Amino acid dipepetide frequency for Cylindrospermum stagnale PCC 7417

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	7.583AlaAla: 7.583 ± 0.086	0.787AlaCys: 0.787 ± 0.022	4.202AlaAsp: 4.202 ± 0.048	5.326AlaGlu: 5.326 ± 0.054	2.94AlaPhe: 2.94 ± 0.043	5.271AlaGly: 5.271 ± 0.073	1.223AlaHis: 1.223 ± 0.027	6.73AlaIle: 6.73 ± 0.075	4.394AlaLys: 4.394 ± 0.049	8.498AlaLeu: 8.498 ± 0.09	1.545AlaMet: 1.545 ± 0.028	3.568AlaAsn: 3.568 ± 0.065	2.898AlaPro: 2.898 ± 0.039	3.985AlaGln: 3.985 ± 0.053	3.366AlaArg: 3.366 ± 0.056	4.862AlaSer: 4.862 ± 0.057	4.649AlaThr: 4.649 ± 0.06	5.582AlaVal: 5.582 ± 0.06	1.035AlaTrp: 1.035 ± 0.026	2.354AlaTyr: 2.354 ± 0.043	0.0AlaXaa: 0.0 ± 0.0
Cys	0.62CysAla: 0.62 ± 0.018	0.179CysCys: 0.179 ± 0.009	0.524CysAsp: 0.524 ± 0.015	0.505CysGlu: 0.505 ± 0.017	0.433CysPhe: 0.433 ± 0.014	0.775CysGly: 0.775 ± 0.02	0.281CysHis: 0.281 ± 0.011	0.602CysIle: 0.602 ± 0.02	0.377CysLys: 0.377 ± 0.014	1.184CysLeu: 1.184 ± 0.028	0.146CysMet: 0.146 ± 0.009	0.384CysAsn: 0.384 ± 0.016	0.527CysPro: 0.527 ± 0.02	0.627CysGln: 0.627 ± 0.019	0.515CysArg: 0.515 ± 0.016	0.63CysSer: 0.63 ± 0.017	0.457CysThr: 0.457 ± 0.015	0.56CysVal: 0.56 ± 0.018	0.149CysTrp: 0.149 ± 0.009	0.391CysTyr: 0.391 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	3.762AspAla: 3.762 ± 0.048	0.527AspCys: 0.527 ± 0.016	2.246AspAsp: 2.246 ± 0.045	2.991AspGlu: 2.991 ± 0.042	2.382AspPhe: 2.382 ± 0.042	3.207AspGly: 3.207 ± 0.049	0.742AspHis: 0.742 ± 0.022	3.594AspIle: 3.594 ± 0.052	2.525AspLys: 2.525 ± 0.045	5.615AspLeu: 5.615 ± 0.061	0.763AspMet: 0.763 ± 0.019	2.128AspAsn: 2.128 ± 0.033	2.097AspPro: 2.097 ± 0.035	1.876AspGln: 1.876 ± 0.031	2.732AspArg: 2.732 ± 0.041	3.084AspSer: 3.084 ± 0.044	2.434AspThr: 2.434 ± 0.05	2.961AspVal: 2.961 ± 0.045	0.908AspTrp: 0.908 ± 0.02	1.882AspTyr: 1.882 ± 0.034	0.0AspXaa: 0.0 ± 0.0
Glu	5.338GluAla: 5.338 ± 0.061	0.517GluCys: 0.517 ± 0.016	2.715GluAsp: 2.715 ± 0.043	4.163GluGlu: 4.163 ± 0.064	2.523GluPhe: 2.523 ± 0.037	3.057GluGly: 3.057 ± 0.043	0.972GluHis: 0.972 ± 0.021	5.082GluIle: 5.082 ± 0.058	3.795GluLys: 3.795 ± 0.048	7.177GluLeu: 7.177 ± 0.073	1.281GluMet: 1.281 ± 0.027	2.983GluAsn: 2.983 ± 0.044	2.408GluPro: 2.408 ± 0.036	3.531GluGln: 3.531 ± 0.044	3.323GluArg: 3.323 ± 0.049	3.51GluSer: 3.51 ± 0.051	3.512GluThr: 3.512 ± 0.041	4.295GluVal: 4.295 ± 0.05	0.796GluTrp: 0.796 ± 0.021	1.954GluTyr: 1.954 ± 0.034	0.0GluXaa: 0.0 ± 0.0
Phe	3.139PheAla: 3.139 ± 0.049	0.558PheCys: 0.558 ± 0.017	2.227PheAsp: 2.227 ± 0.04	2.177PheGlu: 2.177 ± 0.037	1.735PhePhe: 1.735 ± 0.035	2.816PheGly: 2.816 ± 0.042	0.731PheHis: 0.731 ± 0.019	2.435PheIle: 2.435 ± 0.04	1.662PheLys: 1.662 ± 0.032	4.168PheLeu: 4.168 ± 0.052	0.678PheMet: 0.678 ± 0.019	1.865PheAsn: 1.865 ± 0.037	1.78PhePro: 1.78 ± 0.029	1.856PheGln: 1.856 ± 0.035	1.77PheArg: 1.77 ± 0.029	3.038PheSer: 3.038 ± 0.048	2.38PheThr: 2.38 ± 0.041	2.455PheVal: 2.455 ± 0.038	0.703PheTrp: 0.703 ± 0.02	1.414PheTyr: 1.414 ± 0.027	0.0PheXaa: 0.0 ± 0.0
Gly	4.719GlyAla: 4.719 ± 0.064	0.754GlyCys: 0.754 ± 0.019	3.284GlyAsp: 3.284 ± 0.047	4.059GlyGlu: 4.059 ± 0.046	2.862GlyPhe: 2.862 ± 0.04	4.642GlyGly: 4.642 ± 0.071	1.154GlyHis: 1.154 ± 0.03	4.931GlyIle: 4.931 ± 0.051	4.182GlyLys: 4.182 ± 0.055	6.697GlyLeu: 6.697 ± 0.064	1.383GlyMet: 1.383 ± 0.026	3.174GlyAsn: 3.174 ± 0.082	1.176GlyPro: 1.176 ± 0.028	2.832GlyGln: 2.832 ± 0.042	3.15GlyArg: 3.15 ± 0.048	4.063GlySer: 4.063 ± 0.062	3.757GlyThr: 3.757 ± 0.066	4.659GlyVal: 4.659 ± 0.056	1.068GlyTrp: 1.068 ± 0.025	2.272GlyTyr: 2.272 ± 0.032	0.0GlyXaa: 0.0 ± 0.0
His	1.003HisAla: 1.003 ± 0.023	0.243HisCys: 0.243 ± 0.012	0.728HisAsp: 0.728 ± 0.02	0.898HisGlu: 0.898 ± 0.024	0.807HisPhe: 0.807 ± 0.022	1.07HisGly: 1.07 ± 0.024	0.579HisHis: 0.579 ± 0.023	1.139HisIle: 1.139 ± 0.026	0.786HisLys: 0.786 ± 0.022	2.294HisLeu: 2.294 ± 0.035	0.211HisMet: 0.211 ± 0.012	0.756HisAsn: 0.756 ± 0.021	1.327HisPro: 1.327 ± 0.026	1.175HisGln: 1.175 ± 0.03	1.061HisArg: 1.061 ± 0.023	1.228HisSer: 1.228 ± 0.027	0.88HisThr: 0.88 ± 0.024	0.764HisVal: 0.764 ± 0.018	0.352HisTrp: 0.352 ± 0.014	0.665HisTyr: 0.665 ± 0.019	0.0HisXaa: 0.0 ± 0.0
Ile	6.926IleAla: 6.926 ± 0.064	0.784IleCys: 0.784 ± 0.021	3.696IleAsp: 3.696 ± 0.049	4.3IleGlu: 4.3 ± 0.061	2.693IlePhe: 2.693 ± 0.044	4.339IleGly: 4.339 ± 0.047	1.259IleHis: 1.259 ± 0.029	3.997IleIle: 3.997 ± 0.054	3.421IleLys: 3.421 ± 0.045	6.818IleLeu: 6.818 ± 0.066	0.88IleMet: 0.88 ± 0.024	3.35IleAsn: 3.35 ± 0.047	3.603IlePro: 3.603 ± 0.043	3.252IleGln: 3.252 ± 0.043	3.055IleArg: 3.055 ± 0.038	4.715IleSer: 4.715 ± 0.058	3.964IleThr: 3.964 ± 0.064	4.174IleVal: 4.174 ± 0.057	0.921IleTrp: 0.921 ± 0.024	2.081IleTyr: 2.081 ± 0.034	0.0IleXaa: 0.0 ± 0.0
Lys	4.136LysAla: 4.136 ± 0.061	0.356LysCys: 0.356 ± 0.014	2.279LysAsp: 2.279 ± 0.042	2.933LysGlu: 2.933 ± 0.046	1.959LysPhe: 1.959 ± 0.033	2.756LysGly: 2.756 ± 0.038	0.858LysHis: 0.858 ± 0.021	3.866LysIle: 3.866 ± 0.055	2.621LysLys: 2.621 ± 0.041	5.877LysLeu: 5.877 ± 0.064	0.98LysMet: 0.98 ± 0.024	2.321LysAsn: 2.321 ± 0.037	2.591LysPro: 2.591 ± 0.041	2.866LysGln: 2.866 ± 0.042	2.438LysArg: 2.438 ± 0.036	3.387LysSer: 3.387 ± 0.043	3.157LysThr: 3.157 ± 0.047	3.254LysVal: 3.254 ± 0.044	0.554LysTrp: 0.554 ± 0.018	1.628LysTyr: 1.628 ± 0.034	0.0LysXaa: 0.0 ± 0.0
Leu	9.754LeuAla: 9.754 ± 0.08	1.024LeuCys: 1.024 ± 0.027	5.298LeuAsp: 5.298 ± 0.056	7.317LeuGlu: 7.317 ± 0.072	3.799LeuPhe: 3.799 ± 0.054	7.647LeuGly: 7.647 ± 0.074	1.892LeuHis: 1.892 ± 0.032	6.955LeuIle: 6.955 ± 0.063	5.726LeuLys: 5.726 ± 0.066	11.595LeuLeu: 11.595 ± 0.104	2.006LeuMet: 2.006 ± 0.032	4.786LeuAsn: 4.786 ± 0.054	5.776LeuPro: 5.776 ± 0.064	5.994LeuGln: 5.994 ± 0.057	5.526LeuArg: 5.526 ± 0.055	7.581LeuSer: 7.581 ± 0.07	6.569LeuThr: 6.569 ± 0.089	7.253LeuVal: 7.253 ± 0.067	1.463LeuTrp: 1.463 ± 0.034	2.75LeuTyr: 2.75 ± 0.042	0.0LeuXaa: 0.0 ± 0.0
Met	1.582MetAla: 1.582 ± 0.029	0.114MetCys: 0.114 ± 0.008	0.676MetAsp: 0.676 ± 0.018	0.965MetGlu: 0.965 ± 0.025	0.545MetPhe: 0.545 ± 0.017	1.251MetGly: 1.251 ± 0.028	0.291MetHis: 0.291 ± 0.013	1.09MetIle: 1.09 ± 0.025	0.973MetLys: 0.973 ± 0.022	1.952MetLeu: 1.952 ± 0.036	0.408MetMet: 0.408 ± 0.016	0.857MetAsn: 0.857 ± 0.02	0.915MetPro: 0.915 ± 0.021	0.906MetGln: 0.906 ± 0.024	0.899MetArg: 0.899 ± 0.023	1.273MetSer: 1.273 ± 0.023	1.213MetThr: 1.213 ± 0.028	1.189MetVal: 1.189 ± 0.022	0.162MetTrp: 0.162 ± 0.009	0.362MetTyr: 0.362 ± 0.015	0.0MetXaa: 0.0 ± 0.0
Asn	3.07AsnAla: 3.07 ± 0.052	0.513AsnCys: 0.513 ± 0.018	1.715AsnAsp: 1.715 ± 0.038	1.967AsnGlu: 1.967 ± 0.035	2.085AsnPhe: 2.085 ± 0.034	2.705AsnGly: 2.705 ± 0.062	0.918AsnHis: 0.918 ± 0.023	3.032AsnIle: 3.032 ± 0.056	1.95AsnLys: 1.95 ± 0.035	5.888AsnLeu: 5.888 ± 0.079	0.625AsnMet: 0.625 ± 0.015	2.262AsnAsn: 2.262 ± 0.056	2.943AsnPro: 2.943 ± 0.039	2.87AsnGln: 2.87 ± 0.043	2.412AsnArg: 2.412 ± 0.036	3.401AsnSer: 3.401 ± 0.063	2.416AsnThr: 2.416 ± 0.052	2.249AsnVal: 2.249 ± 0.037	0.788AsnTrp: 0.788 ± 0.02	1.626AsnTyr: 1.626 ± 0.034	0.0AsnXaa: 0.0 ± 0.0
Pro	3.262ProAla: 3.262 ± 0.05	0.328ProCys: 0.328 ± 0.013	2.989ProAsp: 2.989 ± 0.041	3.964ProGlu: 3.964 ± 0.05	1.695ProPhe: 1.695 ± 0.031	3.056ProGly: 3.056 ± 0.042	0.861ProHis: 0.861 ± 0.023	3.0ProIle: 3.0 ± 0.043	2.324ProLys: 2.324 ± 0.042	4.681ProLeu: 4.681 ± 0.053	0.751ProMet: 0.751 ± 0.021	2.256ProAsn: 2.256 ± 0.039	2.318ProPro: 2.318 ± 0.042	2.663ProGln: 2.663 ± 0.037	1.75ProArg: 1.75 ± 0.03	2.945ProSer: 2.945 ± 0.053	2.967ProThr: 2.967 ± 0.048	3.24ProVal: 3.24 ± 0.045	0.599ProTrp: 0.599 ± 0.021	1.288ProTyr: 1.288 ± 0.026	0.0ProXaa: 0.0 ± 0.0
Gln	4.801GlnAla: 4.801 ± 0.06	0.349GlnCys: 0.349 ± 0.014	2.193GlnAsp: 2.193 ± 0.034	3.726GlnGlu: 3.726 ± 0.046	1.758GlnPhe: 1.758 ± 0.032	3.209GlnGly: 3.209 ± 0.043	0.912GlnHis: 0.912 ± 0.023	3.853GlnIle: 3.853 ± 0.045	2.975GlnLys: 2.975 ± 0.042	6.12GlnLeu: 6.12 ± 0.058	1.081GlnMet: 1.081 ± 0.024	2.287GlnAsn: 2.287 ± 0.038	2.79GlnPro: 2.79 ± 0.047	4.059GlnGln: 4.059 ± 0.06	3.035GlnArg: 3.035 ± 0.044	3.003GlnSer: 3.003 ± 0.041	2.985GlnThr: 2.985 ± 0.046	3.862GlnVal: 3.862 ± 0.05	0.62GlnTrp: 0.62 ± 0.02	1.292GlnTyr: 1.292 ± 0.026	0.0GlnXaa: 0.0 ± 0.0
Arg	3.045ArgAla: 3.045 ± 0.041	0.525ArgCys: 0.525 ± 0.018	2.479ArgAsp: 2.479 ± 0.046	3.3ArgGlu: 3.3 ± 0.044	2.119ArgPhe: 2.119 ± 0.038	2.823ArgGly: 2.823 ± 0.048	1.019ArgHis: 1.019 ± 0.023	3.169ArgIle: 3.169 ± 0.044	2.233ArgLys: 2.233 ± 0.035	6.017ArgLeu: 6.017 ± 0.061	0.937ArgMet: 0.937 ± 0.02	2.068ArgAsn: 2.068 ± 0.034	1.989ArgPro: 1.989 ± 0.037	3.317ArgGln: 3.317 ± 0.045	2.929ArgArg: 2.929 ± 0.041	3.081ArgSer: 3.081 ± 0.043	2.456ArgThr: 2.456 ± 0.037	3.233ArgVal: 3.233 ± 0.043	0.804ArgTrp: 0.804 ± 0.022	1.883ArgTyr: 1.883 ± 0.027	0.0ArgXaa: 0.0 ± 0.0
Ser	4.606SerAla: 4.606 ± 0.056	0.597SerCys: 0.597 ± 0.021	3.187SerAsp: 3.187 ± 0.043	3.884SerGlu: 3.884 ± 0.039	2.626SerPhe: 2.626 ± 0.043	4.687SerGly: 4.687 ± 0.062	1.238SerHis: 1.238 ± 0.028	3.87SerIle: 3.87 ± 0.044	2.814SerLys: 2.814 ± 0.038	7.666SerLeu: 7.666 ± 0.069	1.158SerMet: 1.158 ± 0.025	2.909SerAsn: 2.909 ± 0.053	3.562SerPro: 3.562 ± 0.057	3.925SerGln: 3.925 ± 0.046	3.237SerArg: 3.237 ± 0.041	4.579SerSer: 4.579 ± 0.062	3.529SerThr: 3.529 ± 0.05	4.047SerVal: 4.047 ± 0.05	0.948SerTrp: 0.948 ± 0.025	1.873SerTyr: 1.873 ± 0.032	0.0SerXaa: 0.0 ± 0.0
Thr	4.977ThrAla: 4.977 ± 0.064	0.478ThrCys: 0.478 ± 0.014	2.695ThrAsp: 2.695 ± 0.044	3.373ThrGlu: 3.373 ± 0.046	2.174ThrPhe: 2.174 ± 0.042	4.204ThrGly: 4.204 ± 0.081	1.016ThrHis: 1.016 ± 0.024	3.689ThrIle: 3.689 ± 0.054	2.551ThrLys: 2.551 ± 0.039	6.288ThrLeu: 6.288 ± 0.074	0.734ThrMet: 0.734 ± 0.021	2.485ThrAsn: 2.485 ± 0.048	3.476ThrPro: 3.476 ± 0.05	2.943ThrGln: 2.943 ± 0.04	2.344ThrArg: 2.344 ± 0.036	3.503ThrSer: 3.503 ± 0.046	3.474ThrThr: 3.474 ± 0.063	3.99ThrVal: 3.99 ± 0.047	0.702ThrTrp: 0.702 ± 0.018	1.594ThrTyr: 1.594 ± 0.028	0.0ThrXaa: 0.0 ± 0.0
Val	5.528ValAla: 5.528 ± 0.057	0.672ValCys: 0.672 ± 0.017	3.265ValAsp: 3.265 ± 0.043	4.432ValGlu: 4.432 ± 0.057	2.533ValPhe: 2.533 ± 0.038	4.377ValGly: 4.377 ± 0.057	0.979ValHis: 0.979 ± 0.023	4.478ValIle: 4.478 ± 0.061	3.515ValLys: 3.515 ± 0.046	6.538ValLeu: 6.538 ± 0.064	1.325ValMet: 1.325 ± 0.026	3.09ValAsn: 3.09 ± 0.047	2.806ValPro: 2.806 ± 0.038	2.92ValGln: 2.92 ± 0.046	3.154ValArg: 3.154 ± 0.049	4.225ValSer: 4.225 ± 0.052	3.829ValThr: 3.829 ± 0.054	4.72ValVal: 4.72 ± 0.053	0.839ValTrp: 0.839 ± 0.025	1.805ValTyr: 1.805 ± 0.032	0.0ValXaa: 0.0 ± 0.0
Trp	0.855TrpAla: 0.855 ± 0.023	0.162TrpCys: 0.162 ± 0.009	0.651TrpAsp: 0.651 ± 0.025	0.912TrpGlu: 0.912 ± 0.023	0.597TrpPhe: 0.597 ± 0.021	0.945TrpGly: 0.945 ± 0.025	0.349TrpHis: 0.349 ± 0.014	0.823TrpIle: 0.823 ± 0.023	0.627TrpLys: 0.627 ± 0.017	1.912TrpLeu: 1.912 ± 0.039	0.305TrpMet: 0.305 ± 0.014	0.645TrpAsn: 0.645 ± 0.017	0.276TrpPro: 0.276 ± 0.013	1.193TrpGln: 1.193 ± 0.025	0.835TrpArg: 0.835 ± 0.018	0.827TrpSer: 0.827 ± 0.025	0.595TrpThr: 0.595 ± 0.018	0.978TrpVal: 0.978 ± 0.022	0.223TrpTrp: 0.223 ± 0.011	0.461TrpTyr: 0.461 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.093TyrAla: 2.093 ± 0.035	0.399TyrCys: 0.399 ± 0.016	1.409TyrAsp: 1.409 ± 0.029	1.741TyrGlu: 1.741 ± 0.026	1.322TyrPhe: 1.322 ± 0.025	1.981TyrGly: 1.981 ± 0.035	0.692TyrHis: 0.692 ± 0.022	1.891TyrIle: 1.891 ± 0.034	1.364TyrLys: 1.364 ± 0.031	3.725TyrLeu: 3.725 ± 0.053	0.426TyrMet: 0.426 ± 0.015	1.263TyrAsn: 1.263 ± 0.03	1.68TyrPro: 1.68 ± 0.035	2.119TyrGln: 2.119 ± 0.036	1.894TyrArg: 1.894 ± 0.035	2.006TyrSer: 2.006 ± 0.036	1.47TyrThr: 1.47 ± 0.027	1.564TyrVal: 1.564 ± 0.032	0.536TyrTrp: 0.536 ± 0.019	1.085TyrTyr: 1.085 ± 0.029	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 6200 proteins (2006691 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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