0CysXaa: 0.0 ± 0.0
Asp
0.774AspAla: 0.774 ± 0.433
0.774AspCys: 0.774 ± 0.554
3.356AspAsp: 3.356 ± 0.89
4.646AspGlu: 4.646 ± 1.142
4.388AspPhe: 4.388 ± 1.185
3.098AspGly: 3.098 ± 0.812
0.258AspHis: 0.258 ± 0.296
5.679AspIle: 5.679 ± 1.247
5.163AspLys: 5.163 ± 0.924
6.711AspLeu: 6.711 ± 1.539
1.549AspMet: 1.549 ± 0.576
2.839AspAsn: 2.839 ± 1.005
0.774AspPro: 0.774 ± 0.383
0.516AspGln: 0.516 ± 0.381
3.098AspArg: 3.098 ± 0.872
1.807AspSer: 1.807 ± 0.638
3.356AspThr: 3.356 ± 0.797
2.839AspVal: 2.839 ± 0.889
0.774AspTrp: 0.774 ± 0.387
3.872AspTyr: 3.872 ± 1.193
0.0AspXaa: 0.0 ± 0.0
Glu
4.646GluAla: 4.646 ± 1.24
1.033GluCys: 1.033 ± 0.403
3.872GluAsp: 3.872 ± 1.132
5.937GluGlu: 5.937 ± 1.161
2.581GluPhe: 2.581 ± 0.883
2.839GluGly: 2.839 ± 0.772
2.323GluHis: 2.323 ± 0.69
6.453GluIle: 6.453 ± 1.127
7.486GluLys: 7.486 ± 1.133
11.1GluLeu: 11.1 ± 1.995
2.581GluMet: 2.581 ± 0.658
6.195GluAsn: 6.195 ± 1.338
2.581GluPro: 2.581 ± 0.856
3.614GluGln: 3.614 ± 0.88
5.421GluArg: 5.421 ± 1.063
5.937GluSer: 5.937 ± 1.195
4.388GluThr: 4.388 ± 0.853
3.872GluVal: 3.872 ± 0.84
1.033GluTrp: 1.033 ± 0.49
4.13GluTyr: 4.13 ± 0.873
0.0GluXaa: 0.0 ± 0.0
Phe
1.549PheAla: 1.549 ± 0.683
0.258PheCys: 0.258 ± 0.251
3.614PheAsp: 3.614 ± 0.877
3.098PheGlu: 3.098 ± 0.905
1.807PhePhe: 1.807 ± 0.936
1.807PheGly: 1.807 ± 0.61
0.516PheHis: 0.516 ± 0.288
2.323PheIle: 2.323 ± 0.641
4.388PheLys: 4.388 ± 1.007
5.163PheLeu: 5.163 ± 1.168
0.516PheMet: 0.516 ± 0.338
3.614PheAsn: 3.614 ± 0.858
1.033PhePro: 1.033 ± 0.429
2.065PheGln: 2.065 ± 0.598
1.291PheArg: 1.291 ± 0.472
2.581PheSer: 2.581 ± 0.51
2.323PheThr: 2.323 ± 0.698
0.516PheVal: 0.516 ± 0.336
0.774PheTrp: 0.774 ± 0.388
2.065PheTyr: 2.065 ± 0.581
0.0PheXaa: 0.0 ± 0.0
Gly
2.839GlyAla: 2.839 ± 0.838
0.258GlyCys: 0.258 ± 0.228
2.581GlyAsp: 2.581 ± 0.893
4.13GlyGlu: 4.13 ± 1.11
1.807GlyPhe: 1.807 ± 0.659
2.839GlyGly: 2.839 ± 0.955
1.033GlyHis: 1.033 ± 0.505
5.163GlyIle: 5.163 ± 1.119
4.388GlyLys: 4.388 ± 1.155
6.195GlyLeu: 6.195 ± 1.049
1.033GlyMet: 1.033 ± 0.529
2.323GlyAsn: 2.323 ± 0.852
0.258GlyPro: 0.258 ± 0.228
1.549GlyGln: 1.549 ± 0.475
3.872GlyArg: 3.872 ± 0.867
1.807GlySer: 1.807 ± 0.551
3.356GlyThr: 3.356 ± 0.94
3.872GlyVal: 3.872 ± 1.21
0.774GlyTrp: 0.774 ± 0.461
2.839GlyTyr: 2.839 ± 0.852
0.0GlyXaa: 0.0 ± 0.0
His
1.807HisAla: 1.807 ± 0.751
0.0HisCys: 0.0 ± 0.0
1.033HisAsp: 1.033 ± 0.471
0.774HisGlu: 0.774 ± 0.472
1.291HisPhe: 1.291 ± 0.634
1.291HisGly: 1.291 ± 0.748
0.258HisHis: 0.258 ± 0.251
0.774HisIle: 0.774 ± 0.49
0.774HisLys: 0.774 ± 0.631
1.033HisLeu: 1.033 ± 0.495
0.258HisMet: 0.258 ± 0.279
1.291HisAsn: 1.291 ± 0.778
0.258HisPro: 0.258 ± 0.276
0.774HisGln: 0.774 ± 0.372
0.774HisArg: 0.774 ± 0.46
0.774HisSer: 0.774 ± 0.381
1.291HisThr: 1.291 ± 0.571
0.0HisVal: 0.0 ± 0.0
0.0HisTrp: 0.0 ± 0.0
1.291HisTyr: 1.291 ± 0.499
0.0HisXaa: 0.0 ± 0.0
Ile
5.163IleAla: 5.163 ± 1.015
0.258IleCys: 0.258 ± 0.257
6.195IleAsp: 6.195 ± 1.991
6.711IleGlu: 6.711 ± 1.805
4.13IlePhe: 4.13 ± 0.866
2.839IleGly: 2.839 ± 0.737
1.033IleHis: 1.033 ± 0.546
4.646IleIle: 4.646 ± 0.905
6.97IleLys: 6.97 ± 1.35
3.098IleLeu: 3.098 ± 0.625
0.774IleMet: 0.774 ± 0.384
2.581IleAsn: 2.581 ± 0.945
3.614IlePro: 3.614 ± 0.802
2.581IleGln: 2.581 ± 0.743
3.356IleArg: 3.356 ± 0.833
4.388IleSer: 4.388 ± 0.836
3.098IleThr: 3.098 ± 0.674
3.098IleVal: 3.098 ± 0.703
0.258IleTrp: 0.258 ± 0.227
2.839IleTyr: 2.839 ± 0.747
0.0IleXaa: 0.0 ± 0.0
Lys
7.486LysAla: 7.486 ± 1.339
0.258LysCys: 0.258 ± 0.245
2.839LysAsp: 2.839 ± 0.746
8.26LysGlu: 8.26 ± 1.385
2.581LysPhe: 2.581 ± 0.82
5.679LysGly: 5.679 ± 0.957
4.13LysHis: 4.13 ± 0.826
4.13LysIle: 4.13 ± 0.759
6.97LysLys: 6.97 ± 1.67
8.26LysLeu: 8.26 ± 1.603
2.323LysMet: 2.323 ± 0.858
5.937LysAsn: 5.937 ± 1.012
3.098LysPro: 3.098 ± 1.217
4.13LysGln: 4.13 ± 0.834
6.195LysArg: 6.195 ± 1.137
6.195LysSer: 6.195 ± 0.942
6.711LysThr: 6.711 ± 1.296
4.904LysVal: 4.904 ± 0.714
1.291LysTrp: 1.291 ± 0.507
2.839LysTyr: 2.839 ± 0.8
0.0LysXaa: 0.0 ± 0.0
Leu
5.679LeuAla: 5.679 ± 1.216
1.291LeuCys: 1.291 ± 0.417
9.551LeuAsp: 9.551 ± 1.394
11.616LeuGlu: 11.616 ± 1.652
3.614LeuPhe: 3.614 ± 1.016
4.904LeuGly: 4.904 ± 0.93
0.774LeuHis: 0.774 ± 0.444
5.421LeuIle: 5.421 ± 1.211
9.293LeuLys: 9.293 ± 1.507
8.776LeuLeu: 8.776 ± 1.394
2.065LeuMet: 2.065 ± 0.623
6.453LeuAsn: 6.453 ± 1.275
3.356LeuPro: 3.356 ± 0.967
3.356LeuGln: 3.356 ± 0.877
3.098LeuArg: 3.098 ± 0.86
5.679LeuSer: 5.679 ± 0.853
7.744LeuThr: 7.744 ± 0.97
4.904LeuVal: 4.904 ± 0.916
0.258LeuTrp: 0.258 ± 0.288
4.646LeuTyr: 4.646 ± 0.727
0.0LeuXaa: 0.0 ± 0.0
Met
2.065MetAla: 2.065 ± 0.711
0.0MetCys: 0.0 ± 0.0
1.291MetAsp: 1.291 ± 0.47
3.356MetGlu: 3.356 ± 0.715
0.516MetPhe: 0.516 ± 0.378
2.065MetGly: 2.065 ± 0.658
0.0MetHis: 0.0 ± 0.0
1.549MetIle: 1.549 ± 0.488
2.581MetLys: 2.581 ± 0.835
1.291MetLeu: 1.291 ± 0.557
0.774MetMet: 0.774 ± 0.436
2.065MetAsn: 2.065 ± 0.747
0.516MetPro: 0.516 ± 0.336
0.774MetGln: 0.774 ± 0.385
2.323MetArg: 2.323 ± 0.829
1.291MetSer: 1.291 ± 0.48
3.356MetThr: 3.356 ± 1.21
0.516MetVal: 0.516 ± 0.331
0.0MetTrp: 0.0 ± 0.0
0.0MetTyr: 0.0 ± 0.0
0.0MetXaa: 0.0 ± 0.0
Asn
1.807AsnAla: 1.807 ± 0.667
0.0AsnCys: 0.0 ± 0.0
3.098AsnAsp: 3.098 ± 0.872
2.839AsnGlu: 2.839 ± 0.714
1.807AsnPhe: 1.807 ± 0.752
5.163AsnGly: 5.163 ± 0.907
1.033AsnHis: 1.033 ± 0.545
3.614AsnIle: 3.614 ± 1.112
6.453AsnLys: 6.453 ± 0.775
5.937AsnLeu: 5.937 ± 1.223
1.807AsnMet: 1.807 ± 0.812
2.581AsnAsn: 2.581 ± 0.718
3.098AsnPro: 3.098 ± 0.708
2.323AsnGln: 2.323 ± 0.709
1.549AsnArg: 1.549 ± 0.458
3.356AsnSer: 3.356 ± 0.583
2.839AsnThr: 2.839 ± 0.885
1.807AsnVal: 1.807 ± 0.596
0.258AsnTrp: 0.258 ± 0.228
2.065AsnTyr: 2.065 ± 0.607
0.0AsnXaa: 0.0 ± 0.0
Pro
2.323ProAla: 2.323 ± 0.593
0.0ProCys: 0.0 ± 0.0
1.807ProAsp: 1.807 ± 0.817
2.839ProGlu: 2.839 ± 0.839
2.065ProPhe: 2.065 ± 0.932
0.774ProGly: 0.774 ± 0.631
0.0ProHis: 0.0 ± 0.0
1.549ProIle: 1.549 ± 0.474
3.872ProLys: 3.872 ± 1.145
1.549ProLeu: 1.549 ± 0.59
1.291ProMet: 1.291 ± 0.485
2.065ProAsn: 2.065 ± 0.878
1.549ProPro: 1.549 ± 0.631
1.291ProGln: 1.291 ± 0.545
4.13ProArg: 4.13 ± 0.914
1.033ProSer: 1.033 ± 0.453
1.291ProThr: 1.291 ± 0.471
1.807ProVal: 1.807 ± 0.657
0.258ProTrp: 0.258 ± 0.222
1.291ProTyr: 1.291 ± 0.419
0.0ProXaa: 0.0 ± 0.0
Gln
3.098GlnAla: 3.098 ± 1.022
0.258GlnCys: 0.258 ± 0.251
1.291GlnAsp: 1.291 ± 0.489
3.614GlnGlu: 3.614 ± 0.973
0.516GlnPhe: 0.516 ± 0.354
2.323GlnGly: 2.323 ± 0.852
0.0GlnHis: 0.0 ± 0.0
2.065GlnIle: 2.065 ± 0.605
4.13GlnLys: 4.13 ± 0.825
4.904GlnLeu: 4.904 ± 0.94
0.774GlnMet: 0.774 ± 0.488
1.033GlnAsn: 1.033 ± 0.476
1.033GlnPro: 1.033 ± 0.603
1.549GlnGln: 1.549 ± 0.612
2.065GlnArg: 2.065 ± 0.714
1.291GlnSer: 1.291 ± 0.474
2.581GlnThr: 2.581 ± 0.652
2.839GlnVal: 2.839 ± 0.806
0.516GlnTrp: 0.516 ± 0.296
1.033GlnTyr: 1.033 ± 0.486
0.0GlnXaa: 0.0 ± 0.0
Arg
3.872ArgAla: 3.872 ± 1.071
0.516ArgCys: 0.516 ± 0.342
2.323ArgAsp: 2.323 ± 0.779
5.421ArgGlu: 5.421 ± 0.969
3.098ArgPhe: 3.098 ± 0.831
3.872ArgGly: 3.872 ± 0.917
0.516ArgHis: 0.516 ± 0.288
5.421ArgIle: 5.421 ± 0.918
3.872ArgLys: 3.872 ± 0.869
6.97ArgLeu: 6.97 ± 1.336
1.549ArgMet: 1.549 ± 0.692
2.323ArgAsn: 2.323 ± 0.919
1.291ArgPro: 1.291 ± 0.481
2.323ArgGln: 2.323 ± 0.736
2.323ArgArg: 2.323 ± 0.891
1.291ArgSer: 1.291 ± 0.477
2.839ArgThr: 2.839 ± 0.743
2.065ArgVal: 2.065 ± 0.729
0.0ArgTrp: 0.0 ± 0.0
3.356ArgTyr: 3.356 ± 1.252
0.0ArgXaa: 0.0 ± 0.0
Ser
2.581SerAla: 2.581 ± 0.739
0.774SerCys: 0.774 ± 0.492
2.839SerAsp: 2.839 ± 0.783
5.163SerGlu: 5.163 ± 0.905
1.549SerPhe: 1.549 ± 0.754
3.098SerGly: 3.098 ± 0.615
0.774SerHis: 0.774 ± 0.413
4.646SerIle: 4.646 ± 0.762
5.163SerLys: 5.163 ± 0.891
5.421SerLeu: 5.421 ± 0.955
1.549SerMet: 1.549 ± 0.569
3.356SerAsn: 3.356 ± 1.071
1.549SerPro: 1.549 ± 0.495
1.807SerGln: 1.807 ± 0.652
1.549SerArg: 1.549 ± 0.858
2.323SerSer: 2.323 ± 0.921
2.065SerThr: 2.065 ± 0.632
1.807SerVal: 1.807 ± 0.655
0.516SerTrp: 0.516 ± 0.324
1.807SerTyr: 1.807 ± 0.721
0.0SerXaa: 0.0 ± 0.0
Thr
2.323ThrAla: 2.323 ± 0.687
0.516ThrCys: 0.516 ± 0.357
2.323ThrAsp: 2.323 ± 0.67
4.13ThrGlu: 4.13 ± 0.796
3.356ThrPhe: 3.356 ± 1.413
2.839ThrGly: 2.839 ± 0.789
1.291ThrHis: 1.291 ± 0.471
3.872ThrIle: 3.872 ± 0.99
6.195ThrLys: 6.195 ± 1.188
6.97ThrLeu: 6.97 ± 0.894
2.323ThrMet: 2.323 ± 0.759
1.033ThrAsn: 1.033 ± 0.539
2.581ThrPro: 2.581 ± 0.966
1.807ThrGln: 1.807 ± 0.649
2.581ThrArg: 2.581 ± 0.874
2.839ThrSer: 2.839 ± 0.76
4.388ThrThr: 4.388 ± 0.996
4.13ThrVal: 4.13 ± 1.337
0.774ThrTrp: 0.774 ± 0.428
4.904ThrTyr: 4.904 ± 1.175
0.0ThrXaa: 0.0 ± 0.0
Val
3.356ValAla: 3.356 ± 1.229
0.516ValCys: 0.516 ± 0.319
2.065ValAsp: 2.065 ± 0.726
5.937ValGlu: 5.937 ± 1.299
1.033ValPhe: 1.033 ± 0.478
1.807ValGly: 1.807 ± 0.756
0.258ValHis: 0.258 ± 0.287
1.807ValIle: 1.807 ± 0.628
5.163ValLys: 5.163 ± 1.075
5.163ValLeu: 5.163 ± 0.978
1.291ValMet: 1.291 ± 0.754
2.839ValAsn: 2.839 ± 0.745
2.065ValPro: 2.065 ± 0.751
1.291ValGln: 1.291 ± 0.454
2.581ValArg: 2.581 ± 1.0
1.807ValSer: 1.807 ± 0.833
3.098ValThr: 3.098 ± 0.817
3.356ValVal: 3.356 ± 0.977
0.258ValTrp: 0.258 ± 0.306
2.323ValTyr: 2.323 ± 0.717
0.0ValXaa: 0.0 ± 0.0
Trp
0.258TrpAla: 0.258 ± 0.228
0.0TrpCys: 0.0 ± 0.0
0.0TrpAsp: 0.0 ± 0.0
1.033TrpGlu: 1.033 ± 0.476
0.0TrpPhe: 0.0 ± 0.0
0.516TrpGly: 0.516 ± 0.377
0.258TrpHis: 0.258 ± 0.222
1.291TrpIle: 1.291 ± 0.491
0.516TrpLys: 0.516 ± 0.344
1.033TrpLeu: 1.033 ± 0.377
0.0TrpMet: 0.0 ± 0.0
0.0TrpAsn: 0.0 ± 0.0
0.258TrpPro: 0.258 ± 0.222
0.516TrpGln: 0.516 ± 0.326
0.516TrpArg: 0.516 ± 0.332
1.033TrpSer: 1.033 ± 0.444
0.0TrpThr: 0.0 ± 0.0
0.774TrpVal: 0.774 ± 0.337
0.0TrpTrp: 0.0 ± 0.0
0.516TrpTyr: 0.516 ± 0.332
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.323TyrAla: 2.323 ± 0.726
1.033TyrCys: 1.033 ± 0.382
2.581TyrAsp: 2.581 ± 0.698
2.323TyrGlu: 2.323 ± 0.779
2.065TyrPhe: 2.065 ± 0.726
1.549TyrGly: 1.549 ± 0.759
1.033TyrHis: 1.033 ± 0.443
2.323TyrIle: 2.323 ± 0.745
5.679TyrLys: 5.679 ± 1.362
6.195TyrLeu: 6.195 ± 1.233
1.549TyrMet: 1.549 ± 0.605
1.549TyrAsn: 1.549 ± 0.586
1.807TyrPro: 1.807 ± 0.852
2.065TyrGln: 2.065 ± 0.585
3.356TyrArg: 3.356 ± 0.69
2.581TyrSer: 2.581 ± 0.81
2.323TyrThr: 2.323 ± 0.625
1.549TyrVal: 1.549 ± 0.639
0.258TyrTrp: 0.258 ± 0.255
0.516TyrTyr: 0.516 ± 0.362
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 27 proteins (3875 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski